GPR curation for Transport reactions (10)

[JHL-452b]

Current behavior:

50 genes are discovered to be uncorrelated with their corresponding reactions in Transport reactions.

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000141526	O15427	MAR06037: formate + propanoate <=> formate + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 is annotated as encoding a proton-dependent transporter specific for monocarboxylates, such as L-lactate and pyruvate, facilitating their transport across the cell membrane. The described reactions for this gene involve lactate and pyruvate transport coupled with proton movement. However, the reaction provided (formate + propanoate <=> formate + propanoate) does not involve lactate, pyruvate, or proton transport, and thus is not related to the function of the gene ENSG00000141526.	No
ENSG00000108932	O15403	MAR06038: formate + L-lactate <=> formate + L-lactate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 is annotated to encode a monocarboxylate transporter that is selective for taurine, facilitating its transport across the plasma membrane. This transport mechanism is specific for taurine and operates in a pH- and sodium-independent manner. In contrast, the reaction provided involves the interconversion of formate and L-lactate, which is unrelated to the function of the taurine transporter. Therefore, the gene and the reaction are not related.	No
ENSG00000108932	O15403	MAR06039: butyrate + formate <=> butyrate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes a monocarboxylate transporter that specifically mediates the transport of taurine across the plasma membrane. This transport is pH- and sodium-independent. The provided reaction involves butyrate and formate, which are different compounds than taurine, indicating that the gene's function does not correlate with the provided reaction.	No
ENSG00000141526	O15427	MAR06039: butyrate + formate <=> butyrate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a proton-dependent transporter that specifically catalyzes the transport of monocarboxylates such as L-lactate and pyruvate, as described in the provided function and catalytic activity details. However, the reaction mentioned involves butyrate and formate, which are not substrates for the transporter encoded by this gene. Therefore, based on the given annotation, the gene and the reaction are not related.	No
ENSG00000118596	O60669	MAR06039: butyrate + formate <=> butyrate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000118596 encodes for a proton-coupled monocarboxylate symporter involved in the transport of monocarboxylates such as L-lactate, pyruvate, ketone bodies, acetoacetate, beta-hydroxybutyrate, and acetate across the plasma membrane. The gene's function pertains to various monocarboxylate transport reactions, but the reaction provided, "butyrate + formate <=> butyrate + formate", does not involve any of the substrates or products related to the gene's annotated functions. Therefore, there is no correlation between the gene and the given reaction.	No
ENSG00000108932	O15403	MAR06040: formate + retinoate <=> formate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes a monocarboxylate transporter specific for taurine, facilitating its efflux or influx across the plasma membrane. It is involved in the pH- and sodium-independent transport of taurine. However, the provided reaction, which involves formate and retinoate, does not pertain to taurine transport. Therefore, the gene's function and the reaction involving formate and retinoate are unrelated.	No
ENSG00000141526	O15427	MAR06040: formate + retinoate <=> formate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate. It is involved in the transport of these substrates across the cell membrane. The reactions catalyzed by this gene involve L-lactate and H+ ions or pyruvate and H+ ions, which are not related to the reaction provided (formate + retinoate <=> formate + retinoate). Therefore, based on the annotation of the gene, the gene and the reaction are not related.	No
ENSG00000118596	O60669	MAR06040: formate + retinoate <=> formate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000118596 encodes for a proton-coupled monocarboxylate symporter, which is involved in the transport of monocarboxylates like L-lactate, pyruvate, and ketone bodies across the plasma membrane. However, the reaction provided involves formate and retinoate, which are not substrates of the symporter detailed in the gene¡¯s catalytic activities. Therefore, the gene is not related to the reaction involving formate and retinoate.	No
ENSG00000100156	O95907	MAR06041: (R)-3-hydroxybutanoate + formate <=> (R)-3-hydroxybutanoate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000100156 encodes for a probable retinal pigment epithelium-specific proton-coupled L-lactate transporter, which facilitates the transport of lactate and hydrogen ions (H+). However, the reaction provided involves the exchange of (R)-3-hydroxybutanoate and formate, which does not involve lactate or hydrogen ions, making the gene unrelated to the reaction.	No
