GPR curation for Transport reactions (3)

[JHL-452b]

Current behavior:

40 genes are discovered to be uncorrelated with their corresponding reactions in Transport reactions.

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000003989	P52569	MAR05091: threonine --> threonine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000130876 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000003989 encodes for a permease involved in the transport of specific cationic amino acids such as L-arginine, L-lysine, L-ornithine, and L-homoarginine across cell membranes. Its function is annotated with catalytic activities facilitating the transport of these specific amino acids in and out of the cell. However, the provided reaction involves threonine, which is not mentioned as a substrate for the permease encoded by ENSG00000003989. Therefore, this gene is not relevant to the threonine-related reaction.	No
ENSG00000165349	Q8WY07	MAR05092: isoleucine <=> isoleucine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165349 functions as a uniporter that specifically mediates the uptake of cationic L-amino acids like L-arginine, L-lysine, and L-ornithine. The catalytic activities listed for this gene involve the transport of these specific amino acids across the membrane. The reaction given, which is the interconversion of isoleucine, is not mediated by the gene according to its annotated function and catalytic activities. Therefore, the gene ENSG00000165349 does not have a relevant role in the isoleucine reaction.	No
ENSG00000139514	P30825	MAR05092: isoleucine <=> isoleucine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000139514 is involved in the high-affinity, low-capacity transport of cationic amino acids such as arginine, lysine, and ornithine in non-hepatic tissues, as well as homoarginine. However, the reaction provided involves isoleucine, which is not a cationic amino acid and is not mentioned within the transport activity of the given gene. Hence, there is no relation between the gene and the isoleucine-related reaction.	No
ENSG00000003989	P52569	MAR05092: isoleucine <=> isoleucine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000003989 encodes a permease involved in the transport of specific cationic amino acids such as L-arginine, L-lysine, L-ornithine, and L-homoarginine, as shown by its various isoforms. The described reactions facilitated by this gene include the transport of these amino acids across membranes. However, the provided reaction involves isoleucine, which is not a substrate mentioned within the gene's functional annotation. Therefore, the gene is not relevant to the isoleucine-related reaction.	No
ENSG00000139514	P30825	MAR05305: alanine + Na+ --> alanine + Na+	ENSG00000003989 or ENSG00000072041 or ENSG00000105281 or ENSG00000111371 or ENSG00000115902 or ENSG00000134294 or ENSG00000139209 or ENSG00000139514 or ENSG00000165349 or ENSG00000174358	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000139514 encodes a high-affinity, low-capacity permease involved in the transport of cationic amino acids like arginine, lysine, and ornithine in non-hepatic tissues, as evidenced by various studies. The described catalytic activities are specific to the transport of L-arginine, L-lysine, L-ornithine, and L-homoarginine. However, the provided reaction involves the transport of alanine along with sodium (Na+), which is not mentioned as a substrate or product in the annotated functions of the gene. Therefore, the gene is not relevant to the alanine and sodium transport reaction.	No
ENSG00000003989	P52569	MAR05305: alanine + Na+ --> alanine + Na+	ENSG00000003989 or ENSG00000072041 or ENSG00000105281 or ENSG00000111371 or ENSG00000115902 or ENSG00000134294 or ENSG00000139209 or ENSG00000139514 or ENSG00000165349 or ENSG00000174358	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000003989 functions as a permease involved in the transport of specific cationic amino acids, such as L-arginine, L-lysine, L-ornithine, and L-homoarginine. The catalytic activities described for this gene involve the transport of these amino acids across membranes. However, the reaction provided, "alanine + Na+ --> alanine + Na+," involves the amino acid alanine and sodium ions, which are not substrates or interactions indicated in the gene's function or catalytic activities according to the provided annotations. Thus, there is no relevant connection between the gene's described functions and the specified reaction.	No
