From 19c4bae1519748674aea19228a7f7e7c11c86ef1 Mon Sep 17 00:00:00 2001 From: Karin Slater Date: Thu, 11 Jan 2024 16:32:14 +0000 Subject: [PATCH] revert import updates [#188] --- rbo-base.owl | 22 +- rbo-full.owl | 894 +- rbo.owl | 756 +- src/ontology/components/all_templates.owl | 12 +- src/ontology/imports/bfo_import.owl | 4 +- src/ontology/imports/chebi_import.owl | 824 +- src/ontology/imports/chmo_import.owl | 35 +- src/ontology/imports/cob_import.owl | 104 +- src/ontology/imports/doid_import.owl | 2428 +- src/ontology/imports/efo_import.owl | 621 +- src/ontology/imports/envo_import.owl | 8338 +- src/ontology/imports/go_import.owl | 699 +- src/ontology/imports/go_top.tmp.owl | 155 +- src/ontology/imports/ncbitaxon_import.owl | 3445 +- src/ontology/imports/obi_import.owl | 147 +- src/ontology/imports/pato_import.owl | 1154 +- src/ontology/imports/pco_import.owl | 76 +- src/ontology/imports/ro_import.owl | 1065 +- src/ontology/imports/uberon_import.owl | 262651 +++---------------- src/ontology/imports/uo_import.owl | 1614 +- src/templates/RBO_classes.owl | 10 +- 21 files changed, 46261 insertions(+), 238793 deletions(-) diff --git a/rbo-base.owl b/rbo-base.owl index 3a23d31..a6ac4e8 100644 --- a/rbo-base.owl +++ b/rbo-base.owl @@ -12,12 +12,12 @@ xmlns:terms="http://purl.org/dc/terms/" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + RBO is an ontology for the effects of radiation on biota in terrestrial and space environments. Radiation Biology Ontology - 2023-12-07 + 2024-01-11 @@ -435,12 +435,6 @@ - - - - - - @@ -4018,7 +4012,7 @@ - + Nuclear decay in which an alpha particle is emitted. https://goldbook.iupac.org/terms/view/A00005 http://purl.obolibrary.org/obo/REX_0000017 @@ -4031,7 +4025,7 @@ - + Radioactive decay in which a beta particle is emitted or in which orbital electron capture occurs. http://goldbook.iupac.org/B00572.html http://purl.obolibrary.org/obo/REX_0000007 @@ -4453,7 +4447,7 @@ - + An atomic nucleus, fully stripped of its orbital electrons, containing 2 or more protons. Nuclei containing between 2 protons (helium) and 6 protons (carbon) are sometimes referred to as light ions. Jack Miller In RBO--needs def from NCRP Glossary (https://ncrponline.org/wp-content/themes/ncrp/PDFs/NCRP-Composite-Glossary.pdf) @@ -4613,6 +4607,12 @@ + + + + + + - - The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes). +1 H @@ -9267,7 +9265,7 @@ For example, A and B may be gene products and binding of B by A positively regul polynucleotides - ChEBI + ChEBI @@ -11407,7 +11405,7 @@ For example, A and B may be gene products and binding of B by A positively regul nucleobases - ChEBI + ChEBI @@ -12354,53 +12352,53 @@ For example, A and B may be gene products and binding of B by A positively regul - A monoatomic or polyatomic species having one or more elementary charges of the electron. - Anion - anion - chebi_ontology - Anionen - aniones - anions - CHEBI:22563 + A monoatomic or polyatomic species having one or more elementary charges of the electron. + Anion + anion + chebi_ontology + Anionen + aniones + anions + CHEBI:22563 - anion + anion - Anion - ChEBI + Anion + ChEBI - anion - ChEBI + anion + ChEBI - anion - IUPAC + anion + IUPAC - Anionen - ChEBI + Anionen + ChEBI - aniones - ChEBI + aniones + ChEBI - anions - IUPAC + anions + IUPAC @@ -12996,16 +12994,16 @@ For example, A and B may be gene products and binding of B by A positively regul Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. - molecular entity - chebi_ontology - entidad molecular - entidades moleculares - entite moleculaire - molecular entities - molekulare Entitaet - CHEBI:23367 + molecular entity + chebi_ontology + entidad molecular + entidades moleculares + entite moleculaire + molecular entities + molekulare Entitaet + CHEBI:23367 - molecular entity + molecular entity @@ -13016,39 +13014,39 @@ For example, A and B may be gene products and binding of B by A positively regul - molecular entity - IUPAC + molecular entity + IUPAC - entidad molecular - IUPAC + entidad molecular + IUPAC - entidades moleculares - IUPAC + entidades moleculares + IUPAC - entite moleculaire - IUPAC + entite moleculaire + IUPAC - molecular entities - IUPAC + molecular entities + IUPAC - molekulare Entitaet - ChEBI + molekulare Entitaet + ChEBI @@ -13058,18 +13056,8 @@ For example, A and B may be gene products and binding of B by A positively regul - chebi_ontology - monoatomic cations - CHEBI:23906 - - monoatomic cation + monoatomic cation - - - - monoatomic cations - ChEBI - @@ -13211,25 +13199,25 @@ For example, A and B may be gene products and binding of B by A positively regul - A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. + A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. A drug, solvent, chemical, etc., with a property that can be measured such as concentration. A molecular entity consisting of two or more chemical elements. James Malone Tomasz Adamusiak true chemical compound - chemical entity + chemical entity heteroatomic molecular entities heteroatomic molecular entity - chebi_ontology - CHEBI:24431 + chebi_ontology + CHEBI:24431 - chemical entity + chemical entity - chemical entity + chemical entity UniProt @@ -13424,13 +13412,13 @@ For example, A and B may be gene products and binding of B by A positively regul organic heterocycle - ChEBI + ChEBI organic heterocyclic compounds - ChEBI + ChEBI @@ -13616,17 +13604,17 @@ For example, A and B may be gene products and binding of B by A positively regul - chebi_ontology - inorganic anions - CHEBI:24834 + chebi_ontology + inorganic anions + CHEBI:24834 - inorganic anion + inorganic anion - inorganic anions - ChEBI + inorganic anions + ChEBI @@ -13635,46 +13623,46 @@ For example, A and B may be gene products and binding of B by A positively regul - A molecular entity that contains no carbon. - chebi_ontology - anorganische Verbindungen - inorganic compounds - inorganic entity - inorganic molecular entities - inorganics - CHEBI:24835 + A molecular entity that contains no carbon. + chebi_ontology + anorganische Verbindungen + inorganic compounds + inorganic entity + inorganic molecular entities + inorganics + CHEBI:24835 - inorganic molecular entity + inorganic molecular entity - anorganische Verbindungen - ChEBI + anorganische Verbindungen + ChEBI - inorganic compounds - ChEBI + inorganic compounds + ChEBI - inorganic entity - ChEBI + inorganic entity + ChEBI - inorganic molecular entities - ChEBI + inorganic molecular entities + ChEBI - inorganics - ChEBI + inorganics + ChEBI @@ -13807,18 +13795,8 @@ For example, A and B may be gene products and binding of B by A positively regul - chebi_ontology - monoatomic ions - CHEBI:24867 - - monoatomic ion + monoatomic ion - - - - monoatomic ions - ChEBI - @@ -13835,53 +13813,53 @@ For example, A and B may be gene products and binding of B by A positively regul - A molecular entity having a net electric charge. - Ion - ion - chebi_ontology - Ionen - iones - ions - CHEBI:24870 + A molecular entity having a net electric charge. + Ion + ion + chebi_ontology + Ionen + iones + ions + CHEBI:24870 - ion + ion - Ion - ChEBI + Ion + ChEBI - ion - ChEBI + ion + ChEBI - ion - IUPAC + ion + IUPAC - Ionen - ChEBI + Ionen + ChEBI - iones - ChEBI + iones + ChEBI - ions - ChEBI + ions + ChEBI @@ -14097,19 +14075,6 @@ For example, A and B may be gene products and binding of B by A positively regul mercury atom - - - - mercury - IUPAC - - - - - - 80Hg - IUPAC - @@ -14170,6 +14135,19 @@ For example, A and B may be gene products and binding of B by A positively regul CAS:7439-97-6 ChemIDplus + + + + mercury + IUPAC + + + + + + 80Hg + IUPAC + @@ -14289,28 +14267,8 @@ For example, A and B may be gene products and binding of B by A positively regul - +1 - 0.00000 - [*+] - chebi_ontology - monoatomic monocations - monovalent inorganic cations - CHEBI:25414 - - monoatomic monocation + monoatomic monocation - - - - monoatomic monocations - ChEBI - - - - - monovalent inorganic cations - ChEBI - @@ -18485,45 +18443,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - +2 - 0.00000 - [*++] - CHEBI:23856 - CHEBI:4665 - KEGG:C00572 - chebi_ontology - Divalent cation - divalent inorganic cations - monoatomic dications - CHEBI:30412 - - monoatomic dication - - - - - Divalent cation - KEGG_COMPOUND - - - - - divalent inorganic cations - ChEBI - - - - - monoatomic dications - ChEBI - - - - @@ -19660,26 +19579,26 @@ For example, A and B may be gene products and binding of B by A positively regul - A particle not known to have substructure. - elementary particle - chebi_ontology - elementary particles - CHEBI:33233 + A particle not known to have substructure. + elementary particle + chebi_ontology + elementary particles + CHEBI:33233 - fundamental particle + fundamental particle - elementary particle - IUPAC + elementary particle + IUPAC - elementary particles - ChEBI + elementary particles + ChEBI @@ -19688,26 +19607,8 @@ For example, A and B may be gene products and binding of B by A positively regul - A monoatomic entity is a molecular entity consisting of a single atom. - chebi_ontology - atomic entity - monoatomic entities - CHEBI:33238 - - monoatomic entity + monoatomic entity - - - - atomic entity - ChEBI - - - - - monoatomic entities - ChEBI - @@ -19925,7 +19826,6 @@ For example, A and B may be gene products and binding of B by A positively regul - 0 H @@ -20122,41 +20022,14 @@ For example, A and B may be gene products and binding of B by A positively regul - A molecular entity all atoms of which have the same atomic number. - chebi_ontology - homoatomic entity - homoatomic molecular entities - homoatomic molecular entity - CHEBI:33259 - - elemental molecular entity + elemental molecular entity - - - - homoatomic entity - ChEBI - - - - - homoatomic molecular entities - ChEBI - - - - - homoatomic molecular entity - ChEBI - - - chebi_ontology CHEBI:33260 @@ -21021,7 +20894,6 @@ For example, A and B may be gene products and binding of B by A positively regul - 0 He @@ -21045,7 +20917,6 @@ For example, A and B may be gene products and binding of B by A positively regul - +2 He @@ -26501,7 +26372,7 @@ For example, A and B may be gene products and binding of B by A positively regul cyclic compounds - ChEBI + ChEBI @@ -26565,27 +26436,27 @@ For example, A and B may be gene products and binding of B by A positively regul aromatic compounds - IUPAC + IUPAC aromatic molecular entity - IUPAC + IUPAC aromatics - ChEBI + ChEBI aromatische Verbindungen - ChEBI + ChEBI @@ -26605,7 +26476,7 @@ For example, A and B may be gene products and binding of B by A positively regul organic aromatic compounds - ChEBI + ChEBI @@ -26914,50 +26785,50 @@ For example, A and B may be gene products and binding of B by A positively regul nucleic acids - IUPAC + IUPAC NA - ChEBI + ChEBI Nukleinsaeure - ChEBI + ChEBI Nukleinsaeuren - ChEBI + ChEBI acide nucleique - ChEBI + ChEBI acides nucleiques - ChEBI + ChEBI acido nucleico - ChEBI + ChEBI acidos nucleicos - ChEBI + ChEBI @@ -27004,20 +26875,20 @@ For example, A and B may be gene products and binding of B by A positively regul ribonucleic acid - IUPAC + IUPAC ribonucleic acids - IUPAC + IUPAC RNA - IUPAC + IUPAC @@ -27029,13 +26900,13 @@ For example, A and B may be gene products and binding of B by A positively regul RNS - ChEBI + ChEBI Ribonukleinsaeure - ChEBI + ChEBI @@ -27047,19 +26918,19 @@ For example, A and B may be gene products and binding of B by A positively regul ribonucleic acids - ChEBI + ChEBI ribose nucleic acid - ChEBI + ChEBI yeast nucleic acid - ChEBI + ChEBI @@ -27380,7 +27251,7 @@ For example, A and B may be gene products and binding of B by A positively regul canonical nucleoside residues - ChEBI + ChEBI @@ -27398,7 +27269,7 @@ For example, A and B may be gene products and binding of B by A positively regul standard nucleoside residues - ChEBI + ChEBI @@ -27434,7 +27305,7 @@ For example, A and B may be gene products and binding of B by A positively regul canonical ribonucleoside residues - ChEBI + ChEBI @@ -27452,7 +27323,7 @@ For example, A and B may be gene products and binding of B by A positively regul standard ribonucleoside residues - ChEBI + ChEBI @@ -27683,7 +27554,7 @@ For example, A and B may be gene products and binding of B by A positively regul organic cyclic compounds - ChEBI + ChEBI @@ -27705,14 +27576,14 @@ For example, A and B may be gene products and binding of B by A positively regul heteroarenes - IUPAC + IUPAC hetarenes - IUPAC + IUPAC @@ -28208,18 +28079,18 @@ For example, A and B may be gene products and binding of B by A positively regul - Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin). - chebi_ontology - leptons - CHEBI:36338 + Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin). + chebi_ontology + leptons + CHEBI:36338 - lepton + lepton - leptons - ChEBI + leptons + ChEBI @@ -28229,18 +28100,18 @@ For example, A and B may be gene products and binding of B by A positively regul - Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy). - chebi_ontology - baryons - CHEBI:36339 + Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy). + chebi_ontology + baryons + CHEBI:36339 - baryon + baryon - baryons - ChEBI + baryons + ChEBI @@ -28249,26 +28120,26 @@ For example, A and B may be gene products and binding of B by A positively regul - Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi. - fermion - chebi_ontology - fermions - CHEBI:36340 + Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi. + fermion + chebi_ontology + fermions + CHEBI:36340 - fermion + fermion - fermion - IUPAC + fermion + IUPAC - fermions - ChEBI + fermions + ChEBI @@ -28277,26 +28148,26 @@ For example, A and B may be gene products and binding of B by A positively regul - Particle of integer spin quantum number following Bose-Einstein statistics. Bosons are named after Satyendra Nath Bose. - boson - chebi_ontology - bosons - CHEBI:36341 + Particle of integer spin quantum number following Bose-Einstein statistics. Bosons are named after Satyendra Nath Bose. + boson + chebi_ontology + bosons + CHEBI:36341 - boson + boson - boson - IUPAC + boson + IUPAC - bosons - ChEBI + bosons + ChEBI @@ -28305,20 +28176,20 @@ For example, A and B may be gene products and binding of B by A positively regul - A particle smaller than an atom. - Wikipedia:Subatomic_particle - chebi_ontology - subatomic particles - CHEBI:36342 + A particle smaller than an atom. + Wikipedia:Subatomic_particle + chebi_ontology + subatomic particles + CHEBI:36342 + subatomic particle subatomic particle - subatomic particle - subatomic particles - ChEBI + subatomic particles + ChEBI @@ -28327,18 +28198,18 @@ For example, A and B may be gene products and binding of B by A positively regul - A subatomic particle known to have substructure (i.e. consisting of smaller particles). - chebi_ontology - composite particles - CHEBI:36343 + A subatomic particle known to have substructure (i.e. consisting of smaller particles). + chebi_ontology + composite particles + CHEBI:36343 - composite particle + composite particle - composite particles - ChEBI + composite particles + ChEBI @@ -28347,39 +28218,18 @@ For example, A and B may be gene products and binding of B by A positively regul - Hadron is a subatomic particle which experiences the strong force. - chebi_ontology - hadrons - CHEBI:36344 + Hadron is a subatomic particle which experiences the strong force. + chebi_ontology + hadrons + CHEBI:36344 - hadron + hadron - hadrons - ChEBI - - - - - - - - - - A hadron with zero or integer spin; a strongly interacting boson. The term is derived from the Greek muepsilonsigmaomicronsigma (medium, middle). - chebi_ontology - mesons - CHEBI:36345 - - meson - - - - - mesons - ChEBI + hadrons + ChEBI @@ -28408,7 +28258,6 @@ For example, A and B may be gene products and binding of B by A positively regul - The collective name for zero-spin mesons pi(+), pi(-) and pi(0). pi meson pion @@ -28443,7 +28292,6 @@ For example, A and B may be gene products and binding of B by A positively regul - Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.113428913(17) u, or 105.658389(34) MeV. -1 0.113428913 @@ -28640,17 +28488,17 @@ For example, A and B may be gene products and binding of B by A positively regul - chebi_ontology - inorganic ions - CHEBI:36914 + chebi_ontology + inorganic ions + CHEBI:36914 - inorganic ion + inorganic ion - inorganic ions - ChEBI + inorganic ions + ChEBI @@ -28660,17 +28508,17 @@ For example, A and B may be gene products and binding of B by A positively regul - chebi_ontology - inorganic cations - CHEBI:36915 + chebi_ontology + inorganic cations + CHEBI:36915 - inorganic cation + inorganic cation - inorganic cations - ChEBI + inorganic cations + ChEBI @@ -28679,63 +28527,63 @@ For example, A and B may be gene products and binding of B by A positively regul - A monoatomic or polyatomic species having one or more elementary charges of the proton. - CHEBI:23058 - CHEBI:3473 - KEGG:C01373 - Cation - cation - chebi_ontology - Kation - Kationen - cationes - cations - CHEBI:36916 + A monoatomic or polyatomic species having one or more elementary charges of the proton. + CHEBI:23058 + CHEBI:3473 + KEGG:C01373 + Cation + cation + chebi_ontology + Kation + Kationen + cationes + cations + CHEBI:36916 - cation + cation - Cation + Cation KEGG_COMPOUND - cation - ChEBI + cation + ChEBI - cation - IUPAC + cation + IUPAC - Kation - ChEBI + Kation + ChEBI - Kationen - ChEBI + Kationen + ChEBI - cationes - ChEBI + cationes + ChEBI - cations - ChEBI + cations + ChEBI @@ -33048,13 +32896,13 @@ For example, A and B may be gene products and binding of B by A positively regul heterocyclic organonitrogen compounds - ChEBI + ChEBI organonitrogen heterocyclic compounds - ChEBI + ChEBI @@ -34209,7 +34057,7 @@ For example, A and B may be gene products and binding of B by A positively regul canonical nucleotide residues - ChEBI + ChEBI @@ -34228,7 +34076,7 @@ For example, A and B may be gene products and binding of B by A positively regul canonical ribonucleotide residues - ChEBI + ChEBI @@ -34301,7 +34149,7 @@ For example, A and B may be gene products and binding of B by A positively regul nucleotide residues - ChEBI + ChEBI @@ -34320,7 +34168,7 @@ For example, A and B may be gene products and binding of B by A positively regul nucleoside residues - ChEBI + ChEBI @@ -36284,25 +36132,25 @@ For example, A and B may be gene products and binding of B by A positively regul compuesto heterociclico - IUPAC + IUPAC compuestos heterociclicos - IUPAC + IUPAC heterocycle - ChEBI + ChEBI heterocyclic compounds - ChEBI + ChEBI @@ -36355,17 +36203,17 @@ For example, A and B may be gene products and binding of B by A positively regul - An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one. - chebi_ontology - a monovalent cation - CHEBI:60242 + An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one. + chebi_ontology + a monovalent cation + CHEBI:60242 - monovalent inorganic cation + monovalent inorganic cation - a monovalent cation + a monovalent cation UniProt @@ -36436,13 +36284,13 @@ For example, A and B may be gene products and binding of B by A positively regul nucleobase-containing compounds - ChEBI + ChEBI nucleobase-containing molecular entities - ChEBI + ChEBI @@ -37441,18 +37289,18 @@ For example, A and B may be gene products and binding of B by A positively regul - Any inorganic anion with a valency of two. - chebi_ontology - divalent inorganic anions - CHEBI:79388 + Any inorganic anion with a valency of two. + chebi_ontology + divalent inorganic anions + CHEBI:79388 - divalent inorganic anion + divalent inorganic anion - divalent inorganic anions - ChEBI + divalent inorganic anions + ChEBI @@ -37461,18 +37309,18 @@ For example, A and B may be gene products and binding of B by A positively regul - Any inorganic anion with a valency of one. - chebi_ontology - monovalent inorganic anions - CHEBI:79389 + Any inorganic anion with a valency of one. + chebi_ontology + monovalent inorganic anions + CHEBI:79389 - monovalent inorganic anion + monovalent inorganic anion - monovalent inorganic anions - ChEBI + monovalent inorganic anions + ChEBI @@ -69250,7 +69098,7 @@ Note that, in addition to forming the root of the cellular component ontology, t The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. - ISBN:0471245208 + ISBN:0471245208 @@ -88537,7 +88385,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that modulates the frequency, rate or extent of blood circulation. GOC:TermGenie GOC:mr - GO_REF:0000058 + GO_REF:0000058 PMID:10659969 @@ -88593,7 +88441,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. GOC:TermGenie GOC:mr - GO_REF:0000058 + GO_REF:0000058 PMID:10659969 @@ -88697,7 +88545,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of blood circulation. GOC:TermGenie GOC:mr - GO_REF:0000058 + GO_REF:0000058 PMID:10659969 @@ -88793,7 +88641,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that modulates the frequency, rate or extent of secretion by cell. GOC:TermGenie GOC:pm - GO_REF:0000058 + GO_REF:0000058 PMID:12130530 @@ -88850,7 +88698,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell. GOC:TermGenie GOC:pm - GO_REF:0000058 + GO_REF:0000058 PMID:12130530 @@ -88955,7 +88803,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of secretion by cell. GOC:TermGenie GOC:pm - GO_REF:0000058 + GO_REF:0000058 PMID:12130530 @@ -89098,7 +88946,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:PARL GOC:TermGenie GOC:pad - GO_REF:0000058 + GO_REF:0000058 PMID:20080761 @@ -89191,7 +89039,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:PARL GOC:TermGenie GOC:pad - GO_REF:0000058 + GO_REF:0000058 PMID:20080761 @@ -89404,7 +89252,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:PARL GOC:TermGenie GOC:pad - GO_REF:0000058 + GO_REF:0000058 PMID:20080761 @@ -89592,7 +89440,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of anion transport. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:11336802 @@ -89660,7 +89508,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of anion transport. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:11336802 @@ -89736,7 +89584,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization. GOC:TermGenie GOC:vw - GO_REF:0000058 + GO_REF:0000058 @@ -89839,7 +89687,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of a protein localization. GOC:TermGenie GOC:vw - GO_REF:0000058 + GO_REF:0000058 @@ -89924,7 +89772,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:22819705 @@ -89992,7 +89840,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:22819705 @@ -90066,7 +89914,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of vasculature development. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:21472453 @@ -90174,7 +90022,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:17167094 @@ -90312,7 +90160,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of sensory perception of pain. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:17167094 @@ -90439,7 +90287,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that modulates the frequency, rate or extent of bile acid metabolic process. GOC:TermGenie GOC:bf - GO_REF:0000058 + GO_REF:0000058 @@ -90496,7 +90344,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process. GOC:TermGenie GOC:bf - GO_REF:0000058 + GO_REF:0000058 @@ -90601,7 +90449,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of bile acid metabolic process. GOC:TermGenie GOC:bf - GO_REF:0000058 + GO_REF:0000058 @@ -90713,7 +90561,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:22761445 @@ -90886,7 +90734,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of establishment of protein localization. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:22761445 @@ -91042,7 +90890,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that modulates the frequency, rate or extent of epithelial tube formation. GOC:TermGenie GOC:bhm - GO_REF:0000058 + GO_REF:0000058 PMID:25745997 @@ -91089,7 +90937,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation. GOC:TermGenie GOC:bhm - GO_REF:0000058 + GO_REF:0000058 PMID:25745997 @@ -91160,7 +91008,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of epithelial tube formation. GOC:TermGenie GOC:bhm - GO_REF:0000058 + GO_REF:0000058 PMID:25745997 @@ -91226,7 +91074,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. GOC:TermGenie GOC:bhm - GO_REF:0000058 + GO_REF:0000058 PMID:25745997 @@ -91283,7 +91131,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. GOC:TermGenie GOC:bhm - GO_REF:0000058 + GO_REF:0000058 PMID:25745997 @@ -91388,7 +91236,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. GOC:TermGenie GOC:bhm - GO_REF:0000058 + GO_REF:0000058 PMID:25745997 @@ -91487,7 +91335,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:BHF_telomere GOC:TermGenie GOC:nc - GO_REF:0000058 + GO_REF:0000058 PMID:23201774 @@ -91546,7 +91394,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:BHF_telomere GOC:TermGenie GOC:nc - GO_REF:0000058 + GO_REF:0000058 PMID:23201774 @@ -91653,7 +91501,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:BHF_telomere GOC:TermGenie GOC:nc - GO_REF:0000058 + GO_REF:0000058 PMID:23201774 @@ -91859,14 +91707,6 @@ Note that this term is in the subset of terms that should not be used for direct GO:1905844 negative regulation of cellular response to gamma radiation - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to gamma radiation. - GOC:TermGenie - GO_REF:0000058 - PMID:23505386 - @@ -91951,6 +91791,14 @@ Note that this term is in the subset of terms that should not be used for direct negative regulation of cellular response to gamma-ray photon GOC:TermGenie + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to gamma radiation. + GOC:TermGenie + GO_REF:0000058 + PMID:23505386 + @@ -92129,7 +91977,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:BHF_miRNA GOC:TermGenie GOC:rph - GO_REF:0000058 + GO_REF:0000058 PMID:23939491 @@ -92176,7 +92024,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:BHF_miRNA GOC:TermGenie GOC:rph - GO_REF:0000058 + GO_REF:0000058 PMID:23939491 @@ -92247,7 +92095,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:BHF_miRNA GOC:TermGenie GOC:rph - GO_REF:0000058 + GO_REF:0000058 PMID:23939491 @@ -92311,7 +92159,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that modulates the frequency, rate or extent of lipid localization. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:17564681 @@ -92366,7 +92214,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:17564681 @@ -92469,7 +92317,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of lipid localization. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:17564681 @@ -112211,7 +112059,7 @@ Classes for population already exist in IDO ('organism population', I - + Nuclear decay in which an alpha particle is emitted. https://goldbook.iupac.org/terms/view/A00005 http://purl.obolibrary.org/obo/REX_0000017 @@ -112224,7 +112072,7 @@ Classes for population already exist in IDO ('organism population', I - + Radioactive decay in which a beta particle is emitted or in which orbital electron capture occurs. http://goldbook.iupac.org/B00572.html http://purl.obolibrary.org/obo/REX_0000007 @@ -112658,7 +112506,7 @@ Classes for population already exist in IDO ('organism population', I - + An atomic nucleus, fully stripped of its orbital electrons, containing 2 or more protons. Nuclei containing between 2 protons (helium) and 6 protons (carbon) are sometimes referred to as light ions. Jack Miller In RBO--needs def from NCRP Glossary (https://ncrponline.org/wp-content/themes/ncrp/PDFs/NCRP-Composite-Glossary.pdf) @@ -149213,7 +149061,7 @@ Classes for population already exist in IDO ('organism population', I - ZFA + ZFA pending @@ -150376,7 +150224,7 @@ Classes for population already exist in IDO ('organism population', I - ZFA + ZFA https://github.com/obophenotype/uberon/issues/378 ABA pending @@ -150385,7 +150233,7 @@ Classes for population already exist in IDO ('organism population', I - ZFA + ZFA ABA pending @@ -158012,7 +157860,7 @@ Classes for population already exist in IDO ('organism population', I - ZFA + ZFA pending @@ -270148,6 +269996,12 @@ Classes for population already exist in IDO ('organism population', I + + + + + + @@ -275296,8 +275150,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim m A length unit which is equal to the length of the path traveled by light in vacuum during a time interval of 1/299 792 458 of a second. - meter m + meter metre "A length unit which is equal to the length of the path traveled by light in vacuum during a time interval of 1/299 792 458 of a second." [BIPM:BIPM, NIST:NIST] @@ -275311,8 +275165,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim A mass unit which is equal to the mass of the International Prototype Kilogram kept by the BIPM at Svres, France. - s + s s second sec @@ -275324,8 +275178,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim cm centimeter centimetre - cm centimeter + cm "A length unit which is equal to one hundredth of a meter or 10^[-2] m." [NIST:NIST] A length unit which is equal to one hundredth of a meter or 10^[-2] m. @@ -275334,8 +275188,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim A length unit which is equal to one thousandth of a meter or 10^[-3] m. mm micrometre - millimeter + mm millimeter "A length unit which is equal to one thousandth of a meter or 10^[-3] m." [NIST:NIST] @@ -275358,13 +275212,13 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim A length unit which is equal to one thousandth of one millionth of a meter or 10^[-9] m. nanometre nanometer - "A length unit which is equal to one thousandth of one millionth of a meter or 10^[-9] m." [NIST:NIST] + "A length unit which is equal to one thousandth of one millionth of a meter or 10^[-9] m." [NIST:NIST] Å - angstrom angstrom + angstrom "A length unit which is equal to 10 [-10] m." [NIST:NIST] A length unit which is equal to 10 [-10] m. @@ -275434,8 +275288,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim "A time unit which is equal to 60 seconds." [Wikipedia:Wikipedia] - hour + hour hour h h @@ -275444,8 +275298,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim "A time unit which is equal to 3600 seconds or 60 minutes." [Wikipedia:Wikipedia] - day + "A time unit which is equal to 24 hours." [Wikipedia:Wikipedia] A time unit which is equal to 24 hours. day @@ -275454,8 +275308,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim week "A time unit which is equal to 7 days." [Wikipedia:Wikipedia] - week A time unit which is equal to 7 days. + week @@ -275466,8 +275320,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim year - A time unit which is equal to 12 months which is science is taken to be equal to 365.25 days. "A time unit which is equal to 12 months which in science is taken to be equal to 365.25 days." [Wikipedia:Wikipedia] + A time unit which is equal to 12 months which is science is taken to be equal to 365.25 days. year @@ -275495,32 +275349,32 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim pmol A substance unit equal to 10^[-12] mol. - picomole picomole + picomole M "A unit of concentration which expresses a concentration of 1 mole of solute per liter of solution (mol/L)." [UOC:GVG] A unit of concentration which expresses a concentration of 1 mole of solute per liter of solution (mol/L). M - molar + molar A unit of molarity which is equal to one thousandth of a molar or 10^[-3] M. - mM millimolar + mM - mM millimolar + mM "A unit of molarity which is equal to one thousandth of a molar or 10^[-3] M." [UOC:GVG] uM micromolar - A unit of molarity which is equal to one millionth of a molar or 10^[-6] M. uM + A unit of molarity which is equal to one millionth of a molar or 10^[-6] M. micromolar "A unit of molarity which is equal to one millionth of a molar or 10^[-6] M." [UOC:GVG] @@ -275539,14 +275393,14 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim picomolar "A unit of molarity which is equal to 10^[-12] M." [UOC:GVG] picomolar + A unit of molarity which is equal to 10^[-12] M. pM - cubic centimeter - A volume unit which is equal to one millionth of a cubic meter or 10^[-9] m^[3], or to 1 ml. + cubic centimetre cubic centimeter cm^3 @@ -275561,8 +275415,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim millilitre A volume unit which is equal to one thousandth of a liter or 10^[-3] L, or to 1 cubic centimeter. - ml milliliter + ml litre @@ -275585,11 +275439,11 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim - microliter microliter + microliter ul - microlitre A volume unit which is equal to one millionth of a liter or 10^[-6] L. + microlitre ul "A volume unit which is equal to one millionth of a liter or 10^[-6] L." [NIST:NIST] @@ -275598,8 +275452,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim nl A volume unit which is equal to one thousandth of one millionth of a liter or 10^[-9] L. nanoliter - "A volume unit which is equal to one thousandth of one millionth of a liter or 10^[-9] L." [NIST:NIST] + "A volume unit which is equal to one thousandth of one millionth of a liter or 10^[-9] L." [NIST:NIST] nanoliter nanolitre nl @@ -275618,8 +275472,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim hertz Hz - A frequency unit which is equal to 1 complete cycle of a recurring phenomenon in 1 second. "A frequency unit which is equal to 1 complete cycle of a recurring phenomenon in 1 second." [NIST:NIST] + A frequency unit which is equal to 1 complete cycle of a recurring phenomenon in 1 second. hertz s^1 @@ -275635,22 +275489,22 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim A dimensionless concentration unit which denotes the mass of a substance in a mixture as a percentage of the mass of the entire mixture. - - mass volume percentage % w/v + mass volume percentage + A dimensionless concentration unit which denotes the mass of the substance in a mixture as a percentage of the volume of the entire mixture. mass volume percentage weight-volume percentage percent vol per vol - "A dimensionless concentration unit which denotes the mass of the substance in a mixture as a percentage of the volume of the entire mixture." [UOC:GVG] (w/v) + "A dimensionless concentration unit which denotes the mass of the substance in a mixture as a percentage of the volume of the entire mixture." [UOC:GVG] % v/v volume percentage - % (v/v) "A dimensionless concentration unit which denotes the volume of the solute in mL per 100 mL of the resulting solution." [UOC:GVG] + % (v/v) A dimensionless concentration unit which denotes the volume of the solute in mL per 100 mL of the resulting solution. percent vol per vol volume percentage @@ -275671,8 +275525,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim "A mass unit density which is equal to mass of an object in milligrams divided by the volume in milliliters." [UOC:GVG] milligram per milliliter mg per ml - milligram per milliliter A mass unit density which is equal to mass of an object in milligrams divided by the volume in milliliters. + milligram per milliliter milligram per millilitre mg/ml @@ -275704,8 +275558,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim milliliter per liter - "A mass density unit which is equal to mass of an object in grams divided by the volume in deciliters." [UOC:GVG] gram per deciliter + "A mass density unit which is equal to mass of an object in grams divided by the volume in deciliters." [UOC:GVG] g/dl gram per decilitre A mass density unit which is equal to mass of an object in grams divided by the volume in deciliters. @@ -275714,8 +275568,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim g/dl - colony forming unit per volume + colony forming unit per volume "A concentration unit which a measure of viable bacterial numbers in a given volume." [Wikipedia:Wikipedia] A concentration unit which a measure of viable bacterial numbers in a given volume. @@ -275750,8 +275604,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim "A rate unit which is equal to one over one nanomolar." [UO:GVG] 1/nM - count per nanomolar count per nanomolar + count per nanomolar nM^-1 @@ -275769,8 +275623,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim ug/L microgram per litre - ng/ml microgram per liter + ng/ml ug/L microgram per liter diff --git a/rbo.owl b/rbo.owl index 5ec6e93..d1bdb82 100644 --- a/rbo.owl +++ b/rbo.owl @@ -32,11 +32,11 @@ xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#" xmlns:oboInOwl1="oboInOwl:"> - + RBO is an ontology for the effects of radiation on biota in terrestrial and space environments. Radiation Biology Ontology - 2023-12-07 + 2024-01-11 @@ -8984,10 +8984,8 @@ For example, A and B may be gene products and binding of B by A positively regul - - The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes). +1 H @@ -12350,52 +12348,52 @@ For example, A and B may be gene products and binding of B by A positively regul - A monoatomic or polyatomic species having one or more elementary charges of the electron. - Anion - anion - chebi_ontology - Anionen - aniones - anions - CHEBI:22563 + A monoatomic or polyatomic species having one or more elementary charges of the electron. + Anion + anion + chebi_ontology + Anionen + aniones + anions + CHEBI:22563 - anion + anion - Anion + Anion ChEBI - anion + anion ChEBI - anion + anion IUPAC - Anionen + Anionen ChEBI - aniones + aniones ChEBI - anions + anions IUPAC @@ -12992,16 +12990,16 @@ For example, A and B may be gene products and binding of B by A positively regul Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. - molecular entity - chebi_ontology - entidad molecular - entidades moleculares - entite moleculaire - molecular entities - molekulare Entitaet - CHEBI:23367 + molecular entity + chebi_ontology + entidad molecular + entidades moleculares + entite moleculaire + molecular entities + molekulare Entitaet + CHEBI:23367 - molecular entity + molecular entity @@ -13012,38 +13010,38 @@ For example, A and B may be gene products and binding of B by A positively regul - molecular entity + molecular entity IUPAC - entidad molecular + entidad molecular IUPAC - entidades moleculares + entidades moleculares IUPAC - entite moleculaire + entite moleculaire IUPAC - molecular entities + molecular entities IUPAC - molekulare Entitaet + molekulare Entitaet ChEBI @@ -13054,18 +13052,8 @@ For example, A and B may be gene products and binding of B by A positively regul - chebi_ontology - monoatomic cations - CHEBI:23906 - - monoatomic cation + monoatomic cation - - - - monoatomic cations - ChEBI - @@ -13207,25 +13195,25 @@ For example, A and B may be gene products and binding of B by A positively regul - A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. + A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. A drug, solvent, chemical, etc., with a property that can be measured such as concentration. A molecular entity consisting of two or more chemical elements. James Malone Tomasz Adamusiak true chemical compound - chemical entity + chemical entity heteroatomic molecular entities heteroatomic molecular entity - chebi_ontology - CHEBI:24431 + chebi_ontology + CHEBI:24431 - chemical entity + chemical entity - chemical entity + chemical entity UniProt @@ -13612,16 +13600,16 @@ For example, A and B may be gene products and binding of B by A positively regul - chebi_ontology - inorganic anions - CHEBI:24834 + chebi_ontology + inorganic anions + CHEBI:24834 - inorganic anion + inorganic anion - inorganic anions + inorganic anions ChEBI @@ -13631,45 +13619,45 @@ For example, A and B may be gene products and binding of B by A positively regul - A molecular entity that contains no carbon. - chebi_ontology - anorganische Verbindungen - inorganic compounds - inorganic entity - inorganic molecular entities - inorganics - CHEBI:24835 + A molecular entity that contains no carbon. + chebi_ontology + anorganische Verbindungen + inorganic compounds + inorganic entity + inorganic molecular entities + inorganics + CHEBI:24835 - inorganic molecular entity + inorganic molecular entity - anorganische Verbindungen + anorganische Verbindungen ChEBI - inorganic compounds + inorganic compounds ChEBI - inorganic entity + inorganic entity ChEBI - inorganic molecular entities + inorganic molecular entities ChEBI - inorganics + inorganics ChEBI @@ -13803,18 +13791,8 @@ For example, A and B may be gene products and binding of B by A positively regul - chebi_ontology - monoatomic ions - CHEBI:24867 - - monoatomic ion + monoatomic ion - - - - monoatomic ions - ChEBI - @@ -13831,52 +13809,52 @@ For example, A and B may be gene products and binding of B by A positively regul - A molecular entity having a net electric charge. - Ion - ion - chebi_ontology - Ionen - iones - ions - CHEBI:24870 + A molecular entity having a net electric charge. + Ion + ion + chebi_ontology + Ionen + iones + ions + CHEBI:24870 - ion + ion - Ion + Ion ChEBI - ion + ion ChEBI - ion + ion IUPAC - Ionen + Ionen ChEBI - iones + iones ChEBI - ions + ions ChEBI @@ -14006,18 +13984,6 @@ For example, A and B may be gene products and binding of B by A positively regul magnesium atom - - - - magnesio - ChEBI - - - - - magnesium - ChEBI - @@ -14061,6 +14027,18 @@ For example, A and B may be gene products and binding of B by A positively regul Mg UniProt + + + + magnesio + ChEBI + + + + + magnesium + ChEBI + @@ -14285,28 +14263,8 @@ For example, A and B may be gene products and binding of B by A positively regul - +1 - 0.00000 - [*+] - chebi_ontology - monoatomic monocations - monovalent inorganic cations - CHEBI:25414 - - monoatomic monocation + monoatomic monocation - - - - monoatomic monocations - ChEBI - - - - - monovalent inorganic cations - ChEBI - @@ -18481,45 +18439,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - +2 - 0.00000 - [*++] - CHEBI:23856 - CHEBI:4665 - KEGG:C00572 - chebi_ontology - Divalent cation - divalent inorganic cations - monoatomic dications - CHEBI:30412 - - monoatomic dication - - - - - Divalent cation - KEGG_COMPOUND - - - - - divalent inorganic cations - ChEBI - - - - - monoatomic dications - ChEBI - - - - @@ -19656,25 +19575,25 @@ For example, A and B may be gene products and binding of B by A positively regul - A particle not known to have substructure. - elementary particle - chebi_ontology - elementary particles - CHEBI:33233 + A particle not known to have substructure. + elementary particle + chebi_ontology + elementary particles + CHEBI:33233 - fundamental particle + fundamental particle - elementary particle + elementary particle IUPAC - elementary particles + elementary particles ChEBI @@ -19684,26 +19603,8 @@ For example, A and B may be gene products and binding of B by A positively regul - A monoatomic entity is a molecular entity consisting of a single atom. - chebi_ontology - atomic entity - monoatomic entities - CHEBI:33238 - - monoatomic entity + monoatomic entity - - - - atomic entity - ChEBI - - - - - monoatomic entities - ChEBI - @@ -19921,7 +19822,6 @@ For example, A and B may be gene products and binding of B by A positively regul - 0 H @@ -20118,41 +20018,14 @@ For example, A and B may be gene products and binding of B by A positively regul - A molecular entity all atoms of which have the same atomic number. - chebi_ontology - homoatomic entity - homoatomic molecular entities - homoatomic molecular entity - CHEBI:33259 - - elemental molecular entity + elemental molecular entity - - - - homoatomic entity - ChEBI - - - - - homoatomic molecular entities - ChEBI - - - - - homoatomic molecular entity - ChEBI - - - chebi_ontology CHEBI:33260 @@ -21017,7 +20890,6 @@ For example, A and B may be gene products and binding of B by A positively regul - 0 He @@ -21041,7 +20913,6 @@ For example, A and B may be gene products and binding of B by A positively regul - +2 He @@ -28204,17 +28075,17 @@ For example, A and B may be gene products and binding of B by A positively regul - Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin). - chebi_ontology - leptons - CHEBI:36338 + Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin). + chebi_ontology + leptons + CHEBI:36338 - lepton + lepton - leptons + leptons ChEBI @@ -28225,17 +28096,17 @@ For example, A and B may be gene products and binding of B by A positively regul - Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy). - chebi_ontology - baryons - CHEBI:36339 + Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy). + chebi_ontology + baryons + CHEBI:36339 - baryon + baryon - baryons + baryons ChEBI @@ -28245,25 +28116,25 @@ For example, A and B may be gene products and binding of B by A positively regul - Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi. - fermion - chebi_ontology - fermions - CHEBI:36340 + Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi. + fermion + chebi_ontology + fermions + CHEBI:36340 - fermion + fermion - fermion + fermion IUPAC - fermions + fermions ChEBI @@ -28273,25 +28144,25 @@ For example, A and B may be gene products and binding of B by A positively regul - Particle of integer spin quantum number following Bose-Einstein statistics. Bosons are named after Satyendra Nath Bose. - boson - chebi_ontology - bosons - CHEBI:36341 + Particle of integer spin quantum number following Bose-Einstein statistics. Bosons are named after Satyendra Nath Bose. + boson + chebi_ontology + bosons + CHEBI:36341 - boson + boson - boson + boson IUPAC - bosons + bosons ChEBI @@ -28301,19 +28172,19 @@ For example, A and B may be gene products and binding of B by A positively regul - A particle smaller than an atom. - Wikipedia:Subatomic_particle - chebi_ontology - subatomic particles - CHEBI:36342 + A particle smaller than an atom. + Wikipedia:Subatomic_particle + chebi_ontology + subatomic particles + CHEBI:36342 + subatomic particle subatomic particle - subatomic particle - subatomic particles + subatomic particles ChEBI @@ -28323,17 +28194,17 @@ For example, A and B may be gene products and binding of B by A positively regul - A subatomic particle known to have substructure (i.e. consisting of smaller particles). - chebi_ontology - composite particles - CHEBI:36343 + A subatomic particle known to have substructure (i.e. consisting of smaller particles). + chebi_ontology + composite particles + CHEBI:36343 - composite particle + composite particle - composite particles + composite particles ChEBI @@ -28343,38 +28214,17 @@ For example, A and B may be gene products and binding of B by A positively regul - Hadron is a subatomic particle which experiences the strong force. - chebi_ontology - hadrons - CHEBI:36344 + Hadron is a subatomic particle which experiences the strong force. + chebi_ontology + hadrons + CHEBI:36344 - hadron + hadron - hadrons - ChEBI - - - - - - - - - - A hadron with zero or integer spin; a strongly interacting boson. The term is derived from the Greek muepsilonsigmaomicronsigma (medium, middle). - chebi_ontology - mesons - CHEBI:36345 - - meson - - - - - mesons + hadrons ChEBI @@ -28404,7 +28254,6 @@ For example, A and B may be gene products and binding of B by A positively regul - The collective name for zero-spin mesons pi(+), pi(-) and pi(0). pi meson pion @@ -28439,7 +28288,6 @@ For example, A and B may be gene products and binding of B by A positively regul - Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.113428913(17) u, or 105.658389(34) MeV. -1 0.113428913 @@ -28636,16 +28484,16 @@ For example, A and B may be gene products and binding of B by A positively regul - chebi_ontology - inorganic ions - CHEBI:36914 + chebi_ontology + inorganic ions + CHEBI:36914 - inorganic ion + inorganic ion - inorganic ions + inorganic ions ChEBI @@ -28656,16 +28504,16 @@ For example, A and B may be gene products and binding of B by A positively regul - chebi_ontology - inorganic cations - CHEBI:36915 + chebi_ontology + inorganic cations + CHEBI:36915 - inorganic cation + inorganic cation - inorganic cations + inorganic cations ChEBI @@ -28675,62 +28523,62 @@ For example, A and B may be gene products and binding of B by A positively regul - A monoatomic or polyatomic species having one or more elementary charges of the proton. - CHEBI:23058 - CHEBI:3473 - KEGG:C01373 - Cation - cation - chebi_ontology - Kation - Kationen - cationes - cations - CHEBI:36916 + A monoatomic or polyatomic species having one or more elementary charges of the proton. + CHEBI:23058 + CHEBI:3473 + KEGG:C01373 + Cation + cation + chebi_ontology + Kation + Kationen + cationes + cations + CHEBI:36916 - cation + cation - Cation + Cation KEGG_COMPOUND - cation + cation ChEBI - cation + cation IUPAC - Kation + Kation ChEBI - Kationen + Kationen ChEBI - cationes + cationes ChEBI - cations + cations ChEBI @@ -36351,17 +36199,17 @@ For example, A and B may be gene products and binding of B by A positively regul - An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one. - chebi_ontology - a monovalent cation - CHEBI:60242 + An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one. + chebi_ontology + a monovalent cation + CHEBI:60242 - monovalent inorganic cation + monovalent inorganic cation - a monovalent cation + a monovalent cation UniProt @@ -37437,17 +37285,17 @@ For example, A and B may be gene products and binding of B by A positively regul - Any inorganic anion with a valency of two. - chebi_ontology - divalent inorganic anions - CHEBI:79388 + Any inorganic anion with a valency of two. + chebi_ontology + divalent inorganic anions + CHEBI:79388 - divalent inorganic anion + divalent inorganic anion - divalent inorganic anions + divalent inorganic anions ChEBI @@ -37457,17 +37305,17 @@ For example, A and B may be gene products and binding of B by A positively regul - Any inorganic anion with a valency of one. - chebi_ontology - monovalent inorganic anions - CHEBI:79389 + Any inorganic anion with a valency of one. + chebi_ontology + monovalent inorganic anions + CHEBI:79389 - monovalent inorganic anion + monovalent inorganic anion - monovalent inorganic anions + monovalent inorganic anions ChEBI @@ -69246,7 +69094,7 @@ Note that, in addition to forming the root of the cellular component ontology, t The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. - ISBN:0471245208 + ISBN:0471245208 @@ -88533,7 +88381,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that modulates the frequency, rate or extent of blood circulation. GOC:TermGenie GOC:mr - GO_REF:0000058 + GO_REF:0000058 PMID:10659969 @@ -88589,7 +88437,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. GOC:TermGenie GOC:mr - GO_REF:0000058 + GO_REF:0000058 PMID:10659969 @@ -88693,7 +88541,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of blood circulation. GOC:TermGenie GOC:mr - GO_REF:0000058 + GO_REF:0000058 PMID:10659969 @@ -88789,7 +88637,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that modulates the frequency, rate or extent of secretion by cell. GOC:TermGenie GOC:pm - GO_REF:0000058 + GO_REF:0000058 PMID:12130530 @@ -88846,7 +88694,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell. GOC:TermGenie GOC:pm - GO_REF:0000058 + GO_REF:0000058 PMID:12130530 @@ -88951,7 +88799,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of secretion by cell. GOC:TermGenie GOC:pm - GO_REF:0000058 + GO_REF:0000058 PMID:12130530 @@ -89094,7 +88942,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:PARL GOC:TermGenie GOC:pad - GO_REF:0000058 + GO_REF:0000058 PMID:20080761 @@ -89187,7 +89035,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:PARL GOC:TermGenie GOC:pad - GO_REF:0000058 + GO_REF:0000058 PMID:20080761 @@ -89400,7 +89248,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:PARL GOC:TermGenie GOC:pad - GO_REF:0000058 + GO_REF:0000058 PMID:20080761 @@ -89588,7 +89436,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of anion transport. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:11336802 @@ -89656,7 +89504,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of anion transport. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:11336802 @@ -89732,7 +89580,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization. GOC:TermGenie GOC:vw - GO_REF:0000058 + GO_REF:0000058 @@ -89835,7 +89683,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of a protein localization. GOC:TermGenie GOC:vw - GO_REF:0000058 + GO_REF:0000058 @@ -89920,7 +89768,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:22819705 @@ -89988,7 +89836,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:22819705 @@ -90062,7 +89910,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of vasculature development. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:21472453 @@ -90170,7 +90018,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:17167094 @@ -90308,7 +90156,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of sensory perception of pain. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:17167094 @@ -90435,7 +90283,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that modulates the frequency, rate or extent of bile acid metabolic process. GOC:TermGenie GOC:bf - GO_REF:0000058 + GO_REF:0000058 @@ -90492,7 +90340,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process. GOC:TermGenie GOC:bf - GO_REF:0000058 + GO_REF:0000058 @@ -90597,7 +90445,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of bile acid metabolic process. GOC:TermGenie GOC:bf - GO_REF:0000058 + GO_REF:0000058 @@ -90709,7 +90557,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:22761445 @@ -90882,7 +90730,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of establishment of protein localization. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:22761445 @@ -91038,7 +90886,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that modulates the frequency, rate or extent of epithelial tube formation. GOC:TermGenie GOC:bhm - GO_REF:0000058 + GO_REF:0000058 PMID:25745997 @@ -91085,7 +90933,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation. GOC:TermGenie GOC:bhm - GO_REF:0000058 + GO_REF:0000058 PMID:25745997 @@ -91156,7 +91004,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of epithelial tube formation. GOC:TermGenie GOC:bhm - GO_REF:0000058 + GO_REF:0000058 PMID:25745997 @@ -91222,7 +91070,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. GOC:TermGenie GOC:bhm - GO_REF:0000058 + GO_REF:0000058 PMID:25745997 @@ -91279,7 +91127,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. GOC:TermGenie GOC:bhm - GO_REF:0000058 + GO_REF:0000058 PMID:25745997 @@ -91384,7 +91232,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. GOC:TermGenie GOC:bhm - GO_REF:0000058 + GO_REF:0000058 PMID:25745997 @@ -91483,7 +91331,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:BHF_telomere GOC:TermGenie GOC:nc - GO_REF:0000058 + GO_REF:0000058 PMID:23201774 @@ -91542,7 +91390,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:BHF_telomere GOC:TermGenie GOC:nc - GO_REF:0000058 + GO_REF:0000058 PMID:23201774 @@ -91649,7 +91497,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:BHF_telomere GOC:TermGenie GOC:nc - GO_REF:0000058 + GO_REF:0000058 PMID:23201774 @@ -91790,22 +91638,22 @@ Note that this term is in the subset of terms that should not be used for direct - - Any process that modulates the frequency, rate or extent of cellular response to gamma radiation. + + regulation of cellular response to gamma-ray photon GOC:TermGenie - GO_REF:0000058 - PMID:23505386 - - regulation of cellular response to gamma ray + + Any process that modulates the frequency, rate or extent of cellular response to gamma radiation. GOC:TermGenie + GO_REF:0000058 + PMID:23505386 - regulation of cellular response to gamma-ray photon + regulation of cellular response to gamma ray GOC:TermGenie @@ -91860,7 +91708,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to gamma radiation. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:23505386 @@ -91999,7 +91847,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of cellular response to gamma radiation. