GPR curation for Transport reactions (13)

[JHL-452b]

Current behavior:

50 genes are discovered to be uncorrelated with their corresponding reactions in Transport reactions.

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000165029	O95477	MAR00235: 7-palmitoleic acid + ATP + H2O --> 7-palmitoleic acid + ADP + H+ + Pi	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000165029 catalyzes the translocation of specific phospholipids and cholesterol across membranes, utilizing ATP hydrolysis. The provided reaction involves 7-palmitoleic acid, which is not mentioned in any of the catalytic activities or functions associated with the gene. Therefore, the gene and the reaction are not related.	No
ENSG00000165029	O95477	MAR00247: 9-heptadecylenic acid + ATP + H2O --> 9-heptadecylenic acid + ADP + H+ + Pi	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The reactions catalyzed by the gene ENSG00000165029 involve the translocation of specific phospholipids, sphingomyelin, and cholesterol across membranes coupled with ATP hydrolysis. In contrast, the reaction provided involves the conversion of 9-heptadecylenic acid using ATP, which is not related to the gene's function of phospholipid and cholesterol transport. Therefore, the gene does not play a role in the given reaction.	No
ENSG00000165029	O95477	MAR00307: ATP + H2O + mead acid --> ADP + H+ + mead acid + Pi	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 encodes a protein that catalyzes the translocation of specific phospholipids and cholesterol in cellular membranes, using ATP hydrolysis as an energy source. The described reactions involve phospholipid and cholesterol transport but do not include any reaction related to "mead acid." The provided reaction (ATP + H2O + mead acid --> ADP + H+ + mead acid + Pi) involving mead acid does not align with the known functions of the gene, which is related to phospholipid and cholesterol translocation. Hence, the gene ENSG00000165029 is not relevant to the described reaction.	No
ENSG00000165029	O95477	MAR00321: ATP + cis-erucic acid + H2O --> ADP + cis-erucic acid + H+ + Pi	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000165029 encodes a protein that catalyzes the translocation of specific phospholipids and cholesterol across membranes, coupled to the hydrolysis of ATP. The annotated reactions primarily involve the movement of phospholipids and cholesterol, which are different from the reaction provided, namely the hydrolysis of ATP and cis-erucic acid. Therefore, the gene's function does not match the given reaction involving ATP and cis-erucic acid.	No
ENSG00000165029	O95477	MAR00339: ATP + H2O + nervonic acid --> ADP + H+ + nervonic acid + Pi	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 encodes a protein that catalyzes the translocation of specific phospholipids and cholesterol across membranes coupled with the hydrolysis of ATP, as evidenced by various publications. However, the reaction involving the hydrolysis of ATP and nervonic acid does not involve translocation of phospholipids or cholesterol, thus making the gene unrelated to the provided reaction.	No
ENSG00000165029	O95477	MAR00347: ATP + H2O + ximenic acid --> ADP + H+ + Pi + ximenic acid	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 encodes a protein that catalyzes the translocation of specific phospholipids, such as phosphatidylcholine, phosphatidylserine, and sphingomyelin, and cholesterol across membranes, and this process is coupled to the hydrolysis of ATP. However, the provided reaction involves the conversion of ATP, H2O, and ximenic acid into ADP, H+, Pi, and ximenic acid. Since ximenic acid is not one of the substrates mentioned in the gene's annotated functions and the reaction does not involve the translocation of phospholipids or cholesterol, the gene is not related to the reaction.	No
ENSG00000165029	O95477	MAR00359: ATP + H2O + omega-3-arachidonic acid --> ADP + H+ + omega-3-arachidonic acid + Pi	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 encodes for a protein that catalyzes the translocation of specific phospholipids and cholesterol across cell membranes, a process coupled with ATP hydrolysis. However, the reaction provided involves the conversion of ATP and omega-3-arachidonic acid into ADP, H+, Pi, and omega-3-arachidonic acid, which does not involve the translocation of phospholipids or cholesterol. Consequently, the annotated catalytic activities and functions of the gene product do not align with the provided reaction, indicating they are not related.	No
