From e54c1aff382a9603498cf02164f9b09173df6223 Mon Sep 17 00:00:00 2001
From: haowang-bioinfo <haowang.bioinfo@gmail.com>
Date: Sun, 1 Oct 2023 21:52:28 +0200
Subject: [PATCH] chore: new version

---
 code/masterScriptFruitflyGEM.m |    2 +-
 model/Fruitfly-GEM.mat         |  Bin 673255 -> 669696 bytes
 model/Fruitfly-GEM.xml         | 5958 +++++++-------------------------
 model/Fruitfly-GEM.yml         | 3472 ++++---------------
 model/dependencies.txt         |    2 +-
 model/metabolites.tsv          |  185 +-
 model/reactions.tsv            |  300 +-
 7 files changed, 2031 insertions(+), 7888 deletions(-)

diff --git a/code/masterScriptFruitflyGEM.m b/code/masterScriptFruitflyGEM.m
index 8ecd867..870835f 100644
--- a/code/masterScriptFruitflyGEM.m
+++ b/code/masterScriptFruitflyGEM.m
@@ -28,7 +28,7 @@
 
 %% Generate Fruitfly-GEM
 [fruitflyGEM, speciesSpecNetwork, gapfillNetwork]=updateAnimalGEM(...
-    fruitflyOrthologPairs,rxnsToAdd,metsToAdd,'Fruitfly-GEM',false);
+    fruitflyOrthologPairs,rxnsToAdd,metsToAdd,'Fruitfly-GEM',true);
 
 
 %% Update annotations
diff --git a/model/Fruitfly-GEM.mat b/model/Fruitfly-GEM.mat
index 676c064721a89525cdb84ed470479061f7101a52..0caec5024c9b9c77b1e4ddbbc838cb0ae6957757 100644
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diff --git a/model/Fruitfly-GEM.xml b/model/Fruitfly-GEM.xml
index da869d4..f5adb79 100644
--- a/model/Fruitfly-GEM.xml
+++ b/model/Fruitfly-GEM.xml
@@ -13,10 +13,10 @@
             <rdf:Bag/>
           </dcterms:creator>
           <dcterms:created rdf:parseType="Resource">
-            <dcterms:W3CDTF>2023-08-16T16:25:05Z</dcterms:W3CDTF>
+            <dcterms:W3CDTF>2023-10-01T21:44:47Z</dcterms:W3CDTF>
           </dcterms:created>
           <dcterms:modified rdf:parseType="Resource">
-            <dcterms:W3CDTF>2023-08-16T16:25:05Z</dcterms:W3CDTF>
+            <dcterms:W3CDTF>2023-10-01T21:44:47Z</dcterms:W3CDTF>
           </dcterms:modified>
           <bqbiol:is>
             <rdf:Bag>
@@ -1294,23 +1294,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM00029c" sboTerm="SBO:0000247" id="MAM00029c" name="(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoic acid" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C20H29O3">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM00029c">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:81563"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA03070025"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM33782"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/16061126"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE7090"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM00030c" sboTerm="SBO:0000247" id="MAM00030c" name="(1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C20H18O3">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -1467,24 +1450,6 @@
           </rdf:RDF>
         </annotation>
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-      <species metaid="MAM00036m" sboTerm="SBO:0000247" id="MAM00036m" name="(24R,25R)3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA" compartment="m" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C48H76N7O21P3S">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM00036m">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:52050"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05450"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM732"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM827"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/46224537"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/HC01459"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM00036x" sboTerm="SBO:0000247" id="MAM00036x" name="(24R,25R)3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA" compartment="x" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C48H76N7O21P3S">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -2005,7 +1970,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:50570"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0006529"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C16218"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050055"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050385"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM954"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/53477850"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/od2coa"/>
@@ -2025,7 +1990,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:50570"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0006529"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C16218"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050055"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050385"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM954"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/53477850"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/od2coa"/>
@@ -2045,7 +2010,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:50570"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0006529"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C16218"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050055"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050385"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM954"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/53477850"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/od2coa"/>
@@ -2415,7 +2380,7 @@
             <rdf:Description rdf:about="#MAM00078x">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/pristcoa"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/CE5125"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:64039"/>
                   <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050064"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM30947"/>
@@ -4697,6 +4662,7 @@
             <rdf:Description rdf:about="#MAM00131c">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/CE4837"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/tettet6coa"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63548"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0006516"/>
@@ -4704,7 +4670,9 @@
                   <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050041"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM1512"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM5945"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM165171"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/53477846"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE4837"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/tettet6coa"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -4739,6 +4707,7 @@
             <rdf:Description rdf:about="#MAM00131r">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/CE4837"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/tettet6coa"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63548"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0006516"/>
@@ -4746,7 +4715,9 @@
                   <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050041"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM1512"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM5945"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM165171"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/53477846"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE4837"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/tettet6coa"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -6149,7 +6120,7 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM00185c" sboTerm="SBO:0000247" id="MAM00185c" name="[apocarboxlase]" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="XH">
+      <species metaid="MAM00185c" sboTerm="SBO:0000247" id="MAM00185c" name="[apocarboxylase]" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="XH">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
             <rdf:Description rdf:about="#MAM00185c">
@@ -8244,6 +8215,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:34306"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C14748"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM22451"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM6760"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/5283157"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/wharachd"/>
                 </rdf:Bag>
@@ -13612,7 +13584,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/ppmi1346p"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C18058"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM34087"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/890"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/96024277"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/ppmi1346p"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -13629,7 +13601,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/ppmi1346p"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C18058"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM34087"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/890"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/96024277"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/ppmi1346p"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -15038,36 +15010,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM00591c" sboTerm="SBO:0000247" id="MAM00591c" name="20-hydroxy-arachidonate" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C20H31O3">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM00591c">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:34306"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C14748"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM6760"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
-      <species metaid="MAM00591e" sboTerm="SBO:0000247" id="MAM00591e" name="20-hydroxy-arachidonate" compartment="e" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C20H31O3">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM00591e">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:34306"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C14748"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM6760"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM00592r" sboTerm="SBO:0000247" id="MAM00592r" name="20-hydroxycholesterol" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C27H46O2">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -15718,27 +15660,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM00616m" sboTerm="SBO:0000247" id="MAM00616m" name="25(R)THCA-CoA" compartment="m" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C48H76N7O20P3S">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM00616m">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/cholcoar"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:37642"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C15613"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMST01010218"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM549"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM90922"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM91096"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/15942889"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/cholcoar"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM00616x" sboTerm="SBO:0000247" id="MAM00616x" name="25(R)THCA-CoA" compartment="x" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C48H76N7O20P3S">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -15796,26 +15717,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM00618m" sboTerm="SBO:0000247" id="MAM00618m" name="25(S)THCA-CoA" compartment="m" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C48H76N7O20P3S">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM00618m">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/cholcoas"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:37643"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C17343"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM1201"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM8131"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/15942888"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/cholcoas"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE5166"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM00618x" sboTerm="SBO:0000247" id="MAM00618x" name="25(S)THCA-CoA" compartment="x" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C48H76N7O20P3S">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -18927,27 +18828,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM00748m" sboTerm="SBO:0000247" id="MAM00748m" name="3alpha,7alpha,12alpha-trihydroxy-5beta-24-oxocholestanoyl-CoA" compartment="m" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C48H74N7O21P3S">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM00748m">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/cholcoaone"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:27379"/>
-                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0006891"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05467"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMST01010216"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM162946"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM873"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/440690"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/cholcoaone"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM00748x" sboTerm="SBO:0000247" id="MAM00748x" name="3alpha,7alpha,12alpha-trihydroxy-5beta-24-oxocholestanoyl-CoA" compartment="x" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C48H74N7O21P3S">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -18969,27 +18849,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM00749m" sboTerm="SBO:0000247" id="MAM00749m" name="3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA" compartment="m" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C48H74N7O20P3S">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM00749m">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/cholcoads"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:27505"/>
-                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0006889"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05460"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMST01010217"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM162945"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM2747"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/5280797"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/cholcoads"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM00749x" sboTerm="SBO:0000247" id="MAM00749x" name="3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA" compartment="x" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C48H74N7O20P3S">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -19352,22 +19211,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM00759c" sboTerm="SBO:0000247" id="MAM00759c" name="3alpha-hydroxy-5alpha-pregnan-20-one" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C21H34O2">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM00759c">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C13712"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMST02030130"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM3494"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/M00759"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM00760c" sboTerm="SBO:0000247" id="MAM00760c" name="3-amino-propanal" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="1" fbc:chemicalFormula="C3H8NO">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -19890,6 +19733,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM1034"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM446"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/45259165"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/3hibutcoa"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/HC01223"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -22075,7 +21919,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:28264"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05267"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050016"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050249"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM706"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/11966162"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/HC01406"/>
@@ -22093,7 +21937,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:28264"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05267"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050016"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050249"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM706"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/11966162"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/HC01406"/>
@@ -22172,7 +22016,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/3ohdcoa"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15491"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05259"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050016"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050250"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM738"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/169621"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/3ohdcoa"/>
@@ -22191,7 +22035,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/3ohdcoa"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15491"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05259"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050016"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050250"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM738"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/169621"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/3ohdcoa"/>
@@ -22286,20 +22130,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM00902c" sboTerm="SBO:0000247" id="MAM00902c" name="3-oxo-tetracosa-9,12,15,18,21-all-cis-pentaenoyl-CoA" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C45H66N7O18P3S">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM00902c">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM164259"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE4820"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM00903c" sboTerm="SBO:0000247" id="MAM00903c" name="3-oxo-tetracosa-9,12,15,18-all-cis-tetraenoyl-CoA" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C45H68N7O18P3S">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -22894,6 +22724,8 @@
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/dmnoncoa"/>
                   <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050034"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM37161"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM6100"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/dmnoncoa"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE4805"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -26483,7 +26315,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/xoltetrol"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17278"/>
-                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0001231"/>
+                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0006264"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05446"/>
                   <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMST04030014"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM163006"/>
@@ -26503,7 +26335,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/xoltetrol"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17278"/>
-                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0001231"/>
+                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0006264"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05446"/>
                   <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMST04030014"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM163006"/>
@@ -29753,7 +29585,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/retinal_cis_9"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM162775"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM2209"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/638015"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/6436082"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/retinal_cis_9"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -31049,90 +30881,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM01268c" sboTerm="SBO:0000247" id="MAM01268c" name="activation-ppara" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C2303H3655N619O695S34R">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM01268c">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/PROTEIN"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/M01268"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
-      <species metaid="MAM01268m" sboTerm="SBO:0000247" id="MAM01268m" name="activation-ppara" compartment="m" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C2303H3655N619O695S34R">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM01268m">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/PROTEIN"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/M01268"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
-      <species metaid="MAM01268n" sboTerm="SBO:0000247" id="MAM01268n" name="activation-ppara" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C2303H3655N619O695S34R">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM01268n">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/PROTEIN"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/M01268"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
-      <species metaid="MAM01268x" sboTerm="SBO:0000247" id="MAM01268x" name="activation-ppara" compartment="x" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C2303H3655N619O695S34R">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM01268x">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/PROTEIN"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/M01268"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
-      <species metaid="MAM01268r" sboTerm="SBO:0000247" id="MAM01268r" name="activation-ppara" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C2303H3655N619O695S34R">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM01268r">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/PROTEIN"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/M01268"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
-      <species metaid="MAM01268e" sboTerm="SBO:0000247" id="MAM01268e" name="activation-ppara" compartment="e" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C2303H3655N619O695S34R">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM01268e">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/PROTEIN"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/M01268"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM01269c" sboTerm="SBO:0000247" id="MAM01269c" name="acyl-CoA-bile-PC pool" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C22H31N7O17P3SR">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -32714,7 +32462,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/gal1p"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17973"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C03384"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00446"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM336"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/123912"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/gal1p"/>
@@ -36150,6 +35898,21 @@
           </rdf:RDF>
         </annotation>
       </species>
+      <species metaid="MAM01422m" sboTerm="SBO:0000247" id="MAM01422m" name="carboxybiotin-carboxyl-carrier" compartment="m" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C17H26N4O5SX">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM01422m">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/cbtnCCP"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C04419"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM5655"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
       <species metaid="MAM01423c" sboTerm="SBO:0000247" id="MAM01423c" name="carnosine" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C9H14N4O3">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -36727,12 +36490,14 @@
             <rdf:Description rdf:about="#MAM01435e">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/C02528"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16755"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0000518"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C02528"/>
                   <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMST04010032"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM1183"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/10133"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/C02528"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/HC00958"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -39147,26 +38912,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM01514m" sboTerm="SBO:0000247" id="MAM01514m" name="choloyl-CoA" compartment="m" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C45H70N7O20P3S">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM01514m">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/cholcoa"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15519"/>
-                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0001374"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01794"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM162468"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM431"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/439573"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/cholcoa"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM01514x" sboTerm="SBO:0000247" id="MAM01514x" name="choloyl-CoA" compartment="x" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C45H70N7O20P3S">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -45441,6 +45186,7 @@
             <rdf:Description rdf:about="#MAM01696c">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/CE2516"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/dlnlcg"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:53486"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0002925"/>
@@ -45449,6 +45195,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM147467"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM5607"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/5280581"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE2516"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/dlnlcg"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -45513,6 +45260,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM5607"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/5280581"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/dlnlcg"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE2516"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -46938,8 +46686,10 @@
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0004058"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05578"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM163363"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM2336"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/114683"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE4888"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/M03162"/>
                   <rdf:li rdf:resource="https://identifiers.org/inchi/InChI=1S/C8H7NO2/c10-7-3-5-1-2-9-6(5)4-8(7)11/h1-4,9-11H"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -47268,7 +47018,7 @@
             <rdf:Description rdf:about="#MAM01746c">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/tag1p__D"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/tag6p__D"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:4251"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01097"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM164716"/>
@@ -49938,20 +49688,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM01816n" sboTerm="SBO:0000247" id="MAM01816n" name="fatty acid-ligands" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="R">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM01816n">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/PROTEIN"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/M01816"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM01819e" sboTerm="SBO:0000247" id="MAM01819e" name="fatty acid-uptake pool" compartment="e" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="CHO2R">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -55044,7 +54780,7 @@
             <rdf:Description rdf:about="#MAM02008c">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/gm1_hs"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/HC02161"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:18216"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C04911"/>
                   <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMSP0601AP00"/>
@@ -55062,7 +54798,7 @@
             <rdf:Description rdf:about="#MAM02008l">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/gm1_hs"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/HC02161"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:18216"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C04911"/>
                   <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMSP0601AP00"/>
@@ -56621,8 +56357,8 @@
             <rdf:Description rdf:about="#MAM02043c">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16094"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00320"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:5587"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05529"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM164836"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM323"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/24478"/>
@@ -63310,7 +63046,7 @@
             <rdf:Description rdf:about="#MAM02328c">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/galgluside_hs"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/digalside_hs"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17950"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0004866"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01290"/>
@@ -63329,7 +63065,7 @@
             <rdf:Description rdf:about="#MAM02328g">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/galgluside_hs"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/digalside_hs"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17950"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0004866"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01290"/>
@@ -63348,7 +63084,7 @@
             <rdf:Description rdf:about="#MAM02328l">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/galgluside_hs"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/digalside_hs"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17950"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0004866"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01290"/>
@@ -63367,7 +63103,7 @@
             <rdf:Description rdf:about="#MAM02328r">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/galgluside_hs"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/digalside_hs"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17950"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0004866"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01290"/>
@@ -63386,7 +63122,7 @@
             <rdf:Description rdf:about="#MAM02328e">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/galgluside_hs"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/digalside_hs"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17950"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0004866"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01290"/>
@@ -71222,9 +70958,9 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/nh4"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16134"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:28938"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0000051"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00014"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01342"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM15"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/222"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/nh4"/>
@@ -71241,9 +70977,9 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/nh4"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16134"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:28938"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0000051"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00014"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01342"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM15"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/222"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/nh4"/>
@@ -73325,7 +73061,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15534"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0001322"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00510"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050055"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050356"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM1848"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM686"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/5280355"/>
@@ -73346,7 +73082,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15534"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0001322"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00510"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050055"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050356"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM1848"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM686"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/5280355"/>
@@ -73367,10 +73103,10 @@
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15534"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0001322"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00510"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050055"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050356"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM1848"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM686"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/5280355"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/5497111"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/odecoa"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -73388,7 +73124,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15534"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0001322"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00510"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050055"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050356"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM1848"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM686"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/5280355"/>
@@ -74253,7 +73989,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/hdcecrn"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM8716"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/11953816"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/129849228"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/hdcecrn"/>
                   <rdf:li rdf:resource="https://identifiers.org/inchi/InChI=1S/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h10-11,21H,5-9,12-20H2,1-4H3/b11-10-/t21-/m1/s1"/>
                 </rdf:Bag>
@@ -74270,7 +74006,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/hdcecrn"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM8716"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/11953816"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/129849228"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/hdcecrn"/>
                   <rdf:li rdf:resource="https://identifiers.org/inchi/InChI=1S/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h10-11,21H,5-9,12-20H2,1-4H3/b11-10-/t21-/m1/s1"/>
                 </rdf:Bag>
@@ -74287,7 +74023,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/hdcecrn"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM8716"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/11953816"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/129849228"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/hdcecrn"/>
                   <rdf:li rdf:resource="https://identifiers.org/inchi/InChI=1S/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h10-11,21H,5-9,12-20H2,1-4H3/b11-10-/t21-/m1/s1"/>
                 </rdf:Bag>
@@ -74388,7 +74124,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00154"/>
                   <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050002"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM88"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/15667"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/644109"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/pmtcoa"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -74408,7 +74144,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00154"/>
                   <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050002"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM88"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/15667"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/644109"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/pmtcoa"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -74428,7 +74164,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00154"/>
                   <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050002"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM88"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/15667"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/644109"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/pmtcoa"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -74448,7 +74184,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00154"/>
                   <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050002"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM88"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/15667"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/644109"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/pmtcoa"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -76521,7 +76257,9 @@
                   <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMPR0104010004"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM165293"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM1774"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM91275"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/26840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/phyt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE2414"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -76563,7 +76301,9 @@
                   <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMPR0104010004"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM165293"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM1774"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM91275"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/26840"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/phyt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE2414"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -77007,45 +76747,6 @@
           </rdf:RDF>
         </annotation>
       </species>
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-        <annotation>
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-            <rdf:Description rdf:about="#MAM02757c">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/M02757"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
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-        </annotation>
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-      <species metaid="MAM02757l" sboTerm="SBO:0000247" id="MAM02757l" name="PPARA" compartment="l" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C2303H3655N619O695S34">
-        <annotation>
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-            <rdf:Description rdf:about="#MAM02757l">
-              <bqbiol:is>
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-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/M02757"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
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-      <species metaid="MAM02757n" sboTerm="SBO:0000247" id="MAM02757n" name="PPARA" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C2303H3655N619O695S34">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM02757n">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/M02757"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM02759c" sboTerm="SBO:0000247" id="MAM02759c" name="PPi" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="HO7P2">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -85390,7 +85091,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0011123"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05279"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM2039"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/53480665"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/5280770"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/C05279"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -85408,7 +85109,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0011123"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05279"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM2039"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/53480665"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/5280770"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/C05279"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -89558,22 +89259,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM03162c" sboTerm="SBO:0000247" id="MAM03162c" name="5,6-dihydroxyindole" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C8H7NO2">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM03162c">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:27404"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05578"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM2336"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/M03162"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM03163c" sboTerm="SBO:0000247" id="MAM03163c" name="indole-5,6-quinone" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C8H5NO2">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -89776,23 +89461,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM03226m" sboTerm="SBO:0000247" id="MAM03226m" name="(S)-3-Hydroxyisobutyryl Coenzyme A" compartment="m" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C25H38N7O18P3S">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM03226m">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/3hibutcoa"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15481"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C04047"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM446"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/3hibutcoa"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM00799c" sboTerm="SBO:0000247" id="MAM00799c" name="3-hydroxypropionyl-CoA" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C24H36N7O18P3S">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -90240,7 +89908,7 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM00185m" sboTerm="SBO:0000247" id="MAM00185m" name="[apocarboxlase]" compartment="m" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="XH">
+      <species metaid="MAM00185m" sboTerm="SBO:0000247" id="MAM00185m" name="[apocarboxylase]" compartment="m" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="XH">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
             <rdf:Description rdf:about="#MAM00185m">
@@ -90657,9 +90325,9 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/nh4"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16134"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:28938"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0000051"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00014"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01342"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM15"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/222"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/nh4"/>
@@ -90881,9 +90549,9 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/nh4"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16134"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:28938"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0000051"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00014"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01342"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM15"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/222"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/nh4"/>
@@ -90954,9 +90622,9 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/nh4"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16134"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:28938"/>
                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0000051"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00014"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01342"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM15"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/222"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/nh4"/>
@@ -91191,21 +90859,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM03554c" sboTerm="SBO:0000247" id="MAM03554c" name="4,8-Dimethylnonanoyl Coenzyme A" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C32H52N7O17P3S">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM03554c">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/dmnoncoa"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM6100"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/dmnoncoa"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM03554m" sboTerm="SBO:0000247" id="MAM03554m" name="4,8-Dimethylnonanoyl Coenzyme A" compartment="m" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C32H52N7O17P3S">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -91543,25 +91196,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM03884e" sboTerm="SBO:0000247" id="MAM03884e" name="Phytanate" compartment="e" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C20H39O2">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM03884e">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/phyt"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16285"/>
-                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0000801"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01607"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM91275"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/26840"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/phyt"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM02808e" sboTerm="SBO:0000247" id="MAM02808e" name="PS-LD pool" compartment="e" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C8H11NO10PR2">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -91741,25 +91375,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM03884c" sboTerm="SBO:0000247" id="MAM03884c" name="Phytanate" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C20H39O2">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM03884c">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/phyt"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16285"/>
-                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0000801"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01607"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM91275"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/26840"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/phyt"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM03791m" sboTerm="SBO:0000247" id="MAM03791m" name="11-Octadecenoyl Coenzyme A" compartment="m" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C39H64N7O17P3S">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -92658,7 +92273,7 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/pristcoa"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:64039"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:77250"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM7699"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/25137904"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/pristcoa"/>
@@ -93424,7 +93039,7 @@
             <rdf:Description rdf:about="#MAM02008e">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/gm1_hs"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/HC02161"/>
                   <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:18216"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C04911"/>
                   <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMSP0601AP00"/>
@@ -93547,44 +93162,6 @@
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-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/C02528"/>
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       <species metaid="MAM00726m" sboTerm="SBO:0000247" id="MAM00726m" name="3,4-dihydroxymandelaldehyde" compartment="m" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C8H8O4">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -93720,25 +93297,6 @@
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         </annotation>
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-      <species metaid="MAM03318e" sboTerm="SBO:0000247" id="MAM03318e" name="Chenodeoxycholate" compartment="e" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C24H39O4">
-        <annotation>
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-            <rdf:Description rdf:about="#MAM03318e">
-              <bqbiol:is>
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-                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0000518"/>
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         <annotation>
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@@ -93890,6 +93448,7 @@
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                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C14748"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM22451"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM6760"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/5283157"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/wharachd"/>
                 </rdf:Bag>
@@ -94078,7 +93637,7 @@
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                   <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0006529"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C16218"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050055"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMFA07050385"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM954"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/53477850"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/od2coa"/>
@@ -97381,25 +96940,6 @@
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         </annotation>
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-        <annotation>
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-                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0006516"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C16171"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM165171"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/53477846"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE4837"/>
-                </rdf:Bag>
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       <species metaid="MAM00681r" sboTerm="SBO:0000247" id="MAM00681r" name="2-trans-9,12,15,18-all-cis-tetracosapentaenoyl-CoA" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C45H68N7O17P3S">
         <annotation>
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@@ -97415,25 +96955,6 @@
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-      <species metaid="MAM03354r" sboTerm="SBO:0000247" id="MAM03354r" name="Tetracosa-9,12,15,18-All-Cis-Tetraenoyl Coenzyme A" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C45H70N7O17P3S">
-        <annotation>
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-            <rdf:Description rdf:about="#MAM03354r">
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-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:63548"/>
-                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0006516"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C16171"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM165171"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/53477846"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE4837"/>
-                </rdf:Bag>
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       <species metaid="MAM00864r" sboTerm="SBO:0000247" id="MAM00864r" name="3-oxo-docosa-7,10,13,16-all-cis-tetraenoyl-CoA" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C43H64N7O18P3S">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -97888,19 +97409,6 @@
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         </annotation>
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-        <annotation>
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-            <rdf:Description rdf:about="#MAM03367m">
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-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE5168"/>
-                </rdf:Bag>
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       <species metaid="MAM03367x" sboTerm="SBO:0000247" id="MAM03367x" name="24(R),25(R)-Varanoyl Coenzyme A" compartment="x" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C48H76N7O21P3S">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -97946,40 +97454,6 @@
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         </annotation>
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-            <rdf:Description rdf:about="#MAM03368m">
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-      <species metaid="MAM03368x" sboTerm="SBO:0000247" id="MAM03368x" name="24-Oxo-25(R)-Trihydroxycoprostanoyl Coenzyme A" compartment="x" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C48H74N7O21P3S">
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       <species metaid="MAM01428e" sboTerm="SBO:0000247" id="MAM01428e" name="CDP-ethanolamine" compartment="e" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C11H19N4O11P2">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -98419,25 +97893,6 @@
           </rdf:RDF>
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-        <annotation>
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-            <rdf:Description rdf:about="#MAM03325c">
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-                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0001527"/>
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-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/C08276"/>
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       <species metaid="MAM03510c" sboTerm="SBO:0000247" id="MAM03510c" name="Methanethiol" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="CH4S">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -98830,25 +98285,6 @@
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-      <species metaid="MAM03332c" sboTerm="SBO:0000247" id="MAM03332c" name="(8Z,11Z,14Z)-Eicosatrienoic Acid" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C20H33O2">
-        <annotation>
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-            <rdf:Description rdf:about="#MAM03332c">
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-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/CE2516"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:53486"/>
-                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0002925"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C03242"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM5607"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/5280581"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE2516"/>
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       <species metaid="MAM02785n" sboTerm="SBO:0000247" id="MAM02785n" name="prostaglandin E1" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C20H33O5">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -99926,22 +99362,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM03540c" sboTerm="SBO:0000247" id="MAM03540c" name="Lauroyl Carnitine" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C19H37NO4">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM03540c">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/ddeccrn"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/168381"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/ddeccrn"/>
-                  <rdf:li rdf:resource="https://identifiers.org/inchi/InChI=1S/C19H37NO4/c1-5-6-7-8-9-10-11-12-13-14-19(23)24-17(15-18(21)22)16-20(2,3)4/h17H,5-16H2,1-4H3/t17-/m1/s1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM00042c" sboTerm="SBO:0000247" id="MAM00042c" name="(2E)-dodecenoyl-CoA" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C33H52N7O17P3S">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -100952,22 +100372,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM03540e" sboTerm="SBO:0000247" id="MAM03540e" name="Lauroyl Carnitine" compartment="e" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C19H37NO4">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM03540e">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/ddeccrn"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/168381"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/ddeccrn"/>
-                  <rdf:li rdf:resource="https://identifiers.org/inchi/InChI=1S/C19H37NO4/c1-5-6-7-8-9-10-11-12-13-14-19(23)24-17(15-18(21)22)16-20(2,3)4/h17H,5-16H2,1-4H3/t17-/m1/s1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM03541e" sboTerm="SBO:0000247" id="MAM03541e" name="Dodecenoyl Carnitine" compartment="e" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C19H35NO4">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -103657,11 +103061,11 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/ptth"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:15525"/>
-                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0001338"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16753"/>
+                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0003426"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C00154"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM1154"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/15667"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/439322"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/ptth"/>
                   <rdf:li rdf:resource="https://identifiers.org/inchi/InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1"/>
                 </rdf:Bag>
@@ -104659,7 +104063,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/hdcecrn"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM8716"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/11953816"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/129849228"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/hdcecrn"/>
                   <rdf:li rdf:resource="https://identifiers.org/inchi/InChI=1S/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h10-11,21H,5-9,12-20H2,1-4H3/b11-10-/t21-/m1/s1"/>
                 </rdf:Bag>
@@ -108112,23 +107516,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM03332e" sboTerm="SBO:0000247" id="MAM03332e" name="(8Z,11Z,14Z)-Eicosatrienoic Acid" compartment="e" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C20H33O2">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM03332e">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:53486"/>
-                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0002925"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C03242"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/5280581"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE2516"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM00378e" sboTerm="SBO:0000247" id="MAM00378e" name="15(S)-HETrE" compartment="e" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C20H33O3">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -109834,20 +109221,6 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM03231c" sboTerm="SBO:0000247" id="MAM03231c" name="3-Hydroxyphenylpropionic Acid (3-Hppa)" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C9H9O3">
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM03231c">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:57277"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/3hppa"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-      </species>
       <species metaid="MAM02622e" sboTerm="SBO:0000247" id="MAM02622e" name="normetanephrine" compartment="e" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="1" fbc:chemicalFormula="C9H14NO3">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -132805,6 +132178,37 @@
           </rdf:RDF>
         </annotation>
       </species>
+      <species metaid="MAM01729e" sboTerm="SBO:0000247" id="MAM01729e" name="dodecanoylcarnitine" compartment="e" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C19H37NO4">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM01729e">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0002250"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM51468"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM588354"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/168381"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/M01729"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="MAM00853c" sboTerm="SBO:0000247" id="MAM00853c" name="3-oxo-all-cis-6,9,12,15,18-tetracosapentaenoyl-CoA" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-4" fbc:chemicalFormula="C45H66N7O18P3S">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM00853c">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM164259"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/CE4820"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
       <species metaid="MAM15003c" sboTerm="SBO:0000247" id="MAM15003c" name="L-Allothreonine" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C4H9NO3">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -133385,19 +132789,21 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM01066r" sboTerm="SBO:0000247" id="MAM01066r" name="5alpha-cholesta-7,24-dien-3beta-ol" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C27H44O">
+      <species metaid="MAM01449r" sboTerm="SBO:0000247" id="MAM01449r" name="cholestenol" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C27H46O">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM01066r">
+            <rdf:Description rdf:about="#MAM01449r">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/chlstol"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16290"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05439"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM162749"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM830"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/chlstol"/>
-                  <rdf:li rdf:resource="https://identifiers.org/inchi/InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/zymstnl"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16608"/>
+                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0006841"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C03845"/>
+                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMST01010096"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM2494"/>
+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/101770"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/zymstnl"/>
+                  <rdf:li rdf:resource="https://identifiers.org/inchi/InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -134497,8 +133903,12 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.3.9"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G6PPer"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G6PP"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_G6PP"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_G6PPer"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00303"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99912"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR195425"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/G6PPer"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/16689"/>
                 </rdf:Bag>
@@ -134861,7 +134271,7 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="GlyS"/>
+            <fbc:geneProductRef fbc:geneProduct="Glys"/>
             <fbc:geneProductRef fbc:geneProduct="Gyg"/>
           </fbc:or>
         </fbc:geneProductAssociation>
@@ -134894,7 +134304,7 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="GlyS"/>
+            <fbc:geneProductRef fbc:geneProduct="Glys"/>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -134959,7 +134369,7 @@
           <speciesReference species="MAM01991c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="GlyP"/>
+          <fbc:geneProductRef fbc:geneProduct="Glyp"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR05399" sboTerm="SBO:0000176" id="MAR05399" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -135052,7 +134462,7 @@
           <speciesReference species="MAM01996c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="GlyP"/>
+          <fbc:geneProductRef fbc:geneProduct="Glyp"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR08568" sboTerm="SBO:0000176" id="MAR08568" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -138634,6 +138044,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:10502673;PMID:3597357;PMID:4062874</p>
           </body>
         </notes>
         <annotation>
@@ -138642,10 +138053,12 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.7"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PPCOAOm"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00924"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103101"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PPCOAOm"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0683"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -138743,9 +138156,9 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="CG17691"/>
+            <fbc:geneProductRef fbc:geneProduct="BckdhA"/>
+            <fbc:geneProductRef fbc:geneProduct="BckdhB"/>
             <fbc:geneProductRef fbc:geneProduct="CG7430"/>
-            <fbc:geneProductRef fbc:geneProduct="CG8199"/>
             <fbc:geneProductRef fbc:geneProduct="Dbct"/>
           </fbc:and>
         </fbc:geneProductAssociation>
@@ -140602,7 +140015,7 @@
           <speciesReference species="MAM02751c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="AdSS"/>
+          <fbc:geneProductRef fbc:geneProduct="Adss"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR04046" sboTerm="SBO:0000176" id="MAR04046" name="Xanthosine-5&apos;-phosphate:L-glutamine amido-ligase (AMP-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -141020,7 +140433,7 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="AdSL"/>
+            <fbc:geneProductRef fbc:geneProduct="Adsl"/>
             <fbc:geneProductRef fbc:geneProduct="gw"/>
           </fbc:or>
         </fbc:geneProductAssociation>
@@ -141894,6 +141307,11 @@
               <fbc:geneProductRef fbc:geneProduct="RnrL"/>
               <fbc:geneProductRef fbc:geneProduct="RnrS"/>
             </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="RnrL"/>
+              <fbc:geneProductRef fbc:geneProduct="RnrS"/>
+              <fbc:geneProductRef fbc:geneProduct="Trx2"/>
+            </fbc:and>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -141936,6 +141354,11 @@
               <fbc:geneProductRef fbc:geneProduct="RnrL"/>
               <fbc:geneProductRef fbc:geneProduct="RnrS"/>
             </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="RnrL"/>
+              <fbc:geneProductRef fbc:geneProduct="RnrS"/>
+              <fbc:geneProductRef fbc:geneProduct="Trx2"/>
+            </fbc:and>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -141977,6 +141400,11 @@
               <fbc:geneProductRef fbc:geneProduct="RnrL"/>
               <fbc:geneProductRef fbc:geneProduct="RnrS"/>
             </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="RnrL"/>
+              <fbc:geneProductRef fbc:geneProduct="RnrS"/>
+              <fbc:geneProductRef fbc:geneProduct="Trx2"/>
+            </fbc:and>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -142020,6 +141448,11 @@
               <fbc:geneProductRef fbc:geneProduct="RnrL"/>
               <fbc:geneProductRef fbc:geneProduct="RnrS"/>
             </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="RnrL"/>
+              <fbc:geneProductRef fbc:geneProduct="RnrS"/>
+              <fbc:geneProductRef fbc:geneProduct="Trx2"/>
+            </fbc:and>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -142061,6 +141494,11 @@
               <fbc:geneProductRef fbc:geneProduct="RnrL"/>
               <fbc:geneProductRef fbc:geneProduct="RnrS"/>
             </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="RnrL"/>
+              <fbc:geneProductRef fbc:geneProduct="RnrS"/>
+              <fbc:geneProductRef fbc:geneProduct="Trx2"/>
+            </fbc:and>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -142102,6 +141540,11 @@
               <fbc:geneProductRef fbc:geneProduct="RnrL"/>
               <fbc:geneProductRef fbc:geneProduct="RnrS"/>
             </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="RnrL"/>
+              <fbc:geneProductRef fbc:geneProduct="RnrS"/>
+              <fbc:geneProductRef fbc:geneProduct="Trx2"/>
+            </fbc:and>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -142145,6 +141588,11 @@
               <fbc:geneProductRef fbc:geneProduct="RnrL"/>
               <fbc:geneProductRef fbc:geneProduct="RnrS"/>
             </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="RnrL"/>
+              <fbc:geneProductRef fbc:geneProduct="RnrS"/>
+              <fbc:geneProductRef fbc:geneProduct="Trx2"/>
+            </fbc:and>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -142188,6 +141636,11 @@
               <fbc:geneProductRef fbc:geneProduct="RnrL"/>
               <fbc:geneProductRef fbc:geneProduct="RnrS"/>
             </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="RnrL"/>
+              <fbc:geneProductRef fbc:geneProduct="RnrS"/>
+              <fbc:geneProductRef fbc:geneProduct="Trx2"/>
+            </fbc:and>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -142364,12 +141817,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03148x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03120x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -142815,7 +142268,7 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="AdSL"/>
+            <fbc:geneProductRef fbc:geneProduct="Adsl"/>
             <fbc:geneProductRef fbc:geneProduct="gw"/>
           </fbc:or>
         </fbc:geneProductAssociation>
@@ -143231,12 +142684,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02159x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03148x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -143856,45 +143309,6 @@
           <fbc:geneProductRef fbc:geneProduct="CG11241"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03931" sboTerm="SBO:0000176" id="MAR03931" name="NADPH:oxidized-thioredoxin oxidoreductase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10462449;PMID:11060283;PMID:15110392</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR03931">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.8.1.9"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TRDR"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02016"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104766"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/TRDR"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/20345"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02555c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02666c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02554c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02990c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Trxr1"/>
-            <fbc:geneProductRef fbc:geneProduct="Trxr2"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR03969" sboTerm="SBO:0000176" id="MAR03969" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -145295,7 +144709,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10542323;PMID:3678231</p>
+            <p>AUTHORS: PMID:10542323;PMID:3678231;PMID:11508704;PMID:5773299</p>
           </body>
         </notes>
         <annotation>
@@ -145308,6 +144722,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04666"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR109033"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96346"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/BUP2"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -145441,6 +144856,11 @@
               <fbc:geneProductRef fbc:geneProduct="RnrL"/>
               <fbc:geneProductRef fbc:geneProduct="RnrS"/>
             </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="RnrL"/>
+              <fbc:geneProductRef fbc:geneProduct="RnrS"/>
+              <fbc:geneProductRef fbc:geneProduct="Trx2"/>
+            </fbc:and>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -145481,6 +144901,11 @@
               <fbc:geneProductRef fbc:geneProduct="RnrL"/>
               <fbc:geneProductRef fbc:geneProduct="RnrS"/>
             </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="RnrL"/>
+              <fbc:geneProductRef fbc:geneProduct="RnrS"/>
+              <fbc:geneProductRef fbc:geneProduct="Trx2"/>
+            </fbc:and>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -145621,6 +145046,11 @@
               <fbc:geneProductRef fbc:geneProduct="RnrL"/>
               <fbc:geneProductRef fbc:geneProduct="RnrS"/>
             </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="RnrL"/>
+              <fbc:geneProductRef fbc:geneProduct="RnrS"/>
+              <fbc:geneProductRef fbc:geneProduct="Trx2"/>
+            </fbc:and>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -145660,6 +145090,11 @@
               <fbc:geneProductRef fbc:geneProduct="RnrL"/>
               <fbc:geneProductRef fbc:geneProduct="RnrS"/>
             </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="RnrL"/>
+              <fbc:geneProductRef fbc:geneProduct="RnrS"/>
+              <fbc:geneProductRef fbc:geneProduct="Trx2"/>
+            </fbc:and>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -149134,6 +148569,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:5553404;PMID:5671058</p>
           </body>
         </notes>
         <annotation>
@@ -149146,6 +148582,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02016"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104766"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/TRDRm"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1433"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/20345"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -150513,12 +149950,12 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01641x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02578x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02633x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -150859,37 +150296,6 @@
           <speciesReference species="MAM02770m" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR03838" sboTerm="SBO:0000176" id="MAR03838" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:18506409</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR03838">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.5.99.8"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00559m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03102m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02770m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03103m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="slgA"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR03895" sboTerm="SBO:0000176" id="MAR03895" name="ATP:L-glutamate 5-phosphotransferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -152040,13 +151446,13 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02504x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01250x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02923x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -152142,13 +151548,13 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02503x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01250x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02812x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -152212,13 +151618,13 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02501x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01250x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02503x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -152803,6 +152209,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:18506409</p>
           </body>
         </notes>
         <annotation>
@@ -152980,6 +152387,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:12855692;PMID:6401712;PMID:6874697;PMID:3597357</p>
           </body>
         </notes>
         <annotation>
@@ -152988,8 +152396,12 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.12"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACOAD9m"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02660"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/ACOAD9m"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0560"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -153004,13 +152416,17 @@
           <speciesReference species="MAM02180m" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CG3902"/>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="Arc42"/>
+            <fbc:geneProductRef fbc:geneProduct="CG3902"/>
+          </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR03770" sboTerm="SBO:0000176" id="MAR03770" name="3-methylbutanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:3597357;PMID:9214289</p>
           </body>
         </notes>
         <annotation>
@@ -153018,10 +152434,13 @@
             <rdf:Description rdf:about="#MAR03770">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.4"/>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.5"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACOAD8m"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04095"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95318"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/ACOAD8m"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0655"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -153036,7 +152455,10 @@
           <speciesReference species="MAM02189m" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CG3902"/>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="CG3902"/>
+            <fbc:geneProductRef fbc:geneProduct="CG6638"/>
+          </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR03771" sboTerm="SBO:0000176" id="MAR03771" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
@@ -153142,6 +152564,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:6401712</p>
           </body>
         </notes>
         <annotation>
@@ -153150,8 +152573,13 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.12"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACOAD10m"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03172"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR108000"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/ACOAD10m"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0603"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -153166,7 +152594,10 @@
           <speciesReference species="MAM02999m" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CG3902"/>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="Arc42"/>
+            <fbc:geneProductRef fbc:geneProduct="CG3902"/>
+          </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR03839" sboTerm="SBO:0000176" id="MAR03839" name="3-Phospho-D-glycerate:NAD+ 2-oxidoreductase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
@@ -153374,14 +152805,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02880x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01831x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01986x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:geneProductRef fbc:geneProduct="Sardh"/>
@@ -154071,14 +153502,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01986x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02007x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02578x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -154713,12 +154144,12 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG33054"/>
             <fbc:geneProductRef fbc:geneProduct="Ntan1"/>
             <fbc:geneProductRef fbc:geneProduct="Sirt1"/>
             <fbc:geneProductRef fbc:geneProduct="Sirt2"/>
             <fbc:geneProductRef fbc:geneProduct="Sirt6"/>
             <fbc:geneProductRef fbc:geneProduct="Sirt7"/>
+            <fbc:geneProductRef fbc:geneProduct="Targ1"/>
             <fbc:geneProductRef fbc:geneProduct="tun"/>
           </fbc:or>
         </fbc:geneProductAssociation>
@@ -154818,12 +154249,12 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG33054"/>
             <fbc:geneProductRef fbc:geneProduct="Ntan1"/>
             <fbc:geneProductRef fbc:geneProduct="Sirt1"/>
             <fbc:geneProductRef fbc:geneProduct="Sirt2"/>
             <fbc:geneProductRef fbc:geneProduct="Sirt6"/>
             <fbc:geneProductRef fbc:geneProduct="Sirt7"/>
+            <fbc:geneProductRef fbc:geneProduct="Targ1"/>
             <fbc:geneProductRef fbc:geneProduct="tun"/>
           </fbc:or>
         </fbc:geneProductAssociation>
@@ -154858,12 +154289,12 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG33054"/>
             <fbc:geneProductRef fbc:geneProduct="Ntan1"/>
             <fbc:geneProductRef fbc:geneProduct="Sirt1"/>
             <fbc:geneProductRef fbc:geneProduct="Sirt2"/>
             <fbc:geneProductRef fbc:geneProduct="Sirt6"/>
             <fbc:geneProductRef fbc:geneProduct="Sirt7"/>
+            <fbc:geneProductRef fbc:geneProduct="Targ1"/>
             <fbc:geneProductRef fbc:geneProduct="tun"/>
           </fbc:or>
         </fbc:geneProductAssociation>
@@ -155201,9 +154632,9 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="CG2604"/>
+            <fbc:geneProductRef fbc:geneProduct="CG5167"/>
             <fbc:geneProductRef fbc:geneProduct="LKRSDH"/>
-            <fbc:geneProductRef fbc:geneProduct="Sccpdh1"/>
-            <fbc:geneProductRef fbc:geneProduct="Sccpdh2"/>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -155765,14 +155196,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02426x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01157x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02578x" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
@@ -156931,34 +156362,6 @@
           <speciesReference species="MAM02458c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR09733" sboTerm="SBO:0000176" id="MAR09733" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR09733">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03674"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR108330"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_9733"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02355c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01596c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03162c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR03206" sboTerm="SBO:0000176" id="MAR03206" name="acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -156991,39 +156394,6 @@
           <speciesReference species="MAM02774m" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR03211" sboTerm="SBO:0000176" id="MAR03211" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10502673;PMID:3597357;PMID:4062874</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR03211">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.7"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00924"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103101"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0683"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02774m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03103m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01265m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03102m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Mcad"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR03747" sboTerm="SBO:0000176" id="MAR03747" name="L-Valine:2-oxoglutarate aminotransferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -157385,8 +156755,8 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="CG17691"/>
-            <fbc:geneProductRef fbc:geneProduct="CG8199"/>
+            <fbc:geneProductRef fbc:geneProduct="BckdhA"/>
+            <fbc:geneProductRef fbc:geneProduct="BckdhB"/>
