GPR curation for Transport reactions (5)

[JHL-452b]

Current behavior:

40 genes are discovered to be uncorrelated with their corresponding reactions in Transport reactions.

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000103257	Q01650	MAR05613: alanine + Na+ + valine --> alanine + Na+ + valine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103257 is annotated to function as a sodium-independent amino acid transporter, mediating the uptake and exchange of various amino acids such as phenylalanine, tryptophan, histidine, leucine, isoleucine, valine, and tyrosine, among others. However, the provided reaction involves alanine and valine in the presence of sodium (Na+), which indicates a sodium-dependent transport mechanism. Since the gene¡¯s function specifies sodium-independent transport, it does not align with the reaction's sodium dependence. Therefore, the gene is not related to this reaction.	No
ENSG00000105281	Q15758	MAR05614: alanine + Na+ + threonine --> alanine + Na+ + threonine	ENSG00000103064 or ENSG00000105281 or ENSG00000115902	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000105281 is involved in sodium-coupled antiport of neutral amino acids such as L-glutamine, L-serine, L-threonine, L-asparagine, D-serine, and others. However, the provided reaction is a simple exchange of alanine and threonine with sodium, which does not directly match the specific antiporter functions of the gene, which are more complex and involve specific amino acid exchanges coupled with sodium and sometimes protons. Hence, the gene and the reaction are not related.	Yes, both alanine and threonine are neutral amino acids which can be exchanged by this antiporter.
ENSG00000103064	Q92536	MAR05616: alanine + isoleucine + Na+ --> alanine + isoleucine + Na+	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily in the transport and exchange of various amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, often in a sodium-dependent or independent manner. However, the reaction specified involves the exchange of alanine and isoleucine with sodium ions, which is not among the catalytic activities or functions listed for the gene's protein product. Therefore, the gene is not implicated in the reaction involving alanine and isoleucine.	No
ENSG00000103064	Q92536	MAR05617: glutamine + glycine + Na+ --> glutamine + glycine + Na+	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 functions as an antiporter facilitating the export of cationic amino acids such as L-arginine from cells in exchange for neutral amino acids like L-leucine, L-glutamine, and sodium ions, as well as participating in various other L-arginine exchange reactions. The provided reaction involves the conversion of glutamine and glycine with sodium and does not involve any of the specific transport activities or substrates outlined in the gene's annotated functions and catalytic activities. Therefore, the gene does not relate to the specified reaction.	No
ENSG00000103064	Q92536	MAR05633: alanine + Na+ + serine --> alanine + Na+ + serine	ENSG00000103064 or ENSG00000105281 or ENSG00000115902	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions primarily to exchange cationic and neutral amino acids, specifically involved in the transport of L-arginine with various other amino acids such as L-leucine, L-glutamine, L-lysine, and others, often involving sodium ions. However, the provided reaction involves the exchange of alanine and serine in the presence of sodium ions which is not described in any of the catalytic activities of the gene product. Therefore, the gene's function does not align with the reaction presented.	No
ENSG00000103064	Q92536	MAR05635: methionine + Na+ + serine --> methionine + Na+ + serine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter for cationic and neutral amino acids, such as L-arginine, L-leucine, L-glutamine, and L-lysine, typically in exchange reactions involving sodium ions. However, the reaction given involves methionine, sodium, and serine, which is not a substrate nor a product in the annotated functions and catalytic activities of the gene. Thus, the gene does not participate in or facilitate the provided reaction.	No
ENSG00000103064	Q92536	MAR05637: Na+ + phenylalanine + serine --> Na+ + phenylalanine + serine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, primarily involved in the exchange of cationic amino acids such as L-arginine with neutral amino acids like L-leucine, L-glutamine, and others, along with sodium ions. The annotated catalytic activities include various exchanges involving L-arginine but do not mention an interaction with phenylalanine and serine as stated in the provided reaction. Therefore, the gene's function does not align with the described reaction of Na+ with phenylalanine and serine.	No
ENSG00000103064	Q92536	MAR05638: Na+ + serine + tyrosine --> Na+ + serine + tyrosine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 is involved in the transport of cationic and neutral amino acids, such as L-arginine, L-lysine, L-leucine, L-glutamine, and others, in exchange for one another, often involving sodium ions. However, the reaction provided describes the movement of sodium, serine, and tyrosine without any exchange mechanism or involvement of the specific amino acids associated with the gene ENSG00000103064. Hence, based on the gene's specific transport activities and the substances involved, the gene is not relevant to the provided reaction.	No
