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miro.obo
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miro.obo
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format-version: 1.2
data-version: releases/2014-05-14
date: 11:04:2014 11:14
saved-by: Topito
auto-generated-by: OBO-Edit 2.3
default-namespace: mosquito_insecticide_resistance_ontology
treat-xrefs-as-equivalent: CHEBI
treat-xrefs-as-equivalent: CL
treat-xrefs-as-equivalent: EFO
treat-xrefs-as-equivalent: ENVO
treat-xrefs-as-equivalent: GO
treat-xrefs-as-equivalent: IDO
treat-xrefs-as-equivalent: MIRO
treat-xrefs-as-equivalent: OBI
treat-xrefs-as-equivalent: PATO
treat-xrefs-as-equivalent: snap
treat-xrefs-as-equivalent: span
remark: Author: IR curation team
remark: Comments can be sent to
remark: louis[at]imbb.forth.gr
remark: temp version release candidate.
remark: This is an alpha version and is only for experimental implementation.
remark: This is an initial release version
remark: topalis[at]imbb.forth.gr or
remark: Version $Revision: temp$
ontology: miro
owl-axioms: Prefix(owl:=<http://www.w3.org/2002/07/owl#>)\nPrefix(rdf:=<http://www.w3.org/1999/02/22-rdf-syntax-ns#>)\nPrefix(xml:=<http://www.w3.org/XML/1998/namespace>)\nPrefix(xsd:=<http://www.w3.org/2001/XMLSchema#>)\nPrefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)\n\n\nOntology(\nAnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/OBO_REL_influences> \"OBO_REL:influences\"^^xsd:string)\nAnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/OBO_REL_realizes> \"OBO_REL:realizes\"^^xsd:string)\n)
[Term]
id: EFO:0004426
name: karyotype
def: "A karyotype is the number and appearance of chromosomes in the nucleus of a eukaryotic cell." [EFO:0004426]
is_a: snap:Quality ! quality
created_by: Topito
creation_date: 2014-04-10T21:29:44Z
[Term]
id: GO:0000228
name: nuclear chromosome
def: "A chromosome found in the nucleus of a eukaryotic cell." [GO:0000228]
is_a: GO:0005694 ! chromosome
created_by: Topito
creation_date: 2014-04-10T20:48:25Z
[Term]
id: GO:0005575
name: cellular_component
def: "The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GO:0005575]
is_a: snap:MaterialEntity ! material_entity
created_by: Topito
creation_date: 2014-04-10T20:41:11Z
[Term]
id: GO:0005694
name: chromosome
def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [GO:0005694]
is_a: GO:0043226 ! organelle
created_by: Topito
creation_date: 2014-04-10T20:47:16Z
[Term]
id: GO:0043226
name: organelle
def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GO:0043226]
is_a: GO:0005575 ! cellular_component
created_by: Topito
creation_date: 2014-04-10T20:44:51Z
[Term]
id: MIRO:00000000
name: resistance
def: "A heritable change in the sensitivity of a pest population that is reflected in the repeated failure of a product to achieve the expected level of control when used according to the label recommendation for that pest species." [IRAC:manual]
is_a: snap:Disposition ! disposition
[Term]
id: MIRO:00000001
name: Rdl A296S
def: "Resistance-associated point mutation of amino acid at position 296 in the insecticide target GABA receptor gene product causing a structural change and decreased response to the insecticide." [KL:KL]
is_a: MIRO:00000115 ! modified GABA receptor
[Term]
id: MIRO:00000002
name: deficiency of midgut receptor
def: "Loss of function of specific midgut receptors." [PT:PT]
is_a: snap:Quality ! quality
relationship: http://purl.obolibrary.org/obo/OBO_REL_influences MIRO:00000129 ! midgut receptor mediated resistance
[Term]
id: MIRO:00000003
name: metabolic resistance
def: "Class of insecticide resistance that relies on the biochemical transformation of the insecticide, ultimately reducing its capacity to interact with a target molecule." [PMID:16925478]
synonym: "Detoxification" RELATED []
is_a: MIRO:00000021 ! resistance to single insecticide
[Term]
id: MIRO:00000004
name: target-site resistance
def: "Resistance caused by a structural change of the insecticide target gene product leading to decreased response to the insecticide." [KL:KL]
is_a: MIRO:00000021 ! resistance to single insecticide
[Term]
id: MIRO:00000005
name: behavioural resistance
def: "Resistance due to a modification in insect behaviour that helps it avoid the lethal effect of insecticides." [KL:KL]