ENSG00000165029	O95477	MAR00399: ATP + H2O + linoleate --> ADP + H+ + linoleate + Pi	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000165029 encodes a protein that catalyzes the translocation of specific phospholipids and cholesterol across membranes, coupled with the hydrolysis of ATP, to aid in phospholipid transfer to apolipoproteins and HDL formation. The catalytic activities described for this gene involve the translocation of phosphatidylcholine, phosphatidylserine, sphingomyelin, and cholesterol, none of which involve the reaction ATP + H2O + linoleate --> ADP + H+ + linoleate + Pi. Therefore, the gene's function does not correspond with the provided reaction involving linoleate.	No
ENSG00000021488	P82251	MAR01898: glutathionyl-leukotriene C4 + HCO3- + noradrenaline <=> glutathionyl-leukotriene C4 + HCO3- + noradrenaline	ENSG00000021488 or ENSG00000084453 or ENSG00000111700	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 codes for a protein that associates with SLC3A1 to form a transporter complex involved in the exchange of cationic and neutral amino acids. The catalytic activities described for this gene involve various amino acids, such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the reaction provided, which involves glutathionyl-leukotriene C4, HCO3-, and noradrenaline, does not involve any of these amino acids or relate to the amino acid transporter function of the gene. Therefore, the gene is not related to the reaction provided.	No
ENSG00000021488	P82251	MAR01900: HCO3- + noradrenaline + S-glutathionyl-ethacrynic acid <=> HCO3- + noradrenaline + S-glutathionyl-ethacrynic acid	ENSG00000021488 or ENSG00000084453 or ENSG00000111700	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes for a transporter protein that mediates the exchange of cationic and neutral amino acids across the cell membrane, such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The described reaction involves HCO3-, noradrenaline, and S-glutathionyl-ethacrynic acid, which are not substrates for the transporter encoded by ENSG00000021488. Therefore, there is no connection between the gene's product and the reaction provided based on the annotation.	No
ENSG00000084453	P46721	MAR01905: acetylcholine + HCO3- + S-glutathionyl-2-4-dinitrobenzene <=> acetylcholine + HCO3- + S-glutathionyl-2-4-dinitrobenzene	ENSG00000021488 or ENSG00000084453 or ENSG00000111700	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000084453 encodes a Na(+)-independent transporter involved in the uptake of various organic anions and clinically used drugs. It transports bile acids, steroids, thyroid hormones, prostaglandins, and neuropeptides, but there is no evidence suggesting that it catalyzes the reaction involving acetylcholine, HCO3-, and S-glutathionyl-2-4-dinitrobenzene. Therefore, the gene is not related to the reaction described.	No
ENSG00000091138	P40879	MAR04946: 2.0 HCO3- + sulfate --> 2.0 HCO3- + sulfate	ENSG00000091138 or ENSG00000112053 or ENSG00000145217 or ENSG00000147606 or ENSG00000155850 or ENSG00000174502 or ENSG00000181045	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000091138 mediates a chloride-bicarbonate exchange in intestinal epithelia with a chloride to bicarbonate stoichiometry of 2:1, according to multiple PubMed references. The reaction provided, however, involves bicarbonate (HCO3-) and sulfate without any mention of chloride. Therefore, the gene and the specified reaction are unrelated based on the gene's known function and catalytic activity.	No
ENSG00000163581	P11168	MAR04996: glucosamine --> glucosamine	ENSG00000117394 or ENSG00000163581 or ENSG00000181856	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000163581 encodes a facilitative hexose transporter primarily involved in the transport of glucose, fructose, galactose, and dehydroascorbate across the plasma membrane. The catalytic activities of the gene involve specific reactions related to these substrates' transport but do not include any reactions involving the conversion or transport of glucosamine. Therefore, the gene and the reaction involving glucosamine are not related.	No
ENSG00000139209	Q969I6	MAR05071: lysine --> lysine	ENSG00000003989 or ENSG00000139209 or ENSG00000139514 or ENSG00000165349	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000139209 encodes a symporter responsible for the cotransport of neutral amino acids and sodium ions, such as glycine, L-alanine, L-serine, L-asparagine, L-threonine, L-cysteine, L-histidine, L-proline, L-glutamine, and L-methionine. The provided reaction involves lysine, which is not one of the substrates handled by this gene's symporter function as described.	No
