GPR curation for Transport reactions (11)

[JHL-452b]

Current behavior:

50 genes are discovered to be uncorrelated with their corresponding reactions in Transport reactions.

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000059804	P11169	MAR08586: maltose <=> maltose	ENSG00000059804	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000059804 encodes a facilitative glucose transporter, which mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose, fucose, and probably also dehydroascorbate. The described reactions include the transport of D-glucose and D-galactose across the cell membrane. However, the reaction provided involves maltose, which is not a substrate mentioned in the gene's function or catalytic activity. Thus, the gene is not related to the maltose reaction.	No
ENSG00000103064	Q92536	MAR08687: cystine + serine --> cystine + serine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 functions as an antiporter that primarily exports cationic amino acids like L-arginine in exchange for neutral amino acids such as L-leucine, L-glutamine, and sodium ions. The reactions catalyzed by this gene involve various amino acids and sodium ions, none of which correspond to the reaction "cystine + serine --> cystine + serine." Therefore, the gene's function does not match the provided reaction.	No
ENSG00000117834	Q2M3M2	MAR08876: galactose + Na+ --> galactose + Na+	ENSG00000117834	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000117834 encodes an electrogenic Na(+)-coupled sugar symporter that primarily transports D-mannose, and possibly D-fructose and D-glucose, driven by a transmembrane Na(+) electrochemical gradient. The gene's function relates to recognizing sugar substrates with a pyranose ring having an axial hydroxyl group on carbon 2. The provided reaction involves the transport of galactose with Na(+), which does not match the substrates (D-mannose, D-fructose, and D-glucose) specified for the symporter activity of the gene. Therefore, the gene is not related to the reaction involving galactose and Na(+).	No
ENSG00000066230	P48764	MAR08925: Na+ + NH3 --> Na+ + NH3	ENSG00000066230 or ENSG00000090020 or ENSG00000115616	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000066230 encodes a Na(+)/H(+) antiporter involved in exchanging intracellular H(+) for extracellular Na(+), crucial for pH homeostasis and salt absorption. The provided reaction, Na+ + NH3 --> Na+ + NH3, does not involve H(+) ions or any exchange mechanism, making it unrelated to the gene's annotated function.	No
ENSG00000115616	Q9UBY0	MAR08925: Na+ + NH3 --> Na+ + NH3	ENSG00000066230 or ENSG00000090020 or ENSG00000115616	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000115616 encodes a plasma membrane Na(+)/H(+) antiporter which mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) ions. However, the reaction provided (Na+ + NH3 --> Na+ + NH3) does not involve any exchange of H(+) ions but rather involves Na+ and NH3, which is not related to the function of the Na(+)/H(+) antiporter described for the gene.	No
ENSG00000090020	P19634	MAR08925: Na+ + NH3 --> Na+ + NH3	ENSG00000066230 or ENSG00000090020 or ENSG00000115616	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000090020 encodes for an electroneutral Na(+)/H(+) antiporter, which exchanges Na(+) and H(+) ions to maintain intracellular pH and cell volume. Additionally, it can function as a Na(+)/Li(+) antiporter. However, the reaction provided (Na+ + NH3 --> Na+ + NH3) does not involve the exchange of H(+), Na(+), or Li(+) ions, and thus is unrelated to the functions described for this gene.	No
ENSG00000113396	Q9Y2P4	MAR08941: Na+ + stearate --> Na+ + stearate	ENSG00000113396 or ENSG00000130304 or ENSG00000143554 or ENSG00000167114	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000113396 is involved in the import and activation of long-chain and very-long-chain fatty acids into their coenzyme A derivatives, facilitating their transport across the plasma membrane and their subsequent metabolism. It specifically mediates reactions involving fatty acids, ATP, and CoA to form fatty acyl-CoA. However, the provided reaction (Na+ + stearate --> Na+ + stearate) does not involve the transport or activation of fatty acids but rather a simple ionic interaction involving sodium and stearate, which falls outside the functional scope of the gene's described catalytic activities.	No