ENSG00000108932	O15403	MAR06041: (R)-3-hydroxybutanoate + formate <=> (R)-3-hydroxybutanoate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 is described as a monocarboxylate transporter selective for taurine, involved in the facilitative efflux or influx of taurine across the plasma membrane. The catalytic activity listed for this gene specifically involves the transport of taurine. In contrast, the reaction provided ((R)-3-hydroxybutanoate + formate <=> (R)-3-hydroxybutanoate + formate) does not involve taurine. Therefore, the gene and the reaction are not related.	No
ENSG00000108932	O15403	MAR06042: L-lactate + propanoate <=> L-lactate + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 is involved in the transport of taurine across the plasma membrane, as indicated by its function and catalytic activity description, which specifically mentions taurine transport. The reaction provided, however, involves the exchange between L-lactate and propanoate, which does not involve taurine. Therefore, the gene's function is not related to the chemical reaction mentioned.	No
ENSG00000108932	O15403	MAR06043: butyrate + propanoate <=> butyrate + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes for a monocarboxylate transporter selective for taurine, facilitating its efflux or influx across the plasma membrane, which is pH- and sodium-independent and operates under specific conditions where taurine is concentrated. However, the provided reaction involves butyrate and propanoate, which are not related to taurine. Thus, the gene's function does not overlap with the reaction involving butyrate and propanoate.	No
ENSG00000141526	O15427	MAR06043: butyrate + propanoate <=> butyrate + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a proton-dependent transporter responsible for the transport of monocarboxylates such as L-lactate and pyruvate, facilitating their efflux from glycolytic cells. The catalytic activities involve reactions with L-lactate and pyruvate, as indicated by the provided references and evidence. The reaction given involves butyrate and propanoate, which are not substrates for the transporter associated with this gene. Consequently, the gene does not relate to the specified reaction involving butyrate and propanoate.	No
ENSG00000155380	P53985	MAR06044: propanoate + retinoate <=> propanoate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000155380 encodes a proton-coupled monocarboxylate transporter, involved in the transport of monocarboxylates like lactate, pyruvate, acetate, ketone bodies, 3-hydroxybutyrate, and succinate across the plasma membrane. It plays a role in maintaining intracellular pH and cellular responses to metabolic states. However, the reaction provided involves propanoate and retinoate, which are not substrates associated with the catalytic activities of this gene, indicating no relevance to the annotated function of the gene.	No
ENSG00000108932	O15403	MAR06044: propanoate + retinoate <=> propanoate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. The gene ENSG00000108932 is involved in the transport of taurine across the plasma membrane, which is a process independent of the specific biochemical reaction provided (propanoate + retinoate <=> propanoate + retinoate). The reactions involving taurine transport provided in the gene annotation are not related to the unspecified reaction mentioning propanoate and retinoate.	No
ENSG00000141526	O15427	MAR06044: propanoate + retinoate <=> propanoate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000141526 encodes a proton-dependent transporter involved in the transport of monocarboxylates such as L-lactate and pyruvate. It facilitates the efflux of L-lactate and the transport of pyruvate across cellular membranes. The reactions it catalyzes are specific to lactate and pyruvate transport. However, the provided reaction involves propanoate and retinoate, which are not related to the transporter¡¯s function of monocarboxylate transport. Thus, the gene does not relate to the given reaction.	No
ENSG00000108932	O15403	MAR06045: (R)-3-hydroxybutanoate + propanoate <=> (R)-3-hydroxybutanoate + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes a monocarboxylate transporter selective for taurine, indicating its involvement in the transport of taurine across the plasma membrane. The described catalytic activity supports the movement of taurine, either in or out of the cell. However, the provided reaction involves (R)-3-hydroxybutanoate and propanoate, which are different substrates and not related to taurine transport. Therefore, the gene's function and the reaction are not related.	No
ENSG00000141526	O15427	MAR06045: (R)-3-hydroxybutanoate + propanoate <=> (R)-3-hydroxybutanoate + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate and is involved in their efflux from highly glycolytic cells. The reactions catalyzed by this transporter specifically involve L-lactate and pyruvate as substrates. However, the referenced reaction involves (R)-3-hydroxybutanoate and propanoate, which are not substrates of the gene's encoded transporter. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000141526	O15427	MAR06046: acetoacetate + butyrate <=> acetoacetate + butyrate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a proton-dependent transporter of monocarboxylates, specifically involved in the transport of L-lactate and pyruvate. The documented catalytic activities involve the transport of L-lactate and pyruvate in and out of the cell in a proton-coupled manner. The provided reaction, acetoacetate + butyrate <=> acetoacetate + butyrate, does not involve L-lactate, pyruvate, or proton transport, and therefore, the gene's function is unrelated to this reaction.	No