ENSG00000103064	Q92536	MAR05641: Na+ + proline + serine --> Na+ + proline + serine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. According to the annotation of the gene ENSG00000103064, it functions mainly as an antiporter that specifically exchanges cationic amino acids like L-arginine with neutral amino acids and sodium ions. The gene's activities involve various amino acids such as L-leucine, L-glutamine, L-lysine, L-histidine, L-cysteine, and L-methionine. However, the reaction provided involves the exchange of Na+ with proline and serine, which are not mentioned as substrates in the gene's annotated functions or catalytic activities. Hence, the gene and the reaction are unrelated.	No
ENSG00000103064	Q92536	MAR05642: asparagine + Na+ + serine --> asparagine + Na+ + serine	ENSG00000103064 or ENSG00000105281	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 functions primarily as an antiporter for cationic and neutral amino acids involving specific exchanges primarily between L-arginine and other amino acids such as L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, often in the presence of sodium ions. The described catalytic activities explicitly involve L-arginine and do not involve asparagine or serine. The reaction provided (asparagine + Na+ + serine --> asparagine + Na+ + serine) does not fit within the known functions or catalytic activities of the gene, which indicates the gene is not related to the described reaction.	No
ENSG00000103064	Q92536	MAR05643: Na+ + serine + valine --> Na+ + serine + valine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 is involved in the exchange of cationic amino acids such as L-arginine with other neutral amino acids (e.g., L-leucine, L-glutamine) and sodium ions. It does not have a known function related to the transportation or interaction of serine and valine as described in the reaction Na+ + serine + valine --> Na+ + serine + valine. Therefore, there is no direct connection between the gene's function and the provided reaction.	No
ENSG00000103064	Q92536	MAR05644: Na+ + serine + threonine --> Na+ + serine + threonine	ENSG00000103064 or ENSG00000105281 or ENSG00000115902	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 is primarily involved in the transport of cationic and neutral amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, and others in exchange with sodium ions, as indicated in the detailed function and catalytic activities. These exchanges are crucial for processes like nitric oxide production, ornithine transport, and glycine betaine transport. In contrast, the reaction Na+ + serine + threonine --> Na+ + serine + threonine does not involve L-arginine or any of the amino acids or ions mentioned in the gene's annotated functions and activities. Hence, the gene ENSG00000103064 is not related to this specific reaction.	No
ENSG00000103064	Q92536	MAR05645: homoserine + Na+ + serine --> homoserine + Na+ + serine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 functions primarily as an antiporter for various amino acids such as L-arginine, L-leucine, L-glutamine, L-lysine, etc., and is involved in their exchange across cellular membranes, often in a sodium-dependent manner. The reaction described (homoserine + Na+ + serine --> homoserine + Na+ + serine) does not involve any of the amino acids or transport activities mentioned in the gene's function. Therefore, the gene's annotated functions and the provided reaction are unrelated.	No
ENSG00000103064	Q92536	MAR05648: alanine + methionine + Na+ --> alanine + methionine + Na+	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily as a transporter of cationic amino acids such as L-arginine, in exchange for neutral amino acids like L-leucine, L-glutamine, and others, often involving sodium ions. The annotated reactions catalyzed by this protein involve exchanges of L-arginine with different amino acids like L-lysine, L-leucine, L-glutamine, etc. In contrast, the provided reaction "alanine + methionine + Na+ --> alanine + methionine + Na+" does not involve L-arginine or any of the amino acids the encoded protein is known to transport. Therefore, the gene and the reaction are not related.	No
ENSG00000103064	Q92536	MAR05652: methionine + Na+ + phenylalanine --> methionine + Na+ + phenylalanine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 is involved in the exchange of L-arginine with various amino acids such as L-lysine, L-leucine, L-glutamine, and others, along with sodium ions, based on multiple PubMed studies. The provided reaction, however, involves the exchange of methionine, sodium, and phenylalanine, which is not mentioned in the annotated catalytic activities associated with this gene. Therefore, the gene is not relevant to the specified reaction.	No