           </fbc:and>
         </fbc:geneProductAssociation>
       </reaction>
@@ -157437,10 +156807,16 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.4.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/OIVD1m"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01702"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01651"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR107132"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95029"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102172"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR107999"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/OIVD1m"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0386"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25177"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -157457,8 +156833,8 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="CG17691"/>
-            <fbc:geneProductRef fbc:geneProduct="CG8199"/>
+            <fbc:geneProductRef fbc:geneProduct="BckdhA"/>
+            <fbc:geneProductRef fbc:geneProduct="BckdhB"/>
           </fbc:and>
         </fbc:geneProductAssociation>
       </reaction>
@@ -157475,10 +156851,16 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.168"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/OIVD1m"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04097"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01651"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR108654"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97452"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102172"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR107999"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/OIVD1m"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0656"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/25177"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -158034,46 +157416,11 @@
           <speciesReference species="MAM02578c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR04242" sboTerm="SBO:0000176" id="MAR04242" name="glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:3081514</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR04242">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.6"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02487"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100293"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0541"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/30847"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01977m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03103m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01596m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01622m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03102m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CG9547"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR04243" sboTerm="SBO:0000176" id="MAR04243" name="glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:3081514</p>
           </body>
         </notes>
         <annotation>
@@ -158084,7 +157431,9 @@
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.6"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLUTCOADHm"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02487"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100293"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/GLUTCOADHm"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0541"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/30847"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -161628,9 +160977,11 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/4.4.1.1"/>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/4.4.1.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r0193"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00782"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105313"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96994"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0193"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/24931"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -163692,12 +163043,12 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01638x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02578x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02819x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -163762,13 +163113,13 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01640x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01101x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02578x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -163798,13 +163149,13 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01740x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01073x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02578x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -163846,47 +163197,11 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="CG17691"/>
-            <fbc:geneProductRef fbc:geneProduct="CG8199"/>
+            <fbc:geneProductRef fbc:geneProduct="BckdhA"/>
+            <fbc:geneProductRef fbc:geneProduct="BckdhB"/>
           </fbc:and>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03751" sboTerm="SBO:0000176" id="MAR03751" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12855692;PMID:6401712;PMID:6874697;PMID:3597357</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR03751">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.12"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02660"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0560"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02180m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03103m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02468m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03102m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Arc42"/>
-            <fbc:geneProductRef fbc:geneProduct="CG3902"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR03753" sboTerm="SBO:0000176" id="MAR03753" name="(S)-3-Hydroxyisobutyryl-CoA hydro-lyase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -163923,7 +163238,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11580916;PMID:8188708</p>
+            <p>AUTHORS: PMID:11580916;PMID:8188708;PMID:8824301</p>
           </body>
         </notes>
         <annotation>
@@ -163932,9 +163247,12 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.2.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/3HBCOAHLm"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r0779"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03352"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR108112"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR94891"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/3HBCOAHLm"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0779"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/20888"/>
                 </rdf:Bag>
@@ -164033,79 +163351,6 @@
           <fbc:geneProductRef fbc:geneProduct="CG17896"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03767" sboTerm="SBO:0000176" id="MAR03767" name="4-methyl-2-oxopentanoate:NAD+ oxidoreductase (CoA-mehtylpropanoylating)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR03767">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.25"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/OIVD1m"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01651"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102172"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR107999"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/OIVD1m"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/25177"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01013m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01597m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02552m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01596m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02189m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02553m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="CG17691"/>
-            <fbc:geneProductRef fbc:geneProduct="CG8199"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR03769" sboTerm="SBO:0000176" id="MAR03769" name="3-methylbutanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:3597357;PMID:9214289</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR03769">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.4"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04095"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95318"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0655"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00826m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03102m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02189m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03103m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CG6638"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR03773" sboTerm="SBO:0000176" id="MAR03773" name="3-Methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -164217,48 +163462,11 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="CG17691"/>
-            <fbc:geneProductRef fbc:geneProduct="CG8199"/>
+            <fbc:geneProductRef fbc:geneProduct="BckdhA"/>
+            <fbc:geneProductRef fbc:geneProduct="BckdhB"/>
           </fbc:and>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03783" sboTerm="SBO:0000176" id="MAR03783" name="(S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:6401712</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR03783">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.12"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03172"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR108000"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0603"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00663m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03103m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02999m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03102m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Arc42"/>
-            <fbc:geneProductRef fbc:geneProduct="CG3902"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR03785" sboTerm="SBO:0000176" id="MAR03785" name="(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA hydro-liase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -164475,8 +163683,8 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="CG17691"/>
-            <fbc:geneProductRef fbc:geneProduct="CG8199"/>
+            <fbc:geneProductRef fbc:geneProduct="BckdhA"/>
+            <fbc:geneProductRef fbc:geneProduct="BckdhB"/>
           </fbc:and>
         </fbc:geneProductAssociation>
       </reaction>
@@ -170149,72 +169357,6 @@
           <speciesReference species="MAM03082c" stoichiometry="28" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR05173" sboTerm="SBO:0000176" id="MAR05173" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR05173">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_5173"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01371c" stoichiometry="1404" constant="true"/>
-          <speciesReference species="MAM02006c" stoichiometry="28" constant="true"/>
-          <speciesReference species="MAM02040c" stoichiometry="1405" constant="true"/>
-          <speciesReference species="MAM02335c" stoichiometry="31" constant="true"/>
-          <speciesReference species="MAM02340c" stoichiometry="19" constant="true"/>
-          <speciesReference species="MAM02341c" stoichiometry="19" constant="true"/>
-          <speciesReference species="MAM02342c" stoichiometry="27" constant="true"/>
-          <speciesReference species="MAM02351c" stoichiometry="19" constant="true"/>
-          <speciesReference species="MAM02376c" stoichiometry="16" constant="true"/>
-          <speciesReference species="MAM02377c" stoichiometry="34" constant="true"/>
-          <speciesReference species="MAM02380c" stoichiometry="13" constant="true"/>
-          <speciesReference species="MAM02401c" stoichiometry="29" constant="true"/>
-          <speciesReference species="MAM02404c" stoichiometry="47" constant="true"/>
-          <speciesReference species="MAM02405c" stoichiometry="33" constant="true"/>
-          <speciesReference species="MAM02408c" stoichiometry="15" constant="true"/>
-          <speciesReference species="MAM02412c" stoichiometry="22" constant="true"/>
-          <speciesReference species="MAM02415c" stoichiometry="20" constant="true"/>
-          <speciesReference species="MAM02416c" stoichiometry="37" constant="true"/>
-          <speciesReference species="MAM02419c" stoichiometry="18" constant="true"/>
-          <speciesReference species="MAM02421c" stoichiometry="14" constant="true"/>
-          <speciesReference species="MAM02423c" stoichiometry="27" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01285c" stoichiometry="1404" constant="true"/>
-          <speciesReference species="MAM02039c" stoichiometry="1863" constant="true"/>
-          <speciesReference species="MAM02751c" stoichiometry="1404" constant="true"/>
-          <speciesReference species="MAM02757c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03063c" stoichiometry="31" constant="true"/>
-          <speciesReference species="MAM03064c" stoichiometry="19" constant="true"/>
-          <speciesReference species="MAM03065c" stoichiometry="19" constant="true"/>
-          <speciesReference species="MAM03066c" stoichiometry="27" constant="true"/>
-          <speciesReference species="MAM03067c" stoichiometry="19" constant="true"/>
-          <speciesReference species="MAM03068c" stoichiometry="16" constant="true"/>
-          <speciesReference species="MAM03069c" stoichiometry="34" constant="true"/>
-          <speciesReference species="MAM03070c" stoichiometry="28" constant="true"/>
-          <speciesReference species="MAM03071c" stoichiometry="13" constant="true"/>
-          <speciesReference species="MAM03072c" stoichiometry="29" constant="true"/>
-          <speciesReference species="MAM03073c" stoichiometry="47" constant="true"/>
-          <speciesReference species="MAM03074c" stoichiometry="33" constant="true"/>
-          <speciesReference species="MAM03075c" stoichiometry="15" constant="true"/>
-          <speciesReference species="MAM03076c" stoichiometry="22" constant="true"/>
-          <speciesReference species="MAM03077c" stoichiometry="20" constant="true"/>
-          <speciesReference species="MAM03078c" stoichiometry="37" constant="true"/>
-          <speciesReference species="MAM03079c" stoichiometry="18" constant="true"/>
-          <speciesReference species="MAM03081c" stoichiometry="14" constant="true"/>
-          <speciesReference species="MAM03082c" stoichiometry="27" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR05174" sboTerm="SBO:0000176" id="MAR05174" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -171990,63 +171132,6 @@
           <fbc:geneProductRef fbc:geneProduct="Hacd1"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR05289" sboTerm="SBO:0000176" id="MAR05289" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR05289">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_5289"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01371l" stoichiometry="467" constant="true"/>
-          <speciesReference species="MAM02040l" stoichiometry="934" constant="true"/>
-          <speciesReference species="MAM02757l" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01285l" stoichiometry="467" constant="true"/>
-          <speciesReference species="MAM01307l" stoichiometry="31" constant="true"/>
-          <speciesReference species="MAM01365l" stoichiometry="19" constant="true"/>
-          <speciesReference species="MAM01369l" stoichiometry="19" constant="true"/>
-          <speciesReference species="MAM01370l" stoichiometry="27" constant="true"/>
-          <speciesReference species="MAM01628l" stoichiometry="19" constant="true"/>
-          <speciesReference species="MAM01974l" stoichiometry="34" constant="true"/>
-          <speciesReference species="MAM01975l" stoichiometry="16" constant="true"/>
-          <speciesReference species="MAM01986l" stoichiometry="28" constant="true"/>
-          <speciesReference species="MAM02039l" stoichiometry="476" constant="true"/>
-          <speciesReference species="MAM02125l" stoichiometry="13" constant="true"/>
-          <speciesReference species="MAM02184l" stoichiometry="29" constant="true"/>
-          <speciesReference species="MAM02360l" stoichiometry="47" constant="true"/>
-          <speciesReference species="MAM02426l" stoichiometry="33" constant="true"/>
-          <speciesReference species="MAM02471l" stoichiometry="15" constant="true"/>
-          <speciesReference species="MAM02724l" stoichiometry="22" constant="true"/>
-          <speciesReference species="MAM02751l" stoichiometry="467" constant="true"/>
-          <speciesReference species="MAM02770l" stoichiometry="20" constant="true"/>
-          <speciesReference species="MAM02896l" stoichiometry="37" constant="true"/>
-          <speciesReference species="MAM02993l" stoichiometry="18" constant="true"/>
-          <speciesReference species="MAM03101l" stoichiometry="14" constant="true"/>
-          <speciesReference species="MAM03135l" stoichiometry="27" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Bace"/>
-            <fbc:geneProductRef fbc:geneProduct="CG11459"/>
-            <fbc:geneProductRef fbc:geneProduct="Cp1"/>
-            <fbc:geneProductRef fbc:geneProduct="CtsB"/>
-            <fbc:geneProductRef fbc:geneProduct="CtsF"/>
-            <fbc:geneProductRef fbc:geneProduct="cathD"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR05290" sboTerm="SBO:0000176" id="MAR05290" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -172984,11 +172069,12 @@
           <fbc:geneProductRef fbc:geneProduct="Mdh2"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR04145" sboTerm="SBO:0000176" id="MAR04145" name="acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR04145" sboTerm="SBO:0000176" id="MAR04145" name="acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
             <p>AUTHORS: PMID:12549038</p>
+            <p>NOTES: Essentials of Medical Biochemistry: With Clinical Cases (2011) page 130, ISBN:978008091688</p>
           </body>
         </notes>
         <annotation>
@@ -173010,14 +172096,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01587m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01597m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01261m" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040m" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02633m" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01587m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01597m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:geneProductRef fbc:geneProduct="kdn"/>
@@ -173393,10 +172479,15 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.5.1"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r0509"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SUCD1m"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00408"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02164"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR107340"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99636"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0509"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SUCD1m"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/13713"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/30343"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -173514,13 +172605,13 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02007x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02661x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -173550,56 +172641,17 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01998x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02007x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:geneProductRef fbc:geneProduct="Hao"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR08743" sboTerm="SBO:0000176" id="MAR08743" name="succinate:FAD oxidoreductase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR08743">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.5.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SUCD1m"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00408"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99636"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SUCD1m"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/30343"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01803m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01862m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01802m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02943m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="SdhA"/>
-            <fbc:geneProductRef fbc:geneProduct="SdhB"/>
-            <fbc:geneProductRef fbc:geneProduct="SdhC"/>
-            <fbc:geneProductRef fbc:geneProduct="SdhD"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR08772" sboTerm="SBO:0000176" id="MAR08772" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -174570,8 +173622,8 @@
           <speciesReference species="MAM02631x" stoichiometry="2" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:geneProductRef fbc:geneProduct="Sod1"/>
@@ -179532,7 +178584,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02174" sboTerm="SBO:0000176" id="MAR02174" name="(3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02174" sboTerm="SBO:0000176" id="MAR02174" name="(3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -179785,45 +178837,6 @@
           <fbc:geneProductRef fbc:geneProduct="FASN2"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR04156" sboTerm="SBO:0000176" id="MAR04156" name="acetyl-CoA:carbon-dioxide ligase (ADP-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:7732023;PMID:16854592;PMID:18455495;PMID:10677481;PMID:16721829;PMID:17126822;PMID:235695;PMID:24055;PMID:6116153;PMID:6116159;PMID:6116163;PMID:6138355;PMID:7732023;PMID:9099716</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR04156">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.4.1.2"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACCOAC"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00742"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95219"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/ACCOAC"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/11309"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/11308"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01261c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02046c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01285c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02444c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02751c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="ACC"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR04295" sboTerm="SBO:0000176" id="MAR04295" name="acetyl-CoA:carbon-dioxide ligase (ADP-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -179850,14 +178863,11 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01261m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01371m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02046m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01422m" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM01285m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02444m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02751m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01357m" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:geneProductRef fbc:geneProduct="ACC"/>
@@ -185391,9 +184401,9 @@
           <speciesReference species="MAM02444c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM00902c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01596c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00853c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction metaid="MAR02499" sboTerm="SBO:0000176" id="MAR02499" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -185417,9 +184427,9 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00902c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02555c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00853c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00718c" stoichiometry="1" constant="true"/>
@@ -185518,11 +184528,11 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM00113x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01664x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -187269,7 +186279,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10970790;PMID:10970790</p>
+            <p>AUTHORS: PMID:10970790;PMID:10970790;PMID:10970790</p>
           </body>
         </notes>
         <annotation>
@@ -187278,7 +186288,9 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.1.93"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RE3150C"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103806"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE3150C"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -187347,10 +186359,10 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM00110x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03028x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -187973,8 +186985,8 @@
             <fbc:geneProductRef fbc:geneProduct="CG4592"/>
             <fbc:geneProductRef fbc:geneProduct="CG4594"/>
             <fbc:geneProductRef fbc:geneProduct="CG4598"/>
+            <fbc:geneProductRef fbc:geneProduct="CG9577"/>
             <fbc:geneProductRef fbc:geneProduct="Dci"/>
-            <fbc:geneProductRef fbc:geneProduct="Ech1"/>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -188289,11 +187301,11 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01364x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00682x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -188434,12 +187446,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01934x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00073x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -188560,11 +187572,11 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM00091x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00072x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -188740,6 +187752,9 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.14.14.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.14.15.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R07041"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR110751"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -193260,11 +192275,11 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01120x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01119x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -194035,11 +193050,11 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01122x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01121x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -194805,11 +193820,11 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM00582x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00026x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -195209,11 +194224,11 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM00258x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01037x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -195691,11 +194706,11 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM00587x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00027x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -195819,12 +194834,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02650x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00423x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction metaid="MAR01298" sboTerm="SBO:0000176" id="MAR01298" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
@@ -195965,13 +194980,13 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="3" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02652x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00015x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -196504,6 +195519,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:12828998;PMID:9498103;PMID:3955080</p>
           </body>
         </notes>
         <annotation>
@@ -196512,7 +195528,9 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.21"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/C120CPT1"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HMR_2602"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/C120CPT1"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_2602"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -207506,7 +206524,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:7821823;PMID:8687421;PMID:8163052</p>
+            <p>AUTHORS: PMID:11955283;PMID:2115809;PMID:2923620;PMID:3338458;PMID:340460;PMID:8401296;PMID:8549872;PMID:8579375;PMID:9171333;PMID:9244403;PMID:9559543;PMID:7821823;PMID:8687421;PMID:8163052</p>
           </body>
         </notes>
         <annotation>
@@ -207516,10 +206534,14 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.5.3"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00848"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00849"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99875"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106713"/>
                   <rdf:li rdf:resource="https://identifiers.org/reactome/R-HSA-188467"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/GLYC3PFADm"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0205"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/31283"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18977"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -208354,14 +207376,14 @@
         <listOfReactants>
           <speciesReference species="MAM00317x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="11" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="7" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="11" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="11" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="7" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="12" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="7" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="11" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="7" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="11" constant="true"/>
         </listOfProducts>
       </reaction>
@@ -208385,14 +207407,14 @@
         <listOfReactants>
           <speciesReference species="MAM00134x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="11" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="6" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="11" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="11" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="6" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="12" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="6" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="11" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="6" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="11" constant="true"/>
         </listOfProducts>
       </reaction>
@@ -208416,14 +207438,14 @@
         <listOfReactants>
           <speciesReference species="MAM00131x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="11" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="11" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="11" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="11" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="11" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="12" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="11" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="3" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="11" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="11" constant="true"/>
         </listOfProducts>
       </reaction>
@@ -208449,12 +207471,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02110x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00049x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -208581,12 +207603,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02971x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00064x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -208703,11 +207725,11 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01725x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00040x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -208824,11 +207846,11 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01773x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00043x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -208944,12 +207966,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02941x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00057x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -209073,12 +208095,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02678x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00051x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -209208,12 +208230,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02495x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00066x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -209344,12 +208366,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02345x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00042x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -209485,11 +208507,11 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01650x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -209622,12 +208644,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02644x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00059x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -209756,12 +208778,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02122x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00053x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -209888,11 +208910,11 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01412x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01622x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -210009,15 +209031,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="10" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="10" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="10" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="10" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="10" constant="true"/>
           <speciesReference species="MAM03047x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="10" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="10" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="10" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="10" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="10" constant="true"/>
           <speciesReference species="MAM02774x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -210041,11 +209063,11 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02112x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03016x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -210163,10 +209185,10 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM00025x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03015x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -210284,10 +209306,10 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM00016x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03013x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -210405,10 +209427,10 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM00007x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03012x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -210525,11 +209547,11 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02647x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03025x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -210648,10 +209670,10 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01191x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03019x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -210773,10 +209795,10 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01141x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03022x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -210908,39 +209930,6 @@
           <speciesReference species="MAM00088x" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR03364" sboTerm="SBO:0000176" id="MAR03364" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:1047780;PMID:8973539;PMID:11135616</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR03364">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02677x" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03020x" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR03365" sboTerm="SBO:0000176" id="MAR03365" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -211032,39 +210021,6 @@
           <fbc:geneProductRef fbc:geneProduct="didum"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03369" sboTerm="SBO:0000176" id="MAR03369" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:1047780;PMID:8973539;PMID:11135616</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR03369">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00118x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03023x" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR03370" sboTerm="SBO:0000176" id="MAR03370" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -211325,10 +210281,10 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM00078x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03027x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -211456,11 +210412,11 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM00948x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00090x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -211610,11 +210566,11 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM00080x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00079x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -211718,55 +210674,31 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#meta_MAR03517">
-              <bqbiol:is>
-                <rdf:Bag/>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00933c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00933x" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR03301" sboTerm="SBO:0000176" id="MAR03301" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:8973539;PMID:10407780;PMID:11356167</p>
+            <p>AUTHORS: PMID:1703300</p>
           </body>
         </notes>
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR03301">
+            <rdf:Description rdf:about="#MAR03517">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.5.1.10"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SCP22x"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104294"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SCP22x"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02391x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00933c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03010x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00933x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
-          </fbc:or>
+          <fbc:geneProductRef fbc:geneProduct="ScpX"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR03302" sboTerm="SBO:0000176" id="MAR03302" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -211860,39 +210792,6 @@
           <fbc:geneProductRef fbc:geneProduct="didum"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03306" sboTerm="SBO:0000176" id="MAR03306" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:8973539;PMID:10407780;PMID:11356167</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR03306">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01577x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03009x" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR03307" sboTerm="SBO:0000176" id="MAR03307" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -211984,39 +210883,6 @@
           <fbc:geneProductRef fbc:geneProduct="didum"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03311" sboTerm="SBO:0000176" id="MAR03311" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:8973539;PMID:10407780;PMID:11356167</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR03311">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01576x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03030x" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR03312" sboTerm="SBO:0000176" id="MAR03312" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -212654,7 +211520,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:13295225;PMID:1540149</p>
+            <p>AUTHORS: PMID:13295225;PMID:1540149;PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265</p>
           </body>
         </notes>
         <annotation>
@@ -212666,9 +211532,12 @@
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.8"/>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.9"/>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r0310"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01279"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR125070"/>
                   <rdf:li rdf:resource="https://identifiers.org/reactome/R-HSA-77299"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0310"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_3121"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/30747"/>
                 </rdf:Bag>
@@ -212793,7 +211662,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:13295225;PMID:1540149</p>
+            <p>AUTHORS: PMID:13295225;PMID:1540149;PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265</p>
           </body>
         </notes>
         <annotation>
@@ -212805,9 +211674,12 @@
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.8"/>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.9"/>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1449"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03990"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95300"/>
                   <rdf:li rdf:resource="https://identifiers.org/reactome/R-HSA-77274"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1449"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_3128"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/28358"/>
                 </rdf:Bag>
@@ -212825,7 +211697,9 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
             <fbc:geneProductRef fbc:geneProduct="Acadvl"/>
+            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
             <fbc:geneProductRef fbc:geneProduct="Egm"/>
             <fbc:geneProductRef fbc:geneProduct="Mcad"/>
           </fbc:or>
@@ -212931,7 +211805,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:13295225;PMID:1540149</p>
+            <p>AUTHORS: PMID:13295225;PMID:1540149;PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265</p>
           </body>
         </notes>
         <annotation>
@@ -212943,9 +211817,12 @@
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.8"/>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.9"/>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1447"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03857"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95299"/>
                   <rdf:li rdf:resource="https://identifiers.org/reactome/R-HSA-77263"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1447"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_3135"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/31039"/>
                 </rdf:Bag>
@@ -212973,7 +211850,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:8012501;PMID:8188243;PMID:13295248</p>
+            <p>AUTHORS: PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265;PMID:8012501;PMID:8188243;PMID:13295248</p>
           </body>
         </notes>
         <annotation>
@@ -212981,9 +211858,12 @@
             <rdf:Description rdf:about="#MAR03136">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.17"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1446"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04170"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97890"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1446"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0660"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/31075"/>
                 </rdf:Bag>
@@ -213070,7 +211950,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:13295225;PMID:3597357</p>
+            <p>AUTHORS: PMID:13295225;PMID:3597357;PMID:17603022;PMID:1774065;PMID:6240978;PMID:7876265</p>
           </body>
         </notes>
         <annotation>
@@ -213080,9 +211960,12 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.7"/>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1451"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04754"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR109095"/>
                   <rdf:li rdf:resource="https://identifiers.org/reactome/R-HSA-77345"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1451"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_3142"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/28354"/>
                 </rdf:Bag>
@@ -213100,6 +211983,8 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
+            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
             <fbc:geneProductRef fbc:geneProduct="Egm"/>
             <fbc:geneProductRef fbc:geneProduct="Mcad"/>
           </fbc:or>
@@ -213205,7 +212090,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:13295225;PMID:3597357</p>
+            <p>AUTHORS: PMID:17603022;PMID:1774065;PMID:13295225;PMID:3597357;PMID:6240978;PMID:7876265</p>
           </body>
         </notes>
         <annotation>
@@ -213215,9 +212100,12 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.7"/>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1448"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03777"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95304"/>
                   <rdf:li rdf:resource="https://identifiers.org/reactome/R-HSA-77338"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1448"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_3149"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/30943"/>
                 </rdf:Bag>
@@ -213235,6 +212123,8 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
+            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
             <fbc:geneProductRef fbc:geneProduct="Egm"/>
             <fbc:geneProductRef fbc:geneProduct="Mcad"/>
           </fbc:or>
@@ -213340,7 +212230,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:13295225;PMID:3597357</p>
+            <p>AUTHORS: PMID:13295225;PMID:3597357;PMID:17603022;PMID:1774065;PMID:6240978;PMID:7876265</p>
           </body>
         </notes>
         <annotation>
@@ -213349,9 +212239,12 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.8.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1450"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04751"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR109093"/>
                   <rdf:li rdf:resource="https://identifiers.org/reactome/R-HSA-77327"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1450"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_3156"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/31207"/>
                 </rdf:Bag>
@@ -213368,7 +212261,11 @@
           <speciesReference species="MAM01803m" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CG3902"/>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
+            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
+            <fbc:geneProductRef fbc:geneProduct="CG3902"/>
+          </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR03157" sboTerm="SBO:0000176" id="MAR03157" name="(S)-Hydroxyhexanoyl-CoA hydro-lyase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -216008,8 +214905,8 @@
             <fbc:geneProductRef fbc:geneProduct="CG4592"/>
             <fbc:geneProductRef fbc:geneProduct="CG4594"/>
             <fbc:geneProductRef fbc:geneProduct="CG4598"/>
+            <fbc:geneProductRef fbc:geneProduct="CG9577"/>
             <fbc:geneProductRef fbc:geneProduct="Dci"/>
-            <fbc:geneProductRef fbc:geneProduct="Ech1"/>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -216033,10 +214930,10 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM00018x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03014x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -216154,10 +215051,10 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01586x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03024x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -216899,8 +215796,8 @@
             <fbc:geneProductRef fbc:geneProduct="CG4592"/>
             <fbc:geneProductRef fbc:geneProduct="CG4594"/>
             <fbc:geneProductRef fbc:geneProduct="CG4598"/>
+            <fbc:geneProductRef fbc:geneProduct="CG9577"/>
             <fbc:geneProductRef fbc:geneProduct="Dci"/>
-            <fbc:geneProductRef fbc:geneProduct="Ech1"/>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -217310,8 +216207,8 @@
             <fbc:geneProductRef fbc:geneProduct="CG4592"/>
             <fbc:geneProductRef fbc:geneProduct="CG4594"/>
             <fbc:geneProductRef fbc:geneProduct="CG4598"/>
+            <fbc:geneProductRef fbc:geneProduct="CG9577"/>
             <fbc:geneProductRef fbc:geneProduct="Dci"/>
-            <fbc:geneProductRef fbc:geneProduct="Ech1"/>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -218893,69 +217790,6 @@
           <speciesReference species="MAM10010c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR01644" sboTerm="SBO:0000176" id="MAR01644" name="(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming]" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10709654</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR01644">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.107"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04813"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_1644"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/18933"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00749m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02040m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00036m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Mfe2"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR01651" sboTerm="SBO:0000176" id="MAR01651" name="(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA:NAD+ oxidoreductase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10709654</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR01651">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.35"/>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.211"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04812"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_1651"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00036m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02552m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00748m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02553m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR01924" sboTerm="SBO:0000176" id="MAR01924" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -219244,7 +218078,7 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00759c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01314c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02554c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
@@ -235273,44 +234107,11 @@
           <fbc:geneProductRef fbc:geneProduct="Gpdh1"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00483" sboTerm="SBO:0000176" id="MAR00483" name="sn-glycerol 3-phosphate:quinone oxidoreductase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11955283;PMID:2115809;PMID:2923620;PMID:3338458;PMID:340460;PMID:8401296;PMID:8549872;PMID:8579375;PMID:9171333;PMID:9244403;PMID:9559543</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00483">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.5.3"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00849"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106713"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0205"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/18977"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02914c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03103m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01690c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03102m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Gpo1"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR00482" sboTerm="SBO:0000176" id="MAR00482" name="sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11955283;PMID:2115809;PMID:2923620;PMID:3338458;PMID:340460;PMID:8401296;PMID:8549872;PMID:8579375;PMID:9171333;PMID:9244403;PMID:9559543</p>
           </body>
         </notes>
         <annotation>
@@ -235321,9 +234122,13 @@
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.5.3"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G3PD2m"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00848"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00849"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99875"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106713"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_0482"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0205"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/31283"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18977"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -242721,274 +241526,6 @@
           <speciesReference species="MAM10005c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR00024" sboTerm="SBO:0000176" id="MAR00024" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00024">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_0024"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01816n" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02757n" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01268n" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="HDAC3"/>
-              <fbc:geneProductRef fbc:geneProduct="Smr"/>
-              <fbc:geneProductRef fbc:geneProduct="ebi"/>
-            </fbc:and>
-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="nej"/>
-              <fbc:geneProductRef fbc:geneProduct="tai"/>
-            </fbc:and>
-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="Sin3A"/>
-              <fbc:geneProductRef fbc:geneProduct="Smr"/>
-            </fbc:and>
-            <fbc:and>
-              <fbc:geneProductRef fbc:geneProduct="HDAC3"/>
-              <fbc:geneProductRef fbc:geneProduct="Sin3A"/>
-              <fbc:geneProductRef fbc:geneProduct="Smr"/>
-            </fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="Art4"/>
-            <fbc:geneProductRef fbc:geneProduct="Eip75B"/>
-            <fbc:geneProductRef fbc:geneProduct="Hr3"/>
-            <fbc:geneProductRef fbc:geneProduct="Ncoa6"/>
-            <fbc:geneProductRef fbc:geneProduct="Tgs1"/>
-            <fbc:geneProductRef fbc:geneProduct="tai"/>
-            <fbc:geneProductRef fbc:geneProduct="usp"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR00025" sboTerm="SBO:0000185" id="MAR00025" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12505311;PMID:14999402;PMID:19710929;PMID:17604218;PMID:16476485;PMID:18288277;PMID:16503871;PMID:10529898;PMID:11330046</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00025">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_0025"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01268n" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01268c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Men"/>
-            <fbc:geneProductRef fbc:geneProduct="Rgl"/>
-            <fbc:geneProductRef fbc:geneProduct="St2"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR00026" sboTerm="SBO:0000185" id="MAR00026" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12505311;PMID:14999402;PMID:19710929;PMID:17604218;PMID:16476485;PMID:18288277;PMID:16503871;PMID:10529898;PMID:11330046</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00026">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_0026"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01268c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01268r" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Hmgcr"/>
-            <fbc:geneProductRef fbc:geneProduct="Ugt302K1"/>
-            <fbc:geneProductRef fbc:geneProduct="Ugt49B2"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR00027" sboTerm="SBO:0000185" id="MAR00027" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12505311;PMID:14999402;PMID:19710929;PMID:17604218;PMID:16476485;PMID:18288277;PMID:16503871;PMID:10529898;PMID:11330046</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00027">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_0027"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01268c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01268m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Alas"/>
-            <fbc:geneProductRef fbc:geneProduct="CG3961"/>
-            <fbc:geneProductRef fbc:geneProduct="CPT2"/>
-            <fbc:geneProductRef fbc:geneProduct="Hmgs"/>
-            <fbc:geneProductRef fbc:geneProduct="Mcad"/>
-            <fbc:geneProductRef fbc:geneProduct="whd"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR00028" sboTerm="SBO:0000185" id="MAR00028" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12505311;PMID:14999402;PMID:19710929;PMID:17604218;PMID:16476485;PMID:18288277;PMID:16503871;PMID:10529898;PMID:11330046</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00028">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_0028"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01268c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01268x" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-            <fbc:geneProductRef fbc:geneProduct="Pex11ab"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR00029" sboTerm="SBO:0000185" id="MAR00029" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12505311;PMID:14999402;PMID:19710929;PMID:17604218;PMID:16476485;PMID:18288277;PMID:16503871;PMID:10529898;PMID:11330046</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00029">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_0029"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01268c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01268e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG9593"/>
-            <fbc:geneProductRef fbc:geneProduct="Mdr50"/>
-            <fbc:geneProductRef fbc:geneProduct="Snmp2"/>
-            <fbc:geneProductRef fbc:geneProduct="Spn77Bb"/>
-            <fbc:geneProductRef fbc:geneProduct="Spn77Bc"/>
-            <fbc:geneProductRef fbc:geneProduct="Spn85F"/>
-            <fbc:geneProductRef fbc:geneProduct="sca"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR00030" sboTerm="SBO:0000185" id="MAR00030" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12505311;PMID:14999402;PMID:19710929;PMID:17604218;PMID:16476485;PMID:18288277;PMID:16503871;PMID:10529898;PMID:11330046</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00030">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_0030"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01268c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01268n" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Mcad"/>
-            <fbc:geneProductRef fbc:geneProduct="Mdr50"/>
-            <fbc:geneProductRef fbc:geneProduct="Mtp"/>
-            <fbc:geneProductRef fbc:geneProduct="Pdk"/>
-            <fbc:geneProductRef fbc:geneProduct="Pex11ab"/>
-            <fbc:geneProductRef fbc:geneProduct="SREBP"/>
-            <fbc:geneProductRef fbc:geneProduct="Snmp2"/>
-            <fbc:geneProductRef fbc:geneProduct="St2"/>
-            <fbc:geneProductRef fbc:geneProduct="Ugt302C1"/>
-            <fbc:geneProductRef fbc:geneProduct="Ugt49B1"/>
-            <fbc:geneProductRef fbc:geneProduct="Ugt49C1"/>
-            <fbc:geneProductRef fbc:geneProduct="Yp1"/>
-            <fbc:geneProductRef fbc:geneProduct="Yp2"/>
-            <fbc:geneProductRef fbc:geneProduct="Yp3"/>
-            <fbc:geneProductRef fbc:geneProduct="bmm"/>
-            <fbc:geneProductRef fbc:geneProduct="mdy"/>
-            <fbc:geneProductRef fbc:geneProduct="sca"/>
-            <fbc:geneProductRef fbc:geneProduct="sxe2"/>
-            <fbc:geneProductRef fbc:geneProduct="whd"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR07200" sboTerm="SBO:0000176" id="MAR07200" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -246184,7 +244721,7 @@
           <speciesReference species="MAM02073l" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CG6903"/>
+          <fbc:geneProductRef fbc:geneProduct="Hgsnat"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR07229" sboTerm="SBO:0000176" id="MAR07229" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -246347,7 +244884,7 @@
           <speciesReference species="MAM02078l" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CG6903"/>
+          <fbc:geneProductRef fbc:geneProduct="Hgsnat"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR07234" sboTerm="SBO:0000176" id="MAR07234" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -246542,7 +245079,7 @@
           <speciesReference species="MAM02060l" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CG6903"/>
+          <fbc:geneProductRef fbc:geneProduct="Hgsnat"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR07240" sboTerm="SBO:0000176" id="MAR07240" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -246734,7 +245271,7 @@
           <speciesReference species="MAM02067l" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CG6903"/>
+          <fbc:geneProductRef fbc:geneProduct="Hgsnat"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR07246" sboTerm="SBO:0000176" id="MAR07246" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -252161,84 +250698,11 @@
           <fbc:geneProductRef fbc:geneProduct="Amacr"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01635" sboTerm="SBO:0000176" id="MAR01635" name="3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA 25-epimerase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11864182;PMID:11060344;PMID:10709654;PMID:11060344;PMID:11060344</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR01635">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.1.99.4"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R08734"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR112240"/>
-                  <rdf:li rdf:resource="https://identifiers.org/reactome/R-HSA-192056"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_1635"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE2624M"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/40456"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/40455"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00616m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00618m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Amacr"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR01637" sboTerm="SBO:0000176" id="MAR01637" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10709654</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR01637">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.17.99.-"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105369"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR124225"/>
-                  <rdf:li rdf:resource="https://identifiers.org/reactome/R-HSA-192335"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_1637"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE3247M"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00618m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00749m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR01638" sboTerm="SBO:0000176" id="MAR01638" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11356170;PMID:8943006</p>
           </body>
         </notes>
         <annotation>
@@ -252249,46 +250713,10 @@
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.17.99.-"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACOX2x"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/ACOX2x"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00618x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00749x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02040x" stoichiometry="2" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR01639" sboTerm="SBO:0000176" id="MAR01639" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11356170;PMID:8943006</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR01639">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.17.99.-"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105369"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR124225"/>
                   <rdf:li rdf:resource="https://identifiers.org/reactome/R-HSA-192335"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/ACOX2x"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE3247X"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0706"/>
                 </rdf:Bag>
@@ -252298,11 +250726,13 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM00618x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00749x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02040x" stoichiometry="2" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -252315,7 +250745,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:8902629</p>
+            <p>AUTHORS: PMID:8902629;PMID:10709654</p>
           </body>
         </notes>
         <annotation>
@@ -252351,7 +250781,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11330072</p>
+            <p>AUTHORS: PMID:11330072;PMID:10709654</p>
           </body>
         </notes>
         <annotation>
@@ -252423,77 +250853,11 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01653" sboTerm="SBO:0000176" id="MAR01653" name="3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:1121274;PMID:11356164;PMID:6378901</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR01653">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.176"/>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.16"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SCPx"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03719"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104297"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR108369"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_1653"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/16865"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00748m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01597m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01514m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02774m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="ScpX"/>
-            <fbc:geneProductRef fbc:geneProduct="didum"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR01656" sboTerm="SBO:0000185" id="MAR01656" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10884298;PMID:6469982</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR01656">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105412"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0990"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01514c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01514x" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR01659" sboTerm="SBO:0000185" id="MAR01659" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:18619829</p>
+            <p>AUTHORS: PMID:18619829;PMID:6469982</p>
           </body>
         </notes>
         <annotation>
@@ -253177,18 +251541,18 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM00617x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00755x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction metaid="MAR01706" sboTerm="SBO:0000176" id="MAR01706" name="(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA-forming]" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:8902629</p>
+            <p>AUTHORS: PMID:8902629;PMID:19357427</p>
           </body>
         </notes>
         <annotation>
@@ -253346,6 +251710,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:19131563;PMID:16949895</p>
           </body>
         </notes>
         <annotation>
@@ -253354,6 +251719,8 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/2.8.2.14"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HC02220c"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC02220c"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -255455,7 +253822,9 @@
             <rdf:Description rdf:about="#MAR01853">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r0993"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105414"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0993"/>
                   <rdf:li rdf:resource="https://identifiers.org/tcdb/3.A.1.208.2"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -255489,7 +253858,9 @@
             <rdf:Description rdf:about="#MAR01854">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r0994"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105415"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0994"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -255665,7 +254036,9 @@
             <rdf:Description rdf:about="#MAR01864">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1495"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105478"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1495"/>
                   <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.28.1.1"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -256404,7 +254777,9 @@
             <rdf:Description rdf:about="#MAR01886">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r2157"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106054"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r2157"/>
                   <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.60.1.14"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -256442,7 +254817,9 @@
             <rdf:Description rdf:about="#MAR01887">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r2158"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106055"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r2158"/>
                   <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.60.1.14"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -256480,7 +254857,9 @@
             <rdf:Description rdf:about="#MAR01888">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r2159"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106056"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r2159"/>
                   <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.60.1.14"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -260176,7 +258555,7 @@
           <speciesReference species="MAM02040c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CG6910"/>
+          <fbc:geneProductRef fbc:geneProduct="Miox"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR06540" sboTerm="SBO:0000176" id="MAR06540" name="1D-myo-inositol 1-phosphate phosphohydrolase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -267477,8 +265856,15 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.1"/>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.105"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HMR_6633"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RDH1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HMR_6633"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_RDH1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_TRETINOLOR1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TRETINOLOR1"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02124"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR189842"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RDH1"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/21284"/>
                 </rdf:Bag>
@@ -276902,7 +275288,16 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.11.1.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CAT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CATm"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CATp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CATpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CATr"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_CAT"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_CATm"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_CATp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_CATpp"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_CATr"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00009"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96455"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/CATp"/>
@@ -276914,11 +275309,11 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02041x" stoichiometry="2" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="2" constant="true"/>
         </listOfReactants>
         <listOfProducts>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="2" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -277709,7 +276104,7 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Parp"/>
+            <fbc:geneProductRef fbc:geneProduct="Parp1"/>
             <fbc:geneProductRef fbc:geneProduct="Parp16"/>
             <fbc:geneProductRef fbc:geneProduct="Tnks"/>
           </fbc:or>
@@ -278431,7 +276826,7 @@
           <speciesReference species="MAM02755c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR09508" sboTerm="SBO:0000176" id="MAR09508" name="GTP:mRNA guanylyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR09508" sboTerm="SBO:0000176" id="MAR09508" name="GTP:mRNA guanylyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -278904,7 +277299,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR09523" sboTerm="SBO:0000176" id="MAR09523" name="delta2-isopentenyl-diphosphate:tRNA isopentenyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR09523" sboTerm="SBO:0000176" id="MAR09523" name="delta2-isopentenyl-diphosphate:tRNA isopentenyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -278926,12 +277321,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03060c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01706c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03083c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM03060c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:geneProductRef fbc:geneProduct="CG31381"/>
@@ -279405,7 +277800,7 @@
           <fbc:geneProductRef fbc:geneProduct="Loxl2"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR09546" sboTerm="SBO:0000176" id="MAR09546" name="RNA-3&apos;-phosphate:RNA ligase (cyclizing, AMP-forming)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR09546" sboTerm="SBO:0000176" id="MAR09546" name="RNA-3&apos;-phosphate:RNA ligase (cyclizing, AMP-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -279427,13 +277822,13 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02848c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
           <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02849c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02848c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:geneProductRef fbc:geneProduct="Rtca"/>
@@ -280069,7 +278464,7 @@
           <speciesReference species="MAM00773x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Ech1"/>
+          <fbc:geneProductRef fbc:geneProduct="CG9577"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR09567" sboTerm="SBO:0000176" id="MAR09567" name="3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -280132,7 +278527,7 @@
           <speciesReference species="MAM00773x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Ech1"/>
+          <fbc:geneProductRef fbc:geneProduct="CG9577"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR09571" sboTerm="SBO:0000176" id="MAR09571" name="(5-glutamyl)-peptide:amino-acid 5-glutamyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -286094,17 +284489,22 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00440" sboTerm="SBO:0000185" id="MAR00440" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00440" sboTerm="SBO:0000185" id="MAR00440" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
           </body>
         </notes>
         <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#meta_MAR00440">
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR00440">
               <bqbiol:is>
-                <rdf:Bag/>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.14.99.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PHYTt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102660"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PHYTt"/>
+                </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
@@ -315047,117 +313447,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR06142" sboTerm="SBO:0000185" id="MAR06142" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:14579113;PMID:11076396</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR06142">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106133"/>
-                  <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.60.1.5"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00591c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01980e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02046e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00591e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01980c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02046c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Da"/>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Db"/>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Dc"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR06143" sboTerm="SBO:0000185" id="MAR06143" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:14579113;PMID:11076396</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR06143">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106134"/>
-                  <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.60.1.5"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00591c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02046e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02900e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00591e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02046c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02900c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Da"/>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Db"/>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Dc"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR06144" sboTerm="SBO:0000185" id="MAR06144" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:14579113;PMID:11076396</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR06144">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106135"/>
-                  <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.60.1.5"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00591c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02046e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02901e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00591e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02046c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02901c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Da"/>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Db"/>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Dc"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR06145" sboTerm="SBO:0000185" id="MAR06145" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -318008,43 +316297,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR06220" sboTerm="SBO:0000185" id="MAR06220" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11076394;PMID:11076396;PMID:14579113</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR06220">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106212"/>
-                  <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.60.1.2"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00591c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02026e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02046e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00591e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02026c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02046c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Da"/>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Db"/>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Dc"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR06221" sboTerm="SBO:0000185" id="MAR06221" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -319205,31 +317457,6 @@
           <speciesReference species="MAM02418e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR06252" sboTerm="SBO:0000185" id="MAR06252" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12883891;PMID:12856180;PMID:11023036;PMID:1554704;PMID:18021224;PMID:4553030;PMID:793184;PMID:8725559;PMID:8781017;PMID:12739169</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR06252">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106235"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00591c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00591e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR06253" sboTerm="SBO:0000185" id="MAR06253" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -338246,35 +336473,6 @@
           <fbc:geneProductRef fbc:geneProduct="Acbp1"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR07758" sboTerm="SBO:0000185" id="MAR07758" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR07758">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_7758"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01514c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039i" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01514m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Acbp1"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR07760" sboTerm="SBO:0000185" id="MAR07760" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -357781,10 +355979,14 @@
           </body>
         </notes>
         <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#meta_MAR09037">
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR09037">
               <bqbiol:is>
-                <rdf:Bag/>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EX_phyt_e"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR98853"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/EX_phyt[e]"/>
+                </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
@@ -367215,44 +365417,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00032" sboTerm="SBO:0000176" id="MAR00032" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00032">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_0032"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02392c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00240c" stoichiometry="0.19" constant="true"/>
-          <speciesReference species="MAM00511c" stoichiometry="0.0014" constant="true"/>
-          <speciesReference species="MAM00560c" stoichiometry="0.0024" constant="true"/>
-          <speciesReference species="MAM00656c" stoichiometry="0.0006" constant="true"/>
-          <speciesReference species="MAM01450c" stoichiometry="0.005" constant="true"/>
-          <speciesReference species="MAM01451c" stoichiometry="0.34" constant="true"/>
-          <speciesReference species="MAM02629c" stoichiometry="0.0008" constant="true"/>
-          <speciesReference species="MAM02684c" stoichiometry="0.0092" constant="true"/>
-          <speciesReference species="MAM02685c" stoichiometry="0.0034" constant="true"/>
-          <speciesReference species="MAM02750c" stoichiometry="0.0016" constant="true"/>
-          <speciesReference species="MAM02808c" stoichiometry="0.0002" constant="true"/>
-          <speciesReference species="MAM02908c" stoichiometry="0.0004" constant="true"/>
-          <speciesReference species="MAM02958c" stoichiometry="0.44" constant="true"/>
-          <speciesReference species="MAM10005c" stoichiometry="0.005" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR00021" sboTerm="SBO:0000629" id="MAR00021" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB2N0">
+      <reaction metaid="MAR00021" sboTerm="SBO:0000629" id="MAR00021" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -367528,7 +365693,7 @@
           <speciesReference species="MAM00005c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00013c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00014x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM00029c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00028c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00254c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00254m" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00254x" stoichiometry="1" constant="true"/>
@@ -367724,7 +365889,6 @@
           <speciesReference species="MAM00660c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00660r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00747r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM00759c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00828r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00830c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00925c" stoichiometry="1" constant="true"/>
@@ -367743,6 +365907,7 @@