ENSG00000108932	O15403	MAR06047: (R)-3-hydroxybutanoate + acetoacetate <=> (R)-3-hydroxybutanoate + acetoacetate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 is associated with the transport of taurine across the plasma membrane and does not participate in catalyzing the reaction involving (R)-3-hydroxybutanoate and acetoacetate. The reaction described involves the interconversion of (R)-3-hydroxybutanoate and acetoacetate, which is unrelated to taurine transport. Therefore, the gene ENSG00000108932 and the provided reaction are not related.	No
ENSG00000141526	O15427	MAR06047: (R)-3-hydroxybutanoate + acetoacetate <=> (R)-3-hydroxybutanoate + acetoacetate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The annotated gene ENSG00000141526 encodes a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate, facilitating their transport across the cell membrane. The described reactions involve lactate and pyruvate transport, which is different from the provided reaction of (R)-3-hydroxybutanoate with acetoacetate. Thus, the gene's function does not align with the specific reaction given.	No
ENSG00000108932	O15403	MAR06049: L-lactate + retinoate <=> L-lactate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes a monocarboxylate transporter selective for taurine, mediating the transport of taurine across the plasma membrane. However, the provided reaction involves L-lactate and retinoate, which are not substrates related to the transporter function described for the gene. Therefore, the gene's function does not align with the reaction involving L-lactate and retinoate.	No
ENSG00000108932	O15403	MAR06050: (R)-3-hydroxybutanoate + L-lactate <=> (R)-3-hydroxybutanoate + L-lactate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes for a monocarboxylate transporter selective for taurine and is involved in the transport of taurine across the plasma membrane. The catalytic activity associated with this gene involves the movement of taurine, as described by the reactions: taurine(out) = taurine(in), which is both pH- and sodium-independent. In contrast, the reaction provided involves the interconversion of (R)-3-hydroxybutanoate and L-lactate, which does not involve taurine and is thus unrelated to the function of the gene annotated.	No
ENSG00000141526	O15427	MAR06050: (R)-3-hydroxybutanoate + L-lactate <=> (R)-3-hydroxybutanoate + L-lactate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 functions as a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate. Its annotated catalytic activities involve the transport of (S)-lactate and pyruvate across membranes, facilitated by proton gradients. However, the reaction provided involves (R)-3-hydroxybutanoate and L-lactate, which differs from the substrates associated with the gene's function. Therefore, the gene's transporter role does not align with the reaction involving (R)-3-hydroxybutanoate and L-lactate.	No
ENSG00000155380	P53985	MAR06051: butyrate + retinoate <=> butyrate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000155380 encodes for a bidirectional proton-coupled monocarboxylate transporter involved in the rapid transport of monocarboxylates like lactate, pyruvate, acetate, and ketone bodies. The specific reaction given, "butyrate + retinoate <=> butyrate + retinoate," does not involve any of these substrates or monocarboxylate transport functions. Therefore, based on the gene's characterized activities and the substrates it transports, there is no relation between the gene and the reaction provided.	No
ENSG00000100156	O95907	MAR06051: butyrate + retinoate <=> butyrate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000100156 is involved in the transport of lactate and protons across cellular membranes, specifically in the retinal pigment epithelium. The reaction detailed in the catalytic activity is the exchange of lactate and hydrogen ions. In contrast, the reaction provided involves the interconversion of butyrate and retinoate, which is unrelated to the gene's described function and catalytic activity. Therefore, there is no direct relationship between the gene's function and the provided reaction.	No
ENSG00000108932	O15403	MAR06051: butyrate + retinoate <=> butyrate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes a monocarboxylate transporter that is selective for taurine and facilitates the transport of taurine across the plasma membrane. It does not describe any involvement in reactions involving butyrate and retinoate. Therefore, the annotated function and catalytic activity of this gene do not relate to the reaction butyrate + retinoate <=> butyrate + retinoate.	No
