GPR curation for Transport reactions (12)

[JHL-452b]

Current behavior:

50 genes are discovered to be uncorrelated with their corresponding reactions in Transport reactions.

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000125454	Q9HC21	MAR07835: dTTP + dUDP --> dTTP + dUDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter involved in the uptake of thiamine diphosphate into mitochondria and functions as an antiporter for thiamine diphosphate and thiamine phosphate. The provided reaction, however, involves the conversion of dTTP and dUDP, which is unrelated to the gene's function or catalytic activity involving thiamine derivatives. Thus, the gene and the reaction are not related.	No
ENSG00000125454	Q9HC21	MAR07837: dGDP + dTTP --> dGDP + dTTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The annotated gene ENSG00000125454 encodes for a mitochondrial transporter facilitating the uptake of thiamine diphosphate into mitochondria and shows antiporter activity specifically involving thiamine diphosphate and thiamine phosphate. However, the given reaction (dGDP + dTTP --> dGDP + dTTP) involves nucleotide exchanges between dGDP and dTTP, which are entirely unrelated to thiamine diphosphate transport or antiporter activity of the annotated gene. Therefore, the gene and the reaction are not related.	No
ENSG00000125454	Q9HC21	MAR07838: dADP + dTTP --> dADP + dTTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 is involved in the mitochondrial transport of thiamine diphosphate and shows catalytic activity related to the exchange of thiamine diphosphate and thiamine phosphate. The reaction provided, however, involves the exchange of dADP and dTTP, which is not related to the activity or function of the gene described. Therefore, the gene and the reaction are not related based on their distinct biochemical roles.	No
ENSG00000125454	Q9HC21	MAR07839: dATP + dUDP --> dATP + dUDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 is involved in the mitochondrial transport of thiamine diphosphate, mediating its uptake into mitochondria. The catalytic activity of this gene involves the exchange between thiamine diphosphate and thiamine phosphate. The reaction provided (dATP + dUDP --> dATP + dUDP) does not involve thiamine diphosphate, thiamine phosphate, or the mitochondrial transport process. Therefore, the gene and the reaction are not related.	No
ENSG00000125454	Q9HC21	MAR07840: dCDP + dTTP --> dCDP + dTTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The annotated gene ENSG00000125454 encodes a mitochondrial transporter that mediates the uptake of thiamine diphosphate into mitochondria and catalyzes the exchange of thiamine diphosphate and thiamine phosphate. However, the reaction provided (dCDP + dTTP --> dCDP + dTTP) involves nucleotides and is unrelated to the transport or exchange of thiamine derivatives, indicating no direct connection between the gene's function and the given reaction.	No
ENSG00000125454	Q9HC21	MAR07841: dCDP + dCTP --> dCDP + dCTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 encodes a mitochondrial transporter that mediates the uptake of thiamine diphosphate into mitochondria and catalyzes a reaction involving thiamine diphosphate and thiamine phosphate. In contrast, the reaction provided (dCDP + dCTP --> dCDP + dCTP) involves nucleotide substrates and is unrelated to the thiamine diphosphate transport function of the gene product. Thus, the gene and the reaction are not related.	No
ENSG00000125454	Q9HC21	MAR07842: dCTP + dUDP --> dCTP + dUDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 is involved in the mitochondrial uptake of thiamine diphosphate, functioning as a transporter for thiamine diphosphate and thiamine phosphate. The catalytic activity described involves the exchange of thiamine diphosphate and thiamine phosphate inside and outside of the mitochondria. However, the provided reaction involves the conversion of dCTP and dUDP, which is not related to thiamine diphosphate transport or metabolism. Therefore, the function of the gene is not relevant to the provided reaction.	No
ENSG00000125454	Q9HC21	MAR07843: dCTP + dGDP --> dCTP + dGDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter involved in the uptake of thiamine diphosphate into mitochondria and mediates the antiport of thiamine diphosphate and thiamine phosphate. The provided reaction, "dCTP + dGDP --> dCTP + dGDP," involves nucleotide exchange and has no connection to the transport or metabolism of thiamine diphosphate or thiamine phosphate. Therefore, the function of the gene is unrelated to the given reaction.	No
ENSG00000125454	Q9HC21	MAR07845: ADP + dCTP --> ADP + dCTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter that mediates the uptake of thiamine diphosphate into mitochondria and facilitates a specific antiporter reaction involving thiamine diphosphate and thiamine phosphate. The annotated catalytic activity describes a reaction involving thiamine compounds, while the provided reaction (ADP + dCTP --> ADP + dCTP) is unrelated to this function and involves different substrates (ADP and dCTP), indicating no direct connection between the gene's function and the reaction provided.	No