           <speciesReference species="MAM01001r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01011c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01012c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01314c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01792r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01794r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02469c" stoichiometry="1" constant="true"/>
@@ -367840,37 +366005,6 @@
           <speciesReference species="MAM02552m" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR00042" sboTerm="SBO:0000176" id="MAR00042" name="3-Hydroxyisobutyryl Coenzyme A Hydrolase, Mitochondrial" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:8824301</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00042">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.2.4"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/3HBCOAHLm"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR94891"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/3HBCOAHLm"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02040m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03226m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00784m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01597m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR00043" sboTerm="SBO:0000176" id="MAR00043" name="3-Hydroxyisobutyryl-Coenzyme A Hydrolase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -368351,37 +366485,6 @@
           <fbc:geneProductRef fbc:geneProduct="VAChT"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00059" sboTerm="SBO:0000176" id="MAR00059" name="Acyl-Coenzyme A Oxidase 2, Branched Chain" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11181649</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00059">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ACOX22x"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95389"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/ACOX22x"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00755x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="0.5" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00037x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR00060" sboTerm="SBO:0000185" id="MAR00060" name="O-Acetylcarnintine Transport into Mitochondria via Diffusion" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -369428,41 +367531,6 @@
           <fbc:geneProductRef fbc:geneProduct="CG14694"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00096" sboTerm="SBO:0000176" id="MAR00096" name="Beta-Ureidopropionase (D-3-Amino-Isobutanoate Forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11508704;PMID:5773299</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00096">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.5.1.6"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/BUP2"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96346"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/BUP2"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00922c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039c" stoichiometry="2" constant="true"/>
-          <speciesReference species="MAM02040c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01596c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01633c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02579c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="pyd3"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR00097" sboTerm="SBO:0000185" id="MAR00097" name="Butyrate Mitochondrial Transport via Proton Symport, Reversible" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -371446,12 +369514,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01742x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00558x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -372140,6 +370208,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EX_dlnlcg_e"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR98420"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/EX_CE2516[e]"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/EX_dlnlcg[e]"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -372702,29 +370771,6 @@
           <speciesReference species="MAM02715e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="MAR00659" sboTerm="SBO:0000627" id="MAR00659" name="Exchange of Phytanic Acid" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00659">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EX_phyt_e"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR98853"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/EX_phyt[e]"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03884e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-      </reaction>
       <reaction metaid="MAR00661" sboTerm="SBO:0000627" id="MAR00661" name="Exchange of Phosphatidylserine (Homo Sapiens)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -373627,15 +371673,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="4" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="4" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="4" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="4" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="4" constant="true"/>
           <speciesReference species="MAM02678x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="4" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="4" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="4" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="4" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="4" constant="true"/>
           <speciesReference species="MAM02644x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -373834,15 +371880,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02941x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02678x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -374165,15 +372211,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="5" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM01934x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="5" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="5" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="2" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="5" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="5" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="5" constant="true"/>
           <speciesReference species="MAM02644x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -374250,15 +372296,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="5" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="5" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="5" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00108x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="5" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="5" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="5" constant="true"/>
           <speciesReference species="MAM02644x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -374336,14 +372382,14 @@
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01773x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02941x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -374624,16 +372670,16 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00119x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01364x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -374710,14 +372756,14 @@
         <listOfReactants>
           <speciesReference species="MAM00093x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00103x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -374835,16 +372881,16 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="2" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="2" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02971x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM01773x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="2" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="2" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -374880,14 +372926,14 @@
         <listOfReactants>
           <speciesReference species="MAM00025x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="3" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="3" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="3" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="3" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="3" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="3" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="3" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="3" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="3" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="3" constant="true"/>
           <speciesReference species="MAM02647x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -374924,14 +372970,14 @@
         <listOfReactants>
           <speciesReference species="MAM00131x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00119x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -374968,14 +373014,14 @@
         <listOfReactants>
           <speciesReference species="MAM00134x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00121x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -375012,15 +373058,15 @@
         <listOfReactants>
           <speciesReference species="MAM00110x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00093x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -375056,15 +373102,15 @@
         <listOfReactants>
           <speciesReference species="MAM00113x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00095x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -375099,15 +373145,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02110x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02971x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -375742,7 +373788,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11385633;PMID:8549872</p>
+            <p>AUTHORS: PMID:11955283;PMID:2115809;PMID:2923620;PMID:3338458;PMID:340460;PMID:8401296;PMID:8549872;PMID:8579375;PMID:9171333;PMID:9244403;PMID:9559543;PMID:11385633</p>
           </body>
         </notes>
         <annotation>
@@ -375750,10 +373796,15 @@
             <rdf:Description rdf:about="#MAR01169">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.5.3"/>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.99.5"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G3PD2m"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00849"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR99878"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106713"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/G3PD2m"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0205"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18977"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -376805,41 +374856,6 @@
           <fbc:geneProductRef fbc:geneProduct="Mfe2"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01458" sboTerm="SBO:0000176" id="MAR01458" name="Hydroxysteroid (17-Beta) Dehydrogenase 4" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR01458">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.10.1.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HSD17B4x"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100720"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HSD17B4x"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00749x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02555x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00748x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02554x" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Mfe2"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR01461" sboTerm="SBO:0000185" id="MAR01461" name="H Transporter, Endoplasmic Reticulum" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -377910,7 +375926,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10893432;PMID:11024018;PMID:11034615;PMID:12679487;PMID:12748858;PMID:1372904;PMID:15546855;PMID:2490366;PMID:7537337;PMID:7789985;PMID:8063771;PMID:8559252;PMID:8806637;PMID:9341168</p>
+            <p>AUTHORS: PMID:10893432;PMID:11024018;PMID:11034615;PMID:12679487;PMID:12748858;PMID:1372904;PMID:15546855;PMID:2490366;PMID:7537337;PMID:7789985;PMID:8063771;PMID:8559252;PMID:8806637;PMID:9341168;PMID:22573384;PMID:26772908</p>
           </body>
         </notes>
         <annotation>
@@ -377933,7 +375949,13 @@
           <speciesReference species="MAM02519c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CG10444"/>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="Ih"/>
+            <fbc:geneProductRef fbc:geneProduct="na"/>
+            <fbc:geneProductRef fbc:geneProduct="para"/>
+            <fbc:geneProductRef fbc:geneProduct="ppk11"/>
+            <fbc:geneProductRef fbc:geneProduct="ppk22"/>
+          </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR01528" sboTerm="SBO:0000185" id="MAR01528" name="Sodium/Ammonium Proton Antiporter" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
@@ -378821,15 +376843,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="3" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="3" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="3" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM03887x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="5" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="3" constant="true"/>
           <speciesReference species="MAM02774x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM03554x" stoichiometry="1" constant="true"/>
@@ -378999,33 +377021,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01617" sboTerm="SBO:0000185" id="MAR01617" name="Fatty Acid Transport via Diffusion" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR01617">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.14.99.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PHYTt"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102660"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PHYTt"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03884e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03884c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR01618" sboTerm="SBO:0000176" id="MAR01618" name="Phosphatidylinositol 4-Phosphate 3-Kinase, Endoplasmic Reticulum" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -379915,37 +377910,6 @@
           <speciesReference species="MAM02843c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR01709" sboTerm="SBO:0000185" id="MAR01709" name="Sterol Carrier Protein 2" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:1703300</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR01709">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.5.1.10"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SCP22x"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104294"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SCP22x"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03554c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03554x" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="ScpX"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR01711" sboTerm="SBO:0000176" id="MAR01711" name="Peroxisomal Thiolase 2" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -380848,7 +378812,7 @@
           <speciesReference species="MAM03135m" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR01822" sboTerm="SBO:0000185" id="MAR01822" name="Vitamin D3 Transport from Mitochondria" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01822" sboTerm="SBO:0000185" id="MAR01822" name="Vitamin D3 Transport from Mitochondria" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -380874,32 +378838,6 @@
           <speciesReference species="MAM03142c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR01823" sboTerm="SBO:0000185" id="MAR01823" name="Vitamin D3 Transport in Mitochondria" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR01823">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/VITD3tm3"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105203"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/VITD3tm3"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03142c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03142m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR01824" sboTerm="SBO:0000185" id="MAR01824" name="27 Hydroxy Cholesterol Transport" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -381782,41 +379720,6 @@
           <fbc:geneProductRef fbc:geneProduct="Nos"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02027" sboTerm="SBO:0000176" id="MAR02027" name="L-Cysteine L-Homocysteine-Lyase (Deaminating)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10212249;PMID:629532</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02027">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.4.1.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r0193"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105313"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0193"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01628c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02040c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02042c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02579c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02819c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Cth"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR02028" sboTerm="SBO:0000176" id="MAR02028" name="Trans-Hexadec-2-Enoyl Coenzyme A Reductase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -381851,44 +379754,6 @@
           <fbc:geneProductRef fbc:geneProduct="CG16935"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02035" sboTerm="SBO:0000176" id="MAR02035" name="Palmitoyl Coenzyme A:Oxygen 2-Oxidoreductase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02035">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.3"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r0310"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0310"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02678m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03103m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00051m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03102m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-            <fbc:geneProductRef fbc:geneProduct="Acadvl"/>
-            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
-            <fbc:geneProductRef fbc:geneProduct="Egm"/>
-            <fbc:geneProductRef fbc:geneProduct="Mcad"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR02119" sboTerm="SBO:0000176" id="MAR02119" name="L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -382310,38 +380175,6 @@
           <fbc:geneProductRef fbc:geneProduct="CG7724"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02185" sboTerm="SBO:0000176" id="MAR02185" name=" (3R)-3-Hydroxytetradecanoyl-[Acyl-Carrier-Protein]:NADP+ Oxidoreductase Fatty Acid Biosynthesis" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11750882;PMID:4452359;PMID:6137188;PMID:7567999;PMID:7834997;PMID:8962082</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02185">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.85"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0701"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02130c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02554c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00905c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02555c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="FASN2"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR02186" sboTerm="SBO:0000176" id="MAR02186" name="2-Amino-4-Hydroxy-6- (Erythro-1, 2, 3-Trihydroxypropyl) Dihydropteridine Triphosphate Phosphohydrolase (Alkaline Optimum)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -383034,68 +380867,6 @@
           <speciesReference species="MAM01514c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR02276" sboTerm="SBO:0000185" id="MAR02276" name="ATP-Binding Cassette (ABC) Tcdb:3.A.1.208.2" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:14716480;PMID:15209530;PMID:15297262</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02276">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r0993"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105414"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0993"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02040c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03318c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01285c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02751c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03318e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="MRP"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR02277" sboTerm="SBO:0000185" id="MAR02277" name="Facilitated Diffusion" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:15975683</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02277">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r0994"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105415"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0994"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03318c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03318r" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR02278" sboTerm="SBO:0000185" id="MAR02278" name="Facilitated Diffusion" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -384161,8 +381932,8 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG10483"/>
             <fbc:geneProductRef fbc:geneProduct="CG7536"/>
+            <fbc:geneProductRef fbc:geneProduct="PXo"/>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -384201,6 +381972,11 @@
               <fbc:geneProductRef fbc:geneProduct="RnrL"/>
               <fbc:geneProductRef fbc:geneProduct="RnrS"/>
             </fbc:and>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="RnrL"/>
+              <fbc:geneProductRef fbc:geneProduct="RnrS"/>
+              <fbc:geneProductRef fbc:geneProduct="Trx2"/>
+            </fbc:and>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -384239,41 +382015,11 @@
               <fbc:geneProductRef fbc:geneProduct="RnrL"/>
               <fbc:geneProductRef fbc:geneProduct="RnrS"/>
             </fbc:and>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR02358" sboTerm="SBO:0000176" id="MAR02358" name="NADPH:Oxidized-Thioredoxin Oxidoreductase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:5553404;PMID:5671058</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02358">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.8.1.9"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1433"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02554m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02990m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02555m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02666m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Trxr1"/>
-            <fbc:geneProductRef fbc:geneProduct="Trxr2"/>
+            <fbc:and>
+              <fbc:geneProductRef fbc:geneProduct="RnrL"/>
+              <fbc:geneProductRef fbc:geneProduct="RnrS"/>
+              <fbc:geneProductRef fbc:geneProduct="Trx2"/>
+            </fbc:and>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -384305,216 +382051,6 @@
           <speciesReference species="MAM02990m" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR02366" sboTerm="SBO:0000176" id="MAR02366" name="Acyl-CoA Oxidase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02366">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1446"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1446"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01412m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03103m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01622m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03102m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR02367" sboTerm="SBO:0000176" id="MAR02367" name="Acyl-CoA Oxidase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02367">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1447"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1447"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02345m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03103m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00042m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03102m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR02369" sboTerm="SBO:0000176" id="MAR02369" name="Acyl-CoA Oxidase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02369">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1448"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1448"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02644m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03103m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00059m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03102m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR02370" sboTerm="SBO:0000176" id="MAR02370" name="Acyl-CoA Oxidase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02370">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1449"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1449"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02495m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03103m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00066m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03102m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR02372" sboTerm="SBO:0000176" id="MAR02372" name="Acyl-CoA Oxidase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02372">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1450"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1450"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02122m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03103m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00053m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03102m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR02373" sboTerm="SBO:0000176" id="MAR02373" name="Acyl-CoA Oxidase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02373">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1451"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1451"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01650m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03103m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00039m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03102m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-            <fbc:geneProductRef fbc:geneProduct="Acox3"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR02375" sboTerm="SBO:0000176" id="MAR02375" name="Long-Chain-Acyl Coenzyme A Dehydrogenase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -384701,121 +382237,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02390" sboTerm="SBO:0000185" id="MAR02390" name="Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.14" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11076394;PMID:11076396;PMID:14579113</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02390">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r2157"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106054"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r2157"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01980c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02046c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03318e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01980e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02046e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03318c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Da"/>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Db"/>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Dc"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR02392" sboTerm="SBO:0000185" id="MAR02392" name="Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.14" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11076394;PMID:11076396;PMID:14579113</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02392">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r2158"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106055"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r2158"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02046c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02900c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03318e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02046e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02900e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03318c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Da"/>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Db"/>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Dc"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR02394" sboTerm="SBO:0000185" id="MAR02394" name="Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.14" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11076394;PMID:11076396;PMID:14579113</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02394">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r2159"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106056"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r2159"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02046c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02901c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03318e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02046e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02901e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03318c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Da"/>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Db"/>
-            <fbc:geneProductRef fbc:geneProduct="Oatp58Dc"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR02396" sboTerm="SBO:0000185" id="MAR02396" name="Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02396" sboTerm="SBO:0000185" id="MAR02396" name="Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -384830,6 +382252,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r2236"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106133"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r2236"/>
+                  <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.60.1.5"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -384853,7 +382276,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02398" sboTerm="SBO:0000185" id="MAR02398" name="Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02398" sboTerm="SBO:0000185" id="MAR02398" name="Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -384868,6 +382291,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r2237"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106134"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r2237"/>
+                  <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.60.1.5"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -384891,7 +382315,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02400" sboTerm="SBO:0000185" id="MAR02400" name="Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02400" sboTerm="SBO:0000185" id="MAR02400" name="Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -384906,6 +382330,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r2238"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106135"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r2238"/>
+                  <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.60.1.5"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -384944,6 +382369,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r2315"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR106212"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r2315"/>
+                  <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.60.1.2"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -385998,9 +383424,9 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG17691"/>
+            <fbc:geneProductRef fbc:geneProduct="BckdhA"/>
+            <fbc:geneProductRef fbc:geneProduct="BckdhB"/>
             <fbc:geneProductRef fbc:geneProduct="CG7430"/>
-            <fbc:geneProductRef fbc:geneProduct="CG8199"/>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -386796,7 +384222,7 @@
           <speciesReference species="MAM02751n" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR02786" sboTerm="SBO:0000176" id="MAR02786" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02786" sboTerm="SBO:0000176" id="MAR02786" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -386832,7 +384258,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02802" sboTerm="SBO:0000176" id="MAR02802" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02802" sboTerm="SBO:0000176" id="MAR02802" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -386881,6 +384307,7 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RE1516X"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE1516X"/>
                 </rdf:Bag>
@@ -386916,6 +384343,7 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RE1517X"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE1517X"/>
                 </rdf:Bag>
@@ -386951,6 +384379,7 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RE1518X"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE1518X"/>
                 </rdf:Bag>
@@ -386977,7 +384406,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10407780;PMID:11356167;PMID:8973539</p>
+            <p>AUTHORS: PMID:10407780;PMID:11356167;PMID:8973539;PMID:18536048;PMID:17458872</p>
           </body>
         </notes>
         <annotation>
@@ -386987,7 +384416,9 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.13"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RE1519X"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FAOXC101C102x"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE1519X"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/FAOXC101C102x"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -389814,6 +387245,7 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE2913X"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -389848,6 +387280,7 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.99.3"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.6"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE2914X"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -390350,7 +387783,7 @@
           <speciesReference species="MAM03359m" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Ech1"/>
+          <fbc:geneProductRef fbc:geneProduct="CG9577"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR03378" sboTerm="SBO:0000176" id="MAR03378" name="Dodecenoyl Coenzyme A Isomerase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
@@ -390603,7 +388036,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03388" sboTerm="SBO:0000176" id="MAR03388" name="Phytanate- Coenzyme A Ligase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03388" sboTerm="SBO:0000176" id="MAR03388" name="Phytanate- Coenzyme A Ligase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -390635,7 +388068,7 @@
           <speciesReference species="MAM03362c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR03390" sboTerm="SBO:0000176" id="MAR03390" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03390" sboTerm="SBO:0000176" id="MAR03390" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -391517,10 +388950,10 @@
           <speciesReference species="MAM02444c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM00902c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01596c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00853c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction metaid="MAR03440" sboTerm="SBO:0000176" id="MAR03440" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -391561,36 +388994,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03441" sboTerm="SBO:0000176" id="MAR03441" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10970790</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR03441">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RE3150C"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103806"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE3150C"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00681c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02555c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02554c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03354c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR03442" sboTerm="SBO:0000176" id="MAR03442" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -391617,8 +389020,8 @@
           <speciesReference species="MAM00681r" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
+          <speciesReference species="MAM00131r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02554r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03354r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -393184,33 +390587,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03754" sboTerm="SBO:0000176" id="MAR03754" name="Enoyl Coenzyme A Hydratase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10709654</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR03754">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.17"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE3248M"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00749m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02040m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03367m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR03758" sboTerm="SBO:0000176" id="MAR03758" name="3-Hydroxyacyl Coenzyme A Dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -393242,41 +390618,6 @@
           <speciesReference species="MAM03368c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR03760" sboTerm="SBO:0000176" id="MAR03760" name="3-Hydroxyacyl Coenzyme A Dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10709654</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR03760">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.35"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE3250M"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02552m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03367m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02553m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03368m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="Mfe2"/>
-            <fbc:geneProductRef fbc:geneProduct="scu"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR03764" sboTerm="SBO:0000176" id="MAR03764" name="3-Hydroxyacyl Coenzyme A Dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -393291,6 +390632,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.35"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE3250X"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE3250M"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -393301,9 +390643,9 @@
           <speciesReference species="MAM03367x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
+          <speciesReference species="MAM00748x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03368x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:geneProductRef fbc:geneProduct="Mfe2"/>
@@ -394586,7 +391928,7 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM03325c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00684c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM03510c" stoichiometry="1" constant="true"/>
@@ -395388,11 +392730,11 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03352x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03021x" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
@@ -396460,29 +393802,6 @@
           <speciesReference species="MAM01439e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="MAR04144" sboTerm="SBO:0000627" id="MAR04144" name="Exchange of Chenodeoxycholate" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR04144">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EX_C02528_e"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR98101"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/EX_C02528[e]"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03318e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-      </reaction>
       <reaction metaid="MAR04146" sboTerm="SBO:0000627" id="MAR04146" name="Exchange of Taurolithocholate" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -398495,37 +395814,6 @@
           <fbc:geneProductRef fbc:geneProduct="whd"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR04506" sboTerm="SBO:0000176" id="MAR04506" name="Production of Dodecanoylcarnitine" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12828998;PMID:9498103;PMID:3955080</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR04506">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/C120CPT1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/C120CPT1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02345c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02348c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03540c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="whd"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR04508" sboTerm="SBO:0000176" id="MAR04508" name="Production of Dodecenoylcarnitine" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -400513,7 +397801,7 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM03540e" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01729e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
       <reaction metaid="MAR04925" sboTerm="SBO:0000627" id="MAR04925" name="Exchange of Decadienoyl Carnitine" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
@@ -400672,37 +397960,6 @@
           <speciesReference species="MAM03980e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="MAR04966" sboTerm="SBO:0000176" id="MAR04966" name="Fatty Acid Beta Oxidation (C10:1-&gt;C10:2), Peroxisomal" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:18536048;PMID:17458872</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR04966">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FAOXC101C102x"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/FAOXC101C102x"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00980x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00678x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR04967" sboTerm="SBO:0000176" id="MAR04967" name="Fatty Acid Beta Oxidation (C10:1-&gt;C8), Mitochondrial" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -400827,11 +398084,11 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03542x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03545x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -401073,14 +398330,14 @@
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01650x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02644x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -401112,15 +398369,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03924x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03922x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -401152,14 +398409,14 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM04004x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02774x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03554x" stoichiometry="1" constant="true"/>
@@ -401587,16 +398844,16 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02345x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01650x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -401662,15 +398919,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03491x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03924x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -401794,14 +399051,14 @@
         <listOfReactants>
           <speciesReference species="MAM00948x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM04004x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -401902,15 +399159,15 @@
         <listOfReactants>
           <speciesReference species="MAM01141x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00088x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -402004,15 +399261,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03978x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03203x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -402107,15 +399364,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03288x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03211x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -402183,15 +399440,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02495x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02345x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -402252,15 +399509,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03492x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03491x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -402292,15 +399549,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03887x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00948x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02774x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -402465,15 +399722,15 @@
         <listOfReactants>
           <speciesReference species="MAM01191x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01141x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -402695,11 +399952,11 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03274x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03653x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -402918,11 +400175,11 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03273x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03656x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -403048,15 +400305,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02678x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02495x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -403117,15 +400374,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03655x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03492x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -403259,16 +400516,16 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03789x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01191x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -403560,15 +400817,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00108x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03273x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -403756,15 +401013,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03567x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03789x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -403829,11 +401086,11 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03571x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03570x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -403930,15 +401187,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03555x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03567x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -404068,10 +401325,10 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM00093x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03557x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -404258,15 +401515,15 @@
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01725x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01773x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -404298,14 +401555,14 @@
         <listOfReactants>
           <speciesReference species="MAM00025x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03555x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -404337,16 +401594,16 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02971x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01725x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -404763,16 +402020,16 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02122x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01412x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
@@ -404803,15 +402060,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03409x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02944x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -404925,15 +402182,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03794x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03659x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -405006,15 +402263,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02644x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02122x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -405046,15 +402303,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03922x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03409x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -407236,8 +404493,10 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLNATB0tc"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLNB0AT3tc"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100248"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/GLNATB0tc"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/GLNB0AT3tc"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -413259,38 +410518,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR09887" sboTerm="SBO:0000185" id="MAR09887" name="Glutamine Transport by B0At3" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR09887">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLNB0AT3tc"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/GLNB0AT3tc"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01442e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01975e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02519e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01442c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01975c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02519c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CG43066"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR09888" sboTerm="SBO:0000185" id="MAR09888" name="Glutamate Transport by B0At3" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -417861,36 +415088,6 @@
           <speciesReference species="MAM01172e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR10164" sboTerm="SBO:0000185" id="MAR10164" name="Transport of (8Z, 11Z, 14Z)-Eicosatrienoic Acid, Active Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:24653705;PMID:9831619;PMID:5555776;PMID:23104810</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR10164">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/CE2516t"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02040c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03332c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01285c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02751c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03332e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR10165" sboTerm="SBO:0000185" id="MAR10165" name="Transport of 15-Hydroxy- (8Z, 11Z, 13E)-Eicosatrienoate, Active Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -424219,27 +421416,6 @@
           <speciesReference species="MAM01584e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="MAR10433" sboTerm="SBO:0000627" id="MAR10433" name="Exchangefor (8Z, 11Z, 14Z)-Eicosatrienoic Acid" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR10433">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/EX_CE2516[e]"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03332e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-      </reaction>
       <reaction metaid="MAR10434" sboTerm="SBO:0000627" id="MAR10434" name="Exchange of Laurate" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -424504,38 +421680,6 @@
           <speciesReference species="MAM03398m" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR10447" sboTerm="SBO:0000176" id="MAR10447" name="Formation of Sulfochenodeoxycholate" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:19131563;PMID:16949895</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR10447">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HC02220c"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC02220c"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02682c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03318c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02681c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02950c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="St2"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR10448" sboTerm="SBO:0000176" id="MAR10448" name="Formation of 7-Ketolithocholate" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -424556,10 +421700,10 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01435c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02555c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02630c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03318c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM02040c" stoichiometry="2" constant="true"/>
@@ -425072,7 +422216,7 @@
           <speciesReference species="MAM03836c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR10466" sboTerm="SBO:0000185" id="MAR10466" name="Secretion of P-Cresol Sulfate" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR10466" sboTerm="SBO:0000185" id="MAR10466" name="Secretion of P-Cresol Sulfate" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -425086,6 +422230,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PCSsec"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PCSsec"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PCSup"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -425098,36 +422243,11 @@
           <speciesReference species="MAM03837e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR10467" sboTerm="SBO:0000185" id="MAR10467" name="Uptake of P-Cresol Sulfate" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR10468" sboTerm="SBO:0000185" id="MAR10468" name="3-Hydroxycinnamic Acid Uptake" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:21343587</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR10467">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PCSup"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03837e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03837c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR10468" sboTerm="SBO:0000185" id="MAR10468" name="3-Hydroxycinnamic Acid Uptake" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12904817</p>
+            <p>AUTHORS: PMID:12904817;PMID:12663291</p>
           </body>
         </notes>
         <annotation>
@@ -425136,6 +422256,7 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/3HCINNMup"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/3HCINNMsec"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -425148,32 +422269,7 @@
           <speciesReference species="MAM03215c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR10469" sboTerm="SBO:0000185" id="MAR10469" name="3-Hydroxycinanmic Acid Secretion" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12904817</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR10469">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/3HCINNMsec"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03215c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03215e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR10470" sboTerm="SBO:0000185" id="MAR10470" name="3-Hydroxyphenylpropionic Acid Uptake" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR10470" sboTerm="SBO:0000176" id="MAR10470" name="3-Hydroxyphenylpropionic Acid Uptake" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -425186,30 +422282,6 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/3HPPAup"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03231e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03231c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR10471" sboTerm="SBO:0000185" id="MAR10471" name="3-Hydroxyphenylpropionic Acid Secretion" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12904817;PMID:12663291</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR10471">
-              <bqbiol:is>
-                <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/3HPPAsec"/>
                 </rdf:Bag>
               </bqbiol:is>
@@ -425217,10 +422289,10 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM03231c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM03231e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM03231e" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM03232c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction metaid="MAR10472" sboTerm="SBO:0000627" id="MAR10472" name="3-Hydroxycinnamic Acid Exchange" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
@@ -447025,10 +444097,10 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM03540e" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01729e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM03540c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01729c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction metaid="MAR11267" sboTerm="SBO:0000185" id="MAR11267" name="Transport of Dodecenoyl Carnitine" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
@@ -453667,19 +450739,19 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03409x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03213x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
             <fbc:and>
               <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-              <fbc:geneProductRef fbc:geneProduct="Ech1"/>
+              <fbc:geneProductRef fbc:geneProduct="CG9577"/>
             </fbc:and>
             <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
           </fbc:or>
@@ -453813,19 +450885,19 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03924x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03259x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
             <fbc:and>
               <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-              <fbc:geneProductRef fbc:geneProduct="Ech1"/>
+              <fbc:geneProductRef fbc:geneProduct="CG9577"/>
             </fbc:and>
             <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
           </fbc:or>
@@ -453956,19 +451028,19 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03922x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03261x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
             <fbc:and>
               <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
-              <fbc:geneProductRef fbc:geneProduct="Ech1"/>
+              <fbc:geneProductRef fbc:geneProduct="CG9577"/>
             </fbc:and>
             <fbc:geneProductRef fbc:geneProduct="ACOX1"/>
           </fbc:or>
@@ -455178,11 +452250,11 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11583" sboTerm="SBO:0000185" id="MAR11583" name="Transport of 1-Phosphatidyl-1D-Myo-Inositol" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11583" sboTerm="SBO:0000185" id="MAR11583" name="Transport of 1-Phosphatidyl-1D-Myo-Inositol" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:8145081</p>
+            <p>AUTHORS: PMID:8145081;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -455190,8 +452262,11 @@
             <rdf:Description rdf:about="#MAR11583">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.44"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.1"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PAIL_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PAIL_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PAIL_hs_t1e"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -455204,11 +452279,11 @@
           <speciesReference species="MAM02750e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11584" sboTerm="SBO:0000185" id="MAR11584" name="Transport of 1-Palmitoylglycerophosphoinositol" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11584" sboTerm="SBO:0000185" id="MAR11584" name="Transport of 1-Palmitoylglycerophosphoinositol" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:8145081</p>
+            <p>AUTHORS: PMID:8145081;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -455218,6 +452293,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PAILPALM_HSSECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PAILPALM_HSSECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PAILPALM_HSt1e"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -455230,11 +452306,11 @@
           <speciesReference species="MAM03803e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11585" sboTerm="SBO:0000185" id="MAR11585" name="Transport of 1-Arachidonoylglycerophosphoinositol" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11585" sboTerm="SBO:0000185" id="MAR11585" name="Transport of 1-Arachidonoylglycerophosphoinositol" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:8145081</p>
+            <p>AUTHORS: PMID:8145081;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -455244,6 +452320,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PAILR_HSSECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PAILR_HSSECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PAILR_HSt1e"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -455256,11 +452333,11 @@
           <speciesReference species="MAM03802e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11586" sboTerm="SBO:0000185" id="MAR11586" name="Transport of 1-Stearoylglycerophosphoinositol" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11586" sboTerm="SBO:0000185" id="MAR11586" name="Transport of 1-Stearoylglycerophosphoinositol" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:8145081</p>
+            <p>AUTHORS: PMID:8145081;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -455269,6 +452346,7 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PAILSTE_HSSECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PAILSTE_HSt1e"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -456956,10 +454034,11 @@
           <speciesReference species="MAM02908e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11630" sboTerm="SBO:0000185" id="MAR11630" name="Transport of Sphingomyelin (D18:0/24:1)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11630" sboTerm="SBO:0000185" id="MAR11630" name="Transport of Sphingomyelin (D18:0/24:1)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -456967,8 +454046,10 @@
             <rdf:Description rdf:about="#MAR11630">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.1"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SPHMYLN180241_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN180241_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN180241_hs_t1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -456981,10 +454062,11 @@
           <speciesReference species="MAM03936e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11631" sboTerm="SBO:0000185" id="MAR11631" name="Transport of Sphingomyelin (D18:1/14:0)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11631" sboTerm="SBO:0000185" id="MAR11631" name="Transport of Sphingomyelin (D18:1/14:0)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -456992,8 +454074,10 @@
             <rdf:Description rdf:about="#MAR11631">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.1"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SPHMYLN18114_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18114_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18114_hs_t1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -457006,10 +454090,11 @@
           <speciesReference species="MAM03937e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11632" sboTerm="SBO:0000185" id="MAR11632" name="Transport of Sphingomyelin (D18:1/15:0)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11632" sboTerm="SBO:0000185" id="MAR11632" name="Transport of Sphingomyelin (D18:1/15:0)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -457017,8 +454102,10 @@
             <rdf:Description rdf:about="#MAR11632">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.1"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SPHMYLN18115_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18115_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18115_hs_t1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -457031,10 +454118,11 @@
           <speciesReference species="MAM03938e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11633" sboTerm="SBO:0000185" id="MAR11633" name="Transport of Sphingomyelin (D18:1/16:0)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11633" sboTerm="SBO:0000185" id="MAR11633" name="Transport of Sphingomyelin (D18:1/16:0)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -457042,8 +454130,10 @@
             <rdf:Description rdf:about="#MAR11633">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.1"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SPHMYLN18116_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18116_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18116_hs_t1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -457056,10 +454146,11 @@
           <speciesReference species="MAM03940e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11634" sboTerm="SBO:0000185" id="MAR11634" name="Transport of Sphingomyelin (D18:1/16:1)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11634" sboTerm="SBO:0000185" id="MAR11634" name="Transport of Sphingomyelin (D18:1/16:1)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -457067,8 +454158,10 @@
             <rdf:Description rdf:about="#MAR11634">
               <bqbiol:is>
                 <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.1"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SPHMYLN181161_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN181161_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN181161_hs_t1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -457081,10 +454174,11 @@
           <speciesReference species="MAM03939e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11635" sboTerm="SBO:0000185" id="MAR11635" name="Transport of Sphingomyelin (D18:1/17:0)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11635" sboTerm="SBO:0000185" id="MAR11635" name="Transport of Sphingomyelin (D18:1/17:0)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -457093,8 +454187,10 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.1"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SPHMYLN18117_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18117_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18117_hs_t1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -457107,10 +454203,11 @@
           <speciesReference species="MAM03941e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11636" sboTerm="SBO:0000185" id="MAR11636" name="Transport of Sphingomyelin (D18:1/18:0)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11636" sboTerm="SBO:0000185" id="MAR11636" name="Transport of Sphingomyelin (D18:1/18:0)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -457120,6 +454217,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SPHMYLN18118_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18118_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18118_hs_t1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -457132,10 +454230,11 @@
           <speciesReference species="MAM03943e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11637" sboTerm="SBO:0000185" id="MAR11637" name="Transport of Sphingomyelin (D18:1/18:1)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11637" sboTerm="SBO:0000185" id="MAR11637" name="Transport of Sphingomyelin (D18:1/18:1)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -457145,6 +454244,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SPHMYLN181181_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN181181_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN181181_hs_t1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -457157,10 +454257,11 @@
           <speciesReference species="MAM03942e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11638" sboTerm="SBO:0000185" id="MAR11638" name="Transport of Sphingomyelin (D18:1/20:0)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11638" sboTerm="SBO:0000185" id="MAR11638" name="Transport of Sphingomyelin (D18:1/20:0)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -457170,6 +454271,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SPHMYLN18120_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18120_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18120_hs_t1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -457182,10 +454284,11 @@
           <speciesReference species="MAM03945e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11639" sboTerm="SBO:0000185" id="MAR11639" name="Transport of Sphingomyelin (D18:1/20:1)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11639" sboTerm="SBO:0000185" id="MAR11639" name="Transport of Sphingomyelin (D18:1/20:1)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -457195,6 +454298,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SPHMYLN181201_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN181201_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN181201_hs_t1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -457207,10 +454311,11 @@
           <speciesReference species="MAM03944e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11640" sboTerm="SBO:0000185" id="MAR11640" name="Transport of Sphingomyelin (D18:1/21:0)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11640" sboTerm="SBO:0000185" id="MAR11640" name="Transport of Sphingomyelin (D18:1/21:0)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -457220,6 +454325,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SPHMYLN18121_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18121_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18121_hs_t1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -457232,10 +454338,11 @@
           <speciesReference species="MAM03946e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11641" sboTerm="SBO:0000185" id="MAR11641" name="Transport of Sphingomyelin (D18:1/22:0)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11641" sboTerm="SBO:0000185" id="MAR11641" name="Transport of Sphingomyelin (D18:1/22:0)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -457245,6 +454352,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SPHMYLN18122_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18122_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18122_hs_t1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -457257,10 +454365,11 @@
           <speciesReference species="MAM03948e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11642" sboTerm="SBO:0000185" id="MAR11642" name="Transport of Sphingomyelin (D18:1/22:1)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11642" sboTerm="SBO:0000185" id="MAR11642" name="Transport of Sphingomyelin (D18:1/22:1)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -457271,6 +454380,7 @@
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.13"/>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SPHMYLN181221_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN181221_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN181221_hs_t1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -457283,10 +454393,11 @@
           <speciesReference species="MAM03947e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11643" sboTerm="SBO:0000185" id="MAR11643" name="Transport of Sphingomyelin (D18:1/23:0)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11643" sboTerm="SBO:0000185" id="MAR11643" name="Transport of Sphingomyelin (D18:1/23:0)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -457296,6 +454407,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SPHMYLN18123_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18123_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18123_hs_t1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -457308,10 +454420,11 @@
           <speciesReference species="MAM03949e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11644" sboTerm="SBO:0000185" id="MAR11644" name="Transport of Sphingomyelin (D18:0/24:0)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11644" sboTerm="SBO:0000185" id="MAR11644" name="Transport of Sphingomyelin (D18:0/24:0)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -457321,6 +454434,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SPHMYLN1824_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN1824_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN1824_hs_t1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -457333,10 +454447,11 @@
           <speciesReference species="MAM03950e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11645" sboTerm="SBO:0000185" id="MAR11645" name="Transport of Sphingomyelin (D18:0/25:0)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11645" sboTerm="SBO:0000185" id="MAR11645" name="Transport of Sphingomyelin (D18:0/25:0)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
           </body>
         </notes>
         <annotation>
@@ -457346,6 +454461,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SPHMYLN1825_hs_SECt"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN1825_hs_SECt"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN1825_hs_t1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -457458,108 +454574,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11649" sboTerm="SBO:0000185" id="MAR11649" name="Transport of 1-Phosphatidyl-1D-Myo-Inositol, Vescicular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11649">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.44"/>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PAIL_hs_t1e"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02750e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02750c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR11650" sboTerm="SBO:0000185" id="MAR11650" name="Transport of 1-Arachidonoylglycerophosphoinositol, Vescicular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11650">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PAILR_HSt1e"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03802e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03802c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR11651" sboTerm="SBO:0000185" id="MAR11651" name="Transport of 1-Palmitoylglycerophosphoinositol, Vescicular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11651">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PAILPALM_HSt1e"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03803e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03803c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR11652" sboTerm="SBO:0000185" id="MAR11652" name="Transport of 1-Stearoylglycerophosphoinositol, Vescicular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11652">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PAILSTE_HSt1e"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03804e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03804c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11653" sboTerm="SBO:0000185" id="MAR11653" name="Transport of 2-Linoleoylglycerophosphocholine, Vescicular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -458783,32 +455797,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11697" sboTerm="SBO:0000185" id="MAR11697" name="Transport of Sphingomyelin (D18:0/24:1) Vescicular Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11697">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN180241_hs_t1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03936e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03936c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11698" sboTerm="SBO:0000185" id="MAR11698" name="Transport of Sphingomyelin (D18:1/14:0), Active Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -458846,32 +455834,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11699" sboTerm="SBO:0000185" id="MAR11699" name="Transport of Sphingomyelin (D18:1/14:0), Vescicular Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11699">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18114_hs_t1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03937e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03937c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11700" sboTerm="SBO:0000185" id="MAR11700" name="Transport of Sphingomyelin (D18:1/15:0), Active Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -458909,32 +455871,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11701" sboTerm="SBO:0000185" id="MAR11701" name="Transport of Sphingomyelin (D18:1/15:0), Vescicular Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11701">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18115_hs_t1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03938e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03938c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11702" sboTerm="SBO:0000185" id="MAR11702" name="Transport of Sphingomyelin (D18:1/16:0), Active Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -458972,32 +455908,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11703" sboTerm="SBO:0000185" id="MAR11703" name="Transport of Sphingomyelin (D18:1/16:0), Vescicular Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11703">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18116_hs_t1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03940e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03940c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11704" sboTerm="SBO:0000185" id="MAR11704" name="Transport of Sphingomyelin (D18:1/16:1), Active Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -459035,32 +455945,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11705" sboTerm="SBO:0000185" id="MAR11705" name="Transport of Sphingomyelin (D18:1/16:1), Vescicular Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11705">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN181161_hs_t1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03939e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03939c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11706" sboTerm="SBO:0000185" id="MAR11706" name="Transport of Sphingomyelin (D18:1/17:0), Active" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -459098,32 +455982,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11707" sboTerm="SBO:0000185" id="MAR11707" name="Transport of Sphingomyelin (D18:1/17:0), Vescicular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11707">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18117_hs_t1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03941e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03941c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11708" sboTerm="SBO:0000185" id="MAR11708" name="Transport of Sphingomyelin (D18:1/18:0), Active" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -459161,31 +456019,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11709" sboTerm="SBO:0000185" id="MAR11709" name="Transport of Sphingomyelin (D18:1/18:0), Vescicular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11709">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18118_hs_t1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03943e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03943c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11710" sboTerm="SBO:0000185" id="MAR11710" name="Transport of Sphingomyelin (D18:1/18:1), Active" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -459223,31 +456056,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11711" sboTerm="SBO:0000185" id="MAR11711" name="Transport of Sphingomyelin (D18:1/18:1), Vescicular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11711">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN181181_hs_t1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03942e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03942c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11712" sboTerm="SBO:0000185" id="MAR11712" name="Transport of Sphingomyelin (D18:1/20:0), Active" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -459285,31 +456093,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11713" sboTerm="SBO:0000185" id="MAR11713" name="Transport of Sphingomyelin (D18:1/20:0), Vescicular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11713">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18120_hs_t1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03945e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03945c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11714" sboTerm="SBO:0000185" id="MAR11714" name="Transport of Sphingomyelin (D18:1/20:1), Active" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -459347,31 +456130,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11715" sboTerm="SBO:0000185" id="MAR11715" name="Transport of Sphingomyelin (D18:1/20:1), Vescicular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11715">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN181201_hs_t1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03944e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03944c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11716" sboTerm="SBO:0000185" id="MAR11716" name="Transport of Sphingomyelin (D18:1/21:0), Active" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -459409,31 +456167,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11717" sboTerm="SBO:0000185" id="MAR11717" name="Transport of Sphingomyelin (D18:1/21:0), Vescicular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11717">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18121_hs_t1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03946e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03946c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11718" sboTerm="SBO:0000185" id="MAR11718" name="Transport of Sphingomyelin (D18:1/22:0), Active Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -459471,31 +456204,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11719" sboTerm="SBO:0000185" id="MAR11719" name="Transport of Sphingomyelin (D18:1/22:0), Vescicular Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11719">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18122_hs_t1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03948e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03948c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11720" sboTerm="SBO:0000185" id="MAR11720" name="Transport of Sphingomyelin (D18:1/22:1), Active" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -459533,31 +456241,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11721" sboTerm="SBO:0000185" id="MAR11721" name="Transport of Sphingomyelin (D18:1/22:1), Vescicular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11721">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN181221_hs_t1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03947e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03947c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11722" sboTerm="SBO:0000185" id="MAR11722" name="Transport of Sphingomyelin (D18:1/23:0), Active" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -459595,31 +456278,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11723" sboTerm="SBO:0000185" id="MAR11723" name="Transport of Sphingomyelin (D18:1/23:0), Vescicular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11723">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN18123_hs_t1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03949e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03949c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11724" sboTerm="SBO:0000185" id="MAR11724" name="Transport of Sphingomyelin (D18:0/24:0), Active Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -459657,31 +456315,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11725" sboTerm="SBO:0000185" id="MAR11725" name="Transport of Sphingomyelin (D18:0/24:0), Vescicular Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11725">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN1824_hs_t1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03950e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03950c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11726" sboTerm="SBO:0000185" id="MAR11726" name="Transport of Sphingomyelin (D18:0/25:0), Active Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -459719,32 +456352,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR11727" sboTerm="SBO:0000185" id="MAR11727" name="Transport of Sphingomyelin (D18:0/25:0), Vescicular Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11581500;PMID:10856719</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11727">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/SPHMYLN1825_hs_t1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03951e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03951c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR11728" sboTerm="SBO:0000185" id="MAR11728" name="Transport of 2-Hydroxy-Isocaproate, Extracellular, Uptake" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11728" sboTerm="SBO:0000185" id="MAR11728" name="Transport of 2-Hydroxy-Isocaproate, Extracellular, Uptake" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -459757,6 +456365,7 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.44"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/2HXIC_Lt1e"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/2HXIC_Lt2e"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -459769,30 +456378,6 @@
