GPR curation for Transport reactions (1)

[JHL-452b]

Current behavior:

39 genes are discovered to be uncorrelated with their corresponding reactions in Transport reactions.

Gene	UniProtID	Reaction	GPR	Correlation
ENSG00000140284	O14975	MAR01665: cholate --> cholate	ENSG00000083807 or ENSG00000140284	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000140284 primarily functions in the transportation and ATP-dependent formation of various fatty acyl-CoA derivatives, including long-chain fatty acids and very long-chain fatty acids. It does not play a role in the conversion of cholate, as indicated by the reaction description "cholate --> cholate" which does not align with any of the catalytic activities or physiological functions of the gene described.	No
ENSG00000143554	Q5K4L6	MAR00155: butyrate <=> butyrate	ENSG00000113396 or ENSG00000121769 or ENSG00000130304 or ENSG00000135218 or ENSG00000143554 or ENSG00000145384 or ENSG00000163586 or ENSG00000164434 or ENSG00000164687 or ENSG00000167114 or ENSG00000170231 or ENSG00000170323 or ENSG00000197416 or ENSG00000205186	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000143554 encodes an enzyme that mainly functions as an acyl-CoA ligase, catalyzing the ATP-dependent formation of fatty acyl-CoA using long-chain fatty acids (LCFA) and very-long-chain fatty acids (VLCFA) as substrates. The provided reaction, which involves the interconversion of butyrate (a short-chain fatty acid), is not within the specific substrate range (LCFA or VLCFA) handled by the enzyme associated with this gene. Therefore, the gene does not relate to the given reaction involving butyrate.	No
ENSG00000107159	Q16790	MAR00190: ATP + H2O + lauric acid --> ADP + H+ + lauric acid + Pi	ENSG00000074410 or ENSG00000104267 or ENSG00000107159 or ENSG00000118298 or ENSG00000131686 or ENSG00000133742 or ENSG00000159593 or ENSG00000164879 or ENSG00000165029 or ENSG00000166747 or ENSG00000167434 or ENSG00000168748 or ENSG00000169239 or ENSG00000174990 or ENSG00000185015	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000107159 encodes a protein involved in the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid. The catalytic activity described involves the reaction between hydrogen ions and bicarbonate to form carbon dioxide and water. In contrast, the reaction provided involves ATP, H2O, and lauric acid to produce ADP, H+, lauric acid, and Pi, which is unrelated to the gene's function of converting carbon dioxide and bicarbonate.	No
ENSG00000164879	P07451	MAR00190: ATP + H2O + lauric acid --> ADP + H+ + lauric acid + Pi	ENSG00000074410 or ENSG00000104267 or ENSG00000107159 or ENSG00000118298 or ENSG00000131686 or ENSG00000133742 or ENSG00000159593 or ENSG00000164879 or ENSG00000165029 or ENSG00000166747 or ENSG00000167434 or ENSG00000168748 or ENSG00000169239 or ENSG00000174990 or ENSG00000185015	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000164879 encodes for a protein involved in the reversible hydration of carbon dioxide, with the catalytic activity converting protons and hydrogencarbonate to CO2 and H2O. This specific reaction is distinctly different from the reaction provided (ATP + H2O + lauric acid --> ADP + H+ + lauric acid + Pi). Therefore, based on its known function and catalytic activity, the gene is not relevant to the given reaction.	No
ENSG00000074410	O43570	MAR00190: ATP + H2O + lauric acid --> ADP + H+ + lauric acid + Pi	ENSG00000074410 or ENSG00000104267 or ENSG00000107159 or ENSG00000118298 or ENSG00000131686 or ENSG00000133742 or ENSG00000159593 or ENSG00000164879 or ENSG00000165029 or ENSG00000166747 or ENSG00000167434 or ENSG00000168748 or ENSG00000169239 or ENSG00000174990 or ENSG00000185015	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000074410 encodes an enzyme that catalyzes the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3-) and a proton (H+), which is described by the reaction CO2 + H2O = H(+) + hydrogencarbonate. In contrast, the reaction provided involves the hydrolysis of ATP to ADP, H+, and Pi in the presence of lauric acid. These reactions involve different substrates and products, indicating that the gene ENSG00000074410 is not relevant to the provided reaction.	No
ENSG00000133742	P00915	MAR00190: ATP + H2O + lauric acid --> ADP + H+ + lauric acid + Pi	ENSG00000074410 or ENSG00000104267 or ENSG00000107159 or ENSG00000118298 or ENSG00000131686 or ENSG00000133742 or ENSG00000159593 or ENSG00000164879 or ENSG00000165029 or ENSG00000166747 or ENSG00000167434 or ENSG00000168748 or ENSG00000169239 or ENSG00000174990 or ENSG00000185015	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000133742 encodes a protein that catalyzes the reversible hydration of carbon dioxide and the hydration of cyanamide to urea. The specific reactions it catalyzes are the conversion of hydrogencarbonate to CO2 and H2O, and the conversion of urea to cyanamide and H2O. However, the reaction provided involves the hydrolysis of ATP with lauric acid to produce ADP, H+, lauric acid, and Pi, which is not listed among the catalytic activities of the protein encoded by this gene. Therefore, the gene is not related to the reaction provided.	No