ENSG00000165349	Q8WY07	MAR05315: leucine + Na+ --> leucine + Na+	ENSG00000003989 or ENSG00000072041 or ENSG00000111371 or ENSG00000134294 or ENSG00000139209 or ENSG00000139514 or ENSG00000165349 or ENSG00000168003 or ENSG00000174358	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165349 is involved in the transport of cationic L-amino acids such as L-arginine, L-lysine, and L-ornithine based on passive diffusion and is sodium- and pH-independent. The provided reaction involves leucine and sodium (Na+), which does not align with the specific cationic L-amino acids mediated by the gene ENSG00000165349.	No
ENSG00000139514	P30825	MAR05315: leucine + Na+ --> leucine + Na+	ENSG00000003989 or ENSG00000072041 or ENSG00000111371 or ENSG00000134294 or ENSG00000139209 or ENSG00000139514 or ENSG00000165349 or ENSG00000168003 or ENSG00000174358	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000139514 is involved in the high-affinity, low capacity transport of the cationic amino acids arginine, lysine, ornithine, and homoarginine as indicated by its annotated functions and catalytic activities. However, the given reaction involves leucine transport in association with sodium (Na+), which is not one of the amino acids specified in the gene's documented activities. Therefore, the gene and the provided reaction are not related.	No
ENSG00000003989	P52569	MAR05315: leucine + Na+ --> leucine + Na+	ENSG00000003989 or ENSG00000072041 or ENSG00000111371 or ENSG00000134294 or ENSG00000139209 or ENSG00000139514 or ENSG00000165349 or ENSG00000168003 or ENSG00000174358	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000003989 is annotated to function as a permease involved in the transport of cationic amino acids, specifically L-arginine, L-lysine, L-ornithine, and L-homoarginine, and exhibits catalytic activities for their transport. However, the reaction described (leucine + Na+ --> leucine + Na+) involves the transport of leucine and sodium, which are not substrates of the permease encoded by this gene. Therefore, the gene is not related to the reaction provided.	No
ENSG00000165349	Q8WY07	MAR05319: Na+ + phenylalanine --> Na+ + phenylalanine	ENSG00000003989 or ENSG00000111371 or ENSG00000134294 or ENSG00000139209 or ENSG00000139514 or ENSG00000165349 or ENSG00000174358	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165349 encodes a uniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine, and L-ornithine via passive diffusion, which is sodium ions- and pH-independent. The reaction provided involves the transport of phenylalanine in the presence of sodium ions, which is not the function of the gene mentioned. Therefore, the gene is not relevant to the given reaction.	No
ENSG00000139514	P30825	MAR05319: Na+ + phenylalanine --> Na+ + phenylalanine	ENSG00000003989 or ENSG00000111371 or ENSG00000134294 or ENSG00000139209 or ENSG00000139514 or ENSG00000165349 or ENSG00000174358	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000139514 is involved in the high-affinity, low-capacity transport of cationic amino acids such as arginine, lysine, and ornithine across cellular membranes. The reactions it catalyzes include the transport of L-arginine, L-lysine, L-ornithine, and L-homoarginine, but not phenylalanine. The reaction provided involves the transport of phenylalanine, which is not one of the substrates associated with the gene's annotated function. Hence, the gene and the reaction are not related.	No
ENSG00000003989	P52569	MAR05319: Na+ + phenylalanine --> Na+ + phenylalanine	ENSG00000003989 or ENSG00000111371 or ENSG00000134294 or ENSG00000139209 or ENSG00000139514 or ENSG00000165349 or ENSG00000174358	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENCODES a permease involved in the transport of cationic amino acids such as L-arginine, L-lysine, L-ornithine, and L-homoarginine. It does not transport phenylalanine, making it unrelated to the reaction Na+ + phenylalanine --> Na+ + phenylalanine.	No
ENSG00000174358	Q695T7	MAR05330: glutamate + Na+ --> glutamate + Na+	ENSG00000079215 or ENSG00000105143 or ENSG00000106688 or ENSG00000110436 or ENSG00000162383 or ENSG00000174358 or ENSG00000178537	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000174358 functions as a sodium-dependent transporter responsible for the resorption of neutral amino acids across renal and intestinal epithelial cells. It mediates the transport of several specific amino acids, including L-alanine, L-cysteine, L-glutamine, glycine, L-isoleucine, L-leucine, L-methionine, L-phenylalanine, L-serine, L-tryptophan, L-tyrosine, and L-valine, but does not have any documented catalytic activity for transporting glutamate. The provided reaction involves the transport of glutamate with sodium, for which there is no evidence of involvement of ENSG00000174358 based on the gene's annotation.	No