ENSG00000125454	Q9HC21	MAR07846: ATP + dCTP --> ATP + dCTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. Based on the provided annotation, the gene ENSG00000125454 encodes a mitochondrial transporter that mediates the uptake of thiamine diphosphate into mitochondria and is involved in the exchange of thiamine diphosphate and thiamine phosphate across the mitochondrial membrane. The reaction listed, "ATP + dCTP --> ATP + dCTP," is unrelated to the transport and exchange functions of thiamine diphosphate and thiamine phosphate, and therefore, the gene and the reaction are not related.	No
ENSG00000125454	Q9HC21	MAR07847: dADP + dGTP --> dADP + dGTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter involved in the exchange of thiamine diphosphate and thiamine phosphate across the mitochondrial membrane. The described function and catalytic activity are specific to thiamine diphosphate transport, while the reaction provided (dADP + dGTP --> dADP + dGTP) is unrelated and does not involve any components or processes associated with thiamine metabolism or mitochondrial transport as described for this gene.	No
ENSG00000125454	Q9HC21	MAR07849: dGTP + dUDP --> dGTP + dUDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter that mediates the uptake of thiamine diphosphate into mitochondria and catalyzes the exchange between thiamine diphosphate and thiamine phosphate. The provided reaction involves dGTP and dUDP, which are nucleotides, and there is no connection to thiamine diphosphate or thiamine phosphate. Therefore, the gene¡¯s function and its catalytic activity are not related to the reaction involving dGTP and dUDP.	No
ENSG00000125454	Q9HC21	MAR07850: dGTP + dTDP --> dGTP + dTDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter responsible for mediating the uptake of thiamine diphosphate into mitochondria. The catalytic activity described for this gene involves the exchange of thiamine diphosphate and thiamine phosphate. However, the reaction provided (dGTP + dTDP --> dGTP + dTDP) does not involve thiamine diphosphate or thiamine phosphate, and is instead related to nucleotide metabolism, which does not align with the function or catalytic activity of the gene mentioned. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000125454	Q9HC21	MAR07851: dGDP + dGTP --> dGDP + dGTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 encodes a mitochondrial transporter that is specifically involved in the uptake of thiamine diphosphate into mitochondria and functions as an antiporter for thiamine diphosphate and thiamine phosphate. The provided reaction, dGDP + dGTP --> dGDP + dGTP, does not involve thiamine diphosphate or thiamine phosphate and is unrelated to the function or catalytic activity of the gene's product. Therefore, the gene and the reaction are not related.	No
ENSG00000125454	Q9HC21	MAR07852: dCDP + dGTP --> dCDP + dGTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The annotated function of the gene ENSG00000125454 indicates it is a mitochondrial transporter mediating the uptake of thiamine diphosphate into mitochondria, with specific catalytic activity related to the exchange of thiamine diphosphate and thiamine phosphate. The reaction described (dCDP + dGTP --> dCDP + dGTP) involves different substrates (dCDP and dGTP) and does not align with the gene's annotated function or catalytic activity which revolves around thiamine derivatives rather than deoxycytidine diphosphate or deoxyguanosine triphosphate. Thus, the gene does not pertain to the provided reaction.	No
ENSG00000125454	Q9HC21	MAR07853: dATP + dGDP --> dATP + dGDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 encodes a mitochondrial transporter that mediates the uptake of thiamine diphosphate into mitochondria, facilitating an antiporter activity involving thiamine diphosphate and thiamine phosphate. However, the provided reaction describes the conversion of dATP and dGDP, which is unrelated to the function of the mitochondrial transporter specified by the gene, as it does not involve thiamine diphosphate, thiamine phosphate, or the antiporter activity described.	No
ENSG00000125454	Q9HC21	MAR07854: dADP + dATP --> dADP + dATP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter that mediates the uptake of thiamine diphosphate into mitochondria and acts as an antiporter exchanging thiamine diphosphate and thiamine phosphate. In contrast, the provided reaction involves the conversion between dADP and dATP, which is unrelated to the thiamine diphosphate/thiamine phosphate transport function of the gene's product.	No
ENSG00000183048	Q9UBX3	MAR08742: fumarate + sulfate <=> fumarate + sulfate	ENSG00000183048	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000183048 catalyzes the exchange of metabolites such as malate, malonate, succinate, sulfate, and phosphate, as evidenced by multiple catalytic activities involving these compounds. The provided reaction involves fumarate and sulfate, a reaction not mentioned in the gene's annotated catalytic activities. Hence, the gene is not relevant to the reaction involving fumarate and sulfate.	Yes, fumarate belongs to dicarboxylates which can be exchanged by this transporter.