ENSG00000167703	Q8N370	MAR05074: tyrosine <=> tyrosine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000112394 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000167703 encodes a uniporter involved in the transport of specific neutral amino acids such as L-phenylalanine, L-methionine, L-leucine, and L-isoleucine, facilitating their movement across cell membranes. However, the reaction provided involves only tyrosine, which is not listed as a substrate or product associated with the catalytic activities of this gene. Therefore, the gene is not relevant to the reaction involving tyrosine.	No
ENSG00000155465	Q9UM01	MAR05076: glycine --> glycine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000130876 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000164363 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000155465 functions as an antiporter involved in the transport of cationic and neutral amino acids, specifically operating with substances like L-arginine, L-leucine, L-lysine, and L-ornithine. The reactions specified in its functional annotation include exchanges between these amino acids and sodium ions across the cell membrane. However, the reaction provided, which involves glycine transforming into glycine, does not align with the specific transport functions or catalytic activities associated with the gene. Therefore, the gene is not relevant to the glycine --> glycine reaction.	No
ENSG00000149150	O75387	MAR05077: alanine --> alanine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000130876 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149150 encodes a uniporter that specifically mediates the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, L-phenylalanine, and L-methionine, as shown by multiple sources including PubMed:12930836. The gene's catalytic activities are restricted to the transport of these amino acids in and out of cells; it does not specify any activity related to the reaction of alanine. The reaction provided, which involves the conversion of alanine, is not aligned with the gene's annotated functions and catalytic activities.	No
ENSG00000165349	Q8WY07	MAR05085: leucine <=> leucine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165349 mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine, and L-ornithine and facilitates their translocation across the membrane. However, the provided reaction involves leucine, a neutral amino acid, which is not listed among the substrates transported by the protein encoded by this gene. Thus, the gene is not relevant to the leucine-related reaction.	No
ENSG00000139514	P30825	MAR05085: leucine <=> leucine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000139514 encodes a permease involved in the high-affinity transport of cationic amino acids such as arginine, lysine, ornithine, and homoarginine across non-hepatic tissues. The reactions catalyzed by this gene are specifically the transport of these amino acids in and out of cells. However, the reaction mentioned in the query involves the interconversion of leucine, a non-cationic amino acid, which is not within the functional scope of the gene's activity. Therefore, there is no relevance between the gene's function and the leucine reaction.	No
ENSG00000103257	Q01650	MAR05087: proline --> proline	ENSG00000003989 or ENSG00000092068 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103257, in association with SLC3A2, primarily functions as a transporter mediating the uptake and exchange of various large neutral amino acids, L-DOPA, thyroid hormones, and other molecules across cell membranes. However, the reaction involving the conversion of proline to proline does not align with the known functions and catalytic activities associated with this gene, as there is no mention of proline transport or transformation in the provided information.	No
ENSG00000178537	O43772	MAR05328: aspartate + Na+ --> aspartate + Na+	ENSG00000079215 or ENSG00000105143 or ENSG00000106688 or ENSG00000110436 or ENSG00000178537	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000178537 is involved in the exchange of acylcarnitines with free carnitine across the mitochondrial inner membrane, which is central to the mitochondrial fatty acid beta-oxidation pathway. However, the reaction provided involves the transport of aspartate and sodium ions, which does not align with the gene's annotated functions or catalytic activities described.	No