ENSG00000100156	O95907	MAR06052: (R)-3-hydroxybutanoate + butyrate <=> (R)-3-hydroxybutanoate + butyrate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000100156 encodes a protein that functions as a proton-coupled L-lactate transporter, facilitating the transport of lactate and H+ ions out of the retina. The provided reaction involves the exchange of (R)-3-hydroxybutanoate and butyrate, which are not related to the lactate transport function of the gene mentioned. Therefore, the functionality of the gene has no direct connection with the specified reaction.	No
ENSG00000108932	O15403	MAR06052: (R)-3-hydroxybutanoate + butyrate <=> (R)-3-hydroxybutanoate + butyrate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes a monocarboxylate transporter that is selective for taurine and is involved in the facilitative transport of taurine across the plasma membrane. The reactions described for the gene involve the transport of taurine, which is not related to the reaction (R)-3-hydroxybutanoate + butyrate <=> (R)-3-hydroxybutanoate + butyrate, indicating a different substrate and mechanism altogether.	No
ENSG00000118596	O60669	MAR06053: (R)-3-hydroxybutanoate + retinoate <=> (R)-3-hydroxybutanoate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000118596 encodes a proton-coupled monocarboxylate symporter, which transports molecules such as L-lactate, pyruvate, ketone bodies, acetoacetate, beta-hydroxybutyrate, and acetate across the plasma membrane. The provided reaction, (R)-3-hydroxybutanoate + retinoate <=> (R)-3-hydroxybutanoate + retinoate, involves retinoate, a molecule not mentioned in the gene's catalytic activity functions, indicating that the gene is not relevant to the reaction.	No
ENSG00000174640	Q92959	MAR06218: arachidonate + GSH + HCO3- <=> arachidonate + GSH + HCO3-	ENSG00000174640	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000174640 is primarily involved in the transport of prostaglandins and thromboxanes across cell membranes and their subsequent clearance from the circulation. This gene has no annotated function related to the reaction involving arachidonate, GSH, and HCO3-, which is not a substrate or product of the gene's known catalytic activities. Therefore, based on the provided annotation, the gene and the reaction are not related.	No
ENSG00000174640	Q92959	MAR06223: GSH + HCO3- + leukotriene F4 <=> GSH + HCO3- + leukotriene F4	ENSG00000174640	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000174640 is involved in the transport of prostaglandins and thromboxanes across cell membranes and is associated with various physiological functions related to prostaglandin transport and metabolism. The reactions it catalyzes involve the transport of different prostaglandins and thromboxanes, using lactate as a counter-substrate. However, the provided reaction, which involves GSH, HCO3-, and leukotriene F4, is not related to these functions or catalyzed by this gene, indicating no direct relevance.	No
ENSG00000174640	Q92959	MAR06224: GSH + HCO3- + prostaglandin A1 <=> GSH + HCO3- + prostaglandin A1	ENSG00000174640	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000174640 primarily mediates the transport of various prostaglandins and thromboxanes across cell membranes and is involved in processes such as cellular uptake, regulation of extracellular PGE2 concentration, and inorganic anion transport. However, the provided reaction involves glutathione (GSH), bicarbonate (HCO3-), and prostaglandin A1, which do not fall within the functional activities or catalytic activities associated with the gene described. The gene's annotated functions and catalytic activities do not mention the specific interaction with prostaglandin A1 or the involvement of GSH and HCO3-. Therefore, the gene is not relevant to the reaction provided.	Not sure, keep it now.
ENSG00000146477	O75751	MAR06247: prostaglandin F2alpha --> prostaglandin F2alpha	ENSG00000112499 or ENSG00000146477 or ENSG00000174640 or ENSG00000175003	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000146477 codes for an electrogenic voltage-dependent transporter involved in the transport of various organic cations such as bioactive amines, cationic drugs, and xenobiotics. Its catalytic activities include the transport of compounds like noradrenaline, adrenaline, serotonin, dopamine, histamine, tyramine, guanidine, agmatine, spermidine, cyclo(his-pro), and salsolinol across cellular membranes, driven by electrochemical potential. However, the reaction provided involves prostaglandin F2alpha, which is not one of the substrates mentioned in the gene's annotated functions. Thus, the gene does not relate to the given reaction of prostaglandin F2alpha.	No
ENSG00000180773	Q6YBV0	MAR06371: glycine + H+ --> glycine + H+	ENSG00000123643 or ENSG00000180773 or ENSG00000186334 or ENSG00000186335	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000180773 encodes a protein that functions as a uniporter, facilitating the transport of neutral amino acids such as L-tryptophan, L-alanine, and L-proline across membranes. The transport is sodium ions-independent and electroneutral, as supported by the referenced literature (PubMed:21097500). The provided reaction involves glycine and hydrogen ions, which is not among the substrates mentioned (L-tryptophan, L-alanine, L-proline). Hence, the gene's function does not correlate with the provided reaction involving glycine and H+.	No