ENSG00000130821	P48029	MAR03008: ATP + H2O + propanoyl-CoA --> ADP + H+ + Pi + propanoyl-CoA	ENSG00000067829 or ENSG00000067840 or ENSG00000101986 or ENSG00000130821 or ENSG00000130822 or ENSG00000184343 or ENSG00000185825	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000130821 encodes a creatine:sodium symporter involved in mediating the uptake of creatine, specifically facilitating the transport of creatine across the blood-brain barrier. The described catalytic activity for this gene involves the transport of chloride, creatine, and sodium ions. In contrast, the provided reaction involves the hydrolysis of ATP to ADP, H+, Pi, and propanoyl-CoA, which does not involve creatine, sodium ions, or chloride, and hence, is unrelated to the gene's annotated function and activity.	No
ENSG00000130821	P48029	MAR03011: ATP + H2O + palmitoyl-CoA --> ADP + H+ + palmitoyl-CoA + Pi	ENSG00000067829 or ENSG00000067840 or ENSG00000101986 or ENSG00000130821 or ENSG00000130822 or ENSG00000184343 or ENSG00000185825	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000130821 functions as a creatine:sodium symporter involved in the uptake of creatine, mediating the transport of creatine along with sodium and chloride ions across membranes. The reaction provided involves ATP hydrolysis and palmitoyl-CoA but does not mention the transport of creatine, sodium, or chloride ions. Therefore, there is no direct relevance between the gene function and the provided reaction.	No
ENSG00000130822	Q6P2M8	MAR03011: ATP + H2O + palmitoyl-CoA --> ADP + H+ + palmitoyl-CoA + Pi	ENSG00000067829 or ENSG00000067840 or ENSG00000101986 or ENSG00000130821 or ENSG00000130822 or ENSG00000184343 or ENSG00000185825	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000130822 encodes for a calcium/calmodulin-dependent protein kinase, which primarily phosphorylates proteins at serine and threonine residues using ATP, consistent with the provided catalytic activities. However, the reaction described involves the hydrolysis of ATP and the production of ADP, H+, palmitoyl-CoA, and Pi, which does not involve phosphorylation of serine or threonine residues or the substrates typically associated with this kinase. Hence, the gene's function does not align with the described reaction.	No
ENSG00000130821	P48029	MAR03013: ATP + H2O + linoleoyl-CoA --> ADP + H+ + linoleoyl-CoA + Pi	ENSG00000067829 or ENSG00000067840 or ENSG00000101986 or ENSG00000130821 or ENSG00000130822 or ENSG00000184343 or ENSG00000185825	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000130821 encodes a creatine:sodium symporter, which facilitates the uptake of creatine along with chloride and sodium ions, playing a significant role in creatine transport, specifically into the brain. However, the reaction described (ATP + H2O + linoleoyl-CoA --> ADP + H+ + linoleoyl-CoA + Pi) involves the hydrolysis of ATP in the presence of linoleoyl-CoA, which is unrelated to creatine transport or sodium symport mechanisms. Therefore, the gene's function does not correspond to the reaction provided.	No
ENSG00000184343	Q9UPE1	MAR03014: arachidonyl-CoA + ATP + H2O --> ADP + arachidonyl-CoA + H+ + Pi	ENSG00000067829 or ENSG00000067840 or ENSG00000101986 or ENSG00000130821 or ENSG00000130822 or ENSG00000184343 or ENSG00000185825	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000184343 encodes a serine/arginine-rich protein-specific kinase that specifically phosphorylates substrates at serine or threonine residues. Its function involves normal muscle development and phosphorylation of splicing factors and receptors but does not involve the reaction with arachidonyl-CoA, ATP, and water. The reaction described involves arachidonyl-CoA, ATP, water, and the production of ADP, arachidonyl-CoA, H+, and Pi, which indicates a different biochemical process not related to the phosphorylation functions of the gene described.	No
ENSG00000130821	P48029	MAR03017: (13Z)-eicosenoyl-CoA + ATP + H2O --> (13Z)-eicosenoyl-CoA + ADP + H+ + Pi	ENSG00000067829 or ENSG00000067840 or ENSG00000101986 or ENSG00000130821 or ENSG00000130822 or ENSG00000184343 or ENSG00000185825	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene, ENSG00000130821, is annotated to mediate the uptake of creatine as a creatine:sodium symporter. Its catalytic activity involves the transport of creatine, sodium, and chloride ions across membranes. However, the reaction specified (conversion of (13Z)-eicosenoyl-CoA, ATP, and water to ADP, H+, and Pi) does not involve creatine or relate to the gene's documented function in creatine transport. Therefore, they are not related.	No