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:23505386 @@ -92125,7 +91973,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:BHF_miRNA GOC:TermGenie GOC:rph - GO_REF:0000058 + GO_REF:0000058 PMID:23939491 @@ -92172,7 +92020,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:BHF_miRNA GOC:TermGenie GOC:rph - GO_REF:0000058 + GO_REF:0000058 PMID:23939491 @@ -92243,7 +92091,7 @@ Note that this term is in the subset of terms that should not be used for direct GOC:BHF_miRNA GOC:TermGenie GOC:rph - GO_REF:0000058 + GO_REF:0000058 PMID:23939491 @@ -92307,7 +92155,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that modulates the frequency, rate or extent of lipid localization. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:17564681 @@ -92362,7 +92210,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:17564681 @@ -92465,7 +92313,7 @@ Note that this term is in the subset of terms that should not be used for direct Any process that activates or increases the frequency, rate or extent of lipid localization. GOC:TermGenie - GO_REF:0000058 + GO_REF:0000058 PMID:17564681 @@ -107533,7 +107381,7 @@ Classes for population already exist in IDO ('organism population', I A plant anatomical entity (PO:0025131) that is, or was, part of a plant, or was derived from a part of a plant. - CARO:0000003 + CARO:0000003 POC:curators @@ -112207,7 +112055,7 @@ Classes for population already exist in IDO ('organism population', I - + Nuclear decay in which an alpha particle is emitted. https://goldbook.iupac.org/terms/view/A00005 http://purl.obolibrary.org/obo/REX_0000017 @@ -112220,7 +112068,7 @@ Classes for population already exist in IDO ('organism population', I - + Radioactive decay in which a beta particle is emitted or in which orbital electron capture occurs. http://goldbook.iupac.org/B00572.html http://purl.obolibrary.org/obo/REX_0000007 @@ -112654,7 +112502,7 @@ Classes for population already exist in IDO ('organism population', I - + An atomic nucleus, fully stripped of its orbital electrons, containing 2 or more protons. Nuclei containing between 2 protons (helium) and 6 protons (carbon) are sometimes referred to as light ions. Jack Miller In RBO--needs def from NCRP Glossary (https://ncrponline.org/wp-content/themes/ncrp/PDFs/NCRP-Composite-Glossary.pdf) @@ -116395,7 +116243,7 @@ Classes for population already exist in IDO ('organism population', I Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism. - UBERONREF:0000003 + UBERONREF:0000003 @@ -141266,7 +141114,7 @@ Classes for population already exist in IDO ('organism population', I An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions. FMA:23217 - UBERONREF:0000003 + UBERONREF:0000003 @@ -143949,7 +143797,7 @@ Classes for population already exist in IDO ('organism population', I - BTO + BTO @@ -144170,7 +144018,7 @@ Classes for population already exist in IDO ('organism population', I - BTO + BTO @@ -149191,7 +149039,7 @@ Classes for population already exist in IDO ('organism population', I - ZFA + ZFA pending @@ -150354,7 +150202,7 @@ Classes for population already exist in IDO ('organism population', I - ZFA + ZFA https://github.com/obophenotype/uberon/issues/378 ABA pending @@ -150363,7 +150211,7 @@ Classes for population already exist in IDO ('organism population', I - ZFA + ZFA ABA pending @@ -157433,7 +157281,7 @@ Classes for population already exist in IDO ('organism population', I Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]. - UBERONREF:0000003 + UBERONREF:0000003 @@ -157990,7 +157838,7 @@ Classes for population already exist in IDO ('organism population', I - ZFA + ZFA pending @@ -158405,7 +158253,7 @@ Classes for population already exist in IDO ('organism population', I - BTO + BTO EHDAA2 GO-def @@ -158769,7 +158617,7 @@ Classes for population already exist in IDO ('organism population', I - BTO + BTO @@ -176729,7 +176577,7 @@ Classes for population already exist in IDO ('organism population', I - BTO + BTO @@ -178781,7 +178629,7 @@ Classes for population already exist in IDO ('organism population', I - BTO + BTO @@ -192301,7 +192149,7 @@ Classes for population already exist in IDO ('organism population', I - BTO + BTO @@ -208930,7 +208778,7 @@ Classes for population already exist in IDO ('organism population', I - BTO + BTO @@ -228107,7 +227955,7 @@ Classes for population already exist in IDO ('organism population', I - BTO + BTO @@ -229213,7 +229061,7 @@ Classes for population already exist in IDO ('organism population', I An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). - UBERONREF:0000003 + UBERONREF:0000003 @@ -242345,7 +242193,7 @@ Classes for population already exist in IDO ('organism population', I A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin. - UBERONREF:0000003 + UBERONREF:0000003 @@ -242357,7 +242205,7 @@ Classes for population already exist in IDO ('organism population', I wing bone - UBERONREF:0000003 + UBERONREF:0000003 @@ -242365,14 +242213,14 @@ Classes for population already exist in IDO ('organism population', I bone of forelimb or pectoral fin or pectoral girdle - UBERONREF:0000003 + UBERONREF:0000003 forelimb bone MA:0000612 - UBERONREF:0000003 + UBERONREF:0000003 @@ -242420,7 +242268,7 @@ Classes for population already exist in IDO ('organism population', I A bone that is part of a pelvic complex. Examples: pubis, ischium, fot phalanx, any tarsal bone, any bone of the pelvic fin or girdle. - UBERONREF:0000003 + UBERONREF:0000003 @@ -242433,7 +242281,7 @@ Classes for population already exist in IDO ('organism population', I hindlimb bone MA:0000660 - UBERONREF:0000003 + UBERONREF:0000003 @@ -269808,6 +269656,12 @@ Classes for population already exist in IDO ('organism population', I + + + + + + @@ -274956,8 +274810,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim m A length unit which is equal to the length of the path traveled by light in vacuum during a time interval of 1/299 792 458 of a second. - meter m + meter metre "A length unit which is equal to the length of the path traveled by light in vacuum during a time interval of 1/299 792 458 of a second." [BIPM:BIPM, NIST:NIST] @@ -274971,8 +274825,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim A mass unit which is equal to the mass of the International Prototype Kilogram kept by the BIPM at Svres, France. - s + s second sec @@ -274994,8 +274848,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim A length unit which is equal to one thousandth of a meter or 10^[-3] m. mm micrometre - millimeter + mm millimeter "A length unit which is equal to one thousandth of a meter or 10^[-3] m." [NIST:NIST] @@ -275061,8 +274915,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim nanogram ng - "A mass unit which is equal to one thousandth of one millionth of a gram or 10^[-9] g." [UOC:GVG] nanogram + "A mass unit which is equal to one thousandth of one millionth of a gram or 10^[-9] g." [UOC:GVG] ng @@ -275094,8 +274948,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim "A time unit which is equal to 60 seconds." [Wikipedia:Wikipedia] - hour + hour h h @@ -275114,8 +274968,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim week "A time unit which is equal to 7 days." [Wikipedia:Wikipedia] - week A time unit which is equal to 7 days. + week @@ -275163,24 +275017,24 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim "A unit of concentration which expresses a concentration of 1 mole of solute per liter of solution (mol/L)." [UOC:GVG] A unit of concentration which expresses a concentration of 1 mole of solute per liter of solution (mol/L). - molar M + molar molar A unit of molarity which is equal to one thousandth of a molar or 10^[-3] M. millimolar mM - millimolar mM + millimolar "A unit of molarity which is equal to one thousandth of a molar or 10^[-3] M." [UOC:GVG] - micromolar uM - uM + micromolar A unit of molarity which is equal to one millionth of a molar or 10^[-6] M. + uM micromolar "A unit of molarity which is equal to one millionth of a molar or 10^[-6] M." [UOC:GVG] @@ -275199,14 +275053,14 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim picomolar "A unit of molarity which is equal to 10^[-12] M." [UOC:GVG] picomolar - A unit of molarity which is equal to 10^[-12] M. - pM + + A unit of molarity which is equal to 10^[-12] M. cubic centimeter - A volume unit which is equal to one millionth of a cubic meter or 10^[-9] m^[3], or to 1 ml. + cubic centimetre cubic centimeter cm^3 @@ -275215,23 +275069,23 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim cc - "A volume unit which is equal to one thousandth of a liter or 10^[-3] L, or to 1 cubic centimeter." [NIST:NIST] milliliter + "A volume unit which is equal to one thousandth of a liter or 10^[-3] L, or to 1 cubic centimeter." [NIST:NIST] ml - A volume unit which is equal to one thousandth of a liter or 10^[-3] L, or to 1 cubic centimeter. millilitre - milliliter + A volume unit which is equal to one thousandth of a liter or 10^[-3] L, or to 1 cubic centimeter. ml + milliliter litre - l L + l A volume unit which is equal to one thousandth of a cubic meter or 10^[-3] m^[3], or to 1 decimeter. - liter "A volume unit which is equal to one thousandth of a cubic meter or 10^[-3] m^[3], or to 1 decimeter." [NIST:NIST] + liter L liter @@ -275248,15 +275102,15 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim microliter microliter ul - A volume unit which is equal to one millionth of a liter or 10^[-6] L. microlitre + A volume unit which is equal to one millionth of a liter or 10^[-6] L. ul "A volume unit which is equal to one millionth of a liter or 10^[-6] L." [NIST:NIST] - nl A volume unit which is equal to one thousandth of one millionth of a liter or 10^[-9] L. + nl nanoliter "A volume unit which is equal to one thousandth of one millionth of a liter or 10^[-9] L." [NIST:NIST] @@ -275278,8 +275132,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim hertz Hz - "A frequency unit which is equal to 1 complete cycle of a recurring phenomenon in 1 second." [NIST:NIST] A frequency unit which is equal to 1 complete cycle of a recurring phenomenon in 1 second. + "A frequency unit which is equal to 1 complete cycle of a recurring phenomenon in 1 second." [NIST:NIST] hertz s^1 @@ -275295,15 +275149,15 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim A dimensionless concentration unit which denotes the mass of a substance in a mixture as a percentage of the mass of the entire mixture. - % w/v - mass volume percentage + + % w/v A dimensionless concentration unit which denotes the mass of the substance in a mixture as a percentage of the volume of the entire mixture. mass volume percentage weight-volume percentage percent vol per vol - "A dimensionless concentration unit which denotes the mass of the substance in a mixture as a percentage of the volume of the entire mixture." [UOC:GVG] (w/v) + "A dimensionless concentration unit which denotes the mass of the substance in a mixture as a percentage of the volume of the entire mixture." [UOC:GVG] % v/v @@ -275331,8 +275185,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim "A mass unit density which is equal to mass of an object in milligrams divided by the volume in milliliters." [UOC:GVG] milligram per milliliter mg per ml - A mass unit density which is equal to mass of an object in milligrams divided by the volume in milliliters. milligram per milliliter + A mass unit density which is equal to mass of an object in milligrams divided by the volume in milliliters. milligram per millilitre mg/ml @@ -275364,18 +275218,18 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim milliliter per liter - "A mass density unit which is equal to mass of an object in grams divided by the volume in deciliters." [UOC:GVG] gram per deciliter + "A mass density unit which is equal to mass of an object in grams divided by the volume in deciliters." [UOC:GVG] g/dl gram per decilitre gram per deciliter - A mass density unit which is equal to mass of an object in grams divided by the volume in deciliters. + A mass density unit which is equal to mass of an object in grams divided by the volume in deciliters. g/dl - colony forming unit per volume + colony forming unit per volume "A concentration unit which a measure of viable bacterial numbers in a given volume." [Wikipedia:Wikipedia] A concentration unit which a measure of viable bacterial numbers in a given volume. @@ -275384,8 +275238,8 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim A volumetric flow rate unit which is equal to one microliter volume through a given surface in one minute. microliters per minute - microlitres per minute uL/min + microlitres per minute "A volumetric flow rate unit which is equal to one microliter volume through a given surface in one minute." [UOC:GVG] microliters per minute @@ -275418,19 +275272,19 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim count per molar 1/M - A rate unit which is equal to one over one molar. count per molar + A rate unit which is equal to one over one molar. "A rate unit which is equal to one over one molar." [UO:GVG] M^-1 - A mass unit density which is equal to mass of an object in micrograms divided by the volume in liters. "A mass unit density which is equal to mass of an object in micrograms divided by the volume in liters." [UOC:GVG] + A mass unit density which is equal to mass of an object in micrograms divided by the volume in liters. ug/L microgram per litre - ng/ml microgram per liter + ng/ml ug/L microgram per liter diff --git a/src/ontology/components/all_templates.owl b/src/ontology/components/all_templates.owl index e070519..4fc331d 100644 --- a/src/ontology/components/all_templates.owl +++ b/src/ontology/components/all_templates.owl @@ -9,7 +9,7 @@ xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + @@ -192,12 +192,6 @@ - - - - - - @@ -3702,7 +3696,7 @@ - + Nuclear decay in which an alpha particle is emitted. https://goldbook.iupac.org/terms/view/A00005 http://purl.obolibrary.org/obo/REX_0000017 @@ -3715,7 +3709,7 @@ - + Radioactive decay in which a beta particle is emitted or in which orbital electron capture occurs. http://goldbook.iupac.org/B00572.html http://purl.obolibrary.org/obo/REX_0000007 diff --git a/src/ontology/imports/bfo_import.owl b/src/ontology/imports/bfo_import.owl index 1f4d7a3..17122c2 100644 --- a/src/ontology/imports/bfo_import.owl +++ b/src/ontology/imports/bfo_import.owl @@ -10,9 +10,9 @@ xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:terms="http://purl.org/dc/terms/"> - + - 2023-12-18 + 2022-10-05 diff --git a/src/ontology/imports/chebi_import.owl b/src/ontology/imports/chebi_import.owl index f81cceb..ccf6460 100644 --- a/src/ontology/imports/chebi_import.owl +++ b/src/ontology/imports/chebi_import.owl @@ -10,8 +10,8 @@ xmlns:chebi="http://purl.obolibrary.org/obo/chebi/" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - 2023-12-18 + + 2023-09-05 @@ -267,7 +267,6 @@ - Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV. -1 0.000548579903 @@ -550,10 +549,8 @@ - - The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes). +1 H @@ -1331,61 +1328,6 @@ - - - - - A monoatomic or polyatomic species having one or more elementary charges of the electron. - Anion - anion - chebi_ontology - Anionen - aniones - anions - CHEBI:22563 - - anion - - - - - Anion - ChEBI - - - - - anion - ChEBI - - - - - anion - IUPAC - - - - - - Anionen - ChEBI - - - - - aniones - ChEBI - - - - - anions - IUPAC - - - - @@ -1611,82 +1553,6 @@ - - - - - Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. - molecular entity - chebi_ontology - entidad molecular - entidades moleculares - entite moleculaire - molecular entities - molekulare Entitaet - CHEBI:23367 - - molecular entity - - - - - molecular entity - IUPAC - - - - - - entidad molecular - IUPAC - - - - - entidades moleculares - IUPAC - - - - - entite moleculaire - IUPAC - - - - - molecular entities - IUPAC - - - - - molekulare Entitaet - ChEBI - - - - - - - - - - chebi_ontology - monoatomic cations - CHEBI:23906 - - monoatomic cation - - - - - monoatomic cations - ChEBI - - - - @@ -1744,25 +1610,6 @@ - - - - A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. - chemical entity - chebi_ontology - CHEBI:24431 - - chemical entity - - - - - chemical entity - UniProt - - - - @@ -1786,7 +1633,6 @@ - @@ -2021,149 +1867,6 @@ - - - - - - chebi_ontology - inorganic anions - CHEBI:24834 - - inorganic anion - - - - - inorganic anions - ChEBI - - - - - - - - - A molecular entity that contains no carbon. - chebi_ontology - anorganische Verbindungen - inorganic compounds - inorganic entity - inorganic molecular entities - inorganics - CHEBI:24835 - - inorganic molecular entity - - - - - anorganische Verbindungen - ChEBI - - - - - inorganic compounds - ChEBI - - - - - inorganic entity - ChEBI - - - - - inorganic molecular entities - ChEBI - - - - - inorganics - ChEBI - - - - - - - - - - chebi_ontology - monoatomic ions - CHEBI:24867 - - monoatomic ion - - - - - monoatomic ions - ChEBI - - - - - - - - - A molecular entity having a net electric charge. - Ion - ion - chebi_ontology - Ionen - iones - ions - CHEBI:24870 - - ion - - - - - Ion - ChEBI - - - - - ion - ChEBI - - - - - ion - IUPAC - - - - - - Ionen - ChEBI - - - - - iones - ChEBI - - - - - ions - ChEBI - - - - @@ -2256,35 +1959,6 @@ - - - - - +1 - 0.00000 - [*+] - chebi_ontology - monoatomic monocations - monovalent inorganic cations - CHEBI:25414 - - monoatomic monocation - - - - - monoatomic monocations - ChEBI - - - - - monovalent inorganic cations - ChEBI - - - - @@ -2438,7 +2112,6 @@ - Any organic ion with a net negative charge. chebi_ontology @@ -2459,7 +2132,6 @@ - chebi_ontology organic ions @@ -2942,7 +2614,6 @@ - @@ -3274,7 +2945,6 @@ - @@ -3337,7 +3007,6 @@ - @@ -3393,7 +3062,6 @@ - Particle of zero charge, zero rest mass, spin quantum number 1, energy hnu and momentum hnu/c (h is the Planck constant, nu the frequency of radiation and c the speed of light), carrier of electromagnetic force. 0 0.0 @@ -3658,45 +3326,6 @@ - - - - - +2 - 0.00000 - [*++] - CHEBI:23856 - CHEBI:4665 - KEGG:C00572 - chebi_ontology - Divalent cation - divalent inorganic cations - monoatomic dications - CHEBI:30412 - - monoatomic dication - - - - - Divalent cation - KEGG_COMPOUND - - - - - divalent inorganic cations - ChEBI - - - - - monoatomic dications - ChEBI - - - - @@ -3741,65 +3370,9 @@ - - - - - A particle not known to have substructure. - elementary particle - chebi_ontology - elementary particles - CHEBI:33233 - - fundamental particle - - - - - elementary particle - IUPAC - - - - - - elementary particles - ChEBI - - - - - - - - - A monoatomic entity is a molecular entity consisting of a single atom. - chebi_ontology - atomic entity - monoatomic entities - CHEBI:33238 - - monoatomic entity - - - - - atomic entity - ChEBI - - - - - monoatomic entities - ChEBI - - - - - chebi_ontology inorganic hydrides @@ -3915,7 +3488,6 @@ - @@ -3992,7 +3564,6 @@ - 0 H @@ -4102,7 +3673,6 @@ - Heavy nuclear particle: proton or neutron. nucleon @@ -4176,45 +3746,9 @@ - - - - - A molecular entity all atoms of which have the same atomic number. - chebi_ontology - homoatomic entity - homoatomic molecular entities - homoatomic molecular entity - CHEBI:33259 - - elemental molecular entity - - - - - homoatomic entity - ChEBI - - - - - homoatomic molecular entities - ChEBI - - - - - homoatomic molecular entity - ChEBI - - - - - - chebi_ontology CHEBI:33260 @@ -4227,7 +3761,6 @@ - An anion consisting of more than one atom. chebi_ontology @@ -4790,7 +4323,6 @@ - 0 He @@ -4814,7 +4346,6 @@ - +2 He @@ -5106,7 +4637,6 @@ - @@ -6095,189 +5625,9 @@ - - - - - - Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin). - chebi_ontology - leptons - CHEBI:36338 - - lepton - - - - - leptons - ChEBI - - - - - - - - - - Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy). - chebi_ontology - baryons - CHEBI:36339 - - baryon - - - - - baryons - ChEBI - - - - - - - - - Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi. - fermion - chebi_ontology - fermions - CHEBI:36340 - - fermion - - - - - fermion - IUPAC - - - - - - fermions - ChEBI - - - - - - - - - Particle of integer spin quantum number following Bose-Einstein statistics. Bosons are named after Satyendra Nath Bose. - boson - chebi_ontology - bosons - CHEBI:36341 - - boson - - - - - boson - IUPAC - - - - - - bosons - ChEBI - - - - - - - - A particle smaller than an atom. - Wikipedia:Subatomic_particle - chebi_ontology - subatomic particles - CHEBI:36342 - - subatomic particle - - - - - subatomic particles - ChEBI - - - - - - - - - A subatomic particle known to have substructure (i.e. consisting of smaller particles). - chebi_ontology - composite particles - CHEBI:36343 - - composite particle - - - - - composite particles - ChEBI - - - - - - - - - Hadron is a subatomic particle which experiences the strong force. - chebi_ontology - hadrons - CHEBI:36344 - - hadron - - - - - hadrons - ChEBI - - - - - - - - - - A hadron with zero or integer spin; a strongly interacting boson. The term is derived from the Greek muepsilonsigmaomicronsigma (medium, middle). - chebi_ontology - mesons - CHEBI:36345 - - meson - - - - - mesons - ChEBI - - - - - A nucleus or any of its constituents in any of their energy states. nuclear particle chebi_ontology @@ -6298,7 +5648,6 @@ - The collective name for zero-spin mesons pi(+), pi(-) and pi(0). pi meson pion @@ -6333,7 +5682,6 @@ - Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.113428913(17) u, or 105.658389(34) MeV. -1 0.113428913 @@ -6391,7 +5739,6 @@ - @@ -6417,7 +5764,6 @@ - An ion consisting of more than one atom. chebi_ontology @@ -6497,111 +5843,6 @@ - - - - - - chebi_ontology - inorganic ions - CHEBI:36914 - - inorganic ion - - - - - inorganic ions - ChEBI - - - - - - - - - - chebi_ontology - inorganic cations - CHEBI:36915 - - inorganic cation - - - - - inorganic cations - ChEBI - - - - - - - - - A monoatomic or polyatomic species having one or more elementary charges of the proton. - CHEBI:23058 - CHEBI:3473 - KEGG:C01373 - Cation - cation - chebi_ontology - Kation - Kationen - cationes - cations - CHEBI:36916 - - cation - - - - - Cation - KEGG_COMPOUND - - - - - cation - ChEBI - - - - - cation - IUPAC - - - - - - Kation - ChEBI - - - - - Kationen - ChEBI - - - - - cationes - ChEBI - - - - - cations - ChEBI - - - - @@ -7247,7 +6488,6 @@ - @@ -7736,26 +6976,6 @@ - - - - - An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one. - chebi_ontology - a monovalent cation - CHEBI:60242 - - monovalent inorganic cation - - - - - a monovalent cation - UniProt - - - - @@ -8685,46 +7905,6 @@ an alpha-amino acid UniProt - - - - - - - - Any inorganic anion with a valency of two. - chebi_ontology - divalent inorganic anions - CHEBI:79388 - - divalent inorganic anion - - - - - divalent inorganic anions - ChEBI - - - - - - - - - Any inorganic anion with a valency of one. - chebi_ontology - monovalent inorganic anions - CHEBI:79389 - - monovalent inorganic anion - - - - - monovalent inorganic anions - ChEBI - diff --git a/src/ontology/imports/chmo_import.owl b/src/ontology/imports/chmo_import.owl index 29aa393..9249194 100644 --- a/src/ontology/imports/chmo_import.owl +++ b/src/ontology/imports/chmo_import.owl @@ -9,12 +9,11 @@ xmlns:xsd="http://www.w3.org/2001/XMLSchema#" xmlns:chmo="http://purl.obolibrary.org/obo/chmo#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" - xmlns:terms="http://purl.org/dc/terms/" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + - 2023-12-18 + 2022-10-05 @@ -110,24 +109,6 @@ - - - - - - - - - - - - - - - - - - @@ -343,7 +324,7 @@ An independent material continuant that is self-connected and retains its identity over time. - https://orcid.org/0000-0001-5985-7429 + https://orcid.org/0000-0001-5985-7429 @@ -360,7 +341,7 @@ A piece of apparatus that is used to measure a physical quantity. - https://orcid.org/0000-0001-5985-7429 + https://orcid.org/0000-0001-5985-7429 @@ -383,7 +364,7 @@ Measurement of the dose of a substance taken up by an object. - https://doi.org/10.1039/9781847559753-00013 + https://doi.org/10.1039/9781847559753-00013 @@ -400,7 +381,7 @@ A sensor that is used to measure the dose of a substance taken by up an object. - https://doi.org/10.1039/9781847559753-00013 + https://doi.org/10.1039/9781847559753-00013 @@ -461,7 +442,7 @@ A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies. - obi:pppb + obi:pppb @@ -498,7 +479,7 @@ A device that is used to generate X-rays. - obi:es + obi:es diff --git a/src/ontology/imports/cob_import.owl b/src/ontology/imports/cob_import.owl index fd7fa5d..8a28d7d 100644 --- a/src/ontology/imports/cob_import.owl +++ b/src/ontology/imports/cob_import.owl @@ -10,8 +10,8 @@ xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:terms="http://purl.org/dc/terms/"> - - 2023-12-18 + + 2022-10-05 @@ -47,18 +47,6 @@ - - - - - - - - - - - - @@ -195,7 +183,7 @@ - + has characteristic https://github.com/oborel/obo-relations/pull/284 @@ -298,53 +286,12 @@ - + realizable - - - - - - - - - - - - - - - - - - - - characteristic - https://github.com/OBOFoundry/COB/issues/65 - https://github.com/oborel/obo-relations/pull/284 - - - - - - - - - - - - - - - We should name the inverse in COB and avoid the confusing inverse(..) construct - - - - @@ -478,7 +425,7 @@ - + http://purl.obolibrary.org/obo/IAO_0000015 Pier 'representational entity' This captures: pattern of writing in a book; neural state in the brain, electronic charges in computer memory etc @@ -615,6 +562,47 @@ + + + + + + + + + + + + + + + + + + + + characteristic + https://github.com/OBOFoundry/COB/issues/65 + https://github.com/oborel/obo-relations/pull/284 + + + + + + + + + + + + + + + We should name the inverse in COB and avoid the confusing inverse(..) construct + + + + diff --git a/src/ontology/imports/doid_import.owl b/src/ontology/imports/doid_import.owl index 2da6f81..ecd53cd 100644 --- a/src/ontology/imports/doid_import.owl +++ b/src/ontology/imports/doid_import.owl @@ -11,7 +11,7 @@ xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + @@ -126,21 +126,21 @@ - A respiratory system disease which involves the lower respiratory tract. - ICD9CM:478.19 - SNOMEDCT_US_2023_03_01:195823002 - UMLS_CUI:C0029581 - disease_ontology - DOID:0050161 + A respiratory system disease which involves the lower respiratory tract. + ICD9CM:478.19 + SNOMEDCT_US_2021_09_01:195823002 + UMLS_CUI:C0029581 + disease_ontology + DOID:0050161 - lower respiratory tract disease + lower respiratory tract disease - A respiratory system disease which involves the lower respiratory tract. + A respiratory system disease which involves the lower respiratory tract. - url:http://en.wikipedia.org/wiki/lower_respiratory_tract + url:http://en.wikipedia.org/wiki/lower_respiratory_tract @@ -149,38 +149,38 @@ - A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle. - lschriml - 2012-01-03T02:54:11Z - ICD10CM:I42 - ICD9CM:425 - ICD9CM:425.9 - MESH:D009202 - NCI:C34830 - NCI:C53654 - SNOMEDCT_US_2023_03_01:266301006 - SNOMEDCT_US_2023_03_01:89461002 - SNOMEDCT_US_2023_03_01:89600009 - UMLS_CUI:C0033141 - UMLS_CUI:C0036529 - UMLS_CUI:C0878544 + A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle. + lschriml + 2012-01-03T02:54:11Z + ICD10CM:I42 + ICD9CM:425 + ICD9CM:425.9 + MESH:D009202 + NCI:C34830 + NCI:C53654 + SNOMEDCT_US_2021_09_01:266301006 + SNOMEDCT_US_2021_09_01:89461002 + SNOMEDCT_US_2021_09_01:89600009 + UMLS_CUI:C0033141 + UMLS_CUI:C0036529 + UMLS_CUI:C0878544 Cardiomyopathies - disease_ontology - DOID:0050700 + disease_ontology + DOID:0050700 - MESH:D009202 added from NeuroDevNet [WAK]. - cardiomyopathy + MESH:D009202 added from NeuroDevNet [WAK]. + cardiomyopathy - A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle. + A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle. - url:http://en.wikipedia.org/wiki/Cardiomyopathy - url:http://www.nhlbi.nih.gov/health/health-topics/topics/cm/ + url:http://en.wikipedia.org/wiki/Cardiomyopathy + url:http://www.nhlbi.nih.gov/health/health-topics/topics/cm/ @@ -189,20 +189,20 @@ - A glomerulonephritis that is characterized by hardening of the glomerulus in the kidney. - lschriml - 2014-04-15T03:40:31Z - disease_ontology - DOID:0050851 + A glomerulonephritis that is characterized by hardening of the glomerulus in the kidney. + lschriml + 2014-04-15T03:40:31Z + disease_ontology + DOID:0050851 - glomerulosclerosis + glomerulosclerosis - A