ENSG00000180773	Q6YBV0	MAR06374: H+ + serine --> H+ + serine	ENSG00000123643 or ENSG00000180773 or ENSG00000186334 or ENSG00000186335	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000180773 mediates the transport of neutral amino acids such as L-tryptophan, L-alanine, and L-proline via facilitated diffusion and its activity is sodium ions-independent and electroneutral. The reactions associated with the gene involve the transport of these specific amino acids in and out of cells. However, the provided reaction involves serine and does not align with the transport functions or specific amino acids associated with the gene ENSG00000180773. Therefore, it is not related to the gene's function or catalytic activities.	No
ENSG00000165349	Q8WY07	MAR06379: homoserine + Na+ --> homoserine + Na+	ENSG00000003989 or ENSG00000139514 or ENSG00000165349	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. Although the gene ENSG00000165349 mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine, and L-ornithine as described in its function and catalytic activity, the provided reaction involving homoserine and Na+ does not match any of the catalytic activities mentioned for the gene. Therefore, the gene and the reaction are unrelated.	No
ENSG00000139514	P30825	MAR06379: homoserine + Na+ --> homoserine + Na+	ENSG00000003989 or ENSG00000139514 or ENSG00000165349	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000139514 is involved in the transport of cationic amino acids (arginine, lysine, ornithine, and homoarginine) across cell membranes in non-hepatic tissues, as evidenced by multiple studies. The reactions it catalyzes specifically involve the transport of these amino acids across the cell membrane. However, the reaction provided (homoserine + Na+ --> homoserine + Na+) does not involve any of these amino acids nor does it pertain to transport activity described for this gene. Therefore, the gene and the reaction are not related.	No
ENSG00000003989	P52569	MAR06379: homoserine + Na+ --> homoserine + Na+	ENSG00000003989 or ENSG00000139514 or ENSG00000165349	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000003989 encodes for a permease involved in the transport of cationic amino acids such as L-arginine, L-lysine, L-ornithine, and L-homoarginine. The catalytic activities specified involve the transport of these amino acids across the membrane. However, the reaction provided involves homoserine and sodium (Na+), which does not align with the substrates and activities described for the gene. Therefore, the gene and the reaction are not related.	No
ENSG00000165349	Q8WY07	MAR06383: H+ + homoserine + Na+ --> H+ + homoserine + Na+	ENSG00000003989 or ENSG00000139514 or ENSG00000165349	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000165349 encodes a uniporter involved in the uptake of cationic L-amino acids such as L-arginine, L-lysine, and L-ornithine. This transport is sodium ions- and pH-independent and mediated by passive diffusion. The catalytic activities mentioned for this gene strictly involve the transport of L-arginine, L-lysine, and L-ornithine. The provided reaction involves homoserine along with sodium ions and protons, which is unrelated to the transport activities of the gene ENSG00000165349, making the gene irrelevant to the reaction.	No
ENSG00000139514	P30825	MAR06383: H+ + homoserine + Na+ --> H+ + homoserine + Na+	ENSG00000003989 or ENSG00000139514 or ENSG00000165349	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000139514 encodes a high-affinity, low capacity permease involved in the transport of cationic amino acids such as arginine, lysine, and ornithine in non-hepatic tissues. The annotations specify its catalytic activities involving the transport of these amino acids across membranes. However, the provided reaction involves the transport of homoserine along with a proton (H+) and sodium ion (Na+), which does not match any of the catalytic activities associated with the gene ENSG00000139514. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000003989	P52569	MAR06383: H+ + homoserine + Na+ --> H+ + homoserine + Na+	ENSG00000003989 or ENSG00000139514 or ENSG00000165349	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000003989 functions as a permease involved in the transport of cationic amino acids such as L-arginine, L-lysine, L-ornithine, and L-homoarginine. It catalyzes the transport of these specific amino acids across the cell membrane. However, the reaction provided describes the movement of homoserine and sodium ions, which are not substrates of the gene ENSG00000003989. Therefore, the gene is not related to the reaction involving homoserine and sodium ions.	No
ENSG00000067113	O14494	MAR06512: FAD <=> FAD	ENSG00000039123 or ENSG00000054148 or ENSG00000063601 or ENSG00000067113 or ENSG00000072756 or ENSG00000087053 or ENSG00000126821 or ENSG00000139505 or ENSG00000141934 or ENSG00000162407 or ENSG00000163082	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000067113 encodes for a phospholipid phosphatase enzyme that catalyzes the dephosphorylation of various lipid phosphate esters. However, the reaction provided involves the molecule FAD, which is unrelated to the substrate specificity and the catalytic activities of the enzyme encoded by this gene. Hence, there is no connection between the gene's function and the FAD-related reaction.	No