is_a: MIRO:00000021 ! resistance to single insecticide
[Term]
id: MIRO:00000006
name: reduced cuticle penetration
def: "Modification(s) in the insect cuticle preventing or slowing the absorption or penetration of insecticide." [IRAC:manual]
xref: IRAC:manual "IRAC manual"
is_a: span:Process ! process
relationship: http://purl.obolibrary.org/obo/OBO_REL_realizes MIRO:00000077 ! cuticle permeability related resistance
[Term]
id: MIRO:00000007
name: stimulus dependent resistance
def: "Resistance due to a chemical-dependent modification in insect behaviour that helps it avoid the lethal effect of insecticides (e.G. repellance)." [KL:KL]
is_a: MIRO:00000005 ! behavioural resistance
[Term]
id: MIRO:00000008
name: Kdr V1016G
def: "Resistance-associated point mutation of amino acid at position 1016 (V-G) in the insecticide target sodium channel gene product causing a structural change and decreased response to the insecticide." [KL:KL]
is_a: MIRO:10000225 ! voltage gated sodium channel
relationship: OBO_REL:has_quality MIRO:00000113 ! sodium channel structural change
[Term]
id: MIRO:00000009
name: Kdr V1016I
def: "Resistance-associated point mutation of amino acid at position 1016 (V-I) in the insecticide target sodium channel gene product causing a structural change and decreased response to the insecticide." [KL:KL]
is_a: MIRO:10000225 ! voltage gated sodium channel
relationship: OBO_REL:has_quality MIRO:00000113 ! sodium channel structural change
[Term]
id: MIRO:00000010
name: Kdr I1011M
def: "Resistance-associated point mutation of amino acid at position 1011 (I-M) in the insecticide target sodium channel gene product causing a structural change and decreased response to the insecticide." [KL:KL]
is_a: MIRO:10000225 ! voltage gated sodium channel
relationship: OBO_REL:has_quality MIRO:00000113 ! sodium channel structural change
[Term]
id: MIRO:00000011
name: Kdr I1011V
def: "Resistance-associated point mutation of amino acid at position 1011 (I-V) in the insecticide target sodium channel gene product causing a structural change and decreased response to the insecticide." [KL:KL]
is_a: MIRO:10000225 ! voltage gated sodium channel
relationship: OBO_REL:has_quality MIRO:00000113 ! sodium channel structural change
[Term]
id: MIRO:00000012
name: carboxylesterase resistance
def: "Metabolic resistance due to qualitative or quantitative changes in COE gene products (group of hydrolase enzymes capable of hydrolyzing compounds containing ester bonds) resulting in more efficient insecticide sequestration or metabolism." [IRAC:manual, PMID:16925478]
synonym: "COE resistance" EXACT []
xref: PMID:16925478 "Li et al. (2007), Ann Rev Entomol, 52: 231"
is_a: MIRO:00000003 ! metabolic resistance
[Term]
id: MIRO:00000013
name: COE quantitative change
def: "A change of the COE activity; the resulting metabolic resistance is due to up-regulated COE gene products, which more efficiently sequester or metabolize insecticides." [KL:KL]
synonym: "COE upregulation" EXACT []
is_a: snap:Quality ! quality
relationship: http://purl.obolibrary.org/obo/OBO_REL_influences MIRO:00000012 ! carboxylesterase resistance
[Term]
id: MIRO:00000014
name: Glutathione S-transferase resistance
def: "Metabolic resistance due to quantitative or qualitative changes in GST gene products (phase II metabolic enzymes capable of conjugating reduced glutathione to the electrophilic centers of exogenous and endogenous compounds) resulting in more efficient insecticide detoxification." [PMID:16925478]
synonym: "GSH S-transferase resistance" EXACT []
synonym: "GST resistance" EXACT []
is_a: MIRO:00000003 ! metabolic resistance
[Term]
id: MIRO:00000015
name: P450 monoxygenases resistance
def: "Metabolic resistance due to quantitative or qualitative changes in P450 gene products (phase I metabolic enzymes capable of oxidizing endogenous and exogenous compounds by oxidation or other related reactions) resulting in more efficient insecticide detoxification, or reduced insecticide activation." [PMID:16925478]
synonym: "P450 resistance" RELATED []
xref: PMID:16925478 "Li et al. (2007), Ann Rev Entomol, 52: 231"
is_a: MIRO:00000003 ! metabolic resistance
[Term]
id: MIRO:00000016
name: COE structural change