ENSG00000108932	O15403	MAR04930: H+ + pyruvate <=> H+ + pyruvate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 is annotated for a function related to the transport of taurine across the plasma membrane, as indicated by its ability to mediate the facilitative efflux or influx of taurine. This function is further supported by the catalytic activity described, which involves the transport of taurine (taurine(out) = taurine(in)). However, the reaction provided (H+ + pyruvate <=> H+ + pyruvate) involves pyruvate and protons, which is unrelated to taurine transport. Therefore, the gene and the reaction do not share a functional relationship.	No
ENSG00000123643	Q7Z2H8	MAR05048: arginine --> arginine	ENSG00000123643	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000123643 encodes a protein that functions as an electrogenic proton/amino acid symporter, specifically involved in the transport of small apolar L-amino acids, their D-enantiomers, and certain amino acid derivatives across membranes. The provided reaction involves arginine and does not match any of the catalytic activities described for this gene, which include transport reactions for glycine, L-alanine, D-alanine, L-proline, D-proline, L-serine, D-serine, 4-aminobutanoate, and beta-alanine. Therefore, the gene's function does not relate to the conversion or transport of arginine.	No
ENSG00000123643	Q7Z2H8	MAR05051: cysteine --> cysteine	ENSG00000123643	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000123643 encodes a protein that functions as an electrogenic proton/amino acid symporter with selectivity for small apolar L-amino acids, their D-enantiomers, and certain amino acid derivatives, facilitating their transport across membranes. The annotated catalytic activities include symporting glycine, L-alanine, D-alanine, L-proline, D-proline, D-serine, L-serine, 4-aminobutanoate, and beta-alanine along with protons. However, the reaction "cysteine --> cysteine" does not involve proton symport or the transport of amino acids as described in the gene's functions. Therefore, there is no relevance or connection between the gene and the provided reaction involving cysteine.	No
ENSG00000123643	Q7Z2H8	MAR05062: tyrosine --> tyrosine	ENSG00000104044 or ENSG00000123643	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000123643 encodes a protein that functions as a proton/amino acid symporter, facilitating the transport of small apolar amino acids and their derivatives across membranes. The catalytic activities listed involve transporting specific amino acids like glycine, alanine, proline, serine, and aminobutanoate along with a proton gradient. However, the described reaction "tyrosine --> tyrosine" does not involve the transport or transformation of tyrosine, nor any of the amino acids mentioned in the gene's function. Thus, there is no direct relationship between the gene's annotated functions and the provided reaction.	No
ENSG00000130958	Q76EJ3	MAR00918: UDP-galactose + UMP <=> UDP-galactose + UMP	ENSG00000117620 or ENSG00000130958 or ENSG00000205060	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000130958 is involved in transporting UDP-GlcNAc and UDP-Glc across the Golgi membrane in exchange for UMP, as evidenced by the cited PubMed studies. The reaction provided involves UDP-galactose and UMP, which is not mentioned in the gene's annotated functions or catalytic activities. Therefore, the gene does not relate to the reaction involving UDP-galactose and UMP.	No
ENSG00000107819	Q9BWM7	MAR07759: citrulline <=> citrulline	ENSG00000107819	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000107819 encodes a mitochondrial serine transporter involved in the one-carbon metabolism pathway by mediating the transport of serine into mitochondria. However, the reaction described involves the conversion of citrulline to citrulline, which is unrelated to the transport or metabolism of serine and does not involve the mitochondrial serine transporter function. Therefore, the gene and the reaction are not related.	No
ENSG00000152779	Q6ZSM3	MAR08496: acetate <=> acetate	ENSG00000152779 or ENSG00000165449 or ENSG00000174327	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000152779 encodes a transporter protein involved in the transport of creatine and its precursor guanidinoacetate. It facilitates the movement of these molecules across membranes but does not catalyze the interconversion of acetate. The described gene function and catalytic activities pertain to creatine and guanidinoacetate transportation, not to any reaction involving acetate. Therefore, the gene is not associated with the reaction acetate <=> acetate.	No
