GPR curation for Transport reactions (9)

[JHL-452b]

Current behavior:

45 genes are discovered to be uncorrelated with their corresponding reactions in Transport reactions.

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000108932	O15403	MAR06013: 2-hydroxybutyrate + retinoate <=> 2-hydroxybutyrate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 functions as a monocarboxylate transporter selective for taurine across the plasma membrane, and its catalytic activity is specifically related to taurine transport (taurine(out) = taurine(in)). The provided reaction involves 2-hydroxybutyrate and retinoate, which are unrelated to the taurine transport function of the gene. Therefore, the gene and the reaction are not related based on their annotations.	No
ENSG00000141526	O15427	MAR06013: 2-hydroxybutyrate + retinoate <=> 2-hydroxybutyrate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000141526 encodes a proton-dependent transporter of monocarboxylates, specifically L-lactate and pyruvate, facilitating their transport across the cell membrane. The provided reaction involves 2-hydroxybutyrate and retinoate, which are not substrates or products associated with the gene's described function or catalytic activity. Therefore, the gene and the reaction are not related.	No
ENSG00000108932	O15403	MAR06014: AKG + pyruvate <=> AKG + pyruvate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes a monocarboxylate transporter selective for taurine and mediates the transport of taurine across the plasma membrane. The reaction described involves AKG (alpha-ketoglutarate) and pyruvate, which are not related to taurine transport or the function of the gene as specified. Therefore, the gene and the reaction are not related.	No
ENSG00000108932	O15403	MAR06015: acetate + pyruvate <=> acetate + pyruvate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes a monocarboxylate transporter specific for taurine, mediating the transport of taurine across the plasma membrane. The catalytic activity described involves taurine transport, which is independent of sodium and pH. However, the provided reaction involving acetate and pyruvate does not involve taurine or monocarboxylate transport, indicating that there is no connection between the gene and the reaction described.	No
ENSG00000108932	O15403	MAR06016: formate + pyruvate <=> formate + pyruvate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 is annotated to function as a monocarboxylate transporter selective for taurine, facilitating its transport across the plasma membrane. This process is pH- and sodium-independent. However, the reaction provided involves the interconversion of formate and pyruvate, which is unrelated to taurine transport. Therefore, the gene's function has no relevance to the reaction described.	No
ENSG00000108932	O15403	MAR06017: propanoate + pyruvate <=> propanoate + pyruvate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene (ENSG00000108932) codes for a monocarboxylate transporter selective for taurine, facilitating the transport of taurine across the plasma membrane. The mentioned catalytic activity involves taurine transport, which is unrelated to the reaction provided, which involves the interchange between propanoate and pyruvate. Hence, the gene and the reaction are not related.	No
ENSG00000108932	O15403	MAR06018: L-lactate + pyruvate <=> L-lactate + pyruvate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 is associated with the monocarboxylate transporter selective for taurine, involved primarily in the pH- and sodium-independent transport of taurine across the plasma membrane. However, the reaction given involves the interconversion of L-lactate and pyruvate, which is not related to the gene's function of taurine transport. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000108932	O15403	MAR06019: butyrate + pyruvate <=> butyrate + pyruvate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes a monocarboxylate transporter that is selective for taurine, facilitating its efflux or influx across the plasma membrane. The transporter¡¯s activity is specific to taurine, operating independently of pH and sodium and effective in high taurine concentration tissues. The reaction provided involves butyrate and pyruvate, which are not substrates of the taurine transporter. Thus, the gene does not relate to the given reaction.	No
ENSG00000108932	O15403	MAR06021: (R)-3-hydroxybutanoate + pyruvate <=> (R)-3-hydroxybutanoate + pyruvate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. Based on the annotation, the gene ENSG00000108932 encodes for a monocarboxylate transporter selective for taurine. Its function involves mediating the transport of taurine across the plasma membrane, which is pH- and sodium-independent and has specific catalytic activities related to taurine transport. However, the provided reaction involves (R)-3-hydroxybutanoate and pyruvate, which are not related to the transport of taurine. Therefore, the gene and the reaction are not related.	No