def: "A change of the COE activity; the resulting metabolic resistance is due to structural change of COE gene product resulting in more efficient metabolism or sequestration of insecticides." [KL:KL]
synonym: "COE mutation" EXACT []
is_a: snap:Quality ! quality
relationship: http://purl.obolibrary.org/obo/OBO_REL_influences MIRO:00000012 ! carboxylesterase resistance
[Term]
id: MIRO:00000017
name: Anopheles gambiae sensu lato karyotype
def: "The karyotype of the members of the Anopheles gambiae species complex." [PT:PT]
is_a: EFO:0004426 ! karyotype
created_by: Topito
creation_date: 2014-04-10T21:34:42Z
[Term]
id: MIRO:00000018
name: jcu/jcu
def: "A karyotype having an homozygous j, c and u 2R chromosome." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000019
name: jbcu/jcu
def: "A karyotype having a j, b, c and u inverted 2R chromosome over a j, c, and u inverted 2R chromosome." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000020
name: jbcu/jbcu
def: "A karyotype having an homozygous j, b, c and u inverted 2R chromosome." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000021
name: resistance to single insecticide
def: "A selected heritable characteristic in an insect population that results in the repeated failure of one single insecticide (but not others within or outside that class) to provide the intended level of control when used as recommended." [IRAC:manual]
is_a: MIRO:00000000 ! resistance
[Term]
id: MIRO:00000022
name: bcu/bcu
def: "A karyotype having an homozygous b, c and u inverted 2R chromosome." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000023
name: cu/bcu
def: "A karyotype having a c and u inverted 2R chromosome over a b, c, and u inverted 2R chromosome." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000024
name: cu/cu
def: "A karyotype having an homozygous c and u inverted 2R chromosome." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000025
name: b/bcu
def: "A karyotype having a b inverted 2R chromosome over a b, c, and u inverted 2R chromosome." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000026
name: b/cu
def: "A karyotype having a b inverted 2R chromosome over a c, and u inverted 2R chromosome." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000027
name: b/b
def: "A karyotype having an homozygous b inverted 2R chromosome." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000028
name: stimulus independent resistance
def: "Resistance resulting from a chemical-independent modification in behaviour that helps the insect avoid the lethal effect of insecticides." [IRAC:manual]
xref: IRAC:manual "IRAC manual"
is_a: MIRO:00000005 ! behavioural resistance
[Term]
id: MIRO:00000029
name: +/bcu
def: "A karyotype having a b,c and u inverted 2R chromosome over wild type." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000030
name: +/cu
def: "A karyotype having a c and u inverted 2R chromosome over wild type." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000031
name: +/b
def: "A karyotype having a b inverted 2R chromosome over wild type." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000032
name: +/+
def: "A karyotype having an homozygous wild type 2R chromosome." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000033
name: u/+
def: "A karyotype having a u inverted 2R chromosome over wild type." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000034
name: u/u
def: "A karyotype having an homozygous u inverted 2R chromosome." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000035
name: bc/+
def: "A karyotype having a b and c inverted 2R chromosome over wild type." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000036
name: bc/u
def: "A karyotype having a b and c inverted 2R chromosome over a u inverted 2R chromosome." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000037
name: bc/bc
def: "A karyotype having an homozygous b and c inverted 2R chromosome." [PT:PT]
is_a: MIRO:00000038 ! Anopheles gambiae sensu lato 2R kayotype
created_by: Topito
creation_date: 2014-04-10T21:39:38Z
[Term]
id: MIRO:00000038
name: Anopheles gambiae sensu lato 2R kayotype
def: "The karyotype of the members of the Anopheles gambiae species complex focusing on the right arm of the second chromosome." [PT:PT]
is_a: MIRO:00000017 ! Anopheles gambiae sensu lato karyotype
created_by: Topito
creation_date: 2014-04-10T21:40:56Z
[Term]