ENSG00000178537	O43772	MAR05330: glutamate + Na+ --> glutamate + Na+	ENSG00000079215 or ENSG00000105143 or ENSG00000106688 or ENSG00000110436 or ENSG00000162383 or ENSG00000174358 or ENSG00000178537	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000178537 is involved in the transport of acylcarnitines and carnitine across the mitochondrial inner membrane, aiding in mitochondrial fatty acid beta-oxidation. It catalyzes the exchange of various forms of carnitine, including O-acyl-(R)-carnitine and O-acetyl-(R)-carnitine, but does not play a role in the transport of glutamate associated with Na+ ions. The provided reaction involving glutamate and Na+ is not related to the function of this gene.	No
ENSG00000149150	O75387	MAR05441: homoserine <=> homoserine	ENSG00000149150	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149150 mediates the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, L-phenylalanine, and L-methionine through facilitated diffusion and is involved in sodium ions-independent electroneutral transport. However, the reaction provided (homoserine <=> homoserine) involving homoserine does not relate to these activities. The gene's function and its catalyzed reactions do not include or mention homoserine, indicating no relevance to the reaction provided.	Yes, homoserine belongs to neutral amino acids which can be transported by this enzyme.
ENSG00000148942	Q1EHB4	MAR05450: glucose + Na+ --> glucose + Na+	ENSG00000117834 or ENSG00000140675 or ENSG00000148942 or ENSG00000154025 or ENSG00000158865	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000148942 functions as a sodium-dependent solute transporter and catalyzes the transport of monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate, and beta-D-hydroxybutyrate across the plasma membrane. The provided reaction, "glucose + Na+ --> glucose + Na+," involves glucose transport, which is not within the substrates mentioned in the gene's annotated functions and catalytic activities. Therefore, the gene and the reaction are not related.	No
ENSG00000165029	O95477	MAR05528: asparagine + tryptophan <=> asparagine + tryptophan	ENSG00000103257 or ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 encodes a protein that primarily functions as an ATP-dependent translocator of specific phospholipids and cholesterol across membrane leaflets, which is not related to the reaction involving asparagine and tryptophan. The catalytic activities described for the gene involve different substrates and processes (such as phosphatidylcholine, phosphatidylserine, sphingomyelin, and cholesterol), none of which are related to the transformation of asparagine and tryptophan. Therefore, the gene's function does not correspond to the reaction provided.	No
ENSG00000165029	O95477	MAR05529: tryptophan + valine <=> tryptophan + valine	ENSG00000103257 or ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 encodes a protein that catalyzes the translocation of specific phospholipids and cholesterol across membranes using ATP hydrolysis. The provided reaction, tryptophan + valine <=> tryptophan + valine, does not involve phospholipid or cholesterol translocation, nor does it require ATP hydrolysis, which are the primary activities associated with the gene product. Therefore, the gene and the reaction are not related.	No
ENSG00000165029	O95477	MAR05530: threonine + tryptophan <=> threonine + tryptophan	ENSG00000103257 or ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000165029 encodes a protein that catalyzes the translocation of specific phospholipids, such as phosphatidylcholine and phosphatidylserine, as well as sphingomyelin and cholesterol, using ATP hydrolysis. The provided reaction involves an exchange between threonine and tryptophan, which is unrelated to the gene's function in phospholipid and cholesterol transport. Additionally, there is no mention of threonine or tryptophan in the gene¡¯s annotated functions or catalytic activities. Thus, the gene and the reaction are not related.	No
ENSG00000165029	O95477	MAR05531: homoserine + tryptophan <=> homoserine + tryptophan	ENSG00000103257 or ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 involves the translocation of specific phospholipids and cholesterol across membranes, catalyzed by the hydrolysis of ATP. It participates in the formation of nascent high density lipoproteins (HDLs) and prefers phosphatidylcholine and phosphatidylserine as substrates, along with sphingomyelin and cholesterol. The provided reaction, which involves homoserine and tryptophan, does not align with the gene's function or catalytic activities involving phospholipids and cholesterol. Therefore, the gene is not related to the reaction.	No