ENSG00000196517	P48067	MAR09591: alanine + chloride + 2.0 Na+ --> alanine + chloride + 2.0 Na+	ENSG00000196517 or ENSG00000268104	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000196517 encodes a sodium- and chloride-dependent glycine transporter. The described catalytic activity for the isoforms GlyT-1B and GlyT-1C involves the transport of glycine along with sodium and chloride ions across the cell membrane. However, the provided reaction involves alanine along with sodium and chloride ions, which is not consistent with the glycine transport activity associated with the gene. Therefore, the gene is not related to the reaction involving alanine.	No
ENSG00000196517	P48067	MAR09592: arginine + chloride + 2.0 Na+ --> arginine + chloride + 2.0 Na+	ENSG00000196517 or ENSG00000268104	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000196517 encodes a sodium- and chloride-dependent glycine transporter that regulates glycine concentrations at inhibitory glycinergic synapses. Its catalytic activity involves the transport of glycine, chloride, and sodium ions. The provided reaction involves arginine, chloride, and sodium ions, which are unrelated to the substrate specificity of the glycine transporter encoded by this gene. Therefore, the gene is not associated with the provided reaction.	No
ENSG00000196517	P48067	MAR09593: chloride + histidine + 2.0 Na+ --> chloride + histidine + 2.0 Na+	ENSG00000196517 or ENSG00000268104	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000196517 is annotated as encoding a sodium- and chloride-dependent glycine transporter, which is specifically involved in the transportation of glycine along with sodium and chloride ions across synaptic membranes. The provided catalytic activity details further support this function, where the reaction involves glycine, chloride, and sodium ions. In contrast, the reaction provided involves chloride, histidine, and sodium ions, indicating a different substrate (histidine instead of glycine) and implying a different transporter or enzymatic process. Therefore, the gene ENSG00000196517 does not relate to the reaction involving histidine.	No
ENSG00000196517	P48067	MAR09594: chloride + isoleucine + 2.0 Na+ --> chloride + isoleucine + 2.0 Na+	ENSG00000196517 or ENSG00000268104	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000196517 encodes for a sodium- and chloride-dependent glycine transporter essential for regulating glycine concentrations at inhibitory glycinergic synapses. The annotated catalytic activities involve the transport of glycine along with sodium and chloride ions. However, the provided reaction mentions isoleucine, not glycine, indicating that the reaction pertains to a different substrate and process. Thus, the gene and the reaction are not related.	No
ENSG00000196517	P48067	MAR09595: chloride + leucine + 2.0 Na+ --> chloride + leucine + 2.0 Na+	ENSG00000196517 or ENSG00000268104	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000196517 encodes the sodium- and chloride-dependent glycine transporter, which is involved in the transport of glycine across cell membranes along with sodium and chloride ions. However, the reaction provided involves chloride, leucine, and sodium ions, not glycine. Therefore, the gene and the reaction are not related.	No
ENSG00000196517	P48067	MAR09598: chloride + 2.0 Na+ + valine --> chloride + 2.0 Na+ + valine	ENSG00000196517 or ENSG00000268104	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000196517 encodes a sodium- and chloride-dependent glycine transporter, which is responsible for the transport of glycine across cellular membranes. The annotated catalytic activity specifies the transport of chloride, glycine, and sodium ions. However, the reaction provided involves the transport of valine, which is not a substrate for the glycine transporter specified by the gene. Therefore, the gene and the reaction are not related.	No
ENSG00000196517	P48067	MAR09599: chloride + cysteine + 2.0 Na+ --> chloride + cysteine + 2.0 Na+	ENSG00000196517 or ENSG00000268104	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000196517 encodes for a sodium- and chloride-dependent glycine transporter, which is involved in the transport of glycine across synaptic membranes. The specific catalytic activity of the gene involves the transport of chloride, glycine, and sodium ions, precisely as follows: chloride(out) + glycine(out) + 2 Na+(out) = chloride(in) + glycine(in) + 2 Na+(in). However, the reaction provided involves the transport of chloride, cysteine, and sodium ions, which differs from the function and substrate specificity of the glycine transporter encoded by ENSG00000196517. Therefore, the gene and the reaction are not related.	No