id: MIRO:00000077
name: cuticle permeability related resistance
def: "Change of permeability of the cuticle resulting in reduced insecticide uptake. This can lead to resistance due to lower amounts of insecticide inside the insect's body." [KL:KL]
is_a: MIRO:00000021 ! resistance to single insecticide
[Term]
id: MIRO:00000078
name: enhanced excretion
def: "Increased cuticle or cell-mediated insecticide excretion. This can lead to resistance due to lower amounts of insecticide inside the insect's body." [KL:KL]
is_a: span:Process ! process
relationship: http://purl.obolibrary.org/obo/OBO_REL_realizes MIRO:00000077 ! cuticle permeability related resistance
[Term]
id: MIRO:00000079
name: COEa structural change of gene product in family
def: "Structural change of COEa family gene product due to a mutation of the gene resulting in more efficient insecticide sequestration or metabolism." [KL:KL]
is_a: MIRO:00000016 ! COE structural change
[Term]
id: MIRO:00000080
name: COEb structural change of gene product in family
def: "Structural change of gene product in family COEb family gene product due to a mutation of the gene resulting in more efficient insecticide sequestration or metabolism." [KL:KL]
is_a: MIRO:00000016 ! COE structural change
[Term]
id: MIRO:00000081
name: COEjh structural change of gene product in family
def: "Structural change of gene product in family COEjh family gene product due to a mutation of the gene resulting in more efficient insecticide sequestration or metabolism." [KL:KL]
is_a: MIRO:00000016 ! COE structural change
[Term]
id: MIRO:00000082
name: elevated COEa levels
def: "Increased enzymatic activity due to a mutation that increases production of COEa gene products resulting in more efficient insecticide sequestration or metabolism." [KL:KL]
is_a: MIRO:00000013 ! COE quantitative change
[Term]
id: MIRO:00000083
name: elevated COEb levels
def: "Increased enzymatic activity due to a mutation that increases production of COEb gene products resulting in more efficient insecticide sequestration or metabolism." [KL:KL]
is_a: MIRO:00000013 ! COE quantitative change
[Term]
id: MIRO:00000084
name: elevated COEjh level
def: "Increased enzymatic activity due to a mutation that increases production of COEjh gene products resulting in more efficient insecticide sequestration or metabolism." [KL:KL]
is_a: MIRO:00000013 ! COE quantitative change
[Term]
id: MIRO:00000085
name: GST quantitative change
def: "Increased enzymatic activity due to a mutation that increases production of GST gene products resulting in more efficient insecticide detoxification." [KL:KL]
synonym: "GSH S-transferase upregulation" EXACT []
is_a: snap:Quality ! quality
relationship: http://purl.obolibrary.org/obo/OBO_REL_influences MIRO:00000014 ! Glutathione S-transferase resistance
[Term]
id: MIRO:00000086
name: GST structural change
def: "Structural changes in GST gene products resulting in more efficient insecticide detoxification." [KL:KL]
synonym: "GSH S-tranferase mutation" EXACT []
is_a: snap:Quality ! quality
relationship: http://purl.obolibrary.org/obo/OBO_REL_influences MIRO:00000014 ! Glutathione S-transferase resistance
[Term]
id: MIRO:00000087
name: structural change of product in GSTd gene family
def: "Structural changes in GSTd gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000086 ! GST structural change
[Term]
id: MIRO:00000088
name: structural change of product in GSTe gene family
def: "Structural changes in GSTe gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000086 ! GST structural change
[Term]
id: MIRO:00000089
name: structural change of product in GSTo gene family
def: "Structural changes in GSTo gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000086 ! GST structural change
[Term]
id: MIRO:00000090
name: structural change of product in GSTt gene family
def: "Structural changes in GSTt gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000086 ! GST structural change
[Term]
id: MIRO:00000091
name: structural change of product in GSTu gene family
def: "Structural changes in GSTu gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000086 ! GST structural change
[Term]
id: MIRO:00000092
name: structural change of product in GSTz gene family