           <speciesReference species="MAM03187c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11729" sboTerm="SBO:0000185" id="MAR11729" name="Transport of 2-Hydroxy-Isocaproate, Extracellular, Secretion" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11729">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/2HXIC_Lt2e"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03187c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03187e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11730" sboTerm="SBO:0000627" id="MAR11730" name="Exchange of 2-Hydroxy-Isocaproate" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -466542,7 +463127,7 @@
           <speciesReference species="MAM03647e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="MAR11986" sboTerm="SBO:0000185" id="MAR11986" name="Transport of Apo B, Extracellular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11986" sboTerm="SBO:0000185" id="MAR11986" name="Transport of Apo B, Extracellular" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -466554,6 +463139,7 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC00005te"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC00005t1e"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -466588,31 +463174,7 @@
           <speciesReference species="MAM01351e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="MAR11988" sboTerm="SBO:0000185" id="MAR11988" name="Transport of Apo B, Extracellular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11988">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC00005t1e"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01351e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01351c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR11989" sboTerm="SBO:0000185" id="MAR11989" name="Transport of Apo C1, Extracellular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11989" sboTerm="SBO:0000185" id="MAR11989" name="Transport of Apo C1, Extracellular" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -466624,6 +463186,7 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC00006te"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC00006t1e"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -466658,31 +463221,7 @@
           <speciesReference species="MAM01353e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="MAR11991" sboTerm="SBO:0000185" id="MAR11991" name="Transport of Apo C1, Extracellular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11991">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC00006t1e"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01353e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01353c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR11992" sboTerm="SBO:0000185" id="MAR11992" name="Transport of Apo C2, Extracellular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11992" sboTerm="SBO:0000185" id="MAR11992" name="Transport of Apo C2, Extracellular" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -466694,6 +463233,7 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC00007te"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC00007t1e"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -466728,31 +463268,7 @@
           <speciesReference species="MAM01354e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="MAR11994" sboTerm="SBO:0000185" id="MAR11994" name="Transport of Apo C2, Extracellular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11994">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC00007t1e"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01354e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01354c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR11995" sboTerm="SBO:0000185" id="MAR11995" name="Transport of Apo C3, Extracellular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11995" sboTerm="SBO:0000185" id="MAR11995" name="Transport of Apo C3, Extracellular" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -466764,6 +463280,7 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC00008te"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC00008t1e"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -466798,31 +463315,7 @@
           <speciesReference species="MAM01355e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="MAR11997" sboTerm="SBO:0000185" id="MAR11997" name="Transport of Apo C3, Extracellular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11997">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC00008t1e"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01355e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01355c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR11998" sboTerm="SBO:0000185" id="MAR11998" name="Transport of Apo E, Extracellular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR11998" sboTerm="SBO:0000185" id="MAR11998" name="Transport of Apo E, Extracellular" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -466834,6 +463327,7 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC00009te"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC00009t1e"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -466868,30 +463362,6 @@
           <speciesReference species="MAM01359e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="MAR12000" sboTerm="SBO:0000185" id="MAR12000" name="Transport of Apo E, Extracellular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR12000">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HC00009t1e"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01359e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01359c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR12001" sboTerm="SBO:0000176" id="MAR12001" name="Dopamine 4-O-Sulfotransferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -467212,7 +463682,10 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DOPACHRMDC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03674"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR108330"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/DOPACHRMDC"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_9733"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -470262,10 +466735,10 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01435c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02555c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02630c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03318c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM02040c" stoichiometry="2" constant="true"/>
@@ -471269,8 +467742,8 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01435c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03109c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03318c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM03106c" stoichiometry="1" constant="true"/>
@@ -471310,8 +467783,8 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01435r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03109r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03318r" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM03106r" stoichiometry="1" constant="true"/>
@@ -471413,8 +467886,8 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01435c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03109c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03318c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM03106c" stoichiometry="1" constant="true"/>
@@ -471455,8 +467928,8 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01435r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03109r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03318r" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM03106r" stoichiometry="1" constant="true"/>
@@ -471594,10 +468067,10 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM01435c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02555c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02630c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03318c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM02040c" stoichiometry="1" constant="true"/>
@@ -477542,15 +474015,15 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="2" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="2" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03236x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="2" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="2" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM03238x" stoichiometry="1" constant="true"/>
         </listOfProducts>
@@ -489529,16 +486002,16 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01597x" stoichiometry="4" constant="true"/>
+          <speciesReference species="MAM01802x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02040x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02552x" stoichiometry="4" constant="true"/>
           <speciesReference species="MAM02555x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM03580x" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01261x" stoichiometry="4" constant="true"/>
+          <speciesReference species="MAM01803x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02039x" stoichiometry="3" constant="true"/>
-          <speciesReference species="MAM02041x" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02553x" stoichiometry="4" constant="true"/>
           <speciesReference species="MAM02554x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03893x" stoichiometry="1" constant="true"/>
@@ -496013,27 +492486,6 @@
           <speciesReference species="MAM03153e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="MAR13064" sboTerm="SBO:0000627" id="MAR13064" name="EX_M01268[e]" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR13064">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/EX_M01268[e]"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01268e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-      </reaction>
       <reaction metaid="MAR13065" sboTerm="SBO:0000627" id="MAR13065" name="EX_HC02080[e]" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -496479,25 +492931,6 @@
           <speciesReference species="MAM03971e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="MAR10025" sboTerm="SBO:0000627" id="MAR10025" name="Exchange of 20-hydroxy-arachidonate" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#meta_MAR10025">
-              <bqbiol:is>
-                <rdf:Bag/>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00591e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-      </reaction>
       <reaction metaid="MAR10026" sboTerm="SBO:0000627" id="MAR10026" name="Exchange of chenodiol" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -497831,7 +494264,7 @@
           <speciesReference species="MAM10012c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR13082" sboTerm="SBO:0000629" id="MAR13082" name="Generic human cell biomass reaction" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR13082" sboTerm="SBO:0000629" id="MAR13082" name="Generic human cell biomass reaction" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB2N0">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -499659,45 +496092,6 @@
           <fbc:geneProductRef fbc:geneProduct="Fdh"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR20002" sboTerm="SBO:0000176" id="MAR20002" name="MAR20002" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR20002">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.105"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HMR_6633"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RDH1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HMR_6633"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_RDH1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_TRETINOLOR1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TRETINOLOR1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02124"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR189842"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/21284"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02552c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02834c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02553c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02832c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Fdh"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR20003" sboTerm="SBO:0000176" id="MAR20003" name="MAR20003" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -500026,43 +496420,6 @@
           <speciesReference species="MAM02642c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR20020" sboTerm="SBO:0000176" id="MAR20020" name="MAR20020" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR20020">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.3.9"/>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/ 3.1.3.58"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G6PP"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/G6PPer"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_G6PP"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_G6PPer"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00303"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR195425"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/16689"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01968r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02040r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01965r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02751r" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="G6P"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR20033" sboTerm="SBO:0000176" id="MAR20033" name="MAR20033" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -501074,48 +497431,6 @@
           <speciesReference species="MAM20057c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR20066" sboTerm="SBO:0000176" id="MAR20066" name="MAR20066" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR20066">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.11.1.6"/>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/ 1.11.1.21"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CAT"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CATm"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CATp"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CATpp"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CATr"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_CAT"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_CATm"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_CATp"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_CATpp"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_CATr"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00009"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96455"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/20309"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02041x" stoichiometry="2" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02040x" stoichiometry="2" constant="true"/>
-          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Cat"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR20069" sboTerm="SBO:0000176" id="MAR20069" name="MAR20069" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -501452,7 +497767,7 @@
           <speciesReference species="MAM01288n" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CG33054"/>
+          <fbc:geneProductRef fbc:geneProduct="Targ1"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR20100" sboTerm="SBO:0000176" id="MAR20100" name="MAR20100" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -501482,7 +497797,7 @@
           <speciesReference species="MAM02583n" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CG33054"/>
+          <fbc:geneProductRef fbc:geneProduct="Targ1"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR20102" sboTerm="SBO:0000176" id="MAR20102" name="MAR20102" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -501769,6 +498084,96 @@
           <fbc:geneProductRef fbc:geneProduct="CG5793"/>
         </fbc:geneProductAssociation>
       </reaction>
+      <reaction metaid="MAR20112" sboTerm="SBO:0000176" id="MAR20112" name="MAR20112" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:10677481;PMID:16721829;PMID:17126822;PMID:235695;PMID:24055;PMID:6116153;PMID:6116159;PMID:6116163;PMID:6138355;PMID:7732023;PMID:9099716</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20112">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/6.4.1.2"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R04385"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96330"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13501"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM01371m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02046m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01357m" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01285m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02751m" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="ACC"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="MAR20113" sboTerm="SBO:0000185" id="MAR20113" name="MAR20113" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_MAR20113">
+              <bqbiol:is>
+                <rdf:Bag/>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM00185c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00185m" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction metaid="MAR20114" sboTerm="SBO:0000176" id="MAR20114" name="MAR20014" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:30378035</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#meta_MAR20114">
+              <bqbiol:is>
+                <rdf:Bag/>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM01803x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02630x" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01802x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02041x" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="CG8032"/>
+            <fbc:geneProductRef fbc:geneProduct="Daao1"/>
+            <fbc:geneProductRef fbc:geneProduct="Nos"/>
+            <fbc:geneProductRef fbc:geneProduct="ry"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
       <reaction metaid="MAR15001" sboTerm="SBO:0000176" id="MAR15001" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -502748,96 +499153,107 @@
           <fbc:geneProductRef fbc:geneProduct="se"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00113" sboTerm="SBO:0000176" id="MAR00113" name="C-3 Sterol Dehydrogenase (4-Methylzymosterol)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03931" sboTerm="SBO:0000176" id="MAR03931" name="NADPH:oxidized-thioredoxin oxidoreductase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10710235;PMID:14506130</p>
+            <p>AUTHORS: PMID:10462449;PMID:11060283;PMID:15110392</p>
             <p>NOTES: reaction added by gap filling</p>
           </body>
         </notes>
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00113">
+            <rdf:Description rdf:about="#MAR03931">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/C3STDH1Pr"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95038"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/C3STDH1Pr"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.8.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TRDR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02016"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104766"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/TRDR"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/20345"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02554r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM00953r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02555c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02666c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM01596r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02555r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM00809r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02554c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02990c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR00222" sboTerm="SBO:0000176" id="MAR00222" name="24-Dehydrocholesterol Reductase [Precursor]" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01557" sboTerm="SBO:0000176" id="MAR01557" name="lathosterol,ferrocytochrome b5:oxygen oxidoreductase 5,6-dehydrogenating" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:17984220;PMID:19520779;PMID:19520780</p>
+            <p>AUTHORS: PMID:11731337;PMID:7946524</p>
             <p>NOTES: reaction added by gap filling</p>
           </body>
         </notes>
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00222">
+            <rdf:Description rdf:about="#MAR01557">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.42"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DHCR243r"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97382"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/DHCR243r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.14.21.6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/LSTO2r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R07215"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101245"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR110903"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_1557"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/46556"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01803r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01675r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02343c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02553c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02630c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM01450r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01802r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02040c" stoichiometry="2" constant="true"/>
+          <speciesReference species="MAM02552c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02805c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR00443" sboTerm="SBO:0000176" id="MAR00443" name="3-Beta-Hydroxysteroid-Delta (8), Delta (7)-Isomerase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00114" sboTerm="SBO:0000176" id="MAR00114" name="C-3 Sterol Dehydrogenase (4-Methylzymosterol)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10391219</p>
+            <p>AUTHORS: PMID:12829805</p>
             <p>NOTES: reaction added by gap filling</p>
           </body>
         </notes>
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00443">
+            <rdf:Description rdf:about="#MAR00114">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.3.3.5"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EBP1r"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96689"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/EBP1r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/C3STDH1r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96410"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/C3STDH1r"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM03158r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02552r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00953r" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM01066r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01596r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02039r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02553r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00809r" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction metaid="MAR01498" sboTerm="SBO:0000176" id="MAR01498" name="Lanosterol Synthase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -502869,40 +499285,6 @@
           <speciesReference species="MAM02336r" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR01508" sboTerm="SBO:0000176" id="MAR01508" name="Lathosterol Oxidase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10344195</p>
-            <p>NOTES: reaction added by gap filling</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR01508">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.2"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/LSTO1r"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101244"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/LSTO1r"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02039r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02555r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01066r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02040r" stoichiometry="2" constant="true"/>
-          <speciesReference species="MAM02554r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01189r" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR01714" sboTerm="SBO:0000176" id="MAR01714" name="Squalene Epoxidase, Endoplasmic Reticular (NADP)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -503036,6 +499418,68 @@
           <speciesReference species="MAM00968r" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
+      <reaction metaid="MAR02337" sboTerm="SBO:0000176" id="MAR02337" name="Delta24-Sterol Reductase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:12162789;PMID:9291139;PMID:9638657</p>
+            <p>NOTES: reaction added by gap filling</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR02337">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.1.72"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1380"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105284"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1380"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM02039r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02555r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM03158r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02554r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01449r" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction metaid="MAR02339" sboTerm="SBO:0000176" id="MAR02339" name="5Alpha-Cholest-7-En-3Beta-Ol Delta7-Delta8-Isomerase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:10391219;PMID:12133002;PMID:4475632;PMID:5810070</p>
+            <p>NOTES: reaction added by gap filling</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR02339">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.3.3.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EBP2r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96687"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/EBP2r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1381"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM02343r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01449r" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
       <reaction metaid="MAR05151" sboTerm="SBO:0000176" id="MAR05151" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -503106,37 +499550,38 @@
           <speciesReference species="MAM03082c" stoichiometry="43" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR04497" sboTerm="SBO:0000176" id="MAR04497" name="3-hydroxypropanoate:NAD+ oxidoreductase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR04106" sboTerm="SBO:0000176" id="MAR04106" name="malonyl-CoA carboxy-lyase (acetyl-CoA-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:13672942</p>
+            <p>AUTHORS: PMID:101148;PMID:10455107;PMID:15003260;PMID:4180063;PMID:4731972;PMID:5578610;PMID:9869665</p>
             <p>NOTES: reaction added by gap filling</p>
           </body>
         </notes>
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR04497">
+            <rdf:Description rdf:about="#MAR04106">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.59"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01608"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR94902"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0365"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/13357"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.9"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MCDm"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00233"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101412"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/MCDm"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18782"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18781"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02142m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02552m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02444m" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM00900m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02553m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01261m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01596m" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction metaid="MAR04861" sboTerm="SBO:0000185" id="MAR04861" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
@@ -503168,6 +499613,41 @@
           <speciesReference species="MAM02171e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
+      <reaction metaid="MAR04485" sboTerm="SBO:0000176" id="MAR04485" name="thymidine:phosphate deoxy-alpha-D-ribosyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:15262124;PMID:15990964</p>
+            <p>NOTES: reaction added by gap filling</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR04485">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.4"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TMDPP"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01570"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104887"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/TMDPP"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16040"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16037"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM00639c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02997c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02751c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02996c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
       <reaction metaid="MAR06981" sboTerm="SBO:0000176" id="MAR06981" name="4-Trimethylammoniobutanal:NAD+ 1-oxidoreductase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -503235,6 +499715,38 @@
           <speciesReference species="MAM02554c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
+      <reaction metaid="MAR02472" sboTerm="SBO:0000176" id="MAR02472" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+            <p>NOTES: reaction added by gap filling</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR02472">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.14.19.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HMR_2472"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_2472"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02390c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02555c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02630c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00108c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02040c" stoichiometry="2" constant="true"/>
+          <speciesReference species="MAM02554c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
       <reaction metaid="MAR02505" sboTerm="SBO:0000176" id="MAR02505" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -504070,40 +500582,7 @@
           <speciesReference species="MAM01599m" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR00145" sboTerm="SBO:0000176" id="MAR00145" name="Fatty Acyl Coenzyme A Desaturase (N-C18:2CoA -&gt; N-C18:3CoA)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>NOTES: reaction added by gap filling</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00145">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.14.19.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DESAT18_10"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97241"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/DESAT18_10"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02390c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02553c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00108c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02040c" stoichiometry="2" constant="true"/>
-          <speciesReference species="MAM02552c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR00151" sboTerm="SBO:0000176" id="MAR00151" name="Fatty Acyl Coenzyme A Desaturase (N-C18:1CoA -&gt; N-C18:2CoA)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00149" sboTerm="SBO:0000176" id="MAR00149" name="Fatty Acyl Coenzyme A Desaturase (N-C18:1CoA -&gt; N-C18:2CoA)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -504112,23 +500591,23 @@
         </notes>
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00151">
+            <rdf:Description rdf:about="#MAR00149">
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.14.99.25"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DESAT18_8"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97248"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/DESAT18_8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DESAT18_6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97246"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/DESAT18_6"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00057c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02630c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02647c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00106c" stoichiometry="1" constant="true"/>
@@ -504140,7 +500619,7 @@
     <fbc:listOfObjectives fbc:activeObjective="obj">
       <fbc:objective fbc:id="obj" fbc:type="maximize">
         <fbc:listOfFluxObjectives>
-          <fbc:fluxObjective fbc:reaction="MAR13082" fbc:coefficient="1"/>
+          <fbc:fluxObjective fbc:reaction="MAR00021" fbc:coefficient="1"/>
         </fbc:listOfFluxObjectives>
       </fbc:objective>
     </fbc:listOfObjectives>
@@ -504189,13 +500668,13 @@
       <fbc:geneProduct metaid="G_Acsf2" sboTerm="SBO:0000243" fbc:id="G_Acsf2" fbc:label="Acsf2"/>
       <fbc:geneProduct metaid="G_Acsf3" sboTerm="SBO:0000243" fbc:id="G_Acsf3" fbc:label="Acsf3"/>
       <fbc:geneProduct metaid="G_Acsl" sboTerm="SBO:0000243" fbc:id="G_Acsl" fbc:label="Acsl"/>
-      <fbc:geneProduct metaid="G_AdSL" sboTerm="SBO:0000243" fbc:id="G_AdSL" fbc:label="AdSL"/>
-      <fbc:geneProduct metaid="G_AdSS" sboTerm="SBO:0000243" fbc:id="G_AdSS" fbc:label="AdSS"/>
       <fbc:geneProduct metaid="G_Adgf__45__A" sboTerm="SBO:0000243" fbc:id="G_Adgf__45__A" fbc:label="Adgf-A"/>
       <fbc:geneProduct metaid="G_Adgf__45__B" sboTerm="SBO:0000243" fbc:id="G_Adgf__45__B" fbc:label="Adgf-B"/>
       <fbc:geneProduct metaid="G_Adgf__45__E" sboTerm="SBO:0000243" fbc:id="G_Adgf__45__E" fbc:label="Adgf-E"/>
       <fbc:geneProduct metaid="G_Adi1" sboTerm="SBO:0000243" fbc:id="G_Adi1" fbc:label="Adi1"/>
       <fbc:geneProduct metaid="G_Adk2" sboTerm="SBO:0000243" fbc:id="G_Adk2" fbc:label="Adk2"/>
+      <fbc:geneProduct metaid="G_Adsl" sboTerm="SBO:0000243" fbc:id="G_Adsl" fbc:label="Adsl"/>
+      <fbc:geneProduct metaid="G_Adss" sboTerm="SBO:0000243" fbc:id="G_Adss" fbc:label="Adss"/>
       <fbc:geneProduct metaid="G_Ae2" sboTerm="SBO:0000243" fbc:id="G_Ae2" fbc:label="Ae2"/>
       <fbc:geneProduct metaid="G_Agpat1" sboTerm="SBO:0000243" fbc:id="G_Agpat1" fbc:label="Agpat1"/>
       <fbc:geneProduct metaid="G_Agpat3" sboTerm="SBO:0000243" fbc:id="G_Agpat3" fbc:label="Agpat3"/>
@@ -504244,7 +500723,6 @@
       <fbc:geneProduct metaid="G_Argk1" sboTerm="SBO:0000243" fbc:id="G_Argk1" fbc:label="Argk1"/>
       <fbc:geneProduct metaid="G_Argk2" sboTerm="SBO:0000243" fbc:id="G_Argk2" fbc:label="Argk2"/>
       <fbc:geneProduct metaid="G_Argl" sboTerm="SBO:0000243" fbc:id="G_Argl" fbc:label="Argl"/>
-      <fbc:geneProduct metaid="G_Art4" sboTerm="SBO:0000243" fbc:id="G_Art4" fbc:label="Art4"/>
       <fbc:geneProduct metaid="G_AsnRS" sboTerm="SBO:0000243" fbc:id="G_AsnRS" fbc:label="AsnRS"/>
       <fbc:geneProduct metaid="G_AsnS" sboTerm="SBO:0000243" fbc:id="G_AsnS" fbc:label="AsnS"/>
       <fbc:geneProduct metaid="G_AspRS" sboTerm="SBO:0000243" fbc:id="G_AspRS" fbc:label="AspRS"/>
@@ -504258,6 +500736,8 @@
       <fbc:geneProduct metaid="G_Balat" sboTerm="SBO:0000243" fbc:id="G_Balat" fbc:label="Balat"/>
       <fbc:geneProduct metaid="G_Baldspot" sboTerm="SBO:0000243" fbc:id="G_Baldspot" fbc:label="Baldspot"/>
       <fbc:geneProduct metaid="G_Bcat" sboTerm="SBO:0000243" fbc:id="G_Bcat" fbc:label="Bcat"/>
+      <fbc:geneProduct metaid="G_BckdhA" sboTerm="SBO:0000243" fbc:id="G_BckdhA" fbc:label="BckdhA"/>
+      <fbc:geneProduct metaid="G_BckdhB" sboTerm="SBO:0000243" fbc:id="G_BckdhB" fbc:label="BckdhB"/>
       <fbc:geneProduct metaid="G_Bmcp" sboTerm="SBO:0000243" fbc:id="G_Bmcp" fbc:label="Bmcp"/>
       <fbc:geneProduct metaid="G_Br140" sboTerm="SBO:0000243" fbc:id="G_Br140" fbc:label="Br140"/>
       <fbc:geneProduct metaid="G_Bre1" sboTerm="SBO:0000243" fbc:id="G_Bre1" fbc:label="Bre1"/>
@@ -504285,11 +500765,9 @@
       <fbc:geneProduct metaid="G_CG10357" sboTerm="SBO:0000243" fbc:id="G_CG10357" fbc:label="CG10357"/>
       <fbc:geneProduct metaid="G_CG10444" sboTerm="SBO:0000243" fbc:id="G_CG10444" fbc:label="CG10444"/>
       <fbc:geneProduct metaid="G_CG10467" sboTerm="SBO:0000243" fbc:id="G_CG10467" fbc:label="CG10467"/>
-      <fbc:geneProduct metaid="G_CG10483" sboTerm="SBO:0000243" fbc:id="G_CG10483" fbc:label="CG10483"/>
       <fbc:geneProduct metaid="G_CG10486" sboTerm="SBO:0000243" fbc:id="G_CG10486" fbc:label="CG10486"/>
       <fbc:geneProduct metaid="G_CG10581" sboTerm="SBO:0000243" fbc:id="G_CG10581" fbc:label="CG10581"/>
       <fbc:geneProduct metaid="G_CG10602" sboTerm="SBO:0000243" fbc:id="G_CG10602" fbc:label="CG10602"/>
-      <fbc:geneProduct metaid="G_CG10651" sboTerm="SBO:0000243" fbc:id="G_CG10651" fbc:label="CG10651"/>
       <fbc:geneProduct metaid="G_CG10657" sboTerm="SBO:0000243" fbc:id="G_CG10657" fbc:label="CG10657"/>
       <fbc:geneProduct metaid="G_CG1074" sboTerm="SBO:0000243" fbc:id="G_CG1074" fbc:label="CG1074"/>
       <fbc:geneProduct metaid="G_CG10747" sboTerm="SBO:0000243" fbc:id="G_CG10747" fbc:label="CG10747"/>
@@ -504395,7 +500873,6 @@
       <fbc:geneProduct metaid="G_CG17633" sboTerm="SBO:0000243" fbc:id="G_CG17633" fbc:label="CG17633"/>
       <fbc:geneProduct metaid="G_CG17636" sboTerm="SBO:0000243" fbc:id="G_CG17636" fbc:label="CG17636"/>
       <fbc:geneProduct metaid="G_CG1764" sboTerm="SBO:0000243" fbc:id="G_CG1764" fbc:label="CG1764"/>
-      <fbc:geneProduct metaid="G_CG17691" sboTerm="SBO:0000243" fbc:id="G_CG17691" fbc:label="CG17691"/>
       <fbc:geneProduct metaid="G_CG17717" sboTerm="SBO:0000243" fbc:id="G_CG17717" fbc:label="CG17717"/>
       <fbc:geneProduct metaid="G_CG1774" sboTerm="SBO:0000243" fbc:id="G_CG1774" fbc:label="CG1774"/>
       <fbc:geneProduct metaid="G_CG17751" sboTerm="SBO:0000243" fbc:id="G_CG17751" fbc:label="CG17751"/>
@@ -504420,6 +500897,7 @@
       <fbc:geneProduct metaid="G_CG2201" sboTerm="SBO:0000243" fbc:id="G_CG2201" fbc:label="CG2201"/>
       <fbc:geneProduct metaid="G_CG2224" sboTerm="SBO:0000243" fbc:id="G_CG2224" fbc:label="CG2224"/>
       <fbc:geneProduct metaid="G_CG2528" sboTerm="SBO:0000243" fbc:id="G_CG2528" fbc:label="CG2528"/>
+      <fbc:geneProduct metaid="G_CG2604" sboTerm="SBO:0000243" fbc:id="G_CG2604" fbc:label="CG2604"/>
       <fbc:geneProduct metaid="G_CG2680" sboTerm="SBO:0000243" fbc:id="G_CG2680" fbc:label="CG2680"/>
       <fbc:geneProduct metaid="G_CG2794" sboTerm="SBO:0000243" fbc:id="G_CG2794" fbc:label="CG2794"/>
       <fbc:geneProduct metaid="G_CG2818" sboTerm="SBO:0000243" fbc:id="G_CG2818" fbc:label="CG2818"/>
@@ -504434,7 +500912,6 @@
       <fbc:geneProduct metaid="G_CG30338" sboTerm="SBO:0000243" fbc:id="G_CG30338" fbc:label="CG30338"/>
       <fbc:geneProduct metaid="G_CG30344" sboTerm="SBO:0000243" fbc:id="G_CG30344" fbc:label="CG30344"/>
       <fbc:geneProduct metaid="G_CG30345" sboTerm="SBO:0000243" fbc:id="G_CG30345" fbc:label="CG30345"/>
-      <fbc:geneProduct metaid="G_CG30486" sboTerm="SBO:0000243" fbc:id="G_CG30486" fbc:label="CG30486"/>
       <fbc:geneProduct metaid="G_CG30491" sboTerm="SBO:0000243" fbc:id="G_CG30491" fbc:label="CG30491"/>
       <fbc:geneProduct metaid="G_CG31075" sboTerm="SBO:0000243" fbc:id="G_CG31075" fbc:label="CG31075"/>
       <fbc:geneProduct metaid="G_CG31121" sboTerm="SBO:0000243" fbc:id="G_CG31121" fbc:label="CG31121"/>
@@ -504469,7 +500946,6 @@
       <fbc:geneProduct metaid="G_CG32751" sboTerm="SBO:0000243" fbc:id="G_CG32751" fbc:label="CG32751"/>
       <fbc:geneProduct metaid="G_CG32808" sboTerm="SBO:0000243" fbc:id="G_CG32808" fbc:label="CG32808"/>
       <fbc:geneProduct metaid="G_CG32847" sboTerm="SBO:0000243" fbc:id="G_CG32847" fbc:label="CG32847"/>
-      <fbc:geneProduct metaid="G_CG33054" sboTerm="SBO:0000243" fbc:id="G_CG33054" fbc:label="CG33054"/>
       <fbc:geneProduct metaid="G_CG33090" sboTerm="SBO:0000243" fbc:id="G_CG33090" fbc:label="CG33090"/>
       <fbc:geneProduct metaid="G_CG33116" sboTerm="SBO:0000243" fbc:id="G_CG33116" fbc:label="CG33116"/>
       <fbc:geneProduct metaid="G_CG33144" sboTerm="SBO:0000243" fbc:id="G_CG33144" fbc:label="CG33144"/>
@@ -504483,7 +500959,6 @@
       <fbc:geneProduct metaid="G_CG3356" sboTerm="SBO:0000243" fbc:id="G_CG3356" fbc:label="CG3356"/>
       <fbc:geneProduct metaid="G_CG3376" sboTerm="SBO:0000243" fbc:id="G_CG3376" fbc:label="CG3376"/>
       <fbc:geneProduct metaid="G_CG33934" sboTerm="SBO:0000243" fbc:id="G_CG33934" fbc:label="CG33934"/>
-      <fbc:geneProduct metaid="G_CG34002" sboTerm="SBO:0000243" fbc:id="G_CG34002" fbc:label="CG34002"/>
       <fbc:geneProduct metaid="G_CG34057" sboTerm="SBO:0000243" fbc:id="G_CG34057" fbc:label="CG34057"/>
       <fbc:geneProduct metaid="G_CG34161" sboTerm="SBO:0000243" fbc:id="G_CG34161" fbc:label="CG34161"/>
       <fbc:geneProduct metaid="G_CG34174" sboTerm="SBO:0000243" fbc:id="G_CG34174" fbc:label="CG34174"/>
@@ -504547,6 +501022,7 @@
       <fbc:geneProduct metaid="G_CG5103" sboTerm="SBO:0000243" fbc:id="G_CG5103" fbc:label="CG5103"/>
       <fbc:geneProduct metaid="G_CG5144" sboTerm="SBO:0000243" fbc:id="G_CG5144" fbc:label="CG5144"/>
       <fbc:geneProduct metaid="G_CG5162" sboTerm="SBO:0000243" fbc:id="G_CG5162" fbc:label="CG5162"/>
+      <fbc:geneProduct metaid="G_CG5167" sboTerm="SBO:0000243" fbc:id="G_CG5167" fbc:label="CG5167"/>
       <fbc:geneProduct metaid="G_CG5196" sboTerm="SBO:0000243" fbc:id="G_CG5196" fbc:label="CG5196"/>
       <fbc:geneProduct metaid="G_CG5214" sboTerm="SBO:0000243" fbc:id="G_CG5214" fbc:label="CG5214"/>
       <fbc:geneProduct metaid="G_CG5254" sboTerm="SBO:0000243" fbc:id="G_CG5254" fbc:label="CG5254"/>
@@ -504606,8 +501082,6 @@
       <fbc:geneProduct metaid="G_CG6805" sboTerm="SBO:0000243" fbc:id="G_CG6805" fbc:label="CG6805"/>
       <fbc:geneProduct metaid="G_CG6836" sboTerm="SBO:0000243" fbc:id="G_CG6836" fbc:label="CG6836"/>
       <fbc:geneProduct metaid="G_CG6847" sboTerm="SBO:0000243" fbc:id="G_CG6847" fbc:label="CG6847"/>
-      <fbc:geneProduct metaid="G_CG6903" sboTerm="SBO:0000243" fbc:id="G_CG6903" fbc:label="CG6903"/>
-      <fbc:geneProduct metaid="G_CG6910" sboTerm="SBO:0000243" fbc:id="G_CG6910" fbc:label="CG6910"/>
       <fbc:geneProduct metaid="G_CG6951" sboTerm="SBO:0000243" fbc:id="G_CG6951" fbc:label="CG6951"/>
       <fbc:geneProduct metaid="G_CG6962" sboTerm="SBO:0000243" fbc:id="G_CG6962" fbc:label="CG6962"/>
       <fbc:geneProduct metaid="G_CG7025" sboTerm="SBO:0000243" fbc:id="G_CG7025" fbc:label="CG7025"/>
@@ -504650,11 +501124,9 @@
       <fbc:geneProduct metaid="G_CG8032" sboTerm="SBO:0000243" fbc:id="G_CG8032" fbc:label="CG8032"/>
       <fbc:geneProduct metaid="G_CG8036" sboTerm="SBO:0000243" fbc:id="G_CG8036" fbc:label="CG8036"/>
       <fbc:geneProduct metaid="G_CG8046" sboTerm="SBO:0000243" fbc:id="G_CG8046" fbc:label="CG8046"/>
-      <fbc:geneProduct metaid="G_CG8072" sboTerm="SBO:0000243" fbc:id="G_CG8072" fbc:label="CG8072"/>
       <fbc:geneProduct metaid="G_CG8112" sboTerm="SBO:0000243" fbc:id="G_CG8112" fbc:label="CG8112"/>
       <fbc:geneProduct metaid="G_CG8132" sboTerm="SBO:0000243" fbc:id="G_CG8132" fbc:label="CG8132"/>
       <fbc:geneProduct metaid="G_CG8188" sboTerm="SBO:0000243" fbc:id="G_CG8188" fbc:label="CG8188"/>
-      <fbc:geneProduct metaid="G_CG8199" sboTerm="SBO:0000243" fbc:id="G_CG8199" fbc:label="CG8199"/>
       <fbc:geneProduct metaid="G_CG8314" sboTerm="SBO:0000243" fbc:id="G_CG8314" fbc:label="CG8314"/>
       <fbc:geneProduct metaid="G_CG8353" sboTerm="SBO:0000243" fbc:id="G_CG8353" fbc:label="CG8353"/>
       <fbc:geneProduct metaid="G_CG8360" sboTerm="SBO:0000243" fbc:id="G_CG8360" fbc:label="CG8360"/>
@@ -504688,7 +501160,7 @@
       <fbc:geneProduct metaid="G_CG9541" sboTerm="SBO:0000243" fbc:id="G_CG9541" fbc:label="CG9541"/>
       <fbc:geneProduct metaid="G_CG9547" sboTerm="SBO:0000243" fbc:id="G_CG9547" fbc:label="CG9547"/>
       <fbc:geneProduct metaid="G_CG9550" sboTerm="SBO:0000243" fbc:id="G_CG9550" fbc:label="CG9550"/>
-      <fbc:geneProduct metaid="G_CG9593" sboTerm="SBO:0000243" fbc:id="G_CG9593" fbc:label="CG9593"/>
+      <fbc:geneProduct metaid="G_CG9577" sboTerm="SBO:0000243" fbc:id="G_CG9577" fbc:label="CG9577"/>
       <fbc:geneProduct metaid="G_CG9701" sboTerm="SBO:0000243" fbc:id="G_CG9701" fbc:label="CG9701"/>
       <fbc:geneProduct metaid="G_CG9706" sboTerm="SBO:0000243" fbc:id="G_CG9706" fbc:label="CG9706"/>
       <fbc:geneProduct metaid="G_CG9784" sboTerm="SBO:0000243" fbc:id="G_CG9784" fbc:label="CG9784"/>
@@ -504820,7 +501292,6 @@
       <fbc:geneProduct metaid="G_ERp60" sboTerm="SBO:0000243" fbc:id="G_ERp60" fbc:label="ERp60"/>
       <fbc:geneProduct metaid="G_Eaat1" sboTerm="SBO:0000243" fbc:id="G_Eaat1" fbc:label="Eaat1"/>
       <fbc:geneProduct metaid="G_Eaat2" sboTerm="SBO:0000243" fbc:id="G_Eaat2" fbc:label="Eaat2"/>
-      <fbc:geneProduct metaid="G_Ech1" sboTerm="SBO:0000243" fbc:id="G_Ech1" fbc:label="Ech1"/>
       <fbc:geneProduct metaid="G_Echs1" sboTerm="SBO:0000243" fbc:id="G_Echs1" fbc:label="Echs1"/>
       <fbc:geneProduct metaid="G_Ect3" sboTerm="SBO:0000243" fbc:id="G_Ect3" fbc:label="Ect3"/>
       <fbc:geneProduct metaid="G_Efr" sboTerm="SBO:0000243" fbc:id="G_Efr" fbc:label="Efr"/>
@@ -504829,7 +501300,6 @@
       <fbc:geneProduct metaid="G_Eglp3" sboTerm="SBO:0000243" fbc:id="G_Eglp3" fbc:label="Eglp3"/>
       <fbc:geneProduct metaid="G_Eglp4" sboTerm="SBO:0000243" fbc:id="G_Eglp4" fbc:label="Eglp4"/>
       <fbc:geneProduct metaid="G_Egm" sboTerm="SBO:0000243" fbc:id="G_Egm" fbc:label="Egm"/>
-      <fbc:geneProduct metaid="G_Eip75B" sboTerm="SBO:0000243" fbc:id="G_Eip75B" fbc:label="Eip75B"/>
       <fbc:geneProduct metaid="G_Elo68__945__" sboTerm="SBO:0000243" fbc:id="G_Elo68__945__" fbc:label="Elo68α"/>
       <fbc:geneProduct metaid="G_Elo68__946__" sboTerm="SBO:0000243" fbc:id="G_Elo68__946__" fbc:label="Elo68β"/>
       <fbc:geneProduct metaid="G_Elovl7" sboTerm="SBO:0000243" fbc:id="G_Elovl7" fbc:label="Elovl7"/>
@@ -504911,11 +501381,11 @@
       <fbc:geneProduct metaid="G_Glo1" sboTerm="SBO:0000243" fbc:id="G_Glo1" fbc:label="Glo1"/>
       <fbc:geneProduct metaid="G_GluProRS" sboTerm="SBO:0000243" fbc:id="G_GluProRS" fbc:label="GluProRS"/>
       <fbc:geneProduct metaid="G_Glut1" sboTerm="SBO:0000243" fbc:id="G_Glut1" fbc:label="Glut1"/>
-      <fbc:geneProduct metaid="G_GlyP" sboTerm="SBO:0000243" fbc:id="G_GlyP" fbc:label="GlyP"/>
       <fbc:geneProduct metaid="G_GlyRS" sboTerm="SBO:0000243" fbc:id="G_GlyRS" fbc:label="GlyRS"/>
-      <fbc:geneProduct metaid="G_GlyS" sboTerm="SBO:0000243" fbc:id="G_GlyS" fbc:label="GlyS"/>
       <fbc:geneProduct metaid="G_GlyT" sboTerm="SBO:0000243" fbc:id="G_GlyT" fbc:label="GlyT"/>
       <fbc:geneProduct metaid="G_Glyat" sboTerm="SBO:0000243" fbc:id="G_Glyat" fbc:label="Glyat"/>
+      <fbc:geneProduct metaid="G_Glyp" sboTerm="SBO:0000243" fbc:id="G_Glyp" fbc:label="Glyp"/>
+      <fbc:geneProduct metaid="G_Glys" sboTerm="SBO:0000243" fbc:id="G_Glys" fbc:label="Glys"/>
       <fbc:geneProduct metaid="G_Gmd" sboTerm="SBO:0000243" fbc:id="G_Gmd" fbc:label="Gmd"/>
       <fbc:geneProduct metaid="G_Gmer" sboTerm="SBO:0000243" fbc:id="G_Gmer" fbc:label="Gmer"/>
       <fbc:geneProduct metaid="G_Gmppb" sboTerm="SBO:0000243" fbc:id="G_Gmppb" fbc:label="Gmppb"/>
@@ -504945,7 +501415,6 @@
       <fbc:geneProduct metaid="G_Gyc__945__99B" sboTerm="SBO:0000243" fbc:id="G_Gyc__945__99B" fbc:label="Gycα99B"/>
       <fbc:geneProduct metaid="G_Gyc__946__100B" sboTerm="SBO:0000243" fbc:id="G_Gyc__946__100B" fbc:label="Gycβ100B"/>
       <fbc:geneProduct metaid="G_Gyg" sboTerm="SBO:0000243" fbc:id="G_Gyg" fbc:label="Gyg"/>
-      <fbc:geneProduct metaid="G_HDAC3" sboTerm="SBO:0000243" fbc:id="G_HDAC3" fbc:label="HDAC3"/>
       <fbc:geneProduct metaid="G_HERC2" sboTerm="SBO:0000243" fbc:id="G_HERC2" fbc:label="HERC2"/>
       <fbc:geneProduct metaid="G_HUWE1" sboTerm="SBO:0000243" fbc:id="G_HUWE1" fbc:label="HUWE1"/>
       <fbc:geneProduct metaid="G_Hacd1" sboTerm="SBO:0000243" fbc:id="G_Hacd1" fbc:label="Hacd1"/>
@@ -504963,6 +501432,7 @@
       <fbc:geneProduct metaid="G_Hex__45__A" sboTerm="SBO:0000243" fbc:id="G_Hex__45__A" fbc:label="Hex-A"/>
       <fbc:geneProduct metaid="G_Hex__45__C" sboTerm="SBO:0000243" fbc:id="G_Hex__45__C" fbc:label="Hex-C"/>
       <fbc:geneProduct metaid="G_Hex__45__t2" sboTerm="SBO:0000243" fbc:id="G_Hex__45__t2" fbc:label="Hex-t2"/>
+      <fbc:geneProduct metaid="G_Hgsnat" sboTerm="SBO:0000243" fbc:id="G_Hgsnat" fbc:label="Hgsnat"/>
       <fbc:geneProduct metaid="G_Hibch" sboTerm="SBO:0000243" fbc:id="G_Hibch" fbc:label="Hibch"/>
       <fbc:geneProduct metaid="G_Hip14" sboTerm="SBO:0000243" fbc:id="G_Hip14" fbc:label="Hip14"/>
       <fbc:geneProduct metaid="G_HisRS" sboTerm="SBO:0000243" fbc:id="G_HisRS" fbc:label="HisRS"/>
@@ -504975,7 +501445,6 @@
       <fbc:geneProduct metaid="G_Hn" sboTerm="SBO:0000243" fbc:id="G_Hn" fbc:label="Hn"/>
       <fbc:geneProduct metaid="G_Ho" sboTerm="SBO:0000243" fbc:id="G_Ho" fbc:label="Ho"/>
       <fbc:geneProduct metaid="G_Hpd" sboTerm="SBO:0000243" fbc:id="G_Hpd" fbc:label="Hpd"/>
-      <fbc:geneProduct metaid="G_Hr3" sboTerm="SBO:0000243" fbc:id="G_Hr3" fbc:label="Hr3"/>
       <fbc:geneProduct metaid="G_Hs2st" sboTerm="SBO:0000243" fbc:id="G_Hs2st" fbc:label="Hs2st"/>
       <fbc:geneProduct metaid="G_Hs3st__45__A" sboTerm="SBO:0000243" fbc:id="G_Hs3st__45__A" fbc:label="Hs3st-A"/>
       <fbc:geneProduct metaid="G_Hs3st__45__B" sboTerm="SBO:0000243" fbc:id="G_Hs3st__45__B" fbc:label="Hs3st-B"/>
@@ -504992,6 +501461,7 @@
       <fbc:geneProduct metaid="G_Idi" sboTerm="SBO:0000243" fbc:id="G_Idi" fbc:label="Idi"/>
       <fbc:geneProduct metaid="G_Ids" sboTerm="SBO:0000243" fbc:id="G_Ids" fbc:label="Ids"/>
       <fbc:geneProduct metaid="G_Idua" sboTerm="SBO:0000243" fbc:id="G_Idua" fbc:label="Idua"/>
+      <fbc:geneProduct metaid="G_Ih" sboTerm="SBO:0000243" fbc:id="G_Ih" fbc:label="Ih"/>
       <fbc:geneProduct metaid="G_IleRS" sboTerm="SBO:0000243" fbc:id="G_IleRS" fbc:label="IleRS"/>
       <fbc:geneProduct metaid="G_Indy" sboTerm="SBO:0000243" fbc:id="G_Indy" fbc:label="Indy"/>
       <fbc:geneProduct metaid="G_Indy__45__2" sboTerm="SBO:0000243" fbc:id="G_Indy__45__2" fbc:label="Indy-2"/>
@@ -505067,6 +501537,7 @@
       <fbc:geneProduct metaid="G_Mgat4b" sboTerm="SBO:0000243" fbc:id="G_Mgat4b" fbc:label="Mgat4b"/>
       <fbc:geneProduct metaid="G_Mgstl" sboTerm="SBO:0000243" fbc:id="G_Mgstl" fbc:label="Mgstl"/>
       <fbc:geneProduct metaid="G_Mgtor" sboTerm="SBO:0000243" fbc:id="G_Mgtor" fbc:label="Mgtor"/>
+      <fbc:geneProduct metaid="G_Miox" sboTerm="SBO:0000243" fbc:id="G_Miox" fbc:label="Miox"/>
       <fbc:geneProduct metaid="G_Mipp2" sboTerm="SBO:0000243" fbc:id="G_Mipp2" fbc:label="Mipp2"/>
       <fbc:geneProduct metaid="G_Mkrn1" sboTerm="SBO:0000243" fbc:id="G_Mkrn1" fbc:label="Mkrn1"/>
       <fbc:geneProduct metaid="G_Mnat9" sboTerm="SBO:0000243" fbc:id="G_Mnat9" fbc:label="Mnat9"/>
@@ -505085,7 +501556,6 @@
       <fbc:geneProduct metaid="G_Mtap" sboTerm="SBO:0000243" fbc:id="G_Mtap" fbc:label="Mtap"/>
       <fbc:geneProduct metaid="G_Mthfs" sboTerm="SBO:0000243" fbc:id="G_Mthfs" fbc:label="Mthfs"/>
       <fbc:geneProduct metaid="G_Mtmr6" sboTerm="SBO:0000243" fbc:id="G_Mtmr6" fbc:label="Mtmr6"/>
-      <fbc:geneProduct metaid="G_Mtp" sboTerm="SBO:0000243" fbc:id="G_Mtp" fbc:label="Mtp"/>
       <fbc:geneProduct metaid="G_Mtp__945__" sboTerm="SBO:0000243" fbc:id="G_Mtp__945__" fbc:label="Mtpα"/>
       <fbc:geneProduct metaid="G_Mtp__946__" sboTerm="SBO:0000243" fbc:id="G_Mtp__946__" fbc:label="Mtpβ"/>
       <fbc:geneProduct metaid="G_Mtr4" sboTerm="SBO:0000243" fbc:id="G_Mtr4" fbc:label="Mtr4"/>
@@ -505150,7 +501620,6 @@
       <fbc:geneProduct metaid="G_Naprt" sboTerm="SBO:0000243" fbc:id="G_Naprt" fbc:label="Naprt"/>
       <fbc:geneProduct metaid="G_Ncc69" sboTerm="SBO:0000243" fbc:id="G_Ncc69" fbc:label="Ncc69"/>
       <fbc:geneProduct metaid="G_Nckx30C" sboTerm="SBO:0000243" fbc:id="G_Nckx30C" fbc:label="Nckx30C"/>
-      <fbc:geneProduct metaid="G_Ncoa6" sboTerm="SBO:0000243" fbc:id="G_Ncoa6" fbc:label="Ncoa6"/>
       <fbc:geneProduct metaid="G_Ndae1" sboTerm="SBO:0000243" fbc:id="G_Ndae1" fbc:label="Ndae1"/>
       <fbc:geneProduct metaid="G_Ndc1" sboTerm="SBO:0000243" fbc:id="G_Ndc1" fbc:label="Ndc1"/>
       <fbc:geneProduct metaid="G_Neb__45__cGP" sboTerm="SBO:0000243" fbc:id="G_Neb__45__cGP" fbc:label="Neb-cGP"/>
@@ -505254,11 +501723,12 @@
       <fbc:geneProduct metaid="G_PNKP" sboTerm="SBO:0000243" fbc:id="G_PNKP" fbc:label="PNKP"/>
       <fbc:geneProduct metaid="G_POSH" sboTerm="SBO:0000243" fbc:id="G_POSH" fbc:label="POSH"/>
       <fbc:geneProduct metaid="G_PTPMT1" sboTerm="SBO:0000243" fbc:id="G_PTPMT1" fbc:label="PTPMT1"/>
+      <fbc:geneProduct metaid="G_PXo" sboTerm="SBO:0000243" fbc:id="G_PXo" fbc:label="PXo"/>
       <fbc:geneProduct metaid="G_Paf__45__AH__945__" sboTerm="SBO:0000243" fbc:id="G_Paf__45__AH__945__" fbc:label="Paf-AHα"/>
       <fbc:geneProduct metaid="G_Paics" sboTerm="SBO:0000243" fbc:id="G_Paics" fbc:label="Paics"/>
       <fbc:geneProduct metaid="G_Pal1" sboTerm="SBO:0000243" fbc:id="G_Pal1" fbc:label="Pal1"/>
       <fbc:geneProduct metaid="G_Papss" sboTerm="SBO:0000243" fbc:id="G_Papss" fbc:label="Papss"/>
-      <fbc:geneProduct metaid="G_Parp" sboTerm="SBO:0000243" fbc:id="G_Parp" fbc:label="Parp"/>
+      <fbc:geneProduct metaid="G_Parp1" sboTerm="SBO:0000243" fbc:id="G_Parp1" fbc:label="Parp1"/>
       <fbc:geneProduct metaid="G_Parp16" sboTerm="SBO:0000243" fbc:id="G_Parp16" fbc:label="Parp16"/>
       <fbc:geneProduct metaid="G_Pbgs" sboTerm="SBO:0000243" fbc:id="G_Pbgs" fbc:label="Pbgs"/>
       <fbc:geneProduct metaid="G_Pcd" sboTerm="SBO:0000243" fbc:id="G_Pcd" fbc:label="Pcd"/>
@@ -505281,7 +501751,6 @@
       <fbc:geneProduct metaid="G_Pect" sboTerm="SBO:0000243" fbc:id="G_Pect" fbc:label="Pect"/>
       <fbc:geneProduct metaid="G_Pepck1" sboTerm="SBO:0000243" fbc:id="G_Pepck1" fbc:label="Pepck1"/>
       <fbc:geneProduct metaid="G_Pepck2" sboTerm="SBO:0000243" fbc:id="G_Pepck2" fbc:label="Pepck2"/>
-      <fbc:geneProduct metaid="G_Pex11ab" sboTerm="SBO:0000243" fbc:id="G_Pex11ab" fbc:label="Pex11ab"/>
       <fbc:geneProduct metaid="G_Pfas" sboTerm="SBO:0000243" fbc:id="G_Pfas" fbc:label="Pfas"/>
       <fbc:geneProduct metaid="G_Pfk" sboTerm="SBO:0000243" fbc:id="G_Pfk" fbc:label="Pfk"/>
       <fbc:geneProduct metaid="G_Pfrx" sboTerm="SBO:0000243" fbc:id="G_Pfrx" fbc:label="Pfrx"/>
@@ -505310,7 +501779,6 @@
       <fbc:geneProduct metaid="G_Pi4KII__945__" sboTerm="SBO:0000243" fbc:id="G_Pi4KII__945__" fbc:label="Pi4KIIα"/>
       <fbc:geneProduct metaid="G_Pis" sboTerm="SBO:0000243" fbc:id="G_Pis" fbc:label="Pis"/>
       <fbc:geneProduct metaid="G_Pisd" sboTerm="SBO:0000243" fbc:id="G_Pisd" fbc:label="Pisd"/>
-      <fbc:geneProduct metaid="G_Pka__45__C1" sboTerm="SBO:0000243" fbc:id="G_Pka__45__C1" fbc:label="Pka-C1"/>
       <fbc:geneProduct metaid="G_Plc21C" sboTerm="SBO:0000243" fbc:id="G_Plc21C" fbc:label="Plc21C"/>
       <fbc:geneProduct metaid="G_Pld" sboTerm="SBO:0000243" fbc:id="G_Pld" fbc:label="Pld"/>
       <fbc:geneProduct metaid="G_Plod" sboTerm="SBO:0000243" fbc:id="G_Plod" fbc:label="Plod"/>
@@ -505358,7 +501826,6 @@
       <fbc:geneProduct metaid="G_Polr3H" sboTerm="SBO:0000243" fbc:id="G_Polr3H" fbc:label="Polr3H"/>
       <fbc:geneProduct metaid="G_Polr3K" sboTerm="SBO:0000243" fbc:id="G_Polr3K" fbc:label="Polr3K"/>
       <fbc:geneProduct metaid="G_PolrMT" sboTerm="SBO:0000243" fbc:id="G_PolrMT" fbc:label="PolrMT"/>
-      <fbc:geneProduct metaid="G_Pp1__45__87B" sboTerm="SBO:0000243" fbc:id="G_Pp1__45__87B" fbc:label="Pp1-87B"/>
       <fbc:geneProduct metaid="G_Ppat__45__Dpck" sboTerm="SBO:0000243" fbc:id="G_Ppat__45__Dpck" fbc:label="Ppat-Dpck"/>
       <fbc:geneProduct metaid="G_Ppcdc" sboTerm="SBO:0000243" fbc:id="G_Ppcdc" fbc:label="Ppcdc"/>
       <fbc:geneProduct metaid="G_Ppcs" sboTerm="SBO:0000243" fbc:id="G_Ppcs" fbc:label="Ppcs"/>
@@ -505389,7 +501856,6 @@
       <fbc:geneProduct metaid="G_Rchy1" sboTerm="SBO:0000243" fbc:id="G_Rchy1" fbc:label="Rchy1"/>
       <fbc:geneProduct metaid="G_RfC3" sboTerm="SBO:0000243" fbc:id="G_RfC3" fbc:label="RfC3"/>
       <fbc:geneProduct metaid="G_Rfk" sboTerm="SBO:0000243" fbc:id="G_Rfk" fbc:label="Rfk"/>
-      <fbc:geneProduct metaid="G_Rgl" sboTerm="SBO:0000243" fbc:id="G_Rgl" fbc:label="Rgl"/>
       <fbc:geneProduct metaid="G_RhoGAP92B" sboTerm="SBO:0000243" fbc:id="G_RhoGAP92B" fbc:label="RhoGAP92B"/>
       <fbc:geneProduct metaid="G_Rift" sboTerm="SBO:0000243" fbc:id="G_Rift" fbc:label="Rift"/>
       <fbc:geneProduct metaid="G_Rlip" sboTerm="SBO:0000243" fbc:id="G_Rlip" fbc:label="Rlip"/>
@@ -505408,7 +501874,6 @@
       <fbc:geneProduct metaid="G_SERCA" sboTerm="SBO:0000243" fbc:id="G_SERCA" fbc:label="SERCA"/>
       <fbc:geneProduct metaid="G_SLC22A" sboTerm="SBO:0000243" fbc:id="G_SLC22A" fbc:label="SLC22A"/>
       <fbc:geneProduct metaid="G_SPoCk" sboTerm="SBO:0000243" fbc:id="G_SPoCk" fbc:label="SPoCk"/>
-      <fbc:geneProduct metaid="G_SREBP" sboTerm="SBO:0000243" fbc:id="G_SREBP" fbc:label="SREBP"/>
       <fbc:geneProduct metaid="G_STUB1" sboTerm="SBO:0000243" fbc:id="G_STUB1" fbc:label="STUB1"/>
       <fbc:geneProduct metaid="G_Sac1" sboTerm="SBO:0000243" fbc:id="G_Sac1" fbc:label="Sac1"/>
       <fbc:geneProduct metaid="G_Sam__45__S" sboTerm="SBO:0000243" fbc:id="G_Sam__45__S" fbc:label="Sam-S"/>
@@ -505416,8 +501881,6 @@
       <fbc:geneProduct metaid="G_Sap__45__r" sboTerm="SBO:0000243" fbc:id="G_Sap__45__r" fbc:label="Sap-r"/>
       <fbc:geneProduct metaid="G_Sardh" sboTerm="SBO:0000243" fbc:id="G_Sardh" fbc:label="Sardh"/>
       <fbc:geneProduct metaid="G_Sc2" sboTerm="SBO:0000243" fbc:id="G_Sc2" fbc:label="Sc2"/>
-      <fbc:geneProduct metaid="G_Sccpdh1" sboTerm="SBO:0000243" fbc:id="G_Sccpdh1" fbc:label="Sccpdh1"/>
-      <fbc:geneProduct metaid="G_Sccpdh2" sboTerm="SBO:0000243" fbc:id="G_Sccpdh2" fbc:label="Sccpdh2"/>
       <fbc:geneProduct metaid="G_Sce" sboTerm="SBO:0000243" fbc:id="G_Sce" fbc:label="Sce"/>
       <fbc:geneProduct metaid="G_ScpX" sboTerm="SBO:0000243" fbc:id="G_ScpX" fbc:label="ScpX"/>
       <fbc:geneProduct metaid="G_Scs__945__1" sboTerm="SBO:0000243" fbc:id="G_Scs__945__1" fbc:label="Scsα1"/>
@@ -505439,7 +501902,6 @@
       <fbc:geneProduct metaid="G_Sgsh" sboTerm="SBO:0000243" fbc:id="G_Sgsh" fbc:label="Sgsh"/>
       <fbc:geneProduct metaid="G_Shmt" sboTerm="SBO:0000243" fbc:id="G_Shmt" fbc:label="Shmt"/>
       <fbc:geneProduct metaid="G_SiaT" sboTerm="SBO:0000243" fbc:id="G_SiaT" fbc:label="SiaT"/>
-      <fbc:geneProduct metaid="G_Sin3A" sboTerm="SBO:0000243" fbc:id="G_Sin3A" fbc:label="Sin3A"/>
       <fbc:geneProduct metaid="G_Sirt1" sboTerm="SBO:0000243" fbc:id="G_Sirt1" fbc:label="Sirt1"/>
       <fbc:geneProduct metaid="G_Sirt2" sboTerm="SBO:0000243" fbc:id="G_Sirt2" fbc:label="Sirt2"/>
       <fbc:geneProduct metaid="G_Sirt6" sboTerm="SBO:0000243" fbc:id="G_Sirt6" fbc:label="Sirt6"/>
@@ -505448,7 +501910,6 @@
       <fbc:geneProduct metaid="G_Sk2" sboTerm="SBO:0000243" fbc:id="G_Sk2" fbc:label="Sk2"/>
       <fbc:geneProduct metaid="G_Slip1" sboTerm="SBO:0000243" fbc:id="G_Slip1" fbc:label="Slip1"/>
       <fbc:geneProduct metaid="G_Sln" sboTerm="SBO:0000243" fbc:id="G_Sln" fbc:label="Sln"/>
-      <fbc:geneProduct metaid="G_Smr" sboTerm="SBO:0000243" fbc:id="G_Smr" fbc:label="Smr"/>
       <fbc:geneProduct metaid="G_Sms" sboTerm="SBO:0000243" fbc:id="G_Sms" fbc:label="Sms"/>
       <fbc:geneProduct metaid="G_Smurf" sboTerm="SBO:0000243" fbc:id="G_Smurf" fbc:label="Smurf"/>
       <fbc:geneProduct metaid="G_Smyd3" sboTerm="SBO:0000243" fbc:id="G_Smyd3" fbc:label="Smyd3"/>
@@ -505464,9 +501925,6 @@
       <fbc:geneProduct metaid="G_SpdS" sboTerm="SBO:0000243" fbc:id="G_SpdS" fbc:label="SpdS"/>
       <fbc:geneProduct metaid="G_Sply" sboTerm="SBO:0000243" fbc:id="G_Sply" fbc:label="Sply"/>
       <fbc:geneProduct metaid="G_Spn28Dc" sboTerm="SBO:0000243" fbc:id="G_Spn28Dc" fbc:label="Spn28Dc"/>
-      <fbc:geneProduct metaid="G_Spn77Bb" sboTerm="SBO:0000243" fbc:id="G_Spn77Bb" fbc:label="Spn77Bb"/>
-      <fbc:geneProduct metaid="G_Spn77Bc" sboTerm="SBO:0000243" fbc:id="G_Spn77Bc" fbc:label="Spn77Bc"/>
-      <fbc:geneProduct metaid="G_Spn85F" sboTerm="SBO:0000243" fbc:id="G_Spn85F" fbc:label="Spn85F"/>
       <fbc:geneProduct metaid="G_Sps1" sboTerm="SBO:0000243" fbc:id="G_Sps1" fbc:label="Sps1"/>
       <fbc:geneProduct metaid="G_Spt__45__I" sboTerm="SBO:0000243" fbc:id="G_Spt__45__I" fbc:label="Spt-I"/>
       <fbc:geneProduct metaid="G_Sptr" sboTerm="SBO:0000243" fbc:id="G_Sptr" fbc:label="Sptr"/>
@@ -505488,11 +501946,11 @@
       <fbc:geneProduct metaid="G_T3dh" sboTerm="SBO:0000243" fbc:id="G_T3dh" fbc:label="T3dh"/>
       <fbc:geneProduct metaid="G_Taf9" sboTerm="SBO:0000243" fbc:id="G_Taf9" fbc:label="Taf9"/>
       <fbc:geneProduct metaid="G_Taldo" sboTerm="SBO:0000243" fbc:id="G_Taldo" fbc:label="Taldo"/>
+      <fbc:geneProduct metaid="G_Targ1" sboTerm="SBO:0000243" fbc:id="G_Targ1" fbc:label="Targ1"/>
       <fbc:geneProduct metaid="G_Tat" sboTerm="SBO:0000243" fbc:id="G_Tat" fbc:label="Tat"/>
       <fbc:geneProduct metaid="G_Tbcb" sboTerm="SBO:0000243" fbc:id="G_Tbcb" fbc:label="Tbcb"/>
       <fbc:geneProduct metaid="G_Tbh" sboTerm="SBO:0000243" fbc:id="G_Tbh" fbc:label="Tbh"/>
       <fbc:geneProduct metaid="G_Tg" sboTerm="SBO:0000243" fbc:id="G_Tg" fbc:label="Tg"/>
-      <fbc:geneProduct metaid="G_Tgs1" sboTerm="SBO:0000243" fbc:id="G_Tgs1" fbc:label="Tgs1"/>
       <fbc:geneProduct metaid="G_Tgt" sboTerm="SBO:0000243" fbc:id="G_Tgt" fbc:label="Tgt"/>
       <fbc:geneProduct metaid="G_Thor" sboTerm="SBO:0000243" fbc:id="G_Thor" fbc:label="Thor"/>
       <fbc:geneProduct metaid="G_ThrRS" sboTerm="SBO:0000243" fbc:id="G_ThrRS" fbc:label="ThrRS"/>
@@ -505513,7 +501971,7 @@
       <fbc:geneProduct metaid="G_Trhn" sboTerm="SBO:0000243" fbc:id="G_Trhn" fbc:label="Trhn"/>
       <fbc:geneProduct metaid="G_Trm1" sboTerm="SBO:0000243" fbc:id="G_Trm1" fbc:label="Trm1"/>
       <fbc:geneProduct metaid="G_TrpRS" sboTerm="SBO:0000243" fbc:id="G_TrpRS" fbc:label="TrpRS"/>
-      <fbc:geneProduct metaid="G_Trx__45__2" sboTerm="SBO:0000243" fbc:id="G_Trx__45__2" fbc:label="Trx-2"/>
+      <fbc:geneProduct metaid="G_Trx2" sboTerm="SBO:0000243" fbc:id="G_Trx2" fbc:label="Trx2"/>
       <fbc:geneProduct metaid="G_Trxr1" sboTerm="SBO:0000243" fbc:id="G_Trxr1" fbc:label="Trxr1"/>
       <fbc:geneProduct metaid="G_Trxr2" sboTerm="SBO:0000243" fbc:id="G_Trxr2" fbc:label="Trxr2"/>
       <fbc:geneProduct metaid="G_Ts" sboTerm="SBO:0000243" fbc:id="G_Ts" fbc:label="Ts"/>
@@ -505675,7 +502133,6 @@
       <fbc:geneProduct metaid="G_eEF1__945__2" sboTerm="SBO:0000243" fbc:id="G_eEF1__945__2" fbc:label="eEF1α2"/>
       <fbc:geneProduct metaid="G_eEF2" sboTerm="SBO:0000243" fbc:id="G_eEF2" fbc:label="eEF2"/>
       <fbc:geneProduct metaid="G_eas" sboTerm="SBO:0000243" fbc:id="G_eas" fbc:label="eas"/>
-      <fbc:geneProduct metaid="G_ebi" sboTerm="SBO:0000243" fbc:id="G_ebi" fbc:label="ebi"/>
       <fbc:geneProduct metaid="G_ebo" sboTerm="SBO:0000243" fbc:id="G_ebo" fbc:label="ebo"/>
       <fbc:geneProduct metaid="G_eco" sboTerm="SBO:0000243" fbc:id="G_eco" fbc:label="eco"/>
       <fbc:geneProduct metaid="G_eff" sboTerm="SBO:0000243" fbc:id="G_eff" fbc:label="eff"/>
@@ -505691,7 +502148,6 @@
       <fbc:geneProduct metaid="G_fbp" sboTerm="SBO:0000243" fbc:id="G_fbp" fbc:label="fbp"/>
       <fbc:geneProduct metaid="G_fdl" sboTerm="SBO:0000243" fbc:id="G_fdl" fbc:label="fdl"/>
       <fbc:geneProduct metaid="G_fh" sboTerm="SBO:0000243" fbc:id="G_fh" fbc:label="fh"/>
-      <fbc:geneProduct metaid="G_flw" sboTerm="SBO:0000243" fbc:id="G_flw" fbc:label="flw"/>
       <fbc:geneProduct metaid="G_foi" sboTerm="SBO:0000243" fbc:id="G_foi" fbc:label="foi"/>
       <fbc:geneProduct metaid="G_frc" sboTerm="SBO:0000243" fbc:id="G_frc" fbc:label="frc"/>
       <fbc:geneProduct metaid="G_frj" sboTerm="SBO:0000243" fbc:id="G_frj" fbc:label="frj"/>
@@ -505762,6 +502218,7 @@
       <fbc:geneProduct metaid="G_mtm" sboTerm="SBO:0000243" fbc:id="G_mtm" fbc:label="mtm"/>
       <fbc:geneProduct metaid="G_muc" sboTerm="SBO:0000243" fbc:id="G_muc" fbc:label="muc"/>
       <fbc:geneProduct metaid="G_nSMase" sboTerm="SBO:0000243" fbc:id="G_nSMase" fbc:label="nSMase"/>
+      <fbc:geneProduct metaid="G_na" sboTerm="SBO:0000243" fbc:id="G_na" fbc:label="na"/>
       <fbc:geneProduct metaid="G_nac" sboTerm="SBO:0000243" fbc:id="G_nac" fbc:label="nac"/>
       <fbc:geneProduct metaid="G_nej" sboTerm="SBO:0000243" fbc:id="G_nej" fbc:label="nej"/>
       <fbc:geneProduct metaid="G_nes" sboTerm="SBO:0000243" fbc:id="G_nes" fbc:label="nes"/>
@@ -505780,6 +502237,7 @@
       <fbc:geneProduct metaid="G_oxt" sboTerm="SBO:0000243" fbc:id="G_oxt" fbc:label="oxt"/>
       <fbc:geneProduct metaid="G_oys" sboTerm="SBO:0000243" fbc:id="G_oys" fbc:label="oys"/>
       <fbc:geneProduct metaid="G_p23" sboTerm="SBO:0000243" fbc:id="G_p23" fbc:label="p23"/>
+      <fbc:geneProduct metaid="G_para" sboTerm="SBO:0000243" fbc:id="G_para" fbc:label="para"/>
       <fbc:geneProduct metaid="G_park" sboTerm="SBO:0000243" fbc:id="G_park" fbc:label="park"/>
       <fbc:geneProduct metaid="G_phm" sboTerm="SBO:0000243" fbc:id="G_phm" fbc:label="phm"/>
       <fbc:geneProduct metaid="G_phtm" sboTerm="SBO:0000243" fbc:id="G_phtm" fbc:label="phtm"/>
@@ -505789,6 +502247,8 @@
       <fbc:geneProduct metaid="G_pn" sboTerm="SBO:0000243" fbc:id="G_pn" fbc:label="pn"/>
       <fbc:geneProduct metaid="G_poe" sboTerm="SBO:0000243" fbc:id="G_poe" fbc:label="poe"/>
       <fbc:geneProduct metaid="G_por" sboTerm="SBO:0000243" fbc:id="G_por" fbc:label="por"/>
+      <fbc:geneProduct metaid="G_ppk11" sboTerm="SBO:0000243" fbc:id="G_ppk11" fbc:label="ppk11"/>
+      <fbc:geneProduct metaid="G_ppk22" sboTerm="SBO:0000243" fbc:id="G_ppk22" fbc:label="ppk22"/>
       <fbc:geneProduct metaid="G_ppl" sboTerm="SBO:0000243" fbc:id="G_ppl" fbc:label="ppl"/>
       <fbc:geneProduct metaid="G_pr" sboTerm="SBO:0000243" fbc:id="G_pr" fbc:label="pr"/>
       <fbc:geneProduct metaid="G_puf" sboTerm="SBO:0000243" fbc:id="G_puf" fbc:label="puf"/>
@@ -505809,7 +502269,6 @@
       <fbc:geneProduct metaid="G_sad" sboTerm="SBO:0000243" fbc:id="G_sad" fbc:label="sad"/>
       <fbc:geneProduct metaid="G_san" sboTerm="SBO:0000243" fbc:id="G_san" fbc:label="san"/>
       <fbc:geneProduct metaid="G_sbm" sboTerm="SBO:0000243" fbc:id="G_sbm" fbc:label="sbm"/>
-      <fbc:geneProduct metaid="G_sca" sboTerm="SBO:0000243" fbc:id="G_sca" fbc:label="sca"/>
       <fbc:geneProduct metaid="G_schlank" sboTerm="SBO:0000243" fbc:id="G_schlank" fbc:label="schlank"/>
       <fbc:geneProduct metaid="G_scny" sboTerm="SBO:0000243" fbc:id="G_scny" fbc:label="scny"/>
       <fbc:geneProduct metaid="G_scu" sboTerm="SBO:0000243" fbc:id="G_scu" fbc:label="scu"/>
@@ -505862,7 +502321,6 @@
       <fbc:geneProduct metaid="G_twr" sboTerm="SBO:0000243" fbc:id="G_twr" fbc:label="twr"/>
       <fbc:geneProduct metaid="G_tzn" sboTerm="SBO:0000243" fbc:id="G_tzn" fbc:label="tzn"/>
       <fbc:geneProduct metaid="G_upSET" sboTerm="SBO:0000243" fbc:id="G_upSET" fbc:label="upSET"/>
-      <fbc:geneProduct metaid="G_usp" sboTerm="SBO:0000243" fbc:id="G_usp" fbc:label="usp"/>
       <fbc:geneProduct metaid="G_v" sboTerm="SBO:0000243" fbc:id="G_v" fbc:label="v"/>
       <fbc:geneProduct metaid="G_vanin__45__like" sboTerm="SBO:0000243" fbc:id="G_vanin__45__like" fbc:label="vanin-like"/>
       <fbc:geneProduct metaid="G_veil" sboTerm="SBO:0000243" fbc:id="G_veil" fbc:label="veil"/>
@@ -506168,7 +502626,6 @@
           <groups:member groups:idRef="MAR03833"/>
           <groups:member groups:idRef="MAR03835"/>
           <groups:member groups:idRef="MAR03837"/>
-          <groups:member groups:idRef="MAR03838"/>
           <groups:member groups:idRef="MAR03895"/>
           <groups:member groups:idRef="MAR03897"/>
           <groups:member groups:idRef="MAR03956"/>
@@ -506317,15 +502774,12 @@
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group14" groups:name="Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)" groups:kind="partonomy">
         <groups:listOfMembers>
-          <groups:member groups:idRef="MAR03301"/>
           <groups:member groups:idRef="MAR03302"/>
           <groups:member groups:idRef="MAR03304"/>
           <groups:member groups:idRef="MAR03305"/>
-          <groups:member groups:idRef="MAR03306"/>
           <groups:member groups:idRef="MAR03307"/>
           <groups:member groups:idRef="MAR03309"/>
           <groups:member groups:idRef="MAR03310"/>
-          <groups:member groups:idRef="MAR03311"/>
           <groups:member groups:idRef="MAR03312"/>
           <groups:member groups:idRef="MAR03314"/>
           <groups:member groups:idRef="MAR03315"/>
@@ -506335,6 +502789,9 @@
           <groups:member groups:idRef="MAR03320"/>
           <groups:member groups:idRef="MAR03321"/>
           <groups:member groups:idRef="MAR03323"/>
+          <groups:member groups:idRef="MAR02804"/>
+          <groups:member groups:idRef="MAR02808"/>
+          <groups:member groups:idRef="MAR02810"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group15" groups:name="Beta oxidation of even-chain fatty acids (mitochondrial)" groups:kind="partonomy">
@@ -506631,15 +503088,15 @@
           <groups:member groups:idRef="MAR03352"/>
           <groups:member groups:idRef="MAR03353"/>
           <groups:member groups:idRef="MAR03355"/>
-          <groups:member groups:idRef="MAR03364"/>
           <groups:member groups:idRef="MAR03365"/>
           <groups:member groups:idRef="MAR03367"/>
           <groups:member groups:idRef="MAR03368"/>
-          <groups:member groups:idRef="MAR03369"/>
           <groups:member groups:idRef="MAR03370"/>
           <groups:member groups:idRef="MAR03372"/>
           <groups:member groups:idRef="MAR03373"/>
           <groups:member groups:idRef="MAR03375"/>
+          <groups:member groups:idRef="MAR03276"/>
+          <groups:member groups:idRef="MAR03289"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group25" groups:name="Beta-alanine metabolism" groups:kind="partonomy">
@@ -506673,14 +503130,10 @@
           <groups:member groups:idRef="MAR01613"/>
           <groups:member groups:idRef="MAR01614"/>
           <groups:member groups:idRef="MAR01632"/>
-          <groups:member groups:idRef="MAR01635"/>
-          <groups:member groups:idRef="MAR01637"/>
           <groups:member groups:idRef="MAR01638"/>
-          <groups:member groups:idRef="MAR01639"/>
           <groups:member groups:idRef="MAR01642"/>
           <groups:member groups:idRef="MAR01646"/>
           <groups:member groups:idRef="MAR01652"/>
-          <groups:member groups:idRef="MAR01653"/>
           <groups:member groups:idRef="MAR01659"/>
           <groups:member groups:idRef="MAR01673"/>
           <groups:member groups:idRef="MAR01676"/>
@@ -506753,12 +503206,10 @@
           <groups:member groups:idRef="MAR08064"/>
           <groups:member groups:idRef="MAR08065"/>
           <groups:member groups:idRef="MAR08759"/>
-          <groups:member groups:idRef="MAR00059"/>
           <groups:member groups:idRef="MAR00069"/>
           <groups:member groups:idRef="MAR00070"/>
           <groups:member groups:idRef="MAR00071"/>
           <groups:member groups:idRef="MAR01456"/>
-          <groups:member groups:idRef="MAR01458"/>
           <groups:member groups:idRef="MAR01567"/>
           <groups:member groups:idRef="MAR01711"/>
           <groups:member groups:idRef="MAR02184"/>
@@ -506941,8 +503392,6 @@
           <groups:member groups:idRef="MAR07669"/>
           <groups:member groups:idRef="MAR07670"/>
           <groups:member groups:idRef="MAR07671"/>
-          <groups:member groups:idRef="MAR07672"/>
-          <groups:member groups:idRef="MAR07673"/>
           <groups:member groups:idRef="MAR00073"/>
           <groups:member groups:idRef="MAR00074"/>
           <groups:member groups:idRef="MAR00086"/>
@@ -507354,6 +503803,7 @@
       <groups:group sboTerm="SBO:0000633" groups:id="group39" groups:name="Cholesterol biosynthesis 2" groups:kind="partonomy">
         <groups:listOfMembers>
           <groups:member groups:idRef="MAR01565"/>
+          <groups:member groups:idRef="MAR01557"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group40" groups:name="Cholesterol biosynthesis 3 (Kandustch-Russell pathway)" groups:kind="partonomy">
@@ -507406,15 +503856,14 @@
           <groups:member groups:idRef="MAR09947"/>
           <groups:member groups:idRef="MAR11408"/>
           <groups:member groups:idRef="MAR11506"/>
-          <groups:member groups:idRef="MAR00113"/>
-          <groups:member groups:idRef="MAR00222"/>
-          <groups:member groups:idRef="MAR00443"/>
+          <groups:member groups:idRef="MAR00114"/>
           <groups:member groups:idRef="MAR01498"/>
-          <groups:member groups:idRef="MAR01508"/>
           <groups:member groups:idRef="MAR01714"/>
           <groups:member groups:idRef="MAR01715"/>
           <groups:member groups:idRef="MAR02200"/>
           <groups:member groups:idRef="MAR02301"/>
+          <groups:member groups:idRef="MAR02337"/>
+          <groups:member groups:idRef="MAR02339"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group42" groups:name="Chondroitin / heparan sulfate biosynthesis" groups:kind="partonomy">
@@ -507547,7 +503996,6 @@
           <groups:member groups:idRef="MAR08683"/>
           <groups:member groups:idRef="MAR08684"/>
           <groups:member groups:idRef="MAR08685"/>
-          <groups:member groups:idRef="MAR02027"/>
           <groups:member groups:idRef="MAR08974"/>
           <groups:member groups:idRef="MAR08993"/>
           <groups:member groups:idRef="MAR09953"/>
@@ -508747,7 +505195,6 @@
           <groups:member groups:idRef="MAR00655"/>
           <groups:member groups:idRef="MAR00656"/>
           <groups:member groups:idRef="MAR00658"/>
-          <groups:member groups:idRef="MAR00659"/>
           <groups:member groups:idRef="MAR00661"/>
           <groups:member groups:idRef="MAR00662"/>
           <groups:member groups:idRef="MAR00666"/>
@@ -508805,7 +505252,6 @@
           <groups:member groups:idRef="MAR04138"/>
           <groups:member groups:idRef="MAR04140"/>
           <groups:member groups:idRef="MAR04142"/>
-          <groups:member groups:idRef="MAR04144"/>
           <groups:member groups:idRef="MAR04146"/>
           <groups:member groups:idRef="MAR04148"/>
           <groups:member groups:idRef="MAR04150"/>
@@ -509184,7 +505630,6 @@
           <groups:member groups:idRef="MAR10430"/>
           <groups:member groups:idRef="MAR10431"/>
           <groups:member groups:idRef="MAR10432"/>
-          <groups:member groups:idRef="MAR10433"/>
           <groups:member groups:idRef="MAR10434"/>
           <groups:member groups:idRef="MAR10435"/>
           <groups:member groups:idRef="MAR10436"/>
@@ -509884,7 +506329,6 @@
           <groups:member groups:idRef="MAR13061"/>
           <groups:member groups:idRef="MAR13062"/>
           <groups:member groups:idRef="MAR13063"/>
-          <groups:member groups:idRef="MAR13064"/>
           <groups:member groups:idRef="MAR13065"/>
           <groups:member groups:idRef="MAR13067"/>
           <groups:member groups:idRef="MAR13068"/>
@@ -509895,7 +506339,6 @@
           <groups:member groups:idRef="MAR13073"/>
           <groups:member groups:idRef="MAR13074"/>
           <groups:member groups:idRef="MAR10024"/>
-          <groups:member groups:idRef="MAR10025"/>
           <groups:member groups:idRef="MAR10026"/>
           <groups:member groups:idRef="MAR10027"/>
           <groups:member groups:idRef="MAR10028"/>
@@ -510071,7 +506514,6 @@
           <groups:member groups:idRef="MAR01032"/>
           <groups:member groups:idRef="MAR01036"/>
           <groups:member groups:idRef="MAR01471"/>
-          <groups:member groups:idRef="MAR02185"/>
           <groups:member groups:idRef="MAR02322"/>
           <groups:member groups:idRef="MAR02323"/>
           <groups:member groups:idRef="MAR02325"/>
@@ -510102,8 +506544,7 @@
           <groups:member groups:idRef="MAR03745"/>
           <groups:member groups:idRef="MAR03749"/>
           <groups:member groups:idRef="MAR11305"/>
-          <groups:member groups:idRef="MAR00145"/>
-          <groups:member groups:idRef="MAR00151"/>
+          <groups:member groups:idRef="MAR00149"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group54" groups:name="Fatty acid biosynthesis (even-chain)" groups:kind="partonomy">
@@ -510136,8 +506577,10 @@
           <groups:member groups:idRef="MAR02179"/>
           <groups:member groups:idRef="MAR02180"/>
           <groups:member groups:idRef="MAR02181"/>
-          <groups:member groups:idRef="MAR04156"/>
           <groups:member groups:idRef="MAR04295"/>
+          <groups:member groups:idRef="MAR07672"/>
+          <groups:member groups:idRef="MAR07673"/>
+          <groups:member groups:idRef="MAR20112"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group55" groups:name="Fatty acid biosynthesis (odd-chain)" groups:kind="partonomy">
@@ -510391,7 +506834,6 @@
           <groups:member groups:idRef="MAR01799"/>
           <groups:member groups:idRef="MAR01814"/>
           <groups:member groups:idRef="MAR02028"/>
-          <groups:member groups:idRef="MAR02035"/>
           <groups:member groups:idRef="MAR02121"/>
           <groups:member groups:idRef="MAR02122"/>
           <groups:member groups:idRef="MAR02123"/>
@@ -510405,18 +506847,10 @@
           <groups:member groups:idRef="MAR02313"/>
           <groups:member groups:idRef="MAR02314"/>
           <groups:member groups:idRef="MAR02340"/>
-          <groups:member groups:idRef="MAR02367"/>
-          <groups:member groups:idRef="MAR02369"/>
-          <groups:member groups:idRef="MAR02370"/>
-          <groups:member groups:idRef="MAR02372"/>
-          <groups:member groups:idRef="MAR02373"/>
           <groups:member groups:idRef="MAR02381"/>
           <groups:member groups:idRef="MAR02492"/>
           <groups:member groups:idRef="MAR02786"/>
           <groups:member groups:idRef="MAR02802"/>
-          <groups:member groups:idRef="MAR02804"/>
-          <groups:member groups:idRef="MAR02808"/>
-          <groups:member groups:idRef="MAR02810"/>
           <groups:member groups:idRef="MAR02818"/>
           <groups:member groups:idRef="MAR02820"/>
           <groups:member groups:idRef="MAR02826"/>
@@ -510428,8 +506862,6 @@
           <groups:member groups:idRef="MAR03270"/>
           <groups:member groups:idRef="MAR03273"/>
           <groups:member groups:idRef="MAR03274"/>
-          <groups:member groups:idRef="MAR03276"/>
-          <groups:member groups:idRef="MAR03289"/>
           <groups:member groups:idRef="MAR03291"/>
           <groups:member groups:idRef="MAR03295"/>
           <groups:member groups:idRef="MAR03297"/>
@@ -510463,7 +506895,6 @@
           <groups:member groups:idRef="MAR03438"/>
           <groups:member groups:idRef="MAR03439"/>
           <groups:member groups:idRef="MAR03440"/>
-          <groups:member groups:idRef="MAR03441"/>
           <groups:member groups:idRef="MAR03442"/>
           <groups:member groups:idRef="MAR03443"/>
           <groups:member groups:idRef="MAR03451"/>
@@ -510486,9 +506917,7 @@
           <groups:member groups:idRef="MAR03516"/>
           <groups:member groups:idRef="MAR03518"/>
           <groups:member groups:idRef="MAR03535"/>
-          <groups:member groups:idRef="MAR03754"/>
           <groups:member groups:idRef="MAR03758"/>
-          <groups:member groups:idRef="MAR03760"/>
           <groups:member groups:idRef="MAR03764"/>
           <groups:member groups:idRef="MAR03997"/>
           <groups:member groups:idRef="MAR04001"/>
@@ -510505,7 +506934,6 @@
           <groups:member groups:idRef="MAR04479"/>
           <groups:member groups:idRef="MAR04491"/>
           <groups:member groups:idRef="MAR04504"/>
-          <groups:member groups:idRef="MAR04506"/>
           <groups:member groups:idRef="MAR04508"/>
           <groups:member groups:idRef="MAR04511"/>
           <groups:member groups:idRef="MAR04515"/>
@@ -510539,7 +506967,6 @@
           <groups:member groups:idRef="MAR04807"/>
           <groups:member groups:idRef="MAR04809"/>
           <groups:member groups:idRef="MAR04813"/>
-          <groups:member groups:idRef="MAR04966"/>
           <groups:member groups:idRef="MAR04967"/>
           <groups:member groups:idRef="MAR04968"/>
           <groups:member groups:idRef="MAR04978"/>
@@ -511156,7 +507583,6 @@
           <groups:member groups:idRef="MAR00478"/>
           <groups:member groups:idRef="MAR00479"/>
           <groups:member groups:idRef="MAR00481"/>
-          <groups:member groups:idRef="MAR00483"/>
           <groups:member groups:idRef="MAR00482"/>
           <groups:member groups:idRef="MAR00579"/>
           <groups:member groups:idRef="MAR00580"/>
@@ -511453,7 +507879,7 @@
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group78" groups:name="Glyoxylate and dicarboxylate metabolism" groups:kind="partonomy">
         <groups:listOfMembers>
-          <groups:member groups:idRef="MAR20066"/>
+          <groups:member groups:idRef="MAR03984"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group79" groups:name="Heme degradation" groups:kind="partonomy">
@@ -511653,7 +508079,6 @@
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group88" groups:name="Isolated" groups:kind="partonomy">
         <groups:listOfMembers>
-          <groups:member groups:idRef="MAR00024"/>
           <groups:member groups:idRef="MAR08643"/>
           <groups:member groups:idRef="MAR08645"/>
           <groups:member groups:idRef="MAR01403"/>
@@ -512190,7 +508615,6 @@
         <groups:listOfMembers>
           <groups:member groups:idRef="MAR05407"/>
           <groups:member groups:idRef="MAR03955"/>
-          <groups:member groups:idRef="MAR03984"/>
           <groups:member groups:idRef="MAR04201"/>
           <groups:member groups:idRef="MAR04202"/>
           <groups:member groups:idRef="MAR05127"/>
@@ -512215,8 +508639,6 @@
           <groups:member groups:idRef="MAR02341"/>
           <groups:member groups:idRef="MAR02352"/>
           <groups:member groups:idRef="MAR02357"/>
-          <groups:member groups:idRef="MAR02358"/>
-          <groups:member groups:idRef="MAR02366"/>
           <groups:member groups:idRef="MAR02375"/>
           <groups:member groups:idRef="MAR02529"/>
           <groups:member groups:idRef="MAR02531"/>
@@ -512261,6 +508683,7 @@
           <groups:member groups:idRef="MAR12126"/>
           <groups:member groups:idRef="MAR10070"/>
           <groups:member groups:idRef="MAR20110"/>
+          <groups:member groups:idRef="MAR20114"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group97" groups:name="N-glycan metabolism" groups:kind="partonomy">
@@ -512575,6 +508998,7 @@
           <groups:member groups:idRef="MAR02583"/>
           <groups:member groups:idRef="MAR02584"/>
           <groups:member groups:idRef="MAR02587"/>
+          <groups:member groups:idRef="MAR02472"/>
           <groups:member groups:idRef="MAR02505"/>
         </groups:listOfMembers>
       </groups:group>
@@ -512996,7 +509420,6 @@
           <groups:member groups:idRef="MAR04232"/>
           <groups:member groups:idRef="MAR04233"/>
           <groups:member groups:idRef="MAR04235"/>
-          <groups:member groups:idRef="MAR04242"/>
           <groups:member groups:idRef="MAR04243"/>
           <groups:member groups:idRef="MAR04244"/>
           <groups:member groups:idRef="MAR04245"/>
@@ -513157,7 +509580,6 @@
           <groups:member groups:idRef="MAR05257"/>
           <groups:member groups:idRef="MAR09022"/>
           <groups:member groups:idRef="MAR00031"/>
-          <groups:member groups:idRef="MAR00032"/>
           <groups:member groups:idRef="MAR10033"/>
           <groups:member groups:idRef="MAR10034"/>
           <groups:member groups:idRef="MAR10035"/>
@@ -513216,7 +509638,7 @@
           <groups:member groups:idRef="MAR11486"/>
           <groups:member groups:idRef="MAR11487"/>
           <groups:member groups:idRef="MAR11489"/>
-          <groups:member groups:idRef="MAR04497"/>
+          <groups:member groups:idRef="MAR04106"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group115" groups:name="Prostaglandin biosynthesis" groups:kind="partonomy">
@@ -513298,7 +509720,6 @@
           <groups:member groups:idRef="MAR05170"/>
           <groups:member groups:idRef="MAR05171"/>
           <groups:member groups:idRef="MAR05172"/>
-          <groups:member groups:idRef="MAR05173"/>
           <groups:member groups:idRef="MAR05174"/>
           <groups:member groups:idRef="MAR13078"/>
           <groups:member groups:idRef="MAR05151"/>
@@ -513336,7 +509757,6 @@
           <groups:member groups:idRef="MAR05286"/>
           <groups:member groups:idRef="MAR05287"/>
           <groups:member groups:idRef="MAR05288"/>
-          <groups:member groups:idRef="MAR05289"/>
           <groups:member groups:idRef="MAR05290"/>
           <groups:member groups:idRef="MAR05291"/>
           <groups:member groups:idRef="MAR09817"/>
@@ -513471,7 +509891,6 @@
           <groups:member groups:idRef="MAR06616"/>