ENSG00000168748	P43166	MAR00190: ATP + H2O + lauric acid --> ADP + H+ + lauric acid + Pi	ENSG00000074410 or ENSG00000104267 or ENSG00000107159 or ENSG00000118298 or ENSG00000131686 or ENSG00000133742 or ENSG00000159593 or ENSG00000164879 or ENSG00000165029 or ENSG00000166747 or ENSG00000167434 or ENSG00000168748 or ENSG00000169239 or ENSG00000174990 or ENSG00000185015	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000168748 encodes for an enzyme that catalyzes the reversible hydration of carbon dioxide. This reaction involves the conversion of H(+) and hydrogencarbonate to CO2 and H2O. However, the provided reaction involves the conversion of ATP, H2O, and lauric acid into ADP, H+, lauric acid, and Pi, which is a different process that does not involve the hydration of carbon dioxide. Therefore, the gene is not relevant to the provided reaction.	No
ENSG00000185015	Q8N1Q1	MAR00190: ATP + H2O + lauric acid --> ADP + H+ + lauric acid + Pi	ENSG00000074410 or ENSG00000104267 or ENSG00000107159 or ENSG00000118298 or ENSG00000131686 or ENSG00000133742 or ENSG00000159593 or ENSG00000164879 or ENSG00000165029 or ENSG00000166747 or ENSG00000167434 or ENSG00000168748 or ENSG00000169239 or ENSG00000174990 or ENSG00000185015	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000185015 codes for an enzyme that catalyzes the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3-), following the reaction H(+) + hydrogencarbonate = CO2 + H2O. However, the provided reaction involves the conversion of ATP, H2O, and lauric acid to ADP, H+, lauric acid, and Pi (phosphate), which is a different biochemical process not related to the function of the enzyme coded by the gene ENSG00000185015. Therefore, the gene is not relevant to the given reaction.	No
ENSG00000113396	Q9Y2P4	MAR00191: tridecylic acid --> tridecylic acid	ENSG00000113396 or ENSG00000121769 or ENSG00000130304 or ENSG00000135218 or ENSG00000143554 or ENSG00000145384 or ENSG00000163586 or ENSG00000164434 or ENSG00000164687 or ENSG00000167114 or ENSG00000170231 or ENSG00000170323 or ENSG00000197416 or ENSG00000205186	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000113396 is involved in mediating the import of long-chain and very-long-chain fatty acids into cells and catalyzes their conversion to fatty acyl-CoA derivatives. The specific reactions it facilitates include the transport and activation of fatty acids and their conversion into fatty acyl-CoA using ATP. However, the provided reaction "tridecylic acid ¡ú tridecylic acid" does not fit within the scope of the gene's annotated functions, as this reaction merely refers to the conversion of tridecylic acid without any mention of transport or acyl-CoA formation, which are the primary functions of the gene in question.	No Yes
ENSG00000165029	O95477	MAR00295: ATP + cis-gondoic acid + H2O --> ADP + cis-gondoic acid + H+ + Pi	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 is involved in the translocation of specific phospholipids and cholesterol across membranes, coupled to the hydrolysis of ATP. The annotated catalytic activities include the translocation of phosphatidylcholine, phosphatidylserine, sphingomyelin, and cholesterol. The provided reaction, however, involves ATP, cis-gondoic acid, H2O, ADP, H+, and Pi, which are not mentioned as substrates or products in the gene's catalytic activities. Thus, the gene is not related to the reaction provided.	No
ENSG00000165029	O95477	MAR00311: ATP + H2O + heneicosanoic acid --> ADP + H+ + heneicosanoic acid + Pi	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000165029 encodes a protein that catalyzes the translocation of specific phospholipids and cholesterol across membranes, coupled to ATP hydrolysis. The provided reaction involves ATP, H2O, and heneicosanoic acid, which results in ADP, H+, heneicosanoic acid, and Pi. This reaction does not involve phospholipids or cholesterol translocation and does not match any of the catalytic activities described for the gene, indicating they are not related.	No
ENSG00000165029	O95477	MAR00317: ATP + behenic acid + H2O --> ADP + behenic acid + H+ + Pi	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000165029 encodes a protein that catalyzes the translocation of specific phospholipids and cholesterol across cell membranes, coupled with ATP hydrolysis. The reactions described for this gene include the translocation of phosphatidylcholine, phosphatidylserine, sphingomyelin, and cholesterol. In contrast, the provided reaction involves ATP, behenic acid, water, ADP, behenic acid, proton, and phosphate, which does not align with any phospholipid or cholesterol translocation activity described for the gene. Therefore, based on the gene's function and the reactions it catalyzes, it is not relevant to the provided reaction.	No