ENSG00000165029	O95477	MAR05532: isoleucine + tryptophan <=> isoleucine + tryptophan	ENSG00000103257 or ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 encodes a protein involved in the ATP-dependent translocation of specific phospholipids and cholesterol across membranes, aiding the formation of high density lipoproteins (HDLs). The cited catalytic activities describe reactions involving phospholipids, cholesterol, ATP, and related molecules, but none mention a reaction involving isoleucine and tryptophan. The provided reaction "isoleucine + tryptophan <=> isoleucine + tryptophan" does not align with the gene's phospholipid and cholesterol translocation functions. Therefore, the gene is not relevant to the reaction.	No
ENSG00000165029	O95477	MAR05534: cysteine + phenylalanine <=> cysteine + phenylalanine	ENSG00000103257 or ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 codes for a protein involved in the translocation of specific phospholipids and cholesterol across membranes, coupled with ATP hydrolysis. It functions in the formation of high density lipoproteins (HDLs) and preferentially transports phosphatidylcholine, phosphatidylserine, sphingomyelin, and cholesterol. The catalytic activities defined for this gene are specific to these substrates and do not include the reaction where cysteine and phenylalanine interconvert. Therefore, the gene is not relevant to the reaction involving cysteine and phenylalanine.	No
ENSG00000165029	O95477	MAR05535: leucine + phenylalanine <=> leucine + phenylalanine	ENSG00000103257 or ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 is involved in the translocation of specific phospholipids and possibly cholesterol across membranes, coupled with the hydrolysis of ATP. The reactions it catalyzes involve phospholipids such as phosphatidylcholine, phosphatidylserine, and sphingomyelin, as well as cholesterol. In contrast, the provided reaction involves the equilibrium between leucine and phenylalanine, which are amino acids. There is no indication from the gene's function or catalytic activities that it plays any role in amino acid reactions, making it unrelated to the leucine-phenylalanine interchange.	No
ENSG00000165029	O95477	MAR05536: phenylalanine + proline <=> phenylalanine + proline	ENSG00000103257 or ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 codes for a protein that catalyzes the translocation of specific phospholipids and cholesterol across membranes, utilizing ATP hydrolysis. The reactions it catalyzes involve substrates such as phosphatidylcholine, phosphatidylserine, sphingomyelin, and cholesterol, but not amino acids. The provided reaction involves phenylalanine and proline, which are unrelated to the gene's annotated functions involving lipid transport and ATPase activity. Therefore, the gene and the reaction are not related.	No
ENSG00000165029	O95477	MAR05537: asparagine + phenylalanine <=> asparagine + phenylalanine	ENSG00000103257 or ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 is involved in the translocation of specific phospholipids and cholesterol across the membrane coupled to ATP hydrolysis. It has catalytic activities related to phosphatidylcholine, phosphatidylserine, sphingomyelin, and cholesterol transport, as detailed in several referenced studies. However, the reaction provided involves the interconversion of asparagine and phenylalanine, which is not related to the functions and catalytic activities of the gene described in the annotation.	No
ENSG00000165029	O95477	MAR05538: phenylalanine + valine <=> phenylalanine + valine	ENSG00000103257 or ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000165029 encodes for a protein that catalyzes the translocation of specific phospholipids and cholesterol across membranes, utilizing ATP hydrolysis. However, the reaction "phenylalanine + valine <=> phenylalanine + valine" involves amino acids phenylalanine and valine, and does not involve phospholipids, cholesterol, or ATP hydrolysis. Therefore, the gene's function does not relate to this reaction.	No
ENSG00000165029	O95477	MAR05539: phenylalanine + threonine <=> phenylalanine + threonine	ENSG00000103257 or ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000165029 encodes a protein that functions as a transporter of specific phospholipids and cholesterol across cellular membranes, facilitating their movement from the cytoplasmic side to the extracellular or lumenal side, which is coupled with ATP hydrolysis. It is involved in processes such as the formation of high-density lipoproteins (HDLs) by transferring phospholipids to apolipoproteins. The gene exhibits catalytic activity for reactions involving phospholipids and cholesterol, but does not relate to the reaction involving phenylalanine and threonine. Therefore, based on the gene's function and catalytic activities, it is not relevant to the reaction phenylalanine + threonine <=> phenylalanine + threonine.	No