ENSG00000103064	Q92536	MAR05655: leucine + methionine + Na+ --> leucine + methionine + Na+	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter involved in the exchange of L-arginine with other amino acids such as L-leucine, L-glutamine, and L-lysine, along with sodium ions. The annotated catalytic activities of this gene focus on these specific amino acid exchanges. However, the provided reaction (leucine + methionine + Na+ --> leucine + methionine + Na+) does not involve L-arginine or any of the specific amino acid exchanges described for the antiporter activity of this gene. Therefore, based on the gene's known functions and catalytic activities, it is not relevant to the given reaction.	No
ENSG00000103064	Q92536	MAR05656: methionine + Na+ + proline --> methionine + Na+ + proline	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that primarily functions as an antiporter for L-arginine and other amino acids such as L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine in exchange for these amino acids along with sodium ions. However, the provided reaction involves methionine, sodium, and proline, which does not align with the annotated catalytic activities of the gene's protein product. Therefore, the gene is not related to the specified reaction.	No
ENSG00000103064	Q92536	MAR05658: methionine + Na+ + valine --> methionine + Na+ + valine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 is involved in the antiport mechanism, exchanging cationic amino acids like L-arginine with neutral amino acids like L-leucine, L-glutamine, and other specific amino acids, often with the involvement of sodium ions. The provided reaction describes the transport of methionine, Na+, and valine, which is not aligned with the specific substrate specificity (L-arginine exchange with other amino acids) described for the gene ENSG00000103064.	No
ENSG00000103064	Q92536	MAR05660: homoserine + methionine + Na+ --> homoserine + methionine + Na+	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, which primarily exchanges cationic amino acids and participates in nitric oxide synthesis. The annotated catalytic activities involve exchanges of L-arginine with various other amino acids and sodium ions. However, the provided reaction only describes a process involving homoserine, methionine, and sodium, which is not among the reactions facilitated by the protein encoded by this gene. Therefore, the gene's function does not relate to the given reaction.	No
ENSG00000103064	Q92536	MAR05666: methionine + Na+ + tryptophan --> methionine + Na+ + tryptophan	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 primarily functions as a cationic amino acid antiporter involved in the exchange of L-arginine with various amino acids such as L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, both in a sodium-dependent and sodium-independent manner. However, the reaction provided involves the exchange of methionine and tryptophan in the presence of sodium, which is not mentioned in the gene's annotated catalytic activities. Therefore, the gene's functions do not align with the reaction involving methionine and tryptophan.	No
ENSG00000103064	Q92536	MAR05667: Na+ + phenylalanine + tryptophan --> Na+ + phenylalanine + tryptophan	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter for cationic and neutral amino acids, including L-arginine, L-lysine, L-leucine, L-glutamine, and others, often in the presence of sodium ions. The specific catalytic activities described involve the exchange of L-arginine with other amino acids such as L-lysine, L-leucine, and L-glutamine, among others, but do not include phenylalanine and tryptophan. Therefore, the provided reaction involving phenylalanine and tryptophan does not match the described functions and activities of the gene ENSG00000103064.	No
ENSG00000103064	Q92536	MAR05668: Na+ + tryptophan + tyrosine --> Na+ + tryptophan + tyrosine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The provided reaction involves the exchange of Na+, tryptophan, and tyrosine, which are not mentioned as substrates or products in any of the catalytic activities of the gene ENSG00000103064. The gene's function is primarily associated with the transport of L-arginine in exchange with other amino acids such as L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, often in a sodium-dependent manner, but does not involve tryptophan or tyrosine.	No
ENSG00000103064	Q92536	MAR05672: asparagine + Na+ + tryptophan --> asparagine + Na+ + tryptophan	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 functions primarily as an antiporter exchanging L-arginine with various amino acids and sodium ions. The described reactions involve exchanges with L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, but not with asparagine or tryptophan. Therefore, the gene's function does not align with the reaction "asparagine + Na+ + tryptophan --> asparagine + Na+ + tryptophan".	No
ENSG00000103064	Q92536	MAR05674: Na+ + threonine + tryptophan --> Na+ + threonine + tryptophan	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 functions as an antiporter involved in the exchange of cationic and neutral amino acids such as L-arginine, L-leucine, L-glutamine, and others, as well as sodium ions. The specific reactions catalyzed by this gene include exchanges like L-arginine(in) + L-lysine(out) and similar amino acid exchange processes. However, the reaction provided involves Na+, threonine, and tryptophan, which are not within the scope of the catalytic activities listed for the gene ENSG00000103064. Therefore, the gene does not participate in the reaction provided.	No