def: "Structural changes in GST gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000086 ! GST structural change
[Term]
id: MIRO:00000093
name: elevated GSTd level
def: "Increased enzymatic activity due to a mutation that increases production of GSTd gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000085 ! GST quantitative change
[Term]
id: MIRO:00000094
name: elevated GSTe level
def: "Increased enzymatic activity due to a mutation that increases production of GSTe gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000085 ! GST quantitative change
[Term]
id: MIRO:00000095
name: elevated GSTo level
def: "Increased enzymatic activity due to a mutation that increases production of GSTo gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000085 ! GST quantitative change
[Term]
id: MIRO:00000096
name: elevated GSTt level
def: "Increased enzymatic activity due to a mutation that increases production of GSTt gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000085 ! GST quantitative change
[Term]
id: MIRO:00000097
name: elevated GSTu level
def: "Increased enzymatic activity due to a mutation that increases production of GSTu gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000085 ! GST quantitative change
[Term]
id: MIRO:00000098
name: elevated GSTz level
def: "Increased enzymatic activity due to a mutation that increases production of GSTz gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000085 ! GST quantitative change
[Term]
id: MIRO:00000099
name: P450 structural change
def: "Structural changes in P450 gene products resulting in more efficient insecticide sequestration or metabolism." [KL:KL]
synonym: "P450 mutation" EXACT []
is_a: snap:Quality ! quality
relationship: http://purl.obolibrary.org/obo/OBO_REL_influences MIRO:00000015 ! P450 monoxygenases resistance
[Term]
id: MIRO:00000100
name: P450 quantitative change
def: "Changed enzymatic activity due to a mutation that modifies production of P450 gene products resulting in more efficient insecticide detoxification." [KL:KL]
synonym: "P450 upregulation" RELATED []
is_a: snap:Quality ! quality
relationship: http://purl.obolibrary.org/obo/OBO_REL_influences MIRO:00000015 ! P450 monoxygenases resistance
[Term]
id: MIRO:00000101
name: structural change of product in CYP3 gene family
def: "Structural changes in CYP3 P450 gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000099 ! P450 structural change
[Term]
id: MIRO:00000102
name: structural change of product in CYP4 gene family
def: "Structural changes in CYP4 P450 gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000099 ! P450 structural change
[Term]
id: MIRO:00000103
name: structural change of product in CYP6 gene family
def: "Structural changes in CYP6 P450 gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000099 ! P450 structural change
[Term]
id: MIRO:00000104
name: structural change of product in CYP9 gene family
def: "Structural changes in CYP9 P450 gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000099 ! P450 structural change
[Term]
id: MIRO:00000105
name: structural change of product in CYP12 gene family
def: "Structural changes in CYP12 P450 gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000099 ! P450 structural change
[Term]
id: MIRO:00000106
name: structural change of product in CYP15 gene family
def: "Structural changes in CYP15 P450 gene products resulting in more efficient insecticide detoxification." [KL:KL]
is_a: MIRO:00000099 ! P450 structural change
[Term]
id: MIRO:00000107
name: differential CYP12 level
def: "Modified enzymatic activity due to a mutation that modifies production of CYP12 P450 gene products." [KL:KL]
is_a: MIRO:00000100 ! P450 quantitative change
[Term]
id: MIRO:00000108
name: differential CYP15 level
def: "Modified enzymatic activity due to a mutation that modifies production of CYP15 P450 gene products." [KL:KL]
is_a: MIRO:00000100 ! P450 quantitative change
[Term]
id: MIRO:00000109
name: differential CYP3 level
def: "Modified enzymatic activity due to a mutation that modifies production of CYP3 P450 gene products." [KL:KL]
is_a: MIRO:00000100 ! P450 quantitative change
[Term]
id: MIRO:00000110
name: differential CYP4 level
def: "Modified enzymatic activity due to a mutation that modifies production of CYP4 P450 gene products." [KL:KL]
is_a: MIRO:00000100 ! P450 quantitative change