ENSG00000165449	Q7RTY1	MAR08496: acetate <=> acetate	ENSG00000152779 or ENSG00000165449 or ENSG00000174327	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000165449 functions as a creatine and carnitine transporter based on its annotation. It catalyzes the transport of creatine and carnitine across membranes. However, the reaction provided involves the interconversion of acetate, which is not one of the substrates or products linked to this gene's catalytic activity, making the gene irrelevant to the given reaction.	No
ENSG00000117620	Q9Y2D2	MAR08857: UDP-glucose + UMP <=> UDP-glucose + UMP	ENSG00000117620 or ENSG00000130958 or ENSG00000205060	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene (ENSG00000117620) is involved in the transport and exchange of UDP-N-acetyl-alpha-D-glucosamine and UMP across the Golgi membrane. The catalytic activity described in the gene function specifically mentions UDP-N-acetyl-alpha-D-glucosamine and UMP, and not UDP-glucose. The reaction provided involves UDP-glucose and UMP, which does not match the substrate specificity of the gene product. Therefore, the gene and the reaction are not related.	No
ENSG00000135917	Q9BZV2	MAR00095: biotin + H+ --> biotin + H+	ENSG00000135917	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000135917 is involved in the uptake of thiamine and pyridoxine via proton anti-port mechanisms, as well as H(+)-dependent pyridoxine transport. It has no activity related to folate transport. The reactions it mediates involve thiamine and pyridoxine transport, not biotin. The reaction provided involves biotin and H+, which is not mentioned in the function or catalytic activities of this gene. Therefore, the gene and the reaction are not related.	No
ENSG00000103569	O43315	MAR01485: L-lactate --> L-lactate	ENSG00000103569	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103569 forms a water channel involved in the passage of various small, non-charged solutes like glycerol, urea, polyols, purines, and pyrimidines, as stated in its function. However, it shows no catalytic activity and does not facilitate reactions involving L-lactate. The reaction provided, L-lactate to L-lactate, does not align with the gene's described function, which does not mention involvement in lactate metabolism or transformation.	No
ENSG00000115902	P43007	MAR08972: glutamate + Na+ + proline --> glutamate + Na+ + proline	ENSG00000115902	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000115902 is responsible for the sodium-dependent transport of specific amino acids, including alanine, serine, cysteine, proline, hydroxyproline, and threonine. The reactions catalyzed by this gene involve the exchange of these amino acids across the membrane along with sodium ions. However, the reaction provided involves glutamate, which is not mentioned in the gene's annotated amino acids. Therefore, the gene does not relate to the reaction involving glutamate.	No
ENSG00000149150	O75387	MAR09274: kynurenine <=> kynurenine	ENSG00000149150 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149150 encodes a uniport transporter involved in the facilitated diffusion of neutral amino acids, such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine. The reaction provided (kynurenine <=> kynurenine) involves kynurenine, which is not one of the substrates mentioned in the gene's function or catalytic activities. Therefore, the gene does not mediate the transport of kynurenine and is not relevant to the given reaction.	No
ENSG00000167703	Q8N370	MAR09274: kynurenine <=> kynurenine	ENSG00000149150 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000167703 encodes a uniporter responsible for the transport of L-phenylalanine, L-methionine, and L-branched-chain amino acids such as L-leucine and L-isoleucine across cellular membranes via facilitated diffusion, as evidenced by multiple studies (PubMed:15659399, PubMed:30379325). The specific catalytic activities mentioned involve the transport of these amino acids in and out of the cell, which are not related to the reaction described here involving kynurenine. Therefore, the gene's function and known catalytic activities do not involve or affect the reaction involving the compound kynurenine.	No