ENSG00000103257	Q01650	MAR05468: asparagine + glycine <=> asparagine + glycine	ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103257 encodes for a transporter that mediates the uptake and exchange of large neutral amino acids such as phenylalanine, tyrosine, leucine, histidine, methionine, tryptophan, valine, isoleucine, alanine, and thyroid hormones across cell membranes. The listed catalytic activities do not include any reaction involving asparagine and glycine. Therefore, the gene is not related to the reaction provided: asparagine + glycine <=> asparagine + glycine.	No
ENSG00000165029	O95477	MAR05533: phenylalanine + tyrosine <=> phenylalanine + tyrosine	ENSG00000103257 or ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 encodes a protein that catalyzes the translocation of specific phospholipids and cholesterol across membranes using ATP hydrolysis. The described reactions involve phosphatidylcholine, phosphatidylserine, sphingomyelin, and cholesterol but do not involve phenylalanine or tyrosine. The provided reaction involves phenylalanine and tyrosine interconversion, which is unrelated to the gene's annotated functions.	No
ENSG00000103064	Q92536	MAR05593: glycine + Na+ + tyrosine --> glycine + Na+ + tyrosine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, specifically involved in the transport of cationic and neutral amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, isoleucine, and others, in exchange with sodium ions or other amino acids. The provided reaction involves the transport of glycine and tyrosine in the presence of sodium ions, which does not match the specific substrate specificity described for the gene product. Therefore, the gene's function is not related to the given reaction involving glycine and tyrosine transport.	No
ENSG00000103257	Q01650	MAR05597: asparagine + glycine + Na+ --> asparagine + glycine + Na+	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103257 is associated with the transport of large neutral amino acids, thyroid hormones, methylmercury, and small molecular weight nitrosothiols. The catalytic activities listed involve the transport or exchange of specific amino acids and hormones across cell membranes. In contrast, the provided reaction involves asparagine, glycine, and sodium, which are not mentioned in the gene's annotated functions or catalytic activities. Therefore, the gene does not appear to be related to this reaction.	No
ENSG00000103064	Q92536	MAR05599: glycine + Na+ + threonine --> glycine + Na+ + threonine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that primarily functions as an antiporter, exchanging cationic amino acids such as L-arginine with neutral amino acids like L-leucine, L-glutamine, and others, often in a sodium-dependent manner. The described reactions are specific for L-arginine exchange with other amino acids or ions. However, the provided reaction involves the exchange of glycine, Na+, and threonine, which does not match any of the catalytic activities associated with the gene ENSG00000103064. Therefore, the gene and the reaction are not related.	No
ENSG00000103064	Q92536	MAR05611: alanine + Na+ + proline --> alanine + Na+ + proline	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter for cationic and neutral amino acids, primarily involving L-arginine, in exchange with other amino acids such as L-lysine, L-leucine, and L-glutamine, often with the involvement of sodium ions. It does not catalyze a reaction involving alanine and proline. Therefore, the gene does not pertain to the provided reaction of alanine, Na+, and proline.	No
ENSG00000103064	Q92536	MAR05612: alanine + asparagine + Na+ --> alanine + asparagine + Na+	ENSG00000103064 or ENSG00000105281	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter, facilitating the exchange of cationic amino acids such as L-arginine with neutral amino acids like L-leucine, L-glutamine, and isoleucine, along with sodium ions. The catalytic activities specified involve various amino acids including L-lysine, L-histidine, L-cysteine, and L-methionine, but none of the reactions described in the gene's function involve alanine or asparagine. Thus, the reaction "alanine + asparagine + Na+ --> alanine + asparagine + Na+" does not align with the transport activities associated with the gene ENSG00000103064.	No
ENSG00000103064	Q92536	MAR05618: alanine + glutamine + Na+ --> alanine + glutamine + Na+	ENSG00000103064 or ENSG00000105281	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, specifically facilitating the exchange of cationic amino acids such as L-arginine with neutral amino acids like L-leucine, L-glutamine, and others, often in a sodium-dependent manner. The provided reaction involves the exchange of alanine, glutamine, and sodium ions, but this does not match any of the catalytic activities described for the gene ENSG00000103064, which does not mention the transport of alanine. Therefore, the gene and the reaction are not related.	No
