diff --git a/.gitignore b/.gitignore
index 9daa9a8fc3..04b7efebbb 100644
--- a/.gitignore
+++ b/.gitignore
@@ -7,9 +7,6 @@ __pycache__/
 *.so
 *.dylib
 
-# Cython extensions
-*.cpp
-
 # Distribution / packaging
 .Python
 env/
diff --git a/pyproject.toml b/pyproject.toml
index 0e822ea338..9d2d7d124f 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -2,7 +2,6 @@
 requires = [
     "scikit-build-core",
     "pybind11",
-    "Cython>=3",
     "numpy>=2.0.1"
 ]
 build-backend = "scikit_build_core.build"
diff --git a/tiledb/__init__.py b/tiledb/__init__.py
index 93ed6c3dfe..4bffb4e32e 100644
--- a/tiledb/__init__.py
+++ b/tiledb/__init__.py
@@ -2,15 +2,6 @@
 import os
 import sys
 
-# un-comment this section to fix Cython backtrace line-numbers in
-# IPython/Jupyter. see https://bugs.python.org/issue32797#msg323167
-# ---
-# try:
-#    from importlib.machinery import ExtensionFileLoader
-# else:
-#    del ExtensionFileLoader.get_source
-# ---
-
 if os.name == "posix":
     if sys.platform == "darwin":
         lib_name = "libtiledb.dylib"
diff --git a/tiledb/cc/array.cc b/tiledb/cc/array.cc
index f3e3512512..392d1950b1 100644
--- a/tiledb/cc/array.cc
+++ b/tiledb/cc/array.cc
@@ -50,7 +50,6 @@ void init_array(py::module &m) {
                                 end.value()));
            }),
            py::keep_alive<1, 2>())
-      // Temporary initializer while Array is converted from Cython to PyBind.
       .def(py::init([](const Context &ctx, py::object array) {
              tiledb_array_t *c_array = (py::capsule)array.attr("__capsule__")();
              return std::make_unique<Array>(ctx, c_array, false);
diff --git a/tiledb/numpyFlags.h b/tiledb/numpyFlags.h
deleted file mode 100644
index be21064176..0000000000
--- a/tiledb/numpyFlags.h
+++ /dev/null
@@ -1,2 +0,0 @@
-// Turn off cython generated deprecation warnings
-#define NPY_NO_DEPRECATED_API NPY_1_7_API_VERSION
\ No newline at end of file