ENSG00000100156	O95907	MAR06022: acetate + AKG <=> acetate + AKG	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000100156 is annotated to facilitate the transport of lactate and protons in the retina, specifically involving the reaction (S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out). However, the reaction provided involves acetate and alpha-ketoglutarate (AKG), which is unrelated to the gene's function of lactate and proton transport in the retinal pigment epithelium.	No
ENSG00000141526	O15427	MAR06022: acetate + AKG <=> acetate + AKG	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a proton-dependent transporter involved in the transport of monocarboxylates like L-lactate and pyruvate. It does not participate in the reaction involving acetate and alpha-ketoglutarate (AKG) as described in the provided reaction. The gene's catalytic activities are specific to lactate and pyruvate transport, not the substrates mentioned in the given reaction.	No
ENSG00000141526	O15427	MAR06023: AKG + formate <=> AKG + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000141526 encodes a proton-dependent transporter that mediates the transport of monocarboxylates such as L-lactate and pyruvate, as described by multiple sources. The catalytic activities specified involve the transport of these molecules across cellular membranes, facilitated by proton gradients. In contrast, the provided reaction involves alpha-ketoglutarate (AKG) and formate, which falls outside the scope of the transporter's function as there is no indication that the transporter interacts with or transports these molecules.	No
ENSG00000100156	O95907	MAR06024: AKG + propanoate <=> AKG + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000100156 encodes a probable retinal pigment epithelium proton-coupled L-lactate transporter, which facilitates the transport of lactate and protons out of the retina. The catalytic activity described for this gene involves the transport of (S)-lactate and H(+). However, the reaction provided, which involves AKG and propanoate, does not involve lactate or protons, making the gene unrelated to this reaction.	No
ENSG00000108932	O15403	MAR06024: AKG + propanoate <=> AKG + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes a monocarboxylate transporter specific for taurine transport, while the reaction described involves AKG and propanoate, which are unrelated to taurine. Therefore, the function and catalytic activity of the gene do not relate to the provided reaction.	No
ENSG00000141526	O15427	MAR06025: acetoacetate + AKG <=> acetoacetate + AKG	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate, facilitating their efflux and influx. The reactions described for this gene involve the transport of (S)-lactate and pyruvate across membranes in association with protons. However, the provided reaction (acetoacetate + AKG <=> acetoacetate + AKG) does not involve L-lactate, pyruvate, or proton transport, indicating no relevance between the gene function and the reaction.	No
ENSG00000108932	O15403	MAR06026: AKG + L-lactate <=> AKG + L-lactate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes a monocarboxylate transporter selective for taurine, mediating the influx or efflux of taurine across the plasma membrane, a process that is pH- and sodium-independent. The reaction described (AKG + L-lactate <=> AKG + L-lactate) does not involve taurine and instead refers to the interconversion of alpha-ketoglutarate (AKG) and L-lactate, which is unrelated to the function and catalytic activity of the taurine transporter encoded by this gene.	No
ENSG00000100156	O95907	MAR06027: AKG + butyrate <=> AKG + butyrate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000100156 encodes a protein involved in the transport of L-lactate and H(+) ions, facilitating pH and ion homeostasis in the retina. However, the reaction provided involves the interconversion of alpha-ketoglutarate (AKG) and butyrate, which is unrelated to the transport of L-lactate and H(+) ions. Therefore, there is no connection between the gene's function and the given reaction.	No
ENSG00000118596	O60669	MAR06027: AKG + butyrate <=> AKG + butyrate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. According to the provided text, the gene ENSG00000118596 encodes a proton-coupled monocarboxylate symporter that facilitates the transport of various monocarboxylates (such as L-lactate, pyruvate, and ketone bodies) across the plasma membrane. The described catalytic activities involve the transport of these specific compounds in conjunction with protons (H+). However, the reaction "AKG + butyrate <=> AKG + butyrate" listed does not involve the specified substrates (monocarboxylates) or protons, nor does it describe a transport mechanism across the plasma membrane. Hence, the gene's function does not align with the reaction provided.	No
ENSG00000155380	P53985	MAR06028: AKG + retinoate <=> AKG + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000155380 encodes a bidirectional proton-coupled monocarboxylate transporter (MCT1) that facilitates the transport of monocarboxylates like lactate, pyruvate, acetate, ketone bodies, and succinate across the plasma membrane, playing a role in maintaining intracellular pH and cellular metabolic regulation. The provided reaction, "AKG + retinoate <=> AKG + retinoate," does not involve the transport of monocarboxylates or relate to the proton-coupled transport function described for the gene. Thus, the gene and the reaction are not related.	No
