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Figure3_data.txt
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Exposure Variable_type R2_main R2_interaction R2_diff Interaction_Beta Interaction_SE Interaction_P PRS_beta PRS_SE N Ancestry Cohort interaction_beta_div_prs_beta Units Original Note
Age Continuous 0.04487 0.04925 0.00438 0.001492156 0.000521053 4.24E-03 0.026552947 0.036959081 1789 AFR GERA 0.056195495
Age Continuous 0.0659 0.06595 5.00E-05 -1.14E-04 2.76E-04 6.80E-01 5.19E-02 1.53E-02 3103 AFR eMERGE -0.002196532
Age Continuous 0.07053 0.07053 0 -1.06E-05 2.55E-04 9.67E-01 0.03139526 1.34E-02 7033 AFR UKBB -0.00033664
Age Continuous 0.07846 0.08066 0.0022 -0.000728676 0.000151832 1.62E-06 0.085716029 0.00822719 9674 AFR PMBB -0.008501047
Age Continuous 0.08776 0.08982 0.00206 -0.000588931 7.61E-05 1.05E-14 0.091654584 4.56E-03 26372 EUR PMBB -0.006425549
Age Continuous 0.09454 0.1003 0.00576 -0.00104439 7.32E-05 5.40E-46 0.125465951 4.74E-03 31961 EUR eMERGE -0.008324091
Age Continuous 0.07059 0.0716 0.00101 -0.000847309 0.000108447 5.68E-15 0.13073658 0.006930783 56049 EUR GERA -0.00648104
Age Continuous 0.09041 0.09102 0.00061 -0.000516409 3.24E-05 3.60E-57 0.074848838 1.86E-03 376729 EUR UKBB -0.006899359
AlcoholDaysPerWeek Continuous 0.05584 0.056 0.00016 -3.21E-03 0.00791859 6.85E-01 3.62E-02 1031 AFR UKBB -0.088702771 SD DrinkFreqWkRaw
AlcoholDaysPerWeek Continuous 0.06854 0.07147 0.00293 0.048862394 0.02122693 2.15E-02 0.383002323 1699 AFR GERA 0.127577278 SD
AlcoholDaysPerWeek Continuous 0.09999 0.1015 0.00151 -0.033741567 0.003716163 1.12E-19 0.243527625 54326 EUR GERA -0.138553345 SD
AlcoholDaysPerWeek Continuous 0.1049 0.1073 0.0024 -8.17E-03 5.21E-04 2.62E-55 4.10E-02 122281 EUR UKBB -0.199584726 SD DrinkFreqWkRaw
DBP Continuous 0.1304 0.1305 0.0001 7.89E-05 1.62E-04 6.27E-01 2.03E-02 1.48E-02 6784 AFR UKBB 0.0038867 DBPadj
DBP Continuous 0.09057 0.09064 7.00E-05 -0.000172949 0.000210791 4.12E-01 0.061480048 0.016758661 9651 AFR PMBB -0.002813091
DBP Continuous 0.1062 0.1065 0.0003 0.000352336 1.12E-04 1.62E-03 0.0311798 8.69E-03 26294 EUR PMBB 0.011300137
DBP Continuous 0.188 0.1887 0.0007 0.000408053 2.50E-05 6.06E-60 0.007956813 2.35E-03 352804 EUR UKBB 0.051283472 DBPadj
HbA1c Continuous 0.1199 0.121 0.0011 -0.00041865 0.000191479 2.89E-02 0.062887857 0.013535776 3531 AFR PMBB -0.006657088
HbA1c Continuous 0.09882 0.09957 0.00075 -4.50E-04 0.000221608 4.26E-02 4.87E-02 0.009720112 5703 AFR UKBB -0.009240246
HbA1c Continuous 0.1197 0.1199 0.0002 -4.23E-05 0.000184671 8.19E-01 0.051882266 0.012341941 6517 EUR PMBB -0.000814444
HbA1c Continuous 0.1375 0.1377 0.0002 0.000329302 4.38E-05 5.37E-14 0.031888121 1.87E-03 358798 EUR UKBB 0.010326792