glomerulonephritis that is characterized by hardening of the glomerulus in the kidney. + A glomerulonephritis that is characterized by hardening of the glomerulus in the kidney. - url:http://en.wikipedia.org/wiki/Glomerulosclerosis + url:http://en.wikipedia.org/wiki/Glomerulosclerosis @@ -211,52 +211,49 @@ - An infratentorial cancer that is located_in the lower part of the brain and is a type of primitive neuroectodermal tumor. - lschriml - 2014-10-06T14:36:37Z - DOID:0060105 - DOID:168 - DOID:3858 - DOID:4981 - GARD:7005 - ICDO:9470/3 - MESH:D008527 - MESH:D018242 - NCI:C27294 - NCI:C3222 - NCI:C3716 - OMIM:155255 - ORDO:616 - SNOMEDCT_US_2023_03_01:189925001 - SNOMEDCT_US_2023_03_01:443333004 - UMLS_CUI:C0025149 - UMLS_CUI:C0206663 - UMLS_CUI:C1334410 + An infratentorial cancer that is located_in the lower part of the brain and is a type of primitive neuroectodermal tumor. + lschriml + 2014-10-06T14:36:37Z + DOID:0060105 + DOID:168 + DOID:3858 + DOID:4981 + GARD:7005 + ICDO:9470/3 + MESH:D008527 + MESH:D018242 + NCI:C27294 + NCI:C3222 + NCI:C3716 + OMIM:155255 + SNOMEDCT_US_2021_09_01:189925001 + SNOMEDCT_US_2021_09_01:443333004 + UMLS_CUI:C0025149 + UMLS_CUI:C0206663 + UMLS_CUI:C1334410 CNS PNET CPNET - Medulloblastoma, histologically defined brain medulloblastoma infratentorial primitive neuroectodermal tumor localized primitive neuroectodermal tumor - disease_ontology - DOID:0050902 + disease_ontology + DOID:0050902 - - OMIM mapping confirmed by DO. [SN]. - medulloblastoma + OMIM mapping confirmed by DO. [SN]. + medulloblastoma - An infratentorial cancer that is located_in the lower part of the brain and is a type of primitive neuroectodermal tumor. + An infratentorial cancer that is located_in the lower part of the brain and is a type of primitive neuroectodermal tumor. - url:http://en.wikipedia.org/wiki/Medulloblastoma - url:http://www.cancer.gov/dictionary?CdrID=45780 - url:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306779/ + url:http://en.wikipedia.org/wiki/Medulloblastoma + url:http://www.cancer.gov/dictionary?CdrID=45780 + url:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306779/ @@ -265,18 +262,18 @@ - A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development. - disease_ontology - DOID:0060037 + A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development. + disease_ontology + DOID:0060037 - developmental disorder of mental health + developmental disorder of mental health - A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development. + A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development. - url:http://en.wikipedia.org/wiki/Developmental_disorders + url:http://en.wikipedia.org/wiki/Developmental_disorders @@ -285,35 +282,35 @@ - A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs. - DOID:1033 - DOID:353 - ICD10CM:C85.9 - ICDO:9590/3 - MESH:D008223 - NCI:C3208 - NCI:C7065 - SNOMEDCT_US_2023_03_01:118600007 - SNOMEDCT_US_2023_03_01:414628006 - UMLS_CUI:C0024299 - UMLS_CUI:C0598798 + A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs. + DOID:1033 + DOID:353 + ICD10CM:C85.9 + ICDO:9590/3 + MESH:D008223 + NCI:C3208 + NCI:C7065 + SNOMEDCT_US_2021_09_01:118600007 + SNOMEDCT_US_2021_09_01:414628006 + UMLS_CUI:C0024299 + UMLS_CUI:C0598798 lymphoid cancer - disease_ontology - DOID:0060058 + disease_ontology + DOID:0060058 - lymphoma + lymphoma - A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs. + A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs. - url:http://en.wikipedia.org/wiki/Lymphoma - url:http://www.lymphoma.org/site/pp.asp?c=bkLTKaOQLmK8E&b=6300161 - url:http://www.nlm.nih.gov/medlineplus/lymphoma.html + url:http://en.wikipedia.org/wiki/Lymphoma + url:http://www.lymphoma.org/site/pp.asp?c=bkLTKaOQLmK8E&b=6300161 + url:http://www.nlm.nih.gov/medlineplus/lymphoma.html @@ -322,24 +319,24 @@ - A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer. - lschriml - 2011-05-11T12:18:41Z - disease_ontology - DOID:0060071 + A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer. + lschriml + 2011-05-11T12:18:41Z + disease_ontology + DOID:0060071 - pre-malignant neoplasm + pre-malignant neoplasm - A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer. + A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer. - url:http://en.wikipedia.org/wiki/Neoplasm + url:http://en.wikipedia.org/wiki/Neoplasm @@ -349,26 +346,26 @@ - A disease of cellular proliferation that results in abnormal growths in the body which lack the ability to metastasize. - lschriml - 2011-05-11T12:18:41Z - disease_ontology - DOID:0060072 + A disease of cellular proliferation that results in abnormal growths in the body which lack the ability to metastasize. + lschriml + 2011-05-11T12:18:41Z + disease_ontology + DOID:0060072 - benign neoplasm + benign neoplasm - A disease of cellular proliferation that results in abnormal growths in the body which lack the ability to metastasize. + A disease of cellular proliferation that results in abnormal growths in the body which lack the ability to metastasize. - url:http://en.wikipedia.org/wiki/Benign_neoplasm - url:http://www.nlm.nih.gov/medlineplus/benigntumors.html + url:http://en.wikipedia.org/wiki/Benign_neoplasm + url:http://www.nlm.nih.gov/medlineplus/benigntumors.html @@ -377,26 +374,26 @@ - An eye disease that affects the cornea, which is the transparent surface of the eye that assists in light refraction. - DOID:2284 - ICD10CM:H18.9 - ICD9CM:371.9 - MESH:D003316 - NCI:C26731 - SNOMEDCT_US_2023_03_01:15250008 - UMLS_CUI:C0010034 - disease_ontology - DOID:10124 + An eye disease that affects the cornea, which is the transparent surface of the eye that assists in light refraction. + DOID:2284 + ICD10CM:H18.9 + ICD9CM:371.9 + MESH:D003316 + NCI:C26731 + SNOMEDCT_US_2021_09_01:15250008 + UMLS_CUI:C0010034 + disease_ontology + DOID:10124 - corneal disease + corneal disease - An eye disease that affects the cornea, which is the transparent surface of the eye that assists in light refraction. + An eye disease that affects the cornea, which is the transparent surface of the eye that assists in light refraction. - url:https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26731 + url:https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C26731 @@ -405,22 +402,22 @@ - A cardiovascular system disease that involves the heart's electrical conduction system. - ICD9CM:426.6 - SNOMEDCT_US_2023_03_01:195053008 - UMLS_CUI:C0029630 + A cardiovascular system disease that involves the heart's electrical conduction system. + ICD9CM:426.6 + SNOMEDCT_US_2021_09_01:195053008 + UMLS_CUI:C0029630 heart rhythm disease - disease_ontology - DOID:10273 + disease_ontology + DOID:10273 - heart conduction disease + heart conduction disease - A cardiovascular system disease that involves the heart's electrical conduction system. + A cardiovascular system disease that involves the heart's electrical conduction system. - url:http://en.wikipedia.org/wiki/Conduction_system_of_the_heart + url:http://en.wikipedia.org/wiki/Conduction_system_of_the_heart @@ -429,27 +426,27 @@ - A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. - EFO:0001663 - KEGG:05215 - NCI:C4863 - SNOMEDCT_US_2023_03_01:254900004 - UMLS_CUI:C0600139 + A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. + EFO:0001663 + KEGG:05215 + NCI:C4863 + SNOMEDCT_US_2021_09_01:254900004 + UMLS_CUI:C0600139 cancer of prostate carcinoma of prostate - disease_ontology - DOID:10286 + disease_ontology + DOID:10286 - prostate carcinoma + prostate carcinoma - A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. + A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. - url:http://en.wikipedia.org/wiki/Carcinoma + url:http://en.wikipedia.org/wiki/Carcinoma @@ -458,31 +455,31 @@ - A leukemia that has_material_basis_in a B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. - DOID:10747 - ICD10CM:C91 - ICD9CM:204 - ICDO:9820/3 - MESH:D007945 - NCI:C7539 - SNOMEDCT_US_2023_03_01:93170002 - UMLS_CUI:C0023448 + A leukemia that has_material_basis_in a B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. + DOID:10747 + ICD10CM:C91 + ICD9CM:204 + ICDO:9820/3 + MESH:D007945 + NCI:C7539 + SNOMEDCT_US_2021_09_01:93170002 + UMLS_CUI:C0023448 lymphoblastic leukaemia lymphoblastic leukemia lymphocytic leukaemia - disease_ontology - DOID:1037 + disease_ontology + DOID:1037 - lymphoid leukemia + lymphoid leukemia - A leukemia that has_material_basis_in a B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. + A leukemia that has_material_basis_in a B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. - url:http://www.cancer.gov/dictionary?CdrID=616067 + url:http://www.cancer.gov/dictionary?CdrID=616067 @@ -491,22 +488,22 @@ - A lymphocytic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood. - EFO:0000095 - GARD:6104 - ICD10CM:C91.10 - ICD9CM:204.1 - MESH:D015451 - NCI:C3163 - OMIM:109543 - OMIM:151400 - OMIM:609630 - OMIM:612557 - OMIM:612558 - OMIM:612559 - ORDO:67038 - SNOMEDCT_US_2023_03_01:51092000 - UMLS_CUI:C0023434 + A lymphocytic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood. + EFO:0000095 + GARD:6104 + ICD10CM:C91.10 + ICD9CM:204.1 + MESH:D015451 + NCI:C3163 + OMIM:109543 + OMIM:151400 + OMIM:609630 + OMIM:612557 + OMIM:612558 + OMIM:612559 + ORDO:67038 + SNOMEDCT_US_2021_09_01:51092000 + UMLS_CUI:C0023434 B-cell chronic lymphocytic leukaemia B-cell chronic lymphocytic leukemia CLL @@ -515,25 +512,25 @@ chronic lymphocytic leukaemia lymphoplasmacytic leukaemia lymphoplasmacytic leukemia - disease_ontology + disease_ontology B-cell chronic lymphoid leukemia - DOID:1040 + DOID:1040 - Xref MGI. - chronic lymphocytic leukemia + Xref MGI. + chronic lymphocytic leukemia - A lymphocytic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood. + A lymphocytic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood. - url:http://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia - url:http://www.cancer.gov/dictionary?cdrid=346545 + url:http://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia + url:http://www.cancer.gov/dictionary?cdrid=346545 @@ -542,55 +539,54 @@ - A gastrointestinal system cancer that is located_in the stomach. - DOID:10539 - DOID:10542 - DOID:10543 - DOID:4713 - GARD:7704 - ICD10CM:C16 - ICD10CM:C16.2 - ICD10CM:C16.5 - ICD10CM:C16.6 - ICD9CM:151 - ICD9CM:151.4 - ICD9CM:151.5 - ICD9CM:151.6 - MESH:D013274 - NCI:C3387 - NCI:C9331 - OMIM:613659 - SNOMEDCT_US_2023_03_01:126824007 - SNOMEDCT_US_2023_03_01:269459004 - SNOMEDCT_US_2023_03_01:269460009 - SNOMEDCT_US_2023_03_01:93717002 - SNOMEDCT_US_2023_03_01:94074003 - UMLS_CUI:C0024623 - UMLS_CUI:C0038356 - UMLS_CUI:C0153421 - UMLS_CUI:C0153422 - UMLS_CUI:C0153423 + A gastrointestinal system cancer that is located_in the stomach. + DOID:10539 + DOID:10542 + DOID:10543 + DOID:4713 + GARD:7704 + ICD10CM:C16 + ICD10CM:C16.2 + ICD10CM:C16.5 + ICD10CM:C16.6 + ICD9CM:151 + ICD9CM:151.4 + ICD9CM:151.5 + ICD9CM:151.6 + MESH:D013274 + NCI:C3387 + NCI:C9331 + OMIM:613659 + SNOMEDCT_US_2021_09_01:126824007 + SNOMEDCT_US_2021_09_01:269459004 + SNOMEDCT_US_2021_09_01:269460009 + SNOMEDCT_US_2021_09_01:93717002 + SNOMEDCT_US_2021_09_01:94074003 + UMLS_CUI:C0024623 + UMLS_CUI:C0038356 + UMLS_CUI:C0153421 + UMLS_CUI:C0153422 + UMLS_CUI:C0153423 gastric cancer gastric neoplasm - disease_ontology - DOID:10534 + disease_ontology + DOID:10534 - - OMIM mapping confirmed by DO. [SN]. - stomach cancer + OMIM mapping confirmed by DO. [SN]. + stomach cancer - A gastrointestinal system cancer that is located_in the stomach. + A gastrointestinal system cancer that is located_in the stomach. - url:http://cancergenome.nih.gov/cancersselected/stomach-esophagealcancer - url:http://en.wikipedia.org/wiki/Stomach + url:http://cancergenome.nih.gov/cancersselected/stomach-esophagealcancer + url:http://en.wikipedia.org/wiki/Stomach @@ -599,38 +595,37 @@ - A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. - EFO:0000249 - GARD:10254 - ICD10CM:G30 - ICD9CM:331.0 - KEGG:05010 - MESH:D000544 - NCI:C2866 - SNOMEDCT_US_2023_03_01:73768007 - UMLS_CUI:C0002395 + A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. + EFO:0000249 + GARD:10254 + ICD10CM:G30 + ICD9CM:331.0 + KEGG:05010 + MESH:D000544 + NCI:C2866 + SNOMEDCT_US_2021_09_01:73768007 + UMLS_CUI:C0002395 Alzheimer disease Alzheimers dementia - disease_ontology - DOID:10652 + disease_ontology + DOID:10652 - - Xref MGI. + Xref MGI. OMIM mapping confirmed by DO. [SN]. - Alzheimer's disease + Alzheimer's disease - A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. + A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. - url:http://en.wikipedia.org/wiki/Alzheimer%27s_disease - url:http://www.merriam-webster.com/medical/alzheimer%27s%20disease - url:http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet - ls:IEDB + url:http://en.wikipedia.org/wiki/Alzheimer%27s_disease + url:http://www.merriam-webster.com/medical/alzheimer%27s%20disease + url:http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet + ls:IEDB @@ -639,39 +634,38 @@ OMIM mapping confirmed by DO. [SN]. - An urinary system cancer that results_in malignant growth located_in the urinary bladder. - DOID:5428 - GARD:12210 - ICD10CM:C67 - ICD9CM:188 - KEGG:05219 - MESH:D001749 - NCI:C2901 - NCI:C9334 - OMIM:109800 - SNOMEDCT_US_2023_03_01:126885006 - SNOMEDCT_US_2023_03_01:363455001 - UMLS_CUI:C0005684 - UMLS_CUI:C0005695 + An urinary system cancer that results_in malignant growth located_in the urinary bladder. + DOID:5428 + GARD:12210 + ICD10CM:C67 + ICD9CM:188 + KEGG:05219 + MESH:D001749 + NCI:C2901 + NCI:C9334 + OMIM:109800 + SNOMEDCT_US_2021_09_01:126885006 + SNOMEDCT_US_2021_09_01:363455001 + UMLS_CUI:C0005684 + UMLS_CUI:C0005695 bladder cancer tumor of the bladder - disease_ontology - DOID:11054 + disease_ontology + DOID:11054 - - OMIM mapping confirmed by DO. [SN]. - urinary bladder cancer + OMIM mapping confirmed by DO. [SN]. + urinary bladder cancer - An urinary system cancer that results_in malignant growth located_in the urinary bladder. + An urinary system cancer that results_in malignant growth located_in the urinary bladder. - url:http://en.wikipedia.org/wiki/Bladder_cancer + url:http://en.wikipedia.org/wiki/Bladder_cancer @@ -680,32 +674,32 @@ OMIM mapping confirmed by DO. [SN]. - A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm. - DOID:3936 - ICD10CM:C49 - ICD9CM:171.9 - ICDO:8800/3 - SNOMEDCT_US_2023_03_01:93765001 - UMLS_CUI:C0153519 + A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm. + DOID:3936 + ICD10CM:C49 + ICD9CM:171.9 + ICDO:8800/3 + SNOMEDCT_US_2021_09_01:93765001 + UMLS_CUI:C0153519 connective and soft tissue neoplasm tumor of soft tissue and skeleton - disease_ontology - DOID:1115 + disease_ontology + DOID:1115 - sarcoma + sarcoma - A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm. + A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm. - url:http://cancergenome.nih.gov/cancersselected/Sarcoma - url:http://en.wikipedia.org/wiki/Sarcoma - url:http://www.cancer.gov/dictionary?CdrID=45562 + url:http://cancergenome.nih.gov/cancersselected/Sarcoma + url:http://en.wikipedia.org/wiki/Sarcoma + url:http://www.cancer.gov/dictionary?CdrID=45562 @@ -714,26 +708,26 @@ OMIM mapping confirmed by DO. [SN]. - A cardiovascular system disease that involves the heart. - ICD10CM:I51.9 - ICD9CM:429.9 - MESH:D006331 - NCI:C3079 - SNOMEDCT_US_2023_03_01:194707003 - UMLS_CUI:C0018799 - disease_ontology - DOID:114 + A cardiovascular system disease that involves the heart. + ICD10CM:I51.9 + ICD9CM:429.9 + MESH:D006331 + NCI:C3079 + SNOMEDCT_US_2021_09_01:194707003 + UMLS_CUI:C0018799 + disease_ontology + DOID:114 - heart disease + heart disease - A cardiovascular system disease that involves the heart. + A cardiovascular system disease that involves the heart. - url:http://en.wikipedia.org/wiki/Heart_disease + url:http://en.wikipedia.org/wiki/Heart_disease @@ -742,23 +736,23 @@ OMIM mapping confirmed by DO. [SN]. - A lower respiratory tract disease that affects the airways leading into the lungs, which is caused due to inflammation of the bronchi and bronchioles, infection, or blockage. - DOID:1175 - DOID:12322 - MESH:D001982 - SNOMEDCT_US_2023_03_01:41427001 - UMLS_CUI:C0006261 - disease_ontology - DOID:1176 + A lower respiratory tract disease that affects the airways leading into the lungs, which is caused due to inflammation of the bronchi and bronchioles, infection, or blockage. + DOID:1175 + DOID:12322 + MESH:D001982 + SNOMEDCT_US_2021_09_01:41427001 + UMLS_CUI:C0006261 + disease_ontology + DOID:1176 - bronchial disease + bronchial disease - A lower respiratory tract disease that affects the airways leading into the lungs, which is caused due to inflammation of the bronchi and bronchioles, infection, or blockage. + A lower respiratory tract disease that affects the airways leading into the lungs, which is caused due to inflammation of the bronchi and bronchioles, infection, or blockage. - url:https://www.ncbi.nlm.nih.gov/pubmed/11685087 + url:https://www.ncbi.nlm.nih.gov/pubmed/11685087 @@ -767,31 +761,31 @@ OMIM mapping confirmed by DO. [SN]. - A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells. - DOID:9145 - ICD10CM:C95.90 - ICD9CM:208 - ICDO:9800/3 - MESH:D007938 - NCI:C3161 - SNOMEDCT_US_2023_03_01:255049003 - UMLS_CUI:C0023418 - disease_ontology - DOID:1240 + A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells. + DOID:9145 + ICD10CM:C95.90 + ICD9CM:208 + ICDO:9800/3 + MESH:D007938 + NCI:C3161 + SNOMEDCT_US_2021_09_01:255049003 + UMLS_CUI:C0023418 + disease_ontology + DOID:1240 - leukemia + leukemia - A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells. + A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells. - url:http://en.wikipedia.org/wiki/Leukemia - url:http://www.cancer.gov/dictionary?CdrID=45343 + url:http://en.wikipedia.org/wiki/Leukemia + url:http://www.cancer.gov/dictionary?CdrID=45343 @@ -800,31 +794,31 @@ OMIM mapping confirmed by DO. [SN]. - A hematopoietic system disease that is characterized by abnormal blood clotting or bleeding. - DOID:13997 - DOID:2212 - DOID:9474 - ICD10CM:D68.9 - ICD9CM:286 - MESH:D001778 - NCI:C2902 - SNOMEDCT_US_2023_03_01:64779008 - UMLS_CUI:C0005779 - coagulation protein disease + A hematopoietic system disease that is characterized by abnormal blood clotting or bleeding. + DOID:13997 + DOID:2212 + DOID:9474 + ICD10CM:D68.9 + ICD9CM:286 + MESH:D001778 + NCI:C2902 + SNOMEDCT_US_2021_09_01:64779008 + UMLS_CUI:C0005779 + coagulation protein disease postpartum coagulation defect postpartum coagulation defect with delivery - inherited blood coagulation disease - disease_ontology - DOID:1247 + inherited blood coagulation disease + disease_ontology + DOID:1247 - blood coagulation disease + blood coagulation disease - A hematopoietic system disease that is characterized by abnormal blood clotting or bleeding. - url:https://www.cedars-sinai.edu/Patients/Health-Conditions/Coagulation-System-Disorders.aspx + A hematopoietic system disease that is characterized by abnormal blood clotting or bleeding. + url:https://www.cedars-sinai.edu/Patients/Health-Conditions/Coagulation-System-Disorders.aspx @@ -833,30 +827,30 @@ OMIM mapping confirmed by DO. [SN]. - A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. - DOID:73 - ICD9CM:429.2 - MESH:D002318 - NCI:C2931 - SNOMEDCT_US_2023_03_01:266275004 - UMLS_CUI:C0007222 + A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. + DOID:73 + ICD9CM:429.2 + MESH:D002318 + NCI:C2931 + SNOMEDCT_US_2021_09_01:266275004 + UMLS_CUI:C0007222 disease of subdivision of hemolymphoid system - disease_ontology - DOID:1287 + disease_ontology + DOID:1287 - cardiovascular system disease + cardiovascular system disease - A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. + A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. - url:http://en.wikipedia.org/wiki/Circulatory_system + url:http://en.wikipedia.org/wiki/Circulatory_system @@ -865,20 +859,20 @@ OMIM mapping confirmed by DO. [SN]. - A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior. - ICD9CM:290.8 - UMLS_CUI:C0154319 - disease_ontology - DOID:1307 + A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior. + ICD9CM:290.8 + UMLS_CUI:C0154319 + disease_ontology + DOID:1307 - dementia + dementia - A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior. + A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior. - url:http://www.nlm.nih.gov/medlineplus/ency/article/000739.htm + url:http://www.nlm.nih.gov/medlineplus/ency/article/000739.htm @@ -887,30 +881,30 @@ OMIM mapping confirmed by DO. [SN]. - A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain. - DOID:2125 - DOID:2126 - DOID:3543 - DOID:6649 - DOID:911 - ICD10CM:C71 - ICD9CM:191 - ICD9CM:239.6 - MESH:D001932 - NCI:C170814 - NCI:C2907 - NCI:C3568 - NCI:C5115 - NCI:C7710 - SNOMEDCT_US_2023_03_01:126952004 - SNOMEDCT_US_2023_03_01:428061005 - SNOMEDCT_US_2023_03_01:93727008 - UMLS_CUI:C0006118 - UMLS_CUI:C0153633 - UMLS_CUI:C0220624 - UMLS_CUI:C0750974 - UMLS_CUI:C0750979 - UMLS_CUI:C1334557 + A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain. + DOID:2125 + DOID:2126 + DOID:3543 + DOID:6649 + DOID:911 + ICD10CM:C71 + ICD9CM:191 + ICD9CM:239.6 + MESH:D001932 + NCI:C170814 + NCI:C2907 + NCI:C3568 + NCI:C5115 + NCI:C7710 + SNOMEDCT_US_2021_09_01:126952004 + SNOMEDCT_US_2021_09_01:428061005 + SNOMEDCT_US_2021_09_01:93727008 + UMLS_CUI:C0006118 + UMLS_CUI:C0153633 + UMLS_CUI:C0220624 + UMLS_CUI:C0750974 + UMLS_CUI:C0750979 + UMLS_CUI:C1334557 BT - Brain tumour adult brain tumor adult malignant brain neoplasm @@ -926,23 +920,23 @@ OMIM mapping confirmed by DO. [SN]. primary brain tumor primary malignant neoplasm of brain tumor of the Brain - disease_ontology - DOID:1319 + disease_ontology + DOID:1319 - brain cancer + brain cancer - A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain. + A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain. - url:http://www.cancer.gov/dictionary?CdrID=387264 + url:http://www.cancer.gov/dictionary?CdrID=387264 @@ -951,24 +945,23 @@ OMIM mapping confirmed by DO. [SN]. - A brain disease that is characterized by loss of structure or function of neurons, including death of neurons and loss of brain tissue. - GARD:6019 - ICD9CM:331.9 - SNOMEDCT_US_2023_03_01:52522001 - UMLS_CUI:C0154671 + A brain disease that is characterized by loss of structure or function of neurons, including death of neurons and loss of brain tissue. + GARD:6019 + ICD9CM:331.9 + SNOMEDCT_US_2021_09_01:52522001 + UMLS_CUI:C0154671 Brain degeneration - disease_ontology - DOID:1443 + disease_ontology + DOID:1443 - - cerebral degeneration + cerebral degeneration - A brain disease that is characterized by loss of structure or function of neurons, including death of neurons and loss of brain tissue. + A brain disease that is characterized by loss of structure or function of neurons, including death of neurons and loss of brain tissue. - url:https://en.wikipedia.org/wiki/Neurodegeneration + url:https://en.wikipedia.org/wiki/Neurodegeneration @@ -977,23 +970,23 @@ OMIM mapping confirmed by DO. [SN]. - A disease that is characterized by abnormally rapid cell division. - neoplasm - DOID:0000818 + A disease that is characterized by abnormally rapid cell division. + neoplasm + DOID:0000818 cell process disease neoplasm - disease_ontology - DOID:14566 + disease_ontology + DOID:14566 - disease of cellular proliferation + disease of cellular proliferation - A disease that is characterized by abnormally rapid cell division. + A disease that is characterized by abnormally rapid cell division. - url:http://en.wikipedia.org/w/index.php?title=Cell_proliferation + url:http://en.wikipedia.org/w/index.php?title=Cell_proliferation @@ -1002,28 +995,28 @@ OMIM mapping confirmed by DO. [SN]. - A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture. - ICD10CM:F99 - MESH:D001523 - NCI:C2893 - SNOMEDCT_US_2023_03_01:74732009 - UMLS_CUI:C0004936 - disease_ontology - DOID:150 + A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture. + ICD10CM:F99 + MESH:D001523 + NCI:C2893 + SNOMEDCT_US_2021_09_01:74732009 + UMLS_CUI:C0004936 + disease_ontology + DOID:150 - disease of mental health + disease of mental health - A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture. + A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture. - url:http://en.wikipedia.org/wiki/Mental_disorder + url:http://en.wikipedia.org/wiki/Mental_disorder @@ -1032,22 +1025,22 @@ OMIM mapping confirmed by DO. [SN]. - A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work. - ICD9CM:301.8 - SNOMEDCT_US_2023_03_01:191770003 - UMLS_CUI:C0029707 + A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work. + ICD9CM:301.8 + SNOMEDCT_US_2021_09_01:191770003 + UMLS_CUI:C0029707 character disorder - disease_ontology - DOID:1510 + disease_ontology + DOID:1510 - personality disorder + personality disorder - A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work. + A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work. - url:http://www.nlm.nih.gov/medlineplus/personalitydisorders.html + url:http://www.nlm.nih.gov/medlineplus/personalitydisorders.html @@ -1056,26 +1049,26 @@ OMIM mapping confirmed by DO. [SN]. - A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism. - DOID:1531 - MESH:D010995 - NCI:C26859 - SNOMEDCT_US_2023_03_01:88075009 - UMLS_CUI:C0032226 + A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism. + DOID:1531 + MESH:D010995 + NCI:C26859 + SNOMEDCT_US_2021_09_01:88075009 + UMLS_CUI:C0032226 disorder of pleura non-neoplastic pleural disease - disease_ontology - DOID:1532 + disease_ontology + DOID:1532 - pleural disease + pleural disease - A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism. + A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism. - url:http://en.wikipedia.org/wiki/Pleural_disease + url:http://en.wikipedia.org/wiki/Pleural_disease @@ -1084,26 +1077,26 @@ OMIM mapping confirmed by DO. [SN]. - A disease of mental health that affects cognitive functions including memory processing, perception and problem solving. - ICD10CM:F09 - MESH:D019965 - NCI:C34870 - SNOMEDCT_US_2023_03_01:111479008 - UMLS_CUI:C0029227 + A disease of mental health that affects cognitive functions including memory processing, perception and problem solving. + ICD10CM:F09 + MESH:D019965 + NCI:C34870 + SNOMEDCT_US_2021_09_01:111479008 + UMLS_CUI:C0029227 cognitive disease - disease_ontology + disease_ontology Organic Mental disorder - DOID:1561 + DOID:1561 - cognitive disorder + cognitive disorder - A disease of mental health that affects cognitive functions including memory processing, perception and problem solving. + A disease of mental health that affects cognitive functions including memory processing, perception and problem solving. - url:http://en.wikipedia.org/wiki/Cognitive_disorder + url:http://en.wikipedia.org/wiki/Cognitive_disorder @@ -1112,29 +1105,29 @@ OMIM mapping confirmed by DO. [SN]. - A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm. - DOID:3226 - ICD10CM:J98 - ICD9CM:519 - SNOMEDCT_US_2023_03_01:155603009 - UMLS_CUI:C0029582 - disease_ontology - DOID:1579 + A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm. + DOID:3226 + ICD10CM:J98 + ICD9CM:519 + SNOMEDCT_US_2021_09_01:155603009 + UMLS_CUI:C0029582 + disease_ontology + DOID:1579 - respiratory system disease + respiratory system disease - A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm. + A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm. - url:http://en.wikipedia.org/wiki/File:Respiratory_system_complete_en.svg - url:http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=respiratory%20system + url:http://en.wikipedia.org/wiki/File:Respiratory_system_complete_en.svg + url:http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=respiratory%20system @@ -1143,44 +1136,44 @@ OMIM mapping confirmed by DO. [SN]. - A thoracic cancer that originates in the mammary gland. - DOID:1648 - DOID:4241 - ICD10CM:C50 - MESH:D001943 - NCI:C9335 - OMIM:114480 - SNOMEDCT_US_2023_03_01:254837009 - UMLS_CUI:C0006142 + A thoracic cancer that originates in the mammary gland. + DOID:1648 + DOID:4241 + ICD10CM:C50 + MESH:D001943 + NCI:C9335 + OMIM:114480 + SNOMEDCT_US_2021_09_01:254837009 + UMLS_CUI:C0006142 breast tumor malignant neoplasm of breast malignant tumor of the breast mammary cancer mammary tumor primary breast cancer - disease_ontology + disease_ontology mammary neoplasm - DOID:1612 + DOID:1612 - Xref MGI. + Xref MGI. OMIM mapping confirmed by DO. [SN]. - breast cancer + breast cancer - A thoracic cancer that originates in the mammary gland. + A thoracic cancer that originates in the mammary gland. - url:http://en.wikipedia.org/wiki/Breast_cancer - url:http://en.wikipedia.org/wiki/Mammary - url:http://www.cancer.gov/cancertopics/types/breast - url:http://www.nlm.nih.gov/medlineplus/breastcancer.html + url:http://en.wikipedia.org/wiki/Breast_cancer + url:http://en.wikipedia.org/wiki/Mammary + url:http://www.cancer.gov/cancertopics/types/breast + url:http://www.nlm.nih.gov/medlineplus/breastcancer.html @@ -1189,19 +1182,19 @@ OMIM mapping confirmed by DO. [SN]. - A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. - ICD10CM:C80.1 - ICD9CM:199 - ICDO:8000/3 - MESH:D009369 - NCI:C9305 - SNOMEDCT_US_2023_03_01:269513004 - UMLS_CUI:C0006826 + A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. + ICD10CM:C80.1 + ICD9CM:199 + ICDO:8000/3 + MESH:D009369 + NCI:C9305 + SNOMEDCT_US_2021_09_01:269513004 + UMLS_CUI:C0006826 malignant neoplasm malignant tumor primary cancer - disease_ontology - DOID:162 + disease_ontology + DOID:162 @@ -1209,17 +1202,17 @@ OMIM mapping confirmed by DO. [SN]. - Updating out dated UMLS CUI. - cancer + Updating out dated UMLS CUI. + cancer - A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. + A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. - url:http://en.wikipedia.org/wiki/cancer - url:http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer + url:http://en.wikipedia.org/wiki/cancer + url:http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=cancer @@ -1228,41 +1221,41 @@ OMIM mapping confirmed by DO. [SN]. - A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart. - DOID:0000405 - DOID:2403 - DOID:2869 - DOID:324 - DOID:325 - DOID:45 - ICD10CM:I72.9 - ICD9CM:442.9 - MESH:D000783 - MESH:D014652 - MESH:D020758 - MESH:D020760 - NCI:C26693 - NCI:C35117 - SNOMEDCT_US_2023_03_01:27550009 - SNOMEDCT_US_2023_03_01:371029002 - SNOMEDCT_US_2023_03_01:432119003 - UMLS_CUI:C0002940 - UMLS_CUI:C0042373 - UMLS_CUI:C0752127 - UMLS_CUI:C0752130 + A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart. + DOID:0000405 + DOID:2403 + DOID:2869 + DOID:324 + DOID:325 + DOID:45 + ICD10CM:I72.9 + ICD9CM:442.9 + MESH:D000783 + MESH:D014652 + MESH:D020758 + MESH:D020760 + NCI:C26693 + NCI:C35117 + SNOMEDCT_US_2021_09_01:27550009 + SNOMEDCT_US_2021_09_01:371029002 + SNOMEDCT_US_2021_09_01:432119003 + UMLS_CUI:C0002940 + UMLS_CUI:C0042373 + UMLS_CUI:C0752127 + UMLS_CUI:C0752130 vascular tissue disease - disease_ontology - DOID:178 + disease_ontology + DOID:178 - vascular disease + vascular disease - A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart. + A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart. - url:http://en.wikipedia.org/wiki/Vascular_disease + url:http://en.wikipedia.org/wiki/Vascular_disease @@ -1271,23 +1264,23 @@ OMIM mapping confirmed by DO. [SN]. - A pericardium disease that is characterized by an inflammation of the pericardium and has_symptom chest pain. - MESH:D010493 - NCI:C34915 - SNOMEDCT_US_2023_03_01:3238004 - UMLS_CUI:C0031046 - disease_ontology - DOID:1787 + A pericardium disease that is characterized by an inflammation of the pericardium and has_symptom chest pain. + MESH:D010493 + NCI:C34915 + SNOMEDCT_US_2021_09_01:3238004 + UMLS_CUI:C0031046 + disease_ontology + DOID:1787 - pericarditis + pericarditis - A pericardium disease that is characterized by an inflammation of the pericardium and has_symptom chest pain. + A pericardium disease that is characterized by an inflammation of the pericardium and has_symptom chest pain. - url:http://en.wikipedia.org/wiki/Pericarditis + url:http://en.wikipedia.org/wiki/Pericarditis @@ -1296,33 +1289,33 @@ OMIM mapping confirmed by DO. [SN]. - A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye. - EFO:0000756 - ICDO:8720/3 - KEGG:05218 - MESH:D008545 - NCI:C3224 - SNOMEDCT_US_2023_03_01:2092003 - UMLS_CUI:C0025202 + A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye. + EFO:0000756 + ICDO:8720/3 + KEGG:05218 + MESH:D008545 + NCI:C3224 + SNOMEDCT_US_2021_09_01:2092003 + UMLS_CUI:C0025202 Naevocarcinoma malignant melanoma - disease_ontology - DOID:1909 + disease_ontology + DOID:1909 - melanoma - MESH:D008545 + melanoma + MESH:D008545 - A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye. + A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye. - url:http://en.wikipedia.org/wiki/Melanoma - url:https://www.ncbi.nlm.nih.gov/pubmed/22123420 + url:http://en.wikipedia.org/wiki/Melanoma + url:https://www.ncbi.nlm.nih.gov/pubmed/22123420 @@ -1331,19 +1324,19 @@ OMIM mapping confirmed by DO. [SN]. - EFO:0003914 - ICD10CM:I70 - ICD9CM:440 - MESH:D050197 - NCI:C35768 - SNOMEDCT_US_2023_03_01:155414001 - UMLS_CUI:C0004153 - disease_ontology - DOID:1936 + EFO:0003914 + ICD10CM:I70 + ICD9CM:440 + MESH:D050197 + NCI:C35768 + SNOMEDCT_US_2021_09_01:155414001 + UMLS_CUI:C0004153 + disease_ontology + DOID:1936 - atherosclerosis - MESH:D050197 + atherosclerosis + MESH:D050197 @@ -1352,28 +1345,28 @@ OMIM mapping confirmed by DO. [SN]. - A cognitive disorder that involves an excessive, irrational dread of everyday situations. - DOID:12884 - ICD10CM:F41.9 - MESH:D001008 - NCI:C2878 - OMIM:607834 - SNOMEDCT_US_2023_03_01:65673007 - UMLS_CUI:C0003469 + A cognitive disorder that involves an excessive, irrational dread of everyday situations. + DOID:12884 + ICD10CM:F41.9 + MESH:D001008 + NCI:C2878 + OMIM:607834 + SNOMEDCT_US_2021_09_01:65673007 + UMLS_CUI:C0003469 anxiety anxiety state - disease_ontology - DOID:2030 + disease_ontology + DOID:2030 - anxiety disorder + anxiety disorder - A cognitive disorder that involves an excessive, irrational dread of everyday situations. + A cognitive disorder that involves an excessive, irrational dread of everyday situations. - url:http://www.nimh.nih.gov/health/topics/anxiety-disorders/index.shtml + url:http://www.nimh.nih.gov/health/topics/anxiety-disorders/index.shtml @@ -1382,34 +1375,34 @@ OMIM mapping confirmed by DO. [SN]. - A female reproductive organ cancer that is located_in the ovary. - DOID:0060070 - DOID:2144 - DOID:9595 - GARD:7295 - ICD10CM:C56 - ICD9CM:183.0 - MESH:D010051 - NCI:C4984 - NCI:C7431 - OMIM:167000 - OMIM:607893 - ORDO:213500 - ORDO:213517 - SNOMEDCT_US_2023_03_01:123843001 - SNOMEDCT_US_2023_03_01:372117006 - SNOMEDCT_US_2023_03_01:93934004 - UMLS_CUI:C0919267 - UMLS_CUI:C1140680 - UMLS_CUI:C1299247 + A female reproductive organ cancer that is located_in the ovary. + DOID:0060070 + DOID:2144 + DOID:9595 + GARD:7295 + ICD10CM:C56 + ICD9CM:183.0 + MESH:D010051 + NCI:C4984 + NCI:C7431 + OMIM:167000 + OMIM:607893 + ORDO:213500 + ORDO:213517 + SNOMEDCT_US_2021_09_01:123843001 + SNOMEDCT_US_2021_09_01:372117006 + SNOMEDCT_US_2021_09_01:93934004 + UMLS_CUI:C0919267 + UMLS_CUI:C1140680 + UMLS_CUI:C1299247 malignant Ovarian tumor malignant tumour of ovary ovarian neoplasm ovary neoplasm primary ovarian cancer tumor of the Ovary - disease_ontology - DOID:2394 + disease_ontology + DOID:2394 @@ -1417,17 +1410,17 @@ OMIM mapping confirmed by DO. [SN]. - Xref MGI. + Xref MGI. OMIM mapping confirmed by DO. [SN]. - ovarian cancer + ovarian cancer - A female reproductive organ cancer that is located_in the ovary. + A female reproductive organ cancer that is located_in the ovary. - url:http://www.cancer.gov/dictionary?CdrID=445074 + url:http://www.cancer.gov/dictionary?CdrID=445074 @@ -1436,15 +1429,15 @@ OMIM mapping confirmed by DO. [SN]. - MESH:D007499 - NCI:C34737 - SNOMEDCT_US_2023_03_01:85478004 - UMLS_CUI:C0022078 - disease_ontology - DOID:240 + MESH:D007499 + NCI:C34737 + SNOMEDCT_US_2021_09_01:85478004 + UMLS_CUI:C0022078 + disease_ontology + DOID:240 - iris disease + iris disease @@ -1453,22 +1446,22 @@ OMIM mapping confirmed by DO. [SN]. - A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality. - EFO:0000677 - ICD9CM:298.8 - UMLS_CUI:C0029516 + A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality. + EFO:0000677 + ICD9CM:298.8 + UMLS_CUI:C0029516 mental or behavioural disorder - disease_ontology - DOID:2468 + disease_ontology + DOID:2468 - psychotic disorder + psychotic disorder - A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality. + A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality. - url:http://www.nlm.nih.gov/medlineplus/psychoticdisorders.html + url:http://www.nlm.nih.gov/medlineplus/psychoticdisorders.html @@ -1477,22 +1470,22 @@ OMIM mapping confirmed by DO. [SN]. - A skin carcinoma affecting basal cells. - DOID:4275 - DOID:4276 - EFO:0004193 - ICDO:8090/3 - KEGG:05217 - MESH:D018295 - NCI:C156767 - NCI:C3784 - NCI:C7586 - SNOMEDCT_US_2023_03_01:127570002 - SNOMEDCT_US_2023_03_01:154507009 - SNOMEDCT_US_2023_03_01:252995000 - UMLS_CUI:C0007117 - UMLS_CUI:C0206710 - UMLS_CUI:C1368295 + A skin carcinoma affecting basal cells. + DOID:4275 + DOID:4276 + EFO:0004193 + ICDO:8090/3 + KEGG:05217 + MESH:D018295 + NCI:C156767 + NCI:C3784 + NCI:C7586 + SNOMEDCT_US_2021_09_01:127570002 + SNOMEDCT_US_2021_09_01:154507009 + SNOMEDCT_US_2021_09_01:252995000 + UMLS_CUI:C0007117 + UMLS_CUI:C0206710 + UMLS_CUI:C1368295 Basal cell cancer Basal cell carcinoma of skin Basal cell neoplasm @@ -1501,20 +1494,20 @@ OMIM mapping confirmed by DO. [SN]. Rodent ulcer malignant Basal cell neoplasm malignant basal cell tumor - disease_ontology - DOID:2513 + disease_ontology + DOID:2513 - Xref MGI. - basal cell carcinoma + Xref MGI. + basal cell carcinoma - A skin carcinoma affecting basal cells. + A skin carcinoma affecting basal cells. - url:http://en.wikipedia.org/wiki/Basal-cell_carcinoma + url:http://en.wikipedia.org/wiki/Basal-cell_carcinoma @@ -1523,13 +1516,13 @@ OMIM mapping confirmed by DO. [SN]. - An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes. - DOID:1034 - DOID:2532 - MESH:D019337 - NCI:C27134 - SNOMEDCT_US_2023_03_01:414388001 - UMLS_CUI:C0376544 + An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes. + DOID:1034 + DOID:2532 + MESH:D019337 + NCI:C27134 + SNOMEDCT_US_2021_09_01:414388001 + UMLS_CUI:C0376544 Hematologic malignancy Hematologic neoplasm Hematological tumors @@ -1539,25 +1532,25 @@ OMIM mapping confirmed by DO. [SN]. hematopoietic neoplasm hematopoietic tumors malignant hematopoietic neoplasm - disease_ontology - DOID:2531 + disease_ontology + DOID:2531 - hematologic cancer + hematologic cancer - An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes. + An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes. - url:http://en.wikipedia.org/wiki/Blood_cancer - url:http://www.cancer.gov/dictionary/?CdrID=45708 + url:http://en.wikipedia.org/wiki/Blood_cancer + url:http://www.cancer.gov/dictionary/?CdrID=45708 @@ -1566,23 +1559,23 @@ OMIM mapping confirmed by DO. [SN]. - A brain disease that is characterized by damage to brain substance located_in cerebellum; has_symptom ataxia, has_symptom dysarthria, and has_symptom cerebellar cognitive affective syndrome. - MESH:D002526 - SNOMEDCT_US_2023_03_01:267691001 - UMLS_CUI:C0007760 - disease_ontology - DOID:2786 + A brain disease that is characterized by damage to brain substance located_in cerebellum; has_symptom ataxia, has_symptom dysarthria, and has_symptom cerebellar cognitive affective syndrome. + MESH:D002526 + SNOMEDCT_US_2021_09_01:267691001 + UMLS_CUI:C0007760 + disease_ontology + DOID:2786 - cerebellar disease + cerebellar disease - A brain disease that is characterized by damage to brain substance located_in cerebellum; has_symptom ataxia, has_symptom dysarthria, and has_symptom cerebellar cognitive affective syndrome. + A brain disease that is characterized by damage to brain substance located_in cerebellum; has_symptom ataxia, has_symptom dysarthria, and has_symptom cerebellar cognitive affective syndrome. - url:https://en.wikipedia.org/wiki/Cerebellum - url:https://www.ncbi.nlm.nih.gov/pubmed/15377747 + url:https://en.wikipedia.org/wiki/Cerebellum + url:https://www.ncbi.nlm.nih.gov/pubmed/15377747 @@ -1591,29 +1584,29 @@ OMIM mapping confirmed by DO. [SN]. - A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body. - ICD10CM:E34.9 - ICD9CM:259.9 - MESH:D004700 - NCI:C3009 - SNOMEDCT_US_2023_03_01:67432001 - UMLS_CUI:C0014130 - disease_ontology - DOID:28 + A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body. + ICD10CM:E34.9 + ICD9CM:259.9 + MESH:D004700 + NCI:C3009 + SNOMEDCT_US_2021_09_01:67432001 + UMLS_CUI:C0014130 + disease_ontology + DOID:28 - endocrine system disease + endocrine system disease - A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body. + A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body. - url:http://en.wikipedia.org/wiki/Endocrine_system + url:http://en.wikipedia.org/wiki/Endocrine_system @@ -1622,27 +1615,26 @@ OMIM mapping confirmed by DO. [SN]. - A nephritis that causes inflammation of the glomeruli located_in kidney. - GARD:6516 - ICD10CM:N08 - MESH:D005921 - NCI:C26784 - SNOMEDCT_US_2023_03_01:36171008 - UMLS_CUI:C0017658 - disease_ontology - DOID:2921 + A nephritis that causes inflammation of the glomeruli located_in kidney. + GARD:6516 + ICD10CM:N08 + MESH:D005921 + NCI:C26784 + SNOMEDCT_US_2021_09_01:36171008 + UMLS_CUI:C0017658 + disease_ontology + DOID:2921 - - glomerulonephritis + glomerulonephritis - A nephritis that causes inflammation of the glomeruli located_in kidney. + A nephritis that causes inflammation of the glomeruli located_in kidney. - url:http://en.wikipedia.org/wiki/Glomerulonephritis - sn:IEDB + url:http://en.wikipedia.org/wiki/Glomerulonephritis + sn:IEDB @@ -1651,27 +1643,27 @@ OMIM mapping confirmed by DO. [SN]. - A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from germ cells. - DOID:2157 - MESH:D009373 - NCI:C3708 - SNOMEDCT_US_2023_03_01:302853003 - UMLS_CUI:C0205851 + A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from germ cells. + DOID:2157 + MESH:D009373 + NCI:C3708 + SNOMEDCT_US_2021_09_01:302853003 + UMLS_CUI:C0205851 malignant tumor of the germ cell - disease_ontology + disease_ontology germ cell neoplasm germ cell tumour - DOID:2994 + DOID:2994 - germ cell cancer + germ cell cancer - A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from germ cells. + A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from germ cells. - url:http://en.wikipedia.org/wiki/Germ_cell_tumor + url:http://en.wikipedia.org/wiki/Germ_cell_tumor @@ -1680,21 +1672,21 @@ OMIM mapping confirmed by DO. [SN]. - A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning. - MESH:D019966 - NCI:C92203 - UMLS_CUI:C0236969 - disease_ontology - DOID:303 + A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning. + MESH:D019966 + NCI:C92203 + UMLS_CUI:C0236969 + disease_ontology + DOID:303 - substance-related disorder + substance-related disorder - A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning. - url:https://www.psychologytoday.com/us/conditions/substance-related-disorders + A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning. + url:https://www.psychologytoday.com/us/conditions/substance-related-disorders @@ -1703,34 +1695,32 @@ OMIM mapping confirmed by DO. [SN]. - An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both. - DOID:11500 - DOID:6144 - EFO:0000341 - ICD10CM:J44.9 - MESH:D029424 - NCI:C3199 - OMIM:606963 - SNOMEDCT_US_2023_03_01:13645005 - UMLS_CUI:C0024117 + An obstructive lung disease that is characterized by irreversible airflow obstruction due to chronic bronchitis, emphysema, and/or small airways disease. + DOID:11500 + DOID:6144 + EFO:0000341 + ICD10CM:J44.9 + MESH:D029424 + NCI:C3199 + OMIM:606963 + SNOMEDCT_US_2021_09_01:13645005 + UMLS_CUI:C0024117 COLD COPD chronic obstructive airway disease chronic obstructive lung disease - disease_ontology - DOID:3083 + disease_ontology + DOID:3083 - chronic obstructive pulmonary disease + chronic obstructive pulmonary disease - An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both. - url:https://pubmed.ncbi.nlm.nih.gov/28513453/ - url:https://pubmed.ncbi.nlm.nih.gov/32745458/ - url:https://pubmed.ncbi.nlm.nih.gov/32800196/ - url:https://www.nhlbi.nih.gov/health-topics/copd + An obstructive lung disease that is characterized by irreversible airflow obstruction due to chronic bronchitis, emphysema, and/or small airways disease. + url:https://pubmed.ncbi.nlm.nih.gov/28513453/ + url:https://www.nhlbi.nih.gov/health-topics/copd @@ -1739,57 +1729,57 @@ OMIM mapping confirmed by DO. [SN]. - An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. - DOID:10506 - DOID:3363 - DOID:3394 - DOID:9420 - EFO:0001645 - ICD10CM:I20-I25 - ICD10CM:I25 - ICD10CM:I25.10 - ICD9CM:410-414.99 - ICD9CM:414.0 - ICD9CM:414.9 - MESH:D003324 - MESH:D003327 - MESH:D017202 - NCI:C35505 - NCI:C50625 - OMIM:300464 - OMIM:607339 - OMIM:608316 - OMIM:608318 - OMIM:608320 - OMIM:610947 - OMIM:611139 - OMIM:612030 - OMIM:614293 - SNOMEDCT_US_2023_03_01:194852007 - SNOMEDCT_US_2023_03_01:233822007 - SNOMEDCT_US_2023_03_01:41702007 - SNOMEDCT_US_2023_03_01:53741008 - UMLS_CUI:C0010054 - UMLS_CUI:C0010068 - UMLS_CUI:C0151744 - UMLS_CUI:C0264694 + An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. + DOID:10506 + DOID:3363 + DOID:3394 + DOID:9420 + EFO:0001645 + ICD10CM:I20-I25 + ICD10CM:I25 + ICD10CM:I25.10 + ICD9CM:410-414.99 + ICD9CM:414.0 + ICD9CM:414.9 + MESH:D003324 + MESH:D003327 + MESH:D017202 + NCI:C35505 + NCI:C50625 + OMIM:300464 + OMIM:607339 + OMIM:608316 + OMIM:608318 + OMIM:608320 + OMIM:610947 + OMIM:611139 + OMIM:612030 + OMIM:614293 + SNOMEDCT_US_2021_09_01:194852007 + SNOMEDCT_US_2021_09_01:233822007 + SNOMEDCT_US_2021_09_01:41702007 + SNOMEDCT_US_2021_09_01:53741008 + UMLS_CUI:C0010054 + UMLS_CUI:C0010068 + UMLS_CUI:C0151744 + UMLS_CUI:C0264694 CHD Coronary disease coronary arteriosclerosis coronary heart disease - disease_ontology - DOID:3393 + disease_ontology + DOID:3393 - Xref MGI. - coronary artery disease + Xref MGI. + coronary artery disease - An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. + An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. - url:http://en.wikipedia.org/wiki/Coronary_heart_disease + url:http://en.wikipedia.org/wiki/Coronary_heart_disease @@ -1798,22 +1788,22 @@ OMIM mapping confirmed by DO. [SN]. - A skin cancer that is located_in tissues of the skin and develops from epithelial cells. - NCI:C4914 - UMLS_CUI:C0699893 + A skin cancer that is located_in tissues of the skin and develops from epithelial cells. + NCI:C4914 + UMLS_CUI:C0699893 carcinoma of skin - disease_ontology - DOID:3451 + disease_ontology + DOID:3451 - skin carcinoma + skin carcinoma - A skin cancer that is located_in tissues of the skin and develops from epithelial cells. + A skin cancer that is located_in tissues of the skin and develops from epithelial cells. - url:http://www.cancer.gov/cancertopics/types/skin + url:http://www.cancer.gov/cancertopics/types/skin @@ -1822,28 +1812,29 @@ OMIM mapping confirmed by DO. [SN]. - A hepatobiliary system cancer that is located_in the liver. - DOID:12300 - DOID:269 - DOID:7330 - DOID:915 - DOID:919 - ICD10CM:C22.0 - ICD10CM:C22.9 - ICD9CM:155.0 - ICD9CM:155.2 - MESH:D008113 - NCI:C34803 - NCI:C7692 - SNOMEDCT_US_2023_03_01:126851005 - SNOMEDCT_US_2023_03_01:187771009 - SNOMEDCT_US_2023_03_01:93870000 - UMLS_CUI:C0023903 - UMLS_CUI:C0024620 - UMLS_CUI:C0345904 - UMLS_CUI:C0854795 + A hepatobiliary system cancer that is located_in the liver. + DOID:12300 + DOID:269 + DOID:7330 + DOID:915 + DOID:919 + ICD10CM:C22.0 + ICD10CM:C22.9 + ICD9CM:155.0 + ICD9CM:155.2 + MESH:D008113 + NCI:C34803 + NCI:C7692 + SNOMEDCT_US_2021_09_01:126851005 + SNOMEDCT_US_2021_09_01:187771009 + SNOMEDCT_US_2021_09_01:93870000 + UMLS_CUI:C0023903 + UMLS_CUI:C0024620 + UMLS_CUI:C0345904 + UMLS_CUI:C0854795 Ca liver - primary Resectable malignant neoplasm of Liver + ca liver - primary hepatic cancer hepatic neoplasm malignant hepato-biliary neoplasm @@ -1854,23 +1845,24 @@ OMIM mapping confirmed by DO. [SN]. neoplasm of liver non-resectable primary hepatic malignant neoplasm primary liver cancer + primary malignant neoplasm of Liver primary malignant neoplasm of liver resectable malignant neoplasm of the liver - disease_ontology - DOID:3571 + disease_ontology + DOID:3571 - liver cancer + liver cancer - A hepatobiliary system cancer that is located_in the liver. + A hepatobiliary system cancer that is located_in the liver. - url:http://en.wikipedia.org/wiki/Liver + url:http://en.wikipedia.org/wiki/Liver @@ -1879,37 +1871,37 @@ OMIM mapping confirmed by DO. [SN]. - An integumentary system disease that is located_in skin. - DOID:1576 - DOID:1698 - DOID:187 - DOID:6486 - DOID:8948 - ICD9CM:702 - MESH:D012871 - MESH:D012873 - NCI:C156032 - NCI:C3371 - SNOMEDCT_US_2023_03_01:201095006 - SNOMEDCT_US_2023_03_01:5613003 - SNOMEDCT_US_2023_03_01:95320005 - UMLS_CUI:C0029574 - UMLS_CUI:C0037274 - UMLS_CUI:C0037277 + An integumentary system disease that is located_in skin. + DOID:1576 + DOID:1698 + DOID:187 + DOID:6486 + DOID:8948 + ICD9CM:702 + MESH:D012871 + MESH:D012873 + NCI:C156032 + NCI:C3371 + SNOMEDCT_US_2021_09_01:201095006 + SNOMEDCT_US_2021_09_01:5613003 + SNOMEDCT_US_2021_09_01:95320005 + UMLS_CUI:C0029574 + UMLS_CUI:C0037274 + UMLS_CUI:C0037277 Genodermatosis skin and subcutaneous tissue disease - disease_ontology - DOID:37 + disease_ontology + DOID:37 - skin disease + skin disease - An integumentary system disease that is located_in skin. + An integumentary system disease that is located_in skin. - url:http://en.wikipedia.org/wiki/Skin_disease + url:http://en.wikipedia.org/wiki/Skin_disease @@ -1917,23 +1909,23 @@ OMIM mapping confirmed by DO. [SN]. - A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. - MESH:D004194 - NCI:C2991 - SNOMEDCT_US_2023_03_01:64572001 - UMLS_CUI:C0012634 - disease_ontology - DOID:4 + A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. + MESH:D004194 + NCI:C2991 + SNOMEDCT_US_2021_09_01:64572001 + UMLS_CUI:C0012634 + disease_ontology + DOID:4 - disease + disease - A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. + A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. - url:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041577/ + url:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041577/ @@ -1942,23 +1934,23 @@ OMIM mapping confirmed by DO. [SN]. - A gastrointestinal system disease that is located_in the mouth. - MESH:D009059 - NCI:C27641 - SNOMEDCT_US_2023_03_01:118938008 - UMLS_CUI:C0026636 - disease_ontology - DOID:403 + A gastrointestinal system disease that is located_in the mouth. + MESH:D009059 + NCI:C27641 + SNOMEDCT_US_2021_09_01:118938008 + UMLS_CUI:C0026636 + disease_ontology + DOID:403 - mouth disease + mouth disease - A gastrointestinal system disease that is located_in the mouth. + A gastrointestinal system disease that is located_in the mouth. - url:http://en.wikipedia.org/wiki/Oral_and_maxillofacial_pathology + url:http://en.wikipedia.org/wiki/Oral_and_maxillofacial_pathology @@ -1967,28 +1959,28 @@ OMIM mapping confirmed by DO. [SN]. - A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right). - DOID:989 - MESH:D006349 - MESH:D016127 - NCI:C45525 - SNOMEDCT_US_2023_03_01:368009 - SNOMEDCT_US_2023_03_01:398995000 - UMLS_CUI:C0018824 - UMLS_CUI:C0079485 + A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right). + DOID:989 + MESH:D006349 + MESH:D016127 + NCI:C45525 + SNOMEDCT_US_2021_09_01:368009 + SNOMEDCT_US_2021_09_01:398995000 + UMLS_CUI:C0018824 + UMLS_CUI:C0079485 Valvular heart disease - disease_ontology - DOID:4079 + disease_ontology + DOID:4079 - heart valve disease + heart valve disease - A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right). + A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right). - url:http://en.wikipedia.org/wiki/Heart_valve_disease + url:http://en.wikipedia.org/wiki/Heart_valve_disease @@ -1997,22 +1989,22 @@ OMIM mapping confirmed by DO. [SN]. - DOID:2164 - DOID:2165 - DOID:46 - ICD10CM:K76.9 - ICD9CM:573.9 - MESH:D008107 - NCI:C3196 - SNOMEDCT_US_2023_03_01:62857009 - UMLS_CUI:C0023895 + DOID:2164 + DOID:2165 + DOID:46 + ICD10CM:K76.9 + ICD9CM:573.9 + MESH:D008107 + NCI:C3196 + SNOMEDCT_US_2021_09_01:62857009 + UMLS_CUI:C0023895 disorder of liver hepatic disorder - disease_ontology - DOID:409 + disease_ontology + DOID:409 - liver disease + liver disease @@ -2021,34 +2013,34 @@ OMIM mapping confirmed by DO. [SN]. - A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate. - DOID:10133 - DOID:144 - ICD10CM:F45 - ICD10CM:F45.0 - ICD9CM:300.8 - ICD9CM:300.81 - MESH:D013001 - NCI:C34956 - SNOMEDCT_US_2023_03_01:192430009 - SNOMEDCT_US_2023_03_01:60368009 - UMLS_CUI:C0037650 - UMLS_CUI:C0520482 + A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate. + DOID:10133 + DOID:144 + ICD10CM:F45 + ICD10CM:F45.0 + ICD9CM:300.8 + ICD9CM:300.81 + MESH:D013001 + NCI:C34956 + SNOMEDCT_US_2021_09_01:192430009 + SNOMEDCT_US_2021_09_01:60368009 + UMLS_CUI:C0037650 + UMLS_CUI:C0520482 physiological malfunction arising from mental factor psychophysiologic disorder psychosomatic disorder - disease_ontology - DOID:4737 + disease_ontology + DOID:4737 - somatoform disorder + somatoform disorder - A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate. + A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate. - url:http://en.wikipedia.org/wiki/Somatoform_disorder + url:http://en.wikipedia.org/wiki/Somatoform_disorder @@ -2057,24 +2049,17 @@ OMIM mapping confirmed by DO. [SN]. - A hematopoietic system disease that is located_in the bone marrow. - MESH:D001855 - NCI:C34433 - SNOMEDCT_US_2023_03_01:127035006 - UMLS_CUI:C0005956 + MESH:D001855 + NCI:C34433 + SNOMEDCT_US_2021_09_01:127035006 + UMLS_CUI:C0005956 bone marrow disorder - disease_ontology - DOID:4961 + disease_ontology + DOID:4961 - bone marrow disease + bone marrow disease - - - - A hematopoietic system disease that is located_in the bone marrow. - url:https://medlineplus.gov/bonemarrowdiseases.html - @@ -2082,40 +2067,40 @@ OMIM mapping confirmed by DO. [SN]. - A gastrointestinal system cancer that is located_in the esophagus. - DOID:10291 - DOID:10292 - DOID:10448 - DOID:1102 - DOID:1104 - GARD:6383 - ICD10CM:C15.3 - ICD10CM:C15.4 - ICD10CM:C15.5 - ICD9CM:150.2 - ICD9CM:150.3 - ICD9CM:150.4 - ICD9CM:150.5 - ICD9CM:150.8 - MESH:D004938 - NCI:C3028 - NCI:C3533 - NCI:C3534 - NCI:C3535 - NCI:C4764 - OMIM:133239 - SNOMEDCT_US_2023_03_01:126817006 - SNOMEDCT_US_2023_03_01:187729008 - SNOMEDCT_US_2023_03_01:93656003 - SNOMEDCT_US_2023_03_01:93877002 - SNOMEDCT_US_2023_03_01:93895004 - SNOMEDCT_US_2023_03_01:94119000 - UMLS_CUI:C0014859 - UMLS_CUI:C0153413 - UMLS_CUI:C0153414 - UMLS_CUI:C0153415 - UMLS_CUI:C0153416 - UMLS_CUI:C0496775 + A gastrointestinal system cancer that is located_in the esophagus. + DOID:10291 + DOID:10292 + DOID:10448 + DOID:1102 + DOID:1104 + GARD:6383 + ICD10CM:C15.3 + ICD10CM:C15.4 + ICD10CM:C15.5 + ICD9CM:150.2 + ICD9CM:150.3 + ICD9CM:150.4 + ICD9CM:150.5 + ICD9CM:150.8 + MESH:D004938 + NCI:C3028 + NCI:C3533 + NCI:C3534 + NCI:C3535 + NCI:C4764 + OMIM:133239 + SNOMEDCT_US_2021_09_01:126817006 + SNOMEDCT_US_2021_09_01:187729008 + SNOMEDCT_US_2021_09_01:93656003 + SNOMEDCT_US_2021_09_01:93877002 + SNOMEDCT_US_2021_09_01:93895004 + SNOMEDCT_US_2021_09_01:94119000 + UMLS_CUI:C0014859 + UMLS_CUI:C0153413 + UMLS_CUI:C0153414 + UMLS_CUI:C0153415 + UMLS_CUI:C0153416 + UMLS_CUI:C0496775 Ca lower third oesophagus Ca middle third oesophagus esophagus cancer @@ -2128,23 +2113,22 @@ OMIM mapping confirmed by DO. [SN]. malignant tumor of Proximal Third of esophagus malignant tumor of abdominal esophagus malignant tumor of the middle Third of the esophagus - disease_ontology - DOID:5041 + disease_ontology + DOID:5041 - - esophageal cancer + esophageal cancer - A gastrointestinal system cancer that is located_in the esophagus. + A gastrointestinal system cancer that is located_in the