ENSG00000196517	P48067	MAR09600: chloride + 2.0 Na+ + serine --> chloride + 2.0 Na+ + serine	ENSG00000196517 or ENSG00000268104	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000196517 encodes for a sodium- and chloride-dependent glycine transporter, which facilitates the transport of glycine along with sodium and chloride ions. The given reaction involving chloride, sodium, and serine does not pertain to the transport of glycine, thus making the gene irrelevant to this specific reaction.	No
ENSG00000196517	P48067	MAR09601: beta-alanine + chloride + 2.0 Na+ --> beta-alanine + chloride + 2.0 Na+	ENSG00000131389 or ENSG00000196517 or ENSG00000268104	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000196517 encodes a sodium- and chloride-dependent glycine transporter involved in regulating glycine concentrations at inhibitory glycinergic synapses. The annotated catalytic activity specifically describes the transport of glycine along with sodium and chloride ions across the membrane. However, the provided reaction involves the transport of beta-alanine along with sodium and chloride ions, which does not correspond to the function or catalytic activity of the glycine transporter encoded by the gene ENSG00000196517. Therefore, the gene and the reaction are not related.	No
ENSG00000170522	Q9H5J4	MAR00158: butyryl-CoA + L-carnitine <=> butyryl-CoA + L-carnitine	ENSG00000012660 or ENSG00000026652 or ENSG00000100344 or ENSG00000102125 or ENSG00000111684 or ENSG00000123684 or ENSG00000125505 or ENSG00000141446 or ENSG00000143797 or ENSG00000146648 or ENSG00000151093 or ENSG00000160216 or ENSG00000169359 or ENSG00000170522 or ENSG00000171320 or ENSG00000176454 or ENSG00000186792 or ENSG00000197977	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000170522 encodes an enzyme that catalyzes the elongation of long- and very long-chain fatty acids by adding 2 carbons to the chain. Its function involves multiple specific catalytic activities associated with various acyl-CoA substrates and malonyl-CoA. However, the provided reaction involves the reversible interaction between butyryl-CoA and L-carnitine, which is not related to the fatty acid elongation process the gene's product is responsible for. Therefore, there is no relevance between the gene and the provided reaction.	No
ENSG00000026652	Q9NRZ5	MAR00158: butyryl-CoA + L-carnitine <=> butyryl-CoA + L-carnitine	ENSG00000012660 or ENSG00000026652 or ENSG00000100344 or ENSG00000102125 or ENSG00000111684 or ENSG00000123684 or ENSG00000125505 or ENSG00000141446 or ENSG00000143797 or ENSG00000146648 or ENSG00000151093 or ENSG00000160216 or ENSG00000169359 or ENSG00000170522 or ENSG00000171320 or ENSG00000176454 or ENSG00000186792 or ENSG00000197977	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000026652 encodes an enzyme that converts 1-acyl-sn-glycerol-3-phosphate into 1,2-diacyl-sn-glycerol-3-phosphate by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. It has high specificity for polyunsaturated fatty acyl-CoA, such as docosahexaenoyl-CoA, and is involved in various reactions with different fatty acyl-CoA and glycerol-3-phosphates. Meanwhile, the provided reaction involves butyryl-CoA and L-carnitine, which is unrelated to the gene's annotated function and catalytic activities.	No
ENSG00000125505	Q96N66	MAR00158: butyryl-CoA + L-carnitine <=> butyryl-CoA + L-carnitine	ENSG00000012660 or ENSG00000026652 or ENSG00000100344 or ENSG00000102125 or ENSG00000111684 or ENSG00000123684 or ENSG00000125505 or ENSG00000141446 or ENSG00000143797 or ENSG00000146648 or ENSG00000151093 or ENSG00000160216 or ENSG00000169359 or ENSG00000170522 or ENSG00000171320 or ENSG00000176454 or ENSG00000186792 or ENSG00000197977	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125505 encodes an acyltransferase that catalyzes the transfer of acyl groups from acyl-CoA to lysophosphatidylinositol and related molecules, primarily involved in phospholipid remodeling and the regulation of triglyceride metabolism. The mentioned enzymatic reactions specifically involve the formation of phosphatidylinositol and related compounds. On the other hand, the provided reaction involves the transfer of butyryl groups between butyryl-CoA and L-carnitine, which is unrelated to the acyltransferase activities of the gene ENSG00000125505.	No
ENSG00000197977	Q9NXB9	MAR00158: butyryl-CoA + L-carnitine <=> butyryl-CoA + L-carnitine	ENSG00000012660 or ENSG00000026652 or ENSG00000100344 or ENSG00000102125 or ENSG00000111684 or ENSG00000123684 or ENSG00000125505 or ENSG00000141446 or ENSG00000143797 or ENSG00000146648 or ENSG00000151093 or ENSG00000160216 or ENSG00000169359 or ENSG00000170522 or ENSG00000171320 or ENSG00000176454 or ENSG00000186792 or ENSG00000197977	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000197977 encodes an enzyme that catalyzes the elongation of long-chain and very long-chain fatty acids, specifically targeting polyunsaturated acyl-CoA substrates. The gene's catalytic activity involves the addition of two carbons to these fatty acid chains, including various specific reactions involving different polyunsaturated fatty acids and malonyl-CoA. The reaction provided, which involves butyryl-CoA and L-carnitine, does not match any of the specific reactions mentioned for this gene. Thus, the gene and the reaction are not related.	No