ENSG00000103257	Q01650	MAR05630: glutamine + homoserine + Na+ --> glutamine + homoserine + Na+	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103257 codes for a transporter protein that mediates the uptake and exchange of various amino acids and thyroid hormones across cell membranes. It is involved in transporting large neutral amino acids like phenylalanine, tyrosine, leucine, histidine, methionine, tryptophan, valine, isoleucine, alanine, and thyroid hormones. However, the reaction provided (glutamine + homoserine + Na+ --> glutamine + homoserine + Na+) does not involve the transport or exchange of any of these molecules and does not align with the activities described for the gene¡¯s associated protein. Therefore, there is no connection between the gene and the given reaction.	No
ENSG00000103064	Q92536	MAR05649: glutamine + methionine + Na+ --> glutamine + methionine + Na+	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions as an antiporter, specifically exchanging cationic amino acids like L-arginine with neutral amino acids such as L-leucine, L-glutamine, L-isoleucine, plus sodium ions. It also facilitates the transport of other amino acids like L-lysine, L-histidine, L-cysteine, and L-methionine in a similar manner. However, the reaction provided involves "glutamine + methionine + Na+ --> glutamine + methionine + Na+", which does not fit the antiporter activity of the gene product. The reaction implies no net transport or exchange of amino acids, which is contrary to the gene's known function in amino acid exchange.	No
ENSG00000103064	Q92536	MAR05651: methionine + Na+ + tryptophan --> methionine + Na+ + tryptophan	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions as an antiporter, specifically exchanging cationic amino acids like L-arginine with neutral amino acids such as L-leucine, L-glutamine, and others, in addition to sodium ions. The catalyzed reactions involve the exchange of L-arginine with various other amino acids and sodium ions, as detailed in multiple studies. However, the given reaction involves methionine and tryptophan with sodium ions, which is not among the reactions annotated for this gene. Thus, there is no direct relevance between the gene's documented function and the provided reaction.	No
ENSG00000103064	Q92536	MAR05654: cysteine + methionine + Na+ --> cysteine + methionine + Na+	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 is involved in transporting amino acids like L-arginine in exchange with other amino acids such as L-leucine, L-glutamine, L-lysine, and sodium ions. The provided reaction involves cysteine and methionine with sodium, which does not align with the gene's annotated transport activities or substrates. Therefore, the reaction is not related to the gene's function.	No
ENSG00000103064	Q92536	MAR05665: Na+ + serine + tryptophan --> Na+ + serine + tryptophan	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 is involved in the catalytic activity related to the exchange of L-arginine with other amino acids such as L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, often in a sodium-dependent manner. The provided reaction involves the exchange of Na+ with serine and tryptophan, which is not listed among the substrates or products associated with the gene's described activities. Hence, this gene does not participate in the reaction provided.	No
ENSG00000103064	Q92536	MAR05671: Na+ + proline + tryptophan --> Na+ + proline + tryptophan	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter for exchanging cationic amino acids like L-arginine with neutral amino acids such as L-leucine and L-glutamine, often involving sodium ions. The catalytic activities described involve exchanges of specific amino acids with L-arginine and sodium ions, which are distinct from the reaction provided. The reaction Na+ + proline + tryptophan --> Na+ + proline + tryptophan does not match the substrate specificity or the antiport mechanism described for the gene's protein product, indicating it is not related to the gene's annotated function.	No