ENSG00000108932	O15403	MAR06028: AKG + retinoate <=> AKG + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes a monocarboxylate transporter selective for taurine, mediating the transport of taurine across the plasma membrane. However, the reaction provided (AKG + retinoate <=> AKG + retinoate) does not involve taurine, indicating no relevance between the gene's function and the specified reaction.	No
ENSG00000141526	O15427	MAR06028: AKG + retinoate <=> AKG + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis: The gene ENSG00000141526 encodes a proton-dependent transporter involved in the transport of monocarboxylates like L-lactate and pyruvate, which has specific catalytic activities related to these substrates. However, the provided reaction involves AKG and retinoate, which are not related to the substrates or transport functions of the gene encoded transporter. Therefore, the gene and the reaction are not related.	No
ENSG00000118596	O60669	MAR06028: AKG + retinoate <=> AKG + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000118596 encodes a proton-coupled monocarboxylate symporter responsible for the transport of monocarboxylates like L-lactate, pyruvate, ketone bodies, acetoacetate, beta-hydroxybutyrate, and acetate across the plasma membrane. The reactions it catalyzes involve the movement of these substrates and protons (H+) across the membrane. The provided reaction, AKG + retinoate <=> AKG + retinoate, does not involve any of the substrates or processes related to this gene's function, indicating no relevance between the gene and the reaction.	No
ENSG00000141526	O15427	MAR06029: (R)-3-hydroxybutanoate + AKG <=> (R)-3-hydroxybutanoate + AKG	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000141526 encodes a proton-dependent transporter involved in the transport of monocarboxylates such as L-lactate and pyruvate. The catalytic activities described for this gene involve the transfer of L-lactate and pyruvate across the membrane, coupled with proton translocation. However, the reaction provided involves the conversion of (R)-3-hydroxybutanoate and AKG, which are not substrates or products mentioned in the gene's annotated functions or catalytic activities. Therefore, the gene and the reaction are not related.	No
ENSG00000100156	O95907	MAR06030: 2-hydroxybutyrate + AKG <=> 2-hydroxybutyrate + AKG	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000100156 functions as a probable retinal pigment epithelium-specific proton-coupled L-lactate transporter, facilitating the transport of lactate and protons. The annotated catalytic activity involves the transport of (S)-lactate and protons across the membrane. However, the provided reaction involves the exchange of 2-hydroxybutyrate and alpha-ketoglutarate (AKG), which is unrelated to the transport of lactate and protons as described for this gene. Therefore, the gene and the reaction are not related.	No
ENSG00000108932	O15403	MAR06030: 2-hydroxybutyrate + AKG <=> 2-hydroxybutyrate + AKG	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes for a monocarboxylate transporter selective for taurine, facilitating the efflux or influx of taurine across the plasma membrane. The reaction provided, involving 2-hydroxybutyrate and alpha-ketoglutarate (AKG), does not involve taurine; hence, the gene associated with taurine transport is not relevant to this reaction.	No
ENSG00000100156	O95907	MAR06031: acetate + formate <=> acetate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000100156 encodes for a protein that functions as a proton-coupled L-lactate transporter, facilitating the transport of lactate and H(+) ions across the retinal pigment epithelium. Its annotated catalytic activity involves the reaction (S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out). However, the provided reaction involves the reversible interconversion of acetate and formate, which does not involve lactate or hydrogen ions, indicating no functional or catalytic relevance between the gene's protein product and the given reaction.	No
ENSG00000108932	O15403	MAR06031: acetate + formate <=> acetate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 is annotated to function as a monocarboxylate transporter selective for taurine, mediating its efflux or influx across the plasma membrane. The provided reaction, "acetate + formate <=> acetate + formate," does not involve taurine and instead relates to the exchange of acetate and formate, which are different substrates from what the gene is responsible for transporting. Therefore, the gene and the reaction are not related.	No
ENSG00000141526	O15427	MAR06031: acetate + formate <=> acetate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes for a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate, facilitating their efflux and influx across the cell membrane. The annotated catalytic activities pertain to the transport of L-lactate and pyruvate, involving proton co-transport. The reaction provided, however, is an interchangeable reaction between acetate and formate, which does not involve the transport or metabolism of L-lactate or pyruvate, nor does it require a proton gradient. Hence, the gene's function does not align with the reaction described.	No