           <groups:member groups:idRef="MAR04635"/>
           <groups:member groups:idRef="MAR03793"/>
-          <groups:member groups:idRef="MAR03931"/>
           <groups:member groups:idRef="MAR03969"/>
           <groups:member groups:idRef="MAR03970"/>
           <groups:member groups:idRef="MAR04008"/>
@@ -513524,11 +509943,12 @@
           <groups:member groups:idRef="MAR06627"/>
           <groups:member groups:idRef="MAR08072"/>
           <groups:member groups:idRef="MAR08637"/>
-          <groups:member groups:idRef="MAR00096"/>
           <groups:member groups:idRef="MAR02120"/>
           <groups:member groups:idRef="MAR08274"/>
           <groups:member groups:idRef="MAR11398"/>
           <groups:member groups:idRef="MAR15013"/>
+          <groups:member groups:idRef="MAR03931"/>
+          <groups:member groups:idRef="MAR04485"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group121" groups:name="Pyruvate metabolism" groups:kind="partonomy">
@@ -513639,7 +510059,6 @@
           <groups:member groups:idRef="MAR08713"/>
           <groups:member groups:idRef="MAR08717"/>
           <groups:member groups:idRef="MAR20001"/>
-          <groups:member groups:idRef="MAR20002"/>
           <groups:member groups:idRef="MAR20003"/>
           <groups:member groups:idRef="MAR20005"/>
           <groups:member groups:idRef="MAR20006"/>
@@ -513798,14 +510217,11 @@
           <groups:member groups:idRef="MAR00072"/>
           <groups:member groups:idRef="MAR01380"/>
           <groups:member groups:idRef="MAR01812"/>
-          <groups:member groups:idRef="MAR20020"/>
           <groups:member groups:idRef="MAR15052"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group128" groups:name="Steroid metabolism" groups:kind="partonomy">
         <groups:listOfMembers>
-          <groups:member groups:idRef="MAR01644"/>
-          <groups:member groups:idRef="MAR01651"/>
           <groups:member groups:idRef="MAR01924"/>
           <groups:member groups:idRef="MAR01926"/>
           <groups:member groups:idRef="MAR01927"/>
@@ -513925,17 +510341,10 @@
           <groups:member groups:idRef="MAR03478"/>
           <groups:member groups:idRef="MAR03481"/>
           <groups:member groups:idRef="MAR03517"/>
-          <groups:member groups:idRef="MAR00025"/>
-          <groups:member groups:idRef="MAR00026"/>
-          <groups:member groups:idRef="MAR00027"/>
-          <groups:member groups:idRef="MAR00028"/>
-          <groups:member groups:idRef="MAR00029"/>
-          <groups:member groups:idRef="MAR00030"/>
           <groups:member groups:idRef="MAR01592"/>
           <groups:member groups:idRef="MAR01593"/>
           <groups:member groups:idRef="MAR01622"/>
           <groups:member groups:idRef="MAR01623"/>
-          <groups:member groups:idRef="MAR01656"/>
           <groups:member groups:idRef="MAR01679"/>
           <groups:member groups:idRef="MAR01694"/>
           <groups:member groups:idRef="MAR01695"/>
@@ -514904,9 +511313,6 @@
           <groups:member groups:idRef="MAR06139"/>
           <groups:member groups:idRef="MAR06140"/>
           <groups:member groups:idRef="MAR06141"/>
-          <groups:member groups:idRef="MAR06142"/>
-          <groups:member groups:idRef="MAR06143"/>
-          <groups:member groups:idRef="MAR06144"/>
           <groups:member groups:idRef="MAR06145"/>
           <groups:member groups:idRef="MAR06146"/>
           <groups:member groups:idRef="MAR06147"/>
@@ -514982,7 +511388,6 @@
           <groups:member groups:idRef="MAR06217"/>
           <groups:member groups:idRef="MAR06218"/>
           <groups:member groups:idRef="MAR06219"/>
-          <groups:member groups:idRef="MAR06220"/>
           <groups:member groups:idRef="MAR06221"/>
           <groups:member groups:idRef="MAR06222"/>
           <groups:member groups:idRef="MAR06223"/>
@@ -515014,7 +511419,6 @@
           <groups:member groups:idRef="MAR06249"/>
           <groups:member groups:idRef="MAR06250"/>
           <groups:member groups:idRef="MAR06251"/>
-          <groups:member groups:idRef="MAR06252"/>
           <groups:member groups:idRef="MAR06253"/>
           <groups:member groups:idRef="MAR06254"/>
           <groups:member groups:idRef="MAR06255"/>
@@ -515660,7 +512064,6 @@
           <groups:member groups:idRef="MAR07719"/>
           <groups:member groups:idRef="MAR07723"/>
           <groups:member groups:idRef="MAR07757"/>
-          <groups:member groups:idRef="MAR07758"/>
           <groups:member groups:idRef="MAR07760"/>
           <groups:member groups:idRef="MAR07769"/>
           <groups:member groups:idRef="MAR07804"/>
@@ -516480,7 +512883,6 @@
           <groups:member groups:idRef="MAR01597"/>
           <groups:member groups:idRef="MAR01601"/>
           <groups:member groups:idRef="MAR01607"/>
-          <groups:member groups:idRef="MAR01617"/>
           <groups:member groups:idRef="MAR01626"/>
           <groups:member groups:idRef="MAR01633"/>
           <groups:member groups:idRef="MAR01636"/>
@@ -516502,7 +512904,6 @@
           <groups:member groups:idRef="MAR01698"/>
           <groups:member groups:idRef="MAR01705"/>
           <groups:member groups:idRef="MAR01707"/>
-          <groups:member groups:idRef="MAR01709"/>
           <groups:member groups:idRef="MAR01712"/>
           <groups:member groups:idRef="MAR01719"/>
           <groups:member groups:idRef="MAR01728"/>
@@ -516520,7 +512921,6 @@
           <groups:member groups:idRef="MAR01795"/>
           <groups:member groups:idRef="MAR01821"/>
           <groups:member groups:idRef="MAR01822"/>
-          <groups:member groups:idRef="MAR01823"/>
           <groups:member groups:idRef="MAR01824"/>
           <groups:member groups:idRef="MAR01825"/>
           <groups:member groups:idRef="MAR01826"/>
@@ -516544,8 +512944,6 @@
           <groups:member groups:idRef="MAR02273"/>
           <groups:member groups:idRef="MAR02274"/>
           <groups:member groups:idRef="MAR02275"/>
-          <groups:member groups:idRef="MAR02276"/>
-          <groups:member groups:idRef="MAR02277"/>
           <groups:member groups:idRef="MAR02278"/>
           <groups:member groups:idRef="MAR02279"/>
           <groups:member groups:idRef="MAR02280"/>
@@ -516571,9 +512969,6 @@
           <groups:member groups:idRef="MAR02379"/>
           <groups:member groups:idRef="MAR02382"/>
           <groups:member groups:idRef="MAR02388"/>
-          <groups:member groups:idRef="MAR02390"/>
-          <groups:member groups:idRef="MAR02392"/>
-          <groups:member groups:idRef="MAR02394"/>
           <groups:member groups:idRef="MAR02396"/>
           <groups:member groups:idRef="MAR02398"/>
           <groups:member groups:idRef="MAR02400"/>
@@ -516757,7 +513152,6 @@
           <groups:member groups:idRef="MAR09884"/>
           <groups:member groups:idRef="MAR09885"/>
           <groups:member groups:idRef="MAR09886"/>
-          <groups:member groups:idRef="MAR09887"/>
           <groups:member groups:idRef="MAR09888"/>
           <groups:member groups:idRef="MAR09889"/>
           <groups:member groups:idRef="MAR09891"/>
@@ -516882,7 +513276,6 @@
           <groups:member groups:idRef="MAR10161"/>
           <groups:member groups:idRef="MAR10162"/>
           <groups:member groups:idRef="MAR10163"/>
-          <groups:member groups:idRef="MAR10164"/>
           <groups:member groups:idRef="MAR10165"/>
           <groups:member groups:idRef="MAR10166"/>
           <groups:member groups:idRef="MAR10167"/>
@@ -516954,7 +513347,6 @@
           <groups:member groups:idRef="MAR10421"/>
           <groups:member groups:idRef="MAR10423"/>
           <groups:member groups:idRef="MAR10425"/>
-          <groups:member groups:idRef="MAR10447"/>
           <groups:member groups:idRef="MAR10453"/>
           <groups:member groups:idRef="MAR10454"/>
           <groups:member groups:idRef="MAR10455"/>
@@ -516963,11 +513355,8 @@
           <groups:member groups:idRef="MAR10464"/>
           <groups:member groups:idRef="MAR10465"/>
           <groups:member groups:idRef="MAR10466"/>
-          <groups:member groups:idRef="MAR10467"/>
           <groups:member groups:idRef="MAR10468"/>
-          <groups:member groups:idRef="MAR10469"/>
           <groups:member groups:idRef="MAR10470"/>
-          <groups:member groups:idRef="MAR10471"/>
           <groups:member groups:idRef="MAR10479"/>
           <groups:member groups:idRef="MAR10480"/>
           <groups:member groups:idRef="MAR10481"/>
@@ -517487,10 +513876,6 @@
           <groups:member groups:idRef="MAR11646"/>
           <groups:member groups:idRef="MAR11647"/>
           <groups:member groups:idRef="MAR11648"/>
-          <groups:member groups:idRef="MAR11649"/>
-          <groups:member groups:idRef="MAR11650"/>
-          <groups:member groups:idRef="MAR11651"/>
-          <groups:member groups:idRef="MAR11652"/>
           <groups:member groups:idRef="MAR11653"/>
           <groups:member groups:idRef="MAR11654"/>
           <groups:member groups:idRef="MAR11655"/>
@@ -517535,39 +513920,22 @@
           <groups:member groups:idRef="MAR11694"/>
           <groups:member groups:idRef="MAR11695"/>
           <groups:member groups:idRef="MAR11696"/>
-          <groups:member groups:idRef="MAR11697"/>
           <groups:member groups:idRef="MAR11698"/>
-          <groups:member groups:idRef="MAR11699"/>
           <groups:member groups:idRef="MAR11700"/>
-          <groups:member groups:idRef="MAR11701"/>
           <groups:member groups:idRef="MAR11702"/>
-          <groups:member groups:idRef="MAR11703"/>
           <groups:member groups:idRef="MAR11704"/>
-          <groups:member groups:idRef="MAR11705"/>
           <groups:member groups:idRef="MAR11706"/>
-          <groups:member groups:idRef="MAR11707"/>
           <groups:member groups:idRef="MAR11708"/>
-          <groups:member groups:idRef="MAR11709"/>
           <groups:member groups:idRef="MAR11710"/>
-          <groups:member groups:idRef="MAR11711"/>
           <groups:member groups:idRef="MAR11712"/>
-          <groups:member groups:idRef="MAR11713"/>
           <groups:member groups:idRef="MAR11714"/>
-          <groups:member groups:idRef="MAR11715"/>
           <groups:member groups:idRef="MAR11716"/>
-          <groups:member groups:idRef="MAR11717"/>
           <groups:member groups:idRef="MAR11718"/>
-          <groups:member groups:idRef="MAR11719"/>
           <groups:member groups:idRef="MAR11720"/>
-          <groups:member groups:idRef="MAR11721"/>
           <groups:member groups:idRef="MAR11722"/>
-          <groups:member groups:idRef="MAR11723"/>
           <groups:member groups:idRef="MAR11724"/>
-          <groups:member groups:idRef="MAR11725"/>
           <groups:member groups:idRef="MAR11726"/>
-          <groups:member groups:idRef="MAR11727"/>
           <groups:member groups:idRef="MAR11728"/>
-          <groups:member groups:idRef="MAR11729"/>
           <groups:member groups:idRef="MAR11731"/>
           <groups:member groups:idRef="MAR11733"/>
           <groups:member groups:idRef="MAR11734"/>
@@ -517710,15 +514078,10 @@
           <groups:member groups:idRef="MAR11980"/>
           <groups:member groups:idRef="MAR11981"/>
           <groups:member groups:idRef="MAR11986"/>
-          <groups:member groups:idRef="MAR11988"/>
           <groups:member groups:idRef="MAR11989"/>
-          <groups:member groups:idRef="MAR11991"/>
           <groups:member groups:idRef="MAR11992"/>
-          <groups:member groups:idRef="MAR11994"/>
           <groups:member groups:idRef="MAR11995"/>
-          <groups:member groups:idRef="MAR11997"/>
           <groups:member groups:idRef="MAR11998"/>
-          <groups:member groups:idRef="MAR12000"/>
           <groups:member groups:idRef="MAR12006"/>
           <groups:member groups:idRef="MAR12008"/>
           <groups:member groups:idRef="MAR12010"/>
@@ -517914,6 +514277,7 @@
           <groups:member groups:idRef="MAR13084"/>
           <groups:member groups:idRef="MAR13085"/>
           <groups:member groups:idRef="MAR13086"/>
+          <groups:member groups:idRef="MAR20113"/>
           <groups:member groups:idRef="MAR04861"/>
           <groups:member groups:idRef="MAR08614"/>
         </groups:listOfMembers>
@@ -517946,7 +514310,6 @@
           <groups:member groups:idRef="MAR06414"/>
           <groups:member groups:idRef="MAR07704"/>
           <groups:member groups:idRef="MAR07706"/>
-          <groups:member groups:idRef="MAR08743"/>
           <groups:member groups:idRef="MAR08772"/>
           <groups:member groups:idRef="MAR08773"/>
           <groups:member groups:idRef="MAR08774"/>
@@ -518006,7 +514369,6 @@
           <groups:member groups:idRef="MAR08543"/>
           <groups:member groups:idRef="MAR08544"/>
           <groups:member groups:idRef="MAR08540"/>
-          <groups:member groups:idRef="MAR09733"/>
           <groups:member groups:idRef="MAR02615"/>
           <groups:member groups:idRef="MAR02617"/>
           <groups:member groups:idRef="MAR02619"/>
@@ -518072,7 +514434,6 @@
       <groups:group sboTerm="SBO:0000633" groups:id="group142" groups:name="Valine, leucine, and isoleucine metabolism" groups:kind="partonomy">
         <groups:listOfMembers>
           <groups:member groups:idRef="MAR03206"/>
-          <groups:member groups:idRef="MAR03211"/>
           <groups:member groups:idRef="MAR03747"/>
           <groups:member groups:idRef="MAR03744"/>
           <groups:member groups:idRef="MAR03757"/>
@@ -518093,24 +514454,19 @@
           <groups:member groups:idRef="MAR06927"/>
           <groups:member groups:idRef="MAR08088"/>
           <groups:member groups:idRef="MAR03748"/>
-          <groups:member groups:idRef="MAR03751"/>
           <groups:member groups:idRef="MAR03753"/>
           <groups:member groups:idRef="MAR03755"/>
           <groups:member groups:idRef="MAR03759"/>
           <groups:member groups:idRef="MAR03763"/>
-          <groups:member groups:idRef="MAR03767"/>
-          <groups:member groups:idRef="MAR03769"/>
           <groups:member groups:idRef="MAR03773"/>
           <groups:member groups:idRef="MAR03775"/>
           <groups:member groups:idRef="MAR03780"/>
-          <groups:member groups:idRef="MAR03783"/>
           <groups:member groups:idRef="MAR03785"/>
           <groups:member groups:idRef="MAR03790"/>
           <groups:member groups:idRef="MAR03792"/>
           <groups:member groups:idRef="MAR03796"/>
           <groups:member groups:idRef="MAR03823"/>
           <groups:member groups:idRef="MAR06416"/>
-          <groups:member groups:idRef="MAR00042"/>
           <groups:member groups:idRef="MAR02146"/>
           <groups:member groups:idRef="MAR09941"/>
           <groups:member groups:idRef="MAR10412"/>
diff --git a/model/Fruitfly-GEM.yml b/model/Fruitfly-GEM.yml
index ddc3cc3..182b050 100644
--- a/model/Fruitfly-GEM.yml
+++ b/model/Fruitfly-GEM.yml
@@ -4,7 +4,7 @@
     short_name: "Fruitfly-GEM"
     full_name: ""
     version: ""
-    date: "2023-08-16"
+    date: "2023-10-01"
     taxonomy: ""
     github: ""
     description: ""
@@ -548,13 +548,6 @@
       - formula: "C20H29O3"
       - charge: -1
       - inchis: ""
-    - !!omap
-      - id: "MAM00029c"
-      - name: "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoic acid"
-      - compartment: "c"
-      - formula: "C20H29O3"
-      - charge: -1
-      - inchis: ""
     - !!omap
       - id: "MAM00030c"
       - name: "(1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol"
@@ -618,13 +611,6 @@
       - formula: "C27H44O3"
       - charge: 0
       - inchis: ""
-    - !!omap
-      - id: "MAM00036m"
-      - name: "(24R,25R)3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA"
-      - compartment: "m"
-      - formula: "C48H76N7O21P3S"
-      - charge: -4
-      - inchis: ""
     - !!omap
       - id: "MAM00036x"
       - name: "(24R,25R)3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA"
@@ -2622,7 +2608,7 @@
       - inchis: ""
     - !!omap
       - id: "MAM00185c"
-      - name: "[apocarboxlase]"
+      - name: "[apocarboxylase]"
       - compartment: "c"
       - formula: "XH"
       - charge: 0
@@ -6582,20 +6568,6 @@
       - formula: "C20H31O4"
       - charge: -1
       - inchis: ""
-    - !!omap
-      - id: "MAM00591c"
-      - name: "20-hydroxy-arachidonate"
-      - compartment: "c"
-      - formula: "C20H31O3"
-      - charge: -1
-      - inchis: ""
-    - !!omap
-      - id: "MAM00591e"
-      - name: "20-hydroxy-arachidonate"
-      - compartment: "e"
-      - formula: "C20H31O3"
-      - charge: -1
-      - inchis: ""
     - !!omap
       - id: "MAM00592r"
       - name: "20-hydroxycholesterol"
@@ -6869,13 +6841,6 @@
       - formula: "C48H76N7O21P3S"
       - charge: -4
       - inchis: ""
-    - !!omap
-      - id: "MAM00616m"
-      - name: "25(R)THCA-CoA"
-      - compartment: "m"
-      - formula: "C48H76N7O20P3S"
-      - charge: -4
-      - inchis: ""
     - !!omap
       - id: "MAM00616x"
       - name: "25(R)THCA-CoA"
@@ -6897,13 +6862,6 @@
       - formula: "C48H76N7O19P3S"
       - charge: -4
       - inchis: ""
-    - !!omap
-      - id: "MAM00618m"
-      - name: "25(S)THCA-CoA"
-      - compartment: "m"
-      - formula: "C48H76N7O20P3S"
-      - charge: -4
-      - inchis: ""
     - !!omap
       - id: "MAM00618x"
       - name: "25(S)THCA-CoA"
@@ -8283,13 +8241,6 @@
       - formula: "C27H46O5"
       - charge: 0
       - inchis: "InChI=1/C27H46O5/c1-15(6-9-22(30)25(2,3)32)18-7-8-19-24-20(14-23(31)27(18,19)5)26(4)11-10-17(28)12-16(26)13-21(24)29/h15-21,23-24,28-29,31-32H,6-14H2,1-5H3/t15?,16?,17?,18-,19?,20?,21?,23?,24?,26+,27-/s2"
-    - !!omap
-      - id: "MAM00748m"
-      - name: "3alpha,7alpha,12alpha-trihydroxy-5beta-24-oxocholestanoyl-CoA"
-      - compartment: "m"
-      - formula: "C48H74N7O21P3S"
-      - charge: -4
-      - inchis: ""
     - !!omap
       - id: "MAM00748x"
       - name: "3alpha,7alpha,12alpha-trihydroxy-5beta-24-oxocholestanoyl-CoA"
@@ -8297,13 +8248,6 @@
       - formula: "C48H74N7O21P3S"
       - charge: -4
       - inchis: ""
-    - !!omap
-      - id: "MAM00749m"
-      - name: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA"
-      - compartment: "m"
-      - formula: "C48H74N7O20P3S"
-      - charge: -4
-      - inchis: ""
     - !!omap
       - id: "MAM00749x"
       - name: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA"
@@ -8430,13 +8374,6 @@
       - formula: "C27H45O4"
       - charge: -1
       - inchis: ""
-    - !!omap
-      - id: "MAM00759c"
-      - name: "3alpha-hydroxy-5alpha-pregnan-20-one"
-      - compartment: "c"
-      - formula: "C21H34O2"
-      - charge: 0
-      - inchis: ""
     - !!omap
       - id: "MAM00760c"
       - name: "3-amino-propanal"
@@ -9802,13 +9739,6 @@
       - formula: "C45H68N7O18P3S"
       - charge: -4
       - inchis: ""
-    - !!omap
-      - id: "MAM00902c"
-      - name: "3-oxo-tetracosa-9,12,15,18,21-all-cis-pentaenoyl-CoA"
-      - compartment: "c"
-      - formula: "C45H66N7O18P3S"
-      - charge: -4
-      - inchis: ""
     - !!omap
       - id: "MAM00903c"
       - name: "3-oxo-tetracosa-9,12,15,18-all-cis-tetraenoyl-CoA"
@@ -13540,48 +13470,6 @@
       - formula: "S"
       - charge: -2
       - inchis: ""
-    - !!omap
-      - id: "MAM01268c"
-      - name: "activation-ppara"
-      - compartment: "c"
-      - formula: "C2303H3655N619O695S34R"
-      - charge: 0
-      - inchis: ""
-    - !!omap
-      - id: "MAM01268m"
-      - name: "activation-ppara"
-      - compartment: "m"
-      - formula: "C2303H3655N619O695S34R"
-      - charge: 0
-      - inchis: ""
-    - !!omap
-      - id: "MAM01268n"
-      - name: "activation-ppara"
-      - compartment: "n"
-      - formula: "C2303H3655N619O695S34R"
-      - charge: 0
-      - inchis: ""
-    - !!omap
-      - id: "MAM01268x"
-      - name: "activation-ppara"
-      - compartment: "x"
-      - formula: "C2303H3655N619O695S34R"
-      - charge: 0
-      - inchis: ""
-    - !!omap
-      - id: "MAM01268r"
-      - name: "activation-ppara"
-      - compartment: "r"
-      - formula: "C2303H3655N619O695S34R"
-      - charge: 0
-      - inchis: ""
-    - !!omap
-      - id: "MAM01268e"
-      - name: "activation-ppara"
-      - compartment: "e"
-      - formula: "C2303H3655N619O695S34R"
-      - charge: 0
-      - inchis: ""
     - !!omap
       - id: "MAM01269c"
       - name: "acyl-CoA-bile-PC pool"
@@ -15591,6 +15479,13 @@
       - formula: "C17H26N4O5SX"
       - charge: -1
       - inchis: ""
+    - !!omap
+      - id: "MAM01422m"
+      - name: "carboxybiotin-carboxyl-carrier"
+      - compartment: "m"
+      - formula: "C17H26N4O5SX"
+      - charge: -1
+      - inchis: ""
     - !!omap
       - id: "MAM01423c"
       - name: "carnosine"
@@ -16921,13 +16816,6 @@
       - formula: "C45H70N7O20P3S"
       - charge: -4
       - inchis: ""
-    - !!omap
-      - id: "MAM01514m"
-      - name: "choloyl-CoA"
-      - compartment: "m"
-      - formula: "C45H70N7O20P3S"
-      - charge: -4
-      - inchis: ""
     - !!omap
       - id: "MAM01514x"
       - name: "choloyl-CoA"
@@ -21219,13 +21107,6 @@
       - formula: "CO2R"
       - charge: -1
       - inchis: ""
-    - !!omap
-      - id: "MAM01816n"
-      - name: "fatty acid-ligands"
-      - compartment: "n"
-      - formula: "R"
-      - charge: 0
-      - inchis: ""
     - !!omap
       - id: "MAM01819e"
       - name: "fatty acid-uptake pool"
@@ -32244,27 +32125,6 @@
       - formula: "C10H13N2O4"
       - charge: -1
       - inchis: ""
-    - !!omap
-      - id: "MAM02757c"
-      - name: "PPARA"
-      - compartment: "c"
-      - formula: "C2303H3655N619O695S34"
-      - charge: 0
-      - inchis: ""
-    - !!omap
-      - id: "MAM02757l"
-      - name: "PPARA"
-      - compartment: "l"
-      - formula: "C2303H3655N619O695S34"
-      - charge: 0
-      - inchis: ""
-    - !!omap
-      - id: "MAM02757n"
-      - name: "PPARA"
-      - compartment: "n"
-      - formula: "C2303H3655N619O695S34"
-      - charge: 0
-      - inchis: ""
     - !!omap
       - id: "MAM02759c"
       - name: "PPi"
@@ -37284,13 +37144,6 @@
       - formula: "C6H10O5"
       - charge: 0
       - inchis: ""
-    - !!omap
-      - id: "MAM03162c"
-      - name: "5,6-dihydroxyindole"
-      - compartment: "c"
-      - formula: "C8H7NO2"
-      - charge: 0
-      - inchis: ""
     - !!omap
       - id: "MAM03163c"
       - name: "indole-5,6-quinone"
@@ -37382,13 +37235,6 @@
       - formula: "C9H9O4"
       - charge: -1
       - inchis: ""
-    - !!omap
-      - id: "MAM03226m"
-      - name: "(S)-3-Hydroxyisobutyryl Coenzyme A"
-      - compartment: "m"
-      - formula: "C25H38N7O18P3S"
-      - charge: -4
-      - inchis: ""
     - !!omap
       - id: "MAM00799c"
       - name: "3-hydroxypropionyl-CoA"
@@ -37566,7 +37412,7 @@
       - inchis: ""
     - !!omap
       - id: "MAM00185m"
-      - name: "[apocarboxlase]"
+      - name: "[apocarboxylase]"
       - compartment: "m"
       - formula: "XH"
       - charge: 0
@@ -37935,13 +37781,6 @@
       - formula: "C30H48N7O17P3S"
       - charge: -4
       - inchis: ""
-    - !!omap
-      - id: "MAM03554c"
-      - name: "4,8-Dimethylnonanoyl Coenzyme A"
-      - compartment: "c"
-      - formula: "C32H52N7O17P3S"
-      - charge: -4
-      - inchis: ""
     - !!omap
       - id: "MAM03554m"
       - name: "4,8-Dimethylnonanoyl Coenzyme A"
@@ -38089,13 +37928,6 @@
       - formula: "C8H12O10PR2"
       - charge: -1
       - inchis: ""
-    - !!omap
-      - id: "MAM03884e"
-      - name: "Phytanate"
-      - compartment: "e"
-      - formula: "C20H39O2"
-      - charge: -1
-      - inchis: ""
     - !!omap
       - id: "MAM02808e"
       - name: "PS-LD pool"
@@ -38166,13 +37998,6 @@
       - formula: "C40H68N7O17P3S"
       - charge: -4
       - inchis: ""
-    - !!omap
-      - id: "MAM03884c"
-      - name: "Phytanate"
-      - compartment: "c"
-      - formula: "C20H39O2"
-      - charge: -1
-      - inchis: ""
     - !!omap
       - id: "MAM03791m"
       - name: "11-Octadecenoyl Coenzyme A"
@@ -38859,20 +38684,6 @@
       - formula: "C48H74N7O19P3S"
       - charge: -4
       - inchis: ""
-    - !!omap
-      - id: "MAM03318r"
-      - name: "Chenodeoxycholate"
-      - compartment: "r"
-      - formula: "C24H39O4"
-      - charge: -1
-      - inchis: ""
-    - !!omap
-      - id: "MAM03318c"
-      - name: "Chenodeoxycholate"
-      - compartment: "c"
-      - formula: "C24H39O4"
-      - charge: -1
-      - inchis: ""
     - !!omap
       - id: "MAM00726m"
       - name: "3,4-dihydroxymandelaldehyde"
@@ -38922,13 +38733,6 @@
       - formula: "C30H50O"
       - charge: 0
       - inchis: "InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1"
-    - !!omap
-      - id: "MAM03318e"
-      - name: "Chenodeoxycholate"
-      - compartment: "e"
-      - formula: "C24H39O4"
-      - charge: -1
-      - inchis: ""
     - !!omap
       - id: "MAM00755m"
       - name: "3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA"
@@ -40504,13 +40308,6 @@
       - formula: "C23H34O3"
       - charge: 0
       - inchis: "InChI=1S/C23H34O3/c1-15(10-12-24)20-8-9-21-17(5-4-11-23(20,21)3)6-7-18-13-19(25)14-22(26)16(18)2/h6-7,12,15,19-22,25-26H,2,4-5,8-11,13-14H2,1,3H3/b17-6+,18-7-/t15-,19+,20-,21+,22+,23?/m0/s1"
-    - !!omap
-      - id: "MAM03354c"
-      - name: "Tetracosa-9,12,15,18-All-Cis-Tetraenoyl Coenzyme A"
-      - compartment: "c"
-      - formula: "C45H70N7O17P3S"
-      - charge: -4
-      - inchis: ""
     - !!omap
       - id: "MAM00681r"
       - name: "2-trans-9,12,15,18-all-cis-tetracosapentaenoyl-CoA"
@@ -40518,13 +40315,6 @@
       - formula: "C45H68N7O17P3S"
       - charge: -4
       - inchis: ""
-    - !!omap
-      - id: "MAM03354r"
-      - name: "Tetracosa-9,12,15,18-All-Cis-Tetraenoyl Coenzyme A"
-      - compartment: "r"
-      - formula: "C45H70N7O17P3S"
-      - charge: -4
-      - inchis: ""
     - !!omap
       - id: "MAM00864r"
       - name: "3-oxo-docosa-7,10,13,16-all-cis-tetraenoyl-CoA"
@@ -40749,13 +40539,6 @@
       - formula: "C39H62N7O17P3S"
       - charge: -4
       - inchis: ""
-    - !!omap
-      - id: "MAM03367m"
-      - name: "24(R),25(R)-Varanoyl Coenzyme A"
-      - compartment: "m"
-      - formula: "C48H76N7O21P3S"
-      - charge: -4
-      - inchis: ""
     - !!omap
       - id: "MAM03367x"
       - name: "24(R),25(R)-Varanoyl Coenzyme A"
@@ -40777,20 +40560,6 @@
       - formula: "C48H74N7O21P3S"
       - charge: -4
       - inchis: ""
-    - !!omap
-      - id: "MAM03368m"
-      - name: "24-Oxo-25(R)-Trihydroxycoprostanoyl Coenzyme A"
-      - compartment: "m"
-      - formula: "C48H74N7O21P3S"
-      - charge: -4
-      - inchis: ""
-    - !!omap
-      - id: "MAM03368x"
-      - name: "24-Oxo-25(R)-Trihydroxycoprostanoyl Coenzyme A"
-      - compartment: "x"
-      - formula: "C48H74N7O21P3S"
-      - charge: -4
-      - inchis: ""
     - !!omap
       - id: "MAM01428e"
       - name: "CDP-ethanolamine"
@@ -40980,13 +40749,6 @@
       - formula: "C20H31O4"
       - charge: -1
       - inchis: ""
-    - !!omap
-      - id: "MAM03325c"
-      - name: "3-(Methylthio)Propionate"
-      - compartment: "c"
-      - formula: "C4H7O2S"
-      - charge: -1
-      - inchis: ""
     - !!omap
       - id: "MAM03510c"
       - name: "Methanethiol"
@@ -41155,13 +40917,6 @@
       - formula: "C41H59N7O22P3S"
       - charge: -5
       - inchis: ""
-    - !!omap
-      - id: "MAM03332c"
-      - name: "(8Z,11Z,14Z)-Eicosatrienoic Acid"
-      - compartment: "c"
-      - formula: "C20H33O2"
-      - charge: -1
-      - inchis: ""
     - !!omap
       - id: "MAM02785n"
       - name: "prostaglandin E1"
@@ -41617,13 +41372,6 @@
       - formula: "C17H33NO5"
       - charge: 0
       - inchis: "InChI=1/C17H33NO5/c1-5-6-7-8-9-10-14(19)13-17(22)23-15(18(2,3)4)11-12-16(20)21/h14-15,19H,5-13H2,1-4H3"
-    - !!omap
-      - id: "MAM03540c"
-      - name: "Lauroyl Carnitine"
-      - compartment: "c"
-      - formula: "C19H37NO4"
-      - charge: 0
-      - inchis: "InChI=1S/C19H37NO4/c1-5-6-7-8-9-10-11-12-13-14-19(23)24-17(15-18(21)22)16-20(2,3)4/h17H,5-16H2,1-4H3/t17-/m1/s1"
     - !!omap
       - id: "MAM00042c"
       - name: "(2E)-dodecenoyl-CoA"
@@ -42079,13 +41827,6 @@
       - formula: "C19H37NO5"
       - charge: 0
       - inchis: "InChI=1/C19H37NO5/c1-5-6-7-8-9-10-11-12-16(21)13-19(24)25-17(14-18(22)23)15-20(2,3)4/h16-17,21H,5-15H2,1-4H3"
-    - !!omap
-      - id: "MAM03540e"
-      - name: "Lauroyl Carnitine"
-      - compartment: "e"
-      - formula: "C19H37NO4"
-      - charge: 0
-      - inchis: "InChI=1S/C19H37NO4/c1-5-6-7-8-9-10-11-12-13-14-19(23)24-17(15-18(21)22)16-20(2,3)4/h17H,5-16H2,1-4H3/t17-/m1/s1"
     - !!omap
       - id: "MAM03541e"
       - name: "Dodecenoyl Carnitine"
@@ -45208,13 +44949,6 @@
       - formula: "C20H31O4"
       - charge: 0
       - inchis: ""
-    - !!omap
-      - id: "MAM03332e"
-      - name: "(8Z,11Z,14Z)-Eicosatrienoic Acid"
-      - compartment: "e"
-      - formula: "C20H33O2"
-      - charge: -1
-      - inchis: ""
     - !!omap
       - id: "MAM00378e"
       - name: "15(S)-HETrE"
@@ -45957,13 +45691,6 @@
       - formula: "C9H9O3"
       - charge: -1
       - inchis: ""
-    - !!omap
-      - id: "MAM03231c"
-      - name: "3-Hydroxyphenylpropionic Acid (3-Hppa)"
-      - compartment: "c"
-      - formula: "C9H9O3"
-      - charge: -1
-      - inchis: ""
     - !!omap
       - id: "MAM02622e"
       - name: "normetanephrine"
@@ -56870,6 +56597,20 @@
       - formula: "C57H85O3"
       - charge: -1
       - inchis: ""
+    - !!omap
+      - id: "MAM01729e"
+      - name: "dodecanoylcarnitine"
+      - compartment: "e"
+      - formula: "C19H37NO4"
+      - charge: 0
+      - inchis: ""
+    - !!omap
+      - id: "MAM00853c"
+      - name: "3-oxo-all-cis-6,9,12,15,18-tetracosapentaenoyl-CoA"
+      - compartment: "c"
+      - formula: "C45H66N7O18P3S"
+      - charge: -4
+      - inchis: ""
     - !!omap
       - id: "MAM15003c"
       - name: "L-Allothreonine"
@@ -57123,12 +56864,12 @@
       - charge: 0
       - inchis: "InChI=1S/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23+,24?,27-,28+/m1/s1"
     - !!omap
-      - id: "MAM01066r"
-      - name: "5alpha-cholesta-7,24-dien-3beta-ol"
+      - id: "MAM01449r"
+      - name: "cholestenol"
       - compartment: "r"
-      - formula: "C27H44O"
+      - formula: "C27H46O"
       - charge: 0
-      - inchis: "InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1"
+      - inchis: "InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1"
     - !!omap
       - id: "MAM02932r"
       - name: "squalene 2,3-oxide"
@@ -57822,7 +57563,7 @@
           - MAM03108c: -3
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "GlyS or Gyg"
+      - gene_reaction_rule: "Glys or Gyg"
       - rxnNotes: ""
       - eccodes: "2.4.1.11"
       - references: "PMID:12133002;PMID:4475632;PMID:5810070"
@@ -57839,7 +57580,7 @@
           - MAM03161c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "Gbs-70E or GlyS"
+      - gene_reaction_rule: "Gbs-70E or Glys"
       - rxnNotes: ""
       - eccodes: "2.4.1.11"
       - references: ""
@@ -57871,7 +57612,7 @@
           - MAM02751c: -3
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "GlyP"
+      - gene_reaction_rule: "Glyp"
       - rxnNotes: ""
       - eccodes: "2.4.1.1"
       - references: "PMID:12133002;PMID:4475632;PMID:5810070"
@@ -57920,7 +57661,7 @@
           - MAM02751c: -7
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "GlyP"
+      - gene_reaction_rule: "Glyp"
       - rxnNotes: ""
       - eccodes: "2.4.1.1"
       - references: "PMID:12133002;PMID:4475632;PMID:5810070"
@@ -59729,8 +59470,8 @@
       - upper_bound: 1000
       - gene_reaction_rule: "Arc42 or CG3902 or Egm or Mcad"
       - rxnNotes: ""
-      - eccodes: "1.3.99.3"
-      - references: ""
+      - eccodes: "1.3.99.3;1.3.8.7"
+      - references: "PMID:10502673;PMID:3597357;PMID:4062874"
       - subsystem:
           - "Propanoate metabolism"
       - confidence_score: 0
@@ -59765,7 +59506,7 @@
           - MAM02774m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG17691 and CG7430 and CG8199 and Dbct"
+      - gene_reaction_rule: "BckdhA and BckdhB and CG7430 and Dbct"
       - rxnNotes: ""
       - eccodes: "1.2.7.2"
       - references: "PMID:2649080;PMID:283398;PMID:3718468;PMID:9381974"
@@ -60647,7 +60388,7 @@
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "AdSS"
+      - gene_reaction_rule: "Adss"
       - rxnNotes: ""
       - eccodes: "6.3.4.4"
       - references: "PMID:1592113"
@@ -60843,7 +60584,7 @@
           - MAM01862c: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "AdSL or gw"
+      - gene_reaction_rule: "Adsl or gw"
       - rxnNotes: ""
       - eccodes: "4.3.2.2"
       - references: "PMID:1872474"
@@ -61286,7 +61027,7 @@
           - MAM02990c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx-2)"
+      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx2)"
       - rxnNotes: ""
       - eccodes: "1.17.4.1"
       - references: "PMID:6121703;PMID:8074691"
@@ -61304,7 +61045,7 @@
           - MAM02990c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx-2)"
+      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx2)"
       - rxnNotes: ""
       - eccodes: "1.17.4.1"
       - references: "PMID:6121703;PMID:8074691"
@@ -61322,7 +61063,7 @@
           - MAM02990c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx-2)"
+      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx2)"
       - rxnNotes: ""
       - eccodes: "1.17.4.1"
       - references: "PMID:6121703;PMID:8074691"
@@ -61340,7 +61081,7 @@
           - MAM02990c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx-2)"
+      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx2)"
       - rxnNotes: ""
       - eccodes: "1.17.4.1"
       - references: "PMID:6121703;PMID:8074691"
@@ -61358,7 +61099,7 @@
           - MAM02990c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx-2)"
+      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx2)"
       - rxnNotes: ""
       - eccodes: "1.17.4.1"
       - references: "PMID:6121703;PMID:8074691"
@@ -61376,7 +61117,7 @@
           - MAM03130c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx-2)"
+      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx2)"
       - rxnNotes: ""
       - eccodes: "1.17.4.1"
       - references: "PMID:6121703;PMID:8074691"
@@ -61394,7 +61135,7 @@
           - MAM02990c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx-2)"
+      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx2)"
       - rxnNotes: ""
       - eccodes: "1.17.4.1"
       - references: "PMID:6121703;PMID:8074691"
@@ -61412,7 +61153,7 @@
           - MAM03106c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx-2)"
+      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx2)"
       - rxnNotes: ""
       - eccodes: "1.17.4.1"
       - references: "PMID:6121703;PMID:8074691"
@@ -61496,9 +61237,9 @@
       - id: "MAR04650"
       - name: "Xanthine:oxygen oxidoreductase"
       - metabolites: !!omap
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
           - MAM03120x: 1
           - MAM03148x: -1
       - lower_bound: 0
@@ -61719,7 +61460,7 @@
           - MAM02872c: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "AdSL or gw"
+      - gene_reaction_rule: "Adsl or gw"
       - rxnNotes: ""
       - eccodes: "4.3.2.2"
       - references: "PMID:1872474"
@@ -61939,10 +61680,10 @@
       - id: "MAR08755"
       - name: "Hypoxanthine:oxygen oxidoreductase"
       - metabolites: !!omap
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02159x: -1
-          - MAM02630x: -1
           - MAM03148x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -62276,24 +62017,6 @@
       - subsystem:
           - "Pyrimidine metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03931"
-      - name: "NADPH:oxidized-thioredoxin oxidoreductase"
-      - metabolites: !!omap
-          - MAM02039c: -1
-          - MAM02554c: 1
-          - MAM02555c: -1
-          - MAM02666c: -1
-          - MAM02990c: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Trxr1 or Trxr2"
-      - rxnNotes: ""
-      - eccodes: "1.8.1.9"
-      - references: "PMID:10462449;PMID:11060283;PMID:15110392"
-      - subsystem:
-          - "Pyrimidine metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03969"
       - name: ""
@@ -62982,7 +62705,7 @@
       - gene_reaction_rule: "pyd3"
       - rxnNotes: ""
       - eccodes: "3.5.1.6"
-      - references: "PMID:10542323;PMID:3678231"
+      - references: "PMID:10542323;PMID:3678231;PMID:11508704;PMID:5773299"
       - subsystem:
           - "Pyrimidine metabolism"
       - confidence_score: 0
@@ -63033,7 +62756,7 @@
           - MAM02487m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx-2)"
+      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx2)"
       - rxnNotes: ""
       - eccodes: "1.17.4.1"
       - references: "PMID:5553404;PMID:5671058"
@@ -63051,7 +62774,7 @@
           - MAM02487m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx-2)"
+      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx2)"
       - rxnNotes: ""
       - eccodes: "1.17.4.1"
       - references: "PMID:5553404;PMID:5671058"
@@ -63121,7 +62844,7 @@
           - MAM03130m: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx-2)"
+      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx2)"
       - rxnNotes: ""
       - eccodes: "1.17.4.1"
       - references: "PMID:6997299;PMID:8483833"
@@ -63139,7 +62862,7 @@
           - MAM03130n: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx-2)"
+      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx2)"
       - rxnNotes: ""
       - eccodes: "1.17.4.1"
       - references: "PMID:6997299;PMID:8483833"
@@ -64884,7 +64607,7 @@
       - gene_reaction_rule: "Trxr1 or Trxr2"
       - rxnNotes: ""
       - eccodes: "1.8.1.9"
-      - references: ""
+      - references: "PMID:5553404;PMID:5671058"
       - subsystem:
           - "Nucleotide metabolism"
       - confidence_score: 0
@@ -65551,11 +65274,11 @@
       - name: "D-Aspartate:oxygen oxidoreductase (deaminating)"
       - metabolites: !!omap
           - MAM01641x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02578x: 1
-          - MAM02630x: -1
           - MAM02633x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -65740,24 +65463,6 @@
       - subsystem:
           - "Arginine and proline metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03838"
-      - name: ""
-      - metabolites: !!omap
-          - MAM00559m: -1
-          - MAM02039m: -1
-          - MAM02770m: 1
-          - MAM03102m: -1
-          - MAM03103m: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "slgA"
-      - rxnNotes: ""
-      - eccodes: "1.5.99.8"
-      - references: "PMID:18506409"
-      - subsystem:
-          - "Arginine and proline metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03895"
       - name: "ATP:L-glutamate 5-phosphotransferase"
@@ -66361,10 +66066,10 @@
       - name: "N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming)"
       - metabolites: !!omap
           - MAM01250x: 1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02504x: -1
-          - MAM02630x: -1
           - MAM02923x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -66417,10 +66122,10 @@
       - name: "N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming)"
       - metabolites: !!omap
           - MAM01250x: 1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02503x: -1
-          - MAM02630x: -1
           - MAM02812x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -66455,11 +66160,11 @@
       - name: ""
       - metabolites: !!omap
           - MAM01250x: 1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02501x: -1
           - MAM02503x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "CG8032"
@@ -66784,7 +66489,7 @@
       - gene_reaction_rule: "slgA"
       - rxnNotes: ""
       - eccodes: "1.5.99.8"
-      - references: ""
+      - references: "PMID:18506409"
       - subsystem:
           - "Arginine and proline metabolism"
       - confidence_score: 0
@@ -66871,10 +66576,10 @@
           - MAM02468m: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "CG3902"
+      - gene_reaction_rule: "Arc42 or CG3902"
       - rxnNotes: ""
-      - eccodes: "1.3.8.5"
-      - references: ""
+      - eccodes: "1.3.8.5;1.3.8.1;1.3.99.12"
+      - references: "PMID:12855692;PMID:6401712;PMID:6874697;PMID:3597357"
       - subsystem:
           - "Glycine, serine and threonine metabolism"
       - confidence_score: 0
@@ -66888,10 +66593,10 @@
           - MAM02189m: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "CG3902"
+      - gene_reaction_rule: "CG3902 or CG6638"
       - rxnNotes: ""
-      - eccodes: "1.3.8.5"
-      - references: ""
+      - eccodes: "1.3.8.4;1.3.8.5"
+      - references: "PMID:3597357;PMID:9214289"
       - subsystem:
           - "Glycine, serine and threonine metabolism"
       - confidence_score: 0
@@ -66959,10 +66664,10 @@
           - MAM02999m: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "CG3902"
+      - gene_reaction_rule: "Arc42 or CG3902"
       - rxnNotes: ""
-      - eccodes: "1.3.8.5"
-      - references: ""
+      - eccodes: "1.3.8.5;1.3.8.1;1.3.99.12"
+      - references: "PMID:6401712"
       - subsystem:
           - "Glycine, serine and threonine metabolism"
       - confidence_score: 0
@@ -67057,11 +66762,11 @@
       - id: "MAR03849"
       - name: "sarcosine:oxygen oxidoreductase (demethylating)"
       - metabolites: !!omap
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM01831x: 1
           - MAM01986x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
           - MAM02880x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -67409,13 +67114,13 @@
       - id: "MAR04789"
       - name: "glycine:oxygen oxidoreductase (deaminating)"
       - metabolites: !!omap
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM01986x: -1
           - MAM02007x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02578x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Daao1"
@@ -67742,7 +67447,7 @@
           - MAM02867c: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "CG33054 or Ntan1 or Sirt1 or Sirt2 or Sirt6 or Sirt7 or tun"
+      - gene_reaction_rule: "Ntan1 or Sirt1 or Sirt2 or Sirt6 or Sirt7 or Targ1 or tun"
       - rxnNotes: ""
       - eccodes: "3.5.1.-"
       - references: ""
@@ -67793,7 +67498,7 @@
           - MAM02867c: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "CG33054 or Ntan1 or Sirt1 or Sirt2 or Sirt6 or Sirt7 or tun"
+      - gene_reaction_rule: "Ntan1 or Sirt1 or Sirt2 or Sirt6 or Sirt7 or Targ1 or tun"
       - rxnNotes: ""
       - eccodes: "3.5.1.-"
       - references: "PMID:11669511;PMID:8898873"
@@ -67810,7 +67515,7 @@
           - MAM02867c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG33054 or Ntan1 or Sirt1 or Sirt2 or Sirt6 or Sirt7 or tun"
+      - gene_reaction_rule: "Ntan1 or Sirt1 or Sirt2 or Sirt6 or Sirt7 or Targ1 or tun"
       - rxnNotes: ""
       - eccodes: "3.5.1.-"
       - references: "PMID:11669511"
@@ -67977,7 +67682,7 @@
           - MAM02868m: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "LKRSDH or Sccpdh1 or Sccpdh2"
+      - gene_reaction_rule: "CG2604 or CG5167 or LKRSDH"
       - rxnNotes: ""
       - eccodes: "1.5.1.9"
       - references: "PMID:235294;PMID:4774398"
@@ -68280,12 +67985,12 @@
       - name: "L-lysine:oxygen 2-oxidoreductase (deaminating)"
       - metabolites: !!omap
           - MAM01157x: 1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02426x: -1
           - MAM02578x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -68923,23 +68628,6 @@
       - subsystem:
           - "Tyrosine metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR09733"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01596c: 1
-          - MAM02039c: -1
-          - MAM02355c: -1
-          - MAM03162c: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Tyrosine metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03206"
       - name: "acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase"
@@ -68957,23 +68645,6 @@
       - subsystem:
           - "Valine, leucine, and isoleucine metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03211"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01265m: 1
-          - MAM02774m: -1
-          - MAM03102m: 1
-          - MAM03103m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Mcad"
-      - rxnNotes: ""
-      - eccodes: "1.3.8.7"
-      - references: "PMID:10502673;PMID:3597357;PMID:4062874"
-      - subsystem:
-          - "Valine, leucine, and isoleucine metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03747"
       - name: "L-Valine:2-oxoglutarate aminotransferase"
@@ -69145,7 +68816,7 @@
           - MAM02856m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG17691 and CG8199"
+      - gene_reaction_rule: "BckdhA and BckdhB"
       - rxnNotes: ""
       - eccodes: "1.2.4.4"
       - references: "PMID:11839747;PMID:12387880;PMID:15576032"
@@ -69180,7 +68851,7 @@
           - MAM02858m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG17691 and CG8199"
+      - gene_reaction_rule: "BckdhA and BckdhB"
       - rxnNotes: ""
       - eccodes: "1.2.4.4"
       - references: "PMID:11839747;PMID:12387880;PMID:15576032"
@@ -69476,25 +69147,6 @@
       - subsystem:
           - "Phenylalanine, tyrosine and tryptophan biosynthesis"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR04242"
-      - name: "glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating)"
-      - metabolites: !!omap
-          - MAM01596m: 1
-          - MAM01622m: 1
-          - MAM01977m: -1
-          - MAM02039m: -1
-          - MAM03102m: 1
-          - MAM03103m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "CG9547"
-      - rxnNotes: ""
-      - eccodes: "1.3.8.6"
-      - references: "PMID:3081514"
-      - subsystem:
-          - "Phenylalanine, tyrosine and tryptophan biosynthesis"
-      - confidence_score: 0
     - !!omap
       - id: "MAR04243"
       - name: "glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating)"
@@ -69510,7 +69162,7 @@
       - gene_reaction_rule: "CG9547"
       - rxnNotes: ""
       - eccodes: "1.3.8.6"
-      - references: ""
+      - references: "PMID:3081514"
       - subsystem:
           - "Phenylalanine, tyrosine and tryptophan biosynthesis"
       - confidence_score: 0
@@ -72336,11 +71988,11 @@
       - name: "D-alanine:oxygen oxidoreductase (deaminating)"
       - metabolites: !!omap
           - MAM01638x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02578x: 1
-          - MAM02630x: -1
           - MAM02819x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -72375,11 +72027,11 @@
       - metabolites: !!omap
           - MAM01101x: 1
           - MAM01640x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02578x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Daao1"
@@ -72395,11 +72047,11 @@
       - metabolites: !!omap
           - MAM01073x: 1
           - MAM01740x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02578x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Daao1"
@@ -72421,30 +72073,13 @@
           - MAM02553m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG17691 and CG8199"
+      - gene_reaction_rule: "BckdhA and BckdhB"
       - rxnNotes: ""
       - eccodes: "1.2.1.25"
       - references: ""
       - subsystem:
           - "Valine, leucine, and isoleucine metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03751"
-      - name: ""
-      - metabolites: !!omap
-          - MAM02180m: -1
-          - MAM02468m: 1
-          - MAM03102m: 1
-          - MAM03103m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Arc42 or CG3902"
-      - rxnNotes: ""
-      - eccodes: "1.3.8.1;1.3.99.12"
-      - references: "PMID:12855692;PMID:6401712;PMID:6874697;PMID:3597357"
-      - subsystem:
-          - "Valine, leucine, and isoleucine metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03753"
       - name: "(S)-3-Hydroxyisobutyryl-CoA hydro-lyase"
@@ -72475,7 +72110,7 @@
       - gene_reaction_rule: "Hibch"
       - rxnNotes: ""
       - eccodes: "3.1.2.4"
-      - references: "PMID:11580916;PMID:8188708"
+      - references: "PMID:11580916;PMID:8188708;PMID:8824301"
       - subsystem:
           - "Valine, leucine, and isoleucine metabolism"
       - confidence_score: 0
@@ -72516,42 +72151,6 @@
       - subsystem:
           - "Valine, leucine, and isoleucine metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03767"
-      - name: "4-methyl-2-oxopentanoate:NAD+ oxidoreductase (CoA-mehtylpropanoylating)"
-      - metabolites: !!omap
-          - MAM01013m: -1
-          - MAM01596m: 1
-          - MAM01597m: -1
-          - MAM02189m: 1
-          - MAM02552m: -1
-          - MAM02553m: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "CG17691 and CG8199"
-      - rxnNotes: ""
-      - eccodes: "1.2.1.25"
-      - references: ""
-      - subsystem:
-          - "Valine, leucine, and isoleucine metabolism"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR03769"
-      - name: "3-methylbutanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase"
-      - metabolites: !!omap
-          - MAM00826m: -1
-          - MAM02189m: 1
-          - MAM03102m: -1
-          - MAM03103m: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "CG6638"
-      - rxnNotes: ""
-      - eccodes: "1.3.8.4"
-      - references: "PMID:3597357;PMID:9214289"
-      - subsystem:
-          - "Valine, leucine, and isoleucine metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03773"
       - name: "3-Methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)"
@@ -72600,30 +72199,13 @@
           - MAM02553m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG17691 and CG8199"
+      - gene_reaction_rule: "BckdhA and BckdhB"
       - rxnNotes: ""
       - eccodes: "1.2.1.25"
       - references: ""
       - subsystem:
           - "Valine, leucine, and isoleucine metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03783"
-      - name: "(S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase"
-      - metabolites: !!omap
-          - MAM00663m: -1
-          - MAM02999m: 1
-          - MAM03102m: 1
-          - MAM03103m: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "Arc42 or CG3902"
-      - rxnNotes: ""
-      - eccodes: "1.3.8.1;1.3.99.12"
-      - references: "PMID:6401712"
-      - subsystem:
-          - "Valine, leucine, and isoleucine metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03785"
       - name: "(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA hydro-liase"
@@ -72723,7 +72305,7 @@
           - MAM02857m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG17691 and CG8199"
+      - gene_reaction_rule: "BckdhA and BckdhB"
       - rxnNotes: ""
       - eccodes: "1.2.4.4"
       - references: "PMID:11839747;PMID:12387880;PMID:15576032"
@@ -76041,63 +75623,6 @@
       - subsystem:
           - "Protein assembly"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR05173"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01285c: 1404
-          - MAM01371c: -1404
-          - MAM02006c: -28
-          - MAM02039c: 1863
-          - MAM02040c: -1405
-          - MAM02335c: -31
-          - MAM02340c: -19
-          - MAM02341c: -19
-          - MAM02342c: -27
-          - MAM02351c: -19
-          - MAM02376c: -16
-          - MAM02377c: -34
-          - MAM02380c: -13
-          - MAM02401c: -29
-          - MAM02404c: -47
-          - MAM02405c: -33
-          - MAM02408c: -15
-          - MAM02412c: -22
-          - MAM02415c: -20
-          - MAM02416c: -37
-          - MAM02419c: -18
-          - MAM02421c: -14
-          - MAM02423c: -27
-          - MAM02751c: 1404
-          - MAM02757c: 1
-          - MAM03063c: 31
-          - MAM03064c: 19
-          - MAM03065c: 19
-          - MAM03066c: 27
-          - MAM03067c: 19
-          - MAM03068c: 16
-          - MAM03069c: 34
-          - MAM03070c: 28
-          - MAM03071c: 13
-          - MAM03072c: 29
-          - MAM03073c: 47
-          - MAM03074c: 33
-          - MAM03075c: 15
-          - MAM03076c: 22
-          - MAM03077c: 20
-          - MAM03078c: 37
-          - MAM03079c: 18
-          - MAM03081c: 14
-          - MAM03082c: 27
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Protein assembly"
-      - confidence_score: 0
     - !!omap
       - id: "MAR05174"
       - name: ""
@@ -77399,44 +76924,6 @@
       - subsystem:
           - "Protein degradation"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR05289"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01285l: 467
-          - MAM01307l: 31
-          - MAM01365l: 19
-          - MAM01369l: 19
-          - MAM01370l: 27
-          - MAM01371l: -467
-          - MAM01628l: 19
-          - MAM01974l: 34
-          - MAM01975l: 16
-          - MAM01986l: 28
-          - MAM02039l: 476
-          - MAM02040l: -934
-          - MAM02125l: 13
-          - MAM02184l: 29
-          - MAM02360l: 47
-          - MAM02426l: 33
-          - MAM02471l: 15
-          - MAM02724l: 22
-          - MAM02751l: 467
-          - MAM02757l: -1
-          - MAM02770l: 20
-          - MAM02896l: 37
-          - MAM02993l: 18
-          - MAM03101l: 14
-          - MAM03135l: 27
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Bace or CG11459 or Cp1 or CtsB or CtsF or cathD"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Protein degradation"
-      - confidence_score: 0
     - !!omap
       - id: "MAR05290"
       - name: ""
@@ -77987,16 +77474,16 @@
       - id: "MAR04145"
       - name: "acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)"
       - metabolites: !!omap
-          - MAM01261m: 1
-          - MAM01587m: -1
-          - MAM01597m: -1
-          - MAM02039m: -1
-          - MAM02040m: 1
-          - MAM02633m: 1
-      - lower_bound: -1000
+          - MAM01261m: -1
+          - MAM01587m: 1
+          - MAM01597m: 1
+          - MAM02039m: 1
+          - MAM02040m: -1
+          - MAM02633m: -1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "kdn"
-      - rxnNotes: ""
+      - rxnNotes: "Essentials of Medical Biochemistry: With Clinical Cases (2011) page 130, ISBN:978008091688"
       - eccodes: "2.3.3.1;2.3.3.3"
       - references: "PMID:12549038"
       - subsystem:
@@ -78230,11 +77717,11 @@
       - id: "MAR07704"
       - name: "Glyoxylate:oxygen oxidoreductase"
       - metabolites: !!omap
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02007x: -1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
           - MAM02661x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -78249,10 +77736,10 @@
       - id: "MAR07706"
       - name: "glycolate:oxygen 2-oxidoreductase"
       - metabolites: !!omap
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM01998x: -1
           - MAM02007x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Hao"
@@ -78262,23 +77749,6 @@
       - subsystem:
           - "Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR08743"
-      - name: "succinate:FAD oxidoreductase"
-      - metabolites: !!omap
-          - MAM01802m: 1
-          - MAM01803m: -1
-          - MAM01862m: -1
-          - MAM02943m: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "SdhA and SdhB and SdhC and SdhD"
-      - rxnNotes: ""
-      - eccodes: "1.3.5.1"
-      - references: ""
-      - subsystem:
-          - "Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR08772"
       - name: ""
@@ -78754,9 +78224,9 @@
       - id: "MAR08415"
       - name: "superoxide:superoxide oxidoreductase"
       - metabolites: !!omap
+          - MAM01802x: 1
+          - MAM01803x: 1
           - MAM02039x: -2
-          - MAM02041x: 1
-          - MAM02630x: 1
           - MAM02631x: -2
       - lower_bound: 0
       - upper_bound: 1000
@@ -81316,7 +80786,7 @@
           - MAM02130c: 1
           - MAM02554c: 1
           - MAM02555c: -1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: "FASN2"
       - rxnNotes: ""
@@ -81430,37 +80900,14 @@
       - subsystem:
           - "Fatty acid biosynthesis (even-chain)"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR04156"
-      - name: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)"
-      - metabolites: !!omap
-          - MAM01261c: -1
-          - MAM01285c: 1
-          - MAM01371c: -1
-          - MAM02039c: 1
-          - MAM02046c: -1
-          - MAM02444c: 1
-          - MAM02751c: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACC"
-      - rxnNotes: ""
-      - eccodes: "6.4.1.2"
-      - references: "PMID:7732023;PMID:16854592;PMID:18455495;PMID:10677481;PMID:16721829;PMID:17126822;PMID:235695;PMID:24055;PMID:6116153;PMID:6116159;PMID:6116163;PMID:6138355;PMID:7732023;PMID:9099716"
-      - subsystem:
-          - "Fatty acid biosynthesis (even-chain)"
-      - confidence_score: 0
     - !!omap
       - id: "MAR04295"
       - name: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)"
       - metabolites: !!omap
           - MAM01261m: -1
-          - MAM01285m: 1
-          - MAM01371m: -1
-          - MAM02039m: 1
-          - MAM02046m: -1
+          - MAM01357m: 1
+          - MAM01422m: -1
           - MAM02444m: 1
-          - MAM02751m: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACC"
@@ -84399,7 +83846,7 @@
       - name: ""
       - metabolites: !!omap
           - MAM00121c: -1
-          - MAM00902c: 1
+          - MAM00853c: 1
           - MAM01596c: 1
           - MAM01597c: 1
           - MAM02039c: -1
@@ -84418,7 +83865,7 @@
       - name: ""
       - metabolites: !!omap
           - MAM00718c: 1
-          - MAM00902c: -1
+          - MAM00853c: -1
           - MAM02039c: -1
           - MAM02554c: 1
           - MAM02555c: -1
@@ -84471,8 +83918,8 @@
       - metabolites: !!omap
           - MAM00113x: -1
           - MAM01664x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -85461,7 +84908,7 @@
       - gene_reaction_rule: "Sc2"
       - rxnNotes: ""
       - eccodes: "1.3.1.93"
-      - references: "PMID:10970790;PMID:10970790"
+      - references: "PMID:10970790;PMID:10970790;PMID:10970790"
       - subsystem:
           - "Omega-6 fatty acid metabolism"
       - confidence_score: 0
@@ -85490,8 +84937,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00110x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM03028x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -85821,7 +85268,7 @@
           - MAM03034m: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG4592 or CG4594 or CG4598 or Dci or Ech1"
+      - gene_reaction_rule: "CG4592 or CG4594 or CG4598 or CG9577 or Dci"
       - rxnNotes: ""
       - eccodes: "5.3.3.8;5.3.3.-"
       - references: "PMID:10407780;PMID:7775433"
@@ -85985,8 +85432,8 @@
       - metabolites: !!omap
           - MAM00682x: 1
           - MAM01364x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -86065,9 +85512,9 @@
       - name: ""
       - metabolites: !!omap
           - MAM00073x: 1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM01934x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -86134,8 +85581,8 @@
       - metabolites: !!omap
           - MAM00072x: 1
           - MAM00091x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -86235,7 +85682,7 @@
       - upper_bound: 1000
       - gene_reaction_rule: "Cyp18a1 or Cyp303a1 or Cyp305a1 or Cyp312a1 or Cyp4ad1 or Cyp9b2 or Cyp9c1 or Cyp9f2 or phtm"
       - rxnNotes: ""
-      - eccodes: "1.14.14.1"
+      - eccodes: "1.14.14.1;1.14.15.3"
       - references: ""
       - subsystem:
           - "Arachidonic acid metabolism"
@@ -88383,8 +87830,8 @@
       - metabolites: !!omap
           - MAM01119x: 1
           - MAM01120x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -88790,8 +88237,8 @@
       - metabolites: !!omap
           - MAM01121x: 1
           - MAM01122x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -89204,8 +88651,8 @@
       - metabolites: !!omap
           - MAM00026x: 1
           - MAM00582x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -89416,8 +88863,8 @@
       - metabolites: !!omap
           - MAM00258x: -1
           - MAM01037x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -89680,8 +89127,8 @@
       - metabolites: !!omap
           - MAM00027x: 1
           - MAM00587x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -89747,8 +89194,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00423x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02650x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -89832,9 +89279,9 @@
       - name: ""
       - metabolites: !!omap
           - MAM00015x: 1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: -3
-          - MAM02041x: 1
-          - MAM02630x: -1
           - MAM02652x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -90131,7 +89578,7 @@
       - gene_reaction_rule: "whd"
       - rxnNotes: ""
       - eccodes: "2.3.1.21"
-      - references: ""
+      - references: "PMID:12828998;PMID:9498103;PMID:3955080"
       - subsystem:
           - "Carnitine shuttle (cytosolic)"
       - confidence_score: 0
@@ -95369,7 +94816,7 @@
       - gene_reaction_rule: "Gpo1"
       - rxnNotes: ""
       - eccodes: "1.1.5.3"
-      - references: "PMID:7821823;PMID:8687421;PMID:8163052"
+      - references: "PMID:11955283;PMID:2115809;PMID:2923620;PMID:3338458;PMID:340460;PMID:8401296;PMID:8549872;PMID:8579375;PMID:9171333;PMID:9244403;PMID:9559543;PMID:7821823;PMID:8687421;PMID:8163052"
       - subsystem:
           - "Acylglycerides metabolism"
       - confidence_score: 0
@@ -95666,12 +95113,12 @@
           - MAM00317x: -1
           - MAM01261x: 12
           - MAM01597x: -11
+          - MAM01802x: -7
+          - MAM01803x: 7
           - MAM02039x: 11
           - MAM02040x: -11
-          - MAM02041x: 7
           - MAM02552x: -11
           - MAM02553x: 11
-          - MAM02630x: -7
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -95688,12 +95135,12 @@
           - MAM00134x: -1
           - MAM01261x: 12
           - MAM01597x: -11
+          - MAM01802x: -6
+          - MAM01803x: 6
           - MAM02039x: 11
           - MAM02040x: -11
-          - MAM02041x: 6
           - MAM02552x: -11
           - MAM02553x: 11
-          - MAM02630x: -6
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -95710,12 +95157,12 @@
           - MAM00131x: -1
           - MAM01261x: 12
           - MAM01597x: -11
+          - MAM01802x: -11
+          - MAM01803x: 11
           - MAM02039x: 3
           - MAM02040x: -11
-          - MAM02041x: 11
           - MAM02552x: -11
           - MAM02553x: 11
-          - MAM02630x: -11
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -95730,9 +95177,9 @@
       - name: ""
       - metabolites: !!omap
           - MAM00049x: 1
-          - MAM02041x: 1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02110x: -1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -95798,8 +95245,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00064x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02971x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -95867,8 +95314,8 @@
       - metabolites: !!omap
           - MAM00040x: 1
           - MAM01725x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -95935,8 +95382,8 @@
       - metabolites: !!omap
           - MAM00043x: 1
           - MAM01773x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -96002,8 +95449,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00057x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02941x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -96070,8 +95517,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00051x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02678x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -96138,9 +95585,9 @@
       - name: ""
       - metabolites: !!omap
           - MAM00066x: 1
-          - MAM02041x: 1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02495x: -1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -96206,9 +95653,9 @@
       - name: ""
       - metabolites: !!omap
           - MAM00042x: 1
-          - MAM02041x: 1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02345x: -1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -96275,8 +95722,8 @@
       - metabolites: !!omap
           - MAM00039x: 1
           - MAM01650x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -96342,8 +95789,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00059x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02644x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -96410,9 +95857,9 @@
       - name: ""
       - metabolites: !!omap
           - MAM00053x: 1
-          - MAM02041x: 1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02122x: -1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -96479,8 +95926,8 @@
       - metabolites: !!omap
           - MAM01412x: -1
           - MAM01622x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -96545,12 +95992,12 @@
       - metabolites: !!omap
           - MAM01261x: 10
           - MAM01597x: -10
+          - MAM01802x: -10
+          - MAM01803x: 10
           - MAM02039x: 10
           - MAM02040x: -10
-          - MAM02041x: 10
           - MAM02552x: -10
           - MAM02553x: 10
-          - MAM02630x: -10
           - MAM02774x: 1
           - MAM03047x: -1
       - lower_bound: 0
@@ -96566,9 +96013,9 @@
       - id: "MAR03326"
       - name: ""
       - metabolites: !!omap
-          - MAM02041x: 1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02112x: -1
-          - MAM02630x: -1
           - MAM03016x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -96635,8 +96082,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00025x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM03015x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -96703,8 +96150,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00016x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM03013x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -96771,8 +96218,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00007x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM03012x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -96838,8 +96285,8 @@
       - id: "MAR03342"
       - name: ""
       - metabolites: !!omap
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02647x: -1
           - MAM03025x: 1
       - lower_bound: 0
@@ -96907,8 +96354,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM01191x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM03019x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -96975,8 +96422,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM01141x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM03022x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -97053,23 +96500,6 @@
       - subsystem:
           - "Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03364"
-      - name: ""
-      - metabolites: !!omap
-          - MAM02041x: 1
-          - MAM02630x: -1
-          - MAM02677x: -1
-          - MAM03020x: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACOX1 or Acox3"
-      - rxnNotes: ""
-      - eccodes: "1.3.3.6"
-      - references: "PMID:1047780;PMID:8973539;PMID:11135616"
-      - subsystem:
-          - "Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03365"
       - name: ""
@@ -97121,23 +96551,6 @@
       - subsystem:
           - "Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03369"
-      - name: ""
-      - metabolites: !!omap
-          - MAM00118x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
-          - MAM03023x: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACOX1 or Acox3"
-      - rxnNotes: ""
-      - eccodes: "1.3.3.6"
-      - references: "PMID:1047780;PMID:8973539;PMID:11135616"
-      - subsystem:
-          - "Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03370"
       - name: ""
@@ -97270,8 +96683,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00078x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM03027x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -97339,8 +96752,8 @@
       - metabolites: !!omap
           - MAM00090x: 1
           - MAM00948x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -97422,8 +96835,8 @@
       - metabolites: !!omap
           - MAM00079x: 1
           - MAM00080x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
@@ -97492,30 +96905,13 @@
           - MAM00933x: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: ""
+      - gene_reaction_rule: "ScpX"
       - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
+      - eccodes: "1.5.1.10"
+      - references: "PMID:1703300"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03301"
-      - name: ""
-      - metabolites: !!omap
-          - MAM02041x: 1
-          - MAM02391x: -1
-          - MAM02630x: -1
-          - MAM03010x: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACOX1 or Acox3"
-      - rxnNotes: ""
-      - eccodes: "1.3.3.6"
-      - references: "PMID:8973539;PMID:10407780;PMID:11356167"
-      - subsystem:
-          - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03302"
       - name: ""
@@ -97567,23 +96963,6 @@
       - subsystem:
           - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03306"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01577x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
-          - MAM03009x: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACOX1 or Acox3"
-      - rxnNotes: ""
-      - eccodes: "1.3.3.6"
-      - references: "PMID:8973539;PMID:10407780;PMID:11356167"
-      - subsystem:
-          - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03307"
       - name: ""
@@ -97635,23 +97014,6 @@
       - subsystem:
           - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03311"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01576x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
-          - MAM03030x: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACOX1 or Acox3"
-      - rxnNotes: ""
-      - eccodes: "1.3.3.6"
-      - references: "PMID:8973539;PMID:10407780;PMID:11356167"
-      - subsystem:
-          - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03312"
       - name: ""
@@ -98016,8 +97378,8 @@
       - upper_bound: 1000
       - gene_reaction_rule: "Acadvl or Egm or Mcad"
       - rxnNotes: ""
-      - eccodes: "1.3.8.7;1.3.8.8;1.3.8.9;1.3.99.-"
-      - references: "PMID:13295225;PMID:1540149"
+      - eccodes: "1.3.8.7;1.3.8.8;1.3.8.9;1.3.99.-;1.3.99.3"
+      - references: "PMID:13295225;PMID:1540149;PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265"
       - subsystem:
           - "Beta oxidation of even-chain fatty acids (mitochondrial)"
       - confidence_score: 0
@@ -98082,10 +97444,10 @@
           - MAM02495m: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "Acadvl or Egm or Mcad"
+      - gene_reaction_rule: "ACOX1 or Acadvl or Acox3 or Egm or Mcad"
       - rxnNotes: ""
-      - eccodes: "1.3.8.7;1.3.8.8;1.3.8.9;1.3.99.-"
-      - references: "PMID:13295225;PMID:1540149"
+      - eccodes: "1.3.8.7;1.3.8.8;1.3.8.9;1.3.99.-;1.3.3.6"
+      - references: "PMID:13295225;PMID:1540149;PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265"
       - subsystem:
           - "Beta oxidation of even-chain fatty acids (mitochondrial)"
       - confidence_score: 0
@@ -98152,8 +97514,8 @@
       - upper_bound: 1000
       - gene_reaction_rule: "Acadvl or Egm or Mcad"
       - rxnNotes: ""
-      - eccodes: "1.3.8.7;1.3.8.8;1.3.8.9;1.3.99.-"
-      - references: "PMID:13295225;PMID:1540149"
+      - eccodes: "1.3.8.7;1.3.8.8;1.3.8.9;1.3.99.-;1.3.3.6"
+      - references: "PMID:13295225;PMID:1540149;PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265"
       - subsystem:
           - "Beta oxidation of even-chain fatty acids (mitochondrial)"
       - confidence_score: 0
@@ -98168,8 +97530,8 @@
       - upper_bound: 1000
       - gene_reaction_rule: "Echs1 and Mtpα"
       - rxnNotes: ""
-      - eccodes: "4.2.1.17"
-      - references: "PMID:8012501;PMID:8188243;PMID:13295248"
+      - eccodes: "1.3.3.6;4.2.1.17"
+      - references: "PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265;PMID:8012501;PMID:8188243;PMID:13295248"
       - subsystem:
           - "Beta oxidation of even-chain fatty acids (mitochondrial)"
       - confidence_score: 0
@@ -98218,10 +97580,10 @@
           - MAM01803m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "Egm or Mcad"
+      - gene_reaction_rule: "ACOX1 or Acox3 or Egm or Mcad"
       - rxnNotes: ""
-      - eccodes: "1.3.8.7;1.3.99.-"
-      - references: "PMID:13295225;PMID:3597357"
+      - eccodes: "1.3.8.7;1.3.99.-;1.3.3.6"
+      - references: "PMID:13295225;PMID:3597357;PMID:17603022;PMID:1774065;PMID:6240978;PMID:7876265"
       - subsystem:
           - "Beta oxidation of even-chain fatty acids (mitochondrial)"
       - confidence_score: 0
@@ -98286,10 +97648,10 @@
           - MAM02644m: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "Egm or Mcad"
+      - gene_reaction_rule: "ACOX1 or Acox3 or Egm or Mcad"
       - rxnNotes: ""
-      - eccodes: "1.3.8.7;1.3.99.-"
-      - references: "PMID:13295225;PMID:3597357"
+      - eccodes: "1.3.8.7;1.3.99.-;1.3.3.6"
+      - references: "PMID:17603022;PMID:1774065;PMID:13295225;PMID:3597357;PMID:6240978;PMID:7876265"
       - subsystem:
           - "Beta oxidation of even-chain fatty acids (mitochondrial)"
       - confidence_score: 0
@@ -98354,10 +97716,10 @@
           - MAM02122m: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG3902"
+      - gene_reaction_rule: "ACOX1 or Acox3 or CG3902"
       - rxnNotes: ""
-      - eccodes: "1.3.8.5"
-      - references: "PMID:13295225;PMID:3597357"
+      - eccodes: "1.3.8.5;1.3.3.6"
+      - references: "PMID:13295225;PMID:3597357;PMID:17603022;PMID:1774065;PMID:6240978;PMID:7876265"
       - subsystem:
           - "Beta oxidation of even-chain fatty acids (mitochondrial)"
       - confidence_score: 0
@@ -99856,7 +99218,7 @@
           - MAM00099m: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "CG4592 or CG4594 or CG4598 or Dci or Ech1"
+      - gene_reaction_rule: "CG4592 or CG4594 or CG4598 or CG9577 or Dci"
       - rxnNotes: ""
       - eccodes: "5.3.3.8;5.3.3.-"
       - references: "PMID:8486162"
@@ -99868,8 +99230,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM00018x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM03014x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -99936,8 +99298,8 @@
       - name: ""
       - metabolites: !!omap
           - MAM01586x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM03024x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -100347,7 +99709,7 @@
           - MAM00088m: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "CG4592 or CG4594 or CG4598 or Dci or Ech1"
+      - gene_reaction_rule: "CG4592 or CG4594 or CG4598 or CG9577 or Dci"
       - rxnNotes: ""
       - eccodes: "5.3.3.8;5.3.3.-"
       - references: "PMID:8486162"
@@ -100566,7 +99928,7 @@
           - MAM03021m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG4592 or CG4594 or CG4598 or Dci or Ech1"
+      - gene_reaction_rule: "CG4592 or CG4594 or CG4598 or CG9577 or Dci"
       - rxnNotes: ""
       - eccodes: "5.3.3.8;5.3.3.-"
       - references: "PMID:10407780"
@@ -101450,40 +100812,6 @@
       - subsystem:
           - "Terpenoid backbone biosynthesis"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR01644"
-      - name: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming]"
-      - metabolites: !!omap
-          - MAM00036m: 1
-          - MAM00749m: -1
-          - MAM02040m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Mfe2"
-      - rxnNotes: ""
-      - eccodes: "4.2.1.107"
-      - references: "PMID:10709654"
-      - subsystem:
-          - "Steroid metabolism"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR01651"
-      - name: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA:NAD+ oxidoreductase"
-      - metabolites: !!omap
-          - MAM00036m: -1
-          - MAM00748m: 1
-          - MAM02039m: 1
-          - MAM02552m: -1
-          - MAM02553m: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "Mtpα and scu"
-      - rxnNotes: ""
-      - eccodes: "1.1.1.35;1.1.1.211"
-      - references: "PMID:10709654"
-      - subsystem:
-          - "Steroid metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR01924"
       - name: ""
@@ -101630,8 +100958,8 @@
       - id: "MAR02003"
       - name: "3alpha-hydroxy-5alpha-pregnan-20-one:NADP+ 3-oxidoreductase (A-specific)"
       - metabolites: !!omap
-          - MAM00759c: -1
           - MAM01072c: 1
+          - MAM01314c: -1
           - MAM02039c: 1
           - MAM02554c: -1
           - MAM02555c: 1
@@ -109755,23 +109083,6 @@
       - subsystem:
           - "Glycerophospholipid metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR00483"
-      - name: "sn-glycerol 3-phosphate:quinone oxidoreductase"
-      - metabolites: !!omap
-          - MAM01690c: 1
-          - MAM02914c: -1
-          - MAM03102m: 1
-          - MAM03103m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Gpo1"
-      - rxnNotes: ""
-      - eccodes: "1.1.5.3"
-      - references: "PMID:11955283;PMID:2115809;PMID:2923620;PMID:3338458;PMID:340460;PMID:8401296;PMID:8549872;PMID:8579375;PMID:9171333;PMID:9244403;PMID:9559543"
-      - subsystem:
-          - "Glycerophospholipid metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR00482"
       - name: "sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase"
@@ -109785,7 +109096,7 @@
       - gene_reaction_rule: "Gpo1"
       - rxnNotes: ""
       - eccodes: "1.1.5.3"
-      - references: ""
+      - references: "PMID:11955283;PMID:2115809;PMID:2923620;PMID:3338458;PMID:340460;PMID:8401296;PMID:8549872;PMID:8579375;PMID:9171333;PMID:9244403;PMID:9559543"
       - subsystem:
           - "Glycerophospholipid metabolism"
       - confidence_score: 0
@@ -113679,112 +112990,6 @@
       - subsystem:
           - "Ether lipid metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR00024"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01268n: 1
-          - MAM01816n: -1
-          - MAM02757n: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "(HDAC3 and Smr and ebi) or (nej and tai) or (Sin3A and Smr) or (HDAC3 and Sin3A and Smr) or Art4 or Eip75B or Hr3 or Ncoa6 or Tgs1 or tai or usp"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Isolated"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR00025"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01268c: 1
-          - MAM01268n: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "CG10651 or CG30486 or CG34002 or CG8072 or Clk or Fatp2 or Hmgs or Lsd-2 or Men or Rgl or St2"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:12505311;PMID:14999402;PMID:19710929;PMID:17604218;PMID:16476485;PMID:18288277;PMID:16503871;PMID:10529898;PMID:11330046"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR00026"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01268c: -1
-          - MAM01268r: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Hmgcr or Ugt302K1 or Ugt49B2"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:12505311;PMID:14999402;PMID:19710929;PMID:17604218;PMID:16476485;PMID:18288277;PMID:16503871;PMID:10529898;PMID:11330046"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR00027"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01268c: -1
-          - MAM01268m: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Alas or CG3961 or CPT2 or Hmgs or Mcad or whd"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:12505311;PMID:14999402;PMID:19710929;PMID:17604218;PMID:16476485;PMID:18288277;PMID:16503871;PMID:10529898;PMID:11330046"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR00028"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01268c: -1
-          - MAM01268x: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACOX1 or Pex11ab"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:12505311;PMID:14999402;PMID:19710929;PMID:17604218;PMID:16476485;PMID:18288277;PMID:16503871;PMID:10529898;PMID:11330046"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR00029"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01268c: -1
-          - MAM01268e: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "CG9593 or Mdr50 or Snmp2 or Spn77Bb or Spn77Bc or Spn85F or sca"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:12505311;PMID:14999402;PMID:19710929;PMID:17604218;PMID:16476485;PMID:18288277;PMID:16503871;PMID:10529898;PMID:11330046"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR00030"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01268c: -1
-          - MAM01268n: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACC or ACOX1 or CG10116 or CG10163 or CG10357 or CG13282 or CG13562 or CG14034 or CG17191 or CG17192 or CG17292 or CG18258 or CG18641 or CG1986 or CG34447 or CG34448 or CG3961 or CG4582 or CG5162 or CG5665 or CG6271 or CG6277 or CG6283 or CG6295 or CG6296 or CG6431 or CG6472 or CG6675 or CG6847 or CG7367 or CG9593 or CPT2 or Desat1 or FASN2 or Fatp1 or Fatp2 or Gpdh1 or Hmgs or Lsd-2 or Mcad or Mdr50 or Mtp or Pdk or Pex11ab or SREBP or Snmp2 or St2 or Ugt302C1 or Ugt49B1 or Ugt49C1 or Yp1 or Yp2 or Yp3 or bmm or mdy or sca or sxe2 or whd"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:12505311;PMID:14999402;PMID:19710929;PMID:17604218;PMID:16476485;PMID:18288277;PMID:16503871;PMID:10529898;PMID:11330046"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR07200"
       - name: ""
@@ -115442,7 +114647,7 @@
           - MAM02073l: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG6903"
+      - gene_reaction_rule: "Hgsnat"
       - rxnNotes: ""
       - eccodes: "2.3.1.78"
       - references: ""
@@ -115530,7 +114735,7 @@
           - MAM02078l: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG6903"
+      - gene_reaction_rule: "Hgsnat"
       - rxnNotes: ""
       - eccodes: "2.3.1.78"
       - references: ""
@@ -115636,7 +114841,7 @@
           - MAM02060l: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG6903"
+      - gene_reaction_rule: "Hgsnat"
       - rxnNotes: ""
       - eccodes: "2.3.1.78"
       - references: ""
@@ -115742,7 +114947,7 @@
           - MAM02067l: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG6903"
+      - gene_reaction_rule: "Hgsnat"
       - rxnNotes: ""
       - eccodes: "2.3.1.78"
       - references: ""
@@ -118596,38 +117801,6 @@
       - subsystem:
           - "Bile acid biosynthesis"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR01635"
-      - name: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA 25-epimerase"
-      - metabolites: !!omap
-          - MAM00616m: -1
-          - MAM00618m: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Amacr"
-      - rxnNotes: ""
-      - eccodes: "5.1.99.4"
-      - references: "PMID:11864182;PMID:11060344;PMID:10709654;PMID:11060344;PMID:11060344"
-      - subsystem:
-          - "Bile acid biosynthesis"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR01637"
-      - name: ""
-      - metabolites: !!omap
-          - MAM00618m: -1
-          - MAM00749m: 1
-          - MAM02041m: 1
-          - MAM02630m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACOX1 or Acox3"
-      - rxnNotes: ""
-      - eccodes: "1.3.3.6;1.17.99.-"
-      - references: "PMID:10709654"
-      - subsystem:
-          - "Bile acid biosynthesis"
-      - confidence_score: 0
     - !!omap
       - id: "MAR01638"
       - name: ""
@@ -118643,23 +117816,6 @@
       - gene_reaction_rule: "ACOX1 or Acox3"
       - rxnNotes: ""
       - eccodes: "1.3.3.6;1.17.99.-"
-      - references: ""
-      - subsystem:
-          - "Bile acid biosynthesis"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR01639"
-      - name: ""
-      - metabolites: !!omap
-          - MAM00618x: -1
-          - MAM00749x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACOX1 or Acox3"
-      - rxnNotes: ""
-      - eccodes: "1.3.3.6;1.17.99.-"
       - references: "PMID:11356170;PMID:8943006"
       - subsystem:
           - "Bile acid biosynthesis"
@@ -118676,7 +117832,7 @@
       - gene_reaction_rule: "Mfe2"
       - rxnNotes: ""
       - eccodes: "4.2.1.107"
-      - references: "PMID:8902629"
+      - references: "PMID:8902629;PMID:10709654"
       - subsystem:
           - "Bile acid biosynthesis"
       - confidence_score: 0
@@ -118694,7 +117850,7 @@
       - gene_reaction_rule: "Mfe2"
       - rxnNotes: ""
       - eccodes: "1.1.1.35;1.1.1.211"
-      - references: "PMID:11330072"
+      - references: "PMID:11330072;PMID:10709654"
       - subsystem:
           - "Bile acid biosynthesis"
       - confidence_score: 0
@@ -118715,38 +117871,6 @@
       - subsystem:
           - "Bile acid biosynthesis"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR01653"
-      - name: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase"
-      - metabolites: !!omap
-          - MAM00748m: -1
-          - MAM01514m: 1
-          - MAM01597m: -1
-          - MAM02774m: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ScpX or didum"
-      - rxnNotes: ""
-      - eccodes: "2.3.1.176;2.3.1.16"
-      - references: "PMID:1121274;PMID:11356164;PMID:6378901"
-      - subsystem:
-          - "Bile acid biosynthesis"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR01656"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01514c: -1
-          - MAM01514x: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:10884298;PMID:6469982"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR01659"
       - name: ""
@@ -118763,7 +117887,7 @@
       - gene_reaction_rule: "Abcd1 or CG13793 or CG13794 or CG13795 or CG13796 or CG13887 or CG31904 or CG33296 or CaMKI or Idh3g or Slip1"
       - rxnNotes: ""
       - eccodes: ""
-      - references: "PMID:18619829"
+      - references: "PMID:18619829;PMID:6469982"
       - subsystem:
           - "Bile acid biosynthesis"