ENSG00000123684	Q92604	MAR00158: butyryl-CoA + L-carnitine <=> butyryl-CoA + L-carnitine	ENSG00000012660 or ENSG00000026652 or ENSG00000100344 or ENSG00000102125 or ENSG00000111684 or ENSG00000123684 or ENSG00000125505 or ENSG00000141446 or ENSG00000143797 or ENSG00000146648 or ENSG00000151093 or ENSG00000160216 or ENSG00000169359 or ENSG00000170522 or ENSG00000171320 or ENSG00000176454 or ENSG00000186792 or ENSG00000197977	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000123684 encodes an enzyme involved in the transfer and esterification of fatty acids within glycerophospholipids and monoacylglycerols. It is implicated in processes related to fatty acyl chain remodeling, particularly in the endoplasmic reticulum membrane. The reactions it catalyzes predominantly involve acyl-CoA derivatives and glycerophospholipids, facilitating the incorporation of long-chain saturated and unsaturated fatty acids. In contrast, the reaction provided involves the exchange between butyryl-CoA and L-carnitine, which operates in a different metabolic context, primarily associated with carnitine metabolism and fatty acid oxidation, not phospholipid remodeling. Hence, the gene's function does not align with the provided biochemical reaction.	No
ENSG00000186792	O43820	MAR00158: butyryl-CoA + L-carnitine <=> butyryl-CoA + L-carnitine	ENSG00000012660 or ENSG00000026652 or ENSG00000100344 or ENSG00000102125 or ENSG00000111684 or ENSG00000123684 or ENSG00000125505 or ENSG00000141446 or ENSG00000143797 or ENSG00000146648 or ENSG00000151093 or ENSG00000160216 or ENSG00000169359 or ENSG00000170522 or ENSG00000171320 or ENSG00000176454 or ENSG00000186792 or ENSG00000197977	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000186792 facilitates sperm penetration, induces the acrosome reaction in sperm, and is involved in follicular atresia and ovarian granulosa cell apoptosis. It exhibits catalytic activity involving the hydrolysis of hyaluronate, not the hydrolysis or transfer of butyryl-CoA and L-carnitine. Thus, the gene's annotated functions do not relate to the provided reaction involving butyryl-CoA and L-carnitine.	No
ENSG00000100344	Q9NST1	MAR00158: butyryl-CoA + L-carnitine <=> butyryl-CoA + L-carnitine	ENSG00000012660 or ENSG00000026652 or ENSG00000100344 or ENSG00000102125 or ENSG00000111684 or ENSG00000123684 or ENSG00000125505 or ENSG00000141446 or ENSG00000143797 or ENSG00000146648 or ENSG00000151093 or ENSG00000160216 or ENSG00000169359 or ENSG00000170522 or ENSG00000171320 or ENSG00000176454 or ENSG00000186792 or ENSG00000197977	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000100344 encodes an enzyme specifically involved in catalyzing the acylation of lysophosphatidic acid to generate phosphatidic acid, and it also possesses activities related to acyl-chain remodeling of triglycerides and phospholipase activity. These activities do not relate to the provided reaction involving butyryl-CoA and L-carnitine, indicating no relevance between the gene and the reaction.	No
ENSG00000165449	Q7RTY1	MAR05292: acetate <=> acetate	ENSG00000152779 or ENSG00000165449 or ENSG00000174327	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000165449 functions as a creatine and carnitine transporter, mediating the movement of creatine and carnitine across cellular membranes. The described reactions it catalyzes involve the transport of creatine and carnitine, but there is no mention of involvement in reactions related to acetate. Therefore, based on the gene's annotated function and catalytic activities, it does not participate in the reaction involving acetate.	No
ENSG00000100075	P53007	MAR06289: AKG + H+ + isocitrate --> AKG + H+ + isocitrate	ENSG00000100075	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000100075 is annotated as a mitochondrial electroneutral antiporter involved in the exchange of citrate with various other metabolites such as malate, isocitrate, phosphoenolpyruvate, cis-aconitate, maleate, and succinate. The annotated catalytic activities specify various exchange reactions in the mitochondria. However, the provided reaction AKG + H+ + isocitrate --> AKG + H+ + isocitrate does not describe an exchange process and involves alpha-ketoglutarate (AKG), which is not listed as a substrate or product in the annotated catalytic activities of this gene. Hence, the gene and the reaction are not related.	No
