diff --git a/pyproject.toml b/pyproject.toml
index e62b3eb1..ce770110 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -54,7 +54,7 @@ dependencies = [
     'graphtools>=1.5',
     'phate>=1.0',
     'tqdm>=4.64',
-    'pydeseq2>=0.3, <=0.4.0',
+    'pydeseq2>=0.3',
     'mofax>=0.3',
     'adjustText>=0.8',
     'scikit-misc>=0.1',