       - confidence_score: 0
@@ -119113,8 +118237,8 @@
       - metabolites: !!omap
           - MAM00617x: -1
           - MAM00755x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acox57D-d"
@@ -119136,7 +118260,7 @@
       - gene_reaction_rule: "Mfe2"
       - rxnNotes: ""
       - eccodes: "4.2.1.107"
-      - references: "PMID:8902629"
+      - references: "PMID:8902629;PMID:19357427"
       - subsystem:
           - "Bile acid biosynthesis"
       - confidence_score: 0
@@ -119219,7 +118343,7 @@
       - gene_reaction_rule: "St2"
       - rxnNotes: ""
       - eccodes: "2.8.2.14"
-      - references: ""
+      - references: "PMID:19131563;PMID:16949895"
       - subsystem:
           - "Bile acid biosynthesis"
       - confidence_score: 0
@@ -122895,7 +122019,7 @@
           - MAM02630c: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG6910"
+      - gene_reaction_rule: "Miox"
       - rxnNotes: ""
       - eccodes: "1.13.99.1"
       - references: "PMID:15504367;PMID:2226462;PMID:6822903"
@@ -125629,7 +124753,7 @@
       - eccodes: "6.3.4.14"
       - references: ""
       - subsystem:
-          - "Biotin metabolism"
+          - "Fatty acid biosynthesis (even-chain)"
       - confidence_score: 0
     - !!omap
       - id: "MAR07673"
@@ -125646,7 +124770,7 @@
       - eccodes: "6.4.1.2"
       - references: ""
       - subsystem:
-          - "Biotin metabolism"
+          - "Fatty acid biosynthesis (even-chain)"
       - confidence_score: 0
     - !!omap
       - id: "MAR04160"
@@ -131648,9 +130772,9 @@
       - id: "MAR03984"
       - name: "hydrogen-peroxide:hydrogen-peroxide oxidoreductase"
       - metabolites: !!omap
+          - MAM01802x: 1
+          - MAM01803x: -2
           - MAM02040x: 2
-          - MAM02041x: -2
-          - MAM02630x: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "CG43980 or Cat"
@@ -131658,7 +130782,7 @@
       - eccodes: "1.11.1.6"
       - references: "PMID:12054464;PMID:1657986"
       - subsystem:
-          - "Miscellaneous"
+          - "Glyoxylate and dicarboxylate metabolism"
       - confidence_score: 0
     - !!omap
       - id: "MAR04201"
@@ -132051,7 +131175,7 @@
           - MAM02583c: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "Parp or Parp16 or Tnks"
+      - gene_reaction_rule: "Parp1 or Parp16 or Tnks"
       - rxnNotes: ""
       - eccodes: "2.4.2.30"
       - references: ""
@@ -132383,7 +131507,7 @@
           - MAM01864c: 1
           - MAM02034c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "mRNA-cap"
       - rxnNotes: ""
@@ -132624,11 +131748,11 @@
       - id: "MAR09523"
       - name: "delta2-isopentenyl-diphosphate:tRNA isopentenyltransferase"
       - metabolites: !!omap
-          - MAM01706c: 1
-          - MAM02759c: -1
-          - MAM03060c: -1
-          - MAM03083c: 1
-      - lower_bound: -1000
+          - MAM01706c: -1
+          - MAM02759c: 1
+          - MAM03060c: 1
+          - MAM03083c: -1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "CG31381"
       - rxnNotes: ""
@@ -132889,12 +132013,12 @@
       - id: "MAR09546"
       - name: "RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)"
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM02759c: -1
-          - MAM02848c: 1
-          - MAM02849c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM02759c: 1
+          - MAM02848c: -1
+          - MAM02849c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Rtca"
       - rxnNotes: ""
@@ -133219,7 +132343,7 @@
           - MAM03031x: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "Ech1"
+      - gene_reaction_rule: "CG9577"
       - rxnNotes: ""
       - eccodes: "5.3.3.-;5.3.3.8"
       - references: ""
@@ -133251,7 +132375,7 @@
           - MAM02040x: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "Ech1"
+      - gene_reaction_rule: "CG9577"
       - rxnNotes: ""
       - eccodes: ""
       - references: ""
@@ -136965,11 +136089,11 @@
       - metabolites: !!omap
           - MAM02746c: 1
           - MAM02746e: -1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
-      - eccodes: ""
+      - eccodes: "1.14.99.1"
       - references: ""
       - subsystem:
           - "Transport reactions"
@@ -152232,63 +151356,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR06142"
-      - name: ""
-      - metabolites: !!omap
-          - MAM00591c: -1
-          - MAM00591e: 1
-          - MAM01980c: 1
-          - MAM01980e: -1
-          - MAM02046c: 1
-          - MAM02046e: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "Oatp58Da or Oatp58Db or Oatp58Dc"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:14579113;PMID:11076396"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR06143"
-      - name: ""
-      - metabolites: !!omap
-          - MAM00591c: -1
-          - MAM00591e: 1
-          - MAM02046c: 1
-          - MAM02046e: -1
-          - MAM02900c: 1
-          - MAM02900e: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "Oatp58Da or Oatp58Db or Oatp58Dc"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:14579113;PMID:11076396"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR06144"
-      - name: ""
-      - metabolites: !!omap
-          - MAM00591c: -1
-          - MAM00591e: 1
-          - MAM02046c: 1
-          - MAM02046e: -1
-          - MAM02901c: 1
-          - MAM02901e: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "Oatp58Da or Oatp58Db or Oatp58Dc"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:14579113;PMID:11076396"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR06145"
       - name: ""
@@ -153714,25 +152781,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR06220"
-      - name: ""
-      - metabolites: !!omap
-          - MAM00591c: -1
-          - MAM00591e: 1
-          - MAM02026c: 1
-          - MAM02026e: -1
-          - MAM02046c: 1
-          - MAM02046e: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "Oatp58Da or Oatp58Db or Oatp58Dc"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:11076394;PMID:11076396;PMID:14579113"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR06221"
       - name: ""
@@ -154284,21 +153332,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR06252"
-      - name: ""
-      - metabolites: !!omap
-          - MAM00591c: -1
-          - MAM00591e: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:12883891;PMID:12856180;PMID:11023036;PMID:1554704;PMID:18021224;PMID:4553030;PMID:793184;PMID:8725559;PMID:8781017;PMID:12739169"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR06253"
       - name: ""
@@ -164772,23 +163805,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR07758"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01514c: -1
-          - MAM01514m: 1
-          - MAM02039i: -1
-          - MAM02039m: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Acbp1"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR07760"
       - name: ""
@@ -182077,34 +181093,6 @@
       - subsystem:
           - "Pool reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR00032"
-      - name: ""
-      - metabolites: !!omap
-          - MAM00240c: 0.19
-          - MAM00511c: 0.0014
-          - MAM00560c: 0.0024
-          - MAM00656c: 0.0006
-          - MAM01450c: 0.005
-          - MAM01451c: 0.34
-          - MAM02392c: -1
-          - MAM02629c: 0.0008
-          - MAM02684c: 0.0092
-          - MAM02685c: 0.0034
-          - MAM02750c: 0.0016
-          - MAM02808c: 0.0002
-          - MAM02908c: 0.0004
-          - MAM02958c: 0.44
-          - MAM10005c: 0.005
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Pka-C1 or Pp1-87B or fabp or flw"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Pool reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR00021"
       - name: ""
@@ -182143,9 +181131,10 @@
           - MAM03161c: -1
           - MAM03970c: 1
       - lower_bound: 0
-      - upper_bound: 0
+      - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
+      - objective_coefficient: 1
       - eccodes: ""
       - references: ""
       - subsystem:
@@ -182313,7 +181302,7 @@
           - MAM00005c: -1
           - MAM00013c: -1
           - MAM00014x: -1
-          - MAM00029c: -1
+          - MAM00028c: -1
           - MAM00254c: -1
           - MAM00254m: -1
           - MAM00254x: -1
@@ -182500,7 +181489,6 @@
           - MAM00660c: -1
           - MAM00660r: -1
           - MAM00747r: -1
-          - MAM00759c: -1
           - MAM00828r: -1
           - MAM00830c: -1
           - MAM00925c: -1
@@ -182519,6 +181507,7 @@
           - MAM01001x: -1
           - MAM01011c: -1
           - MAM01012c: -1
+          - MAM01314c: -1
           - MAM01792r: -1
           - MAM01794r: -1
           - MAM02469c: -1
@@ -182585,24 +181574,6 @@
       - subsystem:
           - "Ubiquinone synthesis"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR00042"
-      - name: "3-Hydroxyisobutyryl Coenzyme A Hydrolase, Mitochondrial"
-      - metabolites: !!omap
-          - MAM00784m: 1
-          - MAM01597m: 1
-          - MAM02039m: 1
-          - MAM02040m: -1
-          - MAM03226m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: "3.1.2.4"
-      - references: "PMID:8824301"
-      - subsystem:
-          - "Valine, leucine, and isoleucine metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR00043"
       - name: "3-Hydroxyisobutyryl-Coenzyme A Hydrolase"
@@ -182865,24 +181836,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR00059"
-      - name: "Acyl-Coenzyme A Oxidase 2, Branched Chain"
-      - metabolites: !!omap
-          - MAM00037x: 1
-          - MAM00755x: -1
-          - MAM01802x: 1
-          - MAM01803x: -1
-          - MAM02630x: -0.5
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Acox57D-d"
-      - rxnNotes: ""
-      - eccodes: "1.3.3.6"
-      - references: "PMID:11181649"
-      - subsystem:
-          - "Bile acid biosynthesis"
-      - confidence_score: 0
     - !!omap
       - id: "MAR00060"
       - name: "O-Acetylcarnintine Transport into Mitochondria via Diffusion"
@@ -183446,25 +182399,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR00096"
-      - name: "Beta-Ureidopropionase (D-3-Amino-Isobutanoate Forming)"
-      - metabolites: !!omap
-          - MAM00922c: -1
-          - MAM01596c: 1
-          - MAM01633c: 1
-          - MAM02039c: -2
-          - MAM02040c: -1
-          - MAM02579c: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "pyd3"
-      - rxnNotes: ""
-      - eccodes: "3.5.1.6"
-      - references: "PMID:11508704;PMID:5773299"
-      - subsystem:
-          - "Pyrimidine metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR00097"
       - name: "Butyrate Mitochondrial Transport via Proton Symport, Reversible"
@@ -184526,9 +183460,9 @@
       - metabolites: !!omap
           - MAM00558x: 1
           - MAM01742x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
-          - MAM02041x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Daao1"
@@ -185271,20 +184205,6 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR00659"
-      - name: "Exchange of Phytanic Acid"
-      - metabolites: !!omap
-          - MAM03884e: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Exchange/demand reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR00661"
       - name: "Exchange of Phosphatidylserine (Homo Sapiens)"
@@ -185815,12 +184735,12 @@
       - metabolites: !!omap
           - MAM01261x: 4
           - MAM01597x: -4
+          - MAM01802x: -4
+          - MAM01803x: 4
           - MAM02039x: 4
           - MAM02040x: -4
-          - MAM02041x: 4
           - MAM02552x: -4
           - MAM02553x: 4
-          - MAM02630x: -4
           - MAM02644x: 1
           - MAM02678x: -1
       - lower_bound: 0
@@ -185930,12 +184850,12 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM02678x: 1
           - MAM02941x: -1
       - lower_bound: 0
@@ -186114,13 +185034,13 @@
       - metabolites: !!omap
           - MAM01261x: 5
           - MAM01597x: -5
+          - MAM01802x: -2
+          - MAM01803x: 2
           - MAM01934x: -1
           - MAM02039x: 5
           - MAM02040x: -5
-          - MAM02041x: 2
           - MAM02552x: -5
           - MAM02553x: 5
-          - MAM02630x: -2
           - MAM02644x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -186161,12 +185081,12 @@
           - MAM00108x: -1
           - MAM01261x: 5
           - MAM01597x: -5
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 5
           - MAM02040x: -5
-          - MAM02041x: 1
           - MAM02552x: -5
           - MAM02553x: 5
-          - MAM02630x: -1
           - MAM02644x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -186207,12 +185127,12 @@
           - MAM01261x: 1
           - MAM01597x: -1
           - MAM01773x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM02941x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -186364,12 +185284,12 @@
           - MAM01261x: 1
           - MAM01364x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "(ACOX1 and Mfe2) or ACOX1"
@@ -186410,12 +185330,12 @@
           - MAM00103x: 1
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "(ACOX1 and Mfe2) or ACOX1"
@@ -186474,12 +185394,12 @@
           - MAM01261x: 2
           - MAM01597x: -2
           - MAM01773x: 1
+          - MAM01802x: -2
+          - MAM01803x: 2
           - MAM02039x: 2
           - MAM02040x: -2
-          - MAM02041x: 2
           - MAM02552x: -2
           - MAM02553x: 2
-          - MAM02630x: -2
           - MAM02971x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -186497,12 +185417,12 @@
           - MAM00025x: -1
           - MAM01261x: 3
           - MAM01597x: -3
+          - MAM01802x: -3
+          - MAM01803x: 3
           - MAM02039x: 3
           - MAM02040x: -3
-          - MAM02041x: 3
           - MAM02552x: -3
           - MAM02553x: 3
-          - MAM02630x: -3
           - MAM02647x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -186521,12 +185441,12 @@
           - MAM00131x: -1
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "(ACOX1 and Mfe2) or ACOX1"
@@ -186544,12 +185464,12 @@
           - MAM00134x: -1
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "(ACOX1 and Mfe2) or ACOX1"
@@ -186567,12 +185487,12 @@
           - MAM00110x: -1
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "(ACOX1 and Mfe2) or ACOX1"
@@ -186590,12 +185510,12 @@
           - MAM00113x: -1
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "(ACOX1 and Mfe2) or ACOX1"
@@ -186611,13 +185531,13 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02110x: -1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM02971x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -186988,8 +185908,8 @@
       - upper_bound: 1000
       - gene_reaction_rule: "Gpo1"
       - rxnNotes: ""
-      - eccodes: "1.1.99.5"
-      - references: "PMID:11385633;PMID:8549872"
+      - eccodes: "1.1.5.3;1.1.99.5"
+      - references: "PMID:11955283;PMID:2115809;PMID:2923620;PMID:3338458;PMID:340460;PMID:8401296;PMID:8549872;PMID:8579375;PMID:9171333;PMID:9244403;PMID:9559543;PMID:11385633"
       - subsystem:
           - "Glycolysis / Gluconeogenesis"
       - confidence_score: 0
@@ -187554,26 +186474,6 @@
       - subsystem:
           - "Bile acid biosynthesis"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR01458"
-      - name: "Hydroxysteroid (17-Beta) Dehydrogenase 4"
-      - metabolites: !!omap
-          - MAM00748x: 1
-          - MAM00749x: -1
-          - MAM02039x: -1
-          - MAM02040x: 1
-          - MAM02554x: 1
-          - MAM02555x: -1
-          - MAM02630x: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Mfe2"
-      - rxnNotes: ""
-      - eccodes: "3.10.1.1"
-      - references: ""
-      - subsystem:
-          - "Bile acid biosynthesis"
-      - confidence_score: 0
     - !!omap
       - id: "MAR01461"
       - name: "H Transporter, Endoplasmic Reticulum"
@@ -188152,10 +187052,10 @@
           - MAM02519e: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "CG10444"
+      - gene_reaction_rule: "Ih or na or para or ppk11 or ppk22"
       - rxnNotes: ""
       - eccodes: ""
-      - references: "PMID:10893432;PMID:11024018;PMID:11034615;PMID:12679487;PMID:12748858;PMID:1372904;PMID:15546855;PMID:2490366;PMID:7537337;PMID:7789985;PMID:8063771;PMID:8559252;PMID:8806637;PMID:9341168"
+      - references: "PMID:10893432;PMID:11024018;PMID:11034615;PMID:12679487;PMID:12748858;PMID:1372904;PMID:15546855;PMID:2490366;PMID:7537337;PMID:7789985;PMID:8063771;PMID:8559252;PMID:8806637;PMID:9341168;PMID:22573384;PMID:26772908"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -188641,12 +187541,12 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -3
+          - MAM01802x: -2
+          - MAM01803x: 2
           - MAM02039x: 5
           - MAM02040x: -3
-          - MAM02041x: 2
           - MAM02552x: -3
           - MAM02553x: 3
-          - MAM02630x: -2
           - MAM02774x: 2
           - MAM03554x: 1
           - MAM03887x: -1
@@ -188741,21 +187641,6 @@
       - subsystem:
           - "Phenylalanine metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR01617"
-      - name: "Fatty Acid Transport via Diffusion"
-      - metabolites: !!omap
-          - MAM03884c: 1
-          - MAM03884e: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: "1.14.99.1"
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR01618"
       - name: "Phosphatidylinositol 4-Phosphate 3-Kinase, Endoplasmic Reticulum"
@@ -189231,21 +188116,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR01709"
-      - name: "Sterol Carrier Protein 2"
-      - metabolites: !!omap
-          - MAM03554c: -1
-          - MAM03554x: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "ScpX"
-      - rxnNotes: ""
-      - eccodes: "1.5.1.10"
-      - references: "PMID:1703300"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR01711"
       - name: "Peroxisomal Thiolase 2"
@@ -189730,22 +188600,7 @@
       - metabolites: !!omap
           - MAM03142c: 1
           - MAM03142m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR01823"
-      - name: "Vitamin D3 Transport in Mitochondria"
-      - metabolites: !!omap
-          - MAM03142c: -1
-          - MAM03142m: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -190275,25 +189130,6 @@
       - subsystem:
           - "Arginine and proline metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR02027"
-      - name: "L-Cysteine L-Homocysteine-Lyase (Deaminating)"
-      - metabolites: !!omap
-          - MAM01628c: -1
-          - MAM02039c: 1
-          - MAM02040c: -1
-          - MAM02042c: 1
-          - MAM02579c: 1
-          - MAM02819c: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "Cth"
-      - rxnNotes: ""
-      - eccodes: "4.4.1.1"
-      - references: "PMID:10212249;PMID:629532"
-      - subsystem:
-          - "Cysteine and methionine metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR02028"
       - name: "Trans-Hexadec-2-Enoyl Coenzyme A Reductase"
@@ -190312,23 +189148,6 @@
       - subsystem:
           - "Fatty acid oxidation"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR02035"
-      - name: "Palmitoyl Coenzyme A:Oxygen 2-Oxidoreductase"
-      - metabolites: !!omap
-          - MAM00051m: 1
-          - MAM02678m: -1
-          - MAM03102m: 1
-          - MAM03103m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACOX1 or Acadvl or Acox3 or Egm or Mcad"
-      - rxnNotes: ""
-      - eccodes: "1.3.99.3"
-      - references: "PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
     - !!omap
       - id: "MAR02119"
       - name: "L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)"
@@ -190547,24 +189366,6 @@
       - subsystem:
           - "Bile acid biosynthesis"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR02185"
-      - name: " (3R)-3-Hydroxytetradecanoyl-[Acyl-Carrier-Protein]:NADP+ Oxidoreductase Fatty Acid Biosynthesis"
-      - metabolites: !!omap
-          - MAM00905c: 1
-          - MAM02039c: 1
-          - MAM02130c: -1
-          - MAM02554c: -1
-          - MAM02555c: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "FASN2"
-      - rxnNotes: ""
-      - eccodes: "2.3.1.85"
-      - references: "PMID:11750882;PMID:4452359;PMID:6137188;PMID:7567999;PMID:7834997;PMID:8962082"
-      - subsystem:
-          - "Fatty acid biosynthesis"
-      - confidence_score: 0
     - !!omap
       - id: "MAR02186"
       - name: "2-Amino-4-Hydroxy-6- (Erythro-1, 2, 3-Trihydroxypropyl) Dihydropteridine Triphosphate Phosphohydrolase (Alkaline Optimum)"
@@ -190943,41 +189744,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR02276"
-      - name: "ATP-Binding Cassette (ABC) Tcdb:3.A.1.208.2"
-      - metabolites: !!omap
-          - MAM01285c: 1
-          - MAM01371c: -1
-          - MAM02039c: 1
-          - MAM02040c: -1
-          - MAM02751c: 1
-          - MAM03318c: -1
-          - MAM03318e: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "MRP"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:14716480;PMID:15209530;PMID:15297262"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR02277"
-      - name: "Facilitated Diffusion"
-      - metabolites: !!omap
-          - MAM03318c: -1
-          - MAM03318r: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:15975683"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR02278"
       - name: "Facilitated Diffusion"
@@ -191563,7 +190329,7 @@
           - MAM02751e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG10483 or CG7536"
+      - gene_reaction_rule: "CG7536 or PXo"
       - rxnNotes: ""
       - eccodes: "4.2.1.1"
       - references: "PMID:10938543;PMID:11493685;PMID:12713833;PMID:12747791;PMID:14640555;PMID:17259996;PMID:17504134;PMID:17826101;PMID:7011879;PMID:7672338"
@@ -191581,7 +190347,7 @@
           - MAM02990m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx-2)"
+      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx2)"
       - rxnNotes: ""
       - eccodes: "1.17.4.1"
       - references: "PMID:5553404;PMID:5671058"
@@ -191599,31 +190365,13 @@
           - MAM02990m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx-2)"
+      - gene_reaction_rule: "(CG8517 and RnrL and RnrS) or (RnrL and RnrS and Trx2)"
       - rxnNotes: ""
       - eccodes: "1.17.4.1"
       - references: "PMID:5553404;PMID:5671058"
       - subsystem:
           - "Miscellaneous"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR02358"
-      - name: "NADPH:Oxidized-Thioredoxin Oxidoreductase"
-      - metabolites: !!omap
-          - MAM02039m: 1
-          - MAM02554m: -1
-          - MAM02555m: 1
-          - MAM02666m: 1
-          - MAM02990m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Trxr1 or Trxr2"
-      - rxnNotes: ""
-      - eccodes: "1.8.1.9"
-      - references: "PMID:5553404;PMID:5671058"
-      - subsystem:
-          - "Miscellaneous"
-      - confidence_score: 0
     - !!omap
       - id: "MAR02360"
       - name: "Active Transport"
@@ -191639,108 +190387,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR02366"
-      - name: "Acyl-CoA Oxidase"
-      - metabolites: !!omap
-          - MAM01412m: -1
-          - MAM01622m: 1
-          - MAM03102m: 1
-          - MAM03103m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACOX1 or Acox3"
-      - rxnNotes: ""
-      - eccodes: "1.3.3.6"
-      - references: "PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265"
-      - subsystem:
-          - "Miscellaneous"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR02367"
-      - name: "Acyl-CoA Oxidase"
-      - metabolites: !!omap
-          - MAM00042m: 1
-          - MAM02345m: -1
-          - MAM03102m: 1
-          - MAM03103m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACOX1 or Acox3"
-      - rxnNotes: ""
-      - eccodes: "1.3.3.6"
-      - references: "PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR02369"
-      - name: "Acyl-CoA Oxidase"
-      - metabolites: !!omap
-          - MAM00059m: 1
-          - MAM02644m: -1
-          - MAM03102m: 1
-          - MAM03103m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACOX1 or Acox3"
-      - rxnNotes: ""
-      - eccodes: "1.3.3.6"
-      - references: "PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR02370"
-      - name: "Acyl-CoA Oxidase"
-      - metabolites: !!omap
-          - MAM00066m: 1
-          - MAM02495m: -1
-          - MAM03102m: 1
-          - MAM03103m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACOX1 or Acox3"
-      - rxnNotes: ""
-      - eccodes: "1.3.3.6"
-      - references: "PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR02372"
-      - name: "Acyl-CoA Oxidase"
-      - metabolites: !!omap
-          - MAM00053m: 1
-          - MAM02122m: -1
-          - MAM03102m: 1
-          - MAM03103m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACOX1 or Acox3"
-      - rxnNotes: ""
-      - eccodes: "1.3.3.6"
-      - references: "PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR02373"
-      - name: "Acyl-CoA Oxidase"
-      - metabolites: !!omap
-          - MAM00039m: 1
-          - MAM01650m: -1
-          - MAM03102m: 1
-          - MAM03103m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACOX1 or Acox3"
-      - rxnNotes: ""
-      - eccodes: "1.3.3.6"
-      - references: "PMID:17603022;PMID:1774065;PMID:3597357;PMID:6240978;PMID:7876265"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
     - !!omap
       - id: "MAR02375"
       - name: "Long-Chain-Acyl Coenzyme A Dehydrogenase"
@@ -191845,63 +190491,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR02390"
-      - name: "Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.14"
-      - metabolites: !!omap
-          - MAM01980c: -1
-          - MAM01980e: 1
-          - MAM02046c: -1
-          - MAM02046e: 1
-          - MAM03318c: 1
-          - MAM03318e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Oatp58Da or Oatp58Db or Oatp58Dc"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:11076394;PMID:11076396;PMID:14579113"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR02392"
-      - name: "Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.14"
-      - metabolites: !!omap
-          - MAM02046c: -1
-          - MAM02046e: 1
-          - MAM02900c: -1
-          - MAM02900e: 1
-          - MAM03318c: 1
-          - MAM03318e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Oatp58Da or Oatp58Db or Oatp58Dc"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:11076394;PMID:11076396;PMID:14579113"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR02394"
-      - name: "Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.14"
-      - metabolites: !!omap
-          - MAM02046c: -1
-          - MAM02046e: 1
-          - MAM02901c: -1
-          - MAM02901e: 1
-          - MAM03318c: 1
-          - MAM03318e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Oatp58Da or Oatp58Db or Oatp58Dc"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:11076394;PMID:11076396;PMID:14579113"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR02396"
       - name: "Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5"
@@ -191912,7 +190501,7 @@
           - MAM01980e: 1
           - MAM02046c: -1
           - MAM02046e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: "Oatp58Da or Oatp58Db or Oatp58Dc"
       - rxnNotes: ""
@@ -191931,7 +190520,7 @@
           - MAM02046e: 1
           - MAM02900c: -1
           - MAM02900e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: "Oatp58Da or Oatp58Db or Oatp58Dc"
       - rxnNotes: ""
@@ -191950,7 +190539,7 @@
           - MAM02046e: 1
           - MAM02901c: -1
           - MAM02901e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: "Oatp58Da or Oatp58Db or Oatp58Dc"
       - rxnNotes: ""
@@ -192525,7 +191114,7 @@
           - MAM02986m: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "CG17691 or CG7430 or CG8199"
+      - gene_reaction_rule: "BckdhA or BckdhB or CG7430"
       - rxnNotes: ""
       - eccodes: "1.8.1.4"
       - references: "PMID:11013238;PMID:9665099"
@@ -192956,7 +191545,7 @@
           - MAM02387m: -1
           - MAM02391m: 1
           - MAM02759m: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961"
       - rxnNotes: ""
@@ -192975,7 +191564,7 @@
           - MAM02387x: -1
           - MAM02391x: 1
           - MAM02759x: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961"
       - rxnNotes: ""
@@ -192996,10 +191585,10 @@
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
       - rxnNotes: ""
-      - eccodes: "1.3.99.13"
+      - eccodes: "1.3.99.13;1.3.3.6"
       - references: "PMID:10407780;PMID:11356167;PMID:8973539"
       - subsystem:
-          - "Fatty acid oxidation"
+          - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)"
       - confidence_score: 0
     - !!omap
       - id: "MAR02808"
@@ -193013,10 +191602,10 @@
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
       - rxnNotes: ""
-      - eccodes: "1.3.99.13"
+      - eccodes: "1.3.99.13;1.3.3.6"
       - references: "PMID:10407780;PMID:11356167;PMID:8973539"
       - subsystem:
-          - "Fatty acid oxidation"
+          - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)"
       - confidence_score: 0
     - !!omap
       - id: "MAR02810"
@@ -193030,10 +191619,10 @@
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
       - rxnNotes: ""
-      - eccodes: "1.3.99.13"
+      - eccodes: "1.3.99.13;1.3.3.6"
       - references: "PMID:10407780;PMID:11356167;PMID:8973539"
       - subsystem:
-          - "Fatty acid oxidation"
+          - "Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)"
       - confidence_score: 0
     - !!omap
       - id: "MAR02818"
@@ -193048,7 +191637,7 @@
       - gene_reaction_rule: "ACOX1 or Acox3"
       - rxnNotes: ""
       - eccodes: "1.3.99.13"
-      - references: "PMID:10407780;PMID:11356167;PMID:8973539"
+      - references: "PMID:10407780;PMID:11356167;PMID:8973539;PMID:18536048;PMID:17458872"
       - subsystem:
           - "Fatty acid oxidation"
       - confidence_score: 0
@@ -194624,10 +193213,10 @@
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
       - rxnNotes: ""
-      - eccodes: "1.3.99.3"
+      - eccodes: "1.3.99.3;1.3.3.6"
       - references: "PMID:1047780;PMID:11135616;PMID:8973539"
       - subsystem:
-          - "Fatty acid oxidation"
+          - "Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)"
       - confidence_score: 0
     - !!omap
       - id: "MAR03289"
@@ -194641,10 +193230,10 @@
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 or Acox3"
       - rxnNotes: ""
-      - eccodes: "1.3.99.3"
+      - eccodes: "1.3.99.3;1.3.3.6"
       - references: "PMID:1047780;PMID:11135616;PMID:8973539"
       - subsystem:
-          - "Fatty acid oxidation"
+          - "Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)"
       - confidence_score: 0
     - !!omap
       - id: "MAR03291"
@@ -194897,7 +193486,7 @@
           - MAM03359m: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "Ech1"
+      - gene_reaction_rule: "CG9577"
       - rxnNotes: ""
       - eccodes: "2.3.1.16"
       - references: "PMID:10407780;PMID:7775433"
@@ -195049,7 +193638,7 @@
           - MAM02746c: -1
           - MAM02759c: 1
           - MAM03362c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -195068,7 +193657,7 @@
           - MAM01597c: -1
           - MAM02759c: 1
           - MAM02766c: -1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -195512,7 +194101,7 @@
       - name: ""
       - metabolites: !!omap
           - MAM00119c: -1
-          - MAM00902c: 1
+          - MAM00853c: 1
           - MAM01596c: 1
           - MAM01597c: 1
           - MAM02039c: 1
@@ -195545,33 +194134,15 @@
       - subsystem:
           - "Fatty acid oxidation"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03441"
-      - name: ""
-      - metabolites: !!omap
-          - MAM00681c: -1
-          - MAM02039c: -1
-          - MAM02554c: 1
-          - MAM02555c: -1
-          - MAM03354c: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:10970790"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03442"
       - name: ""
       - metabolites: !!omap
+          - MAM00131r: 1
           - MAM00681r: -1
           - MAM02039r: -1
           - MAM02554r: 1
           - MAM02555r: -1
-          - MAM03354r: 1
       - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: "CG31522 or CG31523 or Elovl7"
@@ -196361,22 +194932,6 @@
       - subsystem:
           - "Fatty acid biosynthesis"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03754"
-      - name: "Enoyl Coenzyme A Hydratase"
-      - metabolites: !!omap
-          - MAM00749m: -1
-          - MAM02040m: -1
-          - MAM03367m: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "Echs1 or Mtpα or Mtpβ"
-      - rxnNotes: ""
-      - eccodes: "4.2.1.17"
-      - references: "PMID:10709654"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03758"
       - name: "3-Hydroxyacyl Coenzyme A Dehydrogenase"
@@ -196395,33 +194950,15 @@
       - subsystem:
           - "Fatty acid oxidation"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03760"
-      - name: "3-Hydroxyacyl Coenzyme A Dehydrogenase"
-      - metabolites: !!omap
-          - MAM02039m: 1
-          - MAM02552m: -1
-          - MAM02553m: 1
-          - MAM03367m: -1
-          - MAM03368m: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "Mfe2 or scu"
-      - rxnNotes: ""
-      - eccodes: "1.1.1.35"
-      - references: "PMID:10709654"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03764"
       - name: "3-Hydroxyacyl Coenzyme A Dehydrogenase"
       - metabolites: !!omap
+          - MAM00748x: 1
           - MAM02039x: 1
           - MAM02552x: -1
           - MAM02553x: 1
           - MAM03367x: -1
-          - MAM03368x: 1
       - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: "Mfe2"
@@ -197124,7 +195661,7 @@
       - id: "MAR03914"
       - name: ""
       - metabolites: !!omap
-          - MAM03325c: -1
+          - MAM00684c: -1
           - MAM03405c: 1
           - MAM03510c: 1
       - lower_bound: -1000
@@ -197513,8 +196050,8 @@
       - id: "MAR04001"
       - name: "Acyl Coenzyme A Oxidase"
       - metabolites: !!omap
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM03021x: 1
           - MAM03352x: -1
       - lower_bound: 0
@@ -198128,20 +196665,6 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR04144"
-      - name: "Exchange of Chenodeoxycholate"
-      - metabolites: !!omap
-          - MAM03318e: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Exchange/demand reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR04146"
       - name: "Exchange of Taurolithocholate"
@@ -199372,23 +197895,6 @@
       - subsystem:
           - "Fatty acid oxidation"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR04506"
-      - name: "Production of Dodecanoylcarnitine"
-      - metabolites: !!omap
-          - MAM01597c: 1
-          - MAM02345c: -1
-          - MAM02348c: -1
-          - MAM03540c: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "whd"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:12828998;PMID:9498103;PMID:3955080"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
     - !!omap
       - id: "MAR04508"
       - name: "Production of Dodecenoylcarnitine"
@@ -200513,7 +199019,7 @@
       - id: "MAR04923"
       - name: "Exchange of Lauroyl Carnitine"
       - metabolites: !!omap
-          - MAM03540e: -1
+          - MAM01729e: -1
       - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -200621,23 +199127,6 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR04966"
-      - name: "Fatty Acid Beta Oxidation (C10:1->C10:2), Peroxisomal"
-      - metabolites: !!omap
-          - MAM00678x: 1
-          - MAM00980x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ACOX1"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:18536048;PMID:17458872"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
     - !!omap
       - id: "MAR04967"
       - name: "Fatty Acid Beta Oxidation (C10:1->C8), Mitochondrial"
@@ -200701,8 +199190,8 @@
       - id: "MAR04981"
       - name: "Fatty Acid Beta Oxidation (C10:2->C10:3), Peroxisomal"
       - metabolites: !!omap
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM03542x: -1
           - MAM03545x: 1
       - lower_bound: 0
@@ -200834,12 +199323,12 @@
           - MAM01261x: 1
           - MAM01597x: -1
           - MAM01650x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM02644x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -200856,12 +199345,12 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM03922x: 1
           - MAM03924x: -1
       - lower_bound: 0
@@ -200878,12 +199367,12 @@
       - name: "Fatty Acid Beta Oxidation (C11Br->C9Br), Peroxisomal"
       - metabolites: !!omap
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM02774x: 1
           - MAM03554x: 1
           - MAM04004x: -1
@@ -201116,13 +199605,13 @@
           - MAM01261x: 1
           - MAM01597x: -1
           - MAM01650x: 1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02345x: -1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 and Mfe2"
@@ -201156,12 +199645,12 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM03491x: -1
           - MAM03924x: 1
       - lower_bound: 0
@@ -201229,12 +199718,12 @@
           - MAM00948x: -1
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM04004x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -201299,12 +199788,12 @@
           - MAM01141x: -1
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 and Mfe2"
@@ -201361,12 +199850,12 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM03203x: 1
           - MAM03978x: -1
       - lower_bound: 0
@@ -201425,12 +199914,12 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM03211x: 1
           - MAM03288x: -1
       - lower_bound: 0
@@ -201471,14 +199960,14 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02345x: 1
           - MAM02495x: -1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 and Mfe2"
@@ -201512,12 +200001,12 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM03491x: 1
           - MAM03492x: -1
       - lower_bound: 0
@@ -201535,12 +200024,12 @@
       - metabolites: !!omap
           - MAM00948x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM02774x: 1
           - MAM03887x: -1
       - lower_bound: 0
@@ -201646,12 +200135,12 @@
           - MAM01191x: -1
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 and Mfe2"
@@ -201785,8 +200274,8 @@
       - id: "MAR05196"
       - name: "Fatty Acid Beta Oxidation (C16:3->C16:4), Peroxisomal"
       - metabolites: !!omap
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM03274x: -1
           - MAM03653x: 1
       - lower_bound: 0
@@ -201912,8 +200401,8 @@
       - id: "MAR05300"
       - name: "Fatty Acid Beta Oxidation (C16:4->C16:5), Peroxisomal"
       - metabolites: !!omap
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM03273x: -1
           - MAM03656x: 1
       - lower_bound: 0
@@ -201984,13 +200473,13 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02495x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM02678x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -202025,12 +200514,12 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM03492x: 1
           - MAM03655x: -1
       - lower_bound: 0
@@ -202114,12 +200603,12 @@
           - MAM01191x: 1
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM03789x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -202307,12 +200796,12 @@
           - MAM00108x: -1
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM03273x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -202413,12 +200902,12 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM03567x: -1
           - MAM03789x: 1
       - lower_bound: 0
@@ -202457,8 +200946,8 @@
       - id: "MAR05374"
       - name: "Fatty Acid Beta Oxidation (C20:4->C20:5), Peroxisomal"
       - metabolites: !!omap
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM03570x: 1
           - MAM03571x: -1
       - lower_bound: 0
@@ -202520,12 +201009,12 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM03555x: -1
           - MAM03567x: 1
       - lower_bound: 0
@@ -202601,8 +201090,8 @@
       - name: "Fatty Acid Beta Oxidation (C22:5->C22:6), Peroxisomal"
       - metabolites: !!omap
           - MAM00093x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM03557x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -202704,12 +201193,12 @@
           - MAM01597x: -1
           - MAM01725x: -1
           - MAM01773x: 1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 and Mfe2"
@@ -202726,12 +201215,12 @@
           - MAM00025x: -1
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM03555x: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -202749,12 +201238,12 @@
           - MAM01261x: 1
           - MAM01597x: -1
           - MAM01725x: 1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM02971x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -202980,13 +201469,13 @@
           - MAM01261x: 1
           - MAM01412x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02122x: -1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ACOX1 and Mfe2"
@@ -203002,12 +201491,12 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM02944x: 1
           - MAM03409x: -1
       - lower_bound: 0
@@ -203071,12 +201560,12 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM03659x: 1
           - MAM03794x: -1
       - lower_bound: 0
@@ -203117,13 +201606,13 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02122x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM02644x: -1
       - lower_bound: 0
       - upper_bound: 1000
@@ -203140,12 +201629,12 @@
       - metabolites: !!omap
           - MAM01261x: 1
           - MAM01597x: -1
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02039x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
           - MAM02552x: -1
           - MAM02553x: 1
-          - MAM02630x: -1
           - MAM03409x: 1
           - MAM03922x: -1
       - lower_bound: 0
@@ -207803,25 +206292,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR09887"
-      - name: "Glutamine Transport by B0At3"
-      - metabolites: !!omap
-          - MAM01442c: 1
-          - MAM01442e: -1
-          - MAM01975c: 1
-          - MAM01975e: -1
-          - MAM02519c: 1
-          - MAM02519e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "CG43066"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR09888"
       - name: "Glutamate Transport by B0At3"
@@ -210548,26 +209018,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR10164"
-      - name: "Transport of (8Z, 11Z, 14Z)-Eicosatrienoic Acid, Active Transport"
-      - metabolites: !!omap
-          - MAM01285c: 1
-          - MAM01371c: -1
-          - MAM02039c: 1
-          - MAM02040c: -1
-          - MAM02751c: 1
-          - MAM03332c: -1
-          - MAM03332e: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:24653705;PMID:9831619;PMID:5555776;PMID:23104810"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR10165"
       - name: "Transport of 15-Hydroxy- (8Z, 11Z, 13E)-Eicosatrienoate, Active Transport"
@@ -214534,20 +212984,6 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR10433"
-      - name: "Exchangefor (8Z, 11Z, 14Z)-Eicosatrienoic Acid"
-      - metabolites: !!omap
-          - MAM03332e: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Exchange/demand reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR10434"
       - name: "Exchange of Laurate"
@@ -214710,35 +213146,17 @@
       - subsystem:
           - "Glycine, serine and threonine metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR10447"
-      - name: "Formation of Sulfochenodeoxycholate"
-      - metabolites: !!omap
-          - MAM02039c: 1
-          - MAM02681c: 1
-          - MAM02682c: -1
-          - MAM02950c: 1
-          - MAM03318c: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "St2"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:19131563;PMID:16949895"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR10448"
       - name: "Formation of 7-Ketolithocholate"
       - metabolites: !!omap
+          - MAM01435c: -1
           - MAM02039c: -1
           - MAM02040c: 2
           - MAM02554c: 1
           - MAM02555c: -1
           - MAM02630c: -1
           - MAM03313c: 1
-          - MAM03318c: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -215037,22 +213455,7 @@
       - metabolites: !!omap
           - MAM03837c: -1
           - MAM03837e: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:21343587"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR10467"
-      - name: "Uptake of P-Cresol Sulfate"
-      - metabolites: !!omap
-          - MAM03837c: 1
-          - MAM03837e: -1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -215067,27 +213470,12 @@
       - metabolites: !!omap
           - MAM03215c: 1
           - MAM03215e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:12904817"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR10469"
-      - name: "3-Hydroxycinanmic Acid Secretion"
-      - metabolites: !!omap
-          - MAM03215c: -1
-          - MAM03215e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - eccodes: ""
-      - references: "PMID:12904817"
+      - references: "PMID:12904817;PMID:12663291"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -215095,24 +213483,9 @@
       - id: "MAR10470"
       - name: "3-Hydroxyphenylpropionic Acid Uptake"
       - metabolites: !!omap
-          - MAM03231c: 1
           - MAM03231e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:12904817;PMID:12663291"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR10471"
-      - name: "3-Hydroxyphenylpropionic Acid Secretion"
-      - metabolites: !!omap
-          - MAM03231c: -1
-          - MAM03231e: 1
-      - lower_bound: 0
+          - MAM03232c: 1
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -227927,8 +226300,8 @@
       - id: "MAR11266"
       - name: "Transport of Lauroyl Carnitine"
       - metabolites: !!omap
-          - MAM03540c: 1
-          - MAM03540e: -1
+          - MAM01729c: 1
+          - MAM01729e: -1
       - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -231821,14 +230194,14 @@
       - id: "MAR11529"
       - name: "Formation of 3-Hydroxy-Adipoyl Coa"
       - metabolites: !!omap
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
           - MAM03213x: 1
           - MAM03409x: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(ACOX1 and Ech1) or ACOX1"
+      - gene_reaction_rule: "(ACOX1 and CG9577) or ACOX1"
       - rxnNotes: "https://www.springer.com/gp/book/9789400957800"
       - eccodes: "1.3.3.6;4.2.1.17"
       - references: "PMID:2739576"
@@ -231901,14 +230274,14 @@
       - id: "MAR11534"
       - name: "Formation of 3-Hydroxy-Sebacoyl Coa"
       - metabolites: !!omap
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
           - MAM03259x: 1
           - MAM03924x: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(ACOX1 and Ech1) or ACOX1"
+      - gene_reaction_rule: "(ACOX1 and CG9577) or ACOX1"
       - rxnNotes: ""
       - eccodes: "1.3.3.6;4.2.1.17"
       - references: "PMID:8295400;PMID:14708889;PMID:1444166"
@@ -231981,14 +230354,14 @@
       - id: "MAR11539"
       - name: "Formation of 3-Hydoxy-Suberyl Coa"
       - metabolites: !!omap
+          - MAM01802x: -1
+          - MAM01803x: 1
           - MAM02040x: -1
-          - MAM02041x: 1
-          - MAM02630x: -1
           - MAM03261x: 1
           - MAM03922x: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(ACOX1 and Ech1) or ACOX1"
+      - gene_reaction_rule: "(ACOX1 and CG9577) or ACOX1"
       - rxnNotes: ""
       - eccodes: "1.3.3.6;4.2.1.17"
       - references: ""
@@ -232705,12 +231078,12 @@
       - metabolites: !!omap
           - MAM02750c: -1
           - MAM02750e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:8145081"
+      - eccodes: "3.6.3.44;3.6.3.1"
+      - references: "PMID:8145081;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -232720,12 +231093,12 @@
       - metabolites: !!omap
           - MAM03803c: -1
           - MAM03803e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - eccodes: ""
-      - references: "PMID:8145081"
+      - references: "PMID:8145081;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -232735,12 +231108,12 @@
       - metabolites: !!omap
           - MAM03802c: -1
           - MAM03802e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - eccodes: ""
-      - references: "PMID:8145081"
+      - references: "PMID:8145081;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -232750,12 +231123,12 @@
       - metabolites: !!omap
           - MAM03804c: -1
           - MAM03804e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - eccodes: ""
-      - references: "PMID:8145081"
+      - references: "PMID:8145081;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233620,12 +231993,12 @@
       - metabolites: !!omap
           - MAM03936c: -1
           - MAM03936e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
+      - eccodes: "3.6.3.1"
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233635,12 +232008,12 @@
       - metabolites: !!omap
           - MAM03937c: -1
           - MAM03937e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
+      - eccodes: "3.6.3.1"
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233650,12 +232023,12 @@
       - metabolites: !!omap
           - MAM03938c: -1
           - MAM03938e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
+      - eccodes: "3.6.3.1"
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233665,12 +232038,12 @@
       - metabolites: !!omap
           - MAM03940c: -1
           - MAM03940e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
+      - eccodes: "3.6.3.1"
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233680,12 +232053,12 @@
       - metabolites: !!omap
           - MAM03939c: -1
           - MAM03939e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
+      - eccodes: "3.6.3.1"
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233695,12 +232068,12 @@
       - metabolites: !!omap
           - MAM03941c: -1
           - MAM03941e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
-      - eccodes: "2.3.1.13"
-      - references: ""
+      - eccodes: "2.3.1.13;3.6.3.1"
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233710,12 +232083,12 @@
       - metabolites: !!omap
           - MAM03943c: -1
           - MAM03943e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233725,12 +232098,12 @@
       - metabolites: !!omap
           - MAM03942c: -1
           - MAM03942e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233740,12 +232113,12 @@
       - metabolites: !!omap
           - MAM03945c: -1
           - MAM03945e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233755,12 +232128,12 @@
       - metabolites: !!omap
           - MAM03944c: -1
           - MAM03944e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233770,12 +232143,12 @@
       - metabolites: !!omap
           - MAM03946c: -1
           - MAM03946e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233785,12 +232158,12 @@
       - metabolites: !!omap
           - MAM03948c: -1
           - MAM03948e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233800,12 +232173,12 @@
       - metabolites: !!omap
           - MAM03947c: -1
           - MAM03947e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - eccodes: "2.3.1.13"
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233815,12 +232188,12 @@
       - metabolites: !!omap
           - MAM03949c: -1
           - MAM03949e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233830,12 +232203,12 @@
       - metabolites: !!omap
           - MAM03950c: -1
           - MAM03950e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233845,12 +232218,12 @@
       - metabolites: !!omap
           - MAM03951c: -1
           - MAM03951e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
       - eccodes: ""
-      - references: ""
+      - references: "PMID:11581500;PMID:10856719"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -233908,66 +232281,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11649"
-      - name: "Transport of 1-Phosphatidyl-1D-Myo-Inositol, Vescicular"
-      - metabolites: !!omap
-          - MAM02750c: 1
-          - MAM02750e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: "3.6.3.44;3.6.3.1"
-      - references: "PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR11650"
-      - name: "Transport of 1-Arachidonoylglycerophosphoinositol, Vescicular"
-      - metabolites: !!omap
-          - MAM03802c: 1
-          - MAM03802e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR11651"
-      - name: "Transport of 1-Palmitoylglycerophosphoinositol, Vescicular"
-      - metabolites: !!omap
-          - MAM03803c: 1
-          - MAM03803e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR11652"
-      - name: "Transport of 1-Stearoylglycerophosphoinositol, Vescicular"
-      - metabolites: !!omap
-          - MAM03804c: 1
-          - MAM03804e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11653"
       - name: "Transport of 2-Linoleoylglycerophosphocholine, Vescicular"
@@ -234638,21 +232951,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11697"
-      - name: "Transport of Sphingomyelin (D18:0/24:1) Vescicular Transport"
-      - metabolites: !!omap
-          - MAM03936c: 1
-          - MAM03936e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: "3.6.3.1"
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11698"
       - name: "Transport of Sphingomyelin (D18:1/14:0), Active Transport"
@@ -234673,21 +232971,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11699"
-      - name: "Transport of Sphingomyelin (D18:1/14:0), Vescicular Transport"
-      - metabolites: !!omap
-          - MAM03937c: 1
-          - MAM03937e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: "3.6.3.1"
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11700"
       - name: "Transport of Sphingomyelin (D18:1/15:0), Active Transport"
@@ -234708,21 +232991,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11701"
-      - name: "Transport of Sphingomyelin (D18:1/15:0), Vescicular Transport"
-      - metabolites: !!omap
-          - MAM03938c: 1
-          - MAM03938e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: "3.6.3.1"
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11702"
       - name: "Transport of Sphingomyelin (D18:1/16:0), Active Transport"
@@ -234743,21 +233011,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11703"
-      - name: "Transport of Sphingomyelin (D18:1/16:0), Vescicular Transport"
-      - metabolites: !!omap
-          - MAM03940c: 1
-          - MAM03940e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: "3.6.3.1"
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11704"
       - name: "Transport of Sphingomyelin (D18:1/16:1), Active Transport"
@@ -234778,21 +233031,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11705"
-      - name: "Transport of Sphingomyelin (D18:1/16:1), Vescicular Transport"
-      - metabolites: !!omap
-          - MAM03939c: 1
-          - MAM03939e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: "3.6.3.1"
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11706"
       - name: "Transport of Sphingomyelin (D18:1/17:0), Active"
@@ -234813,21 +233051,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11707"
-      - name: "Transport of Sphingomyelin (D18:1/17:0), Vescicular"
-      - metabolites: !!omap
-          - MAM03941c: 1
-          - MAM03941e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: "3.6.3.1"
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11708"
       - name: "Transport of Sphingomyelin (D18:1/18:0), Active"
@@ -234848,21 +233071,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11709"
-      - name: "Transport of Sphingomyelin (D18:1/18:0), Vescicular"
-      - metabolites: !!omap
-          - MAM03943c: 1
-          - MAM03943e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11710"
       - name: "Transport of Sphingomyelin (D18:1/18:1), Active"
@@ -234883,21 +233091,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11711"
-      - name: "Transport of Sphingomyelin (D18:1/18:1), Vescicular"
-      - metabolites: !!omap
-          - MAM03942c: 1
-          - MAM03942e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11712"
       - name: "Transport of Sphingomyelin (D18:1/20:0), Active"
@@ -234918,21 +233111,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11713"
-      - name: "Transport of Sphingomyelin (D18:1/20:0), Vescicular"
-      - metabolites: !!omap
-          - MAM03945c: 1
-          - MAM03945e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11714"
       - name: "Transport of Sphingomyelin (D18:1/20:1), Active"
@@ -234953,21 +233131,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11715"
-      - name: "Transport of Sphingomyelin (D18:1/20:1), Vescicular"
-      - metabolites: !!omap
-          - MAM03944c: 1
-          - MAM03944e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11716"
       - name: "Transport of Sphingomyelin (D18:1/21:0), Active"
@@ -234988,21 +233151,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11717"
-      - name: "Transport of Sphingomyelin (D18:1/21:0), Vescicular"
-      - metabolites: !!omap
-          - MAM03946c: 1
-          - MAM03946e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11718"
       - name: "Transport of Sphingomyelin (D18:1/22:0), Active Transport"
@@ -235023,21 +233171,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11719"
-      - name: "Transport of Sphingomyelin (D18:1/22:0), Vescicular Transport"
-      - metabolites: !!omap
-          - MAM03948c: 1
-          - MAM03948e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11720"
       - name: "Transport of Sphingomyelin (D18:1/22:1), Active"
@@ -235058,21 +233191,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11721"
-      - name: "Transport of Sphingomyelin (D18:1/22:1), Vescicular"
-      - metabolites: !!omap
-          - MAM03947c: 1
-          - MAM03947e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11722"
       - name: "Transport of Sphingomyelin (D18:1/23:0), Active"
@@ -235093,21 +233211,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11723"
-      - name: "Transport of Sphingomyelin (D18:1/23:0), Vescicular"
-      - metabolites: !!omap
-          - MAM03949c: 1
-          - MAM03949e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11724"
       - name: "Transport of Sphingomyelin (D18:0/24:0), Active Transport"
@@ -235128,21 +233231,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11725"
-      - name: "Transport of Sphingomyelin (D18:0/24:0), Vescicular Transport"
-      - metabolites: !!omap
-          - MAM03950c: 1
-          - MAM03950e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11726"
       - name: "Transport of Sphingomyelin (D18:0/25:0), Active Transport"
@@ -235163,28 +233251,13 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11727"
-      - name: "Transport of Sphingomyelin (D18:0/25:0), Vescicular Transport"
-      - metabolites: !!omap
-          - MAM03951c: 1
-          - MAM03951e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:11581500;PMID:10856719"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11728"
       - name: "Transport of 2-Hydroxy-Isocaproate, Extracellular, Uptake"
       - metabolites: !!omap
           - MAM03187c: 1
           - MAM03187e: -1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -235193,21 +233266,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11729"
-      - name: "Transport of 2-Hydroxy-Isocaproate, Extracellular, Secretion"
-      - metabolites: !!omap
-          - MAM03187c: -1
-          - MAM03187e: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11730"
       - name: "Exchange of 2-Hydroxy-Isocaproate"
@@ -239139,7 +237197,7 @@
       - metabolites: !!omap
           - MAM01351c: -1
           - MAM01351e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -239162,28 +237220,13 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11988"
-      - name: "Transport of Apo B, Extracellular"
-      - metabolites: !!omap
-          - MAM01351c: 1
-          - MAM01351e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11989"
       - name: "Transport of Apo C1, Extracellular"
       - metabolites: !!omap
           - MAM01353c: -1
           - MAM01353e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -239206,28 +237249,13 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11991"
-      - name: "Transport of Apo C1, Extracellular"
-      - metabolites: !!omap
-          - MAM01353c: 1
-          - MAM01353e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11992"
       - name: "Transport of Apo C2, Extracellular"
       - metabolites: !!omap
           - MAM01354c: -1
           - MAM01354e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -239250,28 +237278,13 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11994"
-      - name: "Transport of Apo C2, Extracellular"
-      - metabolites: !!omap
-          - MAM01354c: 1
-          - MAM01354e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11995"
       - name: "Transport of Apo C3, Extracellular"
       - metabolites: !!omap
           - MAM01355c: -1
           - MAM01355e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -239294,28 +237307,13 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11997"
-      - name: "Transport of Apo C3, Extracellular"
-      - metabolites: !!omap
-          - MAM01355c: 1
-          - MAM01355e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11998"
       - name: "Transport of Apo E, Extracellular"
       - metabolites: !!omap
           - MAM01359c: -1
           - MAM01359e: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
@@ -239338,21 +237336,6 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR12000"
-      - name: "Transport of Apo E, Extracellular"
-      - metabolites: !!omap
-          - MAM01359c: 1
-          - MAM01359e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR12001"
       - name: "Dopamine 4-O-Sulfotransferase"
@@ -241364,13 +239347,13 @@
       - id: "MAR12146"
       - name: "3-dehydro-chenodehydroxycholic acid formation"
       - metabolites: !!omap
+          - MAM01435c: -1
           - MAM02039c: -1
           - MAM02040c: 2
           - MAM02554c: 1
           - MAM02555c: -1
           - MAM02630c: -1
           - MAM03206c: 1
-          - MAM03318c: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Cyp9b2 or Cyp9c1 or Cyp9f2"
@@ -241872,9 +239855,9 @@
       - id: "MAR12174"
       - name: "UDP-Glucuronosyltransferase (UGT) cytosolic (chenodeoxycholic acid)"
       - metabolites: !!omap
+          - MAM01435c: -1
           - MAM03106c: 1
           - MAM03109c: -1
-          - MAM03318c: -1
           - MAM03508c: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -241889,9 +239872,9 @@
       - id: "MAR12175"
       - name: "UDP-Glucuronosyltransferase (UGT) (chenodeoxycholic acid)"
       - metabolites: !!omap
+          - MAM01435r: -1
           - MAM03106r: 1
           - MAM03109r: -1
-          - MAM03318r: -1
           - MAM03508r: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -241941,9 +239924,9 @@
       - id: "MAR12178"
       - name: "UDP-Glucuronosyltransferase (UGT) cytosolic (chenodeoxycholic acid)"
       - metabolites: !!omap
+          - MAM01435c: -1
           - MAM03106c: 1
           - MAM03109c: -1
-          - MAM03318c: -1
           - MAM03509c: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -241958,9 +239941,9 @@
       - id: "MAR12179"
       - name: "UDP-Glucuronosyltransferase (UGT) ER (chenodeoxycholic acid)"
       - metabolites: !!omap
+          - MAM01435r: -1
           - MAM03106r: 1
           - MAM03109r: -1
-          - MAM03318r: -1
           - MAM03509r: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -242027,12 +240010,12 @@
       - id: "MAR12183"
       - name: "Chenodeoxycholic acid 6alpha-hydroxylase"
       - metabolites: !!omap
+          - MAM01435c: -1
           - MAM02039c: -1
           - MAM02040c: 1
           - MAM02554c: 1
           - MAM02555c: -1
           - MAM02630c: -1
-          - MAM03318c: -1
           - MAM03685c: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -245214,12 +243197,12 @@
       - metabolites: !!omap
           - MAM01261x: 2
           - MAM01597x: -2
+          - MAM01802x: -1
+          - MAM01803x: 2
           - MAM02039x: 2
           - MAM02040x: -2
-          - MAM02041x: 2
           - MAM02552x: -2
           - MAM02553x: 2
-          - MAM02630x: -1
           - MAM03236x: -1
           - MAM03238x: 1
       - lower_bound: 0
@@ -252208,14 +250191,14 @@
       - metabolites: !!omap
           - MAM01261x: 4
           - MAM01597x: -4
+          - MAM01802x: -2
+          - MAM01803x: 2
           - MAM02039x: 3
           - MAM02040x: -2
-          - MAM02041x: 2
           - MAM02552x: -4
           - MAM02553x: 4
           - MAM02554x: 1
           - MAM02555x: -1
-          - MAM02630x: -2
           - MAM03580x: -1
           - MAM03893x: 1
       - lower_bound: 0
@@ -256095,20 +254078,6 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR13064"
-      - name: "EX_M01268[e]"
-      - metabolites: !!omap
-          - MAM01268e: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Exchange/demand reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR13065"
       - name: "EX_HC02080[e]"
@@ -256395,20 +254364,6 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR10025"
-      - name: "Exchange of 20-hydroxy-arachidonate"
-      - metabolites: !!omap
-          - MAM00591e: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Exchange/demand reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR10026"
       - name: "Exchange of chenodiol"
@@ -257498,10 +255453,9 @@
           - MAM10014c: -0.2212
           - MAM10015c: -0.4835
       - lower_bound: 0
-      - upper_bound: 1000
+      - upper_bound: 0
       - gene_reaction_rule: ""
       - rxnNotes: ""
-      - objective_coefficient: 1
       - eccodes: ""
       - references: ""
       - subsystem:
@@ -258677,24 +256631,6 @@
       - subsystem:
           - "Retinol metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR20002"
-      - name: "MAR20002"
-      - metabolites: !!omap
-          - MAM02039c: 1
-          - MAM02552c: -1
-          - MAM02553c: 1
-          - MAM02832c: 1
-          - MAM02834c: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Fdh"
-      - rxnNotes: ""
-      - eccodes: "1.1.1.105"
-      - references: ""
-      - subsystem:
-          - "Retinol metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR20003"
       - name: "MAR20003"
@@ -258878,23 +256814,6 @@
       - subsystem:
           - "octane oxidation"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR20020"
-      - name: "MAR20020"
-      - metabolites: !!omap
-          - MAM01965r: 1
-          - MAM01968r: -1
-          - MAM02040r: -1
-          - MAM02751r: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "G6P"
-      - rxnNotes: ""
-      - eccodes: "3.1.3.9; 3.1.3.58"
-      - references: ""
-      - subsystem:
-          - "Starch and sucrose metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR20033"
       - name: "MAR20033"
@@ -259467,22 +257386,6 @@
       - subsystem:
           - "Insect hormone biosynthesis"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR20066"
-      - name: "MAR20066"
-      - metabolites: !!omap
-          - MAM02040x: 2
-          - MAM02041x: -2
-          - MAM02630x: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Cat"
-      - rxnNotes: ""
-      - eccodes: "1.11.1.6; 1.11.1.21"
-      - references: ""
-      - subsystem:
-          - "Glyoxylate and dicarboxylate metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR20069"
       - name: "MAR20069"
@@ -259648,7 +257551,7 @@
           - MAM20077n: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG33054"
+      - gene_reaction_rule: "Targ1"
       - rxnNotes: ""
       - eccodes: "3.1.1.106"
       - references: ""
@@ -259666,7 +257569,7 @@
           - MAM20063n: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG33054"
+      - gene_reaction_rule: "Targ1"
       - rxnNotes: ""
       - eccodes: ""
       - references: ""
@@ -259826,6 +257729,57 @@
       - subsystem:
           - "Miscellaneous"
       - confidence_score: 0
+    - !!omap
+      - id: "MAR20112"
+      - name: "MAR20112"
+      - metabolites: !!omap
+          - MAM01285m: 1
+          - MAM01357m: -1
+          - MAM01371m: -1
+          - MAM02039m: 1
+          - MAM02046m: -1
+          - MAM02751m: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "ACC"
+      - rxnNotes: ""
+      - eccodes: "6.4.1.2"
+      - references: "PMID:10677481;PMID:16721829;PMID:17126822;PMID:235695;PMID:24055;PMID:6116153;PMID:6116159;PMID:6116163;PMID:6138355;PMID:7732023;PMID:9099716"
+      - subsystem:
+          - "Fatty acid biosynthesis (even-chain)"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20113"
+      - name: "MAR20113"
+      - metabolites: !!omap
+          - MAM00185c: -1
+          - MAM00185m: 1
+      - lower_bound: -1000
+      - upper_bound: 1000
+      - gene_reaction_rule: ""
+      - rxnNotes: ""
+      - eccodes: ""
+      - references: ""
+      - subsystem:
+          - "Transport reactions"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20114"
+      - name: "MAR20014"
+      - metabolites: !!omap
+          - MAM01802x: 1
+          - MAM01803x: -1
+          - MAM02041x: 1
+          - MAM02630x: -1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "ACOX1 or Acox3 or Acox57D-d or CG8032 or Daao1 or Nos or ry"
+      - rxnNotes: ""
+      - eccodes: ""
+      - references: "PMID:30378035"
+      - subsystem:
+          - "Miscellaneous"
+      - confidence_score: 0
     - !!omap
       - id: "MAR15001"
       - name: ""
@@ -260370,53 +258324,59 @@
           - "Glutathione metabolism"
       - confidence_score: 2
     - !!omap
-      - id: "MAR00113"
-      - name: "C-3 Sterol Dehydrogenase (4-Methylzymosterol)"
+      - id: "MAR03931"
+      - name: "NADPH:oxidized-thioredoxin oxidoreductase"
       - metabolites: !!omap
-          - MAM00809r: 1
-          - MAM00953r: -1
-          - MAM01596r: 1
-          - MAM02039r: 1
-          - MAM02554r: -1
-          - MAM02555r: 1
+          - MAM02039c: -1
+          - MAM02554c: 1
+          - MAM02555c: -1
+          - MAM02666c: -1
+          - MAM02990c: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: "reaction added by gap filling"
-      - eccodes: ""
-      - references: "PMID:10710235;PMID:14506130"
+      - eccodes: "1.8.1.9"
+      - references: "PMID:10462449;PMID:11060283;PMID:15110392"
       - subsystem:
-          - "Cholesterol metabolism"
+          - "Pyrimidine metabolism"
       - confidence_score: 0
     - !!omap
-      - id: "MAR00222"
-      - name: "24-Dehydrocholesterol Reductase [Precursor]"
+      - id: "MAR01557"
+      - name: "lathosterol,ferrocytochrome b5:oxygen oxidoreductase 5,6-dehydrogenating"
       - metabolites: !!omap
-          - MAM01450r: 1
-          - MAM01675r: -1
-          - MAM01802r: 1
-          - MAM01803r: -1
+          - MAM02039c: -1
+          - MAM02040c: 2
+          - MAM02343c: -1
+          - MAM02552c: 1
+          - MAM02553c: -1
+          - MAM02630c: -1
+          - MAM02805c: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: "reaction added by gap filling"
-      - eccodes: "2.3.1.42"
-      - references: "PMID:17984220;PMID:19520779;PMID:19520780"
+      - eccodes: "1.14.21.6"
+      - references: "PMID:11731337;PMID:7946524"
       - subsystem:
-          - "Cholesterol metabolism"
+          - "Cholesterol biosynthesis 2"
       - confidence_score: 0
     - !!omap
-      - id: "MAR00443"
-      - name: "3-Beta-Hydroxysteroid-Delta (8), Delta (7)-Isomerase"
+      - id: "MAR00114"
+      - name: "C-3 Sterol Dehydrogenase (4-Methylzymosterol)"
       - metabolites: !!omap
-          - MAM01066r: 1
-          - MAM03158r: -1
+          - MAM00809r: 1
+          - MAM00953r: -1
+          - MAM01596r: 1
+          - MAM02039r: 1
+          - MAM02552r: -1
+          - MAM02553r: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: "reaction added by gap filling"
-      - eccodes: "5.3.3.5"
-      - references: "PMID:10391219"
+      - eccodes: ""
+      - references: "PMID:12829805"
       - subsystem:
           - "Cholesterol metabolism"
       - confidence_score: 0
@@ -260435,26 +258395,6 @@
       - subsystem:
           - "Cholesterol metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR01508"
-      - name: "Lathosterol Oxidase"
-      - metabolites: !!omap
-          - MAM01066r: -1
-          - MAM01189r: 1
-          - MAM02039r: -1
-          - MAM02040r: 2
-          - MAM02554r: 1
-          - MAM02555r: -1
-          - MAM02630r: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: "reaction added by gap filling"
-      - eccodes: "1.3.3.2"
-      - references: "PMID:10344195"
-      - subsystem:
-          - "Cholesterol metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR01714"
       - name: "Squalene Epoxidase, Endoplasmic Reticular (NADP)"
@@ -260533,6 +258473,39 @@
       - subsystem:
           - "Cholesterol metabolism"
       - confidence_score: 0
+    - !!omap
+      - id: "MAR02337"
+      - name: "Delta24-Sterol Reductase"
+      - metabolites: !!omap
+          - MAM01449r: 1
+          - MAM02039r: -1
+          - MAM02554r: 1
+          - MAM02555r: -1
+          - MAM03158r: -1
+      - lower_bound: -1000
+      - upper_bound: 1000
+      - gene_reaction_rule: ""
+      - rxnNotes: "reaction added by gap filling"
+      - eccodes: "1.3.1.72"
+      - references: "PMID:12162789;PMID:9291139;PMID:9638657"
+      - subsystem:
+          - "Cholesterol metabolism"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR02339"
+      - name: "5Alpha-Cholest-7-En-3Beta-Ol Delta7-Delta8-Isomerase"
+      - metabolites: !!omap
+          - MAM01449r: 1
+          - MAM02343r: -1
+      - lower_bound: -1000
+      - upper_bound: 1000
+      - gene_reaction_rule: ""
+      - rxnNotes: "reaction added by gap filling"
+      - eccodes: "5.3.3.5"
+      - references: "PMID:10391219;PMID:12133002;PMID:4475632;PMID:5810070"
+      - subsystem:
+          - "Cholesterol metabolism"
+      - confidence_score: 0
     - !!omap
       - id: "MAR05151"
       - name: ""
@@ -260593,20 +258566,19 @@
           - "Protein assembly"
       - confidence_score: 0
     - !!omap
-      - id: "MAR04497"
-      - name: "3-hydroxypropanoate:NAD+ oxidoreductase"
+      - id: "MAR04106"
+      - name: "malonyl-CoA carboxy-lyase (acetyl-CoA-forming)"
       - metabolites: !!omap
-          - MAM00900m: 1
-          - MAM02039m: 1
-          - MAM02142m: -1
-          - MAM02552m: -1
-          - MAM02553m: 1
+          - MAM01261m: 1
+          - MAM01596m: 1
+          - MAM02039m: -1
+          - MAM02444m: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: "reaction added by gap filling"
-      - eccodes: "1.1.1.59"
-      - references: "PMID:13672942"
+      - eccodes: "4.1.1.9"
+      - references: "PMID:101148;PMID:10455107;PMID:15003260;PMID:4180063;PMID:4731972;PMID:5578610;PMID:9869665"
       - subsystem:
           - "Propanoate metabolism"
       - confidence_score: 0
@@ -260625,6 +258597,23 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
+    - !!omap
+      - id: "MAR04485"
+      - name: "thymidine:phosphate deoxy-alpha-D-ribosyltransferase"
+      - metabolites: !!omap
+          - MAM00639c: -1
+          - MAM02751c: 1
+          - MAM02996c: 1
+          - MAM02997c: -1
+      - lower_bound: -1000
+      - upper_bound: 1000
+      - gene_reaction_rule: ""
+      - rxnNotes: "reaction added by gap filling"
+      - eccodes: "2.4.2.1;2.4.2.4"
+      - references: "PMID:15262124;PMID:15990964"
+      - subsystem:
+          - "Pyrimidine metabolism"
+      - confidence_score: 0
     - !!omap
       - id: "MAR06981"
       - name: "4-Trimethylammoniobutanal:NAD+ 1-oxidoreductase"
@@ -260664,6 +258653,26 @@
       - subsystem:
           - "Fatty acid desaturation (even-chain)"
       - confidence_score: 0
+    - !!omap
+      - id: "MAR02472"
+      - name: ""
+      - metabolites: !!omap
+          - MAM00108c: 1
+          - MAM02039c: -1
+          - MAM02040c: 2
+          - MAM02390c: -1
+          - MAM02554c: 1
+          - MAM02555c: -1
+          - MAM02630c: -1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: ""
+      - rxnNotes: "reaction added by gap filling"
+      - eccodes: "1.14.19.-"
+      - references: ""
+      - subsystem:
+          - "Omega-3 fatty acid metabolism"
+      - confidence_score: 0
     - !!omap
       - id: "MAR02505"
       - name: ""
@@ -261171,36 +259180,16 @@
           - "Transport reactions"
       - confidence_score: 0
     - !!omap
-      - id: "MAR00145"
-      - name: "Fatty Acyl Coenzyme A Desaturase (N-C18:2CoA -> N-C18:3CoA)"
-      - metabolites: !!omap
-          - MAM00108c: 1
-          - MAM02039c: -1
-          - MAM02040c: 2
-          - MAM02390c: -1
-          - MAM02552c: 1
-          - MAM02553c: -1
-          - MAM02630c: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: "reaction added by gap filling"
-      - eccodes: "1.14.19.1"
-      - references: ""
-      - subsystem:
-          - "Fatty acid biosynthesis"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR00151"
+      - id: "MAR00149"
       - name: "Fatty Acyl Coenzyme A Desaturase (N-C18:1CoA -> N-C18:2CoA)"
       - metabolites: !!omap
-          - MAM00057c: -1
           - MAM00106c: 1
           - MAM02039c: -1
           - MAM02040c: 2
           - MAM02552c: 1
           - MAM02553c: -1
           - MAM02630c: -1
+          - MAM02647c: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -261343,12 +259332,6 @@
     - !!omap
       - id: "Acsl"
       - name: "Acsl"
-    - !!omap
-      - id: "AdSL"
-      - name: "AdSL"
-    - !!omap
-      - id: "AdSS"
-      - name: "AdSS"
     - !!omap
       - id: "Adgf-A"
       - name: "Adgf-A"
@@ -261364,6 +259347,12 @@
     - !!omap
       - id: "Adk2"
       - name: "Adk2"
+    - !!omap
+      - id: "Adsl"
+      - name: "Adsl"
+    - !!omap
+      - id: "Adss"
+      - name: "Adss"
     - !!omap
       - id: "Ae2"
       - name: "Ae2"
@@ -261508,9 +259497,6 @@
     - !!omap
       - id: "Argl"
       - name: "Argl"
-    - !!omap
-      - id: "Art4"
-      - name: "Art4"
     - !!omap
       - id: "AsnRS"
       - name: "AsnRS"
@@ -261550,6 +259536,12 @@
     - !!omap
       - id: "Bcat"
       - name: "Bcat"
+    - !!omap
+      - id: "BckdhA"
+      - name: "BckdhA"
+    - !!omap
+      - id: "BckdhB"
+      - name: "BckdhB"
     - !!omap
       - id: "Bmcp"
       - name: "Bmcp"
@@ -261631,9 +259623,6 @@
     - !!omap
       - id: "CG10467"
       - name: "CG10467"
-    - !!omap
-      - id: "CG10483"
-      - name: "CG10483"
     - !!omap
       - id: "CG10486"
       - name: "CG10486"
@@ -261643,9 +259632,6 @@
     - !!omap
       - id: "CG10602"
       - name: "CG10602"
-    - !!omap
-      - id: "CG10651"
-      - name: "CG10651"
     - !!omap
       - id: "CG10657"
       - name: "CG10657"
@@ -261961,9 +259947,6 @@
     - !!omap
       - id: "CG1764"
       - name: "CG1764"
-    - !!omap
-      - id: "CG17691"
-      - name: "CG17691"
     - !!omap
       - id: "CG17717"
       - name: "CG17717"
@@ -262036,6 +260019,9 @@
     - !!omap
       - id: "CG2528"
       - name: "CG2528"
+    - !!omap
+      - id: "CG2604"
+      - name: "CG2604"
     - !!omap
       - id: "CG2680"
       - name: "CG2680"
@@ -262078,9 +260064,6 @@
     - !!omap
       - id: "CG30345"
       - name: "CG30345"
-    - !!omap
-      - id: "CG30486"
-      - name: "CG30486"
     - !!omap
       - id: "CG30491"
       - name: "CG30491"
@@ -262183,9 +260166,6 @@
     - !!omap
       - id: "CG32847"
       - name: "CG32847"
-    - !!omap
-      - id: "CG33054"
-      - name: "CG33054"
     - !!omap
       - id: "CG33090"
       - name: "CG33090"
@@ -262225,9 +260205,6 @@
     - !!omap
       - id: "CG33934"
       - name: "CG33934"
-    - !!omap
-      - id: "CG34002"
-      - name: "CG34002"
     - !!omap
       - id: "CG34057"
       - name: "CG34057"
@@ -262417,6 +260394,9 @@
     - !!omap
       - id: "CG5162"
       - name: "CG5162"
+    - !!omap
+      - id: "CG5167"
+      - name: "CG5167"
     - !!omap
       - id: "CG5196"
       - name: "CG5196"
@@ -262594,12 +260574,6 @@
     - !!omap
       - id: "CG6847"
       - name: "CG6847"
-    - !!omap
-      - id: "CG6903"
-      - name: "CG6903"
-    - !!omap
-      - id: "CG6910"
-      - name: "CG6910"
     - !!omap
       - id: "CG6951"
       - name: "CG6951"
@@ -262726,9 +260700,6 @@
     - !!omap
       - id: "CG8046"
       - name: "CG8046"
-    - !!omap
-      - id: "CG8072"
-      - name: "CG8072"
     - !!omap
       - id: "CG8112"
       - name: "CG8112"
@@ -262738,9 +260709,6 @@
     - !!omap
       - id: "CG8188"
       - name: "CG8188"
-    - !!omap
-      - id: "CG8199"
-      - name: "CG8199"
     - !!omap
       - id: "CG8314"
       - name: "CG8314"
@@ -262841,8 +260809,8 @@
       - id: "CG9550"
       - name: "CG9550"
     - !!omap
-      - id: "CG9593"
-      - name: "CG9593"
+      - id: "CG9577"
+      - name: "CG9577"
     - !!omap
       - id: "CG9701"
       - name: "CG9701"
@@ -263236,9 +261204,6 @@
     - !!omap
       - id: "Eaat2"
       - name: "Eaat2"
-    - !!omap
-      - id: "Ech1"
-      - name: "Ech1"
     - !!omap
       - id: "Echs1"
       - name: "Echs1"
@@ -263263,9 +261228,6 @@
     - !!omap
       - id: "Egm"
       - name: "Egm"
-    - !!omap
-      - id: "Eip75B"
-      - name: "Eip75B"
     - !!omap
       - id: "Elo68α"
       - name: "Elo68α"
@@ -263509,21 +261471,21 @@
     - !!omap
       - id: "Glut1"
       - name: "Glut1"
-    - !!omap
-      - id: "GlyP"
-      - name: "GlyP"
     - !!omap
       - id: "GlyRS"
       - name: "GlyRS"
-    - !!omap
-      - id: "GlyS"
-      - name: "GlyS"
     - !!omap
       - id: "GlyT"
       - name: "GlyT"
     - !!omap
       - id: "Glyat"
       - name: "Glyat"
+    - !!omap
+      - id: "Glyp"
+      - name: "Glyp"
+    - !!omap
+      - id: "Glys"
+      - name: "Glys"
     - !!omap
       - id: "Gmd"
       - name: "Gmd"
@@ -263611,9 +261573,6 @@
     - !!omap
       - id: "Gyg"
       - name: "Gyg"
-    - !!omap
-      - id: "HDAC3"
-      - name: "HDAC3"
     - !!omap
       - id: "HERC2"
       - name: "HERC2"
@@ -263665,6 +261624,9 @@
     - !!omap
       - id: "Hex-t2"
       - name: "Hex-t2"
+    - !!omap
+      - id: "Hgsnat"
+      - name: "Hgsnat"
     - !!omap
       - id: "Hibch"
       - name: "Hibch"
@@ -263701,9 +261663,6 @@
     - !!omap
       - id: "Hpd"
       - name: "Hpd"
-    - !!omap
-      - id: "Hr3"
-      - name: "Hr3"
     - !!omap
       - id: "Hs2st"
       - name: "Hs2st"
@@ -263752,6 +261711,9 @@
     - !!omap
       - id: "Idua"
       - name: "Idua"
+    - !!omap
+      - id: "Ih"
+      - name: "Ih"
     - !!omap
       - id: "IleRS"
       - name: "IleRS"
@@ -263977,6 +261939,9 @@
     - !!omap
       - id: "Mgtor"
       - name: "Mgtor"
+    - !!omap
+      - id: "Miox"
+      - name: "Miox"
     - !!omap
       - id: "Mipp2"
       - name: "Mipp2"
@@ -264031,9 +261996,6 @@
     - !!omap
       - id: "Mtmr6"
       - name: "Mtmr6"
-    - !!omap
-      - id: "Mtp"
-      - name: "Mtp"
     - !!omap
       - id: "Mtpα"
       - name: "Mtpα"
@@ -264226,9 +262188,6 @@
     - !!omap
       - id: "Nckx30C"
       - name: "Nckx30C"
-    - !!omap
-      - id: "Ncoa6"
-      - name: "Ncoa6"
     - !!omap
       - id: "Ndae1"
       - name: "Ndae1"
@@ -264538,6 +262497,9 @@
     - !!omap
       - id: "PTPMT1"
       - name: "PTPMT1"
+    - !!omap
+      - id: "PXo"
+      - name: "PXo"
     - !!omap
       - id: "Paf-AHα"
       - name: "Paf-AHα"
@@ -264551,8 +262513,8 @@
       - id: "Papss"
       - name: "Papss"
     - !!omap
-      - id: "Parp"
-      - name: "Parp"
+      - id: "Parp1"
+      - name: "Parp1"
     - !!omap
       - id: "Parp16"
       - name: "Parp16"
@@ -264619,9 +262581,6 @@
     - !!omap
       - id: "Pepck2"
       - name: "Pepck2"
-    - !!omap
-      - id: "Pex11ab"
-      - name: "Pex11ab"
     - !!omap
       - id: "Pfas"
       - name: "Pfas"
@@ -264706,9 +262665,6 @@
     - !!omap
       - id: "Pisd"
       - name: "Pisd"
-    - !!omap
-      - id: "Pka-C1"
-      - name: "Pka-C1"
     - !!omap
       - id: "Plc21C"
       - name: "Plc21C"
@@ -264850,9 +262806,6 @@
     - !!omap
       - id: "PolrMT"
       - name: "PolrMT"
-    - !!omap
-      - id: "Pp1-87B"
-      - name: "Pp1-87B"
     - !!omap
       - id: "Ppat-Dpck"
       - name: "Ppat-Dpck"
@@ -264943,9 +262896,6 @@
     - !!omap
       - id: "Rfk"
       - name: "Rfk"
-    - !!omap
-      - id: "Rgl"
-      - name: "Rgl"
     - !!omap
       - id: "RhoGAP92B"
       - name: "RhoGAP92B"
@@ -265000,9 +262950,6 @@
     - !!omap
       - id: "SPoCk"
       - name: "SPoCk"
-    - !!omap
-      - id: "SREBP"
-      - name: "SREBP"
     - !!omap
       - id: "STUB1"
       - name: "STUB1"
@@ -265024,12 +262971,6 @@
     - !!omap
       - id: "Sc2"
       - name: "Sc2"
-    - !!omap
-      - id: "Sccpdh1"
-      - name: "Sccpdh1"
-    - !!omap
-      - id: "Sccpdh2"
-      - name: "Sccpdh2"
     - !!omap
       - id: "Sce"
       - name: "Sce"
@@ -265093,9 +263034,6 @@
     - !!omap
       - id: "SiaT"
       - name: "SiaT"
-    - !!omap
-      - id: "Sin3A"
-      - name: "Sin3A"
     - !!omap
       - id: "Sirt1"
       - name: "Sirt1"
@@ -265120,9 +263058,6 @@
     - !!omap
       - id: "Sln"
       - name: "Sln"
-    - !!omap
-      - id: "Smr"
-      - name: "Smr"
     - !!omap
       - id: "Sms"
       - name: "Sms"