ENSG00000165029	O95477	MAR00335: ATP + H2O + lignocerate --> ADP + H+ + lignocerate + Pi	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 encodes a protein that catalyzes the translocation of specific phospholipids such as phosphatidylcholine, phosphatidylserine, sphingomyelin, and cholesterol across membranes using ATP hydrolysis. The provided reaction, ATP + H2O + lignocerate --> ADP + H+ + lignocerate + Pi, involves a fatty acid (lignocerate) and does not fit with the annotated activities of the gene, which focuses on phospholipid and cholesterol transport mechanisms rather than lignocerate translocation.	No
ENSG00000165029	O95477	MAR00355: ATP + H2O + stearidonic acid --> ADP + H+ + Pi + stearidonic acid	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 encodes a protein that catalyzes the translocation of specific phospholipids and cholesterol across membranes, coupled with ATP hydrolysis, specifically transporting phosphatidylcholine, phosphatidylserine, sphingomyelin, and cholesterol. The provided reaction involves ATP and stearidonic acid, which are not substrates or products associated with the catalytic activities of the protein encoded by this gene. Therefore, the gene and the reaction are not related.	No
ENSG00000165029	O95477	MAR00375: (6Z,9Z,12Z,15Z,18Z,21Z)-THA + ATP + H2O --> (6Z,9Z,12Z,15Z,18Z,21Z)-THA + ADP + H+ + Pi	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000165029 encodes for a protein that catalyzes the translocation of specific phospholipids and cholesterol across the membrane using ATP hydrolysis. The reactions it participates in involve ATP, H2O, and phospholipids or cholesterol, resulting in the transport of these molecules between different sides of the membrane and the conversion of ATP to ADP and phosphate. The provided reaction involves (6Z,9Z,12Z,15Z,18Z,21Z)-THA, which is not mentioned as a substrate or product in any of the reactions catalyzed by the protein encoded by ENSG00000165029, indicating no relevant connection between the gene and the reaction.	No
ENSG00000165029	O95477	MAR00391: 10,13,16,19-docosatetraenoic acid + ATP + H2O --> 10,13,16,19-docosatetraenoic acid + ADP + H+ + Pi	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000165029 encodes for a protein that catalyzes the translocation of specific phospholipids and cholesterol across cellular membranes, specifically involving the hydrolysis of ATP to transport molecules like phosphatidylcholine, phosphatidylserine, and sphingomyelin. The reaction provided involves the conversion of 10,13,16,19-docosatetraenoic acid using ATP, which does not align with the annotated functions of the gene related to phospholipid and cholesterol transport. Thus, the gene and the reaction are not related.	No
ENSG00000165029	O95477	MAR00415: adrenic acid + ATP + H2O --> ADP + adrenic acid + H+ + Pi	ENSG00000165029	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000165029 encodes a protein that catalyzes the translocation of specific phospholipids and cholesterol across membranes, utilizing ATP hydrolysis. The catalytic activities annotated for this gene include the translocation of phosphatidylcholine, phosphatidylserine, sphingomyelin, and cholesterol. However, the reaction described in the query involves the conversion of adrenic acid with ATP and water to ADP, adrenic acid, H+, and phosphate, which does not match any of the described functions or catalytic activities of the gene. Thus, the gene is not relevant to the provided reaction.	No
ENSG00000021488	P82251	MAR01901: glutathionyl-leukotriene C4 + HCO3- + serotonin <=> glutathionyl-leukotriene C4 + HCO3- + serotonin	ENSG00000021488 or ENSG00000084453 or ENSG00000111700	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. According to the annotation, gene ENSG00000021488 encodes a protein that mediates the exchange of cationic and neutral amino acids, such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The provided reaction involves glutathionyl-leukotriene C4, HCO3-, and serotonin, which are not mentioned in the functional or catalytic activities of the gene's encoded protein. Therefore, there is no evidence linking this gene to the reaction involving these substrates.	No
ENSG00000021488	P82251	MAR01903: HCO3- + serotonin + S-glutathionyl-ethacrynic acid <=> HCO3- + serotonin + S-glutathionyl-ethacrynic acid	ENSG00000021488 or ENSG00000084453 or ENSG00000111700	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes for a transporter protein that is involved in the exchange of cationic and neutral amino acids, such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, and L-cystine. The described reactions in the gene annotation specifically involve amino acids exchange, driven by concentration gradients. In contrast, the provided reaction involves the interaction between HCO3-, serotonin, and S-glutathionyl-ethacrynic acid, which does not pertain to the amino acid exchange activity described for the gene product. Therefore, the gene's function and the described reaction are unrelated.	No