[Term]
id: MIRO:00000111
name: differential CYP6 level
def: "Modified enzymatic activity due to a mutation that modifies production of CYP6 P450 gene products." [KL:KL]
is_a: MIRO:00000100 ! P450 quantitative change
[Term]
id: MIRO:00000112
name: differential CYP9 level
def: "Modified enzymatic activity due to a mutation that modifies production of CYP9 P450 gene products." [KL:KL]
is_a: MIRO:00000100 ! P450 quantitative change
[Term]
id: MIRO:00000113
name: sodium channel structural change
def: "Structural changes of the insecticide target sodium channel gene product, which decreases its response to the insecticide." [KL:KL]
is_a: snap:Quality ! quality
relationship: http://purl.obolibrary.org/obo/OBO_REL_influences MIRO:00000131 ! sodium channel mediated resistance
[Term]
id: MIRO:00000114
name: AChE structural change
def: "Structural changes of the insecticide target acetylcholinesterase gene product, which decreases its response to the insecticide." [KL:KL]
is_a: snap:Quality ! quality
relationship: http://purl.obolibrary.org/obo/OBO_REL_influences MIRO:00000127 ! AChE mediated resistance
[Term]
id: MIRO:00000115
name: modified GABA receptor
def: "Structural changes of the insecticide target GABA receptor gene product, which decreases its response to the insecticide." [KL:KL]
is_a: MIRO:10000220 ! protein
relationship: http://purl.obolibrary.org/obo/OBO_REL_influences MIRO:00000128 ! GABA receptor mediated resistance
[Term]
id: MIRO:00000116
name: midgut receptor structural change
def: "Structurally modified protein in the insects' midgut that is no longer able to bind an insecticide." [KL:KL]
is_a: snap:Quality ! quality
relationship: http://purl.obolibrary.org/obo/OBO_REL_influences MIRO:00000129 ! midgut receptor mediated resistance
[Term]
id: MIRO:00000117
name: nicotinic receptor structural change
def: "Structural change of the insecticide target nAChR gene product resulting in decreased response to the insecticide." [KL:KL]
is_a: snap:Quality ! quality
relationship: http://purl.obolibrary.org/obo/OBO_REL_influences MIRO:00000130 ! nicotinic receptor mediated resistance
[Term]
id: MIRO:00000118
name: modified midgut protease activity
def: "Modified protease activity caused by a mutation, resulting in differential processing of bacterial pro-insecticides and, thus, reduced toxicity." [KL:KL]
is_a: snap:Quality ! quality
relationship: http://purl.obolibrary.org/obo/OBO_REL_influences MIRO:00000003 ! metabolic resistance
[Term]
id: MIRO:00000119
name: elevated AChE levels
def: "Increased enzymatic activity due to a mutation that increases production of AChE gene products." [KL:KL]
is_a: snap:Quality ! quality
relationship: http://purl.obolibrary.org/obo/OBO_REL_influences MIRO:00000127 ! AChE mediated resistance
[Term]
id: MIRO:00000120
name: AChE1 G119S
def: "Resistance-associated point mutation of amino acid at position 119 in the insecticide target acetylcholinesterase 1 gene product; this structural change leads to decreased response to the insecticide." [PMID:15242706]
is_a: MIRO:10000222 ! acetylcholinesterase
relationship: OBO_REL:has_quality MIRO:00000114 ! AChE structural change
[Term]
id: MIRO:00000121
name: AChE1 F331W
def: "Resistance-associated point mutation of amino acid at position 331 in the insecticide target acetylcholinesterase 1 gene product; this structural change leads to decreased response to the insecticide." [PMID:15242706]
is_a: MIRO:10000222 ! acetylcholinesterase
relationship: OBO_REL:has_quality MIRO:00000114 ! AChE structural change
[Term]
id: MIRO:00000122
name: AChE1 F290V
def: "Resistance-associated point mutation of amino acid at position 290 in the insecticide target acetylcholinesterase 1 gene product; this structural change leads to decreased response to the insecticide." [PMID:15242706]
is_a: MIRO:10000222 ! acetylcholinesterase
relationship: OBO_REL:has_quality MIRO:00000114 ! AChE structural change
[Term]
id: MIRO:00000123
name: Rdl A296G
def: "Resistance-associated point mutation of amino acid at position 296 in the insecticide target GABA receptor gene product causing a structural change and decreased response to the insecticide." [PMID:15242706]
is_a: MIRO:00000115 ! modified GABA receptor
[Term]
id: MIRO:00000124
name: modified Cry