ENSG00000072756	Q96Q11	MAR06512: FAD <=> FAD	ENSG00000039123 or ENSG00000054148 or ENSG00000063601 or ENSG00000067113 or ENSG00000072756 or ENSG00000087053 or ENSG00000126821 or ENSG00000139505 or ENSG00000141934 or ENSG00000162407 or ENSG00000163082	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000072756 encodes a nucleotidyltransferase involved in the addition and repair of the 3'-terminal CCA sequence in tRNAs, which is crucial for tRNA processing, repair, and recycling. It uses CTP and ATP as substrates, and its function is described in multiple PubMed articles. The reactions catalyzed by this enzyme involve tRNA precursors or tRNAs with 3' end modifications, whereas the reaction provided (FAD <=> FAD) does not relate to tRNA modification or processing but instead involves the flavin adenine dinucleotide (FAD) molecule. There is no indication that the enzyme encoded by ENSG00000072756 participates in FAD-related reactions.	No
ENSG00000139505	Q9Y217	MAR06512: FAD <=> FAD	ENSG00000039123 or ENSG00000054148 or ENSG00000063601 or ENSG00000067113 or ENSG00000072756 or ENSG00000087053 or ENSG00000126821 or ENSG00000139505 or ENSG00000141934 or ENSG00000162407 or ENSG00000163082	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000139505 encodes a phosphatase that acts on lipids with a phosphoinositol headgroup, specifically dephosphorylating phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. It has no relation to the conversion or interaction with FAD (flavin adenine dinucleotide), which is involved in the provided reaction. Therefore, the gene and the reaction are not related.	No
ENSG00000141934	O43688	MAR06512: FAD <=> FAD	ENSG00000039123 or ENSG00000054148 or ENSG00000063601 or ENSG00000067113 or ENSG00000072756 or ENSG00000087053 or ENSG00000126821 or ENSG00000139505 or ENSG00000141934 or ENSG00000162407 or ENSG00000163082	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141934 encodes a magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of various glycerolipid and sphingolipid phosphate esters. Its specific reactions involve the conversion of multiple phospholipid substrates to their corresponding alcohols and phosphate. However, the provided reaction involves FAD (flavin adenine dinucleotide), which is not a substrate or product of the reactions catalyzed by this phospholipid phosphatase, indicating no direct involvement of the gene in the given reaction.	No
ENSG00000225697	Q9BXS9	MAR06530: chloride + 2.0 sulfate --> chloride + 2.0 sulfate	ENSG00000225697	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000225697 encodes an apical membrane anion-exchanger involved in various anion transport processes, including exchanges involving chloride, bicarbonate, oxalate, formate, and sulfate. However, the provided reaction "chloride + 2.0 sulfate --> chloride + 2.0 sulfate" does not match any of the catalytic activities described for the gene's products. The gene products do not mediate a direct reaction involving the interaction between chloride and sulfate in the specified manner.	Not sure, keep it now.
ENSG00000155380	P53985	MAR07666: biotin + H+ --> biotin + H+	ENSG00000155380	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000155380 encodes a proton-coupled monocarboxylate transporter involved in the transmembrane transport of specific monocarboxylates such as lactate, pyruvate, acetate, acetoacetate, beta-hydroxybutyrate, and succinate, as well as their protonated forms. However, the reaction provided involves biotin and a proton (biotin + H+ --> biotin + H+), which does not involve any of these monocarboxylates or their transport across the membrane. Therefore, the gene is not relevant to the reaction provided.	Not sure, keep it now.
ENSG00000118596	O60669	MAR08364: acetone + H+ --> acetone + H+	ENSG00000118596 or ENSG00000141526 or ENSG00000155380	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000118596 encodes a proton-coupled monocarboxylate symporter, which is involved in the transport of monocarboxylates such as L-lactate, pyruvate, and ketone bodies across the plasma membrane. The reactions catalyzed by this gene product do not include the reaction "acetone + H+ --> acetone + H+" as specified in the provided reaction. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000141526	O15427	MAR08364: acetone + H+ --> acetone + H+	ENSG00000118596 or ENSG00000141526 or ENSG00000155380	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a proton-dependent transporter involved in transporting monocarboxylates such as L-lactate and pyruvate across the cell membrane. The annotated catalytic activities specifically involve the transport of these molecules in and out of cells in exchange for protons. However, the reaction provided, "acetone + H+ --> acetone + H+", does not involve monocarboxylates or the transport processes described. The gene's function and activities are unrelated to this reaction.	No

[hhl-24]

All of these seem fine to me.