ENSG00000103064	Q92536	MAR05673: Na+ + tryptophan + valine --> Na+ + tryptophan + valine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that catalyzes reactions involving the exchange of L-arginine with other amino acids, such as L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, as well as with sodium ions. However, the provided reaction involves the exchange of tryptophan and valine with sodium ions, which is not a function associated with this gene. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000103064	Q92536	MAR05684: cysteine + Na+ + phenylalanine --> cysteine + Na+ + phenylalanine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064, encoding a transporter protein, primarily facilitates the exchange of L-arginine with various amino acids such as L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, often involving sodium ions. The provided reaction involves the exchange of cysteine, sodium ions, and phenylalanine, which does not align with any of the transport activities documented for this gene. Therefore, the gene does not participate in the reaction cysteine + Na+ + phenylalanine ¡ú cysteine + Na+ + phenylalanine.	No
ENSG00000103064	Q92536	MAR05698: Na+ + phenylalanine + tyrosine --> Na+ + phenylalanine + tyrosine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter for the exchange of cationic and neutral amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, and several others, often with the involvement of sodium ions. The described catalytic activities do not include any reactions involving phenylalanine and tyrosine as specified in the provided reaction. Therefore, based on the gene¡¯s annotated function, it does not participate in the reaction Na+ + phenylalanine + tyrosine --> Na+ + phenylalanine + tyrosine.	No
ENSG00000103064	Q92536	MAR05708: alanine + cysteine + Na+ --> alanine + cysteine + Na+	ENSG00000103064 or ENSG00000105281 or ENSG00000115902	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes for a protein that functions as an antiporter involved in the exchange of cationic amino acids such as L-arginine with neutral amino acids like L-leucine, L-glutamine, and others, along with sodium ions. The catalytic activities mentioned in the annotations involve specific amino acids and conditions, but the provided reaction solely involves alanine, cysteine, and sodium ions with no exchange mechanism or the involvement of L-arginine or other specific substrates mentioned. Therefore, there is no direct relationship between the gene's function and the specified reaction.	No
ENSG00000105281	Q15758	MAR05708: alanine + cysteine + Na+ --> alanine + cysteine + Na+	ENSG00000103064 or ENSG00000105281 or ENSG00000115902	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000105281 encodes a sodium-coupled antiporter of neutral amino acids, mainly facilitating the exchange of L-glutamine with other neutral amino acids like L-serine, L-threonine, and L-asparagine, coupled with sodium ion transport. However, the provided reaction involves the exchange of alanine and cysteine with sodium ions, and no relevant catalytic activity or function associated with the transport of cysteine by this gene is documented in the provided annotation. Therefore, the gene is not relevant to the specific reaction involving alanine and cysteine.	No
ENSG00000103064	Q92536	MAR05710: cysteine + Na+ + serine --> cysteine + Na+ + serine	ENSG00000103064 or ENSG00000105281 or ENSG00000115902	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, exchanging L-arginine with various neutral amino acids and sodium ions (such as L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine) or exchanging L-arginine with L-lysine in a sodium-independent manner. The reaction described, "cysteine + Na+ + serine --> cysteine + Na+ + serine," does not align with the functional capabilities of the gene's product, which involves the exchange of amino acids rather than serine or a unidirectional reaction without the involvement of L-arginine. Therefore, the gene is not linked to the provided reaction.	No
ENSG00000103064	Q92536	MAR05729: leucine + Na+ + tyrosine --> leucine + Na+ + tyrosine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, exchanging various amino acids such as L-arginine, L-lysine, L-leucine, and others, often in the presence of sodium ions. The specific reaction provided, "leucine + Na+ + tyrosine --> leucine + Na+ + tyrosine," does not match any of the described catalytic activities of the protein encoded by ENSG00000103064, which involve exchanges between L-arginine and other amino acids, not involving tyrosine. Therefore, the gene and the reaction are not related.	No
ENSG00000103064	Q92536	MAR05737: glycine + Na+ + proline --> glycine + Na+ + proline	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter for cationic amino acids like L-arginine, exchanging them with neutral amino acids such as L-leucine, L-glutamine, and isoleucine, plus sodium ions. It does not participate in the reaction involving glycine, Na+, and proline. Therefore, based on its annotation, the gene does not relate to the provided reaction.	No