def: "Structural change in the insecticide target Cry gene products resulting in decreased response to insecticides." [KL:KL]
is_a: MIRO:10000227 ! crystal protein
relationship: OBO_REL:has_quality MIRO:00000116 ! midgut receptor structural change
[Term]
id: MIRO:00000125
name: Kdr L1014S
def: "Resistance-associated point mutation of amino acid at position 1014 (L-S) in the insecticide target sodium channel gene product causing a structural change and decreased response to the insecticide." [PMID:15242706]
is_a: MIRO:10000225 ! voltage gated sodium channel
relationship: OBO_REL:has_quality MIRO:00000113 ! sodium channel structural change
[Term]
id: MIRO:00000126
name: Kdr L1014F
def: "Resistance-associated point mutation of amino acid at position 1014 (L-S) in the insecticide target sodium channel gene product causing a structural change and decreased response to the insecticide." [PMID:15242706]
is_a: MIRO:10000225 ! voltage gated sodium channel
relationship: OBO_REL:has_quality MIRO:00000113 ! sodium channel structural change
[Term]
id: MIRO:00000127
name: AChE mediated resistance
def: "Resistance due to mutation leading to structural or quantitative changes of the insecticide target acetylcholinesterase gene product." [KL:KL]
is_a: MIRO:00000004 ! target-site resistance
[Term]
id: MIRO:00000128
name: GABA receptor mediated resistance
def: "Resistance due to mutation leading to structural or quantitative changes of the insecticide target GABA receptor gene product." [KL:KL]
is_a: MIRO:00000004 ! target-site resistance
[Term]
id: MIRO:00000129
name: midgut receptor mediated resistance
def: "Target-site resistance due to the fact that the receptors in the insects' midgut that are responsible for binding an insecticide can no longer function properly due to a mutation in the corresponding gene." [KL:KL]
is_a: MIRO:00000004 ! target-site resistance
[Term]
id: MIRO:00000130
name: nicotinic receptor mediated resistance
def: "Resistance due to mutation leading to structural or quantitative changes of the insecticide target nAChR gene product, resulting in decreased response to the insecticide." [KL:KL]
is_a: MIRO:00000004 ! target-site resistance
[Term]
id: MIRO:00000131
name: sodium channel mediated resistance
def: "Resistance due to mutation leading to structural changes of the insecticide target sodium channel gene product." [KL:KL]
is_a: MIRO:00000004 ! target-site resistance
[Term]
id: MIRO:10000000
name: acetylcholine esterase inhibitor
def: "A chemical substance which inhibits acetylcholine esterase." [PT:PT]
xref: CHEBI:38462
xref: IRAC:eClassification "http://www.irac-online.org/eClassification/"
is_a: snap:Role ! role
[Term]
id: MIRO:10000001
name: chitin biosynthesis inhibitor
def: "A chemical substance which inhibits chitin biosynthesis." [PT:PT]
xref: IRAC:eClassification "http://www.irac-online.org/eClassification/"
is_a: snap:Role ! role
[Term]
id: MIRO:10000002
name: carbamate
def: "A chemical substance which is being used as insecticide." [PT:PT]
is_a: MIRO:10000239 ! insecticidal substance
relationship: OBO_REL:has_role MIRO:10000000 ! acetylcholine esterase inhibitor
[Term]
id: MIRO:10000003
name: aldicarb
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:2555
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000004
name: alanycarb
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38463
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000005
name: aminocarb
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:2653
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000006
name: bendiocarb
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:34556
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000007
name: benfuracarb
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:3014
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000008
name: butocarboxim
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38465
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000009
name: butoxycarboxim
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38470
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000010
name: carbaryl
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:3390
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000011
name: carbofuran
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:34611