ENSG00000165029	O95477	MAR05541: isoleucine + phenylalanine <=> isoleucine + phenylalanine	ENSG00000103257 or ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The function of the gene ENSG00000165029 is primarily involved in the translocation of specific phospholipids and cholesterol across cell membranes, utilizing ATP hydrolysis as part of its catalytic activity. This gene facilitates the transportation of molecules such as phosphatidylcholine, phosphatidylserine, and sphingomyelin, contributing to the formation of high-density lipoproteins (HDLs). In contrast, the provided reaction describes a simple amino acid equilibrium involving isoleucine and phenylalanine, which is unrelated to the phospholipid and cholesterol transport functions of the gene. Therefore, no direct connection exists between the gene's annotated functions and the isoleucine-phenylalanine reaction.	No
ENSG00000188687	Q9BY07	MAR05547: threonine + tyrosine <=> threonine + tyrosine	ENSG00000103257 or ENSG00000188687	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000188687 encodes a protein that mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, which involves the transport of sodium ions and bicarbonate ions across cell membranes. The reactions associated with this gene involve the movement of hydrogencarbonate (bicarbonate) and sodium ions. However, the reaction provided (threonine + tyrosine <=> threonine + tyrosine) does not involve sodium or bicarbonate ions and is unrelated to sodium bicarbonate cotransport. Therefore, the gene and the reaction are not related.	No
ENSG00000103257	Q01650	MAR05565: proline + threonine <=> proline + threonine	ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The provided gene ENSG00000103257 encodes for a transporter involved in the uptake and exchange of large neutral amino acids, thyroid hormones, and other specific molecules across the cell membrane. However, the reaction mentioned (proline + threonine <=> proline + threonine) does not involve the transport or exchange of the amino acids that the gene's product is known to mediate. Therefore, the gene is not related to the described reaction.	No
ENSG00000103257	Q01650	MAR05566: homoserine + proline <=> homoserine + proline	ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103257 encodes a protein that functions primarily as a sodium-independent, high-affinity transporter involved in the uptake of large neutral amino acids, L-DOPA, thyroid hormones, and nitrosothiols across cell membranes. It is also involved in mTORC1 activation and uptake of toxic methylmercury. The reaction provided (homoserine + proline <=> homoserine + proline) does not involve the transport or exchange of any of these molecules, thus there is no relevance between the gene and the reaction.	No
ENSG00000103064	Q92536	MAR05597: asparagine + glycine + Na+ --> asparagine + glycine + Na+	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 functions primarily as an antiporter for exchanging cationic amino acids like L-arginine with various neutral amino acids and sodium ions. The reactions it catalyzes involve the exchange of L-arginine with other amino acids such as L-lysine, L-leucine, L-glutamine, and others. However, the reaction provided: "asparagine + glycine + Na+ --> asparagine + glycine + Na+" does not involve L-arginine or the specific amino acids mentioned in the gene's annotation. Thus, this gene does not participate in the specified reaction.	No
ENSG00000103257	Q01650	MAR05599: glycine + Na+ + threonine --> glycine + Na+ + threonine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103257 encodes a protein that functions primarily as a transporter for large neutral amino acids and certain thyroid hormones, as well as being involved in L-DOPA transport and activation of mTORC1 signaling. The catalytic activities associated with this gene involve the transport of specific amino acids and thyroid hormones across cell membranes. However, the provided reaction "glycine + Na+ + threonine --> glycine + Na+ + threonine" does not involve the transport of large neutral amino acids or thyroid hormones, nor does it involve L-DOPA transport or mTORC1 signaling activation. Therefore, the activities and functions of the protein encoded by the gene ENSG00000103257 do not match the reaction provided, indicating that the gene is not relevant to this reaction.	No