ENSG00000005471	P21439	MAR09882: ATP + folate + H2O --> ADP + folate + H+ + Pi	ENSG00000005471 or ENSG00000023839 or ENSG00000103222 or ENSG00000114770 or ENSG00000118777 or ENSG00000121270 or ENSG00000125257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000005471 encodes for a protein involved in phospholipid translocation and bile formation in hepatocytes, mainly functioning as a phospholipid floppase. It catalyzes the ATP-dependent flipping of specific phospholipids (phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin) from the inner to the outer leaflet of the canalicular membrane bilayer. In contrast, the reaction provided involves the conversion of ATP and folate to ADP, folate, H+, and Pi, a process not associated with the phospholipid translocation or bile secretion activities described for the gene's product.	No
ENSG00000121270	Q96J66	MAR09882: ATP + folate + H2O --> ADP + folate + H+ + Pi	ENSG00000005471 or ENSG00000023839 or ENSG00000103222 or ENSG00000114770 or ENSG00000118777 or ENSG00000121270 or ENSG00000125257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000121270 encodes an ATP-dependent transporter that primarily mediates the efflux of various physiological compounds and xenobiotics. The documented catalytic activities focus on the transport of compounds like leukotriene C4, dehydroepiandrosterone 3-sulfate, estrone 3-sulfate, taurocholate, glycocholate, and nucleotide analogs. The provided reaction involves the conversion of ATP, folate, and H2O to ADP, folate, H+, and phosphate, which is not aligned with the specific substrates and processes attributed to the gene's function. Therefore, the gene does not appear to be linked to the provided reaction.	No
ENSG00000121270	Q96J66	MAR11383: 7alpha-hydroxycholest-4-en-3-one + ATP + H2O --> 7alpha-hydroxycholest-4-en-3-one + ADP + H+ + Pi	ENSG00000073734 or ENSG00000108846 or ENSG00000121270	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000121270 functions as an ATP-dependent transporter from the ABC family, actively extruding various physiological compounds and xenobiotics from cells. Its catalytic activities involve the ATP-dependent efflux of specific substrates such as leukotriene C4, steroid sulfates, glucuronides, bile acids, and others. However, the provided reaction involving the substrate 7alpha-hydroxycholest-4-en-3-one does not align with the substrates listed in the gene's known functions and catalytic activities. Thus, the gene is not relevant to the reaction provided.	Yes, 7alpha-hydroxycholest-4-en-3-one is a bile acid precursor or related metabolite, belonging to the fat-soluble compound
ENSG00000085563	P08183	MAR11768: ATP + H2O + pregnenolone --> ADP + H+ + Pi + pregnenolone	ENSG00000085563	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000085563 encodes for a protein that primarily functions as a translocator of drugs and phospholipids across the membrane, utilizing ATP hydrolysis to transport substrates such as phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides, and sphingomyelins. The provided reaction, which involves the conversion of ATP and H2O with pregnenolone to ADP, H+, Pi, and pregnenolone, does not match any of the catalytic activities or substrates specified for the protein encoded by this gene. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000174669	Q14542	MAR11801: quinonoid dihydrobiopterin <=> quinonoid dihydrobiopterin	ENSG00000112759 or ENSG00000174669	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000174669 is a bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, helping to maintain their cellular homeostasis. It functions as a Na(+)-independent passive transporter, facilitating the transport of various nucleosides (inosine, adenosine, uridine, thymidine, cytidine, and guanosine) and nucleobases. It specifically mediates the influx and efflux of these molecules in various tissues, contributing to processes such as nucleoside uptake in kidney cells and Sertoli cells. However, the reaction involving "quinonoid dihydrobiopterin <=> quinonoid dihydrobiopterin" is unrelated to the gene's function as outlined. This reaction does not involve the transport of nucleosides or nucleobases, hence the gene is not relevant to the provided reaction.	No
ENSG00000015520	Q9UHC9	MAR11815: calcitriol --> calcitriol	ENSG00000015520 or ENSG00000073060 or ENSG00000135218	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000015520 is involved in cholesterol homeostasis, the uptake of cholesterol, and the transport of sitosterol, and has specific catalytic activities related to these processes. However, the reaction provided involves the conversion of calcitriol, which is not mentioned in the gene's function or catalytic activities. Thus, the gene and the reaction are not related.	No