esophagus. - url:http://cancergenome.nih.gov/cancersselected/stomach-esophagealcancer - url:http://en.wikipedia.org/wiki/Esophagus + url:http://cancergenome.nih.gov/cancersselected/stomach-esophagealcancer + url:http://en.wikipedia.org/wiki/Esophagus @@ -2153,23 +2137,23 @@ OMIM mapping confirmed by DO. [SN]. - A disease of mental health that involves disruption of sleep patterns. - DOID:9028 - ICD9CM:307.4 - UMLS_CUI:C0154564 + A disease of mental health that involves disruption of sleep patterns. + DOID:9028 + ICD9CM:307.4 + UMLS_CUI:C0154564 Non-organic sleep disorder - disease_ontology - DOID:535 + disease_ontology + DOID:535 - sleep disorder + sleep disorder - A disease of mental health that involves disruption of sleep patterns. + A disease of mental health that involves disruption of sleep patterns. - url:http://en.wikipedia.org/wiki/Sleep_disorder + url:http://en.wikipedia.org/wiki/Sleep_disorder @@ -2178,22 +2162,22 @@ OMIM mapping confirmed by DO. [SN]. - A intestinal disease located in the colon. - DOID:10758 - MESH:D003108 - SNOMEDCT_US_2023_03_01:128524007 - UMLS_CUI:C0009373 + A intestinal disease located in the colon. + DOID:10758 + MESH:D003108 + SNOMEDCT_US_2021_09_01:128524007 + UMLS_CUI:C0009373 colon disorder - disease_ontology - DOID:5353 + disease_ontology + DOID:5353 - colonic disease + colonic disease - A intestinal disease located in the colon. - url:https://www.nature.com/subjects/colonic-diseases + A intestinal disease located in the colon. + url:https://www.nature.com/subjects/colonic-diseases @@ -2202,29 +2186,29 @@ OMIM mapping confirmed by DO. [SN]. - A urinary system disease that is located_in the kidney. - DOID:11705 - EFO:0003086 - ICD10CM:N08 - MESH:D007674 - NCI:C3149 - SNOMEDCT_US_2023_03_01:266612003 - UMLS_CUI:C0022658 - impaired renal function disease + A urinary system disease that is located_in the kidney. + DOID:11705 + EFO:0003086 + ICD10CM:N08 + MESH:D007674 + NCI:C3149 + SNOMEDCT_US_2021_09_01:266612003 + UMLS_CUI:C0022658 + impaired renal function disease nephropathy - disease_ontology - DOID:557 + disease_ontology + DOID:557 - kidney disease + kidney disease - A urinary system disease that is located_in the kidney. + A urinary system disease that is located_in the kidney. - url:http://www.nlm.nih.gov/medlineplus/kidneydiseases.html + url:http://www.nlm.nih.gov/medlineplus/kidneydiseases.html @@ -2233,27 +2217,27 @@ OMIM mapping confirmed by DO. [SN]. - An eye and adnexa disease that is located_in the eye. - DOID:2933 - ICD10CM:H44 - ICD9CM:379.90 - MESH:D005128 - NCI:C26767 - SNOMEDCT_US_2023_03_01:371409005 - UMLS_CUI:C0015397 - disease_ontology - DOID:5614 + An eye and adnexa disease that is located_in the eye. + DOID:2933 + ICD10CM:H44 + ICD9CM:379.90 + MESH:D005128 + NCI:C26767 + SNOMEDCT_US_2021_09_01:371409005 + UMLS_CUI:C0015397 + disease_ontology + DOID:5614 - eye disease + eye disease - An eye and adnexa disease that is located_in the eye. + An eye and adnexa disease that is located_in the eye. - url:http://en.wikipedia.org/wiki/Eye_disease + url:http://en.wikipedia.org/wiki/Eye_disease @@ -2262,23 +2246,23 @@ OMIM mapping confirmed by DO. [SN]. - A sarcoma and hematologic cancer that derives_from follicular lymphoma. - NCI:C9294 - UMLS_CUI:C1334030 + A sarcoma and hematologic cancer that derives_from follicular lymphoma. + NCI:C9294 + UMLS_CUI:C1334030 histiocytic and dendritic cell - disease_ontology - DOID:5621 + disease_ontology + DOID:5621 - histiocytic and dendritic cell cancer + histiocytic and dendritic cell cancer - A sarcoma and hematologic cancer that derives_from follicular lymphoma. + A sarcoma and hematologic cancer that derives_from follicular lymphoma. - url:http://www.springerlink.com/content/h9wrn7p72x26q035/ + url:http://www.springerlink.com/content/h9wrn7p72x26q035/ @@ -2287,25 +2271,25 @@ OMIM mapping confirmed by DO. [SN]. - DOID:12757 - ICD10CM:C69.1 - ICD9CM:190.4 - NCI:C3565 - NCI:C4361 - SNOMEDCT_US_2023_03_01:126997008 - SNOMEDCT_US_2023_03_01:93766000 - UMLS_CUI:C0153629 - UMLS_CUI:C0339304 + DOID:12757 + ICD10CM:C69.1 + ICD9CM:190.4 + NCI:C3565 + NCI:C4361 + SNOMEDCT_US_2021_09_01:126997008 + SNOMEDCT_US_2021_09_01:93766000 + UMLS_CUI:C0153629 + UMLS_CUI:C0339304 Corneal tumor malignant Corneal tumor malignant neoplasm of cornea malignant tumor of cornea neoplasm of cornea - disease_ontology - DOID:6199 + disease_ontology + DOID:6199 - cornea cancer + cornea cancer @@ -2314,24 +2298,24 @@ OMIM mapping confirmed by DO. [SN]. - A disease that has_material_basis_in genetic variations in the human genome. - MESH:D030342 - NCI:C3101 - SNOMEDCT_US_2023_03_01:32895009 - UMLS_CUI:C0019247 - disease_ontology - DOID:630 + A disease that has_material_basis_in genetic variations in the human genome. + MESH:D030342 + NCI:C3101 + SNOMEDCT_US_2021_09_01:32895009 + UMLS_CUI:C0019247 + disease_ontology + DOID:630 - genetic disease + genetic disease - A disease that has_material_basis_in genetic variations in the human genome. + A disease that has_material_basis_in genetic variations in the human genome. - url:http://ghr.nlm.nih.gov/ + url:http://ghr.nlm.nih.gov/ @@ -2340,33 +2324,33 @@ OMIM mapping confirmed by DO. [SN]. - A cell type benign neoplasm that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures. - DOID:2655 - ICDO:8140/0 - MESH:D000236 - NCI:C2855 - NCI:C4196 - SNOMEDCT_US_2023_03_01:443416007 - SNOMEDCT_US_2023_03_01:79041005 - UMLS_CUI:C0001430 - UMLS_CUI:C0334389 + A cell type benign neoplasm that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures. + DOID:2655 + ICDO:8140/0 + MESH:D000236 + NCI:C2855 + NCI:C4196 + SNOMEDCT_US_2021_09_01:443416007 + SNOMEDCT_US_2021_09_01:79041005 + UMLS_CUI:C0001430 + UMLS_CUI:C0334389 acinar cell adenoma acinic cell adenoma adenomas - disease_ontology - DOID:657 + disease_ontology + DOID:657 - adenoma - MESH:D000236 + adenoma + MESH:D000236 - A cell type benign neoplasm that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures. + A cell type benign neoplasm that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures. - url:http://coloncancer.about.com/od/glossaries/g/Adenoma.htm - url:http://en.wikipedia.org/wiki/Adenoma + url:http://coloncancer.about.com/od/glossaries/g/Adenoma.htm + url:http://en.wikipedia.org/wiki/Adenoma @@ -2375,24 +2359,24 @@ OMIM mapping confirmed by DO. [SN]. - A disease that manifests in a defined anatomical structure. - DOID:1 - DOID:2 - DOID:5 - DOID:71 - DOID:72 - DOID:8 - disease_ontology - DOID:7 + A disease that manifests in a defined anatomical structure. + DOID:1 + DOID:2 + DOID:5 + DOID:71 + DOID:72 + DOID:8 + disease_ontology + DOID:7 - disease of anatomical entity + disease of anatomical entity - A disease that manifests in a defined anatomical structure. + A disease that manifests in a defined anatomical structure. - url:http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=anatomic + url:http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=anatomic @@ -2401,31 +2385,33 @@ OMIM mapping confirmed by DO. [SN]. - An immune system disease that is located_in the lymphatic system. - MESH:D008206 - SNOMEDCT_US_2023_03_01:266326002 - UMLS_CUI:C0024228 + An immune system disease that is located_in the lymphatic system. + MESH:D008206 + SNOMEDCT_US_2021_09_01:266326002 + UMLS_CUI:C0024228 + Adenopathy Lymphangiopathy Lymphatic disease + Lymphatic disorder disease of lympoid system disorder of lymph node and lymphatics disorder of lymphatic system disorder of lymphoid system lymphatic disorder lympoid system disease - disease_ontology - DOID:75 + disease_ontology + DOID:75 - lymphatic system disease + lymphatic system disease - An immune system disease that is located_in the lymphatic system. + An immune system disease that is located_in the lymphatic system. - url:http://en.wikipedia.org/wiki/Lymphatic_disease - url:http://www.nlm.nih.gov/medlineplus/lymphaticdiseases.html + url:http://en.wikipedia.org/wiki/Lymphatic_disease + url:http://www.nlm.nih.gov/medlineplus/lymphaticdiseases.html @@ -2434,22 +2420,22 @@ OMIM mapping confirmed by DO. [SN]. - A leukemia that occurs in children. - NCI:C4989 - UMLS_CUI:C1332977 - disease_ontology - DOID:7757 + A leukemia that occurs in children. + NCI:C4989 + UMLS_CUI:C1332977 + disease_ontology + DOID:7757 - childhood leukemia + childhood leukemia - A leukemia that occurs in children. + A leukemia that occurs in children. - url:http://www.nlm.nih.gov/medlineplus/leukemiachildhood.html + url:http://www.nlm.nih.gov/medlineplus/leukemiachildhood.html @@ -2458,28 +2444,28 @@ OMIM mapping confirmed by DO. [SN]. - A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision. - ICD10CM:H26 - ICD9CM:366.8 - OMIM:601371 - OMIM:PS116200 - SNOMEDCT_US_2023_03_01:193620000 - UMLS_CUI:C0029531 - disease_ontology - DOID:83 + A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision. + ICD10CM:H26 + ICD9CM:366.8 + OMIM:601371 + OMIM:PS116200 + SNOMEDCT_US_2021_09_01:193620000 + UMLS_CUI:C0029531 + disease_ontology + DOID:83 - Xref MGI. - cataract - MESH:D002386 + Xref MGI. + cataract + MESH:D002386 - A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision. + A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision. - url:http://en.wikipedia.org/wiki/Cataract - url:https://www.ncbi.nlm.nih.gov/pubmed/10414631 + url:http://en.wikipedia.org/wiki/Cataract + url:https://www.ncbi.nlm.nih.gov/pubmed/10414631 @@ -2488,31 +2474,31 @@ OMIM mapping confirmed by DO. [SN]. - A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. - DOID:11894 - DOID:11895 - DOID:29 - DOID:766 - ICD10CM:J98.4 - MESH:D008171 - NCI:C3198 - SNOMEDCT_US_2023_03_01:266374002 - UMLS_CUI:C0024115 - disease_ontology - DOID:850 + A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. + DOID:11894 + DOID:11895 + DOID:29 + DOID:766 + ICD10CM:J98.4 + MESH:D008171 + NCI:C3198 + SNOMEDCT_US_2021_09_01:266374002 + UMLS_CUI:C0024115 + disease_ontology + DOID:850 - Updating out dated CUI and removing lung abscess as a synonym. - lung disease + Updating out dated CUI and removing lung abscess as a synonym. + lung disease - A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. + A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. - url:http://www.niehs.nih.gov/health/topics/conditions/lung-disease/index.cfm - url:http://www.nlm.nih.gov/medlineplus/ency/article/000066.htm + url:http://www.niehs.nih.gov/health/topics/conditions/lung-disease/index.cfm + url:http://www.nlm.nih.gov/medlineplus/ency/article/000066.htm @@ -2521,18 +2507,18 @@ OMIM mapping confirmed by DO. [SN]. - A myeloid leukemia that is characterized by over production of white blood cells. - DOID:8551 - DOID:8606 - EFO:0000339 - GARD:6105 - ICD9CM:205.1 - ICDO:9863/3 - KEGG:05220 - OMIM:608232 - ORDO:521 - SNOMEDCT_US_2023_03_01:154592009 - UMLS_CUI:C0023473 + A myeloid leukemia that is characterized by over production of white blood cells. + DOID:8551 + DOID:8606 + EFO:0000339 + GARD:6105 + ICD9CM:205.1 + ICDO:9863/3 + KEGG:05220 + OMIM:608232 + ORDO:521 + SNOMEDCT_US_2021_09_01:154592009 + UMLS_CUI:C0023473 CML CML - chronic Myelogenous Leukemia Myeloid Leukemia, chronic @@ -2541,22 +2527,21 @@ OMIM mapping confirmed by DO. [SN]. chronic myelogenous leukaemia chronic myelogenous leukemia chronic myeloid leukaemia - disease_ontology - DOID:8552 + disease_ontology + DOID:8552 - - OMIM mapping confirmed by DO. [SN]. - chronic myeloid leukemia + OMIM mapping confirmed by DO. [SN]. + chronic myeloid leukemia - A myeloid leukemia that is characterized by over production of white blood cells. + A myeloid leukemia that is characterized by over production of white blood cells. - url:http://www.cancer.gov/dictionary?CdrID=46755 + url:http://www.cancer.gov/dictionary?CdrID=46755 @@ -2565,39 +2550,38 @@ OMIM mapping confirmed by DO. [SN]. - A leukemia that is located_in myeloid tissue. - DOID:8878 - DOID:8879 - DOID:8910 - DOID:9066 - DOID:9126 - GARD:8226 - ICD10CM:C92 - ICD9CM:205 - ICDO:9860/3 - MESH:D007951 - NCI:C3172 - SNOMEDCT_US_2023_03_01:269631008 - UMLS_CUI:C0023470 + A leukemia that is located_in myeloid tissue. + DOID:8878 + DOID:8879 + DOID:8910 + DOID:9066 + DOID:9126 + GARD:8226 + ICD10CM:C92 + ICD9CM:205 + ICDO:9860/3 + MESH:D007951 + NCI:C3172 + SNOMEDCT_US_2021_09_01:269631008 + UMLS_CUI:C0023470 Non-Lymphocytic Leukemia leukaemia myelogenous leukemia myelogenous myeloid granulocytic leukaemia myeloid granulocytic leukemia myeloid leukaemia - disease_ontology - DOID:8692 + disease_ontology + DOID:8692 - - myeloid leukemia + myeloid leukemia - A leukemia that is located_in myeloid tissue. + A leukemia that is located_in myeloid tissue. - url:http://en.wikipedia.org/wiki/Myeloid_leukemia + url:http://en.wikipedia.org/wiki/Myeloid_leukemia @@ -2606,27 +2590,27 @@ OMIM mapping confirmed by DO. [SN]. - A carcinoma that is an early development defined by the absence of invasion of surrounding tissues. - DOID:8793 - DOID:8821 - ICD10CM:D09.9 - ICD9CM:230-234.99 - MESH:D002278 - NCI:C2917 - SNOMEDCT_US_2023_03_01:189208007 - UMLS_CUI:C0007099 - disease_ontology - DOID:8719 + A carcinoma that is an early development defined by the absence of invasion of surrounding tissues. + DOID:8793 + DOID:8821 + ICD10CM:D09.9 + ICD9CM:230-234.99 + MESH:D002278 + NCI:C2917 + SNOMEDCT_US_2021_09_01:109355002 + UMLS_CUI:C0007099 + disease_ontology + DOID:8719 - in situ carcinoma + in situ carcinoma - A carcinoma that is an early development defined by the absence of invasion of surrounding tissues. + A carcinoma that is an early development defined by the absence of invasion of surrounding tissues. - url:http://en.wikipedia.org/wiki/Carcinoma_in_situ + url:http://en.wikipedia.org/wiki/Carcinoma_in_situ @@ -2635,32 +2619,31 @@ OMIM mapping confirmed by DO. [SN]. - An acute myeloid leukemia that derives from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers. - DOID:9009 - GARD:524 - ICD10CM:C94.2 - ICD9CM:207.2 + An acute myeloid leukemia that derives from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers. + DOID:9009 + GARD:524 + ICD10CM:C94.2 + ICD9CM:207.2 ICDO:9910/3 - MESH:D007947 - NCI:C3170 - SNOMEDCT_US_2023_03_01:52220008 - UMLS_CUI:C0023462 + MESH:D007947 + NCI:C3170 + SNOMEDCT_US_2021_09_01:52220008 + UMLS_CUI:C0023462 Megakaryocytic myelosis Thrombocytic leukaemia - disease_ontology - DOID:8761 + disease_ontology + DOID:8761 - - acute megakaryocytic leukemia + acute megakaryocytic leukemia - An acute myeloid leukemia that derives from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers. - url:https://en.wikipedia.org/wiki/Acute_megakaryoblastic_leukemia - url:https://pubmed.ncbi.nlm.nih.gov/26228843/ - url:https://www.orpha.net/data/patho/GB/uk-AMLM7.pdf + An acute myeloid leukemia that derives from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers. + url:https://en.wikipedia.org/wiki/Acute_megakaryoblastic_leukemia + url:https://pubmed.ncbi.nlm.nih.gov/26228843/ + url:https://www.orpha.net/data/patho/GB/uk-AMLM7.pdf @@ -2669,19 +2652,19 @@ OMIM mapping confirmed by DO. [SN]. - A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. - DOID:9118 - DOID:9171 - GARD:12757 - ICD10CM:C92.0 - ICD9CM:205.0 - ICDO:9861/3 - KEGG:05221 - MESH:D015470 - NCI:C3171 - OMIM:601626 - SNOMEDCT_US_2023_03_01:17788007 - UMLS_CUI:C0023467 + A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. + DOID:9118 + DOID:9171 + GARD:12757 + ICD10CM:C92.0 + ICD9CM:205.0 + ICDO:9861/3 + KEGG:05221 + MESH:D015470 + NCI:C3171 + OMIM:601626 + SNOMEDCT_US_2021_09_01:91861009 + UMLS_CUI:C0023467 AML - acute Myeloid Leukemia Leukemia, Myelocytic, acute acute myeloblastic leukaemia @@ -2689,27 +2672,26 @@ OMIM mapping confirmed by DO. [SN]. acute myelogenous leukaemia acute myelogenous leukemia acute myeloid leukaemia - disease_ontology - DOID:9119 + disease_ontology + DOID:9119 - - OMIM mapping confirmed by DO. [SN]. - acute myeloid leukemia + OMIM mapping confirmed by DO. [SN]. + acute myeloid leukemia - A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. + A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. - url:http://cancergenome.nih.gov/cancersselected/acutemyeloidleukemia - url:http://en.wikipedia.org/wiki/Acute_myeloid_leukemia - url:http://www.cancer.gov/dictionary?cdrid=44363 - url:https://www.cancer.org/cancer/acute-myeloid-leukemia/detection-diagnosis-staging/how-classified.html + url:http://cancergenome.nih.gov/cancersselected/acutemyeloidleukemia + url:http://en.wikipedia.org/wiki/Acute_myeloid_leukemia + url:http://www.cancer.gov/dictionary?cdrid=44363 + url:https://www.cancer.org/cancer/acute-myeloid-leukemia/detection-diagnosis-staging/how-classified.html @@ -2718,34 +2700,34 @@ OMIM mapping confirmed by DO. [SN]. - A large intestine cancer that is located_in the colon and/or located_in the rectum. - ICD10CM:C18.9 - KEGG:05210 - MESH:D015179 - NCI:C2956 - NCI:C4978 - OMIM:114500 - SNOMEDCT_US_2023_03_01:126837005 - SNOMEDCT_US_2023_03_01:93854002 - UMLS_CUI:C0009404 - UMLS_CUI:C0346629 - disease_ontology - DOID:9256 + A large intestine cancer that is located_in the colon and/or located_in the rectum. + ICD10CM:C18.9 + KEGG:05210 + MESH:D015179 + NCI:C2956 + NCI:C4978 + OMIM:114500 + SNOMEDCT_US_2021_09_01:126837005 + SNOMEDCT_US_2021_09_01:93854002 + UMLS_CUI:C0009404 + UMLS_CUI:C0346629 + disease_ontology + DOID:9256 - Xref MGI. + Xref MGI. OMIM mapping confirmed by DO. [SN]. - colorectal cancer + colorectal cancer - A large intestine cancer that is located_in the colon and/or located_in the rectum. + A large intestine cancer that is located_in the colon and/or located_in the rectum. - url:http://www.cancer.gov/dictionary?CdrID=444983 + url:http://www.cancer.gov/dictionary?CdrID=444983 @@ -2754,23 +2736,23 @@ OMIM mapping confirmed by DO. [SN]. - A mouth disease that is characterized by inflammation of the mouth and lips. - ICD10CM:K12.1 - MESH:D013280 - NCI:C26887 - SNOMEDCT_US_2023_03_01:95361005 - UMLS_CUI:C0038362 - disease_ontology - DOID:9637 + A mouth disease that is characterized by inflammation of the mouth and lips. + ICD10CM:K12.1 + MESH:D013280 + NCI:C26887 + SNOMEDCT_US_2021_09_01:95361005 + UMLS_CUI:C0038362 + disease_ontology + DOID:9637 - stomatitis + stomatitis - A mouth disease that is characterized by inflammation of the mouth and lips. - url:https://en.wikipedia.org/wiki/Stomatitis + A mouth disease that is characterized by inflammation of the mouth and lips. + url:https://en.wikipedia.org/wiki/Stomatitis @@ -2779,40 +2761,40 @@ OMIM mapping confirmed by DO. [SN]. - A acute leukemia that is characterized by over production of lymphoblasts. - DOID:5600 - EFO:0000220 - GARD:522 - ICD10CM:C91.00 - ICD9CM:204.0 - NCI:C3167 - NCI:C7055 - OMIM:247640 - OMIM:613065 - ORDO:513 - SNOMEDCT_US_2023_03_01:128822004 - UMLS_CUI:C0023449 - UMLS_CUI:C1335469 - ALL + A acute leukemia that is characterized by over production of lymphoblasts. + DOID:5600 + EFO:0000220 + GARD:522 + ICD10CM:C91.00 + ICD9CM:204.0 + NCI:C3167 + NCI:C7055 + OMIM:247640 + OMIM:613065 + ORDO:513 + SNOMEDCT_US_2021_09_01:128822004 + UMLS_CUI:C0023449 + UMLS_CUI:C1335469 + ALL acute lymphoblastic leukaemia acute lymphocytic leukaemia - precursor lymphoblastic lymphoma/leukemia - disease_ontology - DOID:9952 + precursor lymphoblastic lymphoma/leukemia + disease_ontology + DOID:9952 - Xref MGI. - acute lymphoblastic leukemia + Xref MGI. + acute lymphoblastic leukemia - A acute leukemia that is characterized by over production of lymphoblasts. + A acute leukemia that is characterized by over production of lymphoblasts. - url:http://www.cancer.gov/dictionary?CdrID=46332 + url:http://www.cancer.gov/dictionary?CdrID=46332 diff --git a/src/ontology/imports/efo_import.owl b/src/ontology/imports/efo_import.owl index b7f1c45..cd5080a 100644 --- a/src/ontology/imports/efo_import.owl +++ b/src/ontology/imports/efo_import.owl @@ -10,14 +10,13 @@ xmlns:xml="http://www.w3.org/XML/1998/namespace" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" - xmlns:chebi="http://purl.obolibrary.org/obo/chebi#3" xmlns:terms="http://purl.org/dc/terms/" xmlns:ubprop="http://purl.obolibrary.org/obo/ubprop#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#" xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#"> - - 2023-12-18 + + 2022-10-05 @@ -93,12 +92,6 @@ - - - - - - @@ -155,14 +148,6 @@ - - - - - - - - @@ -179,9 +164,9 @@ - + - + @@ -195,17 +180,9 @@ - - - - - - - - - + - + @@ -219,14 +196,6 @@ - - - - - - - - @@ -259,9 +228,9 @@ - + - + @@ -300,6 +269,12 @@ + + + + + + @@ -350,6 +325,12 @@ + + + + + + @@ -471,19 +452,32 @@ + is part of is part of + my brain is part of my body (continuant parthood, two material entities) my brain is part of my body (continuant parthood, two material entities) + my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity) my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity) + this day is part of this year (occurrent parthood) this day is part of this year (occurrent parthood) For continuants: C part_of C' if and only if: given any c that instantiates C at a time t, there is some c' such that c' instantiates C' at time t, and c *part_of* c' at t. For processes: P part_of P' if and only if: given any p that instantiates P at a time t, there is some p' such that p' instantiates P' at time t, and p *part_of* p' at t. (Here *part_of* is the instance-level part-relation.) + a core relation that holds between a part and its whole a core relation that holds between a part and its whole + Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. + Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime + Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) + +A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'. Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'. + part_of part_of + + @@ -494,9 +488,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An http://www.ebi.ac.uk/efo/part_of BFO:0000050 + OBO_REL:part_of part of external + human_stages_ontology + plant_ontology + protein quality + relationship spatial uberon part_of @@ -512,7 +511,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An http://www.obofoundry.org/ro/#OBO_REL:part_of - https://wiki.geneontology.org/Part_of @@ -609,6 +607,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + + inheres in this fragility inheres in this vase this fragility is a characteristic of this vase @@ -621,11 +621,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An http://www.ebi.ac.uk/efo/EFO_0000829 RO:0000052 + fly_anatomy.ontology + characteristic_of inheres_in characteristic_of inheres_in Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing. characteristic of + characteristic_of inheres in inheres in inheres_in @@ -822,19 +825,16 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. - chemical entity - chebi_ontology - CHEBI:24431 - + A drug, solvent, chemical, etc., with a property that can be measured such as concentration. + A molecular entity consisting of two or more chemical elements. + James Malone + Tomasz Adamusiak + true + chemical compound + heteroatomic molecular entities + heteroatomic molecular entity chemical entity - - - - chemical entity - UniProt - @@ -843,18 +843,9 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A role played by the molecular entity or part thereof within a biological context. - chebi_ontology - biological function - CHEBI:24432 - + Helen Parkinson biological role - - - - biological function - ChEBI - @@ -862,97 +853,18 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - A chemical entity constituting the smallest component of an element having the chemical properties of the element. - CHEBI:22671 - CHEBI:23907 MeSH:D004602 NCIt:C1940 NCIt:C48792 SNOMEDCT:290004009 atom - chebi_ontology - atome - atomo - atoms - atomus - element - elements - CHEBI:33250 - - atom + atome + atomo + atoms + atomus + elements + element - - - - atoms - ChEBI - - - - - atomus - ChEBI - - - - - element - ChEBI - - - - - elements - ChEBI - - - - - atom - IUPAC - - - - - - atome - IUPAC - - - - - atomo - IUPAC - - - - - - - - - - A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome. - CHEBI:13677 - CHEBI:14911 - MO:683 - MeSH:D011506 - NCIt:C17021 - PRO:000000001 - SNOMEDCT:88878007 - proteins - chebi_ontology - CHEBI:36080 - - protein - - - - - proteins - IUPAC - - @@ -971,10 +883,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + The role of a chemical to be an anti-inflammatory drug. A role played by the molecular entity or part thereof within a chemical context. - chebi_ontology - CHEBI:51086 - + James Malone + http://www.ebi.ac.uk/efo/EFO_0001815 + http://purl.org/obo/owl/CHEBI#CHEBI_51086 chemical role @@ -1030,114 +943,31 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). - https://github.com/geneontology/go-ontology/issues/17729 + +The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. + + The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. + GO:0008372 NIF_Subcellular:sao1337158144 - cell or subcellular entity cellular component + cellular_component + cellular component unknown cellular_component - subcellular entity GO:0005575 + - + - Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. - cellular_component - - - - - A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). - GOC:pdt - - - - - subcellular entity - NIF_Subcellular:nlx_subcell_100315 - - - - - - - - - A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. - https://github.com/geneontology/go-ontology/issues/17776 - NCIt:C28217 - SNOMEDCT:83167003 - Wikipedia:Intracellular - internal to cell - intracellular - protoplasm - cellular_component - nucleocytoplasm - protoplast - GO:0005622 - - - - - intracellular anatomical structure - - - - - A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. - ISBN:0198506732 - - - - - nucleocytoplasm - GOC:mah - - - - - protoplast - GOC:mah - - - - - - - - - - - - - - - The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. - https://github.com/geneontology/go-ontology/issues/23023 - MeSH:D003593 - NCIt:C13226 - Wikipedia:Cytoplasm - cellular_component - GO:0005737 - - - - - - - - cytoplasm + + +Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. + + cellular component - - - - The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. - ISBN:0198547684 - @@ -1145,87 +975,48 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. - https://github.com/geneontology/go-ontology/issues/24968 - jl - 2012-09-19T15:05:24Z + Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. + + The activities of living organisms that support life in single- or multi-cellular organisms from their origin through the progression of life. + GO:0000004 GO:0007582 - GO:0044699 GO:0008150 MeSH:D055705 NCIt:C17828 Wikipedia:Biological_process + Physiological Processes biological process + biological_process physiological process + biological process unknown biological_process - single organism process - single-organism process GO:0008150 + - + - Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. - biological_process + + Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. + + biological process - - - - A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. - GOC:pdt - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. true GO:0009314 - response to electromagnetic radiation stimulus - response to radiation stimulus - biological_process - GO:0009314 - Note that 'radiation' refers to electromagnetic radiation of any wavelength. response to radiation - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. - GOC:jl - Wikipedia:Electromagnetic_radiation - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. - https://github.com/geneontology/go-ontology/issues/16572 - response to abiotic stress - biological_process - GO:0009628 - - - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - response to abiotic stimulus - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. - GOC:hb - @@ -1233,31 +1024,99 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - jl - 2012-12-11T16:56:55Z + +Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + + GO:0008151 - GO:0044763 GO:0050875 NCIt:C20480 cell physiology cellular physiological process cell growth and/or maintenance biological_process - single-organism cellular process GO:0009987 - + - This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. + cellular process - - - - Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GOC:go_curators - GOC:isa_complete - + + + + + + + + + + + + + + + + + + + + + + + + + +Any constituent part of a cell, the basic structural and functional unit of all organisms. + + + NCIt:C34070 + cellular_component + protoplast + GO:0044464 + + + + +Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + + cell part + + + + + + + + + +A biological process that involves only one organism. + + + janelomax + 2012-09-19T15:05:24Z + single organism process + biological_process + GO:0044699 + single-organism process + + + + + + + + + + +Any process that is carried out at the cellular level, occurring within a single organism. + + + janelomax + 2012-12-11T16:56:55Z + biological_process + GO:0044763 + single-organism cellular process + @@ -1265,51 +1124,47 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. + +Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. + + Helen Parkinson + GO:0051869 GO:0050896 SNOMEDCT:248237001 physiological response to stimulus + response to treatment biological_process GO:0050896 - - - - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + + +Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + response to stimulus - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. - GOC:ai - GOC:bf - - + - Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. + +Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. + + biological_process GO:0051716 - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + + +Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + cellular response to stimulus - - - - Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. - GOC:bf - GOC:jl - @@ -1639,25 +1494,6 @@ This issue is outside the scope of OBI. - - - - - A quality which inheres in an process. - PATO:0001239 - PATO:0001240 - quality of a process - quality of occurrent - quality of process - relational quality of occurrent - quality - PATO:0001236 - See comments of relational quality of a physical entity. - process quality - - - - @@ -1668,19 +1504,6 @@ This issue is outside the scope of OBI. - - - - - A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions. - SO editors - NCIt:C16612 - SNOMEDCT:67271001 - gene - - - - @@ -1736,18 +1559,6 @@ This issue is outside the scope of OBI. - - - - - Jon Ison - http://www.ebi.ac.uk/efo/EFO_0004377 - microeinstein per second and square meter - microeinstein per square meter per second - - - - @@ -1926,16 +1737,6 @@ Dorso-ventral vaginal septa is observed in some BALB/cJ females, and may contrib - - - - - Anatomical structure which has as its parts one or more ordered aggregates of nucleotide, amino acid fatty acid or sugar molecules bonded to one another. - biological macromolecule - - - - @@ -1943,7 +1744,6 @@ Dorso-ventral vaginal septa is observed in some BALB/cJ females, and may contrib The original group of Swiss mice that served as progenitors of this stock consisted of two male and seven female albino mice derived from a non-inbred stock in the laboratory of Dr. de Coulon, Centre Anticancereux Romand, Lausanne, Switzerland. http://www.criver.com/en-US/ProdServ/ByType/ResModOver/ResMod/Pages/CD-1Mouse.aspx CD-1 mus - Crl:CD1(ICR) CD1 mus strain @@ -1952,13 +1752,12 @@ Dorso-ventral vaginal septa is observed in some BALB/cJ females, and may contrib - + Inbred Strain TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: d Generation: F219p (14-DEC-06) Appearance: dilute brown Related Genotype: a/a Tyrp1b/Tyrp1b Myo5ad/Myo5ad Important Note This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss that is already severe by 3 months of age. Strain Description DBA/2J is a widely used inbred strain that is valuable in a wide number of research areas including cardiovascular biology, neurobiology, and sensorineural research. James Malone Beck, J.A., et al., Genealogies of mouse inbred strains (2000), Nature, Jan2000, v24, p23 D2 D2J - DBA/2 DBA2 DBA/2J @@ -2045,7 +1844,6 @@ Wild-derived mice are genetically distinct from common laboratory mice for a num Watkins Star Line B (WSB) was derived from wild mice trapped in Eastern Shore, Maryland. WSB is characterized by a distinct and consistent white head blaze, variable ventral spotting and a slight coat dilution on the agouti background. The variation in pigment is the result of the spontaneous mutation blaze (Kitlblz).Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research. Sirarat Sarntivijai https://www.jax.org/strain/001145 - WSB WSB/EiJ @@ -2086,7 +1884,7 @@ Wild-derived mice are genetically distinct from common laboratory mice for a num - + CBA/J inbred mice are widely used as a general purpose strain. CBA/J strain is the only CBA substrain that carries the Pde6brd1 mutation, which causes blindness by wean age. CBA/J mice are not histocompatible with the CBA/CaJ (Stock No. 000654) substrain (Green and Kaufer, 1965). The CBA/J inbred mouse strain is used to study granulomatous experimental autoimmune thyroiditis (G-EAT), are relatively resistant to diet-induced atherosclerosis (Paigen et al. 1990), and develop a mild hearing loss late in life, with most of the hearing loss occurring in the higher frequencies (Sweet et al. 1988). Renal tubulointerstitial lesions have been observed in this strain at a high frequency (Rudofsky 1978). Some CBA/J mice spontaneously develop exocrine pancreatic insufficiency syndrome (Eppig and Leiter 1977, Leiter et al. 1977). @@ -2142,37 +1940,6 @@ The CBA/J inbred mouse strain is used to study granulomatous experimental autoim C57BL/6JxCAST/EiJ - - - - - - - - Inbred Strain. - Zoe May Pendlington - 2023-11-02T09:06:58Z - MGI:2159849 - TGEMO:00019 - DBA - - - - - - - - - Strain family. - Zoe May Pendlington - 2023-11-02T09:09:47Z - MGI:2159850 - TGEMO:00108 - C - CB - XXXIX - CBA - diff --git a/src/ontology/imports/envo_import.owl b/src/ontology/imports/envo_import.owl index 2de1fe1..e403f30 100644 --- a/src/ontology/imports/envo_import.owl +++ b/src/ontology/imports/envo_import.owl @@ -9,18 +9,15 @@ xmlns:xml="http://www.w3.org/XML/1998/namespace" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" xmlns:envo="http://purl.obolibrary.org/obo/envo#" + xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" - xmlns:skos="http://www.w3.org/2004/02/skos/core#" - xmlns:swrl="http://www.w3.org/2003/11/swrl#" - xmlns:swrla="http://swrl.stanford.edu/ontologies/3.3/swrla.owl#" - xmlns:swrlb="http://www.w3.org/2003/11/swrlb#" xmlns:terms="http://purl.org/dc/terms/" xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#" xmlns:taxslim="http://purl.obolibrary.org/obo/ncbitaxon/subsets/taxslim#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - 2023-12-18 + + 2022-10-05 @@ -68,9 +65,7 @@ - - editor note - + @@ -142,48 +137,6 @@ - - - - - - - - - - - - - - - - If R <- P o Q is a defining property chain axiom, then it also holds that R -> P o Q. Note that this cannot be expressed directly in OWL - is a defining property chain axiom - - - - - - - - If R <- P o Q is a defining property chain axiom, then (1) R -> P o Q holds and (2) Q is either reflexive or locally reflexive. A corollary of this is that P SubPropertyOf R. - is a defining property chain axiom where second argument is reflexive - - - - - - - - - - - - - - - - @@ -376,12 +329,6 @@ - - - - - - @@ -400,12 +347,6 @@ - - - - - - @@ -490,27 +431,21 @@ - - - - - - - + - + - + - + - + - + @@ -537,7 +472,7 @@ this day is part of this year (occurrent parthood) a core relation that holds between a part and its whole Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. - Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ + Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'. @@ -573,7 +508,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An this year has part this day (occurrent parthood) a core relation that holds between a whole and its part Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part. - Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ + Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'. @@ -590,9 +525,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - realized in this disease is realized in this disease course this fragility is realized in this shattering @@ -610,8 +542,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - realizes this disease course realizes this disease this investigation realizes this investigator role @@ -628,14 +558,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - - - - - preceded by x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. @@ -652,13 +574,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - - - - precedes x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. @@ -670,17 +585,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - - - - - - - - occurs in b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t occurs_in @@ -719,15 +623,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - A relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist through the separation or transformation of a part of the old entity, and the new entity inherits a significant portion of the matter belonging to that part of the old entity. - derives from part of - - - - @@ -743,7 +638,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. A relation between a process and a disposition such that the existence of the disposition is caused by the execution of the process. Consider ceding to RO - + cjm 2018-11-03T20:58:13Z generates @@ -754,16 +649,14 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - inheres in - this fragility is a characteristic of this vase - this red color is a characteristic of this apple - a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence. + this fragility inheres in this vase + this red color inheres in this apple + a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence + A dependent inheres in its bearer at all times for which the dependent exists. inheres_in - Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing. - characteristic of + inheres in @@ -771,17 +664,15 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - bearer of this apple is bearer of this red color this vase is bearer of this fragility - Inverse of characteristic_of + a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist. bearer_of is bearer of - has characteristic + bearer of @@ -789,9 +680,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - participates in this blood clot participates in this blood coagulation this input material (or this output material) participates in this process @@ -806,17 +694,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - - - - - - - - has participant this blood coagulation has participant this blood clot this investigation has participant this investigator @@ -830,75 +707,10 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - - - - this catalysis function is a function of this enzyme - a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence - A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists. - function_of - is function of - This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. - function of - - - - - - - - - - this red color is a quality of this apple - a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence - A quality inheres in its bearer at all times for which the quality exists. - is quality of - quality_of - This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. - quality of - - - - - - - - - - this investigator role is a role of this person - a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence - A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists. - is role of - role_of - This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. - role of - - - - - - - - - - - this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function) - a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence - A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists. - has_function - has function - - - - - this apple has quality this red color a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist. @@ -912,8 +724,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - this person has role this investigator role (more colloquially: this person has this role of investigator) a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists. @@ -923,36 +733,9 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - - - - - a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence - has disposition - - - - - - - - - inverse of has disposition - - This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. - disposition of - - - - - - this cell derives from this parent cell (cell division) this nucleus derives from this parent nucleus (nuclear division) @@ -966,128 +749,21 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - this parent cell derives into this cell (cell division) - this parent nucleus derives into this nucleus (nuclear division) - - a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity - This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops into'. To avoid making statements about a future that may not come to pass, it is often better to use the backward-looking 'derives from' rather than the forward-looking 'derives into'. - derives_into - - derives into - - - - - - - - - - is location of - my head is the location of my brain - this cage is the location of this rat - a relation between two independent continuants, the location and the target, in which the target is entirely within the location - Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ - location_of - - location of - - - - - - - - - - - - - - - contained in - Containment is location not involving parthood, and arises only where some immaterial continuant is involved. - Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation. If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition): - Intended meaning: -domain: material entity -range: spatial region or site (immaterial continuant) - - contained_in - - - contained in - - - - - - - - contains - - - contains - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - located in my brain is located in my head this rat is located in this cage a relation between two independent continuants, the target and the location, in which the target is entirely within the location Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus - Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ + Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime located_in http://www.obofoundry.org/ro/#OBO_REL:located_in located in - - - - - This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation. - - - - - - This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation. - @@ -1095,18 +771,6 @@ range: spatial region or site (immaterial continuant) - - - - - - - - - - - - X outer_layer_of Y iff: . X :continuant that bearer_of some PATO:laminar . X part_of Y @@ -1124,155 +788,10 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - - - - - - A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B. - dos - 2017-05-24T09:30:46Z - has regulatory component activity - - - - - - - - - - A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B. - dos - 2017-05-24T09:31:01Z - By convention GO molecular functions are classified by their effector function. Internal regulatory functions are treated as components. For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'. - has negative regulatory component activity - - - - - - - - - - A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B. - dos - 2017-05-24T09:31:17Z - By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'. - has positive regulatory component activity - - - - - - - - - dos - 2017-05-24T09:44:33Z - A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B. - has component activity - - - - - - - - - - - w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. - dos - 2017-05-24T09:49:21Z - has component process - - - - - - - - - - dos - 2017-09-17T13:52:24Z - Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. - directly regulated by - - - - - Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. - GOC:dos - - - - - - - - - - Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1. - dos - 2017-09-17T13:52:38Z - directly negatively regulated by - - - - - Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1. - GOC:dos - - - - - - - - - - Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1. - dos - 2017-09-17T13:52:47Z - directly positively regulated by - - - - - Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1. - GOC:dos - - - - - - - - - - A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity. - dos - 2017-09-22T14:14:36Z - This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations. - has effector activity - - - - - A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity. - GOC:dos - - - - - David Osumi-Sutherland Previously had ID http://purl.obolibrary.org/obo/RO_0002122 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point. No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line. Official ID now chosen from DOS ID range. @@ -1285,11 +804,6 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - - - - - David Osumi-Sutherland X ends_after Y iff: end(Y) before_or_simultaneous_with end(X) @@ -1298,116 +812,48 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - + - - - - David Osumi-Sutherland - starts_at_end_of - X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) - immediately preceded by + + + + x overlaps y if and only if there exists some z such that x has part z and z part of y + http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y) + + + + + overlaps - + - - - David Osumi-Sutherland - ends_at_start_of - meets - - - X immediately_precedes_Y iff: end(X) simultaneous_with start(Y) - immediately precedes - + - + - - - David Osumi-Sutherland - o - overlaps + + + + A is spatially_disjoint_from B if and only if they have no parts in common + There are two ways to encode this as a shortcut relation. The other possibility to use an annotation assertion between two classes, and expand this to a disjointness axiom. + Chris Mungall + + Note that it would be possible to use the relation to label the relationship between a near infinite number of structures - between the rings of saturn and my left earlobe. The intent is that this is used for parsiomoniously for disambiguation purposes - for example, between siblings in a jointly exhaustive pairwise disjointness hierarchy + BFO_0000051 exactly 0 (BFO_0000050 some ?Y) + - X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y). - ends during + spatially disjoint from + https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern - - - - - - - - - - - - - - - - - - - - - - - x overlaps y if and only if there exists some z such that x has part z and z part of y - http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y) - - - - - overlaps - - - - - - - - - true - - - - - - - - - - - - - - - - A is spatially_disjoint_from B if and only if they have no parts in common - There are two ways to encode this as a shortcut relation. The other possibility to use an annotation assertion between two classes, and expand this to a disjointness axiom. - Chris Mungall - - Note that it would be possible to use the relation to label the relationship between a near infinite number of structures - between the rings of saturn and my left earlobe. The intent is that this is used for parsiomoniously for disambiguation purposes - for example, between siblings in a jointly exhaustive pairwise disjointness hierarchy - BFO_0000051 exactly 0 (BFO_0000050 some ?Y) - - - spatially disjoint from - https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern - - - - - + @@ -1427,10 +873,15 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - - - + + + + + + + + x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y Chris Mungall @@ -1443,92 +894,13 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - - - - - - - - - inverse of develops from - Chris Mungall - David Osumi-Sutherland - Terry Meehan - - develops into - - - - - - - - - - - - - - - - - - - - - - - - - - - Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y. - Chris Mungall - David Osumi-Sutherland - has developmental precursor - FBbt - - TODO - add child relations from DOS - directly develops from - - - - - - - - - - inverse of directly develops from - developmental precursor of - - directly develops into - - - - - - - - - - - - - - - - - - - - - p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q. + + process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2. + We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit Chris Mungall David Hill Tanya Berardini @@ -1546,63 +918,10 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - - - - - - - - - - - p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q. - Chris Mungall - - negatively regulates (process to process) - - - - - negatively regulates - - - - - - - - - - - - - - - - - - - - p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q. - Chris Mungall - - positively regulates (process to process) - - - - - positively regulates - - - - - - mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974) osteoclast SubClassOf 'capable of' some 'bone resorption' A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. @@ -1622,25 +941,12 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - - - - c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. Chris Mungall has function in capable of part of - + - - - - - - - - true - @@ -1648,7 +954,6 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x Chris Mungall @@ -1663,8 +968,6 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - - A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts. The epidermis layer of a vertebrate is adjacent to the dermis. The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies. @@ -1688,25 +991,9 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - - - - - - inverse of surrounded by - Chris Mungall - - - surrounds - - - - - - Chris Mungall @@ -1719,47 +1006,11 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - - - - - - - - - - x develops from part of y if and only if there exists some z such that x develops from z and z is part of y - Chris Mungall - develops from part of - - - - - - - - - - - - - - - x develops_in y if x is located in y whilst x is developing - Chris Mungall - EHDAA2 - Jonathan Bard, EHDAA2 - develops in - - - - - inverse of ends with Chris Mungall @@ -1769,48 +1020,10 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - - - - - - - - x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. - Chris Mungall - finished by - - ends with - - - - - - - - - - - - - - - - x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y - Chris Mungall - ends with process that occurs in - - has end location - - - - - - p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p. Chris Mungall @@ -1828,13 +1041,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - - - - - - p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p. + p has output c iff c is a participant in p, c is present at the end of p, and c is not present at the beginning of p. Chris Mungall produces @@ -1846,51 +1054,10 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - - - - - - - - - - - - Mammalian thymus has developmental contribution from some pharyngeal pouch 3; Mammalian thymus has developmental contribution from some pharyngeal pouch 4 [Kardong] - - x has developmental contribution from y iff x has some part z such that z develops from y - Chris Mungall - has developmental contribution from - - - - - - - - - - - - - - - inverse of has developmental contribution from - Chris Mungall - - developmentally contributes to - - - - - - - Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p false @@ -1902,79 +1069,15 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - - - - - - - - - A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision. - c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes. - - acts upstream of - - - - - - - - - - - - - - A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway. - c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process. - affects - - acts upstream of or within - - - - - - - - - - - Inverse of developmentally preceded by - Chris Mungall - developmentally succeeded by - - - - - - - - - - - - - 'hypopharyngeal eminence' SubClassOf 'part of precursor of' some tongue - - Chris Mungall - part of developmental precursor of - - - - - - - p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss). + p results in the developmental progression of s iff p is a developmental process and s is an anatomical structure and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss). This property and its subproperties are being used primarily for the definition of GO developmental processes. The property hierarchy mirrors the core GO hierarchy. In future we may be able to make do with a more minimal set of properties, but due to the way GO is currently structured we require highly specific relations to avoid incorrect entailments. To avoid this, the corresponding genus terms in GO should be declared mutually disjoint. Chris Mungall + results_in_developmental_progression_of results in developmental progression of @@ -1986,7 +1089,6 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - an annotation of gene X to anatomical structure formation with results_in_formation_of UBERON:0000007 (pituitary gland) means that at the beginning of the process a pituitary gland does not exist and at the end of the process a pituitary gland exists. every "endocardial cushion formation" (GO:0003272) results_in_formation_of some "endocardial cushion" (UBERON:0002062) @@ -1995,6 +1097,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 + results_in_formation_of results in formation of @@ -2004,8 +1107,6 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - - Hydrozoa (NCBITaxon_6074) SubClassOf 'has habitat' some 'Hydrozoa habitat' where 'Hydrozoa habitat' SubClassOf overlaps some ('marine environment' (ENVO_00000569) and 'freshwater environment' (ENVO_01000306) and 'wetland' (ENVO_00000043)) and 'has part' some (freshwater (ENVO_00002011) or 'sea water' (ENVO_00002149)) -- http://eol.org/pages/1795/overview @@ -2021,70 +1122,21 @@ where - + - - - - p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q. - - cjm - - - holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y - causally upstream of, positive effect + + + q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w. + Because part_of is transitive, inheres in is a sub-relation of inheres in part of + Chris Mungall + + + inheres in part of + - - - - - - p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q. - - cjm - - - causally upstream of, negative effect - - - - - - - - - - - - - - - - - q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w. - Because part_of is transitive, inheres in is a sub-relation of characteristic of part of - Chris Mungall - inheres in part of - - - characteristic of part of - - - - - - - - - - true - - - - @@ -2121,34 +1173,6 @@ where - - - - - - - - - - - - - - a particular instances of akt-2 enables some instance of protein kinase activity - c enables p iff c is capable of p and c acts to execute p. - Chris Mungall - catalyzes - executes - has - is catalyzing - is executing - This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized. - - enables - - - - @@ -2160,128 +1184,10 @@ where - - - - - - - - - this relation holds between c and p when c is part of some c', and c' is capable of p. - Chris Mungall - false - part of structure that is capable of - - - - - - - - - true - - - - - - - - - - - - - - - - - - c involved_in p if and only if c enables some process p', and p' is part of p - Chris Mungall - actively involved in - enables part of - involved in - - - - - - - - - - - inverse of enables - Chris Mungall - - enabled by - - - - - - - - - - - - inverse of regulates - Chris Mungall - regulated by (processual) - - regulated by - - - - - - - - - inverse of negatively regulates - Chris Mungall - - negatively