HDL Continuous 0.1232 0.125 0.0018 -2.24E-04 2.25E-04 3.19E-01 1.58E-02 1.98E-02 3103 AFR eMERGE -0.014177215
HDL Continuous 0.147 0.1474 0.0004 2.29E-04 0.0001458 1.17E-01 2.53E-02 0.011775534 6100 AFR UKBB 0.009051383
HDL Continuous 0.1465 0.1465 0 0.000113451 0.000182231 5.34E-01 0.042116811 0.016085865 7015 AFR PMBB 0.002693722
HDL Continuous 0.1631 0.1634 0.0003 -0.000199827 9.71E-05 3.97E-02 0.069457064 8.07E-03 14422 EUR PMBB -0.002876986
HDL Continuous 0.1798 0.1804 0.0006 -2.91E-04 6.25E-05 3.12E-06 6.46E-02 4.64E-03 31952 EUR eMERGE -0.004504644
HDL Continuous 0.2169 0.2181 0.0012 -0.000414342 1.99E-05 1.71E-96 0.063329568 1.15E-03 328719 EUR UKBB -0.006542631
LDL Continuous 0.0731 0.07352 0.00042 5.57E-05 1.24E-04 6.53E-01 3.35E-02 1.39E-02 3103 AFR eMERGE 0.001662687
LDL Continuous 0.07476 0.07501 0.00025 8.07E-05 6.48E-05 2.13E-01 2.14E-02 8.42E-03 6581 AFR UKBB 0.003771028
LDL Continuous 0.09851 0.099 0.00049 -0.000155229 7.96E-05 5.11E-02 0.063545578 8.50E-03 7013 AFR PMBB -0.002442798
LDL Continuous 0.08063 0.08064 1.00E-05 -2.29E-05 4.83E-05 6.35E-01 5.87E-02 5.32E-03 14288 EUR PMBB -0.000390119
LDL Continuous 0.09462 0.09469 7.00E-05 -3.09E-05 3.18E-05 3.31E-01 6.59E-02 4.06E-03 31961 EUR eMERGE -0.000468892
LDL Continuous 0.09291 0.09349 0.00058 -0.000127504 8.46E-06 2.63E-51 0.061157267 1.11E-03 358556 EUR UKBB -0.002084854
PhysicalActivity Continuous 0.06991 0.07223 0.00232 -0.005142041 0.021515567 8.11E-01 0.535808773 1747 AFR GERA -0.009596784 SD
PhysicalActivity Continuous 0.06941 0.07018 0.00077 -3.02E-03 0.002122527 1.55E-01 3.90E-02 5352 AFR UKBB -0.077435897 SD PhysicalActivity
PhysicalActivity Continuous 0.1013 0.1024 0.0011 -0.028742124 0.003640856 2.97E-15 0.188766554 54845 EUR GERA -0.1522628 SD
PhysicalActivity Continuous 0.1089 0.1099 0.001 -0.004947182 2.91E-04 8.92E-65 0.043361755 304951 EUR UKBB -0.114090908 SD PhysicalActivity
Sex Binary 0.04487 0.04859 0.00372 0.039143408 0.014835823 8.40E-03 0.101519251 0.020088323 1789 AFR GERA 0.38557621
Sex Binary 0.0659 0.06716 0.00126 -1.85E-02 0.009072803 4.12E-02 5.18E-02 0.005163044 3103 AFR eMERGE -0.357142857
Sex Binary 0.07053 0.07243 0.0019 -0.015341602 4.05E-03 1.52E-04 0.037289791 2.70E-03 7033 AFR UKBB -0.411415607
Sex Binary 0.07846 0.07922 0.00076 -0.014224225 0.005037428 4.76E-03 0.053314589 0.003084111 9674 AFR PMBB -0.266797987
Sex Binary 0.08776 0.08921 0.00145 -0.015907101 2.45E-03 9.26E-11 0.066379686 1.82E-03 26372 EUR PMBB -0.239638087
Sex Binary 0.09454 0.09667 0.00213 -0.019501488 2.24E-03 3.86E-18 0.068515525 1.51E-03 31961 EUR eMERGE -0.284628747