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000012
name: carbosulfan
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38476
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000013
name: ethiofencarb
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38483
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000014
name: fenobucarb
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:34304
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000015
name: formetanate
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38491
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000016
name: furathiocarb
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38504
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000017
name: isoprocarb
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38505
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000018
name: methiocarb
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38508
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000019
name: methomyl
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:6835
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000020
name: metolcarb
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38537
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000021
name: oxamyl
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38539
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000022
name: pirimicarb
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:8248
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000023
name: propoxur
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:34938
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000024
name: thiodicarb
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38548
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000025
name: thiofanox
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38549
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000026
name: trimethacarb
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38569
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000027
name: XMC
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38571
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000028
name: xylylcarb
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:35048
is_a: MIRO:10000002 ! carbamate
[Term]
id: MIRO:10000029
name: triazamate
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38576
is_a: MIRO:10000239 ! insecticidal substance
relationship: OBO_REL:has_role MIRO:10000000 ! acetylcholine esterase inhibitor
[Term]
id: MIRO:10000030
name: growth inhibitor
def: "A chemical substance which inhibits growth." [PT:PT]
xref: IRAC:eClassification "http://www.irac-online.org/eClassification/"
is_a: snap:Role ! role
[Term]
id: MIRO:10000031
name: organophosphate
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:25708
is_a: MIRO:10000239 ! insecticidal substance
relationship: OBO_REL:has_role MIRO:10000000 ! acetylcholine esterase inhibitor
[Term]
id: MIRO:10000032
name: acephate
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:34520
is_a: MIRO:10000031 ! organophosphate
[Term]
id: MIRO:10000033
name: azamethiphos
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38578
is_a: MIRO:10000031 ! organophosphate
[Term]
id: MIRO:10000034
name: azinphos-ethyl
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38587
is_a: MIRO:10000031 ! organophosphate
[Term]
id: MIRO:10000035
name: azinphos-methyl
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:2953
is_a: MIRO:10000031 ! organophosphate
[Term]
id: MIRO:10000036
name: cadusafos
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38588
is_a: MIRO:10000031 ! organophosphate
[Term]
id: MIRO:10000037
name: chlorethoxyfos
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38590
is_a: MIRO:10000031 ! organophosphate
[Term]
id: MIRO:10000038
name: chlorfenvinphos
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38598
is_a: MIRO:10000031 ! organophosphate
[Term]
id: MIRO:10000039
name: chlormephos
def: "A chemical substance which is being used as insecticide." [PT:PT]
xref: CHEBI:38603
is_a: MIRO:10000031 ! organophosphate
[Term]
id: MIRO:10000040
name: chlorpyrifos
def: "A chemical substance which is being used as insecticide." [PT:PT]