diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
new file mode 100644
index 0000000000..3c4e779ca9
--- /dev/null
+++ b/.github/workflows/ci.yml
@@ -0,0 +1,96 @@
+name: TileDB Python CI
+
+on: [push, pull_request, workflow_dispatch]
+
+concurrency:
+  group: ${{ github.head_ref || github.run_id }}
+  cancel-in-progress: true
+
+jobs:
+  build:
+    runs-on: ${{ matrix.os }}
+    defaults:
+      run:
+        shell: bash
+    strategy:
+      matrix:
+        os: [ubuntu-latest, macos-12, windows-latest]
+        python-version: ["3.8", "3.9", "3.10", "3.11", "3.12"]
+      fail-fast: false
+    env:
+      # 11.7 necessary due to: https://github.com/actions/setup-python/issues/682#issuecomment-1604261330
+      MACOSX_DEPLOYMENT_TARGET: ${{ matrix.os == 'macos-12' && matrix.python-version == '3.8' && '11.7' || '11' }}
+      #MACOSX_DEPLOYMENT_TARGET: "10.11"
+      # On windows-2019 we are using the Visual Studio generator, which is multi-config and places the build artifacts in a subdirectory
+    steps:
+      - name: Checkout TileDB-Py `dev`
+        uses: actions/checkout@v3
+
+      # By default Visual Studio chooses the earliest installed toolset version
+      # for the main build and vcpkg chooses the latest. Force it to use the
+      # latest (14.39 currently).
+      - name: Setup MSVC toolset (VS 2022)
+        uses: TheMrMilchmann/setup-msvc-dev@v3
+        if: matrix.os == 'windows-latest'
+        with:
+          arch: x64
+          toolset: 14.39
+
+      - name: Install Ninja (VS 2022)
+        uses: seanmiddleditch/gha-setup-ninja@v4
+        if: matrix.os == 'windows-latest'
+
+      - name: Set up Python ${{ matrix.python-version }}
+        uses: actions/setup-python@v4
+        with:
+          python-version: ${{ matrix.python-version }}
+
+      - name: Print Python version
+        run: |
+          which python
+          which pip
+          python --version
+
+      - name: Print env
+        run: printenv
+
+      - name: Print pip debug info
+        run: pip debug --verbose
+
+      # Remove after upstream PR fully-deployed:
+      # - https://github.com/actions/runner-images/pull/7125
+      - name: "Install homebrew dependencies"
+        run: brew install pkg-config
+        if: matrix.os == 'macos-12'
+
+      - name: "Install libfaketime (linux and macOS)"
+        if: matrix.os == 'ubuntu-latest' || matrix.os == 'macos-12'
+        run: |
+          git clone https://github.com/wolfcw/libfaketime/
+          cd libfaketime
+          sudo make install
+          cd ..
+
+      - name: "Build TileDB-Py"
+        run: pip install --verbose .
+
+      - name: "Run tests"
+        run: |
+          PROJECT_CWD=$PWD
+          rm tiledb/__init__.py
+          cd /tmp
+          pytest -vv --showlocals $PROJECT_CWD
+
+      - name: "Print log files (failed build only)"
+        run: |
+          set -xeo pipefail
+          # Display log files if the build failed
+          echo 'Dumping log files for failed build'
+          echo '----------------------------------'
+          for f in $(find build -name *.log);
+            do echo '------'
+               echo $f
+               echo '======'
+               cat $f
+            done;
+        if: failure()