ENSG00000100075	P53007	MAR06296: cis-aconitate + H+ + oxalate --> cis-aconitate + H+ + oxalate	ENSG00000100075	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The annotation of the gene ENSG00000100075 indicates that it encodes a mitochondrial electroneutral antiporter involved in the exchange of citrate and other compounds across the mitochondrial membrane. It participates in multiple exchange reactions involving citrate and other molecules such as (S)-malate, isocitrate, succinate, cis-aconitate, trans-aconitate, phosphoenolpyruvate, and maleate. However, the reaction provided (cis-aconitate + H+ + oxalate --> cis-aconitate + H+ + oxalate) does not involve any of the substrate exchanges mediated by the antiporter according to the gene's annotated functions. Therefore, the gene is not relevant to the specified reaction.	No
ENSG00000125454	Q9HC21	MAR06332: ATP + dADP --> ATP + dADP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 is involved in mitochondrial transport, specifically mediating the uptake of thiamine diphosphate into mitochondria and demonstrating antiporter activity involving thiamine diphosphate and thiamine phosphate. However, the reaction provided involves the transfer of energy between ATP and dADP, which is unrelated to the gene's described functions. The catalytic activity and transport function of the gene do not intersect with the ATP and dADP reaction.	No
ENSG00000125454	Q9HC21	MAR06333: ATP + dGDP --> ATP + dGDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 encodes a mitochondrial transporter involved in the uptake and transport of thiamine diphosphate in exchange for thiamine phosphate. However, the reaction described (ATP + dGDP --> ATP + dGDP) involves nucleotide exchange, which is unrelated to the thiamine diphosphate transport function of the gene product. Therefore, the gene does not participate in the provided reaction.	No
ENSG00000125454	Q9HC21	MAR06334: ATP + dUDP --> ATP + dUDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter that mediates the uptake of thiamine diphosphate into mitochondria, and it participates in the antiporter activity involving the exchange of thiamine diphosphate and thiamine phosphate across the mitochondrial membrane. This function and associated catalytic activity have no relevance to the provided reaction, ATP + dUDP --> ATP + dUDP, which involves nucleotide metabolism and does not involve thiamine diphosphate or the specific transport activities mediated by the gene product.	No
ENSG00000125454	Q9HC21	MAR06336: ADP + dGDP --> ADP + dGDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 functions as a mitochondrial transporter mediating the uptake of thiamine diphosphate into mitochondria. It facilitates the exchange of thiamine diphosphate and thiamine phosphate across the mitochondrial membrane. However, the reaction ADP + dGDP --> ADP + dGDP mentioned does not involve thiamine diphosphate or its transportation, thus the gene's function is unrelated to the provided reaction.	No
ENSG00000125454	Q9HC21	MAR06337: ADP + dUDP --> ADP + dUDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter protein that mediates the uptake of thiamine diphosphate into mitochondria and exhibits antiporter activity by exchanging thiamine diphosphate and thiamine phosphate. The provided reaction (ADP + dUDP --> ADP + dUDP) does not involve thiamine diphosphate or thiamine phosphate and falls outside the described function of the gene, thus there is no direct relevance between the gene function and the reaction.	No
ENSG00000125454	Q9HC21	MAR06339: ATP + dGTP --> ATP + dGTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 encodes a mitochondrial transporter involved in the uptake and exchange of thiamine diphosphate and thiamine phosphate within mitochondria. However, the reaction provided (ATP + dGTP --> ATP + dGTP) involves nucleotide substrates that do not intersect with the function of the gene's product, which is specifically linked to thiamine cofactors. Therefore, the gene and the reaction are unrelated.	No
ENSG00000125454	Q9HC21	MAR06340: ATP + dUTP --> ATP + dUTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 encodes a mitochondrial transporter that mediates the uptake of thiamine diphosphate into mitochondria. It catalyzes the exchange of thiamine diphosphate with thiamine phosphate across the mitochondrial membrane. The reaction provided involves the conversion of ATP and dUTP, which is unrelated to the gene's function of transporting thiamine diphosphate and thiamine phosphate.	No