ENSG00000103064	Q92536	MAR05600: glycine + homoserine + Na+ --> glycine + homoserine + Na+	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter involved in the exchange of cationic and neutral amino acids such as L-arginine, L-leucine, and L-glutamine, among others. The described reactions involve L-arginine exchange with several different amino acids and sodium ions. However, the provided reaction is the conversion of glycine and homoserine in the presence of sodium ions, which does not align with the known catalytic activities of the protein encoded by this gene. Therefore, this gene is not related to the reaction involving glycine and homoserine.	No
ENSG00000103064	Q92536	MAR05604: alanine + Na+ + serine --> alanine + Na+ + serine	ENSG00000103064 or ENSG00000105281 or ENSG00000115902	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions as an antiporter for cationic and neutral amino acids, specifically involving the exchange of L-arginine with other amino acids such as L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, in both sodium-dependent and sodium-independent manners. The provided reaction involves alanine and serine along with sodium ions, which are not substrates or products mentioned in the gene's known catalytic activities. Therefore, based on the gene annotation, the gene ENSG00000103064 is not relevant to the given reaction.	No
ENSG00000103064	Q92536	MAR05605: alanine + methionine + Na+ --> alanine + methionine + Na+	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein functioning primarily in the antiport of cationic and neutral amino acids such as L-arginine, L-leucine, L-glutamine, and others, often involving sodium ions. However, the specified reaction involves alanine and methionine, which are not listed among the substrates transported by the gene's product. The gene's function and catalytic activities do not align with the given reaction.	No
ENSG00000103064	Q92536	MAR05607: alanine + Na+ + phenylalanine --> alanine + Na+ + phenylalanine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that primarily functions as an antiporter for cationic and neutral amino acids such as L-arginine, L-leucine, L-glutamine, and L-lysine, often involving sodium ions. The catalytic activities listed involve specific exchanges between L-arginine and other amino acids. However, the provided reaction involves the exchange of alanine and phenylalanine, which is not mentioned in the gene's annotated functions or catalytic activities. Therefore, the gene ENSG00000103064 is not related to the provided reaction.	No
ENSG00000103064	Q92536	MAR05609: alanine + cysteine + Na+ --> alanine + cysteine + Na+	ENSG00000103064 or ENSG00000105281 or ENSG00000115902	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, which primarily facilitates the exchange of L-arginine with other amino acids such as L-leucine, L-glutamine, L-lysine, and others, often involving sodium ions (Na+). The catalytic activities described for this gene do not include the reaction involving alanine and cysteine with sodium. Therefore, there is no relevance between the gene's annotated functions and the reaction provided.	No
ENSG00000103064	Q92536	MAR05610: alanine + leucine + Na+ --> alanine + leucine + Na+	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein involved in the antiporter mechanism that exchanges cationic and neutral amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, and others, primarily in exchange with sodium ions. The specific reactions listed in the gene's function involve L-arginine and various other amino acids. The provided reaction, "alanine + leucine + Na+ --> alanine + leucine + Na+," does not match any of the catalytic activities described for the gene ENSG00000103064, hence it is not relevant.	No
ENSG00000103064	Q92536	MAR05613: alanine + Na+ + valine --> alanine + Na+ + valine	ENSG00000103064 or ENSG00000103257	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter for cationic and neutral amino acids such as L-arginine, L-lysine, L-leucine, and others, in the presence or absence of sodium ions. The described catalytic activities and reactions involve various amino acids like L-arginine, L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine. However, the provided reaction involves alanine, valine, and sodium, which are not substrates documented in the gene's described functions and activities. Therefore, the gene and the reaction are not related.	No

[hhl-24]

keep ENSG00000149150(Uniport that mediates the transport of neutral amino acids) for MAR05441: homoserine <=> homoserine.

[JHL-452b]

Agree to keep ENSG00000149150 for MAR05441.