ENSG00000103064	Q92536	MAR05743: Na+ + phenylalanine + proline --> Na+ + phenylalanine + proline	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as a heterodimer with SLC3A2, primarily involved in the antiport of amino acids such as L-arginine in exchange for neutral amino acids like L-leucine, L-glutamine, and others, along with sodium ions. The catalytic activities described indicate exchanges involving L-arginine with other amino acids and sodium ions but do not involve phenylalanine and proline. The provided reaction involves the exchange of Na+ with phenylalanine and proline, which does not align with the annotated functions of the gene product. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000103064	Q92536	MAR05757: asparagine + Na+ + tryptophan --> asparagine + Na+ + tryptophan	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 is associated with the transport of cationic amino acids such as L-arginine and neutral amino acids like L-leucine, L-glutamine, isoleucine, and other specific amino acids, often in exchange with sodium ions. The described reactions involve L-arginine and its exchange with other amino acids. However, the provided reaction involves asparagine, sodium, and tryptophan, which are not substrates or products in the transport processes mediated by the gene's protein product. Therefore, the gene's function does not pertain to the given reaction.	No
ENSG00000103064	Q92536	MAR05759: asparagine + Na+ + tyrosine --> asparagine + Na+ + tyrosine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 is involved in the transport of cationic amino acids, such as L-arginine, in exchange for neutral amino acids like L-leucine, L-glutamine, and isoleucine, and sometimes involves sodium ions. However, the provided reaction involves asparagine, sodium, and tyrosine, which are not mentioned in the gene's known catalytic activities listed in the provided annotation. Therefore, there is no direct evidence to support the involvement of ENSG00000103064 in the reaction asparagine + Na+ + tyrosine --> asparagine + Na+ + tyrosine.	No
ENSG00000103064	Q92536	MAR05762: asparagine + Na+ + proline --> asparagine + Na+ + proline	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 functions as an antiporter, specifically exporting cationic amino acids such as L-arginine in exchange for neutral amino acids like L-leucine, L-glutamine, and isoleucine, plus sodium ions. The reactions it catalyzes involve exchanges between various amino acids and sodium ions, but not asparagine and proline as mentioned in the reaction provided. Therefore, the gene's annotated functions and catalytic activities do not relate to the reaction involving asparagine, sodium, and proline.	No
ENSG00000103064	Q92536	MAR05772: Na+ + tryptophan + valine --> Na+ + tryptophan + valine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions in the exchange of L-arginine with various other amino acids such as L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, often in the presence of sodium ions. However, the reaction given involves the movement of Na+, tryptophan, and valine, which do not align with the annotated catalytic activities of the gene. Hence, the gene's function does not pertain to the specific reaction involving tryptophan and valine.	No
ENSG00000103064	Q92536	MAR05786: methionine + Na+ + threonine --> methionine + Na+ + threonine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions as an antiporter for various cationic and neutral amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, with or without sodium ions, as per multiple cited studies. The provided reaction involves methionine, sodium ions, and threonine, but there is no relevant annotation or evidence indicating that the gene-associated protein facilitates the exchange involving threonine. Thus, the protein's known functions and catalytic activities do not match the reaction provided, establishing that the gene is irrelevant to this specific reaction.	No
ENSG00000103064	Q92536	MAR05802: homoserine + Na+ + tryptophan --> homoserine + Na+ + tryptophan	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter for various amino acids, including L-arginine, L-lysine, L-leucine, and others, often in the presence of sodium ions. The provided reaction involving homoserine, Na+, and tryptophan is not among the listed reactions catalyzed by the protein product of this gene. Therefore, based on the gene's function and catalytic activities, it does not participate in or facilitate the reaction involving homoserine, Na+, and tryptophan.	No

[hhl-24]

all of these seem fine to me.