ENSG00000125454	Q9HC21	MAR06341: ADP + dATP --> ADP + dATP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 encodes a mitochondrial transporter mediating the uptake of thiamine diphosphate into mitochondria, operating via an antiporter mechanism involving thiamine diphosphate and thiamine phosphate. This gene's function and catalytic activity are specific to the transport and exchange of thiamine-derived compounds, whereas the reaction given in the question involves the exchange of ADP and dATP, which is unrelated to the gene's function or activities annotated in the provided information.	No
ENSG00000125454	Q9HC21	MAR06342: ADP + dGTP --> ADP + dGTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter responsible for the uptake of thiamine diphosphate into mitochondria and mediates the exchange of thiamine diphosphate and thiamine phosphate. The reaction associated with this gene is the exchange of thiamine diphosphate and thiamine phosphate, not the reaction ADP + dGTP --> ADP + dGTP. Therefore, the gene's function and annotated reaction do not relate to the given reaction.	No
ENSG00000125454	Q9HC21	MAR06343: ADP + dUTP --> ADP + dUTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter responsible for the uptake of thiamine diphosphate into mitochondria. The annotated reaction for this gene involves the transport of thiamine diphosphate and thiamine phosphate between the inside and outside of mitochondria. However, the reaction provided (ADP + dUTP --> ADP + dUTP) does not involve thiamine diphosphate or thiamine phosphate and is unrelated to the gene's annotated function. Therefore, the gene and the reaction are not related.	No
ENSG00000125454	Q9HC21	MAR07804: dADP + dCDP <=> dADP + dCDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter protein involved in the uptake of thiamine diphosphate into mitochondria, facilitating an antiporter activity that exchanges thiamine diphosphate and thiamine phosphate across the mitochondrial membrane. However, the reaction described as "dADP + dCDP <=> dADP + dCDP" involves nucleotide diphosphates and does not pertain to thiamine compounds, making the gene unrelated to this reaction.	No
ENSG00000125454	Q9HC21	MAR07810: dGDP + dUDP <=> dGDP + dUDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter involved in the uptake of thiamine diphosphate into mitochondria, specifically mediating the exchange reaction between thiamine diphosphate and thiamine phosphate. However, the provided reaction involves the molecules dGDP and dUDP, which are nucleotides, and has no relevance to the mitochondrial transporter activity or the exchange of thiamine diphosphate and thiamine phosphate. Thus, the gene and the reaction are not related.	No
ENSG00000125454	Q9HC21	MAR07812: dADP + dUDP <=> dADP + dUDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 encodes a mitochondrial transporter involved in the uptake of thiamine diphosphate into mitochondria, facilitating a thiamine diphosphate/thiamine phosphate exchange reaction. The specified reaction (dADP + dUDP <=> dADP + dUDP) does not involve thiamine diphosphate or thiamine phosphate, indicating no relevance to the gene¡¯s function or catalytic activity.	No
ENSG00000125454	Q9HC21	MAR07814: dCDP + dUDP <=> dCDP + dUDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 encodes a mitochondrial transporter involved in the uptake of thiamine diphosphate into mitochondria, facilitating an antiporter reaction that exchanges thiamine diphosphate and thiamine phosphate. The reaction provided (dCDP + dUDP <=> dCDP + dUDP) does not involve thiamine diphosphate, thiamine phosphate, or any related mitochondrial transport function, indicating no relevance to the gene's annotated activity.	No
ENSG00000125454	Q9HC21	MAR07818: dGDP + dTDP <=> dGDP + dTDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter that mediates the uptake of thiamine diphosphate into mitochondria, functioning specifically in a thiamine diphosphate/thiamine phosphate antiporter activity. The reaction provided, however, involves the conversion between dGDP and dTDP, which is unrelated to the function of the gene. Therefore, the gene and the reaction are not related.	No
ENSG00000125454	Q9HC21	MAR07822: dCDP + dTDP <=> dCDP + dTDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The function of the gene ENSG00000125454 involves mediating the uptake of thiamine diphosphate into mitochondria and facilitating the exchange between thiamine diphosphate and thiamine phosphate. The reaction provided, however, pertains to the equilibration between dCDP and dTDP, which are deoxyribonucleotide diphosphates. As such, the catalytic activity and function of this gene are unrelated to the specified reaction, indicating that this gene does not contribute to or affect the given reaction involving dCDP and dTDP.	No