ENSG00000073734	O95342	MAR12184: ATP + H2O + Coprostanol --> ADP + H+ + Pi + Coprostanol	ENSG00000023839 or ENSG00000073734 or ENSG00000108846 or ENSG00000125257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000073734 encodes a protein involved in the ATP-dependent transport of bile salts and other compounds such as pravastatin, which is crucial for hepatic bile acid homeostasis and biliary excretion. However, the provided reaction involves the conversion of ATP, H2O, and Coprostanol to ADP, H+, Pi, and Coprostanol. This reaction does not involve bile salts or the substrates specifically transported by the gene product, indicating no relevance between the gene and the reaction.	No
ENSG00000186198	Q86UW2	MAR12185: HCO3- + Coprostanol <=> HCO3- + Coprostanol	ENSG00000111700 or ENSG00000134538 or ENSG00000163959 or ENSG00000186198	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. While the gene ENSG00000186198 is involved in the transport of bile acids, steroids, eicosanoids, and other related compounds across the basolateral membrane of enterocytes, the provided reaction involves the interconversion of bicarbonate (HCO3-) and coprostanol. This specific reaction is not mentioned among the catalytic activities associated with ENSG00000186198, indicating that the gene is not related to this particular reaction.	No
ENSG00000113396	Q9Y2P4	MAR00164: valeric acid <=> valeric acid	ENSG00000113396 or ENSG00000121769 or ENSG00000130304 or ENSG00000135218 or ENSG00000143554 or ENSG00000145384 or ENSG00000163586 or ENSG00000164434 or ENSG00000164687 or ENSG00000167114 or ENSG00000170231 or ENSG00000170323 or ENSG00000197416 or ENSG00000205186	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000113396 is known for facilitating the transport and activation of long-chain fatty acids (LCFA) and very-long-chain fatty acids (VLCFA) into their corresponding acyl-CoA derivatives, largely supporting beta-oxidation processes. The specific catalytic activities listed, such as the import and activation of hexadecanoate, octadecenoate, and other fatty acids with ATP and CoA, are not related to the reaction involving valeric acid. Valeric acid, a short-chain fatty acid, does not fall under the substrates specified in the gene's described functions and catalytic activities, indicating no relevant connection.	No
ENSG00000104267	P00918	MAR00190: ATP + H2O + lauric acid --> ADP + H+ + lauric acid + Pi	ENSG00000074410 or ENSG00000104267 or ENSG00000107159 or ENSG00000118298 or ENSG00000131686 or ENSG00000133742 or ENSG00000159593 or ENSG00000164879 or ENSG00000165029 or ENSG00000166747 or ENSG00000167434 or ENSG00000168748 or ENSG00000169239 or ENSG00000174990 or ENSG00000185015	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000104267 encodes an enzyme that catalyzes the reversible hydration of carbon dioxide and the hydration of cyanamide to urea. It does not catalyze reactions involving ATP, lauric acid, ADP, H+, and Pi as specified in the provided reaction. Therefore, the gene's annotated functions do not correlate with the reaction described.	No
ENSG00000118298	Q9ULX7	MAR00190: ATP + H2O + lauric acid --> ADP + H+ + lauric acid + Pi	ENSG00000074410 or ENSG00000104267 or ENSG00000107159 or ENSG00000118298 or ENSG00000131686 or ENSG00000133742 or ENSG00000159593 or ENSG00000164879 or ENSG00000165029 or ENSG00000166747 or ENSG00000167434 or ENSG00000168748 or ENSG00000169239 or ENSG00000174990 or ENSG00000185015	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000118298 encodes an enzyme that catalyzes the reversible hydration of carbon dioxide, converting carbon dioxide and water into hydrogen ions and bicarbonate. The provided reaction, however, involves the conversion of ATP, water, and lauric acid into ADP, a proton, lauric acid, and inorganic phosphate, which is unrelated to the hydration of carbon dioxide. Therefore, the gene and the reaction involve distinct biochemical processes.	No
ENSG00000165029	O95477	MAR00198: ATP + H2O + myristic acid --> ADP + H+ + myristic acid + Pi	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000165029 is involved in the translocation of specific phospholipids and cholesterol across membranes, coupled with ATP hydrolysis. It catalyzes the movement of phosphatidylcholine, phosphatidylserine, sphingomyelin, and cholesterol, but there is no evidence it is involved in the reaction ATP + H2O + myristic acid --> ADP + H+ + myristic acid + Pi. The provided gene annotation does not mention any catalytic activity or function related to myristic acid.	No

[hhl-24]

All of these seem fine to me.