ENSG00000118596	O60669	MAR06031: acetate + formate <=> acetate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000118596 encodes a proton-coupled monocarboxylate symporter that facilitates the transport of various monocarboxylates, such as L-lactate, pyruvate, and ketone bodies across the plasma membrane. However, the reaction provided involves the reversible exchange of acetate and formate, which is not listed among the substrates transported by the symporter according to the functional annotation and catalytic activities described for the gene. Therefore, the gene and the reaction are not related.	No
ENSG00000100156	O95907	MAR06032: acetate + propanoate <=> acetate + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000100156 encodes a probable L-lactate transporter specific to the retinal pigment epithelium, which facilitates the transport of lactate and protons. The catalytic activity described for this gene involves the transport of (S)-lactate and H+ ions across the cell membrane. However, the reaction provided involves acetate and propanoate, which are unrelated to the lactate transport function of the gene. Therefore, the gene and the reaction are not related.	No
ENSG00000108932	O15403	MAR06032: acetate + propanoate <=> acetate + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes a monocarboxylate transporter that is selective for taurine and facilitates its transport across the plasma membrane. This process is pH- and sodium-independent and functions primarily in tissues with high taurine concentration. The gene's associated catalytic activity involves the transport of taurine. However, the reaction presented, "acetate + propanoate <=> acetate + propanoate," does not involve taurine or its transport. Therefore, the gene is not relevant to the given reaction.	No
ENSG00000141526	O15427	MAR06032: acetate + propanoate <=> acetate + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000141526 encodes a proton-dependent transporter involved in the transport of monocarboxylates such as L-lactate and pyruvate. The catalytic activities described for the gene include the transport of (S)-lactate and protons, as well as pyruvate and protons across the membrane. However, the provided reaction involves the interchange of acetate and propanoate, which are not substrates for the transporter encoded by this gene as indicated by the provided annotations and catalytic activities. Therefore, the gene does not participate in the given reaction.	No
ENSG00000108932	O15403	MAR06033: acetate + L-lactate <=> acetate + L-lactate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes a monocarboxylate transporter that is selective for taurine and facilitates its efflux or influx across the plasma membrane. The catalytic activity associated with this gene involves the transport of taurine, not acetate or L-lactate. The reaction in question involves acetate and L-lactate, which is unrelated to the taurine transport function of the gene. Therefore, the gene and the reaction are not related.	No
ENSG00000100156	O95907	MAR06034: acetate + butyrate <=> acetate + butyrate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000100156 encodes a probable retinal pigment epithelium-specific proton-coupled L-lactate transporter, which facilitates the transport of lactate and H+ out of the retina, playing a role in pH and ion homeostasis. The annotated catalytic activity involves the transport of (S)-lactate and H+ across membranes. However, the provided reaction involves acetate and butyrate, which are not related to the function of this gene's encoded protein. Therefore, the gene and the reaction are not related.	No
ENSG00000108932	O15403	MAR06034: acetate + butyrate <=> acetate + butyrate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes a monocarboxylate transporter selective for taurine, facilitating the efflux or influx of taurine across the plasma membrane. However, the provided reaction involves acetate and butyrate, which are different compounds unrelated to taurine transport. Therefore, the function and catalytic activity of the gene do not correspond with the reaction involving acetate and butyrate.	No
ENSG00000141526	O15427	MAR06034: acetate + butyrate <=> acetate + butyrate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000141526 is associated with proton-dependent transport of monocarboxylates such as L-lactate and pyruvate. The described function and catalytic activities involve lactate and pyruvate transport, neither of which are involved in the provided reaction: "acetate + butyrate <=> acetate + butyrate". Therefore, the gene and the provided reaction are not related.	No
