diff --git a/model/Human-GEM.yml b/model/Human-GEM.yml
index 034fb88c..bf6a70de 100644
--- a/model/Human-GEM.yml
+++ b/model/Human-GEM.yml
@@ -150543,7 +150543,7 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000104331 or ENSG00000133731 or ENSG00000141401"
+      - gene_reaction_rule: "ENSG00000133731 or ENSG00000141401"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.25"
@@ -150617,7 +150617,7 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000003987 or ENSG00000054148 or ENSG00000063601 or ENSG00000087053 or ENSG00000102043 or ENSG00000111077 or ENSG00000111696 or ENSG00000112367 or ENSG00000125458 or ENSG00000126821 or ENSG00000137770 or ENSG00000139304 or ENSG00000139505 or ENSG00000144048 or ENSG00000163082 or ENSG00000163719 or ENSG00000165458 or ENSG00000165688 or ENSG00000198825 or ENSG00000198881 or ENSG00000205309 or ENSG00000205808 or ENSG00000211456 or ENSG00000213920"
+      - gene_reaction_rule: "ENSG00000003987 or ENSG00000063601 or ENSG00000087053 or ENSG00000102043 or ENSG00000111077 or ENSG00000111696 or ENSG00000112367 or ENSG00000126821 or ENSG00000137770 or ENSG00000139304 or ENSG00000139505 or ENSG00000144048 or ENSG00000163719 or ENSG00000165458 or ENSG00000165688 or ENSG00000198825 or ENSG00000198881 or ENSG00000205808 or ENSG00000211456 or ENSG00000213920"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.-"
@@ -150654,7 +150654,7 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000003987 or ENSG00000054148 or ENSG00000063601 or ENSG00000087053 or ENSG00000102043 or ENSG00000111077 or ENSG00000111696 or ENSG00000112367 or ENSG00000125458 or ENSG00000126821 or ENSG00000137770 or ENSG00000139304 or ENSG00000139505 or ENSG00000144048 or ENSG00000163082 or ENSG00000163719 or ENSG00000165458 or ENSG00000165688 or ENSG00000198825 or ENSG00000205309 or ENSG00000205808 or ENSG00000211456 or ENSG00000213920"
+      - gene_reaction_rule: "ENSG00000063601 or ENSG00000087053 or ENSG00000102043 or ENSG00000111077 or ENSG00000111696 or ENSG00000112367 or ENSG00000137770 or ENSG00000139304 or ENSG00000139505 or ENSG00000165458 or ENSG00000165688 or ENSG00000198825 or ENSG00000211456"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.-"
@@ -150838,7 +150838,7 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000003987 or ENSG00000054148 or ENSG00000063601 or ENSG00000087053 or ENSG00000102043 or ENSG00000111077 or ENSG00000111696 or ENSG00000112367 or ENSG00000125458 or ENSG00000126821 or ENSG00000137770 or ENSG00000139304 or ENSG00000139505 or ENSG00000144048 or ENSG00000163082 or ENSG00000163719 or ENSG00000165458 or ENSG00000165688 or ENSG00000198825 or ENSG00000198881 or ENSG00000205309 or ENSG00000205808 or ENSG00000211456 or ENSG00000213920"
+      - gene_reaction_rule: "ENSG00000003987 or ENSG00000087053 or ENSG00000102043 or ENSG00000111077 or ENSG00000111696 or ENSG00000112367 or ENSG00000137770 or ENSG00000139304 or ENSG00000139505 or ENSG00000165458 or ENSG00000198825 or ENSG00000198881 or ENSG00000205808 or ENSG00000211456 or ENSG00000213920"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.-"
@@ -150929,7 +150929,7 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000104331 or ENSG00000133731 or ENSG00000141401"
+      - gene_reaction_rule: "ENSG00000133731 or ENSG00000141401"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.25"
@@ -151095,7 +151095,7 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000104331 or ENSG00000133731 or ENSG00000141401"
+      - gene_reaction_rule: "ENSG00000133731 or ENSG00000141401"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.25"
@@ -151373,7 +151373,7 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000003987 or ENSG00000054148 or ENSG00000063601 or ENSG00000087053 or ENSG00000102043 or ENSG00000111077 or ENSG00000111696 or ENSG00000112367 or ENSG00000125458 or ENSG00000126821 or ENSG00000137770 or ENSG00000139304 or ENSG00000139505 or ENSG00000144048 or ENSG00000163082 or ENSG00000163719 or ENSG00000165458 or ENSG00000165688 or ENSG00000198825 or ENSG00000205309 or ENSG00000205808 or ENSG00000211456 or ENSG00000213920"
+      - gene_reaction_rule: "ENSG00000003987 or ENSG00000054148 or ENSG00000063601 or ENSG00000087053 or ENSG00000102043 or ENSG00000111077 or ENSG00000111696 or ENSG00000112367 or ENSG00000125458 or ENSG00000137770 or ENSG00000139304 or ENSG00000139505 or ENSG00000163719 or ENSG00000165458 or ENSG00000165688 or ENSG00000198825 or ENSG00000205309 or ENSG00000205808 or ENSG00000211456 or ENSG00000213920"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "3.1.3.-"
@@ -151411,7 +151411,7 @@
           - MAM02735c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000107242 or ENSG00000143398 or ENSG00000167103 or ENSG00000186111"
+      - gene_reaction_rule: "ENSG00000143398 or ENSG00000167103 or ENSG00000186111"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "2.7.1.68"
@@ -151725,7 +151725,7 @@
           - MAM02734n: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000107242 or ENSG00000143398 or ENSG00000167103 or ENSG00000186111"
+      - gene_reaction_rule: "ENSG00000107242 or ENSG00000143398 or ENSG00000167103"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: ""