Sex Binary 0.07059 0.07094 0.00035 -0.01231147 0.00267408 4.15E-06 0.08266092 0.001721808 56049 EUR GERA -0.148939426
Sex Binary 0.09041 0.09066 0.00025 -0.005280768 5.16E-04 1.41E-24 0.047905635 3.52E-04 376729 EUR UKBB -0.110232711
SmokingPackYears Continuous 0.07067 0.07081 0.00014 1.77E-04 0.000422457 6.75E-01 2.77E-02 0.008071649 1147 AFR UKBB 0.006389892
SmokingPackYears Continuous 0.05001 0.051 0.00099 0.001135015 0.000989126 2.51E-01 0.133727937 0.043491296 1662 AFR GERA 0.008487494
SmokingPackYears Continuous 0.08085 0.08088 3.00E-05 -8.65E-05 0.000135438 5.23E-01 8.63E-02 0.00756143 53213 EUR GERA -0.001002317
SmokingPackYears Continuous 0.1055 0.1057 0.0002 1.28E-04 2.46E-05 2.14E-07 4.26E-02 7.41E-04 114135 EUR UKBB 0.003004695
Socioeconomic Continuous 0.05704 0.05806 0.00102 -0.026871894 0.022719282 2.37E-01 0.437515044 1660 AFR GERA -0.06141936 SD Income
Socioeconomic Continuous 0.07448 0.07471 0.00023 0.002516084 2.01E-03 2.12E-01 0.03674342 7018 AFR UKBB -0.068477131 SD Townsend Reversed effect direction
Socioeconomic Continuous 0.07918 0.07937 0.00019 0.004005396 0.003828223 2.95E-01 0.392271651 51661 EUR GERA 0.010210771 SD Income
Socioeconomic Continuous 0.09931 0.1002 0.00089 0.004413383 2.74E-04 2.86E-58 0.065126704 376283 EUR UKBB -0.067766104 SD Townsend Reversed effect direction
TG Continuous 0.07605 0.07612 7.00E-05 1.48E-06 6.36E-05 9.81E-01 4.55E-02 8.19E-03 3102 AFR eMERGE 3.25E-05
TG Continuous 0.1097 0.1106 0.0009 -6.15E-05 2.87E-05 3.19E-02 4.05E-02 4.39E-03 6592 AFR UKBB -0.001519849
TG Continuous 0.09926 0.09938 0.00012 2.42E-05 2.53E-05 3.38E-01 4.48E-02 5.03E-03 7155 AFR PMBB 0.000540179
TG Continuous 0.1151 0.1163 0.0012 -7.09E-05 1.56E-05 5.46E-06 6.68E-02 3.29E-03 15079 EUR PMBB -0.001061377
TG Continuous 0.1356 0.1359 0.0003 -4.11E-05 1.18E-05 5.01E-04 6.42E-02 2.08E-03 31939 EUR eMERGE -0.000640187
TG Continuous 0.1733 0.1733 0 -2.10E-06 3.07E-06 4.95E-01 4.49E-02 7.22E-04 358933 EUR UKBB -4.67E-05
TotCholesterol Continuous 0.06597 0.06742 0.00145 -1.31E-05 1.03E-04 8.99E-01 2.09E-02 2.08E-02 3103 AFR eMERGE -0.000626794
TotCholesterol Continuous 0.07203 0.07227 0.00024 6.50E-05 4.96E-05 1.91E-01 2.01E-02 1.04E-02 6594 AFR UKBB 0.003232438
TotCholesterol Continuous 0.09642 0.09712 0.0007 -0.000157217 6.76E-05 2.00E-02 0.0716584 1.28E-02 7040 AFR PMBB -0.002193979
TotCholesterol Continuous 0.08008 0.0801 2.00E-05 -2.49E-05 3.90E-05 5.22E-01 6.04E-02 8.06E-03 14417 EUR PMBB -0.000412252
TotCholesterol Continuous 0.09522 0.09533 0.00011 -5.11E-05 2.60E-05 4.96E-02 6.79E-02 5.74E-03 31961 EUR eMERGE -0.000752577
TotCholesterol Continuous 0.09096 0.09178 0.00082 -1.17E-04 6.54E-06 1.64E-71 6.67E-02 1.35E-03 359221 EUR UKBB -0.001755334