ENSG00000021488	P82251	MAR01905: acetylcholine + HCO3- + S-glutathionyl-2-4-dinitrobenzene <=> acetylcholine + HCO3- + S-glutathionyl-2-4-dinitrobenzene	ENSG00000021488 or ENSG00000084453 or ENSG00000111700	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes a protein that functions as a transporter for cationic and neutral amino acids across cell membranes, specifically mediating the exchange of L-arginine with other amino acids like L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The provided reaction involves acetylcholine, HCO3-, and S-glutathionyl-2-4-dinitrobenzene, which are not substrates or products involved with the described transporter functions of the gene. Thus, the gene and the reaction are not related.	No
ENSG00000021488	P82251	MAR01906: acetylcholine + HCO3- + S-glutathionyl-ethacrynic acid <=> acetylcholine + HCO3- + S-glutathionyl-ethacrynic acid	ENSG00000021488 or ENSG00000084453 or ENSG00000111700	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 codes for a protein that associates with SLC3A1 to form a transporter complex involved in the exchange of cationic and neutral amino acids, such as L-arginine and L-leucine, with several specific catalytic activities related to amino acid transport. The reaction provided involves acetylcholine, HCO3-, and S-glutathionyl-ethacrynic acid, which are not substrates or products of the amino acid exchange reactions catalyzed by the protein encoded by ENSG00000021488. Hence, there is no relevance between the gene and the provided reaction.	No
ENSG00000021488	P82251	MAR01907: dopamine + glutathionyl-leukotriene C4 + HCO3- <=> dopamine + glutathionyl-leukotriene C4 + HCO3-	ENSG00000021488 or ENSG00000084453 or ENSG00000111700	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 is involved in forming a transporter complex that exchanges cationic and neutral amino acids, as evidenced by its catalytic activities involving amino acids such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the provided reaction involves dopamine, glutathionyl-leukotriene C4, and HCO3-, which are not substrates or products associated with the gene's transporter function. Therefore, there is no connection between the gene's annotated function and the specified reaction.	No
ENSG00000021488	P82251	MAR01908: dopamine + HCO3- + S-glutathionyl-2-4-dinitrobenzene <=> dopamine + HCO3- + S-glutathionyl-2-4-dinitrobenzene	ENSG00000021488 or ENSG00000084453 or ENSG00000111700	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 is involved in the transport of amino acids, specifically mediating the electrogenic exchange between cationic amino acids and neutral amino acids. Its catalytic activities include various exchanges of L-arginine with other amino acids such as L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the reaction provided involves dopamine, HCO3-, and S-glutathionyl-2-4-dinitrobenzene, which do not relate to the amino acid exchanges or the transport functions attributed to the gene ENSG00000021488. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000147606	Q8TE54	MAR01914: HCO3- + sulfate --> HCO3- + sulfate	ENSG00000091138 or ENSG00000112053 or ENSG00000145217 or ENSG00000147606 or ENSG00000155850 or ENSG00000174502 or ENSG00000181045	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000147606 encodes a protein that functions as an anion channel mediating the transport of various ions including chloride, sulfate, oxalate, iodide, bromide, nitrate, thiocyanate, and gluconate. The reaction specified, HCO3- + sulfate --> HCO3- + sulfate, involves bicarbonate and sulfate ions in a manner that suggests there is no net movement or change, which does not match any of the specific catalytic activities linked to the gene. The enzyme's described functions do not include any reaction that involves both bicarbonate and sulfate together in this manner.	No
ENSG00000091138	P40879	MAR01914: HCO3- + sulfate --> HCO3- + sulfate	ENSG00000091138 or ENSG00000112053 or ENSG00000145217 or ENSG00000147606 or ENSG00000155850 or ENSG00000174502 or ENSG00000181045	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000091138 mediates a chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1, specifically involving the transport of chloride and bicarbonate ions across the intestinal epithelia and playing a role in chloride and bicarbonate homeostasis. However, the provided reaction involves the interaction between bicarbonate (HCO3-) and sulfate, which is unrelated to the chloride-bicarbonate exchange function of the gene. Therefore, the gene ENSG00000091138 does not pertain to the described reaction.	No