ENSG00000103064	Q92536	MAR05680: Na+ + phenylalanine + serine --> Na+ + phenylalanine + serine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein involved in the exchange of cationic amino acids like L-arginine with neutral amino acids such as L-leucine, L-glutamine, and others, and operates with sodium ions. None of the described catalytic activities or the transport functions of this gene mention the involvement of phenylalanine and serine with sodium ions, which is the reaction specified in the question. Therefore, the gene and the reaction are not related.	No
ENSG00000103064	Q92536	MAR05681: methionine + Na+ + phenylalanine --> methionine + Na+ + phenylalanine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter for cationic and neutral amino acids, specifically involving exchanges of L-arginine with amino acids like L-lysine, L-leucine, L-glutamine, and others, often in a sodium-dependent manner. However, the provided reaction involves methionine, sodium ions, and phenylalanine without any mention of L-arginine, which is the main substrate for the gene-encoded transporter. Therefore, the gene's function does not match with the reaction of methionine and phenylalanine transport, making it irrelevant to the reaction provided.	No
ENSG00000103064	Q92536	MAR05688: Na+ + phenylalanine + valine --> Na+ + phenylalanine + valine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter involved in the exchange of cationic amino acids like L-arginine with neutral amino acids including L-leucine, L-glutamine, and L-isoleucine, among others, and operates with a stoichiometry of 1:1. The specific catalytic activities of the gene-encoded protein involve reactions that exchange L-arginine with various amino acids and sodium ions. However, the reaction provided involves Na+, phenylalanine, and valine without any involvement of L-arginine or the specific amino acids mentioned in the gene's function. Therefore, the gene ENSG00000103064 is not relevant to the given reaction.	No
ENSG00000103064	Q92536	MAR05689: Na+ + phenylalanine + threonine --> Na+ + phenylalanine + threonine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter for exchanging cationic and neutral amino acids such as L-arginine, L-leucine, L-glutamine, and others, often in conjunction with sodium ions. The specific reactions listed involve exchanges like L-arginine with L-lysine, or L-arginine with L-leucine and Na+. However, the provided reaction, Na+ + phenylalanine + threonine --> Na+ + phenylalanine + threonine, does not involve L-arginine or follow the antiport mechanism described for the gene product. Therefore, the gene is not relevant to this reaction.	No
ENSG00000103064	Q92536	MAR05692: glycine + Na+ + tyrosine --> glycine + Na+ + tyrosine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 functions primarily as an antiporter involved in exchanging cationic amino acids (such as L-arginine) with neutral amino acids (like L-leucine, L-glutamine) and ions (like sodium). The catalytic activities described for the gene do not include reactions involving glycine and tyrosine. Therefore, the gene does not relate to the reaction "glycine + Na+ + tyrosine --> glycine + Na+ + tyrosine".	No
ENSG00000103064	Q92536	MAR05693: alanine + Na+ + tyrosine --> alanine + Na+ + tyrosine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 functions primarily as an antiporter involved in the exchange of L-arginine with other amino acids such as L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, often in the presence of sodium ions. However, the provided reaction "alanine + Na+ + tyrosine --> alanine + Na+ + tyrosine" does not involve L-arginine or any of the amino acids that the gene product exchanges. Therefore, the gene is not relevant to this specific reaction.	No
ENSG00000103064	Q92536	MAR05697: Na+ + tryptophan + tyrosine --> Na+ + tryptophan + tyrosine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions as an antiporter for transporting specific cationic and neutral amino acids such as L-arginine, L-leucine, L-glutamine, and others, in exchange with sodium ions, as well as L-lysine, in a sodium-independent manner. However, the provided reaction involves the transport of Na+, tryptophan, and tyrosine, which is not documented as a function of this gene product. Therefore, the gene and the reaction are not related.	No
ENSG00000103064	Q92536	MAR05700: leucine + Na+ + tyrosine --> leucine + Na+ + tyrosine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein involved in the antiporter mechanism, primarily exchanging cationic amino acids such as L-arginine with neutral amino acids like L-leucine, L-glutamine, isoleucine, and others, with or without the involvement of sodium ions. The catalytic activities described include exchanges predominantly involving L-arginine with various other amino acids and sodium ions. In contrast, the reaction provided, "leucine + Na+ + tyrosine --> leucine + Na+ + tyrosine," does not match the substrates or products associated with the gene's function, indicating they are unrelated.	No