ENSG00000125454	Q9HC21	MAR07824: dCDP + dGDP <=> dCDP + dGDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter that mediates the uptake of thiamine diphosphate into mitochondria and operates as an antiporter. It is involved in the catalytic activity of exchanging thiamine diphosphate and thiamine phosphate between inside and outside of mitochondria. The reaction described (dCDP + dGDP <=> dCDP + dGDP) involves different substrates and does not relate to thiamine diphosphate or thiamine phosphate, hence the gene is not relevant to this reaction.	No
ENSG00000125454	Q9HC21	MAR07826: ATP + dCDP --> ATP + dCDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 encodes a mitochondrial transporter involved in the uptake of thiamine diphosphate into mitochondria and mediates an antiporter activity involving thiamine diphosphate and thiamine phosphate. However, the reaction provided involves ATP and dCDP, which are not substrates or products related to the function of the gene-encoded mitochondrial transporter. Therefore, there is no connection between the gene's annotated function and the reaction ATP + dCDP --> ATP + dCDP.	No
ENSG00000125454	Q9HC21	MAR07828: dUDP + dUTP --> dUDP + dUTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 is responsible for encoding a mitochondrial transporter that mediates the uptake of thiamine diphosphate into mitochondria, with a specific function and catalytic activity related to thiamine phosphate and thiamine diphosphate exchange. However, the provided reaction "dUDP + dUTP --> dUDP + dUTP" does not involve thiamine diphosphate or thiamine phosphate, and instead pertains to nucleotides dUDP and dUTP, which are unrelated to the gene's annotated function and catalytic activity. Therefore, the gene is not related to the reaction.	No
ENSG00000125454	Q9HC21	MAR07829: dGDP + dUTP --> dGDP + dUTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 encodes a mitochondrial transporter involved in the uptake of thiamine diphosphate into mitochondria and functions as an antiporter for thiamine diphosphate and thiamine phosphate. However, the provided reaction involves the conversion of dGDP and dUTP, which is unrelated to the function and catalytic activity described for the gene. Therefore, the gene is not relevant to the reaction.	No
ENSG00000125454	Q9HC21	MAR07830: dATP + dCDP --> dATP + dCDP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter involved in the uptake and transport of thiamine diphosphate within mitochondria. The described catalytic activity of the gene involves the exchange of thiamine diphosphate and thiamine phosphate between the mitochondrial matrix and the cytosol. However, the provided reaction, which involves the conversion of dATP and dCDP without any indication of thiamine-related compounds, is unrelated to the gene's function. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000125454	Q9HC21	MAR07832: dCDP + dUTP --> dCDP + dUTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter that mediates uptake of thiamine diphosphate into mitochondria, facilitating an exchange reaction involving thiamine diphosphate and thiamine phosphate. The provided reaction, "dCDP + dUTP --> dCDP + dUTP," involves nucleotide metabolism and does not pertain to thiamine transport or metabolism. Therefore, the gene and the reaction are not related.	No
ENSG00000125454	Q9HC21	MAR07833: ATP + dTTP --> ATP + dTTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter involved in the uptake of thiamine diphosphate into mitochondria. It facilitates the transfer of thiamine diphosphate and thiamine phosphate across the mitochondrial membrane. However, the reaction provided (ATP + dTTP --> ATP + dTTP) does not involve thiamine diphosphate or thiamine phosphate and is not related to the transport function of the gene described. Therefore, the gene and the reaction are not related.	No
ENSG00000125454	Q9HC21	MAR07834: ADP + dTTP --> ADP + dTTP	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 encodes a mitochondrial transporter involved in the uptake of thiamine diphosphate into mitochondria. Its associated catalytic activity involves the exchange of thiamine diphosphate and thiamine phosphate. However, the reaction provided (ADP + dTTP --> ADP + dTTP) does not involve thiamine diphosphate or the described transporter activity, thus they are not related.	No

[hhl-24]

All of these seem fine to me.