@@ -265168,15 +263103,6 @@
     - !!omap
       - id: "Spn28Dc"
       - name: "Spn28Dc"
-    - !!omap
-      - id: "Spn77Bb"
-      - name: "Spn77Bb"
-    - !!omap
-      - id: "Spn77Bc"
-      - name: "Spn77Bc"
-    - !!omap
-      - id: "Spn85F"
-      - name: "Spn85F"
     - !!omap
       - id: "Sps1"
       - name: "Sps1"
@@ -265240,6 +263166,9 @@
     - !!omap
       - id: "Taldo"
       - name: "Taldo"
+    - !!omap
+      - id: "Targ1"
+      - name: "Targ1"
     - !!omap
       - id: "Tat"
       - name: "Tat"
@@ -265252,9 +263181,6 @@
     - !!omap
       - id: "Tg"
       - name: "Tg"
-    - !!omap
-      - id: "Tgs1"
-      - name: "Tgs1"
     - !!omap
       - id: "Tgt"
       - name: "Tgt"
@@ -265316,8 +263242,8 @@
       - id: "TrpRS"
       - name: "TrpRS"
     - !!omap
-      - id: "Trx-2"
-      - name: "Trx-2"
+      - id: "Trx2"
+      - name: "Trx2"
     - !!omap
       - id: "Trxr1"
       - name: "Trxr1"
@@ -265801,9 +263727,6 @@
     - !!omap
       - id: "eas"
       - name: "eas"
-    - !!omap
-      - id: "ebi"
-      - name: "ebi"
     - !!omap
       - id: "ebo"
       - name: "ebo"
@@ -265849,9 +263772,6 @@
     - !!omap
       - id: "fh"
       - name: "fh"
-    - !!omap
-      - id: "flw"
-      - name: "flw"
     - !!omap
       - id: "foi"
       - name: "foi"
@@ -266062,6 +263982,9 @@
     - !!omap
       - id: "nSMase"
       - name: "nSMase"
+    - !!omap
+      - id: "na"
+      - name: "na"
     - !!omap
       - id: "nac"
       - name: "nac"
@@ -266116,6 +264039,9 @@
     - !!omap
       - id: "p23"
       - name: "p23"
+    - !!omap
+      - id: "para"
+      - name: "para"
     - !!omap
       - id: "park"
       - name: "park"
@@ -266143,6 +264069,12 @@
     - !!omap
       - id: "por"
       - name: "por"
+    - !!omap
+      - id: "ppk11"
+      - name: "ppk11"
+    - !!omap
+      - id: "ppk22"
+      - name: "ppk22"
     - !!omap
       - id: "ppl"
       - name: "ppl"
@@ -266203,9 +264135,6 @@
     - !!omap
       - id: "sbm"
       - name: "sbm"
-    - !!omap
-      - id: "sca"
-      - name: "sca"
     - !!omap
       - id: "schlank"
       - name: "schlank"
@@ -266362,9 +264291,6 @@
     - !!omap
       - id: "upSET"
       - name: "upSET"
-    - !!omap
-      - id: "usp"
-      - name: "usp"
     - !!omap
       - id: "v"
       - name: "v"
diff --git a/model/dependencies.txt b/model/dependencies.txt
index aba56d2..0d92e48 100644
--- a/model/dependencies.txt
+++ b/model/dependencies.txt
@@ -2,4 +2,4 @@ MATLAB	9.10.0.1602886 (R2021a)
 libSBML	5.19.0
 RAVEN_toolbox	2.7.6
 COBRA_toolbox	3.4.0
-Human-GEM	1.16.0
+Human-GEM	1.17.0
diff --git a/model/metabolites.tsv b/model/metabolites.tsv
index 9af5a9b..2b7ee1d 100644
--- a/model/metabolites.tsv
+++ b/model/metabolites.tsv
@@ -75,8 +75,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00026m"	""	""	"CE6186"	""	"m00026m"	""	""	""	"MNXM33779"	""	"CE6186"	"m00026m"	"MAM00026"
 "MAM00026x"	""	""	"CE6186"	""	"m00026p"	""	""	""	"MNXM33779"	""	"CE6186"	"m00026p"	"MAM00026"
 "MAM00027x"	""	""	"CE6191"	""	"m00027p"	""	""	""	"MNXM33780"	"53481494"	"CE6191"	"m00027p"	"MAM00027"
-"MAM00028c"	""	"CHEBI:81563"	"CE7090"	""	"m00028c"	""	""	""	"MNXM33782"	"16061126"	"CE7090"	"m00028c"	"MAM00028"
-"MAM00029c"	""	"CHEBI:81563"	"CE7090"	""	"m00029c"	""	""	"LMFA03070025"	"MNXM33782"	"16061126"	"CE7090"	"m00029c"	"MAM00029"
+"MAM00028c"	""	"CHEBI:81563"	"CE7090"	""	"m00028c"	""	""	""	"MNXM33782"	"16061126"	"CE7090"	"m00028c;MAM00029c"	"MAM00028"
 "MAM00030c"	""	"CHEBI:82558"	""	""	"m00030c"	""	"C19559"	""	"MNXM13488"	""	"M00030"	"m00030c"	"MAM00030"
 "MAM00031c"	""	"CHEBI:33995"	""	""	"m00031c"	""	"C14791"	""	"MNXM6499"	""	"M00031"	"m00031c"	"MAM00031"
 "MAM00032c"	"onpthl"	"CHEBI:33998"	""	""	"m00032c"	""	"C14786"	""	"MNXM12425;MNXM3390"	"108063"	"onpthl"	"m00032c"	"MAM00032"
@@ -86,7 +85,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00035c"	"2425dhvitd3"	"CHEBI:28818"	""	""	"m00035c"	""	"C07712"	"LMST03020273"	"MNXM6763"	""	"2425dhvitd3"	"m00035c"	"MAM00035"
 "MAM00035m"	"2425dhvitd3"	"CHEBI:28818"	""	""	"m00035m"	""	"C07712"	"LMST03020273"	"MNXM6763"	""	"2425dhvitd3"	"m00035m"	"MAM00035"
 "MAM00035e"	"2425dhvitd3"	"CHEBI:28818"	""	""	"m00035s"	""	"C07712"	"LMST03020273"	"MNXM6763"	""	"2425dhvitd3"	"m00035s"	"MAM00035"
-"MAM00036m"	""	"CHEBI:52050"	"CE5168"	""	"m00036m"	""	"C05450"	""	"MNXM732;MNXM827"	"46224537"	"HC01459"	"m00036m"	"MAM00036"
 "MAM00036x"	""	"CHEBI:52050"	"CE5168"	""	"m00036p"	""	"C05450"	""	"MNXM732;MNXM827"	"46224537"	"HC01459"	"m00036p"	"MAM00036"
 "MAM00037x"	"thcholoylcoa"	"CHEBI:27403"	""	""	"m00037p"	""	"C05448"	""	"MNXM165175;MNXM3395;MNXM560"	"46224536"	"thcholoylcoa"	"m00037p"	"MAM00037"
 "MAM00038c"	""	""	""	""	"m00038c"	"HC01597"	"C05754"	""	"MNXM28221"	""	"HC01597"	"m00038c"	"MAM00038"
@@ -119,9 +117,9 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00054m"	""	""	""	""	"m00054m"	""	""	""	""	""	"M00054"	"m00054m"	"MAM00054"
 "MAM00055c"	""	""	""	""	"m00055c"	""	""	""	""	""	"M00055"	"m00055c"	"MAM00055"
 "MAM00056m"	""	"CHEBI:76292"	""	""	"m00056m"	""	""	""	"MNXM170116"	""	"M00056"	"m00056m"	"MAM00056"
-"MAM00057c"	"od2coa"	"CHEBI:50570"	""	"HMDB0006529"	"m00057c"	""	"C16218"	"LMFA07050055"	"MNXM954"	"53477850"	"od2coa"	"m00057c"	"MAM00057"
-"MAM00057m"	"od2coa"	"CHEBI:50570"	""	"HMDB0006529"	"m00057m"	""	"C16218"	"LMFA07050055"	"MNXM954"	"53477850"	"od2coa"	"m00057m"	"MAM00057"
-"MAM00057x"	"od2coa"	"CHEBI:50570"	""	"HMDB0006529"	"m00057p"	""	"C16218"	"LMFA07050055"	"MNXM954"	"53477850"	"od2coa"	"m00057p"	"MAM00057"
+"MAM00057c"	"od2coa"	"CHEBI:50570"	""	"HMDB0006529"	"m00057c"	""	"C16218"	"LMFA07050385"	"MNXM954"	"53477850"	"od2coa"	"m00057c"	"MAM00057"
+"MAM00057m"	"od2coa"	"CHEBI:50570"	""	"HMDB0006529"	"m00057m"	""	"C16218"	"LMFA07050385"	"MNXM954"	"53477850"	"od2coa"	"m00057m"	"MAM00057"
+"MAM00057x"	"od2coa"	"CHEBI:50570"	""	"HMDB0006529"	"m00057p"	""	"C16218"	"LMFA07050385"	"MNXM954"	"53477850"	"od2coa"	"m00057p"	"MAM00057"
 "MAM00058c"	""	""	""	""	"m00058c"	"HC01594"	"C05751"	""	"MNXM23766"	""	"HC01594"	"m00058c"	"MAM00058"
 "MAM00059m"	""	"CHEBI:27537"	""	""	"m00059m"	"HC01415"	"C05276"	"LMFA07050024"	"MNXM784"	"46173358"	"HC01415"	"m00059m"	"MAM00059"
 "MAM00059x"	""	"CHEBI:27537"	""	""	"m00059p"	"HC01415"	"C05276"	"LMFA07050024"	"MNXM784"	"46173358"	"HC01415"	"m00059p"	"MAM00059"
@@ -146,7 +144,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00074c"	""	""	"CE4835"	""	"m00074c"	""	""	""	"MNXM145822"	""	"CE4835"	"m00074c"	"MAM00074"
 "MAM00075x"	""	"CHEBI:20067"	"CE5126"	""	"m00075p"	""	""	"LMFA07050065"	"MNXM108213;MNXM35866"	""	"CE5126"	"m00075p"	"MAM00075"
 "MAM00076x"	""	""	"CE5936"	""	"m00076p"	""	""	""	""	""	"CE5936"	"m00076p"	"MAM00076"
-"MAM00078x"	"pristcoa"	"CHEBI:64039"	"CE5125"	""	"m00078p"	""	""	"LMFA07050064"	"MNXM30947"	""	"CE5125"	"m00078p"	"MAM00078"
+"MAM00078x"	"CE5125"	"CHEBI:64039"	"CE5125"	""	"m00078p"	""	""	"LMFA07050064"	"MNXM30947"	""	"CE5125"	"m00078p"	"MAM00078"
 "MAM00079x"	""	""	"CE5941"	""	"m00079p"	""	""	""	"MNXM30996"	"53481417"	"CE5941"	"m00079p"	"MAM00079"
 "MAM00080x"	""	""	"CE5935"	""	"m00080p"	""	""	""	"MNXM30997"	"53481419"	"CE5935"	"m00080p"	"MAM00080"
 "MAM00081m"	""	""	"CE2418"	""	"m00081m"	""	""	""	"MNXM31113"	"53481423"	"CE2418"	"m00081m"	"MAM00081"
@@ -285,9 +283,9 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00129r"	""	""	""	""	"m00129r"	""	""	""	""	""	"M00129"	"m00129r"	"MAM00129"
 "MAM00130c"	"tettet6crn"	""	""	""	"m00130c"	""	""	""	"MNXM9141"	""	"tettet6crn"	"m00130c"	"MAM00130"
 "MAM00130r"	"tettet6crn"	""	""	""	"m00130r"	""	""	""	"MNXM9141"	""	"tettet6crn"	"m00130r"	"MAM00130"
-"MAM00131c"	"tettet6coa"	"CHEBI:63548"	"CE4837"	"HMDB0006516"	"m00131c"	""	"C16171"	"LMFA07050041"	"MNXM1512;MNXM5945"	"53477846"	"tettet6coa"	"m00131c"	"MAM00131"
+"MAM00131c"	"CE4837;tettet6coa"	"CHEBI:63548"	"CE4837"	"HMDB0006516"	"m00131c"	""	"C16171"	"LMFA07050041"	"MNXM1512;MNXM5945;MNXM165171"	"53477846"	"CE4837;tettet6coa"	"CE4837_c;m00131c;MAM03354c"	"MAM00131"
 "MAM00131x"	"tettet6coa"	"CHEBI:63548"	"CE4837"	"HMDB0006516"	"m00131p"	""	"C16171"	"LMFA07050041"	"MNXM1512;MNXM5945"	"53477846"	"tettet6coa"	"m00131p"	"MAM00131"
-"MAM00131r"	"tettet6coa"	"CHEBI:63548"	"CE4837"	"HMDB0006516"	"m00131r"	""	"C16171"	"LMFA07050041"	"MNXM1512;MNXM5945"	"53477846"	"tettet6coa"	"m00131r"	"MAM00131"
+"MAM00131r"	"CE4837;tettet6coa"	"CHEBI:63548"	"CE4837"	"HMDB0006516"	"m00131r"	""	"C16171"	"LMFA07050041"	"MNXM1512;MNXM5945;MNXM165171"	"53477846"	"CE4837;tettet6coa"	"CE4837_r;m00131r;MAM03354r"	"MAM00131"
 "MAM00132c"	"tettet6"	""	""	""	"m00132c"	""	""	"LMFA01030819"	"MNXM12999"	"152972"	"tettet6"	"m00132c"	"MAM00132"
 "MAM00132l"	"tettet6"	""	""	""	"m00132l"	""	""	"LMFA01030819"	"MNXM12999"	"152972"	"tettet6"	"m00132l"	"MAM00132"
 "MAM00132r"	"tettet6"	""	""	""	"m00132r"	""	""	"LMFA01030819"	"MNXM12999"	"152972"	"tettet6"	"m00132r"	"MAM00132"
@@ -508,7 +506,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00269l"	"10fthf7glu"	""	""	""	"m00269l"	""	""	""	"MNXM5422"	""	"10fthf7glu"	"m00269l"	"MAM00269"
 "MAM00269m"	"10fthf7glu"	""	""	""	"m00269m"	""	""	""	"MNXM5422"	""	"10fthf7glu"	"m00269m"	"MAM00269"
 "MAM00269e"	"10fthf7glu"	""	""	""	"m00269s"	""	""	""	"MNXM5422"	""	"10fthf7glu"	"m00269s"	"MAM00269"
-"MAM00270c"	"wharachd"	"CHEBI:34306"	""	""	"m00270c"	""	"C14748"	""	"MNXM22451"	"5283157"	"wharachd"	"m00270c"	"MAM00270"
+"MAM00270c"	"wharachd"	"CHEBI:34306"	""	""	"m00270c;m00591c"	"HC02179"	"C14748"	""	"MNXM22451;MNXM6760"	"5283157"	"wharachd"	"m00270c;m00591c;MAM00591c"	"MAM00270"
 "MAM00270r"	"wharachd"	"CHEBI:34306"	""	""	"m00270r"	""	"C14748"	""	"MNXM22451"	"5283157"	"wharachd"	"m00270r"	"MAM00270"
 "MAM00271c"	""	""	"CE6447"	""	"m00271c"	""	""	""	"MNXM163636"	""	"CE6447"	"m00271c"	"MAM00271"
 "MAM00272c"	""	""	"CE6459"	""	"m00272c"	""	""	""	"MNXM164048"	""	"CE6459"	"m00272c"	"MAM00272"
@@ -850,8 +848,8 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00528c"	"mi34p"	"CHEBI:28858"	""	"HMDB0006235"	"m00528c"	""	"C04063"	""	"MNXM163431;MNXM2768"	"440211"	"mi34p"	"m00528c"	"MAM00528"
 "MAM00529c"	"mi3p__D"	"CHEBI:18169"	""	""	"m00529c"	""	"C04006"	""	"MNXM540"	"440194"	"mi3p_D"	"m00529c"	"MAM00529"
 "MAM00530c"	"mi4p__D"	"CHEBI:18384"	""	""	"m00530c"	""	"C03546"	""	"MNXM2063"	""	"mi4p_D"	"m00530c"	"MAM00530"
-"MAM00531c"	"ppmi1346p"	""	""	""	"m00531c"	""	"C18058"	""	"MNXM34087"	"890"	"ppmi1346p"	"m00531c"	"MAM00531"
-"MAM00531n"	"ppmi1346p"	""	""	""	"m00531n"	""	"C18058"	""	"MNXM34087"	"890"	"ppmi1346p"	"m00531n"	"MAM00531"
+"MAM00531c"	"ppmi1346p"	""	""	""	"m00531c"	""	"C18058"	""	"MNXM34087"	"96024277"	"ppmi1346p"	"m00531c"	"MAM00531"
+"MAM00531n"	"ppmi1346p"	""	""	""	"m00531n"	""	"C18058"	""	"MNXM34087"	"96024277"	"ppmi1346p"	"m00531n"	"MAM00531"
 "MAM00532c"	""	""	""	""	"m00532c"	""	""	"LMGP10060005"	"MNXM116015"	""	"M00532"	"m00532c"	"MAM00532"
 "MAM00533c"	""	""	"CE6504"	""	"m00533c"	""	""	""	"MNXM164037"	""	"CE6504"	"m00533c"	"MAM00533"
 "MAM00534c"	""	""	"CE3481"	""	"m00534c"	""	""	""	"MNXM32836"	"53481443"	"CE3481"	"m00534c"	"MAM00534"
@@ -938,8 +936,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00588r"	""	""	"CE2056"	""	"m00588r"	""	""	""	"MNXM35484"	"53481509"	"CE2056"	"m00588r"	"MAM00588"
 "MAM00589c"	""	""	"CE6451"	""	"m00589c"	""	""	""	"MNXM163661"	""	"CE6451"	"m00589c"	"MAM00589"
 "MAM00590c"	""	""	"CE5815"	""	"m00590c"	""	""	""	"MNXM164163"	""	"CE5815"	"m00590c"	"MAM00590"
-"MAM00591c"	""	"CHEBI:34306"	""	""	"m00591c"	"HC02179"	"C14748"	""	"MNXM6760"	""	""	"m00591c"	"MAM00591"
-"MAM00591e"	""	"CHEBI:34306"	""	""	"m00591s"	"HC02179"	"C14748"	""	"MNXM6760"	""	""	"m00591s"	"MAM00591"
 "MAM00592r"	"20ahchsterol"	"CHEBI:1296"	""	"HMDB0006283"	"m00592r"	""	"C05500"	"LMST01010201"	"MNXM164166;MNXM3824"	"440711"	"20ahchsterol"	"m00592r"	"MAM00592"
 "MAM00593c"	""	""	"CE6467"	""	"m00593c"	""	""	""	"MNXM166019"	""	"CE6467"	"m00593c"	"MAM00593"
 "MAM00594c"	""	""	"CE6466"	""	"m00594c"	""	""	""	"MNXM35491"	"53481510"	"CE6466"	"m00594c"	"MAM00594"
@@ -979,11 +975,9 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00614r"	"dhcholestancoa"	"CHEBI:15494"	""	"HMDB0002159"	"m00614r"	"HC01332"	"C04644"	"LMST01010221"	"MNXM162803;MNXM90923"	"440420"	"dhcholestancoa"	"m00614r"	"MAM00614"
 "MAM00615c"	""	""	""	""	"m00615c"	""	""	""	"MNXM827"	""	"M00615"	"m00615c"	"MAM00615"
 "MAM00615x"	""	""	""	""	"m00615p"	""	""	""	"MNXM827"	""	"M00615"	"m00615p"	"MAM00615"
-"MAM00616m"	"cholcoar"	"CHEBI:37642"	"CE5165"	""	"m00616m"	"HC01348"	"C15613"	"LMST01010218"	"MNXM549;MNXM90922;MNXM91096"	"15942889"	"cholcoar"	"m00616m"	"MAM00616"
 "MAM00616x"	"cholcoar"	"CHEBI:37642"	"CE5165"	""	"m00616p"	"HC01348"	"C15613"	"LMST01010218"	"MNXM549;MNXM90922;MNXM91096"	"15942889"	"cholcoar"	"m00616p"	"MAM00616"
 "MAM00616r"	"cholcoar"	"CHEBI:37642"	"CE5165"	""	"m00616r"	"HC01348"	"C15613"	"LMST01010218"	"MNXM549;MNXM90922;MNXM91096"	"15942889"	"cholcoar"	"m00616r"	"MAM00616"
 "MAM00617x"	""	""	""	""	"m00617p"	""	"C17346"	""	"MNXM5367"	""	"M00617"	"m00617p"	"MAM00617"
-"MAM00618m"	"cholcoas"	"CHEBI:37643"	"CE5166"	""	"m00618m"	""	"C17343"	""	"MNXM1201;MNXM8131"	"15942888"	"CE5166;cholcoas"	"m00618m"	"MAM00618"
 "MAM00618x"	"cholcoas"	"CHEBI:37643"	"CE5166"	""	"m00618p"	""	"C17343"	""	"MNXM1201;MNXM8131"	"15942888"	"CE5166;cholcoas"	"m00618p"	"MAM00618"
 "MAM00619r"	"xol25oh"	""	""	""	"m00619r"	""	""	"LMST01010018"	"MNXM852"	"65094"	"xol25oh"	"m00619r"	"MAM00619"
 "MAM00620c"	"25hvitd2"	""	""	"HMDB0001438"	"m00620c"	""	""	""	"MNXM4976"	"22833566"	"25hvitd2"	"m00620c"	"MAM00620"
@@ -1084,7 +1078,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00681c"	""	""	"CE4830"	""	"m00681c"	""	""	""	"MNXM145987;MNXM163157"	""	"CE4830"	"m00681c"	"MAM00681"
 "MAM00682m"	""	""	"CE4795"	""	"m00682m"	""	""	""	""	""	"CE4795"	"m00682m"	"MAM00682"
 "MAM00682x"	""	""	"CE4795"	""	"m00682p"	""	""	""	""	""	"CE4795"	"m00682p"	"MAM00682"
-"MAM00684c"	""	"CHEBI:1438"	""	"HMDB0001527"	"m00684c"	""	"C08276"	"LMFA01130006"	"MNXM2782"	"563"	"M00684"	"m00684c"	"MAM00684"
+"MAM00684c"	""	"CHEBI:1438"	""	"HMDB0001527"	"m00684c"	""	"C08276"	"LMFA01130006"	"MNXM2782"	"563"	"M00684"	"m00684c;MAM03325c"	"MAM00684"
 "MAM00685x"	""	""	"CE5943"	""	"m00685p"	""	""	""	""	""	"CE5943"	"m00685p"	"MAM00685"
 "MAM00686x"	""	""	"CE5940"	""	"m00686p"	""	""	""	""	""	"CE5940"	"m00686p"	"MAM00686"
 "MAM00687m"	""	""	"CE5968"	""	"m00687m"	""	""	""	"MNXM161244"	""	"CE5968"	"m00687m"	"MAM00687"
@@ -1181,9 +1175,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00745r"	""	"CHEBI:28834"	""	"HMDB0000626"	"m00745r"	""	"C04483"	"LMST04010040"	"MNXM57907"	"222528"	"dchac"	"m00745r"	"MAM00745"
 "MAM00746m"	""	""	""	""	"m00746m"	""	""	"LMST04030155"	"MNXM30747;MNXM36899"	""	"M00746"	"m00746m"	"MAM00746"
 "MAM00747r"	""	""	"CE1274"	""	"m00747r"	""	""	""	"MNXM151029"	""	"CE1274"	"m00747r"	"MAM00747"
-"MAM00748m"	"cholcoaone"	"CHEBI:27379"	"CE5169"	"HMDB0006891"	"m00748m"	"HC01473"	"C05467"	"LMST01010216"	"MNXM162946;MNXM873"	"440690"	"cholcoaone"	"m00748m"	"MAM00748"
-"MAM00748x"	"cholcoaone"	"CHEBI:27379"	"CE5169"	"HMDB0006891"	"m00748p"	"HC01473"	"C05467"	"LMST01010216"	"MNXM162946;MNXM873"	"440690"	"cholcoaone"	"m00748p"	"MAM00748"
-"MAM00749m"	"cholcoads"	"CHEBI:27505"	""	"HMDB0006889"	"m00749m"	"HC01466"	"C05460"	"LMST01010217"	"MNXM162945;MNXM2747"	"5280797"	"cholcoads"	"m00749m"	"MAM00749"
+"MAM00748x"	"cholcoaone"	"CHEBI:27379"	"CE5169"	"HMDB0006891"	"m00748p"	"HC01473"	"C05467"	"LMST01010216"	"MNXM162946;MNXM873"	"440690"	"cholcoaone"	"m00748p;MAM03368x"	"MAM00748"
 "MAM00749x"	"cholcoads"	"CHEBI:27505"	""	"HMDB0006889"	"m00749p"	"HC01466"	"C05460"	"LMST01010217"	"MNXM162945;MNXM2747"	"5280797"	"cholcoads"	"m00749p"	"MAM00749"
 "MAM00750c"	"thcholst"	"CHEBI:48940"	""	""	"m00750c"	"HC00757"	"C01301"	"LMST04030164"	"MNXM162326;MNXM163900;MNXM867;MNXM90392"	"439479"	"thcholst"	"m00750c"	"MAM00750"
 "MAM00750m"	"thcholst"	"CHEBI:48940"	""	""	"m00750m"	"HC00757"	"C01301"	"LMST04030164"	"MNXM162326;MNXM163900;MNXM867;MNXM90392"	"439479"	"thcholst"	"m00750m"	"MAM00750"
@@ -1202,7 +1194,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00758m"	"dhcholestanate"	"CHEBI:48467"	""	"HMDB0000359"	"m00758m"	"HC01313"	"C04554"	"LMST04030066"	"MNXM162671;MNXM688"	"53477686"	"dhcholestanate"	"m00758m"	"MAM00758"
 "MAM00758x"	"dhcholestanate"	"CHEBI:48467"	""	"HMDB0000359"	"m00758p"	"HC01313"	"C04554"	"LMST04030066"	"MNXM162671;MNXM688"	"53477686"	"dhcholestanate"	"m00758p"	"MAM00758"
 "MAM00758r"	"dhcholestanate"	"CHEBI:48467"	""	"HMDB0000359"	"m00758r"	"HC01313"	"C04554"	"LMST04030066"	"MNXM162671;MNXM688"	"53477686"	"dhcholestanate"	"m00758r"	"MAM00758"
-"MAM00759c"	""	""	""	""	"m00759c"	""	"C13712"	"LMST02030130"	"MNXM3494"	""	"M00759"	"m00759c"	"MAM00759"
 "MAM00760c"	""	"CHEBI:58374"	""	""	"m00760c"	""	"C05665"	""	"MNXM43758"	"75"	"bamppald"	"m00760c"	"MAM00760"
 "MAM00761m"	""	""	"CE3038"	""	"m00761m"	""	""	""	"MNXM6853"	"3081084"	"CE3038"	"m00761m"	"MAM00761"
 "MAM00762g"	"cs_hs_linkage"	"G00157"	""	""	"m00762g"	""	"C04903"	""	"MNXM147451"	""	"cs_hs_linkage"	"m00762g"	"MAM00762"
@@ -1236,7 +1227,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00783c"	""	""	""	""	"m00783c"	""	""	""	"MNXM1171"	""	"M00783"	"m00783c"	"MAM00783"
 "MAM00783x"	""	""	""	""	"m00783p"	""	""	""	"MNXM1171"	""	"M00783"	"m00783p"	"MAM00783"
 "MAM00784m"	"3hmp"	"CHEBI:37373"	""	"HMDB0000023"	"m00784m"	"HC00705"	"C06001"	""	"MNXM396"	"440873"	"3hmp"	"m00784m"	"MAM00784"
-"MAM00785m"	"3hibutcoa"	"CHEBI:15481"	""	""	"m00785m"	"HC01223"	"C04047"	""	"MNXM1034;MNXM446"	"45259165"	"HC01223"	"m00785m"	"MAM00785"
+"MAM00785m"	"3hibutcoa"	"CHEBI:15481"	""	""	"m00785m"	"HC01223"	"C04047"	""	"MNXM1034;MNXM446"	"45259165"	"3hibutcoa;HC01223"	"3hibutcoa_m;m00785m;MAM03226m"	"MAM00785"
 "MAM00786c"	"3hxkynam"	""	""	""	"m00786c"	""	"C05636"	""	"MNXM36534"	"440736"	"3hxkynam"	"m00786c"	"MAM00786"
 "MAM00787c"	""	""	"CE2095"	""	"m00787c"	""	""	""	"MNXM163184"	""	"CE2095"	"m00787c"	"MAM00787"
 "MAM00788c"	"hLkynr"	"CHEBI:17380"	""	"HMDB0000732"	"m00788c"	"HC01079"	"C03227"	""	"MNXM576"	"11811"	"hLkynr"	"m00788c"	"MAM00788"
@@ -1384,21 +1375,20 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00890m"	"3ohodcoa"	"CHEBI:50571"	""	"HMDB0006498"	"m00890m"	""	"C16216"	""	"MNXM513"	"22833663"	"3ohodcoa"	"m00890m"	"MAM00890"
 "MAM00890x"	"3ohodcoa"	"CHEBI:50571"	""	"HMDB0006498"	"m00890p"	""	"C16216"	""	"MNXM513"	"22833663"	"3ohodcoa"	"m00890p"	"MAM00890"
 "MAM00891c"	""	""	""	""	"m00891c"	"HC01593"	"C05750"	""	"MNXM28031"	""	"HC01593"	"m00891c"	"MAM00891"
-"MAM00892m"	""	"CHEBI:28264"	""	""	"m00892m"	"HC01406"	"C05267"	"LMFA07050016"	"MNXM706"	"11966162"	"HC01406"	"m00892m"	"MAM00892"
-"MAM00892x"	""	"CHEBI:28264"	""	""	"m00892p"	"HC01406"	"C05267"	"LMFA07050016"	"MNXM706"	"11966162"	"HC01406"	"m00892p"	"MAM00892"
+"MAM00892m"	""	"CHEBI:28264"	""	""	"m00892m"	"HC01406"	"C05267"	"LMFA07050249"	"MNXM706"	"11966162"	"HC01406"	"m00892m"	"MAM00892"
+"MAM00892x"	""	"CHEBI:28264"	""	""	"m00892p"	"HC01406"	"C05267"	"LMFA07050249"	"MNXM706"	"11966162"	"HC01406"	"m00892p"	"MAM00892"
 "MAM00893m"	""	""	"CE5160"	""	"m00893m"	"HC10858"	""	""	"MNXM150997"	""	"HC10858"	"m00893m"	"MAM00893"
 "MAM00893x"	""	""	"CE5160"	""	"m00893p"	"HC10858"	""	""	"MNXM150997"	""	"HC10858"	"m00893p"	"MAM00893"
 "MAM00894m"	""	""	"CE0853"	""	"m00894m"	"HC10853"	""	""	"MNXM166250"	"440601"	"CE0853;HC10853"	"m00894m"	"MAM00894"
 "MAM00894x"	""	""	"CE0853"	""	"m00894p"	"HC10853"	""	""	"MNXM166250"	"440601"	"CE0853;HC10853"	"m00894p"	"MAM00894"
-"MAM00895m"	"3ohdcoa"	"CHEBI:15491"	""	""	"m00895m"	"HC01398"	"C05259"	"LMFA07050016"	"MNXM738"	"169621"	"3ohdcoa"	"m00895m"	"MAM00895"
-"MAM00895x"	"3ohdcoa"	"CHEBI:15491"	""	""	"m00895p"	"HC01398"	"C05259"	"LMFA07050016"	"MNXM738"	"169621"	"3ohdcoa"	"m00895p"	"MAM00895"
+"MAM00895m"	"3ohdcoa"	"CHEBI:15491"	""	""	"m00895m"	"HC01398"	"C05259"	"LMFA07050250"	"MNXM738"	"169621"	"3ohdcoa"	"m00895m"	"MAM00895"
+"MAM00895x"	"3ohdcoa"	"CHEBI:15491"	""	""	"m00895p"	"HC01398"	"C05259"	"LMFA07050250"	"MNXM738"	"169621"	"3ohdcoa"	"m00895p"	"MAM00895"
 "MAM00896c"	""	""	""	""	"m00896c"	""	""	""	""	""	"M00896"	"m00896c"	"MAM00896"
 "MAM00897m"	""	""	""	""	"m00897m"	""	""	""	""	""	"M00897"	"m00897m"	"MAM00897"
 "MAM00898c"	""	""	""	""	"m00898c"	""	""	""	""	""	"M00898"	"m00898c"	"MAM00898"
 "MAM00899m"	""	""	""	""	"m00899m"	""	""	""	"MNXM10118"	""	"M00899"	"m00899m"	"MAM00899"
 "MAM00900m"	"msa"	"CHEBI:17960"	""	""	"m00900m"	"HC00203"	"C00222"	""	"MNXM244"	"868"	"msa"	"m00900m"	"MAM00900"
 "MAM00901c"	""	""	"CE4851"	""	"m00901c"	""	""	""	"MNXM164265"	""	"CE4851"	"m00901c"	"MAM00901"
-"MAM00902c"	""	""	"CE4820"	""	"m00902c"	""	""	""	"MNXM164259"	""	"CE4820"	"m00902c"	"MAM00902"
 "MAM00903c"	""	""	"CE4834"	""	"m00903c"	""	""	""	"MNXM164266"	""	"CE4834"	"m00903c"	"MAM00903"
 "MAM00904c"	""	""	"CE2253"	""	"m00904c"	""	""	""	"MNXM36773"	"25229583"	"CE2253"	"m00904c"	"MAM00904"
 "MAM00904x"	""	""	"CE2253"	""	"m00904p"	""	""	""	"MNXM36773"	"25229583"	"CE2253"	"m00904p"	"MAM00904"
@@ -1435,7 +1425,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00931c"	""	""	""	""	"m00931c"	""	"C19564"	""	"MNXM10159"	""	"M00931"	"m00931c"	"MAM00931"
 "MAM00932c"	""	""	""	""	"m00932c"	""	"C16453"	""	"MNXM5537"	""	"M00932"	"m00932c"	"MAM00932"
 "MAM00932e"	""	""	""	""	"m00932s"	""	"C16453"	""	"MNXM5537"	""	"M00932"	"m00932s"	"MAM00932"
-"MAM00933c"	"dmnoncoa"	""	"CE4805"	""	"m00933c"	""	""	"LMFA07050034"	"MNXM37161"	""	"CE4805"	"m00933c"	"MAM00933"
+"MAM00933c"	"dmnoncoa"	""	"CE4805"	""	"m00933c"	""	""	"LMFA07050034"	"MNXM37161;MNXM6100"	""	"CE4805;dmnoncoa"	"dmnoncoa_c;m00933c;MAM03554c"	"MAM00933"
 "MAM00933m"	"dmnoncoa"	""	"CE4805"	""	"m00933m"	""	""	"LMFA07050034"	"MNXM37161"	""	"CE4805"	"m00933m"	"MAM00933"
 "MAM00933x"	"dmnoncoa"	""	"CE4805"	""	"m00933p"	""	""	"LMFA07050034"	"MNXM37161"	""	"CE4805"	"m00933p"	"MAM00933"
 "MAM00934m"	""	""	"CE4806"	""	"m00934m"	""	""	""	"MNXM468808"	""	"CE4806"	"m00934m"	"MAM00934"
@@ -1652,8 +1642,8 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01087r"	""	""	"CE1273"	"HMDB0002208"	"m01087r"	""	""	"LMST04030177"	"MNXM163691"	"6453659"	"CE1273"	"m01087r"	"MAM01087"
 "MAM01088r"	""	""	"CE1278"	"HMDB0002180"	"m01088r"	""	""	"LMST04030016"	"MNXM164360"	"5284194"	"CE1278"	"m01088r"	"MAM01088"
 "MAM01089r"	""	""	"CE1272"	"HMDB0000524"	"m01089r"	""	""	"LMST04030031"	"MNXM29720"	"53477712"	"CE1272"	"m01089r"	"MAM01089"
-"MAM01090c"	"xoltetrol"	"CHEBI:17278"	""	"HMDB0001231"	"m01090c"	"HC01455"	"C05446"	"LMST04030014"	"MNXM163006"	"193321"	"xoltetrol"	"m01090c"	"MAM01090"
-"MAM01090m"	"xoltetrol"	"CHEBI:17278"	""	"HMDB0001231"	"m01090m"	"HC01455"	"C05446"	"LMST04030014"	"MNXM163006"	"193321"	"xoltetrol"	"m01090m"	"MAM01090"
+"MAM01090c"	"xoltetrol"	"CHEBI:17278"	""	"HMDB0006264"	"m01090c"	"HC01455"	"C05446"	"LMST04030014"	"MNXM163006"	"193321"	"xoltetrol"	"m01090c"	"MAM01090"
+"MAM01090m"	"xoltetrol"	"CHEBI:17278"	""	"HMDB0006264"	"m01090m"	"HC01455"	"C05446"	"LMST04030014"	"MNXM163006"	"193321"	"xoltetrol"	"m01090m"	"MAM01090"
 "MAM01091c"	""	""	"CE4874"	""	"m01091c"	""	""	""	"MNXM163692"	""	"CE4874"	"m01091c"	"MAM01091"
 "MAM01091m"	""	""	"CE4874"	""	"m01091m"	""	""	""	"MNXM163692"	""	"CE4874"	"m01091m"	"MAM01091"
 "MAM01092c"	""	"CHEBI:17278"	"CE0232"	"HMDB0001231"	"m01092c"	""	"C05446"	""	"MNXM162569"	"193321"	"M01092"	"m01092c"	"MAM01092"
@@ -1704,7 +1694,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01122m"	""	""	"CE5342"	""	"m01122m"	""	""	""	"MNXM162806"	""	"CE5342"	"m01122m"	"MAM01122"
 "MAM01122x"	""	""	"CE5342"	""	"m01122p"	""	""	""	"MNXM162806"	""	"CE5342"	"m01122p"	"MAM01122"
 "MAM01122r"	""	""	"CE5342"	""	"m01122r"	""	""	""	"MNXM162806"	""	"CE5342"	"m01122r"	"MAM01122"
-"MAM01123c"	""	""	"CE2084"	""	"m01123c"	""	""	""	"MNXM162741"	""	"CE7097"	"m01123c"	"MAM01123"
+"MAM01123c"	""	""	"CE7097"	""	"m01123c"	""	""	""	"MNXM162741"	""	"CE7097"	"m01123c"	"MAM01123"
 "MAM01124c"	""	""	"CE5178"	""	"m01124c"	""	""	""	"MNXM38280"	"53481526"	"CE5178"	"m01124c"	"MAM01124"
 "MAM01124m"	""	""	"CE5178"	""	"m01124m"	""	""	""	"MNXM38280"	"53481526"	"CE5178"	"m01124m"	"MAM01124"
 "MAM01124x"	""	""	"CE5178"	""	"m01124p"	""	""	""	"MNXM38280"	"53481526"	"CE5178"	"m01124p"	"MAM01124"
@@ -1855,7 +1845,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01227m"	""	""	"CE5719"	""	"m01227m"	""	""	""	"MNXM39477"	""	"CE5719"	"m01227m"	"MAM01227"
 "MAM01228m"	""	""	"CE5847"	""	"m01228m"	""	""	""	"MNXM39478"	""	"CE5847"	"m01228m"	"MAM01228"
 "MAM01229c"	""	""	"CE3136"	""	"m01229c"	""	""	""	"MNXM166718"	""	"CE3136"	"m01229c"	"MAM01229"
-"MAM01230c"	"retinal_cis_9"	""	"CE5575"	""	"m01230c"	""	""	""	"MNXM162775;MNXM2209"	"638015"	"retinal_cis_9"	"m01230c"	"MAM01230"
+"MAM01230c"	"retinal_cis_9"	""	"CE5575"	""	"m01230c"	""	""	""	"MNXM162775;MNXM2209"	"6436082"	"retinal_cis_9"	"m01230c"	"MAM01230"
 "MAM01230r"	"retinal_cis_9"	""	"CE5575"	""	"m01230r"	""	""	""	"MNXM162775;MNXM2209"	"638015"	"retinal_cis_9"	"m01230r"	"MAM01230"
 "MAM01231c"	""	""	"CE1617"	""	"m01231c"	""	""	""	"MNXM10472"	"449171"	"CE1617"	"m01231c"	"MAM01231"
 "MAM01231r"	""	""	"CE1617"	""	"m01231r"	""	""	""	"MNXM10472"	"449171"	"CE1617"	"m01231r"	"MAM01231"
@@ -1932,12 +1922,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01265m"	"prpncoa"	"CHEBI:15513"	""	""	"m01265m"	"HC00579"	"C00894"	""	"MNXM650"	"439340"	"prpncoa"	"m01265m"	"MAM01265"
 "MAM01266c"	""	""	""	""	"m01266c"	"HC01797"	"C10905"	""	"MNXM2964"	""	"HC01797"	"m01266c"	"MAM01266"
 "MAM01267c"	""	""	""	""	"m01267c"	"HC02116"	""	""	"MNXM166880"	""	"HC02116"	"m01267c"	"MAM01267"
-"MAM01268c"	""	""	""	""	"m01268c"	""	""	"PROTEIN"	""	""	"M01268"	"m01268c"	"MAM01268"
-"MAM01268m"	""	""	""	""	"m01268m"	""	""	"PROTEIN"	""	""	"M01268"	"m01268m"	"MAM01268"
-"MAM01268n"	""	""	""	""	"m01268n"	""	""	"PROTEIN"	""	""	"M01268"	"m01268n"	"MAM01268"
-"MAM01268x"	""	""	""	""	"m01268p"	""	""	"PROTEIN"	""	""	"M01268"	"m01268p"	"MAM01268"
-"MAM01268r"	""	""	""	""	"m01268r"	""	""	"PROTEIN"	""	""	"M01268"	"m01268r"	"MAM01268"
-"MAM01268e"	""	""	""	""	"m01268s"	""	""	"PROTEIN"	""	""	"M01268"	"m01268s"	"MAM01268"
 "MAM01269c"	""	""	""	""	"m01269c"	"HC02082"	""	""	""	""	"HC02082"	"m01269c"	"MAM01269"
 "MAM01270c"	""	""	""	""	"m01270c"	"HC02089"	""	""	""	""	"HC02089"	"m01270c"	"MAM01270"
 "MAM01271c"	""	""	""	""	"m01271c"	"HC02044"	""	""	""	""	"HC02044"	"m01271c"	"MAM01271"
@@ -2019,7 +2003,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01311x"	"akgp_hs"	"CHEBI:17197"	""	""	"m01311p"	""	"C03715"	""	"MNXM9595"	""	"akgp_hs"	"m01311p"	"MAM01311"
 "MAM01312c"	""	"CHEBI:30837"	""	"HMDB0001209"	"m01312c"	""	"C00499"	""	"MNXM584"	"203"	"alltt"	"m01312c"	"MAM01312"
 "MAM01313c"	""	"CHEBI:15676"	""	"HMDB0000462"	"m01313c"	""	"C01551"	""	"MNXM612"	"204"	"alltn"	"m01313c"	"MAM01313"
-"MAM01314c"	""	"CHEBI:50169"	"CE2211"	"HMDB0001449"	"m01314c"	""	"C13712"	"LMST02030130"	"MNXM3494"	"92786"	"CE2211"	"m01314c"	"MAM01314"
+"MAM01314c"	""	"CHEBI:50169"	"CE2211"	"HMDB0001449"	"m01314c"	""	"C13712"	"LMST02030130"	"MNXM3494"	"92786"	"CE2211"	"m01314c;MAM00759c"	"MAM01314"
 "MAM01315c"	""	"CHEBI:730073"	"CE0074"	"HMDB0002818"	"m01315c"	""	"C07599"	""	"MNXM15828"	"5781"	"CE0074"	"m01315c"	"MAM01315"
 "MAM01315e"	""	"CHEBI:730073"	"CE0074"	"HMDB0002818"	"m01315s"	""	"C07599"	""	"MNXM15828"	"5781"	"CE0074"	"m01315s"	"MAM01315"
 "MAM01316c"	"decdp"	""	""	""	"m01316c"	""	""	""	"MNXM1721"	""	"decdp"	"m01316c"	"MAM01316"
@@ -2028,7 +2012,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01319c"	""	""	""	""	"m01319c"	""	"C19581"	""	"MNXM10644"	""	"M01319"	"m01319c"	"MAM01319"
 "MAM01320c"	""	""	""	""	"m01320c"	""	"C19580"	""	"MNXM10645"	""	"M01320"	"m01320c"	"MAM01320"
 "MAM01321c"	""	""	"CE5853"	""	"m01321c"	""	""	""	"MNXM15963"	""	"CE5853"	"m01321c"	"MAM01321"
-"MAM01322c"	"gal1p"	"CHEBI:17973"	""	""	"m01322c"	""	"C03384"	""	"MNXM336"	"123912"	"gal1p"	"m01322c"	"MAM01322"
+"MAM01322c"	"gal1p"	"CHEBI:17973"	""	""	"m01322c"	""	"C00446"	""	"MNXM336"	"123912"	"gal1p"	"m01322c"	"MAM01322"
 "MAM01323c"	"m1mpdol__L"	"CHEBI:28067"	""	""	"m01323c"	""	"C05861"	""	"MNXM148043"	""	"m1mpdol_L"	"m01323c"	"MAM01323"
 "MAM01324c"	"acgagbside_hs"	""	""	""	"m01324c"	""	""	""	"MNXM7051"	""	"acgagbside_hs"	"m01324c"	"MAM01324"
 "MAM01324g"	"acgagbside_hs"	""	""	""	"m01324g"	""	""	""	"MNXM7051"	""	"acgagbside_hs"	"m01324g"	"MAM01324"
@@ -2225,6 +2209,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01420c"	"cbp"	"CHEBI:17672"	""	""	"m01420c"	"HC00164"	"C00169"	""	"MNXM138"	"278"	"cbp"	"m01420c"	"MAM01420"
 "MAM01420r"	"cbp"	"CHEBI:17672"	""	""	"m01420r"	"HC00164"	"C00169"	""	"MNXM138"	"278"	"cbp"	"m01420r"	"MAM01420"
 "MAM01422c"	"cbtnCCP"	""	""	""	"m01422c"	""	"C04419"	""	"MNXM5655"	""	""	"m01422c"	"MAM01422"
+"MAM01422m"	"cbtnCCP"	""	""	""	""	""	"C04419"	""	"MNXM5655"	""	""	""	"MAM01422"
 "MAM01423c"	"carn"	"CHEBI:15727"	""	"HMDB0000033"	"m01423c"	"HC00321"	"C00386"	""	"MNXM114412;MNXM1419"	"439224"	"carn"	"m01423c"	"MAM01423"
 "MAM01424c"	"cdp"	"CHEBI:17239"	""	""	"m01424c"	"HC00110"	"C00112"	""	"MNXM220"	"6132"	"cdp"	"m01424c"	"MAM01424"
 "MAM01424m"	"cdp"	"CHEBI:17239"	""	""	"m01424m"	"HC00110"	"C00112"	""	"MNXM220"	"6132"	"cdp"	"m01424m"	"MAM01424"
@@ -2254,9 +2239,9 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01434c"	"dcholcoa"	"CHEBI:28701"	""	"HMDB0006292"	"m01434c"	"HC01426"	"C05337"	""	"MNXM834"	"11953854"	"dcholcoa"	"m01434c"	"MAM01434"
 "MAM01434x"	"dcholcoa"	"CHEBI:28701"	""	"HMDB0006292"	"m01434p"	"HC01426"	"C05337"	""	"MNXM834"	"11953854"	"dcholcoa"	"m01434p"	"MAM01434"
 "MAM01434r"	"dcholcoa"	"CHEBI:28701"	""	"HMDB0006292"	"m01434r"	"HC01426"	"C05337"	""	"MNXM834"	"11953854"	"dcholcoa"	"m01434r"	"MAM01434"
-"MAM01435c"	""	"CHEBI:16755"	""	"HMDB0000518"	"m01435c"	"HC00958"	"C02528"	"LMST04010032"	"MNXM1183"	"10133"	"HC00958"	"m01435c"	"MAM01435"
-"MAM01435r"	""	"CHEBI:16755"	""	"HMDB0000518"	"m01435r"	"HC00958"	"C02528"	"LMST04010032"	"MNXM1183"	"10133"	"HC00958"	"m01435r"	"MAM01435"
-"MAM01435e"	""	"CHEBI:16755"	""	"HMDB0000518"	"m01435s"	"HC00958"	"C02528"	"LMST04010032"	"MNXM1183"	"10133"	"HC00958"	"m01435s"	"MAM01435"
+"MAM01435c"	""	"CHEBI:16755"	""	"HMDB0000518"	"m01435c"	"HC00958"	"C02528"	"LMST04010032"	"MNXM1183"	"10133"	"HC00958"	"m01435c;MAM03318c"	"MAM01435"
+"MAM01435r"	""	"CHEBI:16755"	""	"HMDB0000518"	"m01435r"	"HC00958"	"C02528"	"LMST04010032"	"MNXM1183"	"10133"	"HC00958"	"m01435r;MAM03318r"	"MAM01435"
+"MAM01435e"	"C02528"	"CHEBI:16755"	""	"HMDB0000518"	"m01435s"	"HC00958"	"C02528"	"LMST04010032"	"MNXM1183"	"10133"	"C02528;HC00958"	"C02528_s;m01435s;MAM03318e"	"MAM01435"
 "MAM01436c"	""	"CHEBI:17029"	""	""	"m01436c"	""	"C00461"	""	"MNXM10923;MNXM1271"	""	"M01436"	"m01436c"	"MAM01436"
 "MAM01437c"	""	"CHEBI:17029"	""	""	"m01437c"	""	"C00461"	""	"MNXM1271;MNXM46301"	""	"M01437"	"m01437c"	"MAM01437"
 "MAM01438c"	"chtn"	""	""	""	"m01438c"	"HC02118"	""	""	"MNXM1271"	""	"chtn"	"m01438c"	"MAM01438"
@@ -2415,7 +2400,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01513r"	"chol"	"CHEBI:15354"	""	"HMDB0000097"	"m01513r"	"HC00112"	"C00114"	""	"MNXM90"	"305"	"chol"	"m01513r"	"MAM01513"
 "MAM01513e"	"chol"	"CHEBI:15354"	""	"HMDB0000097"	"m01513s"	"HC00112"	"C00114"	""	"MNXM90"	"305"	"chol"	"m01513s"	"MAM01513"
 "MAM01514c"	"cholcoa"	"CHEBI:15519"	""	"HMDB0001374"	"m01514c"	"HC00844"	"C01794"	""	"MNXM162468;MNXM431"	"439573"	"cholcoa"	"m01514c"	"MAM01514"
-"MAM01514m"	"cholcoa"	"CHEBI:15519"	""	"HMDB0001374"	"m01514m"	"HC00844"	"C01794"	""	"MNXM162468;MNXM431"	"439573"	"cholcoa"	"m01514m"	"MAM01514"
 "MAM01514x"	"cholcoa"	"CHEBI:15519"	""	"HMDB0001374"	"m01514p"	"HC00844"	"C01794"	""	"MNXM162468;MNXM431"	"439573"	"cholcoa"	"m01514p"	"MAM01514"
 "MAM01514r"	"cholcoa"	"CHEBI:15519"	""	"HMDB0001374"	"m01514r"	"HC00844"	"C01794"	""	"MNXM162468;MNXM431"	"439573"	"cholcoa"	"m01514r"	"MAM01514"
 "MAM01515g"	"cs_a_b_pre2"	""	""	""	"m01515g"	""	""	""	"MNXM148157"	""	"cs_a_b_pre2"	"m01515g"	"MAM01515"
@@ -2775,10 +2759,10 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01695c"	"digalsgalside_hs"	""	""	""	"m01695c"	""	"C06127"	""	"MNXM91564"	""	"digalsgalside_hs"	"m01695c"	"MAM01695"
 "MAM01695g"	"digalsgalside_hs"	""	""	""	"m01695g"	""	"C06127"	""	"MNXM91564"	""	"digalsgalside_hs"	"m01695g"	"MAM01695"
 "MAM01695e"	"digalsgalside_hs"	""	""	""	"m01695s"	""	"C06127"	""	"MNXM91564"	""	"digalsgalside_hs"	"m01695s"	"MAM01695"
-"MAM01696c"	"dlnlcg"	"CHEBI:53486"	"CE2516"	"HMDB0002925"	"m01696c"	"HC02100"	"C03242"	"LMFA01030158"	"MNXM147467;MNXM5607"	"5280581"	"dlnlcg"	"m01696c"	"MAM01696"
+"MAM01696c"	"CE2516;dlnlcg"	"CHEBI:53486"	"CE2516"	"HMDB0002925"	"m01696c"	"HC02100"	"C03242"	"LMFA01030158"	"MNXM147467;MNXM5607"	"5280581"	"CE2516;dlnlcg"	"CE2516_c;m01696c;MAM03332c"	"MAM01696"
 "MAM01696l"	"dlnlcg"	"CHEBI:53486"	"CE2516"	"HMDB0002925"	"m01696l"	"HC02100"	"C03242"	"LMFA01030158"	"MNXM147467;MNXM5607"	"5280581"	"dlnlcg"	"m01696l"	"MAM01696"
 "MAM01696r"	"dlnlcg"	"CHEBI:53486"	"CE2516"	"HMDB0002925"	"m01696r"	"HC02100"	"C03242"	"LMFA01030158"	"MNXM147467;MNXM5607"	"5280581"	"dlnlcg"	"m01696r"	"MAM01696"
-"MAM01696e"	"dlnlcg"	"CHEBI:53486"	"CE2516"	"HMDB0002925"	"m01696s"	"HC02100"	"C03242"	"LMFA01030158"	"MNXM147467;MNXM5607"	"5280581"	"dlnlcg"	"m01696s"	"MAM01696"
+"MAM01696e"	"dlnlcg"	"CHEBI:53486"	"CE2516"	"HMDB0002925"	"m01696s"	"HC02100"	"C03242"	"LMFA01030158"	"MNXM147467;MNXM5607"	"5280581"	"CE2516;dlnlcg"	"CE2516_s;m01696s;MAM03332e"	"MAM01696"
 "MAM01697c"	"dlnlcgcoa"	"CHEBI:27979"	""	"HMDB0003947"	"m01697c"	"HC02102"	"C03595"	"LMFA07050011"	"MNXM1536;MNXM5128"	"16061156"	"dlnlcgcoa"	"m01697c"	"MAM01697"
 "MAM01697m"	"dlnlcgcoa"	"CHEBI:27979"	""	"HMDB0003947"	"m01697m"	"HC02102"	"C03595"	"LMFA07050011"	"MNXM1536;MNXM5128"	"16061156"	"dlnlcgcoa"	"m01697m"	"MAM01697"
 "MAM01697r"	"dlnlcgcoa"	"CHEBI:27979"	""	"HMDB0003947"	"m01697r"	"HC02102"	"C03595"	"LMFA07050011"	"MNXM1536;MNXM5128"	"16061156"	"dlnlcgcoa"	"m01697r"	"MAM01697"
@@ -2842,7 +2826,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01727m"	""	""	""	""	"m01727m"	""	""	""	""	""	"M01727"	"m01727m"	"MAM01727"
 "MAM01727r"	""	""	""	""	"m01727r"	""	""	""	""	""	"M01727"	"m01727r"	"MAM01727"
 "MAM01728c"	"ddcaACP"	""	""	""	"m01728c"	"HC01394"	"C05223"	""	"MNXM5723;MNXM89851"	""	"ddcaACP"	"m01728c"	"MAM01728"
-"MAM01729c"	""	""	""	"HMDB0002250"	"m01729c"	""	""	""	"MNXM51468;MNXM588354"	"168381"	"M01729"	"m01729c"	"MAM01729"
+"MAM01729c"	""	""	""	"HMDB0002250"	"m01729c"	""	""	""	"MNXM51468;MNXM588354"	"168381"	"M01729"	"m01729c;MAM03540c"	"MAM01729"
 "MAM01729m"	""	""	""	"HMDB0002250"	"m01729m"	""	""	""	"MNXM51468;MNXM588354"	"168381"	"M01729"	"m01729m"	"MAM01729"
 "MAM01729r"	""	""	""	"HMDB0002250"	"m01729r"	""	""	""	"MNXM51468;MNXM588354"	"168381"	"M01729"	"m01729r"	"MAM01729"
 "MAM01730c"	"dolichol__L"	"CHEBI:16091"	""	""	"m01730c"	""	"C00381"	"LMPR03070004"	"MNXM147098"	""	"dolichol_L"	"m01730c"	"MAM01730"
@@ -2861,7 +2845,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01737c"	"dopasf"	"CHEBI:37946"	""	""	"m01737c"	""	"C13690"	""	"MNXM163796"	"122136"	"dopasf"	"m01737c"	"MAM01737"
 "MAM01737e"	"dopasf"	"CHEBI:37946"	""	""	"m01737s"	""	"C13690"	""	"MNXM163796"	"122136"	"dopasf"	"m01737s"	"MAM01737"
 "MAM01738c"	""	""	"CE5276"	""	"m01738c"	""	""	""	"MNXM5727"	"162602"	"CE5276"	"m01738c"	"MAM01738"
-"MAM01739c"	""	"CHEBI:27404"	"CE4888"	"HMDB0004058"	"m01739c"	""	"C05578"	""	"MNXM163363"	"114683"	"CE4888"	"m01739c"	"MAM01739"
+"MAM01739c"	""	"CHEBI:27404"	"CE4888"	"HMDB0004058"	"m01739c;m03162c"	""	"C05578"	""	"MNXM163363;MNXM2336"	"114683"	"CE4888;M03162"	"m01739c;m03162c;MAM03162c"	"MAM01739"
 "MAM01740c"	"orn__D"	"CHEBI:16176"	""	"HMDB0003374"	"m01740c"	""	"C00515"	""	"MNXM1148"	"71082"	"orn_D"	"m01740c"	"MAM01740"
 "MAM01740x"	"orn__D"	"CHEBI:16176"	""	"HMDB0003374"	"m01740p"	""	"C00515"	""	"MNXM1148"	"71082"	"orn_D"	"m01740p"	"MAM01740"
 "MAM01740e"	"orn__D"	"CHEBI:16176"	""	"HMDB0003374"	"m01740s"	""	"C00515"	""	"MNXM1148"	"71082"	"orn_D"	"m01740s"	"MAM01740"
@@ -2878,7 +2862,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01744e"	"ser__D"	"CHEBI:16523"	""	"HMDB0003406"	"m01744s"	""	"C00740"	""	"MNXM694"	"71077"	"ser_D"	"m01744s"	"MAM01744"
 "MAM01745c"	"tag__D"	"CHEBI:47693"	""	"HMDB0003418"	"m01745c"	""	"C00795"	""	"MNXM92401"	"92092"	"tagat_D"	"m01745c"	"MAM01745"
 "MAM01745e"	"tag__D"	"CHEBI:47693"	""	"HMDB0003418"	"m01745s"	""	"C00795"	""	"MNXM92401"	"92092"	"tagat_D"	"m01745s"	"MAM01745"
-"MAM01746c"	"tag1p__D"	"CHEBI:4251"	""	""	"m01746c"	"HC00664"	"C01097"	""	"MNXM164716;MNXM795"	"439396"	"HC00664"	"m01746c"	"MAM01746"
+"MAM01746c"	"tag6p__D"	"CHEBI:4251"	""	""	"m01746c"	"HC00664"	"C01097"	""	"MNXM164716;MNXM795"	"439396"	"HC00664"	"m01746c"	"MAM01746"
 "MAM01747c"	"dtdp"	"CHEBI:18075"	""	"HMDB0001274"	"m01747c"	"HC00307"	"C00363"	""	"MNXM152"	"164628"	"dtdp"	"m01747c"	"MAM01747"
 "MAM01747m"	"dtdp"	"CHEBI:18075"	""	"HMDB0001274"	"m01747m"	"HC00307"	"C00363"	""	"MNXM152"	"164628"	"dtdp"	"m01747m"	"MAM01747"
 "MAM01747n"	"dtdp"	"CHEBI:18075"	""	"HMDB0001274"	"m01747n"	"HC00307"	"C00363"	""	"MNXM152"	"164628"	"dtdp"	"m01747n"	"MAM01747"
@@ -3029,7 +3013,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01813c"	""	"CHEBI:35366"	""	""	"m01813c"	"HC02065"	"C00162"	""	"MNXM72"	""	"HC02065"	"m01813c"	"MAM01813"
 "MAM01814c"	""	"CHEBI:35366"	""	""	"m01814c"	"HC02064"	"C00162"	""	"MNXM72"	""	"HC02064"	"m01814c"	"MAM01814"
 "MAM01815c"	""	"CHEBI:35366"	""	""	"m01815c"	"HC02063"	"C00162"	""	"MNXM72"	""	"HC02063"	"m01815c"	"MAM01815"
-"MAM01816n"	""	""	""	""	"m01816n"	""	""	"PROTEIN"	""	""	"M01816"	"m01816n"	"MAM01816"
 "MAM01819e"	""	"CHEBI:35366"	""	""	"m01819s"	""	"C00162"	""	"MNXM72"	""	"M01819"	"m01819s"	"MAM01819"
 "MAM01820e"	""	"CHEBI:35366"	""	""	"m01820s"	""	"C00162"	""	"MNXM72"	""	"M01820"	"m01820s"	"MAM01820"
 "MAM01821c"	"fe2"	"CHEBI:29033"	""	"HMDB0000692"	"m01821c"	"HC01846"	"C14818"	""	"MNXM111"	"27284"	"fe2"	"m01821c"	"MAM01821"
@@ -3332,8 +3315,8 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM02007c"	"glx"	"CHEBI:16891"	""	"HMDB0000119"	"m02007c"	""	"C00048"	""	"MNXM69"	"760"	"glx"	"m02007c"	"MAM02007"
 "MAM02007m"	"glx"	"CHEBI:16891"	""	"HMDB0000119"	"m02007m"	""	"C00048"	""	"MNXM69"	"760"	"glx"	"m02007m"	"MAM02007"
 "MAM02007x"	"glx"	"CHEBI:16891"	""	"HMDB0000119"	"m02007p"	""	"C00048"	""	"MNXM69"	"760"	"glx"	"m02007p"	"MAM02007"
-"MAM02008c"	"gm1_hs"	"CHEBI:18216"	""	""	"m02008c"	"HC02161"	"C04911"	"LMSP0601AP00"	"MNXM164818"	""	"HC02161"	"m02008c"	"MAM02008"
-"MAM02008l"	"gm1_hs"	"CHEBI:18216"	""	""	"m02008l"	"HC02161"	"C04911"	"LMSP0601AP00"	"MNXM164818"	""	"HC02161"	"m02008l"	"MAM02008"
+"MAM02008c"	"HC02161"	"CHEBI:18216"	""	""	"m02008c"	"HC02161"	"C04911"	"LMSP0601AP00"	"MNXM164818"	""	"HC02161"	"m02008c"	"MAM02008"
+"MAM02008l"	"HC02161"	"CHEBI:18216"	""	""	"m02008l"	"HC02161"	"C04911"	"LMSP0601AP00"	"MNXM164818"	""	"HC02161"	"m02008l"	"MAM02008"
 "MAM02009g"	"gm1a_hs"	""	""	""	"m02009g"	""	""	""	"MNXM92361"	""	"gm1a_hs"	"m02009g"	"MAM02009"
 "MAM02011c"	"gm2_hs"	"CHEBI:51013"	""	"HMDB0004936"	"m02011c"	"HC02160"	"C04884"	"LMSP0601AM00"	"MNXM164819"	"20057332"	"HC02160"	"m02011c"	"MAM02011"
 "MAM02011g"	"gm2_hs"	"CHEBI:51013"	""	"HMDB0004936"	"m02011g"	"HC02160"	"C04884"	"LMSP0601AM00"	"MNXM164819"	"20057332"	"HC02160"	"m02011g"	"MAM02011"
@@ -3421,7 +3404,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM02041e"	"h2o2"	"CHEBI:16240"	""	"HMDB0003125"	"m02041s"	"HC00036"	"C00027"	""	"MNXM22"	"784"	"h2o2"	"m02041s"	"MAM02041"
 "MAM02042c"	""	"CHEBI:16136"	""	""	"m02042c"	"HC00250"	"C00283"	""	"MNXM162964;MNXM89582"	"402"	"HC00250"	"m02042c"	"MAM02042"
 "MAM02042e"	""	"CHEBI:16136"	""	""	"m02042s"	"HC00250"	"C00283"	""	"MNXM162964;MNXM89582"	"402"	"HC00250"	"m02042s"	"MAM02042"
-"MAM02043c"	""	"CHEBI:16094"	""	""	"m02043c"	"HC01501"	"C00320"	""	"MNXM164836;MNXM323"	"24478"	"HC01501"	"m02043c"	"MAM02043"
+"MAM02043c"	""	"CHEBI:5587"	""	""	"m02043c"	"HC01501"	"C05529"	""	"MNXM164836;MNXM323"	"24478"	"HC01501"	"m02043c"	"MAM02043"
 "MAM02044c"	""	""	""	""	"m02044c"	"HC01939"	""	"PROTEIN"	""	""	"HC01939"	"m02044c"	"MAM02044"
 "MAM02044l"	""	""	""	""	"m02044l"	"HC01939"	""	"PROTEIN"	""	""	"HC01939"	"m02044l"	"MAM02044"
 "MAM02044e"	""	""	""	""	"m02044s"	"HC01939"	""	"PROTEIN"	""	""	"HC01939"	"m02044s"	"MAM02044"
@@ -3832,11 +3815,11 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM02325e"	"3aib"	"CHEBI:33094"	""	"HMDB0002166"	"m02325s"	""	"C03284"	""	"MNXM2053;MNXM786"	"439434"	"3aib"	"m02325s"	"MAM02325"
 "MAM02326e"	""	"CHEBI:16934"	""	""	"m02326s"	"HC00955"	"C02512"	""	"MNXM1014"	"439742"	"HC00955"	"m02326s"	"MAM02326"
 "MAM02327m"	"4hglusa"	"CHEBI:27809"	""	"HMDB0006556"	"m02327m"	""	"C05938"	""	"MNXM2687"	"440851"	"4hglusa"	"m02327m"	"MAM02327"
-"MAM02328c"	"galgluside_hs"	"CHEBI:17950"	""	"HMDB0004866"	"m02328c"	"HC02162"	"C01290"	"LMSP0501AB00"	"MNXM269"	""	"C01290"	"m02328c"	"MAM02328"
-"MAM02328g"	"galgluside_hs"	"CHEBI:17950"	""	"HMDB0004866"	"m02328g"	"HC02162"	"C01290"	"LMSP0501AB00"	"MNXM269"	""	"C01290"	"m02328g"	"MAM02328"
-"MAM02328l"	"galgluside_hs"	"CHEBI:17950"	""	"HMDB0004866"	"m02328l"	"HC02162"	"C01290"	"LMSP0501AB00"	"MNXM269"	""	"C01290"	"m02328l"	"MAM02328"
-"MAM02328r"	"galgluside_hs"	"CHEBI:17950"	""	"HMDB0004866"	"m02328r"	"HC02162"	"C01290"	"LMSP0501AB00"	"MNXM269"	""	"C01290"	"m02328r"	"MAM02328"
-"MAM02328e"	"galgluside_hs"	"CHEBI:17950"	""	"HMDB0004866"	"m02328s"	"HC02162"	"C01290"	"LMSP0501AB00"	"MNXM269"	""	"C01290"	"m02328s"	"MAM02328"
+"MAM02328c"	"digalside_hs"	"CHEBI:17950"	""	"HMDB0004866"	"m02328c"	"HC02162"	"C01290"	"LMSP0501AB00"	"MNXM269"	""	"C01290"	"m02328c"	"MAM02328"
+"MAM02328g"	"digalside_hs"	"CHEBI:17950"	""	"HMDB0004866"	"m02328g"	"HC02162"	"C01290"	"LMSP0501AB00"	"MNXM269"	""	"C01290"	"m02328g"	"MAM02328"
+"MAM02328l"	"digalside_hs"	"CHEBI:17950"	""	"HMDB0004866"	"m02328l"	"HC02162"	"C01290"	"LMSP0501AB00"	"MNXM269"	""	"C01290"	"m02328l"	"MAM02328"
+"MAM02328r"	"digalside_hs"	"CHEBI:17950"	""	"HMDB0004866"	"m02328r"	"HC02162"	"C01290"	"LMSP0501AB00"	"MNXM269"	""	"C01290"	"m02328r"	"MAM02328"
+"MAM02328e"	"digalside_hs"	"CHEBI:17950"	""	"HMDB0004866"	"m02328s"	"HC02162"	"C01290"	"LMSP0501AB00"	"MNXM269"	""	"C01290"	"m02328s"	"MAM02328"
 "MAM02329c"	"lald__L"	"CHEBI:18419"	""	""	"m02329c"	""	"C05999"	""	"MNXM2387"	"439231"	"lald_L"	"m02329c"	"MAM02329"
 "MAM02329m"	"lald__L"	"CHEBI:18419"	""	""	"m02329m"	""	"C05999"	""	"MNXM2387"	"439231"	"lald_L"	"m02329m"	"MAM02329"
 "MAM02330g"	"gal14acglcgalgluside_hs"	""	""	""	"m02330g"	""	""	""	"MNXM6313"	""	"gal14acglcgalgluside_hs"	"m02330g"	"MAM02330"
@@ -4275,8 +4258,8 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM02578x"	""	"CHEBI:16134"	""	""	"m02578p"	"HC00024"	"C00014"	""	""	""	""	"m02578p"	"MAM02578"
 "MAM02578r"	""	"CHEBI:16134"	""	""	"m02578r"	"HC00024"	"C00014"	""	""	""	""	"m02578r"	"MAM02578"
 "MAM02578e"	""	"CHEBI:16134"	""	""	"m02578s"	"HC00024"	"C00014"	""	""	""	""	"m02578s"	"MAM02578"
-"MAM02579c"	"nh4"	"CHEBI:16134"	""	"HMDB0000051"	"m02579c"	"HC00765"	"C00014"	""	"MNXM15"	"222"	"nh4"	"m02579c"	"MAM02579"
-"MAM02579e"	"nh4"	"CHEBI:16134"	""	"HMDB0000051"	"m02579s"	"HC00765"	"C00014"	""	"MNXM15"	"222"	"nh4"	"m02579s"	"MAM02579"
+"MAM02579c"	"nh4"	"CHEBI:28938"	""	"HMDB0000051"	"m02579c"	"HC00765"	"C01342"	""	"MNXM15"	"222"	"nh4"	"m02579c"	"MAM02579"
+"MAM02579e"	"nh4"	"CHEBI:28938"	""	"HMDB0000051"	"m02579s"	"HC00765"	"C01342"	""	"MNXM15"	"222"	"nh4"	"m02579s"	"MAM02579"
 "MAM02580c"	""	""	""	""	"m02580c"	""	"C14789"	""	"MNXM7572"	""	"M02580"	"m02580c"	"MAM02580"
 "MAM02581c"	"nmn"	"CHEBI:16171"	""	"HMDB0000229"	"m02581c"	"HC00366"	"C00455"	""	"MNXM355"	"14180"	"nmn"	"m02581c"	"MAM02581"
 "MAM02581m"	"nmn"	"CHEBI:16171"	""	"HMDB0000229"	"m02581m"	"HC00366"	"C00455"	""	"MNXM355"	"14180"	"nmn"	"m02581m"	"MAM02581"
@@ -4396,10 +4379,10 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM02646l"	"ocdcea"	"CHEBI:30823"	""	"HMDB0000207"	"m02646l"	"HC00510"	"C00712"	"LMFA01030002"	"MNXM306;MNXM727011"	"5460221"	"ocdcea"	"m02646l"	"MAM02646"
 "MAM02646r"	"ocdcea"	"CHEBI:30823"	""	"HMDB0000207"	"m02646r"	"HC00510"	"C00712"	"LMFA01030002"	"MNXM306;MNXM727011"	"5460221"	"ocdcea"	"m02646r"	"MAM02646"
 "MAM02646e"	"ocdcea"	"CHEBI:30823"	""	"HMDB0000207"	"m02646s"	"HC00510"	"C00712"	"LMFA01030002"	"MNXM306;MNXM727011"	"5460221"	"ocdcea"	"m02646s"	"MAM02646"
-"MAM02647c"	"odecoa"	"CHEBI:15534"	""	"HMDB0001322"	"m02647c"	"HC00400"	"C00510"	"LMFA07050055"	"MNXM1848;MNXM686"	"5280355"	"odecoa"	"m02647c"	"MAM02647"
-"MAM02647m"	"odecoa"	"CHEBI:15534"	""	"HMDB0001322"	"m02647m"	"HC00400"	"C00510"	"LMFA07050055"	"MNXM1848;MNXM686"	"5280355"	"odecoa"	"m02647m"	"MAM02647"
-"MAM02647x"	"odecoa"	"CHEBI:15534"	""	"HMDB0001322"	"m02647p"	"HC00400"	"C00510"	"LMFA07050055"	"MNXM1848;MNXM686"	"5280355"	"odecoa"	"m02647p"	"MAM02647"
-"MAM02647r"	"odecoa"	"CHEBI:15534"	""	"HMDB0001322"	"m02647r"	"HC00400"	"C00510"	"LMFA07050055"	"MNXM1848;MNXM686"	"5280355"	"odecoa"	"m02647r"	"MAM02647"
+"MAM02647c"	"odecoa"	"CHEBI:15534"	""	"HMDB0001322"	"m02647c"	"HC00400"	"C00510"	"LMFA07050356"	"MNXM1848;MNXM686"	"5280355"	"odecoa"	"m02647c"	"MAM02647"
+"MAM02647m"	"odecoa"	"CHEBI:15534"	""	"HMDB0001322"	"m02647m"	"HC00400"	"C00510"	"LMFA07050356"	"MNXM1848;MNXM686"	"5280355"	"odecoa"	"m02647m"	"MAM02647"
+"MAM02647x"	"odecoa"	"CHEBI:15534"	""	"HMDB0001322"	"m02647p"	"HC00400"	"C00510"	"LMFA07050356"	"MNXM1848;MNXM686"	"5497111"	"odecoa"	"m02647p"	"MAM02647"
+"MAM02647r"	"odecoa"	"CHEBI:15534"	""	"HMDB0001322"	"m02647r"	"HC00400"	"C00510"	"LMFA07050356"	"MNXM1848;MNXM686"	"5280355"	"odecoa"	"m02647r"	"MAM02647"
 "MAM02648c"	"eicostet"	""	""	"HMDB0002177"	"m02648c"	""	""	"LMFA01030176"	"MNXM11474"	"11722594"	"eicostet"	"m02648c"	"MAM02648"
 "MAM02648l"	"eicostet"	""	""	"HMDB0002177"	"m02648l"	""	""	"LMFA01030176"	"MNXM11474"	"11722594"	"eicostet"	"m02648l"	"MAM02648"
 "MAM02648r"	"eicostet"	""	""	"HMDB0002177"	"m02648r"	""	""	"LMFA01030176"	"MNXM11474"	"11722594"	"eicostet"	"m02648r"	"MAM02648"
@@ -4447,17 +4430,17 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM02675l"	"hdcea"	"CHEBI:28716"	""	"HMDB0003229"	"m02675l"	"HC01981"	"C08362"	"LMFA01030056"	"MNXM950"	"445638"	"hdcea"	"m02675l"	"MAM02675"
 "MAM02675r"	"hdcea"	"CHEBI:28716"	""	"HMDB0003229"	"m02675r"	"HC01981"	"C08362"	"LMFA01030056"	"MNXM950"	"445638"	"hdcea"	"m02675r"	"MAM02675"
 "MAM02675e"	"hdcea"	"CHEBI:28716"	""	"HMDB0003229"	"m02675s"	"HC01981"	"C08362"	"LMFA01030056"	"MNXM950"	"445638"	"hdcea"	"m02675s"	"MAM02675"
-"MAM02676c"	"hdcecrn"	""	""	""	"m02676c"	"HC10854"	""	""	"MNXM8716"	"11953816"	"hdcecrn"	"m02676c"	"MAM02676"
-"MAM02676m"	"hdcecrn"	""	""	""	"m02676m"	"HC10854"	""	""	"MNXM8716"	"11953816"	"hdcecrn"	"m02676m"	"MAM02676"
-"MAM02676r"	"hdcecrn"	""	""	""	"m02676r"	"HC10854"	""	""	"MNXM8716"	"11953816"	"hdcecrn"	"m02676r"	"MAM02676"
+"MAM02676c"	"hdcecrn"	""	""	""	"m02676c"	"HC10854"	""	""	"MNXM8716"	"129849228"	"hdcecrn"	"m02676c"	"MAM02676"
+"MAM02676m"	"hdcecrn"	""	""	""	"m02676m"	"HC10854"	""	""	"MNXM8716"	"129849228"	"hdcecrn"	"m02676m"	"MAM02676"
+"MAM02676r"	"hdcecrn"	""	""	""	"m02676r"	"HC10854"	""	""	"MNXM8716"	"129849228"	"hdcecrn"	"m02676r"	"MAM02676"
 "MAM02677c"	"hdcoa"	"CHEBI:53152"	"CE0852"	"HMDB0006532"	"m02677c"	"HC10852"	""	"LMFA07050059"	"MNXM781;MNXM90167"	"53477852"	"hdcoa"	"m02677c"	"MAM02677"
 "MAM02677m"	"hdcoa"	"CHEBI:53152"	"CE0852"	"HMDB0006532"	"m02677m"	"HC10852"	""	"LMFA07050059"	"MNXM781;MNXM90167"	"53477852"	"hdcoa"	"m02677m"	"MAM02677"
 "MAM02677x"	"hdcoa"	"CHEBI:53152"	"CE0852"	"HMDB0006532"	"m02677p"	"HC10852"	""	"LMFA07050059"	"MNXM781;MNXM90167"	"53477852"	"hdcoa"	"m02677p"	"MAM02677"
 "MAM02677r"	"hdcoa"	"CHEBI:53152"	"CE0852"	"HMDB0006532"	"m02677r"	"HC10852"	""	"LMFA07050059"	"MNXM781;MNXM90167"	"53477852"	"hdcoa"	"m02677r"	"MAM02677"
-"MAM02678c"	"pmtcoa"	"CHEBI:15525"	""	"HMDB0001338"	"m02678c"	"HC00150"	"C00154"	"LMFA07050002"	"MNXM88"	"15667"	"pmtcoa"	"m02678c"	"MAM02678"
-"MAM02678m"	"pmtcoa"	"CHEBI:15525"	""	"HMDB0001338"	"m02678m"	"HC00150"	"C00154"	"LMFA07050002"	"MNXM88"	"15667"	"pmtcoa"	"m02678m"	"MAM02678"
-"MAM02678x"	"pmtcoa"	"CHEBI:15525"	""	"HMDB0001338"	"m02678p"	"HC00150"	"C00154"	"LMFA07050002"	"MNXM88"	"15667"	"pmtcoa"	"m02678p"	"MAM02678"
-"MAM02678r"	"pmtcoa"	"CHEBI:15525"	""	"HMDB0001338"	"m02678r"	"HC00150"	"C00154"	"LMFA07050002"	"MNXM88"	"15667"	"pmtcoa"	"m02678r"	"MAM02678"
+"MAM02678c"	"pmtcoa"	"CHEBI:15525"	""	"HMDB0001338"	"m02678c"	"HC00150"	"C00154"	"LMFA07050002"	"MNXM88"	"644109"	"pmtcoa"	"m02678c"	"MAM02678"
+"MAM02678m"	"pmtcoa"	"CHEBI:15525"	""	"HMDB0001338"	"m02678m"	"HC00150"	"C00154"	"LMFA07050002"	"MNXM88"	"644109"	"pmtcoa"	"m02678m"	"MAM02678"
+"MAM02678x"	"pmtcoa"	"CHEBI:15525"	""	"HMDB0001338"	"m02678p"	"HC00150"	"C00154"	"LMFA07050002"	"MNXM88"	"644109"	"pmtcoa"	"m02678p"	"MAM02678"
+"MAM02678r"	"pmtcoa"	"CHEBI:15525"	""	"HMDB0001338"	"m02678r"	"HC00150"	"C00154"	"LMFA07050002"	"MNXM88"	"644109"	"pmtcoa"	"m02678r"	"MAM02678"
 "MAM02679c"	"ptth"	"CHEBI:16753"	""	"HMDB0003426"	"m02679c"	"HC00554"	"C00831"	""	"MNXM727034"	"439322"	""	"m02679c"	"MAM02679"
 "MAM02679m"	"ptth"	"CHEBI:16753"	""	"HMDB0003426"	"m02679m"	"HC00554"	"C00831"	""	"MNXM727034"	"439322"	""	"m02679m"	"MAM02679"
 "MAM02680c"	"pnto__R"	"CHEBI:7916"	""	"HMDB0000210"	"m02680c"	"HC00568"	"C00864"	""	"MNXM364"	"988"	"pnto_R"	"m02680c"	"MAM02680"
@@ -4576,9 +4559,9 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM02745l"	""	""	""	"HMDB0000521"	"m02745l"	""	""	"LMFA01030248"	"MNXM23686;MNXM499525"	"5312400"	"M02745"	"m02745l"	"MAM02745"
 "MAM02745r"	""	""	""	"HMDB0000521"	"m02745r"	""	""	"LMFA01030248"	"MNXM23686;MNXM499525"	"5312400"	"M02745"	"m02745r"	"MAM02745"
 "MAM02745e"	""	""	""	"HMDB0000521"	"m02745s"	""	""	"LMFA01030248"	"MNXM23686;MNXM499525"	"5312400"	"M02745"	"m02745s"	"MAM02745"
-"MAM02746c"	"phyt"	"CHEBI:16285"	"CE2414"	"HMDB0000801"	"m02746c"	""	"C01607"	"LMPR0104010004"	"MNXM165293;MNXM1774"	"26840"	"CE2414"	"m02746c"	"MAM02746"
-"MAM02746x"	"phyt"	"CHEBI:16285"	"CE2414"	"HMDB0000801"	"m02746p"	""	"C01607"	"LMPR0104010004"	"MNXM165293;MNXM1774"	"26840"	"CE2414"	"m02746p"	"MAM02746"
-"MAM02746e"	"phyt"	"CHEBI:16285"	"CE2414"	"HMDB0000801"	"m02746s"	""	"C01607"	"LMPR0104010004"	"MNXM165293;MNXM1774"	"26840"	"CE2414"	"m02746s"	"MAM02746"
+"MAM02746c"	"phyt"	"CHEBI:16285"	"CE2414"	"HMDB0000801"	"m02746c"	""	"C01607"	"LMPR0104010004"	"MNXM165293;MNXM1774;MNXM91275"	"26840"	"CE2414;phyt"	"m02746c;phyt_c;MAM03884c"	"MAM02746"
+"MAM02746x"	"phyt"	"CHEBI:16285"	"CE2414"	"HMDB0000801"	"m02746p"	""	"C01607"	"LMPR0104010004"	"MNXM165293;MNXM1774"	"26840"	"CE2414"	"m02746p;MAM03884x"	"MAM02746"
+"MAM02746e"	"phyt"	"CHEBI:16285"	"CE2414"	"HMDB0000801"	"m02746s"	""	"C01607"	"LMPR0104010004"	"MNXM165293;MNXM1774;MNXM91275"	"26840"	"CE2414;phyt"	"m02746s;phyt_s;MAM03884e"	"MAM02746"
 "MAM02747c"	"phytcoa"	"CHEBI:15538"	"CE5122"	""	"m02747c"	""	"C02060"	""	"MNXM91276;MNXM931"	"439640"	"phytcoa"	"m02747c"	"MAM02747"
 "MAM02747x"	"phytcoa"	"CHEBI:15538"	"CE5122"	""	"m02747p"	""	"C02060"	""	"MNXM91276;MNXM931"	"439640"	"phytcoa"	"m02747p"	"MAM02747"
 "MAM02748c"	""	"CHEBI:31998"	""	""	"m02748c"	""	"C12145"	"LMSP01030000"	"MNXM731"	""	"M02748"	"m02748c"	"MAM02748"
@@ -4604,9 +4587,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM02754e"	"4nph"	"CHEBI:16836"	""	""	"m02754s"	"HC00570"	"C00870"	""	"MNXM162908"	""	"4nph"	"m02754s"	"MAM02754"
 "MAM02755c"	""	"CHEBI:15986"	""	""	"m02755c"	""	"C00419"	""	"MNXM162987"	""	"M02755"	"m02755c"	"MAM02755"
 "MAM02756c"	"ppbng"	"CHEBI:17381"	""	"HMDB0000245"	"m02756c"	"HC00588"	"C00931"	""	"MNXM554"	"1021"	"ppbng"	"m02756c"	"MAM02756"
-"MAM02757c"	""	""	""	""	"m02757c"	""	""	""	""	""	"M02757"	"m02757c"	"MAM02757"
-"MAM02757l"	""	""	""	""	"m02757l"	""	""	""	""	""	"M02757"	"m02757l"	"MAM02757"
-"MAM02757n"	""	""	""	""	"m02757n"	""	""	""	""	""	"M02757"	"m02757n"	"MAM02757"
 "MAM02759c"	"ppi"	"CHEBI:18361"	""	"HMDB0000250"	"m02759c"	"HC00023"	"C00013"	""	"MNXM11"	"644102"	"ppi"	"m02759c"	"MAM02759"
 "MAM02759m"	"ppi"	"CHEBI:18361"	""	"HMDB0000250"	"m02759m"	"HC00023"	"C00013"	""	"MNXM11"	"644102"	"ppi"	"m02759m"	"MAM02759"
 "MAM02759n"	"ppi"	"CHEBI:18361"	""	"HMDB0000250"	"m02759n"	"HC00023"	"C00013"	""	"MNXM11"	"644102"	"ppi"	"m02759n"	"MAM02759"
@@ -5079,8 +5059,8 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM03019x"	""	"CHEBI:87717"	""	""	"m03019p"	""	""	""	""	""	"M03019"	"m03019p"	"MAM03019"
 "MAM03020m"	""	"CHEBI:77549"	"CE2591"	""	"m03020m"	"HC12591"	""	""	"MNXM683714"	""	"CE2591"	"m03020m"	"MAM03020"
 "MAM03020x"	""	"CHEBI:77549"	"CE2591"	""	"m03020p"	"HC12591"	""	""	"MNXM683714"	""	"CE2591"	"m03020p"	"MAM03020"
-"MAM03021m"	""	"CHEBI:28387"	""	"HMDB0011123"	"m03021m"	""	"C05279"	""	"MNXM2039"	"53480665"	"C05279"	"m03021m"	"MAM03021"
-"MAM03021x"	""	"CHEBI:28387"	""	"HMDB0011123"	"m03021p"	""	"C05279"	""	"MNXM2039"	"53480665"	"C05279"	"m03021p"	"MAM03021"
+"MAM03021m"	""	"CHEBI:28387"	""	"HMDB0011123"	"m03021m"	""	"C05279"	""	"MNXM2039"	"5280770"	"C05279"	"m03021m"	"MAM03021"
+"MAM03021x"	""	"CHEBI:28387"	""	"HMDB0011123"	"m03021p"	""	"C05279"	""	"MNXM2039"	"5280770"	"C05279"	"m03021p"	"MAM03021"
 "MAM03022m"	""	"CHEBI:87701"	""	""	"m03022m"	""	""	""	""	""	"M03022"	"m03022m"	"MAM03022"
 "MAM03022x"	""	"CHEBI:87701"	""	""	"m03022p"	""	""	""	""	""	"M03022"	"m03022p"	"MAM03022"
 "MAM03023m"	""	""	"CE2594"	""	"m03023m"	"HC12594"	""	""	""	""	"CE2594;HC12594"	"m03023m"	"MAM03023"
@@ -5324,7 +5304,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM03157e"	""	"CHEBI:29105"	""	"HMDB0015532"	"m03157s"	"HC02172"	"C00038"	""	"MNXM149"	"32051"	"zn2"	"m03157s"	"MAM03157"
 "MAM03161c"	""	"CHEBI:28087"	""	""	"m03161c"	""	"C00182"	""	"MNXM55375"	""	"M03161"	"m03161c"	"MAM03161"
 "MAM03161e"	""	"CHEBI:28087"	""	""	"m03161s"	""	"C00182"	""	"MNXM55375"	""	"M03161"	"m03161s"	"MAM03161"
-"MAM03162c"	""	"CHEBI:27404"	""	""	"m03162c"	""	"C05578"	""	"MNXM2336"	""	"M03162"	"m03162c"	"MAM03162"
 "MAM03163c"	"ind56qn"	"CHEBI:27406"	""	""	"m03163c"	""	"C05579"	""	"MNXM5183"	""	"M03163;ind56qn"	"m03163c"	"MAM03163"
 "MAM03164c"	"alaala"	"CHEBI:16576"	""	""	"m03164c"	""	"C00993"	""	"MNXM739338"	"5460362"	"M03164;alaala"	"m03164c"	"MAM03164"
 "MAM03165c"	""	"CHEBI:16802"	""	""	"m03165c"	""	""	""	"MNXM44065"	""	"M03165"	"m03165c"	"MAM03165"
@@ -5338,7 +5317,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM03140c"	""	""	""	""	"m03140c"	""	""	""	""	""	"M03140"	"m03140c"	"MAM03140"
 "MAM03143c"	""	""	""	""	"m03143c"	""	""	""	""	""	"M03143"	"m03143c"	"MAM03143"
 "MAM01004m"	"34hpl"	"CHEBI:17385"	""	"HMDB0000755"	""	""	"C03672"	""	"MNXM114141"	"9378"	"34hpl"	"m01004m"	"MAM01004"
-"MAM03226m"	"3hibutcoa"	"CHEBI:15481"	""	""	""	""	"C04047"	""	"MNXM446"	""	"3hibutcoa"	"3hibutcoa_m"	"MAM03226"
 "MAM00799c"	"3hpcoa"	"CHEBI:27762"	""	""	""	"HC01557"	"C05668"	""	"MNXM1263"	"440753"	"3hpcoa"	"m00799c"	"MAM00799"
 "MAM02142c"	"3hpp"	"CHEBI:33404"	""	"HMDB0000700"	""	"HC00625"	"C01013"	""	"MNXM872"	"68152"	"3hpp"	"m02142c"	"MAM02142"
 "MAM00900c"	"msa"	"CHEBI:17960"	""	""	""	"HC00203"	"C00222"	""	"MNXM244"	"868"	"msa"	"m00900c"	"MAM00900"
@@ -5387,7 +5365,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00953r"	""	""	""	""	""	"HC02108"	"C15808"	""	"MNXM2089;MNXM37762;MNXM7449"	""	"4mzym_int1"	"m00953r"	"MAM00953"
 "MAM04082r"	"zym_int2"	""	""	""	""	""	""	""	"MNXM97119"	"22298942"	"zym_int2"	"zym_int2_r"	"MAM04082"
 "MAM03158r"	"zymst"	"CHEBI:18252"	""	""	""	"HC01451"	"C05437"	"LMST01010066"	"MNXM574"	"92746"	"zymst"	"m03158r"	"MAM03158"
-"MAM02579r"	"nh4"	"CHEBI:16134"	""	"HMDB0000051"	""	"HC00765"	"C00014"	""	"MNXM15"	"222"	"nh4"	"m02579r"	"MAM02579"
+"MAM02579r"	"nh4"	"CHEBI:28938"	""	"HMDB0000051"	""	"HC00765"	"C01342"	""	"MNXM15"	"222"	"nh4"	"m02579r"	"MAM02579"
 "MAM01427m"	"cdpdag_hs"	""	""	""	""	"HC02078"	"C00269"	"LMGP13010000"	"MNXM5661"	""	"cdpdag_hs"	"m01427m"	"MAM01427"
 "MAM02733m"	"pa_hs"	"CHEBI:16337"	""	""	""	"HC02049"	"C00416"	"LMGP10010000"	"MNXM77635"	""	"pa_hs"	"m02733m"	"MAM02733"
 "MAM00121x"	"clpndcoa"	"CHEBI:63541"	"CE4822"	"HMDB0006267"	""	""	"C16166"	"LMFA07050048"	"MNXM4529;MNXM97364"	"53477812"	"clpndcoa"	"m00121p"	"MAM00121"
@@ -5400,11 +5378,11 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01431e"	"crmp_hs"	""	""	""	""	"HC02165"	""	""	"MNXM92165"	""	"crmp_hs"	"m01431s"	"MAM01431"
 "MAM00950x"	"dmnoncrn"	""	""	""	""	""	""	""	"MNXM8138"	""	"dmnoncrn"	"m00950p"	"MAM00950"
 "MAM03554x"	"dmnoncoa"	""	""	""	""	""	""	""	"MNXM6100"	""	"dmnoncoa"	"dmnoncoa_p"	"MAM03554"
-"MAM02579n"	"nh4"	"CHEBI:16134"	""	"HMDB0000051"	""	"HC00765"	"C00014"	""	"MNXM15"	"222"	"nh4"	"m02579n"	"MAM02579"
+"MAM02579n"	"nh4"	"CHEBI:28938"	""	"HMDB0000051"	""	"HC00765"	"C01342"	""	"MNXM15"	"222"	"nh4"	"m02579n"	"MAM02579"
 "MAM00240r"	"dag_hs"	"CHEBI:17815"	""	""	""	"HC02055"	"C00641"	"LMGL02010000"	"MNXM59"	""	"dag_hs"	"m00240r"	"MAM00240"
 "MAM02733n"	"pa_hs"	"CHEBI:16337"	""	""	""	"HC02049"	"C00416"	"LMGP10010000"	"MNXM77635"	""	"pa_hs"	"m02733n"	"MAM02733"
 "MAM00240e"	"dag_hs"	"CHEBI:17815"	""	""	""	"HC02055"	"C00641"	"LMGL02010000"	"MNXM59"	""	"dag_hs"	"m00240s"	"MAM00240"
-"MAM02579x"	"nh4"	"CHEBI:16134"	""	"HMDB0000051"	""	"HC00765"	"C00014"	""	"MNXM15"	"222"	"nh4"	"m02579p"	"MAM02579"
+"MAM02579x"	"nh4"	"CHEBI:28938"	""	"HMDB0000051"	""	"HC00765"	"C01342"	""	"MNXM15"	"222"	"nh4"	"m02579p"	"MAM02579"
 "MAM02959c"	"tag_hs"	"CHEBI:17855"	""	""	""	"HC02062"	"C00422"	"LMGL03010000"	"MNXM9170"	""	"tag_hs"	"m02959c"	"MAM02959"
 "MAM02343r"	"lthstrl"	"CHEBI:17168"	""	"HMDB0001170"	""	"HC00706"	"C01189"	"LMST01010089"	"MNXM162760;MNXM810"	"65728"	"lthstrl"	"m02343r"	"MAM02343"
 "MAM01675r"	"dsmsterol"	"CHEBI:17737"	""	"HMDB0002719"	""	"HC00847"	"C01802"	"LMST01010016"	"MNXM162959;MNXM695"	"439577"	"dsmsterol"	"m01675r"	"MAM01675"
@@ -5417,7 +5395,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01706x"	"dmpp"	"CHEBI:16057"	""	"HMDB0001120"	""	"HC00213"	"C00235"	"LMPR01010001"	"MNXM132"	"647"	"dmpp"	"m01706p"	"MAM01706"
 "MAM01953x"	"grdp"	"CHEBI:17211"	""	""	""	"HC00288"	"C00341"	""	"MNXM100"	"445995"	"grdp"	"m01953p"	"MAM01953"
 "MAM03553m"	"dmhptcoa"	""	""	""	""	""	""	""	"MNXM8044"	""	"dmhptcoa"	"dmhptcoa_m"	"MAM03553"
-"MAM03554c"	"dmnoncoa"	""	""	""	""	""	""	""	"MNXM6100"	""	"dmnoncoa"	"dmnoncoa_c"	"MAM03554"
 "MAM03554m"	"dmnoncoa"	""	""	""	""	""	""	""	"MNXM6100"	""	"dmnoncoa"	"dmnoncoa_m"	"MAM03554"
 "MAM01731c"	"dolglcp__L"	"CHEBI:15812"	""	""	""	""	"C01246"	"LMPR03080014"	"MNXM146386"	""	"dolglcp_L"	"m01731c"	"MAM01731"
 "MAM00164x"	"5dpmev"	"CHEBI:15899"	""	""	""	"HC00685"	"C01143"	""	"MNXM689"	"439418"	"5dpmev"	"m00164p"	"MAM00164"
@@ -5439,7 +5416,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM03623e"	"glygn5"	""	""	""	""	""	""	""	"MNXM11717"	""	"glygn5"	"glygn5_s"	"MAM03623"
 "MAM00656e"	"lpchol_hs"	"CHEBI:17504"	""	""	""	"HC02016"	"C04230"	"LMGP01050000"	"MNXM5213"	""	"lpchol_hs"	"m00656s"	"MAM00656"
 "MAM02715e"	"pglyc_hs"	""	""	""	""	"HC02096"	"C00344"	"LMGP04010000"	"MNXM9017"	""	"pglyc_hs"	"m02715s"	"MAM02715"
-"MAM03884e"	"phyt"	"CHEBI:16285"	""	"HMDB0000801"	""	""	"C01607"	""	"MNXM91275"	"26840"	"phyt"	"phyt_s"	"MAM03884"
 "MAM02808e"	"ps_hs"	"CHEBI:18303"	""	""	""	"HC02006"	"C02737"	"LMGP03010000"	"MNXM5273"	""	"ps_hs"	"m02808s"	"MAM02808"
 "MAM01232e"	"retinol_9_cis"	""	"CE1754"	""	""	""	""	""	"MNXM162711;MNXM2626"	"9947823"	"retinol_9_cis"	"m01232s"	"MAM01232"
 "MAM00291e"	"retinol_cis_11"	""	""	""	""	""	"C00899"	"LMPR01090005"	"MNXM162437;MNXM870"	"5280382"	"retinol_cis_11"	"m00291s"	"MAM00291"
@@ -5450,7 +5426,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM03726c"	"lnlcACP"	""	""	""	""	""	""	""	"MNXM19075"	""	"lnlcACP"	"lnlcACP_c"	"MAM03726"
 "MAM03725c"	"lneldcACP"	""	""	""	""	""	""	""	"MNXM19074"	""	"lneldcACP"	"lneldcACP_c"	"MAM03725"
 "MAM03887c"	"pristcoa"	"CHEBI:64039"	""	""	""	""	""	""	"MNXM7699"	"25137904"	"pristcoa"	"pristcoa_c"	"MAM03887"
-"MAM03884c"	"phyt"	"CHEBI:16285"	""	"HMDB0000801"	""	""	"C01607"	""	"MNXM91275"	"26840"	"phyt"	"phyt_c"	"MAM03884"
 "MAM03791m"	"octd11ecoa"	""	""	""	""	""	""	""	""	""	"octd11ecoa"	"octd11ecoa_m"	"MAM03791"
 "MAM00108x"	"strdnccoa"	"CHEBI:63545"	"CE4815"	""	""	""	"C16163"	"LMFA07050046"	"MNXM3361"	"23724640"	"strdnccoa"	"m00108p"	"MAM00108"
 "MAM00103x"	"tmndnccoa"	""	"CE4813"	""	""	""	"C16165"	"LMFA07050063"	"MNXM1449;MNXM2869"	"52922050"	"tmndnccoa"	"m00103p"	"MAM00103"
@@ -5501,7 +5476,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM02733g"	"pa_hs"	"CHEBI:16337"	""	""	""	"HC02049"	"C00416"	"LMGP10010000"	"MNXM77635"	""	"pa_hs"	"m02733g"	"MAM02733"
 "MAM02684m"	"pchol_hs"	"CHEBI:16110"	""	""	""	"HC02000"	"C00157"	""	"MNXM2028"	""	"pchol_hs"	"m02684m"	"MAM02684"
 "MAM03850r"	"pecgoncoa"	""	""	""	""	""	""	""	"MNXM92624"	"443846"	"pecgoncoa"	"pecgoncoa_r"	"MAM03850"
-"MAM03887x"	"pristcoa"	"CHEBI:64039"	""	""	""	""	""	""	"MNXM7699"	"25137904"	"pristcoa"	"pristcoa_p"	"MAM03887"
+"MAM03887x"	"pristcoa"	"CHEBI:77250"	""	""	""	""	""	""	"MNXM7699"	"25137904"	"pristcoa"	"pristcoa_p"	"MAM03887"
 "MAM02717c"	"pgp_hs"	""	""	""	""	"HC02095"	"C03892"	"LMGP05010000"	"MNXM12647"	""	"pgp_hs"	"m02717c"	"MAM02717"
 "MAM02725m"	"phpyr"	"CHEBI:30851"	""	"HMDB0000205"	""	""	"C00166"	""	"MNXM162242;MNXM210"	"997"	"phpyr"	"m02725m"	"MAM02725"
 "MAM00553r"	"pail4p_hs"	"CHEBI:17526"	""	""	""	""	"C01277"	""	"MNXM2456"	""	"pail4p_hs"	"m00553r"	"MAM00553"
@@ -5542,15 +5517,13 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM03127e"	""	"CHEBI:28766"	""	""	""	"HC01609"	"C05766"	""	"MNXM1123;MNXM165232"	"440775"	"HC01609"	"m03127s"	"MAM03127"
 "MAM01605e"	"cpppg1"	"CHEBI:28607"	""	"HMDB0002158"	""	"HC01610"	"C05768"	""	"MNXM1322"	"440776"	"cpppg1"	"m01605s"	"MAM01605"
 "MAM02011e"	"gm2_hs"	"CHEBI:51013"	""	"HMDB0004936"	""	"HC02160"	"C04884"	"LMSP0601AM00"	"MNXM164819"	"20057332"	"HC02160"	"m02011s"	"MAM02011"
-"MAM02008e"	"gm1_hs"	"CHEBI:18216"	""	""	""	"HC02161"	"C04911"	"LMSP0601AP00"	"MNXM164818"	""	"HC02161"	"m02008s"	"MAM02008"
+"MAM02008e"	"HC02161"	"CHEBI:18216"	""	""	""	"HC02161"	"C04911"	"LMSP0601AP00"	"MNXM164818"	""	"HC02161"	"m02008s"	"MAM02008"
 "MAM03108e"	"udpg"	"CHEBI:18066"	""	""	""	"HC00038"	"C00029"	""	"MNXM52"	"53477679"	"udpg"	"m03108s"	"MAM03108"
 "MAM02411x"	"pmtcrn"	"CHEBI:17490"	""	"HMDB0000222"	""	"HC01034"	"C02990"	"LMFA07070004"	"MNXM162587;MNXM787"	"11953816"	"pmtcrn"	"m02411p"	"MAM02411"
 "MAM02388x"	"lnlccrn"	""	""	""	""	"HC10855"	""	""	"MNXM8847"	"6450015"	"lnlccrn"	"m02388p"	"MAM02388"
 "MAM01363x"	"arachdcrn"	""	""	""	""	"HC12236"	""	""	"MNXM8358"	""	"arachdcrn"	"m01363p"	"MAM01363"
 "MAM01747e"	"dtdp"	"CHEBI:18075"	""	"HMDB0001274"	""	"HC00307"	"C00363"	""	"MNXM152"	"164628"	"dtdp"	"m01747s"	"MAM01747"
 "MAM00755c"	"dhcholoylcoa"	"CHEBI:27393"	""	""	""	""	"C05447"	"LMST01010220"	"MNXM163354;MNXM2748"	"5280796"	"dhcholoylcoa"	"m00755c"	"MAM00755"
-"MAM03318r"	"C02528"	"CHEBI:16755"	""	"HMDB0000518"	""	""	"C02528"	""	"MNXM1183"	"10133"	"C02528"	"C02528_r"	"MAM03318"
-"MAM03318c"	"C02528"	"CHEBI:16755"	""	"HMDB0000518"	""	""	"C02528"	""	"MNXM1183"	"10133"	"C02528"	"C02528_c"	"MAM03318"
 "MAM00726m"	"34dhmald"	""	""	""	""	"HC01514"	"C05577"	""	"MNXM1633"	"151725"	"34dhmald"	"m00726m"	"MAM00726"
 "MAM00727m"	"34dhoxmand"	""	""	""	""	"HC01517"	"C05580"	""	"MNXM3473;MNXM90911"	"85782"	"34dhoxmand"	"m00727m"	"MAM00727"
 "MAM02137m"	"homoval"	"CHEBI:545959"	""	"HMDB0000118"	""	"HC01519"	"C05582"	""	"MNXM162963;MNXM3287"	"1738"	"homoval"	"m02137m"	"MAM02137"
@@ -5558,7 +5531,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00820m"	"3m4hpga"	""	""	""	""	"HC01520"	"C05583"	""	"MNXM162904;MNXM1989"	"440729"	"3m4hpga"	"m00820m"	"MAM00820"
 "MAM03136m"	"3mox4hoxm"	"CHEBI:1127735"	""	"HMDB0000291"	""	"HC01521"	"C05584"	""	"MNXM163196;MNXM3383"	"736172"	"3mox4hoxm"	"m03136m"	"MAM03136"
 "MAM02336x"	"lanost"	"CHEBI:16521"	""	"HMDB0001251"	""	"HC00833"	"C01724"	"LMST01010017"	"MNXM482"	"246983"	"lanost"	"m02336p"	"MAM02336"
-"MAM03318e"	"C02528"	"CHEBI:16755"	""	"HMDB0000518"	""	""	"C02528"	""	"MNXM1183"	"10133"	"C02528"	"C02528_s"	"MAM03318"
 "MAM00755m"	"dhcholoylcoa"	"CHEBI:27393"	""	""	""	""	"C05447"	"LMST01010220"	"MNXM163354;MNXM2748"	"5280796"	"dhcholoylcoa"	"m00755m"	"MAM00755"
 "MAM00968r"	""	""	""	""	""	"HC02110"	"C05103"	""	"MNXM1804"	"22212495"	"HC02110"	"m00968r"	"MAM00968"
 "MAM00051r"	"hdd2coa"	"CHEBI:28935"	""	"HMDB0003945"	""	"HC01411"	"C05272"	"LMFA07050020"	"MNXM581"	"46173176"	"hdd2coa"	"m00051r"	"MAM00051"
@@ -5568,7 +5540,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM03389c"	""	""	""	""	""	"HC01988"	""	""	"MNXM6439"	""	"HC01988"	"HC01988_c"	"MAM03389"
 "MAM03326m"	""	""	"CE0692"	""	""	""	""	""	""	""	"CE0692"	"CE0692_m"	"MAM03326"
 "MAM03393e"	"HC02154"	""	""	""	""	"HC02154"	""	""	"MNXM164821"	""	"HC02154"	"HC02154_s"	"MAM03393"
-"MAM00270e"	"wharachd"	"CHEBI:34306"	""	""	""	""	"C14748"	""	"MNXM22451"	"5283157"	"wharachd"	"m00270s"	"MAM00270"
+"MAM00270e"	"wharachd"	"CHEBI:34306"	""	""	"m00591s"	"HC02179"	"C14748"	""	"MNXM22451;MNXM6760"	"5283157"	"wharachd"	"m00270s;m00591s;MAM00591e"	"MAM00270"
 "MAM00083c"	""	""	"CE2421"	""	""	""	""	""	"MNXM31120"	"53481430"	"CE2421"	"m00083c"	"MAM00083"
 "MAM00884c"	""	""	"CE0713"	""	""	""	""	""	"MNXM166247"	""	"CE0713"	"m00884c"	"MAM00884"
 "MAM01597e"	"coa"	"CHEBI:1146900"	""	"HMDB0001423"	""	"HC00020"	"C00010"	""	"MNXM12"	"6816"	"coa"	"m01597s"	"MAM01597"
@@ -5579,7 +5551,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01725n"	""	"CHEBI:65088"	"CE2254"	""	""	""	"C16528"	"LMFA07050052"	"MNXM10780"	"53481548"	"docoscoa"	"m01725n"	"MAM01725"
 "MAM00890r"	"3ohodcoa"	"CHEBI:50571"	""	"HMDB0006498"	""	""	"C16216"	""	"MNXM513"	"22833663"	"3ohodcoa"	"m00890r"	"MAM00890"
 "MAM00793r"	""	""	"CE2248"	""	""	""	""	""	"MNXM1309"	"24906329"	"CE2248"	"m00793r"	"MAM00793"
-"MAM00057n"	"od2coa"	"CHEBI:50570"	""	"HMDB0006529"	""	""	"C16218"	"LMFA07050055"	"MNXM954"	"53477850"	"od2coa"	"m00057n"	"MAM00057"
+"MAM00057n"	"od2coa"	"CHEBI:50570"	""	"HMDB0006529"	""	""	"C16218"	"LMFA07050385"	"MNXM954"	"53477850"	"od2coa"	"m00057n"	"MAM00057"
 "MAM02941n"	"stcoa"	"CHEBI:15541"	""	"HMDB0001114"	""	"HC00338"	"C00412"	"LMFA07050004"	"MNXM272"	"439229"	"stcoa"	"m02941n"	"MAM02941"
 "MAM02158e"	""	""	"CE2011"	""	""	""	""	""	"MNXM57006"	"124985"	"CE2011"	"m02158s"	"MAM02158"
 "MAM02986l"	"tcynt"	"CHEBI:18022"	""	"HMDB0001453"	""	""	"C01755"	""	"MNXM762"	"9322"	"tcynt"	"m02986l"	"MAM02986"
@@ -5784,9 +5756,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00943r"	""	""	"CE2314"	"HMDB0006840"	""	""	"C15915"	"LMST01010225"	"MNXM5534"	"23724604"	"CE2314"	"m00943r"	"MAM00943"
 "MAM03377c"	"CE6027"	""	"CE6027"	""	""	""	""	""	"MNXM164173"	""	"CE6027"	"CE6027_c"	"MAM03377"
 "MAM03377m"	"CE6027"	""	"CE6027"	""	""	""	""	""	"MNXM164173"	""	"CE6027"	"CE6027_m"	"MAM03377"
-"MAM03354c"	"CE4837"	"CHEBI:63548"	"CE4837"	"HMDB0006516"	""	""	"C16171"	""	"MNXM165171"	"53477846"	"CE4837"	"CE4837_c"	"MAM03354"
 "MAM00681r"	""	""	"CE4830"	""	""	""	""	""	"MNXM145987;MNXM163157"	""	"CE4830"	"m00681r"	"MAM00681"
-"MAM03354r"	"CE4837"	"CHEBI:63548"	"CE4837"	"HMDB0006516"	""	""	"C16171"	""	"MNXM165171"	"53477846"	"CE4837"	"CE4837_r"	"MAM03354"
 "MAM00864r"	""	""	"CE4833"	""	""	""	""	""	"MNXM164263"	""	"CE4833"	"m00864r"	"MAM00864"
 "MAM00714r"	""	""	"CE4831"	""	""	""	""	""	"MNXM164188"	""	"CE4831"	"m00714r"	"MAM00714"
 "MAM00074r"	""	""	"CE4835"	""	""	""	""	""	"MNXM145822"	""	"CE4835"	"m00074r"	"MAM00074"
@@ -5819,12 +5789,9 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM03365r"	"CE5161"	""	"CE5161"	""	""	""	""	""	"MNXM163175"	""	"CE5161"	"CE5161_r"	"MAM03365"
 "MAM03366c"	"CE5162"	""	"CE5162"	""	""	""	""	""	"MNXM163591"	""	"CE5162"	"CE5162_c"	"MAM03366"
 "MAM03366r"	"CE5162"	""	"CE5162"	""	""	""	""	""	"MNXM163591"	""	"CE5162"	"CE5162_r"	"MAM03366"
-"MAM03367m"	""	""	"CE5168"	""	""	""	""	""	""	""	"CE5168"	"CE5168_m"	"MAM03367"
 "MAM03367x"	""	""	"CE5168"	""	""	""	""	""	""	""	"CE5168"	"CE5168_p"	"MAM03367"
 "MAM03367c"	"CE5168"	""	"CE5168"	""	""	""	""	""	"MNXM166027"	""	"CE5168"	"CE5168_c"	"MAM03367"
 "MAM03368c"	""	"CHEBI:27379"	"CE5169"	"HMDB0006891"	""	""	"C05467"	""	""	"440690"	"CE5169"	"CE5169_c"	"MAM03368"
-"MAM03368m"	""	"CHEBI:27379"	"CE5169"	"HMDB0006891"	""	""	"C05467"	""	""	"440690"	"CE5169"	"CE5169_m"	"MAM03368"
-"MAM03368x"	""	"CHEBI:27379"	"CE5169"	"HMDB0006891"	""	""	"C05467"	""	""	"440690"	"CE5169"	"CE5169_p"	"MAM03368"
 "MAM01428e"	"cdpea"	"CHEBI:16732"	""	"HMDB0001564"	""	"HC00433"	"C00570"	""	"MNXM449"	"123727"	"cdpea"	"m01428s"	"MAM01428"
 "MAM00475e"	"12dgr120"	""	""	""	""	""	""	""	"MNXM4939"	""	"12dgr120"	"12dgr120_s"	"MAM00475"
 "MAM02171g"	"inost"	"CHEBI:17268"	""	"HMDB0000211"	""	"HC00135"	"C00137"	""	"MNXM127"	"892"	"inost"	"m02171g"	"MAM02171"
@@ -5845,14 +5812,13 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00252r"	""	""	"CE4988"	""	""	""	""	""	"MNXM162617"	""	"CE4988"	"m00252r"	"MAM00252"
 "MAM00846c"	""	""	"CE5966"	""	""	""	""	""	"MNXM91381"	""	"CE5966"	"m00846c"	"MAM00846"
 "MAM00691c"	""	""	"CE5971"	""	""	""	""	""	"MNXM162897"	""	"CE5971"	"m00691c"	"MAM00691"
-"MAM01123m"	""	""	"CE2084"	""	""	""	""	""	"MNXM162741"	""	"CE7097"	"m01123m"	"MAM01123"
-"MAM01123x"	""	""	"CE2084"	""	""	""	""	""	"MNXM162741"	""	"CE7097"	"m01123p"	"MAM01123"
+"MAM01123m"	""	""	"CE7097"	""	""	""	""	""	"MNXM162741"	""	"CE7097"	"m01123m"	"MAM01123"
+"MAM01123x"	""	""	"CE7097"	""	""	""	""	""	"MNXM162741"	""	"CE7097"	"m01123p"	"MAM01123"
 "MAM01040n"	""	"CHEBI:28209"	""	"HMDB0011134"	""	""	"C04805"	"LMFA03060002"	"MNXM38414"	"5280733"	"C04805"	"m01040n"	"MAM01040"
 "MAM01126m"	""	""	"CE2084"	""	""	""	""	"LMFA03060011"	"MNXM94297"	"1831"	"CE2084"	"m01126m"	"MAM01126"
 "MAM01040x"	""	"CHEBI:28209"	""	"HMDB0011134"	""	""	"C04805"	"LMFA03060002"	"MNXM38414"	"5280733"	"C04805"	"m01040p"	"MAM01040"
 "MAM01126x"	""	""	"CE2084"	""	""	""	""	"LMFA03060011"	"MNXM94297"	"1831"	"CE2084"	"m01126p"	"MAM01126"
 "MAM02364n"	"leuktrB4"	"CHEBI:15647"	""	"HMDB0001085"	""	"HC02182"	"C02165"	"LMFA03020001"	"MNXM162284;MNXM637"	"5280492"	"leuktrB4"	"m02364n"	"MAM02364"
-"MAM03325c"	"C08276"	"CHEBI:1438"	""	"HMDB0001527"	""	""	"C08276"	""	"MNXM2782"	"563"	"C08276"	"C08276_c"	"MAM03325"
 "MAM03510c"	"ch4s"	""	""	""	""	""	""	""	"MNXM652"	"878"	"ch4s"	"ch4s_c"	"MAM03510"
 "MAM03405c"	"acryl"	""	""	""	""	""	""	""	"MNXM1368"	"6581"	"acryl"	"acryl_c"	"MAM03405"
 "MAM00309m"	"12HPET"	"CHEBI:15626"	""	"HMDB0004243"	""	""	"C05965"	"LMFA03060013"	"MNXM13989;MNXM2765"	"5280892"	"12HPET"	"m00309m"	"MAM00309"
@@ -5877,7 +5843,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM02862r"	""	""	""	""	""	""	"C11304"	""	"MNXM81247"	"5281898"	"C11304"	"m02862r"	"MAM02862"
 "MAM00420c"	""	""	"CE6183"	""	""	""	""	""	"MNXM33740"	"53481487"	"CE6183"	"m00420c"	"MAM00420"
 "MAM00581c"	""	""	"CE6187"	""	""	""	""	""	"MNXM35480"	""	"CE6187"	"m00581c"	"MAM00581"
-"MAM03332c"	"CE2516"	"CHEBI:53486"	"CE2516"	"HMDB0002925"	""	""	"C03242"	""	"MNXM5607"	"5280581"	"CE2516"	"CE2516_c"	"MAM03332"
 "MAM02785n"	"prostge1"	"CHEBI:15544"	""	"HMDB0001442"	""	"HC02211"	"C04741"	"LMFA03010134"	"MNXM162507;MNXM3344"	"5280723"	"prostge1"	"m02785n"	"MAM02785"
 "MAM02793n"	""	""	"CE6234"	""	""	""	""	""	"MNXM78300"	"5283048"	"CE6234"	"m02793n"	"MAM02793"
 "MAM00329m"	""	""	"CE5525"	""	""	""	""	""	"MNXM33276"	"53481457"	"CE5525"	"m00329m"	"MAM00329"
@@ -5943,7 +5908,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM03489e"	"c10dc"	""	""	""	""	""	""	""	"MNXM162993"	""	"c10dc"	"c10dc_s"	"MAM03489"
 "MAM00181c"	""	"CHEBI:28325"	""	""	""	"HC01403"	"C05264"	"LMFA07050014"	"MNXM674"	"11966158"	"3hdcoa"	"m00181c"	"MAM00181"
 "MAM03204c"	"3deccrn"	""	""	""	""	""	""	""	"MNXM150909"	""	"3deccrn"	"3deccrn_c"	"MAM03204"
-"MAM03540c"	"ddeccrn"	""	""	""	""	""	""	""	""	"168381"	"ddeccrn"	"ddeccrn_c"	"MAM03540"
 "MAM00042c"	"dd2coa"	"CHEBI:15471"	""	""	""	"HC01078"	"C03221"	"LMFA07050010"	"MNXM642"	"45266564"	"dd2coa"	"m00042c"	"MAM00042"
 "MAM03541c"	"ddece1crn"	""	""	""	""	""	""	""	""	""	"ddece1crn"	"ddece1crn_c"	"MAM03541"
 "MAM03491x"	"c12dccoa"	"CHEBI:76315"	""	""	""	""	""	""	""	""	"c12dccoa"	"c12dccoa_p"	"MAM03491"
@@ -6009,7 +5973,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM03502e"	"c8dc"	""	""	""	""	""	""	""	"MNXM162999"	""	"c8dc"	"c8dc_s"	"MAM03502"
 "MAM01648r"	""	"CHEBI:30813"	""	"HMDB0000511"	""	"HC02175"	"C01571"	"LMFA01010010"	"MNXM1043;MNXM162295"	"2969"	"dca"	"m01648r"	"MAM01648"
 "MAM03202e"	"3ddcrn"	""	""	""	""	""	""	""	"MNXM150910"	""	"3ddcrn"	"3ddcrn_s"	"MAM03202"
-"MAM03540e"	"ddeccrn"	""	""	""	""	""	""	""	""	"168381"	"ddeccrn"	"ddeccrn_s"	"MAM03540"
 "MAM03541e"	"ddece1crn"	""	""	""	""	""	""	""	""	""	"ddece1crn"	"ddece1crn_s"	"MAM03541"
 "MAM03204e"	"3deccrn"	""	""	""	""	""	""	""	"MNXM150909"	""	"3deccrn"	"3deccrn_s"	"MAM03204"
 "MAM03544e"	"decdicrn"	""	""	""	""	""	""	""	""	"53481669"	"decdicrn"	"decdicrn_s"	"MAM03544"
@@ -6183,7 +6146,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM02741e"	"pan4p"	"CHEBI:16858"	""	""	""	"HC00681"	"C01134"	""	"MNXM373"	"987"	"pan4p"	"m02741s"	"MAM02741"
 "MAM03933e"	"slfcys"	"CHEBI:27891"	""	"HMDB0000731"	""	""	"C05824"	""	"MNXM2428"	"115015"	"slfcys"	"slfcys_s"	"MAM03933"
 "MAM01828e"	"fmn"	"CHEBI:17621"	""	"HMDB0001520"	""	"HC00064"	"C00061"	""	"MNXM119"	"643976"	"fmn"	"m01828s"	"MAM01828"
-"MAM02679e"	"ptth"	"CHEBI:15525"	""	"HMDB0001338"	""	"HC00554"	"C00154"	""	"MNXM1154"	"15667"	"ptth"	"m02679s"	"MAM02679"
+"MAM02679e"	"ptth"	"CHEBI:16753"	""	"HMDB0003426"	""	"HC00554"	"C00154"	""	"MNXM1154"	"439322"	"ptth"	"m02679s"	"MAM02679"
 "MAM03102e"	"q10h2"	"CHEBI:17976"	""	""	""	"HC00324"	"C00390"	""	"MNXM9200"	"9962735"	"q10h2"	"m03102s"	"MAM03102"
 "MAM02439x"	"mal__L"	"CHEBI:30797"	""	"HMDB0000156"	""	"HC00146"	"C00149"	""	"MNXM98"	"222656"	"mal_L"	"m02439p"	"MAM02439"
 "MAM03933c"	"slfcys"	"CHEBI:27891"	""	"HMDB0000731"	""	""	"C05824"	""	"MNXM2428"	"115015"	"slfcys"	"slfcys_c"	"MAM03933"
@@ -6235,7 +6198,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM02639e"	"odecrn"	""	""	"HMDB0005065"	""	""	""	""	"MNXM65475;MNXM8956"	""	"odecrn"	"m02639s"	"MAM02639"
 "MAM02940e"	"stcrn"	""	""	""	""	""	""	"LMFA07070008"	"MNXM82716;MNXM9119"	"6426855"	"stcrn"	"m02940s"	"MAM02940"
 "MAM02411e"	"pmtcrn"	"CHEBI:17490"	""	"HMDB0000222"	""	"HC01034"	"C02990"	"LMFA07070004"	"MNXM162587;MNXM787"	"11953816"	"pmtcrn"	"m02411s"	"MAM02411"
-"MAM02676e"	"hdcecrn"	""	""	""	""	"HC10854"	""	""	"MNXM8716"	"11953816"	"hdcecrn"	"m02676s"	"MAM02676"
+"MAM02676e"	"hdcecrn"	""	""	""	""	"HC10854"	""	""	"MNXM8716"	"129849228"	"hdcecrn"	"m02676s"	"MAM02676"
 "MAM01620e"	"pcreat"	"CHEBI:58092"	""	""	""	""	"C02305"	""	"MNXM819;MNXM90130;MNXM91273"	"9548602"	"pcreat"	"m01620s"	"MAM01620"
 "MAM01580e"	""	"CHEBI:32805"	""	""	""	"HC00342"	"C00417"	""	"MNXM162425;MNXM813"	"309"	"HC00342"	"m01580s"	"MAM01580"
 "MAM01372e"	""	"CHEBI:48131"	""	"HMDB0000784"	""	""	"C08261"	"LMFA01170054"	"MNXM164574"	"2266"	"C08261"	"m01372s"	"MAM01372"
@@ -6399,7 +6362,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00784e"	"3hmp"	"CHEBI:37373"	""	"HMDB0000023"	""	"HC00705"	"C06001"	""	"MNXM396"	"440873"	"3hmp"	"m00784s"	"MAM00784"
 "MAM03234c"	"3hpppnohgluc"	""	""	""	""	""	""	""	""	""	"3hpppnohgluc"	"3hpppnohgluc_c"	"MAM03234"
 "MAM03234e"	"3hpppnohgluc"	""	""	""	""	""	""	""	""	""	"3hpppnohgluc"	"3hpppnohgluc_s"	"MAM03234"
-"MAM03232c"	"3hpppn"	"CHEBI:57277"	""	""	""	""	""	""	"MNXM1634"	""	"3hpppn"	"3hpppn_c"	"MAM03232"
+"MAM03232c"	"3hpppn"	"CHEBI:57277"	""	""	""	""	""	""	"MNXM1634"	""	"3hpppn"	"3hpppn_c;MAM03231c"	"MAM03232"
 "MAM03233c"	"3hpppnoh"	""	""	""	""	""	""	""	""	""	"3hpppnoh"	"3hpppnoh_c"	"MAM03233"
 "MAM02142e"	"3hpp"	"CHEBI:33404"	""	"HMDB0000700"	""	"HC00625"	"C01013"	""	"MNXM872"	"68152"	"3hpp"	"m02142s"	"MAM02142"
 "MAM03247e"	"3mhis"	"CHEBI:70959"	""	""	""	""	""	""	""	""	"3mhis"	"3mhis_s"	"MAM03247"
@@ -6456,7 +6419,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01392e"	""	"CHEBI:37084"	"CE2028"	"HMDB0000754"	""	""	""	""	"MNXM36533"	"69362"	"CE2028"	"m01392s"	"MAM01392"
 "MAM00830e"	""	""	"CE2176"	"HMDB0001434"	""	""	""	""	"MNXM10073"	"1670"	"CE2176"	"m00830s"	"MAM00830"
 "MAM01172e"	""	"CHEBI:63981"	"CE2445"	"HMDB0005087"	""	""	""	"LMFA03020013"	"MNXM48977"	"5283128"	"CE2445"	"m01172s"	"MAM01172"
-"MAM03332e"	""	"CHEBI:53486"	"CE2516"	"HMDB0002925"	""	""	"C03242"	""	""	"5280581"	"CE2516"	"CE2516_s"	"MAM03332"
 "MAM00378e"	""	""	"CE2537"	""	""	""	""	"LMFA03050007"	"MNXM165539;MNXM33401"	"1437"	"CE2537"	"m00378s"	"MAM00378"
 "MAM03569e"	"eidi1114ac"	"CHEBI:603631"	""	"HMDB0005060"	""	""	"C16525"	""	""	"6439848"	"eidi1114ac"	"eidi1114ac_s"	"MAM03569"
 "MAM00384e"	""	""	"CE5304"	""	""	""	""	""	"MNXM33412"	"5283052"	"CE5304"	"m00384s"	"MAM00384"
@@ -6563,7 +6525,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM03215e"	"3hcinnm"	""	""	""	""	""	""	""	"MNXM1799"	""	"3hcinnm"	"3hcinnm_s"	"MAM03215"
 "MAM03215c"	"3hcinnm"	""	""	""	""	""	""	""	"MNXM1799"	""	"3hcinnm"	"3hcinnm_c"	"MAM03215"
 "MAM03231e"	""	""	""	""	""	""	""	""	""	""	"3hppa"	"3hppa_s"	"MAM03231"
-"MAM03231c"	""	"CHEBI:57277"	""	""	""	""	""	""	""	""	"3hppa"	"3hppa_c"	"MAM03231"
 "MAM02622e"	"normete__L"	"CHEBI:144308"	""	"HMDB0000819"	""	""	"C05589"	""	"MNXM3674"	"1237"	"normete_L"	"m02622s"	"MAM02622"
 "MAM00400e"	""	"CHEBI:776"	""	"HMDB0000335"	""	""	"C05300"	"LMST02010041"	"MNXM3794"	"115116"	"C05300"	"m00400s"	"MAM00400"
 "MAM01698e"	"dhbpt"	""	""	""	""	"HC00242"	"C00268"	""	"MNXM162257;MNXM90267"	"1879"	"dhbpt"	"m01698s"	"MAM01698"
@@ -8122,6 +8083,8 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM00995n"	""	"CHEBI:17879"	""	""	""	""	""	""	"MNXM164"	""	""	""	"MAM00995"
 "MAM01316n"	""	"CHEBI:60721"	""	""	""	""	""	""	"MNXM731626"	""	""	""	"MAM01316"
 "MAM00767n"	""	"CHEBI:84503"	""	""	""	""	""	""	"MNXM733937"	""	""	""	"MAM00767"
+"MAM01729e"	""	""	""	"HMDB0002250"	""	""	""	""	"MNXM51468;MNXM588354"	"168381"	"M01729"	"MAM03540e"	"MAM01729"
+"MAM00853c"	""	""	"CE4820"	""	""	""	""	""	"MNXM164259"	""	"CE4820"	";MAM00902c"	"MAM00853"
 "MAM15003c"	""	"CHEBI:28718"	""	""	""	""	"C05519"	""	"MNXM2125"	"99289"	""	""	"MAM15003"
 "MAM01104x"	""	"CHEBI:250388"	""	""	""	""	"C11821"	""	"MNXM1137"	"250388"	""	""	"MAM01104"
 "MAM10018x"	""	"CHEBI:58639"	""	""	""	""	"C12248"	""	"MNXM1805"	"443736"	""	""	"MAM10018"
@@ -8158,7 +8121,7 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM15052c"	""	"CHEBI:83276"	""	""	""	""	"C16502"	""	"MNXM735428"	"21895630"	""	""	"MAM15052"
 "MAM15053c"	""	"CHEBI:80535"	""	""	""	""	"C16503"	""	"MNXM5369"	"5275508"	""	""	"MAM15053"
 "MAM00809r"	"4mzym_int2"	"CHEBI:50593"	""	""	""	"HC02109"	"C15816"	"LMST01010167"	"MNXM162901;MNXM36392;MNXM8744"	""	"4mzym_int2"	"m00809r"	"MAM00809"
-"MAM01066r"	"chlstol"	"CHEBI:16290"	""	""	""	"HC01452"	"C05439"	""	"MNXM162749;MNXM830"	""	"chlstol"	"m01066r"	"MAM01066"
+"MAM01449r"	"zymstnl"	"CHEBI:16608"	""	"HMDB0006841"	""	"HC02126"	"C03845"	"LMST01010096"	"MNXM2494"	"101770"	"zymstnl"	"m01449r"	"MAM01449"
 "MAM02932r"	"Ssq23epx"	"CHEBI:15441"	""	""	""	"HC00645"	"C01054"	""	"MNXM130"	"53477723"	"Ssq23epx"	"m02932r"	"MAM02932"
 "MAM00356c"	""	""	"CE5842"	""	"m00356c"	""	""	""	"MNXM9688"	"53481465"	"CE5842"	"m00356c"	"MAM00356"
 "MAM00360c"	""	""	"CE5655"	""	"m00360c"	""	""	""	"MNXM163114"	"53481467"	"CE5655"	"m00360c"	"MAM00360"
diff --git a/model/reactions.tsv b/model/reactions.tsv
index 224c62f..a27c87a 100644
--- a/model/reactions.tsv
+++ b/model/reactions.tsv
@@ -26,7 +26,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR04391"	"TPI"	"R01015C"	"HMR_4391"	"r0243"	"R01015"	"MNXR104918"	""	"RCR14186"	"TPI"	"HMR_4391"	""	"RHEA:18585"	""	0
 "MAR04394"	"HEX1"	""	"HMR_4394"	"r0353"	"R00299"	"MNXR100612"	""	"RCR10145"	"HEX1"	"HMR_4394"	""	"RHEA:17825"	""	0
 "MAR04396"	"PGMT"	"R00959C"	"HMR_4396"	"r0621"	"R08639"	"MNXR102528;MNXR102548"	""	"RCR10146"	"PGMT"	"HMR_4396"	""	""	""	0
-"MAR04521"	"G6PPer"	""	"HMR_4521"	"r0396"	"R00303"	"MNXR99912"	""	"RCR11028"	"G6PPer"	"HMR_4521"	""	"RHEA:16689"	""	0
+"MAR04521"	"G6PPer;G6PP;R_G6PP;R_G6PPer"	""	"HMR_4521"	"r0396"	"R00303"	"MNXR99912;MNXR195425"	""	"RCR11028"	"G6PPer"	"HMR_4521;MAR20020"	""	"RHEA:16689"	""	0
 "MAR06412"	""	"R02569C"	"HMR_6412"	"r0555"	"R02569"	"MNXR102430;MNXR107584"	""	"RCR14187"	"r0555"	"HMR_6412"	""	"RHEA:17017"	""	0
 "MAR07745"	""	""	"HMR_7745"	""	"R01602"	"MNXR107082"	""	"RCR10447"	"HMR_7745"	"HMR_7745"	"RHEA:10267"	"RHEA:10264"	""	0
 "MAR07747"	""	""	"HMR_7747"	""	"R09086"	"MNXR112530"	""	"RCR10449"	"HMR_7747"	"HMR_7747"	"RHEA:11460"	"RHEA:11461"	""	0
@@ -145,7 +145,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR08517"	"MGSA2"	""	"HMR_8517"	""	"R01016"	"MNXR101551;MNXR101552"	""	"RCR11086"	"MGSA2"	"HMR_8517"	""	"RHEA:17937"	""	0
 "MAR04280"	"LDH_Lm"	"R00703C"	"HMR_4280"	"r0172"	"R00703"	"MNXR101040"	""	"RCR11087"	"LDH_Lm"	"HMR_4280"	""	"RHEA:23444"	""	0
 "MAR00153"	"ACS2"	""	"HMR_0153"	"r0218"	"R00925"	"MNXR106753;MNXR95222"	""	"RCR10460"	"ACS2"	"HMR_0153"	"RHEA:20374"	"RHEA:20373"	""	0
-"MAR03212"	"PPCOAOm"	""	"HMR_3212"	""	"R00924"	"MNXR103101"	""	"RCR11088"	"PPCOAOm"	"HMR_3212"	""	""	""	0
+"MAR03212"	"PPCOAOm"	""	"HMR_3212;HMR_3211"	"r0683"	"R00924"	"MNXR103101"	""	"RCR11088;RCR14348"	"PPCOAOm;r0683"	"HMR_3212;MAR03211"	""	""	""	0
 "MAR03797"	"ACCOALm"	""	"HMR_3797"	"r0219"	"R00925"	"MNXR106753;MNXR95222"	""	"RCR14211"	"ACCOALm"	"HMR_3797"	"RHEA:20376"	"RHEA:20373"	""	0
 "MAR03800"	"OBDHm"	""	"HMR_3800"	"r1154"	""	"MNXR102133"	""	"RCR10461"	"r1154"	"HMR_3800"	""	""	""	0
 "MAR04282"	"MMSAD3m"	"R00705M"	"HMR_4282"	"r0174"	"R00705"	"MNXR101665"	""	"RCR10462"	"MMSAD3m"	"HMR_4282"	"RHEA:22993"	"RHEA:22992"	""	0
@@ -291,7 +291,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR06616"	""	"RE0453N"	"HMR_6616"	""	""	"MNXR103447"	""	"RCR11149"	"RE0453N"	"HMR_6616"	""	""	""	0
 "MAR04635"	"NDPK4"	"R02093C"	"HMR_4635"	"r0495"	"R02093"	"MNXR101937"	""	"RCR10101"	"NDPK4"	"HMR_4635"	"RHEA:27685"	"RHEA:27682"	""	0
 "MAR03793"	"D3AIBTm"	"R02050M"	"HMR_3793"	"r0484"	"R02050"	"MNXR107287;MNXR97068"	""	"RCR11150"	"D3AIBTm"	"HMR_3793"	""	"RHEA:18393"	""	0
-"MAR03931"	"TRDR"	"R02016C"	"HMR_3931"	"r0469"	"R02016"	"MNXR104766"	""	"RCR11151"	"TRDR"	"HMR_3931"	""	"RHEA:20345"	""	0
 "MAR03969"	"URIK3"	""	"HMR_3969"	""	"R00970"	"MNXR105164"	""	"RCR14251"	"URIK3"	"HMR_3969"	""	""	""	0
 "MAR03970"	"NTD2"	""	"HMR_3970"	""	"R00963"	"MNXR102032"	""	"RCR11152"	"NTD2"	"HMR_3970"	"RHEA:29360"	"RHEA:29359"	""	0
 "MAR04008"	"UMPK"	"R00158M"	"HMR_4008"	"r0038"	"R00158"	"MNXR105118"	""	"RCR10109"	"UMPK"	"HMR_4008"	"RHEA:24403"	"RHEA:24400"	""	0
@@ -330,7 +329,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR04672"	""	""	"HMR_4672"	""	"R02325"	""	""	"RCR10128"	"HMR_4672"	"HMR_4672"	""	"RHEA:22680"	""	0
 "MAR04676"	""	"R02372E"	"HMR_4676"	"r0531"	"R02372"	"MNXR97821"	""	"RCR11173"	"r0531"	"HMR_4676"	""	""	""	0
 "MAR04736"	"DHPM2"	"R03055C"	"HMR_4736"	"r0593"	"R03055"	"MNXR107917;MNXR97433"	""	"RCR11174"	"DHPM2"	"HMR_4736"	""	""	""	0
-"MAR04819"	"BUP2"	"R04666C"	"HMR_4819"	"r0710"	"R04666"	"MNXR109033;MNXR96346"	""	"RCR11175"	""	"HMR_4819"	""	""	""	0
+"MAR04819"	"BUP2"	"R04666C"	"HMR_4819"	"r0710"	"R04666"	"MNXR109033;MNXR96346"	""	"RCR11175"	"BUP2"	"HMR_4819;BUP2;MAR00096"	""	""	""	0
 "MAR05299"	"URIK1"	"R00964E"	"HMR_5299"	"r1115"	"R00964"	"MNXR105162"	""	"RCR11176"	"URIK1"	"HMR_5299"	"RHEA:16826"	"RHEA:16825"	""	0
 "MAR05352"	""	"R02332E"	"HMR_5352"	"r1156"	"R02332"	"MNXR97823"	""	"RCR11177"	"r1156"	"HMR_5352"	""	""	""	0
 "MAR05415"	""	"R02018M"	"HMR_5415"	"r1431"	"R02017"	"MNXR104066"	""	"RCR11178"	""	"HMR_5415"	""	"RHEA:28034"	""	0
@@ -440,7 +439,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR08472"	"CYTK9n"	""	"HMR_8472"	""	""	""	""	"RCR10239"	"CYTK9n"	"HMR_8472"	""	""	""	0
 "MAR08474"	"ATPH1e"	""	"HMR_8474"	""	"R00085"	"MNXR96128"	""	"RCR30513"	"ATPH1e"	"HMR_8474"	"RHEA:20989"	"RHEA:20988"	""	0
 "MAR08481"	"DGSNtm"	""	"HMR_8481"	""	""	"MNXR97324"	""	"RCR11232"	"DGK2m"	"HMR_8481"	""	""	""	0
-"MAR08482"	"TRDRm"	""	"HMR_8482"	""	"R02016"	"MNXR104766"	""	"RCR11233"	"TRDRm"	"HMR_8482"	""	"RHEA:20345"	""	0
+"MAR08482"	"TRDRm"	""	"HMR_8482"	""	"R02016"	"MNXR104766"	""	"RCR11233"	"TRDRm;r1433"	"HMR_8482;MAR02358"	""	"RHEA:20345"	""	0
 "MAR08483"	"EBASTINEOHte"	""	"HMR_8483"	""	"R02100"	"MNXR97869"	""	"RCR14276"	"DUTPDPn"	"HMR_8483"	"RHEA:10249"	"RHEA:10248"	""	0
 "MAR08484"	"INSKm"	""	"HMR_8484"	""	"R01131"	"MNXR100845"	""	"RCR11234"	"INSKm"	"HMR_8484"	"RHEA:21141"	"RHEA:21140"	""	0
 "MAR08485"	"NDP7g"	""	"HMR_8485"	""	"R00155"	"MNXR101931"	""	"RCR11235"	"NDP7g"	"HMR_8485"	"RHEA:64877"	"RHEA:64876"	""	0
@@ -489,7 +488,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR03833"	"P5CR"	"R01251C"	"HMR_3833"	"r0305"	"R01251"	"MNXR102302"	""	"RCR11261"	"P5CR"	"HMR_3833"	""	"RHEA:14109"	""	0
 "MAR03835"	"PRO1xm"	"R01248C"	"HMR_3835"	"r0304"	"R01248"	"MNXR102303"	""	"RCR10307"	"PRO1x"	"HMR_3835"	""	"RHEA:14105"	""	0
 "MAR03837"	"PRO1xm"	""	"HMR_3837"	""	"R01248"	"MNXR102303"	""	"RCR10308"	"P5CRxm;PRO1xm"	"HMR_3837"	""	"RHEA:14105"	""	0
-"MAR03838"	""	""	"HMR_3838"	"r1453"	""	""	""	"RCR14286"	""	"HMR_3838"	""	""	""	0
 "MAR03895"	"GLU5Km"	"R00239C"	"HMR_3895"	"r0072"	"R00239"	"MNXR100277"	""	"RCR11262"	"GLU5Km"	"HMR_3895"	""	"RHEA:14877"	""	0
 "MAR03897"	"G5SDym"	"R03313C"	"HMR_3897"	"r0619"	"R03313"	"MNXR99896"	""	"RCR14287"	"G5SDym"	"HMR_3897"	""	"RHEA:19541"	""	0
 "MAR03956"	"HCO3Em"	""	"HMR_3956"	""	"R10092"	"MNXR100482"	""	"RCR10097"	"H2CO3Dm"	"HMR_3956"	"RHEA:10750"	"RHEA:10748"	""	0
@@ -546,17 +544,17 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR08607"	"UNK2"	""	"HMR_8607"	""	""	"MNXR105128"	""	"RCR10315"	"UNK2"	"HMR_8607"	""	""	""	0
 "MAR08608"	"DRIBt"	""	"HMR_8608"	""	"R02894"	"MNXR97783"	""	"RCR14308"	"HMR_8608"	"HMR_8608"	""	""	""	0
 "MAR08609"	"P5CRm"	""	"HMR_8609"	""	"R01251"	"MNXR102302"	""	"RCR10244"	"P5CRm"	"HMR_8609"	""	"RHEA:14109"	""	0
-"MAR08611"	"PROD2m"	""	"HMR_8611"	""	"R10507"	"MNXR103187"	""	"RCR11294"	"PROD2m"	"HMR_8611"	""	""	""	0
+"MAR08611"	"PROD2m"	""	"HMR_8611;HMR_3838"	"r1453"	"R10507"	"MNXR103187"	""	"RCR11294;RCR14286"	"PROD2m"	"HMR_8611;HMR_3838;MAR03838"	""	""	""	0
 "MAR04285"	""	"R00713C"	"HMR_4285"	"r0178"	"R00713"	"MNXR104540"	""	"RCR11295"	"r0178"	"HMR_4285"	"RHEA:13218"	"RHEA:13217"	""	0
 "MAR00457"	""	"R01514C"	"HMR_0457"	"r0339"	"R01514"	"MNXR100328"	""	"RCR11296"	"r0339"	"HMR_0457"	"RHEA:23517"	"RHEA:23516"	""	0
 "MAR00460"	""	"R01514C"	"HMR_0460"	"r0340"	"R01514"	"MNXR100328"	""	"RCR11297"	"r0340"	"HMR_0460"	"RHEA:23517"	"RHEA:23516"	""	0
 "MAR03750"	""	"RE2429M"	"HMR_3750"	""	""	"MNXR103672"	""	"RCR14309"	"RE2429M"	"HMR_3750"	""	""	""	0
-"MAR03752"	"ACOAD9m"	""	"HMR_3752"	""	""	""	""	"RCR14310"	"ACOAD9m"	"HMR_3752"	""	""	""	0
-"MAR03770"	"ACOAD8m"	""	"HMR_3770"	""	"R04095"	""	""	"RCR14311"	"ACOAD8m"	"HMR_3770"	""	""	""	0
+"MAR03752"	"ACOAD9m"	"R02660M"	"HMR_3752;HMR_3751"	"r0560"	"R02660"	""	""	"RCR14310;RCR14421"	"ACOAD9m;r0560"	"HMR_3752;HMR_3751;MAR03751"	""	""	""	0
+"MAR03770"	"ACOAD8m"	"R04095M"	"HMR_3770;HMR_3769"	"r0655"	"R04095"	"MNXR95318"	""	"RCR14311;RCR14423"	"ACOAD8m;r0655"	"HMR_3770;HMR_3769;MAR03769"	""	""	""	0