ENSG00000155380	P53985	MAR06035: acetate + retinoate <=> acetate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000155380 encodes for a bidirectional proton-coupled monocarboxylate transporter, which is involved in the transport of various monocarboxylates like lactate, pyruvate, acetate, and others across the plasma membrane to maintain intracellular pH. The annotation specifies catalytic activities involving the transport of specific substrates including lactate, pyruvate, acetate, and several ketone bodies. The reaction provided, "acetate + retinoate <=> acetate + retinoate", does not involve the transport of these substrates across the plasma membrane nor does it align with the functional activities of the gene. Therefore, based on the gene annotation, the gene ENSG00000155380 is not related to the given reaction.	No
ENSG00000100156	O95907	MAR06035: acetate + retinoate <=> acetate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000100156 is annotated to function as a probable retinal pigment epithelium-specific proton-coupled L-lactate transporter, which facilitates the transport of lactate and H(+) ions to maintain pH and ion homeostasis in the retina. The catalytic activity involves the transport of (S)-lactate and H(+) across the cellular membrane. However, the reaction provided involves acetate and retinoate, which are not related to the lactate transport function of the gene. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000108932	O15403	MAR06035: acetate + retinoate <=> acetate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes a monocarboxylate transporter selective for taurine, facilitating the transport of taurine across the plasma membrane. The specific reaction mentioned in the annotation involves the transport of taurine, but the provided reaction is "acetate + retinoate <=> acetate + retinoate," which does not involve taurine. Hence, the gene is not connected to this reaction.	No
ENSG00000141526	O15427	MAR06035: acetate + retinoate <=> acetate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes for a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate. The catalytic activities described involve the transportation of L-lactate and pyruvate across membranes, with specific reactions involving these substrates. However, the provided reaction involves acetate and retinoate, which do not align with the substrates or the function of the gene product. Therefore, the gene is not relevant to the acetate and retinoate reaction.	No
ENSG00000100156	O95907	MAR06036: (R)-3-hydroxybutanoate + acetate <=> (R)-3-hydroxybutanoate + acetate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000100156 encodes for a probable retinal pigment epithelium-specific proton-coupled L-lactate transporter, which facilitates the transport of lactate and H+ out of the retina, contributing to pH and ion homeostasis. The catalytic activity of this gene involves the transport of (S)-lactate and H+ across the membrane. However, the provided reaction involves (R)-3-hydroxybutanoate and acetate, which is unrelated to the lactate transport activity described for this gene. Therefore, the gene and the reaction are not related.	No
ENSG00000108932	O15403	MAR06036: (R)-3-hydroxybutanoate + acetate <=> (R)-3-hydroxybutanoate + acetate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes a monocarboxylate transporter selective for taurine, which mediates the transport of taurine across the plasma membrane. However, the reaction provided involves the interconversion of (R)-3-hydroxybutanoate and acetate, which is not related to taurine transport. Therefore, the gene's function does not correlate with the described reaction.	No
ENSG00000141526	O15427	MAR06036: (R)-3-hydroxybutanoate + acetate <=> (R)-3-hydroxybutanoate + acetate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000141526 encodes a proton-dependent transporter of monocarboxylates, specifically involved in the transport of L-lactate and pyruvate. The reactions catalyzed by this gene involve the exchange of L-lactate and hydrogen ions and the transport of pyruvate with hydrogen ions. However, the provided reaction involves (R)-3-hydroxybutanoate and acetate, which are not substrates for the transporter encoded by ENSG00000141526. Therefore, the gene and the reaction are not related.	No
ENSG00000100156	O95907	MAR06037: formate + propanoate <=> formate + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000100156 is annotated to encode a protein that functions as a retinal pigment epithelium-specific proton-coupled L-lactate transporter. Its catalytic activity involves transporting (S)-lactate and H+ across the retina cell membrane. However, the provided reaction involves formate and propanoate, which are unrelated to the lactate transport function of the gene product. Therefore, the gene ENSG00000100156 is not relevant to the formate and propanoate reaction.	No
ENSG00000108932	O15403	MAR06037: formate + propanoate <=> formate + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes a monocarboxylate transporter selective for taurine, facilitating the efflux and influx of taurine across the plasma membrane, which is sodium- and pH-independent. However, the reaction given involves formate and propanoate, which are unrelated to the transport of taurine. Hence, the gene and the reaction are not related.	No

[hhl-24]

All of these seem fine to me.