ENSG00000136856	Q9NY64	MAR04858: galactose <=> galactose	ENSG00000059804 or ENSG00000117394 or ENSG00000136856 or ENSG00000163581 or ENSG00000197496	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000136856 is described as mediating the transport of glucose, fructose, dehydroascorbate, and trehalose, as well as facilitating hepatic influx of dietary trehalose. However, the reaction provided involves the transport of galactose, a different hexose sugar. Since the gene's known catalytic activities do not include transport of galactose, it is not related to the reaction mentioned.	No
ENSG00000125454	Q9HC21	MAR04933: AKG + Na+ --> AKG + Na+	ENSG00000125454	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter involved in the uptake of thiamine diphosphate and its exchange with thiamine phosphate within mitochondria. The provided reaction, "AKG + Na+ --> AKG + Na+," does not involve thiamine diphosphate or thiamine phosphate and is unrelated to the function or catalytic activity of the gene specified.	No
ENSG00000141526	O15427	MAR04976: acetoacetate + H+ --> acetoacetate + H+	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 is a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate. It facilitates the transport of these molecules across cell membranes. However, the reaction provided involves acetoacetate and H+, which are not substrates for the transporter activity described for this gene. Thus, this gene does not participate in the provided reaction.	No
ENSG00000108932	O15403	MAR05018: (R)-3-hydroxybutanoate + H+ --> (R)-3-hydroxybutanoate + H+	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes a monocarboxylate transporter selective for taurine, facilitating taurine transport across the plasma membrane. However, the reaction provided involves the transport of (R)-3-hydroxybutanoate and H+, which is not related to taurine transportation. Therefore, the gene's function does not align with the reaction described.	No
ENSG00000141526	O15427	MAR05018: (R)-3-hydroxybutanoate + H+ --> (R)-3-hydroxybutanoate + H+	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes for a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate. The reactions catalyzed by this transporter involve the transport of L-lactate and pyruvate across membranes in association with protons. However, the provided reaction involves (R)-3-hydroxybutanoate, which is not mentioned as a substrate for the transporter encoded by this gene. Therefore, the gene is not relevant to the reaction provided.	Yes, (R)-3-hydroxybutanoate is a monocarboxylate
ENSG00000142583	P22732	MAR05029: glucose <=> glucose	ENSG00000059804 or ENSG00000109667 or ENSG00000117394 or ENSG00000133460 or ENSG00000136856 or ENSG00000142583 or ENSG00000146411 or ENSG00000160326 or ENSG00000163581 or ENSG00000173262 or ENSG00000181856 or ENSG00000197241 or ENSG00000197496	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000142583 encodes a fructose transporter that specifically facilitates the transport of fructose across cell membranes and has very low activity with other monosaccharides, such as glucose. The reaction provided, glucose <=> glucose, does not involve fructose and therefore does not correlate with the specific function of the gene product, which is primarily involved in fructose transport and metabolism.	Yes, glucose belongs to monosaccharide and the enzyme coded by this gene has low activity with monosaccharides
ENSG00000149150	O75387	MAR05070: histidine <=> histidine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149150 is involved in the sodium ions-independent facilitated diffusion of neutral amino acids such as L-leucine, L-isoleucine, L-valine, L-phenylalanine, and L-methionine, as indicated by multiple referenced catalytic activities. There is no evidence in the provided annotation that this gene mediates the transport of histidine, which is the reaction specified (histidine <=> histidine). Hence, there is no functional relationship between the gene and the histidine reaction.	No
ENSG00000003989	P52569	MAR05070: histidine <=> histidine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000003989 functions as a permease involved in the transport of cationic amino acids such as L-arginine, L-lysine, L-ornithine, and L-homoarginine. However, the reaction provided involves histidine, which is not one of the substrates mentioned in the gene's function or catalytic activities. Therefore, the gene does not relate to the histidine reaction.	Yes, histidine belongs to cationic amino acids which can be transported by this permease.
ENSG00000165349	Q8WY07	MAR05073: methionine --> methionine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000165349 is involved in the uptake and transport of cationic L-amino acids such as L-arginine, L-lysine, and L-ornithine. The reactions catalyzed by this gene specifically involve the exchange of these amino acids across the membrane. However, the provided reaction involves methionine, which is not a substrate associated with the function of this gene as per the given annotations. Therefore, the gene and the reaction are not related.	No