 "MAR03771"	""	"RE2427M"	"HMR_3771"	""	""	"MNXR103670"	""	"RCR14312"	"RE2427M"	"HMR_3771"	""	""	""	0
 "MAR03772"	""	"RE2111M"	"HMR_3772"	""	""	"MNXR103609"	""	"RCR14313"	"RE2111M"	"HMR_3772"	""	""	""	0
 "MAR03782"	""	"RE2428M"	"HMR_3782"	""	""	"MNXR103671"	""	"RCR14314"	"RE2428M"	"HMR_3782"	""	""	""	0
-"MAR03784"	"ACOAD10m"	""	"HMR_3784"	""	""	""	""	"RCR11298"	"ACOAD10m"	"HMR_3784"	""	""	""	0
+"MAR03784"	"ACOAD10m"	"R03172M"	"HMR_3784;HMR_3783"	"r0603"	"R03172"	"MNXR108000"	""	"RCR11298;RCR14424"	"ACOAD10m;r0603"	"HMR_3784;HMR_3783;MAR03783"	""	""	""	0
 "MAR03839"	"PGCD"	"R01513C"	"HMR_3839"	"r0338"	"R01513"	"MNXR102527"	""	"RCR11299"	"PGCD"	"HMR_3839"	""	"RHEA:12641"	""	0
 "MAR03841"	"PSERT"	"R04173C"	"HMR_3841"	"r0663"	"R04173"	"MNXR103225"	""	"RCR11300"	"PSERT"	"HMR_3841"	""	"RHEA:14329"	""	0
 "MAR03843"	"PSP_L"	"R00582C"	"HMR_3843"	"r0159"	"R00582"	"MNXR103260"	""	"RCR11301"	"PSP_L"	"HMR_3843"	""	"RHEA:21208"	""	0
@@ -666,9 +664,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR08543"	"IDHPOXOX2b"	""	"HMR_8543"	""	""	"MNXR100792"	""	"RCR14343"	"IDHPOXOX2b"	"HMR_8543"	""	""	""	0
 "MAR08544"	"IDHPOXOXb"	""	"HMR_8544"	""	""	"MNXR100795"	""	"RCR14344"	"IDHPOXOXb"	"HMR_8544"	""	""	""	0
 "MAR08540"	"TYRASE"	""	"HMR_8540"	""	""	"MNXR104987"	""	"RCR11371"	"HMR_8540"	"HMR_8540"	""	""	""	0
-"MAR09733"	""	""	"HMR_9733"	""	"R03674"	"MNXR108330"	""	"RCR14346"	"HMR_9733"	"HMR_9733"	""	""	""	0
 "MAR03206"	"ACACT10m"	"R00927M"	"HMR_3206"	"r0222"	"R00927"	"MNXR95195"	""	"RCR11372"	"ACACT10m"	"HMR_3206"	""	"RHEA:30719"	""	0
-"MAR03211"	""	""	"HMR_3211"	"r0683"	"R00924"	"MNXR103101"	""	"RCR14348"	"r0683"	"HMR_3211"	""	""	""	0
 "MAR03747"	"VALTA"	""	"HMR_3747"	""	"R01214"	"MNXR96230"	""	"RCR11376"	"VALTA"	"HMR_3747"	""	"RHEA:24813"	""	0
 "MAR03744"	"VALTAim"	"R01214C"	"HMR_3744"	"r0263"	"R01214"	"MNXR96230"	""	"RCR11377"	"VALTAm"	"HMR_3744"	""	"RHEA:24813"	""	0
 "MAR03757"	"HIBDm"	"R02047M"	"HMR_3757"	"r0482"	"R02047"	"MNXR100634"	""	"RCR11378"	"HIBDm"	"HMR_3757"	""	"RHEA:17681"	""	0
@@ -680,8 +676,8 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR06417"	""	"RE3326M"	"HMR_6417"	"r0561"	"R02662"	"MNXR107649;MNXR97451"	""	"RCR14349"	"RE3326M;r0561"	"HMR_6417"	""	"RHEA:18865"	""	0
 "MAR06419"	""	"R04225C"	"HMR_6419"	"r0670"	"R04225"	"MNXR108745;MNXR94911"	""	"RCR11381"	"r0670"	"HMR_6419"	""	""	""	0
 "MAR06420"	""	""	"HMR_6420"	"r0604"	"R03174"	"MNXR108002;MNXR97450"	""	"RCR14350"	"r0604"	"HMR_6420"	""	""	""	0
-"MAR06421"	""	"R01702C"	"HMR_6421"	"r0386"	"R01702"	"MNXR107132;MNXR95029"	""	"RCR11382"	"r0386"	"HMR_6421"	""	""	""	0
-"MAR06422"	""	""	"HMR_6422"	"r0656"	"R04097"	"MNXR108654;MNXR97452"	""	"RCR14351"	"r0656"	"HMR_6422"	""	""	""	0
+"MAR06421"	"OIVD1m"	"R01702C;R03171M"	"HMR_6421;HMR_3767"	"r0386;r0601"	"R01702;R01651"	"MNXR107132;MNXR95029;MNXR102172;MNXR107999"	""	"RCR11382;RCR14422"	"r0386;OIVD1m"	"HMR_6421;HMR_3767;MAR03767_1"	""	"RHEA:25177"	""	0
+"MAR06422"	"OIVD1m"	"R0317M"	"HMR_6422;HMR_3767"	"r0656;r0601"	"R04097;R01651"	"MNXR108654;MNXR97452;MNXR102172;MNXR107999"	""	"RCR14351;RCR14422"	"r0656;OIVD1m"	"HMR_6422;MAR03767_2"	""	"RHEA:25177"	""	0
 "MAR06923"	"LEUTA"	""	"HMR_6923"	""	"R01090"	"MNXR96229"	""	"RCR10325"	"LEUTA"	"HMR_6923"	""	"RHEA:18321"	""	0
 "MAR03765"	"LEUTAm"	"R01090C"	"HMR_3765"	"r0262"	"R01090"	"MNXR96229"	""	"RCR11383"	"LEUTAm"	"HMR_3765"	""	"RHEA:18321"	""	0
 "MAR06925"	""	"RE2292C"	"HMR_6925"	""	""	"MNXR103647"	""	"RCR14353"	"RE2292C"	"HMR_6925"	""	""	""	0
@@ -697,8 +693,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR04232"	""	"RE0549C"	"HMR_4232"	""	""	"MNXR103449"	""	"RCR10536"	"RE0549C"	"HMR_4232"	""	""	""	0
 "MAR04233"	""	""	"HMR_4233"	"r0645"	"R03889"	"MNXR95796"	""	"RCR11396"	"r0645"	"HMR_4233"	""	"RHEA:14469"	""	0
 "MAR04235"	"AMCOXO"	""	"HMR_4235"	"r0449"	"R01938"	"MNXR95807"	""	"RCR11397"	"AMCOXO"	"HMR_4235"	""	""	""	0
-"MAR04242"	""	"R02487M"	"HMR_4242"	"r0541"	"R02487"	"MNXR100293"	""	"RCR14356"	"r0541"	"HMR_4242"	""	"RHEA:30847"	""	0
-"MAR04243"	"GLUTCOADHm"	""	"HMR_4243"	""	"R02487"	""	""	"RCR11398"	"GLUTCOADHm"	"HMR_4243"	""	"RHEA:30847"	""	0
+"MAR04243"	"GLUTCOADHm"	"R02487M"	"HMR_4243;HMR_4242"	"r0541"	"R02487"	"MNXR100293"	""	"RCR11398;RCR14356"	"GLUTCOADHm;r0541"	"HMR_4243;HMR_4242;MAR04242"	""	"RHEA:30847"	""	0
 "MAR04244"	"3HKYNAKGAT"	"R04171C"	"HMR_4244"	"r0662"	"R04171"	"MNXR108708;MNXR94895"	""	"RCR11399"	"3HKYNAKGAT"	"HMR_4244"	""	"RHEA:65888"	""	0
 "MAR04245"	""	""	"HMR_4245"	"r0647"	"R03954"	"MNXR105360;MNXR108552"	""	"RCR11400"	"r0647"	"HMR_4245"	"RHEA:65893"	"RHEA:65892"	""	0
 "MAR04246"	""	"RE2349C"	"HMR_4246"	""	""	""	""	"RCR11401"	"RE2349C"	"HMR_4246"	""	""	""	0
@@ -799,7 +794,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR03996"	"HMR_3996"	""	"HMR_3996"	""	"R00892"	"MNXR106737"	""	"RCR10546"	"HMR_3996"	"HMR_3996"	""	"RHEA:20597"	""	0
 "MAR04072"	""	""	"HMR_4072"	""	"R00380"	"MNXR97627"	""	"RCR10547"	"HMR_4072"	"HMR_4072"	""	"RHEA:13681"	""	0
 "MAR04189"	""	"R00533C"	"HMR_4189"	"r0142"	"R00533"	"MNXR104649"	""	"RCR11488"	"r0142"	"HMR_4189"	"RHEA:24601"	"RHEA:24600"	""	0
-"MAR04302"	""	"R00782C"	"HMR_4302"	"r0193"	"R00782"	"MNXR105313;MNXR96994"	""	"RCR11489"	""	"HMR_4302"	""	"RHEA:24931"	""	0
+"MAR04302"	"r0193"	"R00782C"	"HMR_4302"	"r0193"	"R00782"	"MNXR105313;MNXR96994"	""	"RCR11489"	"r0193"	"HMR_4302;r0193;MAR02027"	""	"RHEA:24931"	""	0
 "MAR04323"	""	"R00891C"	"HMR_4323"	"r0210"	"R00891"	"MNXR105314;MNXR96986"	""	"RCR11490"	"r0210"	"HMR_4323"	""	""	""	0
 "MAR05381"	""	"RE3009C"	"HMR_5381"	""	"R02021"	"MNXR102376"	""	"RCR10548"	"RE3009C"	"HMR_5381"	""	"RHEA:11724"	""	0
 "MAR05385"	""	""	"HMR_5385"	""	"R04420"	"MNXR101759"	""	"RCR14401"	"MTRI"	"HMR_5385"	"RHEA:19990"	"RHEA:19989"	""	0
@@ -863,17 +858,13 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR08689"	"DASCBH"	""	"HMR_8689"	""	"R02923"	"MNXR97151"	""	"RCR14418"	"DARGOp"	"HMR_8689"	""	""	""	0
 "MAR08690"	"DPCOAPP"	""	"HMR_8690"	""	"R02457"	"MNXR97763"	""	"RCR14419"	"DORNOp"	"HMR_8690"	""	""	""	0
 "MAR03748"	"OIVD2m"	"R03171M"	"HMR_3748"	"r0600"	"R01210"	"MNXR102173;MNXR107999"	""	"RCR14420"	"OIVD2m"	"HMR_3748"	""	"RHEA:13997"	""	0
-"MAR03751"	""	"R02660M"	"HMR_3751"	"r0560"	"R02660"	""	""	"RCR14421"	"r0560"	"HMR_3751"	""	""	""	0
 "MAR03753"	"ECOAH2m"	"R04224M"	"HMR_3753"	"r0669"	"R04224"	"MNXR97885"	""	"RCR11518"	"ECOAH12m;r0669"	"HMR_3753"	""	"RHEA:31175"	""	0
-"MAR03755"	"r0779"	"R03352M"	"HMR_3755"	"r0779"	"R03352"	"MNXR108112"	""	"RCR11519"	"r0779"	"HMR_3755"	""	"RHEA:20888"	""	0
+"MAR03755"	"3HBCOAHLm;r0779"	"R03352M"	"HMR_3755"	"r0779"	"R03352"	"MNXR108112;MNXR94891"	""	"RCR11519"	"3HBCOAHLm;r0779"	"3HBCOAHLm;HMR_3755;MAR00042"	""	"RHEA:20888"	""	0
 "MAR03759"	"r0643"	"R03869C"	"HMR_3759"	"r0643"	"R03869"	"MNXR105358;MNXR95762"	""	"RCR10556"	"r0643"	"HMR_3759"	""	"RHEA:31043"	""	0
 "MAR03763"	"r0571"	""	"HMR_3763"	"r0571"	"R02764"	"MNXR105351"	""	"RCR10557"	""	"HMR_3763"	""	"RHEA:17345"	""	0
-"MAR03767"	"OIVD1m"	"R03171M"	"HMR_3767"	"r0601"	"R01651"	"MNXR102172;MNXR107999"	""	"RCR14422"	"OIVD1m"	"HMR_3767"	""	"RHEA:25177"	""	0
-"MAR03769"	""	"R04095M"	"HMR_3769"	"r0655"	"R04095"	"MNXR95318"	""	"RCR14423"	"r0655"	"HMR_3769"	""	""	""	0
 "MAR03773"	"MCCCrm"	"R04138M"	"HMR_3773"	"r0658"	"R04138"	"MNXR101411"	""	"RCR11520"	"MCCCrm"	"HMR_3773"	""	"RHEA:13589"	""	0
 "MAR03775"	"MGCHrm"	"R02085M"	"HMR_3775"	"r0490"	"R02085"	"MNXR101513;MNXR107307"	""	"RCR11521"	"MGCHrm"	"HMR_3775"	""	"RHEA:21536"	""	0
 "MAR03780"	"OIVD3m"	"R03171M"	"HMR_3780"	"r0602"	"R03171"	"MNXR102174;MNXR107999"	""	"RCR10345"	"OIVD3m"	"HMR_3780"	""	"RHEA:30907"	""	0
-"MAR03783"	""	"R03172M"	"HMR_3783"	"r0603"	"R03172"	"MNXR108000"	""	"RCR14424"	"r0603"	"HMR_3783"	""	""	""	0
 "MAR03785"	"ECOAH9m"	"R04204M"	"HMR_3785"	"r0665"	"R04204"	"MNXR97894"	""	"RCR11522"	"ECOAH9m"	"HMR_3785"	""	"RHEA:31119"	""	0
 "MAR03790"	"r0644"	"R03871C"	"HMR_3790"	"r0644"	"R03871"	"MNXR105359;MNXR108490"	""	"RCR10558"	"r0644"	"HMR_3790"	""	""	""	0
 "MAR03792"	""	"R02048M"	"HMR_3792"	"r0483"	"R02048"	"MNXR105346"	""	"RCR11523"	"3AIBTm;r0483"	"HMR_3792"	""	""	""	0
@@ -1041,7 +1032,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR05170"	""	""	"HMR_5170"	""	""	""	""	"RCR14472"	"HMR_5170"	"HMR_5170"	""	""	""	0
 "MAR05171"	""	""	"HMR_5171"	""	""	""	""	"RCR14473"	"HMR_5171"	"HMR_5171"	""	""	""	0
 "MAR05172"	""	""	"HMR_5172"	"r1402"	""	""	""	"RCR14474"	"HMR_5172;r1402"	"HMR_5172"	""	""	""	0
-"MAR05173"	""	""	"HMR_5173"	""	""	""	""	"RCR14475"	"HMR_5173"	"HMR_5173"	""	""	""	0
 "MAR05174"	""	""	"HMR_5174"	""	""	""	""	"RCR14476"	"HMR_5174"	"HMR_5174"	""	""	""	0
 "MAR07282"	""	""	"HMR_7282"	""	""	""	""	"RCR11617"	""	"HMR_7282"	""	""	""	0
 "MAR07616"	""	""	"HMR_7616"	""	""	""	""	"RCR10348"	"HMR_7616"	"HMR_7616"	""	""	""	0
@@ -1078,7 +1068,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR05286"	""	""	"HMR_5286"	""	""	""	""	"RCR11641"	"HMR_5286"	"HMR_5286"	""	""	""	0
 "MAR05287"	""	""	"HMR_5287"	""	""	""	""	"RCR11642"	"HMR_5287"	"HMR_5287"	""	""	""	0
 "MAR05288"	""	""	"HMR_5288"	"r1403"	""	""	""	"RCR10594"	"r1403"	"HMR_5288"	""	""	""	0
-"MAR05289"	""	""	"HMR_5289"	""	""	""	""	"RCR14478"	"HMR_5289"	"HMR_5289"	""	""	""	0
 "MAR05290"	""	""	"HMR_5290"	""	""	""	""	"RCR11643"	"HMR_5290"	"HMR_5290"	""	""	""	0
 "MAR05291"	""	""	"HMR_5291"	""	""	""	""	"RCR11644"	"HMR_5291"	"HMR_5291"	""	""	""	0
 "MAR09817"	""	""	"HMR_9817"	""	""	""	""	"RCR10595"	"HMR_9817"	"HMR_9817"	""	""	""	0
@@ -1116,12 +1105,11 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR04458"	""	"R01325C"	"HMR_4458"	"r0317"	"R01325"	"MNXR105321;MNXR95386"	""	"RCR10106"	"r0317"	"HMR_4458"	"RHEA:10231"	"RHEA:10228"	""	0
 "MAR04465"	"HPYRRy"	"R01392C"	"HMR_4465"	"r0327"	"R01392"	"MNXR100336"	""	"RCR11666"	"HPYRRy"	"HMR_4465"	""	"RHEA:18657"	""	0
 "MAR04589"	""	"R01900C"	"HMR_4589"	"r0426"	"R01900"	"MNXR105342;MNXR95387"	""	"RCR10352"	"r0426"	"HMR_4589"	""	"RHEA:22144"	""	0
-"MAR04652"	"r0509"	"R02164C"	"HMR_4652"	"r0509"	"R02164"	"MNXR107340"	""	"RCR14481"	"r0509"	"HMR_4652"	""	"RHEA:13713"	""	0
+"MAR04652"	"r0509;SUCD1m"	"R02164C"	"HMR_4652;HMR_8743"	"r0509"	"R00408;R02164"	"MNXR107340;MNXR99636"	""	"RCR14481;RCR11674"	"r0509;SUCD1m"	"HMR_4652;HMR_8743;MAR08743"	""	"RHEA:13713;RHEA:30343"	""	0
 "MAR06413"	""	"R03316M"	"HMR_6413"	"r0620"	"R03316"	"MNXR105357;MNXR108089"	""	"RCR11672"	"r0620"	"HMR_6413"	""	""	""	0
 "MAR06414"	""	"R02570C"	"HMR_6414"	"r0556"	"R02570"	"MNXR107585;MNXR95656"	""	"RCR14482"	"r0556"	"HMR_6414"	""	"RHEA:15213"	""	0
 "MAR07704"	"GLXO2p"	""	"HMR_7704"	""	"R00466"	"MNXR100305"	""	"RCR10605"	"GLXO2p"	"HMR_7704"	""	"RHEA:14837"	""	0
 "MAR07706"	"GLYCTO1p"	""	"HMR_7706"	""	"R00475"	"MNXR100338"	""	"RCR11673"	"GLYCTO1p"	"HMR_7706"	""	"RHEA:25311"	""	0
-"MAR08743"	"SUCD1m"	""	"HMR_8743"	""	"R00408"	"MNXR99636"	""	"RCR11674"	"SUCD1m"	"HMR_8743"	""	"RHEA:30343"	""	0
 "MAR08772"	"KHK2"	""	"HMR_8772"	""	""	"MNXR100937"	""	"RCR11675"	"KHK2"	"HMR_8772"	""	""	""	0
 "MAR08773"	"FBP"	""	"HMR_8773"	""	"R01785"	"MNXR99465"	""	"RCR14483"	"FBA4"	"HMR_8773"	""	""	""	0
 "MAR08774"	"HPYRDC"	""	"HMR_8774"	""	"R01393"	"MNXR100700"	""	"RCR11676"	"HPYRDC"	"HMR_8774"	""	"RHEA:20561"	""	0
@@ -1292,7 +1280,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR02179"	""	"R04543C"	"HMR_2179"	"r0696"	"R04543"	"MNXR94946"	""	"RCR11798"	"r0696"	"HMR_2179"	""	""	""	0
 "MAR02180"	""	"R04544C"	"HMR_2180"	"r0697"	"R04544"	"MNXR94881"	""	"RCR11799"	"r0697"	"HMR_2180"	""	""	""	0
 "MAR02181"	""	"R04970C"	"HMR_2181"	"r0773"	"R04970"	"MNXR109259"	""	"RCR11800"	"r0773"	"HMR_2181"	"RHEA:41913"	"RHEA:41912"	""	0
-"MAR04156"	"ACCOAC"	"R00742C"	"HMR_4156"	"r0184"	"R00742"	"MNXR95219"	""	"RCR10617"	"ACCOAC"	"HMR_4156"	"RHEA:11309"	"RHEA:11308"	""	0
 "MAR04295"	"ACCOACrm"	"R00742C"	"HMR_4295"	"r0185"	"R00742"	"MNXR95219"	""	"RCR11801"	"ACCOACm"	"HMR_4295"	"RHEA:11309"	"RHEA:11308"	""	0
 "MAR02227"	""	""	"HMR_2227"	""	""	""	""	"RCR10098"	"HMR_2227"	"HMR_2227"	""	""	""	0
 "MAR02228"	""	""	"HMR_2228"	""	""	""	""	"RCR11802"	"HMR_2228"	"HMR_2228"	""	""	""	0
@@ -1518,7 +1505,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR02395"	""	""	"HMR_2395"	""	""	""	""	"RCR12032"	"HMR_2395"	"HMR_2395"	""	""	""	0
 "MAR02397"	""	"RE3154C"	"HMR_2397"	""	""	"MNXR103810"	""	"RCR12033"	"RE3154C"	"HMR_2397"	""	""	""	0
 "MAR02399"	""	"RE3155C"	"HMR_2399"	""	""	"MNXR103811"	""	"RCR12034"	"RE3155C"	"HMR_2399"	""	""	""	0
-"MAR02401"	""	"RE3150C"	"HMR_2401"	""	""	"MNXR103806"	""	"RCR12035"	""	"HMR_2401"	""	""	""	0
+"MAR02401"	"RE3150C"	"RE3150C"	"HMR_2401"	""	""	"MNXR103806"	""	"RCR12035"	"RE3150C"	"HMR_2401;RE3150C;MAR03441"	""	""	""	0
 "MAR02403"	""	""	"HMR_2403"	""	""	""	""	"RCR12036"	"HMR_2403"	"HMR_2403"	""	""	""	0
 "MAR02408"	""	"RE3157X"	"HMR_2408"	""	""	""	""	"RCR12037"	"RE3157X"	"HMR_2408"	""	""	""	0
 "MAR02409"	""	"RE3159X"	"HMR_2409"	""	""	""	""	"RCR12038"	"RE3159X"	"HMR_2409"	""	""	""	0
@@ -1563,7 +1550,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR00931"	""	"RE3650C"	"HMR_0931"	""	""	""	""	"RCR12080"	"HMR_0931"	"HMR_0931"	""	""	""	0
 "MAR00932"	""	"RE3646C"	"HMR_0932"	""	""	""	""	"RCR12081"	"HMR_0932"	"HMR_0932"	""	""	""	0
 "MAR00933"	""	"RE3648C"	"HMR_0933"	""	""	""	""	"RCR12082"	"HMR_0933"	"HMR_0933"	""	""	""	0
-"MAR00934"	""	"RE3651C"	"HMR_0934"	""	""	""	""	"RCR12083"	""	"HMR_0934"	""	""	""	0
+"MAR00934"	""	"R07041C;RE3651C"	"HMR_0934;HMR_0941"	""	"R07041"	"MNXR110751"	""	"RCR12083;RCR12090"	""	"HMR_0934;HMR_0941;MAR00941"	""	""	""	0
 "MAR00935"	""	"RE3647C"	"HMR_0935"	""	""	""	""	"RCR12084"	"HMR_0935"	"HMR_0935"	""	""	""	0
 "MAR00936"	""	"RE3649C"	"HMR_0936"	""	""	""	""	"RCR12085"	"HMR_0936"	"HMR_0936"	""	""	""	0
 "MAR00937"	""	"R07054C"	"HMR_0937"	""	"R07054"	"MNXR110764"	""	"RCR12086"	"HMR_0937"	"HMR_0937"	""	""	""	0
@@ -1783,7 +1770,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR02591"	"CSNATr"	"R02396C"	"HMR_2591"	"r0534"	"R02396"	"MNXR96926"	""	"RCR12360"	"CSNATr"	"HMR_2591"	""	"RHEA:21136"	""	0
 "MAR02594"	"C30CPT1"	""	"HMR_2594"	"r1396"	""	""	""	"RCR12361"	"C30CPT1"	"HMR_2594"	""	""	""	0
 "MAR02599"	""	"R01923X"	"HMR_2599"	"r0431"	"R01923"	"MNXR105343;MNXR107232"	""	"RCR12362"	"r0431"	"HMR_2599"	""	"RHEA:12661"	""	0
-"MAR02602"	"HMR_2602"	""	"HMR_2602"	""	""	""	""	"RCR12363"	"HMR_2602"	"HMR_2602"	""	""	""	0
+"MAR02602"	"C120CPT1;HMR_2602"	""	"HMR_2602"	""	""	""	""	"RCR12363"	"C120CPT1;HMR_2602"	"C120CPT1;HMR_2602;MAR04506"	""	""	""	0
 "MAR02605"	""	""	"HMR_2605"	""	""	""	""	"RCR12364"	"HMR_2605"	"HMR_2605"	""	""	""	0
 "MAR02608"	"HMR_2608"	""	"HMR_2608"	""	""	""	""	"RCR12365"	"HMR_2608"	"HMR_2608"	""	""	""	0
 "MAR02611"	"HMR_2611"	""	"HMR_2611"	""	""	""	""	"RCR12366"	"HMR_2611"	"HMR_2611"	""	""	""	0
@@ -2091,7 +2078,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR00002"	""	""	"HMR_0002"	""	"R02250"	""	""	"RCR30274"	"HMR_0002"	"HMR_0002"	""	""	""	0
 "MAR00003"	""	""	"HMR_0003"	""	"R02687"	""	""	"RCR30275"	"HMR_0003"	"HMR_0003"	""	""	""	0
 "MAR00005"	""	""	"HMR_0005"	""	"R01351"	""	""	"RCR12493"	"HMR_0005"	"HMR_0005"	""	"RHEA:34019"	""	0
-"MAR00449"	""	""	"HMR_0449"	""	"R00848"	"MNXR99875"	"R-HSA-188467"	"RCR12494"	"GLYC3PFADm"	"HMR_0449"	""	"RHEA:31283"	""	0
+"MAR00449"	""	""	"HMR_0449;HMR_0483"	"r0205"	"R00848;R00849"	"MNXR99875;MNXR106713"	"R-HSA-188467"	"RCR12494;RCR21050"	"GLYC3PFADm;r0205"	"HMR_0449;HMR_0483"	""	"RHEA:31283;RHEA:18977"	""	0
 "MAR00604"	"DAGK_hs"	""	"HMR_0604"	""	"R02240"	""	""	"RCR14512"	"DAGK_hs"	"HMR_0604"	""	"RHEA:10272"	""	0
 "MAR00605"	""	""	"HMR_0605"	"r1223"	"R02251"	""	""	"RCR12495"	"HMR_0605"	"HMR_0605"	""	"RHEA:10868"	""	0
 "MAR00665"	""	""	"HMR_0665"	"r1224"	"R02250"	""	""	"RCR14513"	"HMR_0665"	"HMR_0665"	""	""	""	0
@@ -2189,11 +2176,9 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR03352"	""	""	"HMR_3352"	""	""	""	""	"RCR12573"	"HMR_3352"	"HMR_3352"	""	""	""	0
 "MAR03353"	""	""	"HMR_3353"	""	""	""	""	"RCR12574"	"HMR_3353"	"HMR_3353"	""	""	""	0
 "MAR03355"	"DCIm"	""	"HMR_3355"	""	"R04100"	"MNXR97183"	""	"RCR12575"	"FAOXC121x"	"HMR_3355"	"RHEA:23719"	"RHEA:23716"	""	0
-"MAR03364"	""	"RE2913X"	"HMR_3364"	""	""	""	""	"RCR12576"	""	"HMR_3364"	""	""	""	0
 "MAR03365"	""	"RE2919X"	"HMR_3365"	""	""	""	""	"RCR12577"	"RE2919X"	"HMR_3365"	""	""	""	0
 "MAR03367"	""	"RE2908X"	"HMR_3367"	""	""	""	""	"RCR12578"	"RE2908X"	"HMR_3367"	""	""	""	0
 "MAR03368"	""	"RE2916X"	"HMR_3368"	""	""	""	""	"RCR12579"	"RE2916X"	"HMR_3368"	""	""	""	0
-"MAR03369"	""	"RE2914X"	"HMR_3369"	""	""	""	""	"RCR12580"	""	"HMR_3369"	""	""	""	0
 "MAR03370"	""	"RE2920X"	"HMR_3370"	""	""	""	""	"RCR12581"	"RE2920X"	"HMR_3370"	""	""	""	0
 "MAR03372"	""	"RE2909X"	"HMR_3372"	""	""	""	""	"RCR12582"	"RE2909X"	"HMR_3372"	""	""	""	0
 "MAR03373"	""	"RE2917X"	"HMR_3373"	""	""	""	""	"RCR12583"	"RE2917X"	"HMR_3373"	""	""	""	0
@@ -2215,16 +2200,13 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR03513"	""	"RE3092X"	"HMR_3513"	""	""	""	""	"RCR12603"	"RE3092X"	"HMR_3513"	""	""	""	0
 "MAR03514"	""	"RE3093X"	"HMR_3514"	""	""	""	""	"RCR12604"	"RE3093X"	"HMR_3514"	""	""	""	0
 "MAR03515"	""	"RE3090X"	"HMR_3515"	""	""	""	""	"RCR12605"	"RE3090X"	"HMR_3515"	""	""	""	0
-"MAR03517"	""	"RT0781"	"HMR_3517"	""	""	""	""	"RCR20504"	""	"HMR_3517"	""	""	""	0
-"MAR03301"	""	"RE1516X"	"HMR_3301"	""	""	""	""	"RCR12606"	""	"HMR_3301"	""	""	""	0
+"MAR03517"	"SCP22x"	"RT0781"	"HMR_3517"	""	""	"MNXR104294"	""	"RCR20504"	"SCP22x"	"HMR_3517;SCP22x;MAR01709"	""	""	""	0
 "MAR03302"	""	"RE1523X"	"HMR_3302"	""	""	""	""	"RCR12607"	"RE1523X"	"HMR_3302"	""	""	""	0
 "MAR03304"	""	"RE0512X"	"HMR_3304"	""	""	""	""	"RCR12608"	"RE0512X"	"HMR_3304"	""	""	""	0
 "MAR03305"	""	"RE1531X"	"HMR_3305"	""	""	""	""	"RCR12609"	"RE1531X"	"HMR_3305"	""	""	""	0
-"MAR03306"	""	"RE1517X"	"HMR_3306"	""	""	""	""	"RCR12610"	""	"HMR_3306"	""	""	""	0
 "MAR03307"	""	"RE1522X"	"HMR_3307"	""	""	""	""	"RCR12611"	"RE1522X"	"HMR_3307"	""	""	""	0
 "MAR03309"	""	"RE1525X"	"HMR_3309"	""	""	""	""	"RCR12612"	"RE1525X"	"HMR_3309"	""	""	""	0
 "MAR03310"	""	"RE1532X"	"HMR_3310"	""	""	""	""	"RCR12613"	"RE1532X"	"HMR_3310"	""	""	""	0
-"MAR03311"	""	"RE1518X"	"HMR_3311"	""	""	""	""	"RCR14519"	""	"HMR_3311"	""	""	""	0
 "MAR03312"	""	"RE1521X"	"HMR_3312"	""	""	""	""	"RCR14520"	"RE1521X"	"HMR_3312"	""	""	""	0
 "MAR03314"	""	"RE1526X"	"HMR_3314"	""	""	""	""	"RCR12614"	"RE1526X"	"HMR_3314"	""	""	""	0
 "MAR03315"	""	"RE1533X"	"HMR_3315"	""	""	""	""	"RCR12615"	"RE1533X"	"HMR_3315"	""	""	""	0
@@ -2246,27 +2228,27 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR03116"	""	""	"HMR_3116"	""	"R07760"	""	""	"RCR12630"	"HMR_3116"	"HMR_3116"	"RHEA:35349"	"RHEA:35347"	""	0
 "MAR03117"	""	""	"HMR_3117"	""	""	""	""	"RCR12631"	"HMR_3117"	"HMR_3117"	"RHEA:35276"	"RHEA:35275"	""	0
 "MAR03118"	""	""	"HMR_3118"	""	""	""	""	"RCR12632"	"HMR_3118"	"HMR_3118"	""	""	""	0
-"MAR03121"	""	""	"HMR_3121"	""	"R01279"	"MNXR125070"	"R-HSA-77299"	"RCR12633"	"HMR_3121"	"HMR_3121"	""	"RHEA:30747"	""	0
+"MAR03121"	"r0310"	""	"HMR_3121"	""	"R01279"	"MNXR125070"	"R-HSA-77299"	"RCR12633"	"HMR_3121;r0310"	"HMR_3121;r0310;MAR02035"	""	"RHEA:30747"	""	0
 "MAR03122"	""	"R04738X"	"HMR_3122"	"r0716"	"R04738"	"MNXR105372;MNXR97892"	""	"RCR12634"	"r0716"	"HMR_3122"	""	"RHEA:31163"	""	0
 "MAR03123"	""	"R04737X"	"HMR_3123"	"r0714"	"R04737"	"MNXR100548;MNXR105371"	""	"RCR12635"	"r0714"	"HMR_3123"	""	"RHEA:31159"	""	0
 "MAR03125"	""	"R03991X"	"HMR_3125"	"r0653"	"R03991"	"MNXR95203"	""	"RCR12636"	"r0653"	"HMR_3125"	""	"RHEA:18161"	""	0
-"MAR03128"	""	""	"HMR_3128"	""	"R03990"	"MNXR95300"	"R-HSA-77274"	"RCR12637"	"HMR_3128"	"HMR_3128"	""	"RHEA:28358"	""	0
+"MAR03128"	"r1449"	""	"HMR_3128"	""	"R03990"	"MNXR95300"	"R-HSA-77274"	"RCR12637"	"HMR_3128;r1449"	"HMR_3128;r1449;MAR02370"	""	"RHEA:28358"	""	0
 "MAR03129"	""	"R04740X"	"HMR_3129"	"r0720"	"R04740"	"MNXR105373;MNXR97891"	""	"RCR12638"	"r0720"	"HMR_3129"	""	"RHEA:31171"	""	0
 "MAR03130"	""	"R04739X"	"HMR_3130"	"r0718"	"R04739"	"MNXR100547"	""	"RCR12639"	"r0718"	"HMR_3130"	""	"RHEA:31167"	""	0
 "MAR03132"	""	"R03858X"	"HMR_3132"	"r0639"	"R03858"	"MNXR95201"	""	"RCR12640"	"r0639"	"HMR_3132"	""	"RHEA:31091"	""	0
-"MAR03135"	""	""	"HMR_3135"	""	"R03857"	"MNXR95299"	"R-HSA-77263"	"RCR12641"	"HMR_3135"	"HMR_3135"	""	"RHEA:31039"	""	0
-"MAR03136"	""	"R04170X"	"HMR_3136"	"r0660"	"R04170"	"MNXR97890"	""	"RCR12642"	"r0660"	"HMR_3136"	""	"RHEA:31075"	""	0
+"MAR03135"	"r1447"	""	"HMR_3135"	""	"R03857"	"MNXR95299"	"R-HSA-77263"	"RCR12641"	"HMR_3135;r1447"	"HMR_3135;r1447;MAR02367"	""	"RHEA:31039"	""	0
+"MAR03136"	"r1446"	"R04170X"	"HMR_3136"	"r0660"	"R04170"	"MNXR97890"	""	"RCR12642"	"r0660;r1446"	"HMR_3136;r1446;MAR02366"	""	"RHEA:31075"	""	0
 "MAR03137"	""	"R04741X"	"HMR_3137"	"r0722"	"R04741"	"MNXR100546"	""	"RCR12643"	"r0722"	"HMR_3137"	""	"RHEA:31179"	""	0
 "MAR03139"	""	"R04742X"	"HMR_3139"	"r0724"	"R04742"	"MNXR95199;MNXR95200"	""	"RCR12644"	"r0724"	"HMR_3139"	"RHEA:31185"	"RHEA:31183"	""	0
-"MAR03142"	""	""	"HMR_3142"	""	"R04754"	"MNXR109095"	"R-HSA-77345"	"RCR12645"	"HMR_3142"	"HMR_3142"	""	"RHEA:28354"	""	0
+"MAR03142"	"r1451"	""	"HMR_3142"	""	"R04754"	"MNXR109095"	"R-HSA-77345"	"RCR12645"	"HMR_3142;r1451"	"HMR_3142;r1451;MAR02373"	""	"RHEA:28354"	""	0
 "MAR03143"	""	"R04744X"	"HMR_3143"	"r0728"	"R04744"	"MNXR97889"	""	"RCR12646"	"r0728"	"HMR_3143"	""	"RHEA:31191"	""	0
 "MAR03144"	""	"R04743X"	"HMR_3144"	"r0726"	"R04743"	"MNXR100545"	""	"RCR12647"	"r0726"	"HMR_3144"	""	"RHEA:31187"	""	0
 "MAR03146"	""	"R03778X"	"HMR_3146"	"r0634"	"R03778"	"MNXR95198"	""	"RCR12648"	"r0634"	"HMR_3146"	"RHEA:31089"	"RHEA:31087"	""	0
-"MAR03149"	""	""	"HMR_3149"	""	"R03777"	"MNXR95304"	"R-HSA-77338"	"RCR12649"	"HMR_3149"	"HMR_3149"	""	"RHEA:30943"	""	0
+"MAR03149"	"r1448"	""	"HMR_3149"	""	"R03777"	"MNXR95304"	"R-HSA-77338"	"RCR12649"	"HMR_3149;r1448"	"HMR_3149;r1448;MAR02369"	""	"RHEA:30943"	""	0
 "MAR03150"	""	"R04746M"	"HMR_3150"	"r0731"	"R04746"	"MNXR97888"	""	"RCR12650"	"r0731"	"HMR_3150"	""	"RHEA:31199"	""	0
 "MAR03151"	""	"R04745M"	"HMR_3151"	"r0730"	"R04745"	"MNXR100544"	""	"RCR12651"	"r0730"	"HMR_3151"	""	"RHEA:31195"	""	0
 "MAR03153"	""	"R04747M"	"HMR_3153"	"r0732"	"R04747"	"MNXR109092"	""	"RCR12652"	"r0732"	"HMR_3153"	"RHEA:31205"	"RHEA:31203"	""	0
-"MAR03156"	""	""	"HMR_3156"	""	"R04751"	"MNXR109093"	"R-HSA-77327"	"RCR12653"	"HMR_3156"	"HMR_3156"	""	"RHEA:31207"	""	0
+"MAR03156"	"r1450"	""	"HMR_3156"	""	"R04751"	"MNXR109093"	"R-HSA-77327"	"RCR12653"	"HMR_3156;r1450"	"HMR_3156;r1450;MAR02372"	""	"RHEA:31207"	""	0
 "MAR03157"	""	"R04749M"	"HMR_3157"	"r0734"	"R04749"	"MNXR97886"	""	"RCR12654"	"r0734"	"HMR_3157"	""	"RHEA:30547"	""	0
 "MAR03158"	""	"R04748M"	"HMR_3158"	"r0733"	"R04748"	"MNXR100543"	"R-HSA-77323"	"RCR12655"	"r0733"	"HMR_3158"	""	"RHEA:31143"	""	0
 "MAR03160"	""	"R01177M"	"HMR_3160"	"r0287"	"R01177"	"MNXR95196"	"R-HSA-77321"	"RCR12656"	"r0287"	"HMR_3160"	""	"RHEA:31111"	""	0
@@ -2441,8 +2423,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR07167"	""	""	"HMR_7167"	""	"R09845"	"MNXR113246"	""	"RCR12825"	"HMR_7167"	"HMR_7167"	""	""	""	0
 "MAR07168"	""	""	"HMR_7168"	""	"R04496"	"MNXR108926"	""	"RCR12826"	"HMR_7168"	"HMR_7168"	""	"RHEA:21672"	""	0
 "MAR07169"	""	""	"HMR_7169"	""	"R09847"	"MNXR113248"	""	"RCR12827"	"HMR_7169"	"HMR_7169"	""	""	""	0
-"MAR01644"	""	"RE3248M"	"HMR_1644"	""	"R04813"	""	""	"RCR12830"	"HMR_1644"	"HMR_1644"	""	"RHEA:18933"	""	0
-"MAR01651"	""	"RE3250M"	"HMR_1651"	""	"R04812"	""	""	"RCR12831"	"HMR_1651"	"HMR_1651"	""	""	""	0
 "MAR01924"	""	""	"HMR_1924"	""	""	""	"R-HSA-196126"	"RCR12832"	""	"HMR_1924"	""	""	""	0
 "MAR01926"	""	""	"HMR_1926"	""	""	""	"R-HSA-196086"	"RCR12833"	""	"HMR_1926"	""	""	""	0
 "MAR01927"	""	""	"HMR_1927"	""	"R02723"	"MNXR107692;MNXR124738"	"R-HSA-193054"	"RCR12834"	"HMR_1927"	"HMR_1927"	""	"RHEA:34335"	""	0
@@ -2904,8 +2884,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR00478"	""	""	"HMR_0478"	""	"R00844"	"MNXR99876"	"R-HSA-75889"	"RCR14575"	"HMR_0478"	"HMR_0478"	"RHEA:11098"	"RHEA:11096"	""	0
 "MAR00479"	"G3PD1"	"R00842C"	"HMR_0479"	"r0201"	"R00842"	"MNXR99876"	""	"RCR14576"	"G3PD1"	"HMR_0479"	""	"RHEA:11092"	""	0
 "MAR00481"	""	"R00842C"	"HMR_0481"	"r0202"	"R00842"	"MNXR99876"	""	"RCR14577"	"r0202"	"HMR_0481"	""	"RHEA:11092"	""	0
-"MAR00483"	""	""	"HMR_0483"	"r0205"	"R00849"	"MNXR106713"	""	"RCR21050"	"r0205"	"HMR_0483"	""	"RHEA:18977"	""	0
-"MAR00482"	"G3PD2m"	"R00848C"	"HMR_0482"	""	"R00848"	"MNXR99875"	""	"RCR14578"	"HMR_0482"	"HMR_0482"	""	"RHEA:31283"	""	0
+"MAR00482"	"G3PD2m"	"R00848C"	"HMR_0482;HMR_0483"	"r0205"	"R00848;R00849"	"MNXR99875;MNXR106713"	""	"RCR14578;RCR21050"	"HMR_0482;r0205"	"HMR_0482;HMR_0483"	""	"RHEA:31283;RHEA:18977"	""	0
 "MAR00579"	""	""	"HMR_0579"	"r1307"	"R00851"	""	""	"RCR13155"	"HMR_0579"	"HMR_0579"	""	"RHEA:15325"	""	0
 "MAR00580"	""	""	"HMR_0580"	"r1308"	"R02241"	""	""	"RCR13156"	"HMR_0580"	"HMR_0580"	""	"RHEA:19709"	""	0
 "MAR00581"	""	""	"HMR_0581"	"r1309"	""	""	""	"RCR10854"	"HMR_0581"	"HMR_0581"	""	""	""	0
@@ -3129,13 +3108,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR07610"	""	""	"HMR_7610"	""	"R04321"	"MNXR108810"	""	"RCR14616"	"HMR_7610"	"HMR_7610"	""	"RHEA:36183"	""	0
 "MAR07614"	""	""	"HMR_7614"	""	"R03438"	"MNXR108170"	""	"RCR10262"	"HMR_7614"	"HMR_7614"	""	"RHEA:23992"	""	0
 "MAR07615"	""	""	"HMR_7615"	""	"R07387"	"MNXR111044"	""	"RCR13366"	"HMR_7615"	"HMR_7615"	""	"RHEA:36231"	""	0
-"MAR00024"	""	""	"HMR_0024"	""	""	""	""	"RCR13367"	"HMR_0024"	"HMR_0024"	""	""	""	0
-"MAR00025"	""	""	"HMR_0025"	""	""	""	""	"RCR20226"	"HMR_0025"	"HMR_0025"	""	""	""	0
-"MAR00026"	""	""	"HMR_0026"	""	""	""	""	"RCR21051"	"HMR_0026"	"HMR_0026"	""	""	""	0
-"MAR00027"	""	""	"HMR_0027"	""	""	""	""	"RCR21052"	"HMR_0027"	"HMR_0027"	""	""	""	0
-"MAR00028"	""	""	"HMR_0028"	""	""	""	""	"RCR21053"	"HMR_0028"	"HMR_0028"	""	""	""	0
-"MAR00029"	""	""	"HMR_0029"	""	""	""	""	"RCR40953"	"HMR_0029"	"HMR_0029"	""	""	""	0
-"MAR00030"	""	""	"HMR_0030"	""	""	""	""	"RCR20227"	"HMR_0030"	"HMR_0030"	""	""	""	0
 "MAR07200"	"XYLTer"	""	"HMR_7200"	""	"R05925"	"MNXR105263;MNXR109949"	""	"RCR13368"	"XYLTer"	"HMR_7200"	""	"RHEA:50192"	""	0
 "MAR07202"	"GALTg"	""	"HMR_7202"	""	"R05926"	"MNXR100017;MNXR109950"	""	"RCR14617"	"GALTg"	"HMR_7202"	""	"RHEA:15297"	""	0
 "MAR07203"	"GALT2g"	""	"HMR_7203"	""	"R05927"	"MNXR100016"	""	"RCR13369"	"GALT2g"	"HMR_7203"	""	"RHEA:11780"	""	0
@@ -3406,15 +3378,10 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR01622"	""	""	"HMR_1622"	"r2517"	""	"MNXR106326"	""	"RCR20231"	"r2517"	"HMR_1622"	""	""	""	0
 "MAR01623"	"HMR_1623"	""	"HMR_1623"	""	""	""	""	"RCR20232"	"HMR_1623"	"HMR_1623"	""	""	""	0
 "MAR01632"	""	"RE2624X"	"HMR_1632"	""	"R08734"	"MNXR112240"	"R-HSA-192056"	"RCR10915"	"AMACRp;RE2624X"	"HMR_1632"	"RHEA:40456"	"RHEA:40455"	""	0
-"MAR01635"	""	"RE2624M"	"HMR_1635"	""	"R08734"	"MNXR112240"	"R-HSA-192056"	"RCR13606"	"HMR_1635;RE2624M"	"HMR_1635"	"RHEA:40456"	"RHEA:40455"	""	0
-"MAR01637"	""	"RE3247M"	"HMR_1637"	"r0706"	""	"MNXR105369;MNXR124225"	"R-HSA-192335"	"RCR13607"	"HMR_1637;RE3247M"	"HMR_1637"	""	""	""	0
-"MAR01638"	"ACOX2x"	""	"HMR_1638"	""	""	""	""	"RCR10916"	"ACOX2x"	"HMR_1638"	""	""	""	0
-"MAR01639"	""	"RE3247X"	"HMR_1639"	"r0706"	""	"MNXR105369;MNXR124225"	"R-HSA-192335"	"RCR10917"	"RE3247X;r0706"	"HMR_1639"	""	""	""	0
+"MAR01638"	"ACOX2x"	"RE3247X"	"HMR_1638;HMR_1639"	"r0706"	""	"MNXR105369;MNXR124225"	"R-HSA-192335"	"RCR10916;RCR10917"	"ACOX2x;RE3247X;r0706"	"HMR_1638;HMR_1639;MAR01639"	""	""	""	0
 "MAR01642"	""	""	"HMR_1642"	"r0744"	"R04813"	"MNXR105377;MNXR109137;MNXR115598"	"R-HSA-192331"	"RCR10918"	"r0744"	"HMR_1642"	""	"RHEA:18933"	""	0
 "MAR01646"	""	""	"HMR_1646"	"r0743"	"R04812"	"MNXR105376;MNXR109136"	""	"RCR13608"	"r0743"	"HMR_1646"	""	""	""	0
 "MAR01652"	"SCPx"	"R03719X"	"HMR_1652"	"r0628"	"R03719"	"MNXR104297;MNXR108369"	""	"RCR13609"	"SCPx"	"HMR_1652"	""	"RHEA:16865"	""	0
-"MAR01653"	"SCPx"	"R03719X"	"HMR_1653"	"r0628"	"R03719"	"MNXR104297;MNXR108369"	""	"RCR13610"	"HMR_1653"	"HMR_1653"	""	"RHEA:16865"	""	0
-"MAR01656"	""	""	"HMR_1656"	"r0990"	""	"MNXR105412"	""	"RCR20134"	"r0990"	"HMR_1656"	""	""	""	0
 "MAR01659"	""	""	"HMR_1659"	"r2501"	""	"MNXR106313"	""	"RCR20234"	"r2501"	"HMR_1659"	""	""	"3.A.1.203.3"	0
 "MAR01673"	"AKR1D"	"R04817C"	"HMR_1673"	"r0745"	"R04817"	"MNXR109138;MNXR124222;MNXR95670"	"R-HSA-192033"	"RCR13614"	"AKR1D"	"HMR_1673"	"RHEA:46641"	"RHEA:46640"	""	0
 "MAR01676"	""	"R04819C"	"HMR_1676"	"r0747"	"R04819"	"MNXR105378;MNXR109140"	"R-HSA-192160"	"RCR13615"	"r0747"	"HMR_1676"	""	""	""	0
@@ -3441,7 +3408,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR01710"	""	""	"HMR_1710"	""	"R04811"	"MNXR109135"	"R-HSA-193533"	"RCR13631"	"HMR_1710"	"HMR_1710"	""	""	""	0
 "MAR01717"	""	""	"HMR_1717"	"r1019"	""	"MNXR105425"	""	"RCR20161"	"r1019"	"HMR_1717"	""	""	""	0
 "MAR01725"	""	""	"HMR_1725"	"r1018"	""	"MNXR105425"	""	"RCR20519"	"r1018"	"HMR_1725"	""	""	""	0
-"MAR01729"	""	""	"HMR_1729"	""	""	""	""	"RCR10395"	""	"HMR_1729"	""	""	""	0
+"MAR01729"	"HC02220c"	""	"HMR_1729"	""	""	""	""	"RCR10395"	"HC02220c"	"HC02220c;HMR_1729;MAR10447"	""	""	""	0
 "MAR01738"	""	""	"HMR_1738"	""	""	"MNXR124761"	"R-HSA-193789"	"RCR13636"	"HMR_1738"	"HMR_1738"	"RHEA:47200"	"RHEA:47200"	""	0
 "MAR01740"	""	""	"HMR_1740"	""	""	"MNXR124230"	"R-HSA-193755"	"RCR13638"	"HMR_1740"	"HMR_1740"	""	""	""	0
 "MAR01741"	""	""	"HMR_1741"	""	""	"MNXR124229"	"R-HSA-193746"	"RCR13639"	"HMR_1741"	"HMR_1741"	""	""	""	0
@@ -3506,14 +3473,14 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR08065"	"LCYSTCBOXL"	""	"HMR_8065"	""	"R01682"	"MNXR101032"	""	"RCR13689"	"LCYSTCBOXL"	"HMR_8065"	"RHEA:25222"	"RHEA:25221"	""	0
 "MAR08759"	"HYPTROX"	""	"HMR_8759"	""	""	"MNXR100764"	""	"RCR14644"	"HYPTROX"	"HMR_8759"	""	""	""	0
 "MAR01850"	""	""	"HMR_1850"	"r0970"	""	"MNXR105409"	""	"RCR20238"	"r0970"	"HMR_1850"	""	""	""	0
-"MAR01853"	""	""	"HMR_1853"	"r0993"	""	"MNXR105414"	""	"RCR40170"	""	"HMR_1853"	""	""	"3.A.1.208.2"	0
-"MAR01854"	""	""	"HMR_1854"	"r0994"	""	"MNXR105415"	""	"RCR20528"	""	"HMR_1854"	""	""	""	0
+"MAR01853"	"r0993"	""	"HMR_1853"	"r0993"	""	"MNXR105414"	""	"RCR40170"	"r0993"	"HMR_1853;r0993;MAR02276"	""	""	"3.A.1.208.2"	0
+"MAR01854"	"r0994"	""	"HMR_1854"	"r0994"	""	"MNXR105415"	""	"RCR20528"	"r0994"	"HMR_1854;r0994;MAR02277"	""	""	""	0
 "MAR01857"	""	""	"HMR_1857"	"r1017"	""	"MNXR104744"	""	"RCR40318"	""	"HMR_1857"	""	""	""	0
 "MAR01859"	""	""	"HMR_1859"	"r1027"	""	"MNXR105430"	""	"RCR40172"	"r1027"	"HMR_1859"	""	""	""	0
 "MAR01861"	""	""	"HMR_1861"	"r1029"	""	"MNXR105431"	""	"RCR40147"	""	"HMR_1861"	""	""	""	0
 "MAR01862"	""	""	"HMR_1862"	"r1163"	""	""	""	"RCR40955"	"r1163"	"HMR_1862"	""	""	"2.A.28.1.1"	0
 "MAR01863"	"GCHOLAt2"	""	"HMR_1863"	"r1494"	""	"MNXR100071"	""	"RCR40956"	"GCHOLAt2"	"HMR_1863"	""	""	"2.A.28.1.1"	0
-"MAR01864"	""	""	"HMR_1864"	"r1495"	""	"MNXR105478"	""	"RCR40957"	""	"HMR_1864"	""	""	"2.A.28.1.1"	0
+"MAR01864"	"r1495"	""	"HMR_1864"	"r1495"	""	"MNXR105478"	""	"RCR40957"	"r1495"	"HMR_1864;r1495;MAR02384"	""	""	"2.A.28.1.1"	0
 "MAR01865"	"TCHOLAt2"	""	"HMR_1865"	"r1496"	""	"MNXR104743"	""	"RCR40958"	"TCHOLAt2"	"HMR_1865"	""	""	"2.A.28.1.1"	0
 "MAR01866"	""	""	"HMR_1866"	"r1497"	""	"MNXR105479"	""	"RCR40959"	"r1497"	"HMR_1866"	""	""	"2.A.28.1.1"	0
 "MAR01867"	""	""	"HMR_1867"	"r1498"	""	"MNXR105480"	""	"RCR40960"	"r1498"	"HMR_1867"	""	""	"2.A.28.1.1"	0
@@ -3532,9 +3499,9 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR01883"	""	""	"HMR_1883"	"r2154"	""	"MNXR106051"	""	"RCR40331"	"r2154"	"HMR_1883"	""	""	"2.A.60.1.14"	0
 "MAR01884"	""	""	"HMR_1884"	"r2155"	""	"MNXR106052"	""	"RCR40332"	"r2155"	"HMR_1884"	""	""	"2.A.60.1.14"	0
 "MAR01885"	""	""	"HMR_1885"	"r2156"	""	"MNXR106053"	""	"RCR40333"	"r2156"	"HMR_1885"	""	""	"2.A.60.1.14"	0
-"MAR01886"	""	""	"HMR_1886"	"r2157"	""	"MNXR106054"	""	"RCR40334"	""	"HMR_1886"	""	""	"2.A.60.1.14"	0
-"MAR01887"	""	""	"HMR_1887"	"r2158"	""	"MNXR106055"	""	"RCR40335"	""	"HMR_1887"	""	""	"2.A.60.1.14"	0
-"MAR01888"	""	""	"HMR_1888"	"r2159"	""	"MNXR106056"	""	"RCR40336"	""	"HMR_1888"	""	""	"2.A.60.1.14"	0
+"MAR01886"	"r2157"	""	"HMR_1886"	"r2157"	""	"MNXR106054"	""	"RCR40334"	"r2157"	"HMR_1886;r2157;MAR02390"	""	""	"2.A.60.1.14"	0
+"MAR01887"	"r2158"	""	"HMR_1887"	"r2158"	""	"MNXR106055"	""	"RCR40335"	"r2158"	"HMR_1887;r2158;MAR02392"	""	""	"2.A.60.1.14"	0
+"MAR01888"	"r2159"	""	"HMR_1888"	"r2159"	""	"MNXR106056"	""	"RCR40336"	"r2159"	"HMR_1888;r2159;MAR02394"	""	""	"2.A.60.1.14"	0
 "MAR01889"	""	""	"HMR_1889"	"r2160"	""	"MNXR106057"	""	"RCR40337"	"r2160"	"HMR_1889"	""	""	"2.A.60.1.14"	0
 "MAR01890"	""	""	"HMR_1890"	"r2161"	""	"MNXR106058"	""	"RCR40338"	"r2161"	"HMR_1890"	""	""	"2.A.60.1.14"	0
 "MAR01891"	""	""	"HMR_1891"	"r2162"	""	"MNXR106059"	""	"RCR40339"	"r2162"	"HMR_1891"	""	""	"2.A.60.1.14"	0
@@ -3798,8 +3765,8 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR07669"	"APOCF"	""	"HMR_7669"	""	""	"MNXR95887"	""	"RCR13841"	"APOCF"	"HMR_7669"	""	""	""	0
 "MAR07670"	"BTNPL"	""	"HMR_7670"	""	"R05145"	"MNXR109352;MNXR96332"	""	"RCR13842"	"BTNPL"	"HMR_7670"	""	"RHEA:59732"	""	0
 "MAR07671"	"APOC_LYS_BTNP"	""	"HMR_7671"	""	"R04869"	"MNXR109178"	""	"RCR13843"	"APOC_LYS_BTNP"	"HMR_7671"	""	""	""	0
-"MAR07672"	""	""	"HMR_7672"	""	"R04385"	"MNXR96330"	""	"RCR13844"	""	"HMR_7672"	""	"RHEA:13501"	""	0
-"MAR07673"	""	""	"HMR_7673"	""	"R04386"	"MNXR95220"	""	"RCR13845"	""	"HMR_7673"	""	"RHEA:54728"	""	0
+"MAR07672"	""	""	"HMR_7672"	""	"R04385"	"MNXR96330"	""	"RCR13844"	""	"HMR_7672;MAR04156"	""	"RHEA:13501"	""	0
+"MAR07673"	""	""	"HMR_7673"	""	"R04386"	"MNXR95220"	""	"RCR13845"	""	"HMR_7673;MAR01456"	""	"RHEA:54728"	""	0
 "MAR04160"	"GTPCI"	"R00424C"	"HMR_4160"	"r0117"	"R00424"	"MNXR100453"	""	"RCR13846"	"GTPCI"	"HMR_4160"	""	"RHEA:17473"	""	0
 "MAR04162"	"GTPCIn"	"R00424C"	"HMR_4162"	"r0118"	"R00424"	"MNXR100453"	""	"RCR14687"	"GTPCIn"	"HMR_4162"	""	"RHEA:17473"	""	0
 "MAR04163"	"PTHPS"	"R04286C"	"HMR_4163"	"r0674"	"R04286"	"MNXR103331"	""	"RCR10975"	"PTHPS"	"HMR_4163"	""	"RHEA:22048"	""	0
@@ -3863,7 +3830,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR08634"	"BILIRED"	""	"HMR_8634"	""	"R02393"	"MNXR96259"	""	"RCR13880"	"BILIRED"	"HMR_8634"	""	"RHEA:15793"	""	0
 "MAR09717"	""	""	"HMR_9717"	""	"R03684"	"MNXR108338"	""	"RCR14697"	"HMR_9717"	"HMR_9717"	""	""	""	0
 "MAR06630"	""	""	"HMR_6630"	""	"R08379"	"MNXR103440"	""	"RCR13881"	"RDH1a"	"HMR_6630"	""	"RHEA:25033"	""	0
-"MAR06631"	""	""	"HMR_6631"	""	"R02124"	"MNXR103439"	""	"RCR10422"	"RDH1"	"HMR_6631"	""	"RHEA:21284"	""	0
+"MAR06631"	"HMR_6633;RDH1;R_HMR_6633;R_RDH1;R_TRETINOLOR1;TRETINOLOR1"	""	"HMR_6631"	""	"R02124"	"MNXR103439;MNXR189842"	""	"RCR10422"	"RDH1"	"HMR_6631;MAR20002"	""	"RHEA:21284"	""	0
 "MAR06632"	""	""	"HMR_6632"	""	"R08379"	"MNXR103440"	""	"RCR13882"	"HMR_6632"	"HMR_6632"	""	"RHEA:25033"	""	0
 "MAR06633"	""	""	"HMR_6633"	""	"R02124"	"MNXR103439"	""	"RCR14698"	"HMR_6633"	"HMR_6633"	""	"RHEA:21284"	""	0
 "MAR06635"	""	""	"HMR_6635"	""	"R08387"	"MNXR111932"	""	"RCR10984"	"HMR_6635"	"HMR_6635"	""	""	""	0
@@ -4132,7 +4099,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR06536"	""	"RE2514C"	"HMR_6536"	""	""	"MNXR103688"	""	"RCR14123"	"RE2514C"	"HMR_6536"	""	""	""	0
 "MAR09569"	""	"R03024C"	"HMR_9569"	"r0587"	"R03024"	"MNXR105353;MNXR107896"	""	"RCR30521"	"r0587"	"HMR_9569"	""	"RHEA:21664"	""	0
 "MAR03955"	"HCO3E"	""	"HMR_3955"	""	"R10092"	"MNXR100482"	""	"RCR10229"	"H2CO3D"	"HMR_3955"	"RHEA:10750"	"RHEA:10748"	""	0
-"MAR03984"	"CATp"	""	"HMR_3984"	"r0012"	"R00009"	"MNXR96455"	""	"RCR11007"	"CATp"	"HMR_3984"	"RHEA:20310"	"RHEA:20309"	""	0
+"MAR03984"	"CAT;CATm;CATp;CATpp;CATr;R_CAT;R_CATm;R_CATp;R_CATpp;R_CATr"	""	"HMR_3984"	"r0012"	"R00009"	"MNXR96455"	""	"RCR11007"	"CATp"	"HMR_3984;MAR20066"	"RHEA:20310"	"RHEA:20309"	""	0
 "MAR04201"	"PRDX"	"R00602C"	"HMR_4201"	"r0162"	"R00602"	"MNXR103159"	""	"RCR14124"	"PRDX"	"HMR_4201"	"RHEA:30692"	"RHEA:30691"	""	0
 "MAR04202"	"ALCD1"	""	"HMR_4202"	""	"R00605"	"MNXR95708"	""	"RCR14125"	"ALCD1"	"HMR_4202"	"RHEA:19402"	"RHEA:19401"	""	0
 "MAR05127"	""	""	"HMR_5127"	"r1085"	""	""	""	"RCR14752"	""	"HMR_5127"	""	""	""	1
@@ -4355,7 +4322,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR00428"	""	""	"HMR_0428"	""	""	""	""	"RCR40104"	"HMR_0428"	"HMR_0428"	""	""	"4.C.1.1.5;4.C.1.1.8"	0
 "MAR00432"	""	""	"HMR_0432"	""	""	""	""	"RCR40105"	"HMR_0432"	"HMR_0432"	""	""	"4.C.1.1.5;4.C.1.1.8"	0
 "MAR00436"	""	""	"HMR_0436"	""	""	""	""	"RCR40106"	"HMR_0436"	"HMR_0436"	""	""	"4.C.1.1.5;4.C.1.1.8"	0
-"MAR00440"	""	""	"HMR_0440"	""	""	""	""	"RCR40410"	""	"HMR_0440"	""	""	""	0
+"MAR00440"	"PHYTt"	""	"HMR_0440"	""	""	"MNXR102660"	""	"RCR40410"	"PHYTt"	"HMR_0440;PHYTt;;MAR01617"	""	""	""	0
 "MAR00469"	""	""	"HMR_0469"	"r1509"	""	""	""	"RCR40966"	"HMR_0469"	"HMR_0469"	""	""	"3.A.1.201.3"	0
 "MAR00470"	"PCt"	""	"HMR_0470"	"r1511"	""	"MNXR102419"	""	"RCR40412"	"HMR_0470"	"HMR_0470"	""	""	"3.A.1.201.3"	0
 "MAR00476"	"PCt"	""	"HMR_0476"	"r1524"	""	"MNXR102419"	""	"RCR40211"	"PCt"	"HMR_0476"	""	""	"3.A.1.211.1"	0
@@ -5213,9 +5180,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR06139"	""	""	"HMR_6139"	"r2233"	""	"MNXR106130"	""	"RCR40592"	"r2233"	"HMR_6139"	""	""	"2.A.60.1.5"	0
 "MAR06140"	""	""	"HMR_6140"	"r2234"	""	"MNXR106131"	""	"RCR40593"	"r2234"	"HMR_6140"	""	""	"2.A.60.1.5"	0
 "MAR06141"	""	""	"HMR_6141"	"r2235"	""	"MNXR106132"	""	"RCR40594"	"r2235"	"HMR_6141"	""	""	"2.A.60.1.5"	0
-"MAR06142"	""	""	"HMR_6142"	"r2236"	""	"MNXR106133"	""	"RCR40595"	""	"HMR_6142"	""	""	"2.A.60.1.5"	0
-"MAR06143"	""	""	"HMR_6143"	"r2237"	""	"MNXR106134"	""	"RCR40596"	""	"HMR_6143"	""	""	"2.A.60.1.5"	0
-"MAR06144"	""	""	"HMR_6144"	"r2238"	""	"MNXR106135"	""	"RCR40597"	""	"HMR_6144"	""	""	"2.A.60.1.5"	0
 "MAR06145"	""	""	"HMR_6145"	"r2239"	""	"MNXR106136"	""	"RCR40598"	"r2239"	"HMR_6145"	""	""	"2.A.60.1.5"	0
 "MAR06146"	""	""	"HMR_6146"	"r2240"	""	"MNXR106137"	""	"RCR40599"	"r2240"	"HMR_6146"	""	""	"2.A.60.1.5"	0
 "MAR06147"	""	""	"HMR_6147"	"r2241"	""	"MNXR106138"	""	"RCR40600"	"r2241"	"HMR_6147"	""	""	"2.A.60.1.5"	0
@@ -5291,7 +5255,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR06217"	""	""	"HMR_6217"	"r2312"	""	"MNXR106209"	""	"RCR41502"	"r2312"	"HMR_6217"	""	""	"2.A.60.1.14"	0
 "MAR06218"	""	""	"HMR_6218"	"r2313"	""	"MNXR106210"	""	"RCR40670"	"r2313"	"HMR_6218"	""	""	"2.A.60.1.2"	0
 "MAR06219"	""	""	"HMR_6219"	"r2314"	""	"MNXR106211"	""	"RCR40671"	"r2314"	"HMR_6219"	""	""	"2.A.60.1.2"	0
-"MAR06220"	""	""	"HMR_6220"	"r2315"	""	"MNXR106212"	""	"RCR40672"	""	"HMR_6220"	""	""	"2.A.60.1.2"	0
 "MAR06221"	""	""	"HMR_6221"	"r2316"	""	"MNXR106213"	""	"RCR40673"	"r2316"	"HMR_6221"	""	""	"2.A.60.1.2"	0
 "MAR06222"	""	""	"HMR_6222"	"r2317"	""	"MNXR106214"	""	"RCR40674"	"r2317"	"HMR_6222"	""	""	"2.A.60.1.2"	0
 "MAR06223"	""	""	"HMR_6223"	"r2318"	""	"MNXR106215"	""	"RCR40675"	"r2318"	"HMR_6223"	""	""	"2.A.60.1.2"	0
@@ -5323,7 +5286,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR06249"	""	""	"HMR_6249"	"r2343"	""	"MNXR97397"	""	"RCR40696"	"r2343"	"HMR_6249"	""	""	""	0
 "MAR06250"	""	""	"HMR_6250"	"r2344"	""	"MNXR96253"	""	"RCR40055"	"r2344"	"HMR_6250"	""	""	""	0
 "MAR06251"	""	""	"HMR_6251"	"r2345"	""	""	""	"RCR40697"	"LEUKTRD4t"	"HMR_6251"	""	""	""	0
-"MAR06252"	""	""	"HMR_6252"	"r2346"	""	"MNXR106235"	""	"RCR40129"	""	"HMR_6252"	""	""	""	0
 "MAR06253"	""	""	"HMR_6253"	"r2347"	""	"MNXR106236"	""	"RCR40698"	"r2347"	"HMR_6253"	"RHEA:50995"	"RHEA:50992"	""	0
 "MAR06254"	""	""	"HMR_6254"	"r2348"	""	""	""	"RCR40699"	"LEUKTRA4t"	"HMR_6254"	""	""	""	0
 "MAR06255"	""	""	"HMR_6255"	"r2349"	""	""	""	"RCR40274"	"LEUKTRB4t"	"HMR_6255"	""	""	""	0
@@ -5969,7 +5931,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR07719"	"Uritm"	""	"HMR_7719"	""	""	"MNXR105165"	""	"RCR20632"	"Uritm"	"HMR_7719"	""	""	""	0
 "MAR07723"	"CYTDtm"	""	"HMR_7723"	""	""	"MNXR97043"	""	"RCR20633"	"CYTDtm"	"HMR_7723"	""	""	""	0
 "MAR07757"	""	"RT0107"	"HMR_7757"	""	""	""	""	"RCR20634"	"HMR_7757"	"HMR_7757"	""	""	""	0
-"MAR07758"	""	"RT0402"	"HMR_7758"	""	""	""	""	"RCR20277"	"HMR_7758"	"HMR_7758"	""	""	""	0
 "MAR07760"	""	"RT0468"	"HMR_7760"	""	""	""	""	"RCR21071"	"HMR_7760"	"HMR_7760"	""	""	""	0
 "MAR07769"	"AMETt2m"	""	"HMR_7769"	""	""	"MNXR95811"	""	"RCR20182"	"AMETt2m"	"HMR_7769"	""	""	""	0
 "MAR07804"	"DNDPt29m"	""	"HMR_7804"	""	""	"MNXR97628"	""	"RCR20121"	"DNDPt29m;DNDPt10m"	"HMR_7804"	""	""	""	0
@@ -6708,7 +6669,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR09034"	"EX_glc__D_e"	""	"HMR_9034"	""	""	""	""	"RCR30315"	"EX_glc_D[e]"	"HMR_9034"	""	""	""	0
 "MAR09035"	"EX_lnlc_e"	""	"HMR_9035"	""	""	""	""	"RCR30183"	"EX_lnlc[e]"	"HMR_9035"	""	""	""	0
 "MAR09036"	"EX_lnlnca_e"	""	"HMR_9036"	""	""	""	""	"RCR30035"	"EX_lnlnca[e]"	"HMR_9036"	""	""	""	0
-"MAR09037"	""	""	"HMR_9037"	""	""	""	""	"RCR30316"	""	"HMR_9037"	""	""	""	0
+"MAR09037"	"EX_phyt_e"	""	"HMR_9037"	""	""	"MNXR98853"	""	"RCR30316"	"EX_phyt[e]"	"EX_phyt[e];HMR_9037;MAR00659"	""	""	""	0
 "MAR09038"	"EX_his__L_e"	""	"HMR_9038"	""	""	""	""	"RCR30527"	"EX_his_L[e]"	"HMR_9038"	""	""	""	0
 "MAR09039"	"EX_ile__L_e"	""	"HMR_9039"	""	""	""	""	"RCR30528"	"EX_ile_L[e]"	"HMR_9039"	""	""	""	0
 "MAR09040"	"EX_leu__L_e"	""	"HMR_9040"	""	""	""	""	"RCR30529"	"EX_leu_L[e]"	"HMR_9040"	""	""	""	0
@@ -7138,7 +7099,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR09730"	""	""	"HMR_9730"	""	""	""	""	"RCR30245"	"EX_HC00001[e]"	"HMR_9730"	""	""	""	0
 "MAR09725"	""	""	"HMR_9725"	""	""	""	""	"RCR21039"	"HMR_9725"	"HMR_9725"	""	""	""	0
 "MAR00031"	""	""	"HMR_0031"	""	""	""	""	"RCR14835"	"HMR_0031"	"HMR_0031"	""	""	""	0
-"MAR00032"	""	""	"HMR_0032"	""	""	""	""	"RCR14836"	"HMR_0032"	"HMR_0032"	""	""	""	0
 "MAR00021"	""	""	""	""	""	""	""	"RCR21132"	"biomass_components"	"biomass_components"	""	""	""	0
 "MAR00022"	""	""	""	""	""	""	""	"RCR21040"	"cofactors_vitamins"	"cofactors_vitamins"	""	""	""	0
 "MAR00023"	""	""	""	""	""	""	""	"RCR21133"	"vitaminA"	"vitaminA"	""	""	""	0
@@ -7150,7 +7110,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR00038"	"10FTHFtm"	""	""	""	""	"MNXR94672"	""	""	"10FTHFtm"	"10FTHFtm"	""	""	""	0
 "MAR00040"	"34HPLFM"	""	""	""	""	"MNXR94842"	""	""	"34HPLFM"	"34HPLFM"	""	""	""	0
 "MAR00041"	"3DPHBH1"	""	""	""	""	"MNXR94864"	""	""	"3DPHBH1"	"3DPHBH1"	""	""	""	0
-"MAR00042"	"3HBCOAHLm"	""	""	""	""	"MNXR94891"	""	""	"3HBCOAHLm"	"3HBCOAHLm"	""	""	""	0
 "MAR00043"	"3HPCOAHYD"	""	""	""	""	"MNXR94900"	""	""	"3HPCOAHYD"	"3HPCOAHYD"	""	""	""	0
 "MAR00044"	"3HPPD"	""	""	""	""	"MNXR94902"	""	""	"3HPPD"	"3HPPD"	""	""	""	0
 "MAR00045"	"3MOBt2im"	""	""	""	""	"MNXR94923"	""	""	"3MOBt2im"	"3MOBt2im"	""	""	""	0
@@ -7166,7 +7125,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR00056"	"ACACtx"	""	""	""	""	"MNXR95208"	""	""	"ACACtx"	"ACACtx"	"RHEA:29754"	"RHEA:29751"	""	0
 "MAR00057"	"ACCOAtr"	""	""	""	""	"MNXR95223"	""	""	"ACCOAtr"	"ACCOAtr"	""	""	""	0
 "MAR00058"	"ACHVESSEC"	""	""	""	""	"MNXR95266"	""	""	"ACHVESSEC"	"ACHVESSEC"	""	""	""	0
-"MAR00059"	"ACOX22x"	""	""	""	""	"MNXR95389"	""	""	"ACOX22x"	"ACOX22x"	""	""	""	0
 "MAR00060"	"ACRNtm"	""	""	""	""	"MNXR95412"	""	""	"ACRNtm"	"ACRNtm"	""	""	""	0
 "MAR00061"	"ACt2m"	""	""	""	""	"MNXR95429"	""	""	"ACt2m"	"ACt2m"	""	""	""	0
 "MAR00062"	"ADPRDPm"	""	""	""	""	"MNXR95480"	""	""	"ADPRDPm"	"ADPRDPm"	""	""	""	0
@@ -7200,7 +7158,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR00093"	"BTNt2m"	""	""	""	""	"MNXR96334"	""	""	"BTNt2m"	"BTNt2m"	""	""	""	0
 "MAR00094"	"BTNt3i"	""	""	""	""	"MNXR96336"	""	""	"BTNt3i"	"BTNt3i"	""	""	""	0
 "MAR00095"	"BTNt4i"	""	""	""	""	"MNXR96337"	""	""	"BTNt4i"	"BTNt4i"	""	""	""	0
-"MAR00096"	"BUP2"	""	""	""	""	"MNXR96346"	""	""	"BUP2"	"BUP2"	""	""	""	0
 "MAR00097"	"BUTt2m"	""	""	""	""	"MNXR96353"	""	""	"BUTt2m"	"BUTt2m"	""	""	""	0
 "MAR00098"	"BVITEt"	""	""	""	""	"MNXR96355"	""	""	"BVITEt"	"BVITEt"	""	""	""	0
 "MAR00099"	"BZt"	""	""	""	""	"MNXR96370"	""	""	"BZt"	"BZt"	"RHEA:32814"	"RHEA:32811"	""	0
@@ -7290,7 +7247,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR00573"	"EX_crvnc_e"	""	""	""	""	"MNXR98375"	""	""	"EX_crvnc[e]"	"EX_crvnc[e]"	""	""	""	0
 "MAR00574"	"EX_dag_hs_e"	""	""	""	""	"MNXR98395"	""	""	"EX_dag_hs[e]"	"EX_dag_hs[e]"	""	""	""	0
 "MAR00575"	"EX_dcsptn1_e"	""	""	""	""	"MNXR98401"	""	""	"EX_dcsptn1[e]"	"EX_dcsptn1[e]"	""	""	""	0
-"MAR00576"	"EX_dlnlcg_e"	""	""	""	""	"MNXR98420"	""	""	"EX_dlnlcg[e]"	"EX_dlnlcg[e]"	""	""	""	0
+"MAR00576"	"EX_dlnlcg_e"	""	""	""	""	"MNXR98420"	""	""	"EX_CE2516[e];EX_dlnlcg[e]"	"EX_CE2516[e];EX_dlnlcg[e];MAR10433"	""	""	""	0
 "MAR00577"	"EX_eicostet_e"	""	""	""	""	"MNXR98442"	""	""	"EX_eicostet[e]"	"EX_eicostet[e]"	""	""	""	0
 "MAR00583"	"EX_elaid_e"	""	""	""	""	"MNXR98443"	""	""	"EX_elaid[e]"	"EX_elaid[e]"	""	""	""	0
 "MAR00585"	"EX_fucfuc12gal14acglcgalgluside_hs_e"	""	""	""	""	"MNXR98508"	""	""	"EX_fucfuc12gal14acglcgalgluside_hs[e]"	"EX_fucfuc12gal14acglcgalgluside_hs[e]"	""	""	""	0
@@ -7315,7 +7272,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR00655"	"EX_pchol_hs_e"	""	""	""	""	"MNXR98826"	""	""	"EX_pchol_hs[e]"	"EX_pchol_hs[e]"	""	""	""	0
 "MAR00656"	"EX_pe_hs_e"	""	""	""	""	"MNXR98829"	""	""	"EX_pe_hs[e]"	"EX_pe_hs[e]"	""	""	""	0
 "MAR00658"	"EX_pglyc_hs_e"	""	""	""	""	"MNXR98843"	""	""	"EX_pglyc_hs[e]"	"EX_pglyc_hs[e]"	""	""	""	0
-"MAR00659"	"EX_phyt_e"	""	""	""	""	"MNXR98853"	""	""	"EX_phyt[e]"	"EX_phyt[e]"	""	""	""	0
 "MAR00661"	"EX_ps_hs_e"	""	""	""	""	"MNXR98877"	""	""	"EX_ps_hs[e]"	"EX_ps_hs[e]"	""	""	""	0
 "MAR00662"	"EX_ptdca_e"	""	""	""	""	"MNXR98887"	""	""	"EX_ptdca[e]"	"EX_ptdca[e]"	""	""	""	0
 "MAR00666"	"EX_retfa_e"	""	""	""	""	"MNXR98903"	""	""	"EX_retfa[e]"	"EX_retfa[e]"	""	""	""	0
@@ -7402,7 +7358,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR01078"	"FUCFUCGALACGLCGALGLUSIDEtg"	""	""	""	""	"MNXR99694"	""	""	"FUCFUCGALACGLCGALGLUSIDEtg"	"FUCFUCGALACGLCGALGLUSIDEtg"	""	""	""	0
 "MAR01118"	"FUT34g"	""	""	""	""	"MNXR99739"	""	""	"FUT34g"	"FUT34g"	""	""	""	0
 "MAR01141"	"FUT93g"	""	""	""	""	"MNXR99751"	""	""	"FUT93g"	"FUT93g"	""	""	""	0
-"MAR01169"	"G3PD2m"	""	""	""	""	"MNXR99878"	""	""	"G3PD2m"	"G3PD2m"	""	""	""	0
+"MAR01169"	"G3PD2m"	""	"HMR_0483"	"r0205"	"R00849"	"MNXR99878;MNXR106713"	""	"RCR21050"	"G3PD2m;r0205"	"G3PD2m;HMR_0483"	""	"RHEA:18977"	""	0
 "MAR01314"	"GABAVESSEC"	""	""	""	""	"MNXR99916"	""	""	"GABAVESSEC"	"GABAVESSEC"	""	""	""	0
 "MAR01340"	"GALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg"	""	""	""	""	"MNXR99968"	""	""	"GALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg"	"GALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg"	""	""	""	0
 "MAR01348"	"GALGLUSIDEtg"	""	""	""	""	"MNXR99974"	""	""	"GALGLUSIDEtg"	"GALGLUSIDEtg"	""	""	""	0
@@ -7436,7 +7392,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR01453"	"HPYRR2x"	""	""	""	""	"MNXR100701"	""	""	"HPYRR2x"	"HPYRR2x"	""	""	""	0
 "MAR01455"	"HRETNtn"	""	""	""	""	"MNXR100704"	""	""	"HRETNtn"	"HRETNtn"	""	""	""	0
 "MAR01456"	"HSD17B42x"	""	""	""	""	"MNXR100718"	""	""	"HSD17B42x"	"HSD17B42x"	""	""	""	0
-"MAR01458"	"HSD17B4x"	""	""	""	""	"MNXR100720"	""	""	"HSD17B4x"	"HSD17B4x"	""	""	""	0
 "MAR01461"	"Htr"	""	""	""	""	"MNXR100765"	""	""	"Htr"	"Htr"	"RHEA:34982"	"RHEA:34979"	""	0
 "MAR01462"	"Htx"	""	""	""	""	"MNXR100765"	""	""	"Htx"	"Htx"	"RHEA:34982"	"RHEA:34979"	""	0
 "MAR01463"	"HXANtl"	""	""	""	""	"MNXR100749"	""	""	"HXANtl"	"HXANtl"	""	""	""	0
@@ -7506,7 +7461,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR01612"	"PGPP_hs"	""	""	""	""	"MNXR102585"	""	""	"PGPP_hs"	"PGPP_hs"	""	""	""	0
 "MAR01615"	"PGPPT"	""	""	""	""	"MNXR102578"	""	""	"PGPPT"	"PGPPT"	""	""	""	0
 "MAR01616"	"PHETA1m"	""	""	""	""	"MNXR102631"	""	""	"PHETA1m"	"PHETA1m"	""	""	""	0
-"MAR01617"	"PHYTt"	""	""	""	""	"MNXR102660"	""	""	"PHYTt"	"PHYTt"	""	""	""	0
 "MAR01618"	"PI4P3Ker"	""	""	""	""	"MNXR102746"	""	""	"PI4P3Ker"	"PI4P3Ker"	""	""	""	0
 "MAR01626"	"PItx"	""	""	""	""	"MNXR102871"	""	""	"PItx"	"PItx"	"RHEA:32826"	"RHEA:32823"	""	0
 "MAR01628"	"PMEVKx"	""	""	""	""	"MNXR103043"	""	""	"PMEVKx"	"PMEVKx"	"RHEA:16342"	"RHEA:16341"	""	0
@@ -7536,7 +7490,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR01698"	"RETFAt"	""	""	""	""	"MNXR103996"	""	""	"RETFAt"	"RETFAt"	""	""	""	0
 "MAR01705"	"RETFAt1"	""	""	""	""	"MNXR103997"	""	""	"RETFAt1"	"RETFAt1"	""	""	""	0
 "MAR01707"	"RIBt2"	""	""	""	""	"MNXR104037"	""	""	"RIBt2"	"RIBt2"	""	""	""	0
-"MAR01709"	"SCP22x"	""	""	""	""	"MNXR104294"	""	""	"SCP22x"	"SCP22x"	""	""	""	0
 "MAR01711"	"SCP2x"	""	""	""	""	"MNXR104295"	""	""	"SCP2x"	"SCP2x"	""	""	""	0
 "MAR01712"	"Ser_Thrtg"	""	""	""	""	"MNXR104656"	""	""	"Ser_Thrtg"	"Ser_Thrtg"	""	""	""	0
 "MAR01719"	"STCOAtx"	""	""	""	""	"MNXR104598"	""	""	"STCOAtx"	"STCOAtx"	""	""	""	0
@@ -7568,7 +7521,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR01820"	"UGT1A10r"	""	""	""	""	"MNXR96258"	""	""	"UGT1A10r"	"UGT1A10r"	""	""	""	0
 "MAR01821"	"VALt5m"	""	""	""	""	"MNXR105190"	""	""	"VALt5m"	"VALt5m"	""	""	""	0
 "MAR01822"	"VITD3tm"	""	""	""	""	"MNXR105203"	""	""	"VITD3tm"	"VITD3tm"	""	""	""	0
-"MAR01823"	"VITD3tm3"	""	""	""	""	"MNXR105203"	""	""	"VITD3tm3"	"VITD3tm3"	""	""	""	0
 "MAR01824"	"XOL27OHtm"	""	""	""	""	"MNXR105232"	""	""	"XOL27OHtm"	"XOL27OHtm"	""	""	""	0
 "MAR01825"	"XOL7AH2tr"	""	""	""	""	"MNXR105233"	""	""	"XOL7AH2tr"	"XOL7AH2tr"	""	""	""	0
 "MAR01826"	"XOLDIOLONEtm"	""	""	""	""	"MNXR105235"	""	""	"XOLDIOLONEtm"	"XOLDIOLONEtm"	""	""	""	0
@@ -7605,9 +7557,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR01984"	"EX_prpp_e"	""	""	""	""	"MNXR98875"	""	""	"EX_prpp[e]"	"EX_prpp[e]"	""	""	""	0
 "MAR01986"	"EX_udpg_e"	""	""	""	""	"MNXR99017"	""	""	"EX_udpg[e]"	"EX_udpg[e]"	""	""	""	0
 "MAR02023"	"r0145"	""	""	""	""	""	""	""	"r0145"	"r0145"	""	""	""	0
-"MAR02027"	"r0193"	""	""	""	""	"MNXR105313"	""	""	"r0193"	"r0193"	""	""	""	0
 "MAR02028"	"ACOAR7m"	""	""	""	""	"MNXR95375"	""	""	"r0309"	"r0309"	""	""	""	0
-"MAR02035"	"r0310"	""	""	""	""	""	""	""	"r0310"	"r0310"	""	""	""	0
 "MAR02119"	"r0403"	""	""	""	""	""	""	""	"r0403"	"r0403"	""	""	""	0
 "MAR02120"	"r0410"	""	""	""	""	"MNXR102049"	""	""	"r0410"	"r0410"	"RHEA:28365"	"RHEA:28362"	""	0
 "MAR02121"	"r0437"	""	""	""	""	"MNXR96384"	""	""	"r0437"	"r0437"	""	""	""	0
@@ -7620,7 +7570,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR02149"	"ACOAR5m"	""	""	""	""	"MNXR95373"	""	""	"r0638"	"r0638"	""	""	""	0
 "MAR02183"	"r0652"	""	""	""	""	"MNXR105364"	""	""	"r0652"	"r0652"	""	""	""	0
 "MAR02184"	"r0672"	""	""	""	""	"MNXR105366"	""	""	"r0672"	"r0672"	""	""	""	0
-"MAR02185"	""	""	""	""	""	""	""	""	"r0701"	"r0701"	""	""	""	0
 "MAR02186"	"r0707"	""	""	""	""	"MNXR95665"	""	""	"r0707"	"r0707"	""	""	""	0
 "MAR02187"	"ACOAR4m"	""	""	""	""	"MNXR95372"	""	""	"r0735"	"r0735"	"RHEA:44963"	"RHEA:44960"	""	0
 "MAR02188"	"r0752"	""	""	""	""	"MNXR94840"	""	""	"r0752"	"r0752"	""	""	""	0
@@ -7643,8 +7592,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR02273"	"r0986"	""	""	""	""	"MNXR101107"	""	""	"r0986"	"r0986"	""	""	""	0
 "MAR02274"	"r0988"	""	""	""	""	"MNXR101014"	""	""	"r0988"	"r0988"	""	""	""	0
 "MAR02275"	"r0989"	""	""	""	""	"MNXR105412"	""	""	"r0989"	"r0989"	""	""	""	0
-"MAR02276"	"r0993"	""	""	""	""	"MNXR105414"	""	""	"r0993"	"r0993"	""	""	""	0
-"MAR02277"	"r0994"	""	""	""	""	"MNXR105415"	""	""	"r0994"	"r0994"	""	""	""	0
 "MAR02278"	"r0999"	""	""	""	""	"MNXR105417"	""	""	"r0999"	"r0999"	""	""	""	0
 "MAR02279"	"r1003"	""	""	""	""	"MNXR105419"	""	""	"r1003"	"r1003"	""	""	""	0
 "MAR02280"	"r1008"	""	""	""	""	"MNXR105421"	""	""	"r1008"	"r1008"	""	""	""	0
@@ -7681,28 +7628,18 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR02351"	"PIt"	""	""	""	""	"MNXR102871"	""	""	"r1423"	"r1423"	"RHEA:32824"	"RHEA:32823"	""	0
 "MAR02352"	""	""	""	""	""	""	""	""	"r1431"	"r1431"	""	""	""	0
 "MAR02357"	""	""	""	""	""	""	""	""	"r1432"	"r1432"	""	""	""	0
-"MAR02358"	""	""	""	""	""	""	""	""	"r1433"	"r1433"	""	""	""	0
 "MAR02360"	"r1441"	""	""	""	""	"MNXR104924"	""	""	"r1441"	"r1441"	""	""	""	0
-"MAR02366"	"r1446"	""	""	""	""	""	""	""	"r1446"	"r1446"	""	""	""	0
-"MAR02367"	"r1447"	""	""	""	""	""	""	""	"r1447"	"r1447"	""	""	""	0
-"MAR02369"	"r1448"	""	""	""	""	""	""	""	"r1448"	"r1448"	""	""	""	0
-"MAR02370"	"r1449"	""	""	""	""	""	""	""	"r1449"	"r1449"	""	""	""	0
-"MAR02372"	"r1450"	""	""	""	""	""	""	""	"r1450"	"r1450"	""	""	""	0
-"MAR02373"	"r1451"	""	""	""	""	""	""	""	"r1451"	"r1451"	""	""	""	0
 "MAR02375"	"r1466"	""	""	""	""	"MNXR105476"	""	""	"r1466"	"r1466"	""	""	""	0
 "MAR02377"	"r1467"	""	""	""	""	"MNXR102156"	""	""	"r1467"	"r1467"	""	""	""	0
 "MAR02379"	"r1468"	""	""	""	""	"MNXR105477"	""	""	"r1468"	"r1468"	""	""	""	0
 "MAR02381"	"r1481"	""	""	""	""	""	""	""	"r1481"	"r1481"	""	""	""	0
 "MAR02382"	"GTHRDt2"	""	""	""	""	"MNXR100449"	""	""	"r1493"	"r1493"	""	""	""	0
 "MAR02388"	"r1540"	""	""	""	""	""	""	""	"r1540"	"r1540"	""	""	""	0
-"MAR02390"	"r2157"	""	""	""	""	"MNXR106054"	""	""	"r2157"	"r2157"	""	""	""	0
-"MAR02392"	"r2158"	""	""	""	""	"MNXR106055"	""	""	"r2158"	"r2158"	""	""	""	0
-"MAR02394"	"r2159"	""	""	""	""	"MNXR106056"	""	""	"r2159"	"r2159"	""	""	""	0
-"MAR02396"	"r2236"	""	""	""	""	"MNXR106133"	""	""	"r2236"	"r2236"	""	""	""	0
-"MAR02398"	"r2237"	""	""	""	""	"MNXR106134"	""	""	"r2237"	"r2237"	""	""	""	0
-"MAR02400"	"r2238"	""	""	""	""	"MNXR106135"	""	""	"r2238"	"r2238"	""	""	""	0
-"MAR02402"	"r2315"	""	""	""	""	"MNXR106212"	""	""	"r2315"	"r2315"	""	""	""	0
-"MAR02404"	"r2346"	""	""	""	""	"MNXR106235"	""	""	"r2346"	"r2346"	""	""	""	0
+"MAR02396"	"r2236"	""	"HMR_6142"	"r2236"	""	"MNXR106133"	""	"RCR40595"	"r2236"	"HMR_6142;r2236;MAR06142"	""	""	"2.A.60.1.5"	0
+"MAR02398"	"r2237"	""	"HMR_6143"	"r2237"	""	"MNXR106134"	""	"RCR40596"	"r2237"	"HMR_6143;r2237;MAR06143"	""	""	"2.A.60.1.5"	0
+"MAR02400"	"r2238"	""	"HMR_6144"	"r2238"	""	"MNXR106135"	""	"RCR40597"	"r2238"	"HMR_6144;r2238;MAR06144"	""	""	"2.A.60.1.5"	0
+"MAR02402"	"r2315"	""	"HMR_6220"	"r2315"	""	"MNXR106212"	""	"RCR40672"	"r2315"	"HMR_6220;r2315;MAR06220"	""	""	"2.A.60.1.2"	0
+"MAR02404"	"r2346"	""	"HMR_6252"	"r2346"	""	"MNXR106235"	""	"RCR40129"	"r2346"	"HMR_6252;r2346;MAR06252"	""	""	""	0
 "MAR02405"	"AKGCITtm"	""	""	""	""	"MNXR95654"	""	""	"r2373"	"r2373"	""	""	""	0
 "MAR02406"	"r2374"	""	""	""	""	"MNXR106255"	""	""	"r2374"	"r2374"	""	""	""	0
 "MAR02413"	"r2375"	""	""	""	""	"MNXR106256"	""	""	"r2375"	"r2375"	""	""	""	0
@@ -7759,10 +7696,10 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR02784"	"RE1448N"	""	""	""	""	"MNXR103512"	""	""	"RE1448N"	"RE1448N"	""	""	""	0
 "MAR02786"	""	""	""	""	""	""	""	""	"RE1514M"	"RE1514M"	""	""	""	0
 "MAR02802"	""	""	""	""	""	""	""	""	"RE1514X"	"RE1514X"	""	""	""	0
-"MAR02804"	"RE1516X"	""	""	""	""	""	""	""	"RE1516X"	"RE1516X"	""	""	""	0
-"MAR02808"	"RE1517X"	""	""	""	""	""	""	""	"RE1517X"	"RE1517X"	""	""	""	0
-"MAR02810"	"RE1518X"	""	""	""	""	""	""	""	"RE1518X"	"RE1518X"	""	""	""	0
-"MAR02818"	"RE1519X"	""	""	""	""	""	""	""	"RE1519X"	"RE1519X"	""	""	""	0
+"MAR02804"	"RE1516X"	"RE1516X"	"HMR_3301"	""	""	""	""	"RCR12606"	"RE1516X"	"RE1516X;HMR_3301"	""	""	""	0
+"MAR02808"	"RE1517X"	"RE1517X"	"HMR_3306"	""	""	""	""	"RCR12610"	"RE1517X"	"RE1517X;HMR_3306;MAR00306"	""	""	""	0
+"MAR02810"	"RE1518X"	"RE1518X"	"HMR_3311"	""	""	""	""	"RCR14519"	"RE1518X"	"RE1518X;HMR_3311;MAR03311"	""	""	""	0
+"MAR02818"	"RE1519X;FAOXC101C102x"	""	""	""	""	""	""	""	"RE1519X;FAOXC101C102x"	"RE1519X;FAOXC101C102x;MAR04966"	""	""	""	0
 "MAR02820"	"RE1525C"	""	""	""	""	"MNXR103515"	""	""	"RE1525C"	"RE1525C"	""	""	""	0
 "MAR02826"	"RE1526C"	""	""	""	""	"MNXR103516"	""	""	"RE1526C"	"RE1526C"	""	""	""	0
 "MAR02828"	"RE1527C"	""	""	""	""	"MNXR103517"	""	""	"RE1527C"	"RE1527C"	""	""	""	0
@@ -7849,8 +7786,8 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR03271"	""	""	""	""	""	""	""	""	"RE2911C"	"RE2911C"	""	""	""	0
 "MAR03273"	"RE2912M"	""	""	""	""	""	""	""	"RE2912M"	"RE2912M"	""	""	""	0
 "MAR03274"	""	""	""	""	""	""	""	""	"RE2912X"	"RE2912X"	""	""	""	0
-"MAR03276"	""	""	""	""	""	""	""	""	"RE2913X"	"RE2913X"	""	""	""	0
-"MAR03289"	""	""	""	""	""	""	""	""	"RE2914X"	"RE2914X"	""	""	""	0
+"MAR03276"	""	"RE2913X"	"HMR_3364"	""	""	""	""	"RCR12576"	"RE2913X"	"RE2913X;HMR_3364;MAR03364"	""	""	""	0
+"MAR03289"	""	"RE2914X"	"HMR_3369"	""	""	""	""	"RCR12580"	"RE2914X"	"RE2914X;HMR_3369;MAR03369"	""	""	""	0
 "MAR03291"	""	""	""	""	""	""	""	""	"RE2915M"	"RE2915M"	""	""	""	0
 "MAR03295"	""	""	""	""	""	""	""	""	"RE2915X"	"RE2915X"	""	""	""	0
 "MAR03297"	""	""	""	""	""	""	""	""	"RE2921M"	"RE2921M"	""	""	""	0
@@ -7902,7 +7839,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR03438"	""	""	""	""	""	""	""	""	"RE3147R"	"RE3147R"	""	""	""	0
 "MAR03439"	""	""	""	""	""	""	""	""	"RE3148C"	"RE3148C"	""	""	""	0
 "MAR03440"	""	""	""	""	""	""	""	""	"RE3148R"	"RE3148R"	""	""	""	0
-"MAR03441"	"RE3150C"	""	""	""	""	"MNXR103806"	""	""	"RE3150C"	"RE3150C"	""	""	""	0
 "MAR03442"	"RE3150R"	""	""	""	""	"MNXR103806"	""	""	"RE3150R"	"RE3150R"	""	""	""	0
 "MAR03443"	""	""	""	""	""	""	""	""	"RE3151R"	"RE3151R"	""	""	""	0
 "MAR03451"	""	""	""	""	""	""	""	""	"RE3152R"	"RE3152R"	""	""	""	0
@@ -7948,10 +7884,8 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR03624"	"RE3243R"	""	""	""	""	"MNXR103848"	""	""	"RE3243R"	"RE3243R"	""	""	""	0
 "MAR03745"	"RE3244C"	""	""	""	""	"MNXR103849"	""	""	"RE3244C"	"RE3244C"	""	""	""	0
 "MAR03749"	"RE3244R"	""	""	""	""	"MNXR103849"	""	""	"RE3244R"	"RE3244R"	""	""	""	0
-"MAR03754"	""	""	""	""	""	""	""	""	"RE3248M"	"RE3248M"	""	""	""	0
 "MAR03758"	"RE3250C"	""	""	""	""	"MNXR103850"	""	""	"RE3250C"	"RE3250C"	""	""	""	0
-"MAR03760"	""	""	""	""	""	""	""	""	"RE3250M"	"RE3250M"	""	""	""	0
-"MAR03764"	""	""	""	""	""	""	""	""	"RE3250X"	"RE3250X"	""	""	""	0
+"MAR03764"	""	""	""	""	""	""	""	""	"RE3250X;RE3250M"	"RE3250X;RE3250M;MAR03760"	""	""	""	0
 "MAR03766"	"RE3251C"	""	""	""	""	"MNXR103851"	""	""	"RE3251C"	"RE3251C"	""	""	""	0
 "MAR03768"	"RE3251M"	""	""	""	""	"MNXR103851"	""	""	"RE3251M"	"RE3251M"	""	""	""	0
 "MAR03774"	"RE3252C"	""	""	""	""	"MNXR103852"	""	""	"RE3252C"	"RE3252C"	""	""	""	0
@@ -8051,7 +7985,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR04138"	""	""	""	""	""	""	""	""	"EX_HC01943[e]"	"EX_HC01943[e]"	""	""	""	0
 "MAR04140"	""	""	""	""	""	""	""	""	"EX_HC01944[e]"	"EX_HC01944[e]"	""	""	""	0
 "MAR04142"	"EX_HC00822_e"	""	""	""	""	"MNXR98137"	""	""	"EX_HC00822[e]"	"EX_HC00822[e]"	""	""	""	0
-"MAR04144"	"EX_C02528_e"	""	""	""	""	"MNXR98101"	""	""	"EX_C02528[e]"	"EX_C02528[e]"	""	""	""	0
 "MAR04146"	"EX_HC02192_e"	""	""	""	""	"MNXR98156"	""	""	"EX_HC02192[e]"	"EX_HC02192[e]"	""	""	""	0
 "MAR04148"	"EX_HC02193_e"	""	""	""	""	"MNXR98157"	""	""	"EX_HC02193[e]"	"EX_HC02193[e]"	""	""	""	0
 "MAR04150"	"EX_HC02195_e"	""	""	""	""	"MNXR98159"	""	""	"EX_HC02195[e]"	"EX_HC02195[e]"	""	""	""	0
@@ -8135,7 +8068,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR04479"	"C10DCCACT"	""	""	""	""	"MNXR96374"	""	""	"C10DCCACT"	"C10DCCACT"	""	""	""	0
 "MAR04491"	"C10DCc"	""	""	""	""	"MNXR96375"	""	""	"C10DCc"	"C10DCc"	""	""	""	0
 "MAR04504"	"C10OHc"	""	""	""	""	"MNXR96376"	""	""	"C10OHc"	"C10OHc"	""	""	""	0
-"MAR04506"	"C120CPT1"	""	""	""	""	""	""	""	"C120CPT1"	"C120CPT1"	""	""	""	0
 "MAR04508"	"C121CPT1"	""	""	""	""	""	""	""	"C121CPT1"	"C121CPT1"	""	""	""	0
 "MAR04511"	"C12DCACT"	""	""	""	""	""	""	""	"C12DCACT"	"C12DCACT"	""	""	""	0
 "MAR04515"	"C12DCTD"	""	""	""	""	""	""	""	"C12DCTD"	"C12DCTD"	""	""	""	0
@@ -8216,7 +8148,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR04943"	"EX_ivcrn_e"	""	""	""	""	"MNXR98685"	""	""	"EX_ivcrn[e]"	"EX_ivcrn[e]"	""	""	""	0
 "MAR04950"	"EX_tetdec2crn_e"	""	""	""	""	""	""	""	"EX_tetdec2crn[e]"	"EX_tetdec2crn[e]"	""	""	""	0
 "MAR04965"	"EX_tetdece1crn_e"	""	""	""	""	""	""	""	"EX_tetdece1crn[e]"	"EX_tetdece1crn[e]"	""	""	""	0
-"MAR04966"	"FAOXC101C102x"	""	""	""	""	""	""	""	"FAOXC101C102x"	"FAOXC101C102x"	""	""	""	0
 "MAR04967"	"FAOXC101C8m"	""	""	""	""	""	""	""	"FAOXC101C8m"	"FAOXC101C8m"	""	""	""	0
 "MAR04968"	"FAOXC101C8x"	""	""	""	""	""	""	""	"FAOXC101C8x"	"FAOXC101C8x"	""	""	""	0
 "MAR04978"	"FAOXC102C103m"	""	""	""	""	""	""	""	"FAOXC102C103m"	"FAOXC102C103m"	""	""	""	0
@@ -8410,7 +8341,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR06891"	"CYSTALArBATtc"	""	""	""	""	"MNXR97011"	""	""	"CYSTALArBATtc"	"CYSTALArBATtc"	""	""	""	0
 "MAR06892"	"CYSTLEUrBATtc"	""	""	""	""	"MNXR97016"	""	""	"CYSTLEUrBATtc"	"CYSTLEUrBATtc"	""	""	""	0
 "MAR06893"	"FOLt"	""	""	""	""	"MNXR99612"	""	""	"FOLTle"	"FOLTle"	""	""	""	0
-"MAR06896"	"GLNATB0tc"	""	""	""	""	"MNXR100248"	""	""	"GLNATB0tc"	"GLNATB0tc"	""	""	""	0
+"MAR06896"	"GLNATB0tc;GLNB0AT3tc"	""	""	""	""	"MNXR100248"	""	""	"GLNATB0tc;GLNB0AT3tc"	"GLNATB0tc;GLNB0AT3tc;MAR09887"	""	""	""	0
 "MAR06897"	"GLNyLATthc"	""	""	""	""	"MNXR100264"	""	""	"GLNyLATthc"	"GLNyLATthc"	""	""	""	0
 "MAR06899"	"GLYGLYPEPT1tc"	""	""	""	""	"MNXR100346"	""	""	"GLYGLYPEPT1tc"	"GLYGLYPEPT1tc"	""	""	""	0
 "MAR06900"	"GLYPHEPEPT1tc"	""	""	""	""	"MNXR100358"	""	""	"GLYPHEPEPT1tc"	"GLYPHEPEPT1tc"	""	""	""	0
@@ -8630,7 +8561,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR09884"	"FOLOAT2tc"	""	""	""	""	""	""	""	"FOLOAT2tc"	"FOLOAT2tc"	""	""	""	0
 "MAR09885"	"FOLOATPtc"	""	""	""	""	""	""	""	"FOLOATPtc"	"FOLOATPtc"	""	""	""	0
 "MAR09886"	"GABABGTtc"	""	""	""	""	""	""	""	"GABABGTtc"	"GABABGTtc"	""	""	""	0
-"MAR09887"	"GLNB0AT3tc"	""	""	""	""	""	""	""	"GLNB0AT3tc"	"GLNB0AT3tc"	""	""	""	0
 "MAR09888"	"GLUB0AT3tc"	""	""	""	""	""	""	""	"GLUB0AT3tc"	"GLUB0AT3tc"	""	""	""	0
 "MAR09889"	"GSNt2"	""	""	""	""	"MNXR100434"	""	""	"GSNt2r"	"GSNt2r"	"RHEA:29586"	"RHEA:29583"	""	0
 "MAR09891"	"ILEB0AT3tc"	""	""	""	""	""	""	""	"ILEB0AT3tc"	"ILEB0AT3tc"	""	""	""	0
@@ -8790,7 +8720,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR10161"	"CE2028t"	""	""	""	""	""	""	""	"CE2028t"	"CE2028t"	""	""	""	0
 "MAR10162"	"CE2176t"	""	""	""	""	""	""	""	"CE2176t"	"CE2176t"	""	""	""	0
 "MAR10163"	"CE2445t"	""	""	""	""	""	""	""	"CE2445t"	"CE2445t"	""	""	""	0
-"MAR10164"	""	""	""	""	""	""	""	""	"CE2516t"	"CE2516t"	""	""	""	0
 "MAR10165"	"CE2537ATP"	""	""	""	""	""	""	""	"CE2537ATP"	"CE2537ATP"	""	""	""	0
 "MAR10166"	"CE4843t"	""	""	""	""	""	""	""	"CE4843t"	"CE4843t"	""	""	""	0
 "MAR10167"	"CE4843td"	""	""	""	""	""	""	""	"CE4843td"	"CE4843td"	""	""	""	0
@@ -8974,7 +8903,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR10345"	"EX_ttdcrn_e"	""	""	""	""	"MNXR98998"	""	""	"EX_ttdcrn[e]"	"EX_ttdcrn[e]"	""	""	""	0
 "MAR10346"	"EX_txb2_e;EX_HC02180_e"	""	""	""	""	"MNXR106236"	""	""	"EX_txb2[e];EX_HC02180[e]"	"EX_txb2[e]"	""	""	""	0
 "MAR10347"	"EX_urcan_e"	""	""	""	""	""	""	""	"EX_urcan[e]"	"EX_urcan[e]"	""	""	""	0
-"MAR10348"	"EX_wharachd_e"	""	""	""	""	"MNXR99036"	""	""	"EX_wharachd[e]"	"EX_wharachd[e]"	""	""	""	0
+"MAR10348"	"EX_wharachd_e"	""	""	""	""	"MNXR99036"	""	""	"EX_wharachd[e]"	"EX_wharachd[e];HMR_10025;MAR10025"	""	""	""	0
 "MAR10349"	"EX_xolest181_hs_e"	""	""	""	""	""	""	""	"EX_xolest181_hs[e]"	"EX_xolest181_hs[e]"	""	""	""	0
 "MAR10350"	"EX_xolest182_hs_e"	""	""	""	""	""	""	""	"EX_xolest182_hs[e]"	"EX_xolest182_hs[e]"	""	""	""	0
 "MAR10351"	"EX_xolest183_hs_e"	""	""	""	""	""	""	""	"EX_xolest183_hs[e]"	"EX_xolest183_hs[e]"	""	""	""	0
@@ -9058,7 +8987,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR10430"	"EX_acglu_e"	""	""	""	""	""	""	""	"EX_acglu[e]"	"EX_acglu[e]"	""	""	""	0
 "MAR10431"	"EX_alltn_e"	""	""	""	""	"MNXR98261"	""	""	"EX_alltn[e]"	"EX_alltn[e]"	""	""	""	0
 "MAR10432"	"EX_CE2510_e"	""	""	""	""	""	""	""	"EX_CE2510[e]"	"EX_CE2510[e]"	""	""	""	0
-"MAR10433"	""	""	""	""	""	""	""	""	"EX_CE2516[e]"	"EX_CE2516[e]"	""	""	""	0
 "MAR10434"	"EX_ddca_e"	""	""	""	""	"MNXR98403"	""	""	"EX_ddca[e]"	"EX_ddca[e]"	""	""	""	0
 "MAR10435"	"EX_glyc2p_e"	""	""	""	""	"MNXR98598"	""	""	"EX_glyc2p[e]"	"EX_glyc2p[e]"	""	""	""	0
 "MAR10436"	"EX_glyclt_e"	""	""	""	""	"MNXR98603"	""	""	"EX_glyclt[e]"	"EX_glyclt[e]"	""	""	""	0
@@ -9070,7 +8998,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR10442"	"EX_ttdcea_e"	""	""	""	""	"MNXR98997"	""	""	"EX_ttdcea[e]"	"EX_ttdcea[e]"	""	""	""	0
 "MAR10443"	"3HPPPNOHGLUCc"	""	""	""	""	""	""	""	"3HPPPNOHGLUCc"	"3HPPPNOHGLUCc"	""	""	""	0
 "MAR10444"	"ACHOMm"	""	""	""	""	""	""	""	"ACHOMm"	"ACHOMm"	""	""	""	0
-"MAR10447"	"HC02220c"	""	""	""	""	""	""	""	"HC02220c"	"HC02220c"	""	""	""	0
 "MAR10448"	"7KLITCHOLc"	""	""	""	""	""	""	""	"7KLITCHOLc"	"7KLITCHOLc"	""	""	""	0
 "MAR10449"	"HC02194c"	""	""	""	""	""	""	""	"HC02194c"	"HC02194c"	""	""	""	0
 "MAR10450"	"URSCHOLCOAc"	""	""	""	""	""	""	""	"URSCHOLCOAc"	"URSCHOLCOAc"	""	""	""	0
@@ -9088,12 +9015,9 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR10463"	""	""	""	""	""	""	""	""	"INDOLEup"	"INDOLEup"	""	""	""	0
 "MAR10464"	""	""	""	""	""	""	""	""	"INDSt"	"INDSt"	""	""	""	0
 "MAR10465"	"PCRESOLup"	""	""	""	""	""	""	""	"PCRESOLup"	"PCRESOLup"	""	""	""	0
-"MAR10466"	"PCSsec"	""	""	""	""	""	""	""	"PCSsec"	"PCSsec"	""	""	""	0
-"MAR10467"	""	""	""	""	""	""	""	""	"PCSup"	"PCSup"	""	""	""	0
-"MAR10468"	""	""	""	""	""	""	""	""	"3HCINNMup"	"3HCINNMup"	""	""	""	0
-"MAR10469"	""	""	""	""	""	""	""	""	"3HCINNMsec"	"3HCINNMsec"	""	""	""	0
-"MAR10470"	""	""	""	""	""	""	""	""	"3HPPAup"	"3HPPAup"	""	""	""	0
-"MAR10471"	""	""	""	""	""	""	""	""	"3HPPAsec"	"3HPPAsec"	""	""	""	0
+"MAR10466"	"PCSsec"	""	""	""	""	""	""	""	"PCSsec;PCSup"	"PCSsec;PCSup"	""	""	""	0
+"MAR10468"	""	""	""	""	""	""	""	""	"3HCINNMup;3HCINNMsec"	"3HCINNMup;3HCINNMsec"	""	""	""	0
+"MAR10470"	""	""	""	""	""	""	""	""	"3HPPAup;3HPPAsec"	"3HPPAup;3HPPAsec"	""	""	""	0
 "MAR10472"	""	""	""	""	""	""	""	""	"EX_3hcinnm[e]"	"EX_3hcinnm[e]"	""	""	""	0
 "MAR10473"	""	""	""	""	""	""	""	""	"EX_3hppa[e]"	"EX_3hppa[e]"	""	""	""	0
 "MAR10474"	"EX_bgly_e"	""	""	""	""	""	""	""	"EX_bgly[e]"	"EX_bgly[e]"	""	""	""	0
@@ -10192,10 +10116,10 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR11580"	"CE7172UPKt"	""	""	""	""	""	""	""	"CE7172UPKt"	"CE7172UPKt"	""	""	""	0
 "MAR11581"	"NRVNCABCt"	""	""	""	""	""	""	""	"NRVNCABCt"	"NRVNCABCt"	""	""	""	0
 "MAR11582"	"PAFABCt"	""	""	""	""	""	""	""	"PAFABCt"	"PAFABCt"	""	""	""	0
-"MAR11583"	"PAIL_hs_SECt"	""	""	""	""	""	""	""	"PAIL_hs_SECt"	"PAIL_hs_SECt"	""	""	""	0
-"MAR11584"	"PAILPALM_HSSECt"	""	""	""	""	""	""	""	"PAILPALM_HSSECt"	"PAILPALM_HSSECt"	""	""	""	0
-"MAR11585"	"PAILR_HSSECt"	""	""	""	""	""	""	""	"PAILR_HSSECt"	"PAILR_HSSECt"	""	""	""	0
-"MAR11586"	""	""	""	""	""	""	""	""	"PAILSTE_HSSECt"	"PAILSTE_HSSECt"	""	""	""	0
+"MAR11583"	"PAIL_hs_SECt"	""	""	""	""	""	""	""	"PAIL_hs_SECt;PAIL_hs_t1e"	"PAIL_hs_SECt;PAIL_hs_t1e"	""	""	""	0
+"MAR11584"	"PAILPALM_HSSECt"	""	""	""	""	""	""	""	"PAILPALM_HSSECt;PAILPALM_HSt1e"	"PAILPALM_HSSECt;PAILPALM_HSt1e"	""	""	""	0
+"MAR11585"	"PAILR_HSSECt"	""	""	""	""	""	""	""	"PAILR_HSSECt;PAILR_HSt1e"	"PAILR_HSSECt;PAILR_HSt1e"	""	""	""	0
+"MAR11586"	""	""	""	""	""	""	""	""	"PAILSTE_HSSECt;PAILSTE_HSt1e"	"PAILSTE_HSSECt;PAILSTE_HSt1e"	""	""	""	0
 "MAR11587"	"PCHLN225_HSABCt"	""	""	""	""	""	""	""	"PCHLN225_HSABCt"	"PCHLN225_HSABCt"	""	""	""	0
 "MAR11588"	"PCHOL2LINL_HSABCt"	""	""	""	""	""	""	""	"PCHOL2LINL_HSABCt"	"PCHOL2LINL_HSABCt"	""	""	""	0
 "MAR11589"	"PCHOL2OLE_HSABCt"	""	""	""	""	""	""	""	"PCHOL2OLE_HSABCt"	"PCHOL2OLE_HSABCt"	""	""	""	0
@@ -10239,29 +10163,25 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR11627"	"PEPALM_HSASBCt"	""	""	""	""	""	""	""	"PEPALM_HSASBCt"	"PEPALM_HSASBCt"	""	""	""	0
 "MAR11628"	"PESTE_HSABCt"	""	""	""	""	""	""	""	"PESTE_HSABCt"	"PESTE_HSABCt"	""	""	""	0
 "MAR11629"	"SPHMYLN_HsSECt"	""	""	""	""	""	""	""	"SPHMYLN_HsSECt"	"SPHMYLN_HsSECt"	""	""	""	0
-"MAR11630"	"SPHMYLN180241_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN180241_hs_SECt"	"SPHMYLN180241_hs_SECt"	""	""	""	0
-"MAR11631"	"SPHMYLN18114_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18114_hs_SECt"	"SPHMYLN18114_hs_SECt"	""	""	""	0
-"MAR11632"	"SPHMYLN18115_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18115_hs_SECt"	"SPHMYLN18115_hs_SECt"	""	""	""	0
-"MAR11633"	"SPHMYLN18116_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18116_hs_SECt"	"SPHMYLN18116_hs_SECt"	""	""	""	0
-"MAR11634"	"SPHMYLN181161_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN181161_hs_SECt"	"SPHMYLN181161_hs_SECt"	""	""	""	0
-"MAR11635"	"SPHMYLN18117_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18117_hs_SECt"	"SPHMYLN18117_hs_SECt"	""	""	""	0
-"MAR11636"	"SPHMYLN18118_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18118_hs_SECt"	"SPHMYLN18118_hs_SECt"	""	""	""	0
-"MAR11637"	"SPHMYLN181181_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN181181_hs_SECt"	"SPHMYLN181181_hs_SECt"	""	""	""	0
-"MAR11638"	"SPHMYLN18120_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18120_hs_SECt"	"SPHMYLN18120_hs_SECt"	""	""	""	0
-"MAR11639"	"SPHMYLN181201_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN181201_hs_SECt"	"SPHMYLN181201_hs_SECt"	""	""	""	0
-"MAR11640"	"SPHMYLN18121_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18121_hs_SECt"	"SPHMYLN18121_hs_SECt"	""	""	""	0
-"MAR11641"	"SPHMYLN18122_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18122_hs_SECt"	"SPHMYLN18122_hs_SECt"	""	""	""	0
-"MAR11642"	"SPHMYLN181221_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN181221_hs_SECt"	"SPHMYLN181221_hs_SECt"	""	""	""	0
-"MAR11643"	"SPHMYLN18123_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18123_hs_SECt"	"SPHMYLN18123_hs_SECt"	""	""	""	0
-"MAR11644"	"SPHMYLN1824_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN1824_hs_SECt"	"SPHMYLN1824_hs_SECt"	""	""	""	0
-"MAR11645"	"SPHMYLN1825_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN1825_hs_SECt"	"SPHMYLN1825_hs_SECt"	""	""	""	0
+"MAR11630"	"SPHMYLN180241_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN180241_hs_SECt;SPHMYLN180241_hs_t1"	"SPHMYLN180241_hs_SECt;SPHMYLN180241_hs_t1"	""	""	""	0
+"MAR11631"	"SPHMYLN18114_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18114_hs_SECt;SPHMYLN18114_hs_t1"	"SPHMYLN18114_hs_SECt;SPHMYLN18114_hs_t1"	""	""	""	0
+"MAR11632"	"SPHMYLN18115_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18115_hs_SECt;SPHMYLN18115_hs_t1"	"SPHMYLN18115_hs_SECt;SPHMYLN18115_hs_t1"	""	""	""	0
+"MAR11633"	"SPHMYLN18116_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18116_hs_SECt;SPHMYLN18116_hs_t1"	"SPHMYLN18116_hs_SECt;SPHMYLN18116_hs_t1"	""	""	""	0
+"MAR11634"	"SPHMYLN181161_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN181161_hs_SECt;SPHMYLN181161_hs_t1"	"SPHMYLN181161_hs_SECt;SPHMYLN181161_hs_t1"	""	""	""	0
+"MAR11635"	"SPHMYLN18117_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18117_hs_SECt;SPHMYLN18117_hs_t1"	"SPHMYLN18117_hs_SECt;SPHMYLN18117_hs_t1"	""	""	""	0
+"MAR11636"	"SPHMYLN18118_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18118_hs_SECt;SPHMYLN18118_hs_t1"	"SPHMYLN18118_hs_SECt;SPHMYLN18118_hs_t1"	""	""	""	0
+"MAR11637"	"SPHMYLN181181_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN181181_hs_SECt;SPHMYLN181181_hs_t1"	"SPHMYLN181181_hs_SECt;SPHMYLN181181_hs_t1"	""	""	""	0
+"MAR11638"	"SPHMYLN18120_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18120_hs_SECt;SPHMYLN18120_hs_t1"	"SPHMYLN18120_hs_SECt;SPHMYLN18120_hs_t1"	""	""	""	0
+"MAR11639"	"SPHMYLN181201_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN181201_hs_SECt;SPHMYLN181201_hs_t1"	"SPHMYLN181201_hs_SECt;SPHMYLN181201_hs_t1"	""	""	""	0
+"MAR11640"	"SPHMYLN18121_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18121_hs_SECt;SPHMYLN18121_hs_t1"	"SPHMYLN18121_hs_SECt;SPHMYLN18121_hs_t1"	""	""	""	0
+"MAR11641"	"SPHMYLN18122_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18122_hs_SECt;SPHMYLN18122_hs_t1"	"SPHMYLN18122_hs_SECt;SPHMYLN18122_hs_t1"	""	""	""	0
+"MAR11642"	"SPHMYLN181221_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN181221_hs_SECt;SPHMYLN181221_hs_t1"	"SPHMYLN181221_hs_SECt;SPHMYLN181221_hs_t1"	""	""	""	0
+"MAR11643"	"SPHMYLN18123_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN18123_hs_SECt;SPHMYLN18123_hs_t1"	"SPHMYLN18123_hs_SECt;SPHMYLN18123_hs_t1"	""	""	""	0
+"MAR11644"	"SPHMYLN1824_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN1824_hs_SECt;SPHMYLN1824_hs_t1"	"SPHMYLN1824_hs_SECt;SPHMYLN1824_hs_t1"	""	""	""	0
+"MAR11645"	"SPHMYLN1825_hs_SECt"	""	""	""	""	""	""	""	"SPHMYLN1825_hs_SECt;SPHMYLN1825_hs_t1"	"SPHMYLN1825_hs_SECt;SPHMYLN1825_hs_t1"	""	""	""	0
 "MAR11646"	"3AIBt1"	""	""	""	""	""	""	""	"3AIBt1"	"3AIBt1"	""	""	""	0
 "MAR11647"	"APRGSTRNt1e"	""	""	""	""	""	""	""	"APRGSTRNt1e"	"APRGSTRNt1e"	""	""	""	0
 "MAR11648"	"DIGALSGALSIDEATPte"	""	""	""	""	""	""	""	"DIGALSGALSIDEATPte"	"DIGALSGALSIDEATPte"	""	""	""	0
-"MAR11649"	""	""	""	""	""	""	""	""	"PAIL_hs_t1e"	"PAIL_hs_t1e"	""	""	""	0
-"MAR11650"	""	""	""	""	""	""	""	""	"PAILR_HSt1e"	"PAILR_HSt1e"	""	""	""	0
-"MAR11651"	""	""	""	""	""	""	""	""	"PAILPALM_HSt1e"	"PAILPALM_HSt1e"	""	""	""	0
-"MAR11652"	""	""	""	""	""	""	""	""	"PAILSTE_HSt1e"	"PAILSTE_HSt1e"	""	""	""	0
 "MAR11653"	"PCHOL2LINL_HSt1e"	""	""	""	""	""	""	""	"PCHOL2LINL_HSt1e"	"PCHOL2LINL_HSt1e"	""	""	""	0
 "MAR11654"	"PCHOL2OLE_HSt1e"	""	""	""	""	""	""	""	"PCHOL2OLE_HSt1e"	"PCHOL2OLE_HSt1e"	""	""	""	0
 "MAR11655"	"PCHOL2STE_HSt1e"	""	""	""	""	""	""	""	"PCHOL2STE_HSt1e"	"PCHOL2STE_HSt1e"	""	""	""	0
@@ -10306,39 +10226,22 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR11694"	"PESTE_HSt1e"	""	""	""	""	""	""	""	"PESTE_HSt1e"	"PESTE_HSt1e"	""	""	""	0
 "MAR11695"	"SPHMYLN_HsATPte"	""	""	""	""	""	""	""	"SPHMYLN_HsATPte"	"SPHMYLN_HsATPte"	""	""	""	0
 "MAR11696"	"SPHMYLN180241_hs_ATPt"	""	""	""	""	""	""	""	"SPHMYLN180241_hs_ATPt"	"SPHMYLN180241_hs_ATPt"	""	""	""	0
-"MAR11697"	""	""	""	""	""	""	""	""	"SPHMYLN180241_hs_t1"	"SPHMYLN180241_hs_t1"	""	""	""	0
 "MAR11698"	"SPHMYLN18114_hs_ATPt"	""	""	""	""	""	""	""	"SPHMYLN18114_hs_ATPt"	"SPHMYLN18114_hs_ATPt"	""	""	""	0
-"MAR11699"	""	""	""	""	""	""	""	""	"SPHMYLN18114_hs_t1"	"SPHMYLN18114_hs_t1"	""	""	""	0
 "MAR11700"	"SPHMYLN18115_hs_ATPt"	""	""	""	""	""	""	""	"SPHMYLN18115_hs_ATPt"	"SPHMYLN18115_hs_ATPt"	""	""	""	0
-"MAR11701"	""	""	""	""	""	""	""	""	"SPHMYLN18115_hs_t1"	"SPHMYLN18115_hs_t1"	""	""	""	0
 "MAR11702"	"SPHMYLN18116_hs_ATPt"	""	""	""	""	""	""	""	"SPHMYLN18116_hs_ATPt"	"SPHMYLN18116_hs_ATPt"	""	""	""	0
-"MAR11703"	""	""	""	""	""	""	""	""	"SPHMYLN18116_hs_t1"	"SPHMYLN18116_hs_t1"	""	""	""	0
 "MAR11704"	"SPHMYLN181161_hs_ATPt"	""	""	""	""	""	""	""	"SPHMYLN181161_hs_ATPt"	"SPHMYLN181161_hs_ATPt"	""	""	""	0
-"MAR11705"	""	""	""	""	""	""	""	""	"SPHMYLN181161_hs_t1"	"SPHMYLN181161_hs_t1"	""	""	""	0
 "MAR11706"	"SPHMYLN18117_hs_ATPt"	""	""	""	""	""	""	""	"SPHMYLN18117_hs_ATPt"	"SPHMYLN18117_hs_ATPt"	""	""	""	0
-"MAR11707"	""	""	""	""	""	""	""	""	"SPHMYLN18117_hs_t1"	"SPHMYLN18117_hs_t1"	""	""	""	0
 "MAR11708"	"SPHMYLN18118_hs_ATPt"	""	""	""	""	""	""	""	"SPHMYLN18118_hs_ATPt"	"SPHMYLN18118_hs_ATPt"	""	""	""	0
-"MAR11709"	""	""	""	""	""	""	""	""	"SPHMYLN18118_hs_t1"	"SPHMYLN18118_hs_t1"	""	""	""	0
 "MAR11710"	"SPHMYLN181181_hs_ATPt"	""	""	""	""	""	""	""	"SPHMYLN181181_hs_ATPt"	"SPHMYLN181181_hs_ATPt"	""	""	""	0
-"MAR11711"	""	""	""	""	""	""	""	""	"SPHMYLN181181_hs_t1"	"SPHMYLN181181_hs_t1"	""	""	""	0
 "MAR11712"	"SPHMYLN18120_hs_ATPt"	""	""	""	""	""	""	""	"SPHMYLN18120_hs_ATPt"	"SPHMYLN18120_hs_ATPt"	""	""	""	0
-"MAR11713"	""	""	""	""	""	""	""	""	"SPHMYLN18120_hs_t1"	"SPHMYLN18120_hs_t1"	""	""	""	0
 "MAR11714"	"SPHMYLN181201_hs_ATPt"	""	""	""	""	""	""	""	"SPHMYLN181201_hs_ATPt"	"SPHMYLN181201_hs_ATPt"	""	""	""	0
-"MAR11715"	""	""	""	""	""	""	""	""	"SPHMYLN181201_hs_t1"	"SPHMYLN181201_hs_t1"	""	""	""	0
 "MAR11716"	"SPHMYLN18121_hs_ATPt"	""	""	""	""	""	""	""	"SPHMYLN18121_hs_ATPt"	"SPHMYLN18121_hs_ATPt"	""	""	""	0
-"MAR11717"	""	""	""	""	""	""	""	""	"SPHMYLN18121_hs_t1"	"SPHMYLN18121_hs_t1"	""	""	""	0
 "MAR11718"	"SPHMYLN18122_hs_ATPt"	""	""	""	""	""	""	""	"SPHMYLN18122_hs_ATPt"	"SPHMYLN18122_hs_ATPt"	""	""	""	0
-"MAR11719"	""	""	""	""	""	""	""	""	"SPHMYLN18122_hs_t1"	"SPHMYLN18122_hs_t1"	""	""	""	0
 "MAR11720"	"SPHMYLN181221_hs_ATPt"	""	""	""	""	""	""	""	"SPHMYLN181221_hs_ATPt"	"SPHMYLN181221_hs_ATPt"	""	""	""	0
-"MAR11721"	""	""	""	""	""	""	""	""	"SPHMYLN181221_hs_t1"	"SPHMYLN181221_hs_t1"	""	""	""	0
 "MAR11722"	"SPHMYLN18123_hs_ATPt"	""	""	""	""	""	""	""	"SPHMYLN18123_hs_ATPt"	"SPHMYLN18123_hs_ATPt"	""	""	""	0
-"MAR11723"	""	""	""	""	""	""	""	""	"SPHMYLN18123_hs_t1"	"SPHMYLN18123_hs_t1"	""	""	""	0
 "MAR11724"	"SPHMYLN1824_hs_ATPt"	""	""	""	""	""	""	""	"SPHMYLN1824_hs_ATPt"	"SPHMYLN1824_hs_ATPt"	""	""	""	0
-"MAR11725"	""	""	""	""	""	""	""	""	"SPHMYLN1824_hs_t1"	"SPHMYLN1824_hs_t1"	""	""	""	0
 "MAR11726"	"SPHMYLN1825_hs_ATPt"	""	""	""	""	""	""	""	"SPHMYLN1825_hs_ATPt"	"SPHMYLN1825_hs_ATPt"	""	""	""	0
-"MAR11727"	""	""	""	""	""	""	""	""	"SPHMYLN1825_hs_t1"	"SPHMYLN1825_hs_t1"	""	""	""	0
-"MAR11728"	""	""	""	""	""	""	""	""	"2HXIC_Lt1e"	"2HXIC_Lt1e"	""	""	""	0
-"MAR11729"	""	""	""	""	""	""	""	""	"2HXIC_Lt2e"	"2HXIC_Lt2e"	""	""	""	0
+"MAR11728"	""	""	""	""	""	""	""	""	"2HXIC_Lt1e;2HXIC_Lt2e"	"2HXIC_Lt1e;2HXIC_Lt2e"	""	""	""	0
 "MAR11730"	""	""	""	""	""	""	""	""	"EX_2hxic_L[e]"	"EX_2hxic_L[e]"	""	""	""	0
 "MAR11731"	"2HYDOGOAT3t"	""	""	""	""	""	""	""	"2HYDOGOAT3t"	"2HYDOGOAT3t"	""	""	""	0
 "MAR11732"	""	""	""	""	""	""	""	""	"EX_2hydog[e]"	"EX_2hydog[e]"	""	""	""	0
@@ -10587,21 +10490,16 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR11983"	"EX_idl_hs_e"	""	""	""	""	""	""	""	"EX_idl_hs[e]"	"EX_idl_hs[e]"	""	""	""	0
 "MAR11984"	"EX_ldl_hs_e"	""	""	""	""	""	""	""	"EX_ldl_hs[e]"	"EX_ldl_hs[e]"	""	""	""	0
 "MAR11985"	"EX_hdl_hs_e"	""	""	""	""	""	""	""	"EX_hdl_hs[e]"	"EX_hdl_hs[e]"	""	""	""	0
-"MAR11986"	""	""	""	""	""	""	""	""	"HC00005te"	"HC00005te"	""	""	""	0
+"MAR11986"	""	""	""	""	""	""	""	""	"HC00005te;HC00005t1e"	"HC00005te;HC00005t1e"	""	""	""	0
 "MAR11987"	"EX_HC00005_e"	""	""	""	""	""	""	""	"EX_HC00005[e]"	"EX_HC00005[e]"	""	""	""	0
-"MAR11988"	""	""	""	""	""	""	""	""	"HC00005t1e"	"HC00005t1e"	""	""	""	0
-"MAR11989"	""	""	""	""	""	""	""	""	"HC00006te"	"HC00006te"	""	""	""	0
+"MAR11989"	""	""	""	""	""	""	""	""	"HC00006te;HC00006t1e"	"HC00006te;HC00006t1e"	""	""	""	0
 "MAR11990"	"EX_HC00006_e"	""	""	""	""	""	""	""	"EX_HC00006[e]"	"EX_HC00006[e]"	""	""	""	0
-"MAR11991"	""	""	""	""	""	""	""	""	"HC00006t1e"	"HC00006t1e"	""	""	""	0
-"MAR11992"	""	""	""	""	""	""	""	""	"HC00007te"	"HC00007te"	""	""	""	0
+"MAR11992"	""	""	""	""	""	""	""	""	"HC00007te;HC00007t1e"	"HC00007te;HC00007t1e"	""	""	""	0
 "MAR11993"	"EX_HC00007_e"	""	""	""	""	""	""	""	"EX_HC00007[e]"	"EX_HC00007[e]"	""	""	""	0
-"MAR11994"	""	""	""	""	""	""	""	""	"HC00007t1e"	"HC00007t1e"	""	""	""	0
-"MAR11995"	""	""	""	""	""	""	""	""	"HC00008te"	"HC00008te"	""	""	""	0
+"MAR11995"	""	""	""	""	""	""	""	""	"HC00008te;HC00008t1e"	"HC00008te;HC00008t1e"	""	""	""	0
 "MAR11996"	"EX_HC00008_e"	""	""	""	""	""	""	""	"EX_HC00008[e]"	"EX_HC00008[e]"	""	""	""	0
-"MAR11997"	""	""	""	""	""	""	""	""	"HC00008t1e"	"HC00008t1e"	""	""	""	0
-"MAR11998"	""	""	""	""	""	""	""	""	"HC00009te"	"HC00009te"	""	""	""	0
+"MAR11998"	""	""	""	""	""	""	""	""	"HC00009te;HC00009t1e"	"HC00009te;HC00009t1e"	""	""	""	0
 "MAR11999"	"EX_HC00009_e"	""	""	""	""	""	""	""	"EX_HC00009[e]"	"EX_HC00009[e]"	""	""	""	0
-"MAR12000"	""	""	""	""	""	""	""	""	"HC00009t1e"	"HC00009t1e"	""	""	""	0
 "MAR12001"	"DOPASULT4"	""	""	""	""	""	""	""	"DOPASULT4"	"DOPASULT4"	""	""	""	0
 "MAR12002"	"UDPG4DOPA"	""	""	""	""	""	""	""	"UDPG4DOPA"	"UDPG4DOPA"	""	""	""	0
 "MAR12003"	"UDPG3DOPA"	""	""	""	""	""	""	""	"UDPG3DOPA"	"UDPG3DOPA"	""	""	""	0
@@ -10612,7 +10510,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR12009"	"EX_dopa4glcur_e"	""	""	""	""	""	""	""	"EX_dopa4glcur[e]"	"EX_dopa4glcur[e]"	""	""	""	0
 "MAR12010"	"DOPA3GLCURt"	""	""	""	""	""	""	""	"DOPA3GLCURt"	"DOPA3GLCURt"	""	""	""	0
 "MAR12011"	"EX_dopa3glcur_e"	""	""	""	""	""	""	""	"EX_dopa3glcur[e]"	"EX_dopa3glcur[e]"	""	""	""	0
-"MAR12012"	"DOPACHRMDC"	""	""	""	""	""	""	""	"DOPACHRMDC"	"DOPACHRMDC"	""	""	""	0
+"MAR12012"	"DOPACHRMDC"	""	"HMR_9733"	""	"R03674"	"MNXR108330"	""	"RCR14346"	"DOPACHRMDC;HMR_9733"	"DOPACHRMDC;HMR_9733;MAR09733"	""	""	""	0
 "MAR12013"	"CE5026t"	""	""	""	""	""	""	""	"CE5026t"	"CE5026t"	""	""	""	0
 "MAR12014"	"GGTe_1"	""	""	""	""	""	""	""	"GGTe_1"	"GGTe_1"	""	""	""	0
 "MAR12015"	"CYSGLYPTASEe_1"	""	""	""	""	""	""	""	"CYSGLYPTASEe_1"	"CYSGLYPTASEe_1"	""	""	""	0
@@ -11622,7 +11520,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR13061"	"EX_M03045_e"	""	""	""	""	""	""	""	"EX_M03045[e]"	"EX_M03045[e]"	""	""	""	0
 "MAR13062"	"EX_M03051_e"	""	""	""	""	""	""	""	"EX_M03051[e]"	"EX_M03051[e]"	""	""	""	0
 "MAR13063"	"EX_M03153_e"	""	""	""	""	""	""	""	"EX_M03153[e]"	"EX_M03153[e]"	""	""	""	0
-"MAR13064"	""	""	""	""	""	""	""	""	"EX_M01268[e]"	"EX_M01268[e]"	""	""	""	0
 "MAR13065"	""	""	""	""	""	""	""	""	"EX_HC02080[e]"	"EX_HC02080[e]"	""	""	""	0
 "MAR13067"	"EX_M02837_e"	""	""	""	""	""	""	""	"EX_M02837[e]"	"EX_M02837[e]"	""	""	""	0
 "MAR13068"	""	""	""	""	""	""	""	""	"EX_M02382[e]"	"EX_M02382[e]"	""	""	""	0
@@ -11641,7 +11538,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR13081"	"CYOOm3i"	""	""	""	""	""	""	""	"CYOOm3i"	"CYOOm3i"	""	""	""	0
 "MAR10023"	""	""	""	""	""	""	""	""	""	"HMR_10023"	""	""	""	0
 "MAR10024"	""	""	""	""	""	""	""	""	""	"HMR_10024"	""	""	""	0
-"MAR10025"	""	""	""	""	""	""	""	""	""	"HMR_10025"	""	""	""	0
 "MAR10026"	""	""	""	""	""	""	""	""	""	"HMR_10026"	""	""	""	0
 "MAR10027"	""	""	""	""	""	""	""	""	""	"HMR_10027"	""	""	""	0
 "MAR10028"	""	""	""	""	""	""	""	""	""	"HMR_10028"	""	""	""	0
@@ -11749,7 +11645,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR13085"	""	""	""	""	""	""	""	""	""	""	""	""	""	0
 "MAR13086"	""	""	""	""	""	""	""	""	""	""	""	""	""	0
 "MAR20001"	"HMR_6633;RDH1;R_HMR_6633;R_RDH1;R_TRETINOLOR1;TRETINOLOR1"	""	""	""	"R02124"	"MNXR189842"	""	""	""	""	"RHEA:21284"	""	""	0
-"MAR20002"	"HMR_6633;RDH1;R_HMR_6633;R_RDH1;R_TRETINOLOR1;TRETINOLOR1"	""	""	""	"R02124"	"MNXR189842"	""	""	""	""	"RHEA:21284"	""	""	0
 "MAR20003"	"RDH2;R_RDH2"	""	""	""	"R08382"	"MNXR103441"	""	""	""	""	"RHEA:42052"	""	""	0
 "MAR20005"	""	""	""	""	""	"MNXR167709"	""	""	""	""	"RHEA:39803"	""	""	0
 "MAR20006"	""	""	""	""	""	"MNXR167709"	""	""	""	""	"RHEA:39803"	""	""	0
@@ -11760,7 +11655,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR20013"	""	""	""	""	"R03225"	"MNXR108031"	""	""	""	""	"RHEA:23048"	""	""	0
 "MAR20016"	"ALDD16;R_ALDD16"	""	""	""	"R01704"	"MNXR95739"	""	""	""	""	"RHEA:33739"	""	""	0
 "MAR20017"	"ALDD8;R_ALDD8"	""	""	""	""	"MNXR95760"	""	""	""	""	"RHEA:44100"	""	""	0
-"MAR20020"	"G6PP;G6PPer;R_G6PP;R_G6PPer"	""	""	""	"R00303"	"MNXR195425"	""	""	""	""	"RHEA:16689"	""	""	0
 "MAR20033"	"GALM2;GALM2pp;R_GALM2;R_GALM2pp"	""	""	""	"R10619"	"MNXR153745"	""	""	""	""	"RHEA:28675"	""	""	0
 "MAR20034"	"GALM2;GALM2pp;R_GALM2;R_GALM2pp"	""	""	""	"R10619"	"MNXR153745"	""	""	""	""	"RHEA:28675"	""	""	0
 "MAR20035"	"A1E;GalMr;R_A1E;R_GalMr"	""	""	""	"R01602"	"MNXR107082"	""	""	""	""	"RHEA:10264"	""	""	0
@@ -11792,7 +11686,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR20063"	"ALDD7;R_ALDD7"	""	""	""	""	"MNXR95759"	""	""	""	""	"RHEA:44108"	""	""	0
 "MAR20064"	""	""	""	""	"R08146"	"MNXR111724"	""	""	""	""	"RHEA:24216"	""	""	0
 "MAR20065"	""	""	""	""	"R08146"	"MNXR111724"	""	""	""	""	"RHEA:24216"	""	""	0
-"MAR20066"	"CAT;CATm;CATp;CATpp;CATr;R_CAT;R_CATm;R_CATp;R_CATpp;R_CATr"	""	""	""	"R00009"	"MNXR96455"	""	""	""	""	"RHEA:20309"	""	""	0
 "MAR20069"	""	""	""	""	""	""	""	""	""	""	""	""	""	0
 "MAR20070"	""	""	""	""	""	""	""	""	""	""	""	""	""	0
 "MAR20071"	""	""	""	""	"R00490"	"MNXR165843"	""	""	""	""	"RHEA:16962"	""	""	0
@@ -11813,6 +11706,9 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR20108"	"HBZOPT10m;R_HBZOPT10m"	""	""	""	""	"MNXR100567"	""	""	""	""	"RHEA:44564"	""	""	0
 "MAR20109"	"HBZOPT10m;R_HBZOPT10m"	""	""	""	""	"MNXR100567"	""	""	""	""	"RHEA:44564"	""	""	0
 "MAR20110"	""	""	""	""	""	"MNXR102097"	""	""	""	""	"RHEA:15642"	"RHEA:15641"	""	0
+"MAR20112"	""	""	""	""	"R04385"	"MNXR96330"	""	""	""	""	""	"RHEA:13501"	""	0
+"MAR20113"	""	""	""	""	""	""	""	""	""	""	""	""	""	0
+"MAR20114"	""	""	""	""	""	""	""	""	""	""	""	""	""	0
 "MAR15001"	""	""	""	""	"R01465"	"MNXR103402"	"R-HSA-6798667"	""	""	""	""	""	""	0
 "MAR15003"	""	""	""	""	"R06171"	"MNXR104834"	""	""	""	""	""	""	""	0
 "MAR15004"	""	""	""	""	"R06601"	"MNXR100652"	""	""	""	""	""	""	""	0
@@ -11844,20 +11740,23 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR15053"	""	""	""	""	"R03738"	"MNXR108386"	""	""	""	""	""	""	""	0
 "MAR15054"	""	""	""	""	"R11916"	"MNXR170522"	""	""	""	""	""	""	""	0
 "MAR15055"	""	""	""	""	"R03984"	"MNXR152018"	""	""	""	""	""	""	""	0
-"MAR00113"	"C3STDH1Pr"	""	""	""	""	"MNXR95038"	""	""	"C3STDH1Pr"	"C3STDH1Pr"	""	""	""	0
-"MAR00222"	"DHCR243r"	""	""	""	""	"MNXR97382"	""	""	"DHCR243r"	"DHCR243r"	""	""	""	0
-"MAR00443"	"EBP1r"	""	""	""	""	"MNXR96689"	""	""	"EBP1r"	"EBP1r"	""	""	""	0
+"MAR03931"	"TRDR"	"R02016C"	"HMR_3931"	"r0469"	"R02016"	"MNXR104766"	""	"RCR11151"	"TRDR"	"HMR_3931"	""	"RHEA:20345"	""	0
+"MAR01557"	"LSTO2r"	""	"HMR_1557"	"r0793"	"R07215"	"MNXR101245;MNXR110903"	""	"RCR10173"	"HMR_1557"	"HMR_1557"	""	"RHEA:46556"	""	0
+"MAR00114"	"C3STDH1r"	""	""	""	""	"MNXR96410"	""	""	"C3STDH1r"	"C3STDH1r"	""	""	""	0
 "MAR01498"	"LNSTLSr"	""	""	""	""	"MNXR101117"	""	""	"LNSTLSr"	"LNSTLSr"	""	""	""	0
-"MAR01508"	"LSTO1r"	""	""	""	""	"MNXR101244"	""	""	"LSTO1r"	"LSTO1r"	""	""	""	0
 "MAR01714"	"SQLEr"	""	""	""	""	"MNXR104447"	""	""	"SQLEr"	"SQLEr"	""	""	""	0
 "MAR01715"	"SQLSr"	""	""	""	""	"MNXR104529"	""	""	"SQLSr"	"SQLSr"	""	""	""	0
 "MAR02200"	"LNS14DMr"	""	""	""	""	"MNXR101115"	""	""	"r0781"	"r0781"	""	""	""	0
 "MAR02301"	"r1135"	""	""	""	""	""	""	""	"r1135"	"r1135"	""	""	""	0
+"MAR02337"	"r1380"	""	""	""	""	"MNXR105284"	""	""	"r1380"	"r1380"	""	""	""	0
+"MAR02339"	"EBP2r"	""	""	""	""	"MNXR96687"	""	""	"EBP2r;r1381"	"r1381"	""	""	""	0
 "MAR05151"	""	""	"HMR_5151"	"r1092"	""	""	""	"RCR14453"	"HMR_5151;r1092"	"HMR_5151"	""	""	""	0
-"MAR04497"	""	""	"HMR_4497"	"r0365"	"R01608"	"MNXR94902"	""	"RCR10463"	"r0365"	"HMR_4497"	""	"RHEA:13357"	""	0
+"MAR04106"	"MCDm"	""	"HMR_4106"	"r0064"	"R00233"	"MNXR101412"	""	"RCR11089"	"MCDm"	"HMR_4106"	"RHEA:18782"	"RHEA:18781"	""	0
 "MAR04861"	"INSTt2"	""	"HMR_4861"	"r0827"	""	"MNXR100841"	""	"RCR40440"	""	"HMR_4861"	"RHEA:60367"	"RHEA:60364"	""	0
+"MAR04485"	"TMDPP"	"R01570C"	"HMR_4485"	"r0352"	"R01570"	"MNXR104887"	""	"RCR11165"	"TMDPP"	"HMR_4485"	"RHEA:16040"	"RHEA:16037"	""	0
 "MAR06981"	"R_TMABADH;TMABADH"	""	"HMR_6981"	""	"R03283"	"MNXR108074;MNXR104876"	""	"RCR11344"	"TMABADH"	"HMR_6981"	""	"RHEA:17985"	""	0
 "MAR02365"	""	""	"HMR_2365"	""	""	""	""	"RCR11905"	"HMR_2365"	"HMR_2365"	""	""	""	0
+"MAR02472"	"HMR_2472"	"RE3109C"	"HMR_2472"	""	""	""	""	"RCR11948"	"HMR_2472"	"HMR_2472"	""	""	""	0
 "MAR02505"	""	"RE3135C"	"HMR_2505"	""	""	""	""	"RCR10166"	"DESAT24_1"	"HMR_2505"	""	""	""	0
 "MAR06634"	""	""	"HMR_6634"	""	""	""	""	"RCR13883"	"HMR_6634"	"HMR_6634"	""	""	""	0
 "MAR06641"	""	"RE1938C"	"HMR_6641"	""	""	"MNXR103582"	""	"RCR13887"	"RE1938C"	"HMR_6641"	""	""	""	0
@@ -11884,5 +11783,4 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR06476"	""	"RE2387C"	"HMR_6476"	""	""	"MNXR103665"	""	"RCR14010"	"RE2387C"	"HMR_6476"	""	""	""	0
 "MAR06478"	""	"RE2383C"	"HMR_6478"	""	""	"MNXR103662"	""	"RCR14012"	"RE2383C"	"HMR_6478"	""	""	""	0
 "MAR08614"	"CBLATm"	""	"HMR_8614"	""	""	"MNXR96476"	""	"RCR20663"	"CBL2tm"	"HMR_8614"	""	""	""	0
-"MAR00145"	"DESAT18_10"	""	""	""	""	"MNXR97241"	""	""	"DESAT18_10"	"DESAT18_10"	""	""	""	0
-"MAR00151"	"DESAT18_8"	""	""	""	""	"MNXR97248"	""	""	"DESAT18_8"	"DESAT18_8"	""	""	""	0
+"MAR00149"	"DESAT18_6"	""	""	""	""	"MNXR97246"	""	""	"DESAT18_6"	"DESAT18_6"	""	""	""	0