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multicellular_plan.md

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Multicellular clocks

  • what environmental inputs are required to evolve coupled interactions, rather than a colony of autonomous oscillators?

    • evolve under normal light/dark, then with different noise for each cell, with cost function requiring that the cells are on according to the mean dawn/dusk
    • grid of cells with identical networks
    • to start with, for a specific interaction (say A -> B), then for each interaction (A -> B):
      • add an additional parameter that determines whether its origin node (A) effects the 'B' genes in neighbouring networks
    • to start with, use majority rule as is coded currently (i.e. more activation than repression => activation and vice versa), then if too simple, can set threshold for how much external/internal A is necessary for switching B on/off,
    • then boolean decision for B according to inputs
  • can we evolve quorum sensing - evolving the ability to sense when you have many neighbours

    • if there are only a few then gene A stays off
    • if there are many then gene A turns on