ENSG00000103064	Q92536	MAR05701: Na+ + proline + tyrosine --> Na+ + proline + tyrosine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions mainly as an antiporter, exchanging cationic amino acids like L-arginine with neutral amino acids such as L-leucine, L-glutamine, and others in a sodium-dependent or independent manner. The annotation clearly describes the specific amino acids involved in its catalytic activities, such as L-lysine, L-glutamine, L-leucine, etc. However, the provided reaction involves Na+, proline, and tyrosine, which are not mentioned in the gene's associated catalytic activities. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000103064	Q92536	MAR05703: Na+ + tyrosine + valine --> Na+ + tyrosine + valine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that primarily functions as an antiporter, exchanging L-arginine with other amino acids such as L-leucine, L-glutamine, and L-lysine, among others, often in a sodium-dependent manner. The reactions it catalyzes involve the transport of cationic and neutral amino acids across cell membranes. However, the reaction provided (Na+ + tyrosine + valine --> Na+ + tyrosine + valine) does not involve the transport or exchange of L-arginine or any of the amino acids specifically mentioned in the gene's function. Therefore, the gene and the reaction are not related.	No
ENSG00000103064	Q92536	MAR05704: Na+ + threonine + tyrosine --> Na+ + threonine + tyrosine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, exchanging cationic amino acids like L-arginine with other amino acids, typically in a sodium-dependent manner. However, the provided reaction involves the transport of Na+, threonine, and tyrosine, which does not match any of the catalytic activities associated with the gene described. Thus, the gene does not relate to the given reaction.	No
ENSG00000103064	Q92536	MAR05705: homoserine + Na+ + tyrosine --> homoserine + Na+ + tyrosine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter for various amino acids, specifically exporting L-arginine in exchange for other amino acids such as L-lysine, L-leucine, L-glutamine, and others in a sodium-dependent or independent manner. The reaction specified (homoserine + Na+ + tyrosine --> homoserine + Na+ + tyrosine) does not involve L-arginine or the amino acids that the encoded protein transports, nor does it describe an antiport mechanism. Therefore, the function of the gene is not relevant to the reaction provided.	No
ENSG00000103064	Q92536	MAR05713: cysteine + Na+ + phenylalanine --> cysteine + Na+ + phenylalanine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that primarily facilitates the exchange of L-arginine with various neutral or cationic amino acids (e.g., L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, L-methionine) in association with sodium ions. The specific reactions mentioned involve exchanges with L-arginine. However, the provided reaction involves cysteine, sodium, and phenylalanine, which does not align with the known catalytic activities and specific amino acid exchanges facilitated by the protein encoded by ENSG00000103064. Therefore, this gene is not relevant to the reaction provided.	No
ENSG00000103064	Q92536	MAR05714: cysteine + Na+ + tyrosine --> cysteine + Na+ + tyrosine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The provided gene (ENSG00000103064) functions primarily as an antiporter involved in the exchange of cationic and neutral amino acids like L-arginine, L-leucine, L-glutamine, and L-lysine, as well as sodium ions, as indicated by the various catalytic activities described. The reaction mentioned in the prompt involves the exchange of cysteine, Na+, and tyrosine, which does not align with the substrates or activities associated with this gene. Therefore, the gene is not related to the specific reaction provided.	No
ENSG00000103064	Q92536	MAR05718: cysteine + Na+ + valine --> cysteine + Na+ + valine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes for a protein that functions as an antiporter to transport specific amino acids such as L-arginine, L-leucine, L-glutamine, and others, often in exchange with sodium ions. The described catalytic activities are specific to these amino acids and sodium ion interactions. However, the given reaction (cysteine + Na+ + valine --> cysteine + Na+ + valine) does not involve L-arginine or the neutral amino acids mentioned in the gene¯s function. Therefore, the reaction described does not align with the gene's annotated transport activities.	No
ENSG00000103064	Q92536	MAR05719: cysteine + Na+ + threonine --> cysteine + Na+ + threonine	ENSG00000103064 or ENSG00000105281 or ENSG00000115902 or ENSG00000151012	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 is involved in the transport of L-arginine in exchange with other amino acids like L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine. It operates through an antiporter mechanism, mediating exchanges with sodium ions. The reaction described involves the exchange of cysteine, sodium, and threonine, which are not related to the exchange activities mediated by the gene's product according to the provided functional annotation and catalytic activities. Therefore, the gene is not relevant to the reaction provided.	No

[hhl-24]

All of these seem fine to me.