ENSG00000155465	Q9UM01	MAR05073: methionine --> methionine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000155465 is involved in the transport of amino acids, specifically functioning as an antiporter for cationic and neutral amino acids along with sodium ions. The catalytic activities described involve the exchange of L-arginine, L-leucine, L-lysine, and L-ornithine. However, the reaction in question involves methionine conversion without specifying any transport mechanism or involvement of the described cationic and neutral amino acids. Therefore, based on the provided annotations, the gene does not relate to the methionine reaction.	No
ENSG00000139514	P30825	MAR05073: methionine --> methionine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000139514 encodes a high-affinity, low capacity permease that facilitates the transport of cationic amino acids such as arginine, lysine, and ornithine across membranes in non-hepatic tissues. The gene's annotated catalytic activities include the transport of L-arginine, L-lysine, L-ornithine, and L-homoarginine. However, the reaction provided involves methionine, which is not included in the gene's recognized substrates. Thus, the gene's function and catalytic activities do not relate to the methionine reaction.	No
ENSG00000003989	P52569	MAR05073: methionine --> methionine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000003989 encodes a protein that functions as a permease involved in the transport of cationic amino acids such as L-arginine, L-lysine, L-ornithine, and L-homoarginine. Its catalytic activities are related to the transport of these specific amino acids across cellular membranes. However, the reaction provided, which involves methionine, is not one of the reactions catalyzed or facilitated by the protein encoded by this gene. Therefore, the gene does not have any relevance to the methionine reaction provided.	No
ENSG00000149150	O75387	MAR05074: tyrosine <=> tyrosine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000112394 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149150 is involved in the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, L-phenylalanine, and others. It functions as a uniporter that facilitates the diffusion of these amino acids across the cell membrane. However, the reaction provided involves the reversible transformation of tyrosine (tyrosine <=> tyrosine), which is not listed among the catalytic activities associated with this gene. Therefore, the transport activity of the gene does not align with the reaction involving tyrosine, making the gene irrelevant to the specified reaction.	No Yes
ENSG00000003989	P52569	MAR05074: tyrosine <=> tyrosine	(ENSG00000092068 and ENSG00000168003) or ENSG00000003989 or ENSG00000103257 or ENSG00000112394 or ENSG00000123643 or ENSG00000139514 or ENSG00000149150 or ENSG00000155465 or ENSG00000165349 or ENSG00000167703	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000003989 encodes a permease involved in the transport of cationic amino acids such as L-arginine, L-lysine, L-ornithine, and L-homoarginine. The documented catalytic activities specifically involve the transport of these amino acids in and out of cells. The reaction provided, which involves the conversion of tyrosine to tyrosine, does not align with the functions and activities attributed to the gene, as it is not involved in the transport or conversion of tyrosine. Hence, there is no relevance between the gene and the provided reaction.	No

[hhl-24]

keep ENSG00000113396(Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane) for MAR00191: tridecylic acid --> tridecylic acid.
keep ENSG00000003989(Functions as a permease involved in the transport of the cationic amino acids) for MAR05070: histidine <=> histidine.
keep ENSG00000149150(Uniport that mediates the transport of neutral amino acids) for MAR05074: tyrosine <=> tyrosine.

[JHL-452b]

keep ENSG00000113396(Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane) for MAR00191: tridecylic acid --> tridecylic acid.

I used to think the LCFA are fatty acids with the number of carbon atoms between 14 and 24. But the number of carbon atoms for tridecylic acid is 13. So I agreed with AI's assessment. Whatever, all of them are fatty acids and I agree to keep ENSG00000113396 for MAR00191.

keep ENSG00000003989(Functions as a permease involved in the transport of the cationic amino acids) for MAR05070: histidine <=> histidine.
keep ENSG00000149150(Uniport that mediates the transport of neutral amino acids) for MAR05074: tyrosine <=> tyrosine.

Agree to keep this two items, sorry for ignoring this two items in the previous check.