regulated by - - - - - - - - - inverse of positively regulates - Chris Mungall - - positively regulated by - - - - - - - - - - An organism that is a member of a population of organisms - is member of is a mereological relation between a item and a collection. - is member of - member part of - SIO - - member of - - - - - has member is a mereological relation between a collection and an item. SIO @@ -2290,20 +1196,6 @@ where - - - - - - inverse of has input - Chris Mungall - - - input of - - - - @@ -2328,81 +1220,11 @@ where - - - - - - - - - - - A lump of clay and a statue - x spatially_coextensive_with y if and inly if x and y have the same location - Chris Mungall - This relation is added for formal completeness. It is unlikely to be used in many practical scenarios - spatially coextensive with - - - - - - - - - - - - x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction). - Chris Mungall - has developmental potential involving - - - - - - - - - - x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y - Chris Mungall - has potential to developmentally contribute to - - - - - - - - - - x has the potential to develop into y iff x develops into y or if x is capable of developing into y - Chris Mungall - has potential to develop into - - - - - - - - - - x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y - Chris Mungall - has potential to directly develop into - - - - - inverse of upstream of Chris Mungall @@ -2411,88 +1233,18 @@ where - - - - - - - - Chris Mungall - immediately causally downstream of - - - - - - - - - - - - - - - - - - - - - - - - - - - p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q. - Chris Mungall - indirectly activates - - indirectly positively regulates - - - - - - - - - - - - - - - - - - - - - - - p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q. - Chris Mungall - indirectly inhibits - - indirectly negatively regulates - - - - - relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause. + + This relation groups causal relations between material entities and causal relations between processes This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents. To define causal relations in an activity-flow type network, we make use of 3 primitives: * Temporal: how do the intervals of the two occurrents relate? * Is the causal relation regulatory? - * Is the influence positive or negative? + * Is the influence positive or negative The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified. @@ -2505,12 +1257,6 @@ Each of these 3 primitives can be composed to yield a cross-product of different Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. causally related to - - - - relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause. - https://en.wikipedia.org/wiki/Causality - @@ -2519,8 +1265,8 @@ Each of these 3 primitives can be composed to yield a cross-product of different - - p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q. + + p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain Chris Mungall @@ -2529,26 +1275,11 @@ Each of these 3 primitives can be composed to yield a cross-product of different - - - - - - p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q. - Chris Mungall - - immediately causally upstream of - - - - - - - p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q. + p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q. We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2 Chris Mungall influences (processual) @@ -2562,7 +1293,6 @@ Each of these 3 primitives can be composed to yield a cross-product of different - inverse of causally upstream of or within Chris Mungall @@ -2572,368 +1302,64 @@ Each of these 3 primitives can be composed to yield a cross-product of different - + - - - - - - - - - - - - c involved in regulation of p if c is involved in some p' and p' regulates some p + + + 'otolith organ' SubClassOf 'composed primarily of' some 'calcium carbonate' + x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y. Chris Mungall - involved in regulation of + + + + composed primarily of - + - - - - - - - - - - - c involved in regulation of p if c is involved in some p' and p' positively regulates some p - Chris Mungall - - involved in positive regulation of + + + A relationship between a material entity and a process where the material entity has some causal role that influences the process + + causal agent in process - + - - - - - - - - - - - c involved in regulation of p if c is involved in some p' and p' negatively regulates some p + + + p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q. Chris Mungall - - involved in negative regulation of + + Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. + causal relation between processes - + - - - - - c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p - OWL does not allow defining object properties via a Union + Chris Mungall - involved in or reguates - involved in or involved in regulation of + depends on + - + - - - - - - - - A protein that enables activity in a cytosol. - c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure. + + + The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch Chris Mungall - executes activity in - enables activity in - - is active in - - - - - - - - - true - - - - - c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure. - GOC:cjm - GOC:dos - - - - - - - - - - - A relationship that holds between two entities in which the processes executed by the two entities are causally connected. - Considering relabeling as 'pairwise interacts with' - This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact. - Chris Mungall - Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules. - in pairwise interaction with - - interacts with - http://purl.obolibrary.org/obo/ro/docs/interaction-relations/ - http://purl.obolibrary.org/obo/MI_0914 - - - - - - - - - - An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other. - Chris Mungall - binds - molecularly binds with - molecularly interacts with - - http://purl.obolibrary.org/obo/MI_0915 - - - - - - - - - Axiomatization to GO to be added later - Chris Mungall - An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y. - phosphorylates - - - - - - - - - - - - - - - - - The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. - -A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B. - Chris Mungall - Vasundra Touré - molecularly controls - directly regulates activity of - - - - - - - - - - - - - - - - The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. -For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B. - Chris Mungall - Vasundra Touré - directly inhibits - molecularly decreases activity of - directly negatively regulates activity of - - - - - - - - - - - - - - - - The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. -For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B. - Chris Mungall - Vasundra Touré - directly activates - molecularly increases activity of - directly positively regulates activity of - - - - - - - - Chris Mungall - This property or its subproperties is not to be used directly. These properties exist as helper properties that are used to support OWL reasoning. - helper property (not for use in curation) - - - - - - - - - - - 'otolith organ' SubClassOf 'composed primarily of' some 'calcium carbonate' - x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y. - Chris Mungall - - - - composed primarily of - - - - - - - - - - - - - - p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c. - Chris Mungall - - has part that occurs in - - - - - - - - - true - - - - - - - - - Chris Mungall - is kinase activity - - - - - - - - - - x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships - Chris Mungall - transformation of - - - - - - - - - - x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t - Chris Mungall - - immediate transformation of - - - - - - - - - - A relationship between a material entity and a process where the material entity has some causal role that influences the process - - causal agent in process - - - - - - - - - - - p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q. - Chris Mungall - - Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. - causal relation between processes - - - - - - - - Chris Mungall - depends on - - - - - - - - - - - - The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch - Chris Mungall - - Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. - causal relation between entities + + Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. + causal relation between entities @@ -2944,9 +1370,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - A coral reef environment is determined by a particular coral reef s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s. The label for this relation is probably too general for its restricted use, where the domain is a system. It may be relabeled in future @@ -2961,45 +1384,16 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - inverse of determined by - Chris Mungall - determines (material entity to system) - - - determines - - - - - - - - - - s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w. Chris Mungall determined by part of - - - - - - - - true - @@ -3007,7 +1401,6 @@ For example, A and B may be gene products and binding of B by A positively regul - Chris Mungall causally influenced by (entity-centric) @@ -3016,95 +1409,10 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - Chris Mungall - interaction relation helper property - - http://purl.obolibrary.org/obo/ro/docs/interaction-relations/ - - - - - - - - - Chris Mungall - molecular interaction relation helper property - - - - - - - - - - - - - - - - - - - - - The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size). - Chris Mungall - Vasundra Touré - - causally influences (entity-centric) - causally influences - - - - - - - - - - p directly regulates q iff p is immediately causally upstream of q and p regulates q. - Chris Mungall - - directly regulates (processual) - - - - - directly regulates - - - - - - - - - - - - - - gland SubClassOf 'has part structure that is capable of' some 'secretion by cell' - s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p - Chris Mungall - has part structure that is capable of - - - - - - A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity. Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. Chris Mungall @@ -3114,53 +1422,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - - - - - pyrethroid -> growth - Holds between c and p if and only if c is capable of some activity a, and a regulates p. - - capable of regulating - - - - - - - - - - - - - Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p. - - capable of negatively regulating - - - - - - - - - - - - - renin -> arteriolar smooth muscle contraction - Holds between c and p if and only if c is capable of some activity a, and a positively regulates p. - - capable of positively regulating - - - - @@ -3172,367 +1433,24 @@ For example, A and B may be gene products and binding of B by A positively regul - + - - - - p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q. - - directly positively regulates (process to process) - - - - - directly positively regulates - + - + - - - - p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q. - - directly negatively regulates (process to process) - - - - - directly negatively regulates - - - - - - - - - - - - - - - a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix. - Melissa Haendel - - Note that this definition doesn't quite distinguish the output of a transformation process from a production process, which is related to the identity/granularity issue. - produces - - - - - - - - - - - a produced_by b iff some process that occurs_in b has_output a. - Melissa Haendel - - produced by - - - - - - - - - - - - - - - A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M. - cjm - 2017-12-26T19:45:49Z - realized in response to stimulus - - - - - - - - - - - - - Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P. - cjm - 2018-01-25T23:20:13Z - enables subfunction - - - - - - - - - - - - - - cjm - 2018-01-26T23:49:30Z - - acts upstream of or within, positive effect - - - - - - - - - - - - - - - cjm - 2018-01-26T23:49:51Z - - acts upstream of or within, negative effect - - - - - - - - - - - - - - c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive - - cjm - 2018-01-26T23:53:14Z - - acts upstream of, positive effect - - - - - - - - - - - - - - - c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative - - cjm - 2018-01-26T23:53:22Z - - acts upstream of, negative effect - - - - - - - - - - - cjm - 2018-03-13T23:55:05Z - causally upstream of or within, negative effect - - - - - - - - - - cjm - 2018-03-13T23:55:19Z - causally upstream of or within, positive effect - - - - - - - - - - - - - - - A drought sensitivity trait that inheres in a whole plant is realized in a systemic response process in response to exposure to drought conditions. - An inflammatory disease that is realized in response to an inflammatory process occurring in the gut (which is itself the realization of a process realized in response to harmful stimuli in the mucosal lining of th gut) - Environmental polymorphism in butterflies: These butterflies have a 'responsivity to day length trait' that is realized in response to the duration of the day, and is realized in developmental processes that lead to increased or decreased pigmentation in the adult morph. - r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r. - Austin Meier - Chris Mungall - David Osumi-Sutherland - Marie Angelique Laporte - triggered by process - realized in response to - https://docs.google.com/document/d/1KWhZxVBhIPkV6_daHta0h6UyHbjY2eIrnON1WIRGgdY/edit - - - - - triggered by process - RO:cjm - - - - - - - - - - - The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B. - Vasundra Touré - regulates activity of - - - - - - - - - p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q. - pg - 2022-09-26T06:07:17Z - indirectly causally upstream of - - - - - - - - - - p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q. - pg - 2022-09-26T06:08:01Z - indirectly regulates - - - - - - - - - - - - A diagnostic testing device utilizes a specimen. - X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y. - https://orcid.org/0000-0001-9625-1899 - https://orcid.org/0000-0003-2620-0345 - A diagnostic testing device utilizes a specimen means that the diagnostic testing device is capable of an assay, and this assay a specimen as its input. - See github ticket https://github.com/oborel/obo-relations/issues/497 - 2021-11-08T12:00:00Z - utilizes - device utilizes material - - - - - - - - - - - - - - - A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C. - - regulates characteristic - - - - - - - - - - - - - A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C. - - positively regulates characteristic - - - - - - - - - - - - - - - - - A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C. - - negatively regulates characteristic - - - - - - - - - - - - - - - - + entity @@ -3610,17 +1528,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - - - spatial region - - - - @@ -3669,12 +1576,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - - quality @@ -3708,8 +1609,7 @@ For example, A and B may be gene products and binding of B by A positively regul - - + A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts. role @@ -3757,12 +1657,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - - A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time. b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) generically dependent continuant @@ -3770,90 +1664,30 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - function - - - - - - - - - - An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time. - material entity material entity - - - - - b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001]) - continuant fiat boundary - - - - - b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001]) - - - - - - - - - - - immaterial entity - - - - - - - - - - - - - - - - - - - Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa). - gas molecular entities - gaseous molecular entities - gaseous molecular entity gas molecular entity @@ -3885,17 +1719,6 @@ For example, A and B may be gene products and binding of B by A positively regul - dioxygen - Disauerstoff - E 948 - E-948 - E948 - O2 - OXYGEN MOLECULE - Oxygen - [OO] - dioxygene - molecular oxygen dioxygen @@ -3936,16 +1759,6 @@ For example, A and B may be gene products and binding of B by A positively regul - An iron group element atom that has atomic number 26. - iron - 26Fe - Eisen - Fe - Iron - fer - ferrum - hierro - iron iron atom @@ -3984,13 +1797,6 @@ For example, A and B may be gene products and binding of B by A positively regul - Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. - molecular entity - entidad molecular - entidades moleculares - entite moleculaire - molecular entities - molekulare Entitaet molecular entity @@ -4000,8 +1806,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. - chemical entity chemical entity @@ -4010,10 +1814,7 @@ For example, A and B may be gene products and binding of B by A positively regul - - A role played by the molecular entity or part thereof within a biological context. - biological function biological role @@ -4034,7 +1835,6 @@ For example, A and B may be gene products and binding of B by A positively regul - Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)). hydroxides @@ -4044,12 +1844,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A molecular entity that contains no carbon. - anorganische Verbindungen - inorganic compounds - inorganic entity - inorganic molecular entities - inorganics inorganic molecular entity @@ -4069,17 +1863,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A salt is an assembly of cations and anions. - salt - Salz - Salze - ionic compound - ionic compounds - sal - sales - salts - sel - sels salt @@ -4089,9 +1872,6 @@ For example, A and B may be gene products and binding of B by A positively regul - iron molecular entity - iron compounds - iron molecular entities iron molecular entity @@ -4102,9 +1882,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A molecule all atoms of which have the same atomic number. - homoatomic molecule - homoatomic molecules elemental molecule @@ -4114,12 +1891,6 @@ For example, A and B may be gene products and binding of B by A positively regul - Any polyatomic entity that is an electrically neutral entity consisting of more than one atom. - molecule - Molekuel - molecula - molecules - neutral molecular compounds molecule @@ -4140,9 +1911,6 @@ For example, A and B may be gene products and binding of B by A positively regul - An oxide is a chemical compound of oxygen with other chemical elements. - oxide - oxides oxide @@ -4152,8 +1920,6 @@ For example, A and B may be gene products and binding of B by A positively regul - oxygen molecular entity - oxygen molecular entities oxygen molecular entity @@ -4173,8 +1939,6 @@ For example, A and B may be gene products and binding of B by A positively regul - sodium compounds - sodium molecular entities sodium molecular entity @@ -4194,18 +1958,6 @@ For example, A and B may be gene products and binding of B by A positively regul - An element whose atom has an incomplete d sub-shell, or which can give rise to cations with an incomplete d sub-shell. - transition element - Uebergangselement - Uebergangsmetalle - metal de transicion - metal de transition - metales de transicion - metaux de transition - transition element - transition elements - transition metal - transition metals transition element atom @@ -4223,9 +1975,7 @@ For example, A and B may be gene products and binding of B by A positively regul - - Intended use of the molecular entity or part thereof by humans. application @@ -4236,7 +1986,6 @@ For example, A and B may be gene products and binding of B by A positively regul - inorganic hydrides inorganic hydride @@ -4246,14 +1995,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A chemical entity constituting the smallest component of an element having the chemical properties of the element. - atom - atome - atomo - atoms - atomus - element - elements atom @@ -4272,10 +2013,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A molecular entity all atoms of which have the same atomic number. - homoatomic entity - homoatomic molecular entities - homoatomic molecular entity elemental molecular entity @@ -4324,8 +2061,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A nutrient is a food component that an organism uses to survive and grow. - nutrients nutrient @@ -4335,9 +2070,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms. - heteroorganic entities - organoelement compounds heteroorganic entity @@ -4356,8 +2088,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A molecular entity containing one or more atoms of an alkali metal. - alkali metal molecular entities alkali metal molecular entity @@ -4367,9 +2097,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A p-block molecular entity containing any pnictogen. - pnictogen molecular entity - pnictogen molecular entities pnictogen molecular entity @@ -4379,10 +2106,6 @@ For example, A and B may be gene products and binding of B by A positively regul - Any p-block molecular entity containing a chalcogen. - chalcogen molecular entity - chalcogen compounds - chalcogen molecular entities chalcogen molecular entity @@ -4392,9 +2115,6 @@ For example, A and B may be gene products and binding of B by A positively regul - group 8 elements - iron group element - iron group elements iron group element atom @@ -4415,9 +2135,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A molecular entity containing one or more atoms of a transition element. - transition element molecular entities - transition metal molecular entity transition element molecular entity @@ -4445,12 +2162,6 @@ For example, A and B may be gene products and binding of B by A positively regul - An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity. - elemental metal - elemental metals - metal element - metal elements - metals metal atom @@ -4460,8 +2171,6 @@ For example, A and B may be gene products and binding of B by A positively regul - d-block element - d-block elements d-block element atom @@ -4471,9 +2180,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table. - main group compounds - main group molecular entities main group molecular entity @@ -4483,8 +2189,6 @@ For example, A and B may be gene products and binding of B by A positively regul - carbon group molecular entity - carbon group molecular entities carbon group molecular entity @@ -4503,8 +2207,6 @@ For example, A and B may be gene products and binding of B by A positively regul - hydrogen compounds - hydrogen molecular entities hydrogen molecular entity @@ -4514,10 +2216,6 @@ For example, A and B may be gene products and binding of B by A positively regul - An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element. - s-block molecular entity - s-block compounds - s-block molecular entities s-block molecular entity @@ -4527,10 +2225,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A main group molecular entity that contains one or more atoms of a p-block element. - p-block compounds - p-block molecular entities - p-block molecular entitiy p-block molecular entity @@ -4540,10 +2234,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A d-block molecular entity is a molecular entity containing one or more atoms of a d-block element. - d-block molecular entity - d-block compounds - d-block molecular entities d-block molecular entity @@ -4573,7 +2263,6 @@ For example, A and B may be gene products and binding of B by A positively regul - Hydrides are chemical compounds of hydrogen with other chemical elements. hydrides @@ -4593,11 +2282,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A macromolecule formed by a living organism. - biopolymer - Biopolymere - biomacromolecules - biopolymers biomacromolecule @@ -4607,8 +2291,6 @@ For example, A and B may be gene products and binding of B by A positively regul - iron group molecular entity - iron group molecular entities iron group molecular entity @@ -4645,12 +2327,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - macromolecule - macromolecules - polymer - polymer molecule - polymers macromolecule @@ -4717,8 +2393,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A particle smaller than an atom. - subatomic particles subatomic particle @@ -4737,8 +2411,6 @@ For example, A and B may be gene products and binding of B by A positively regul - Any molecular entity consisting of more than one atom. - polyatomic entities polyatomic entity @@ -4768,9 +2440,6 @@ For example, A and B may be gene products and binding of B by A positively regul - An organochalcogen compound is a compound containing at least one carbon-chalcogen bond. - organochalcogen compound - organochalcogen compounds organochalcogen compound @@ -4781,9 +2450,6 @@ For example, A and B may be gene products and binding of B by A positively regul - An organochalcogen compound containing at least one carbon-oxygen bond. - organooxygen compound - organooxygen compounds organooxygen compound @@ -4793,9 +2459,6 @@ For example, A and B may be gene products and binding of B by A positively regul - mononuclear parent hydrides - mononuclear hydride - mononuclear hydrides mononuclear parent hydride @@ -4805,9 +2468,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A molecular entity consisting of two or more chemical elements. - chemical compound - heteroatomic molecular entities heteroatomic molecular entity @@ -4837,12 +2497,6 @@ For example, A and B may be gene products and binding of B by A positively regul - In general, a mineral is a chemical substance that is normally crystalline formed and has been formed as a result of geological processes. The term also includes metamict substances (naturally occurring, formerly crystalline substances whose crystallinity has been destroyed by ionising radiation) and can include naturally occurring amorphous substances that have never been crystalline ('mineraloids') such as georgite and calciouranoite as well as substances formed by the action of geological processes on bigenic compounds ('biogenic minerals'). - mineral - Minerale - minerales - minerals - mineraux mineral @@ -4852,10 +2506,6 @@ For example, A and B may be gene products and binding of B by A positively regul - Any molecular entity that contains carbon. - organic compounds - organic entity - organic molecular entities organic molecular entity @@ -4864,8 +2514,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - A role is particular behaviour which a material entity may exhibit. role @@ -4874,9 +2522,7 @@ For example, A and B may be gene products and binding of B by A positively regul - - A role played by the molecular entity or part thereof within a chemical context. chemical role @@ -4886,9 +2532,6 @@ For example, A and B may be gene products and binding of B by A positively regul - Nitrogenous compounds - nitrogen compounds - nitrogen molecular entities nitrogen molecular entity @@ -4917,8 +2560,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types. - Chemische Substanz chemical substance @@ -4937,16 +2578,6 @@ For example, A and B may be gene products and binding of B by A positively regul - Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism. - poisonous agent - poisonous agents - poisonous substance - poisonous substances - poisons - toxic agent - toxic agents - toxic substance - toxic substances poison @@ -4976,10 +2607,6 @@ For example, A and B may be gene products and binding of B by A positively regul - A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants. - dietary component - dietary components - food components food component @@ -4994,17 +2621,10 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - - - An astrononmical body part which delimited by physical discontinuities with its surroundings. https://en.wikipedia.org/wiki/Geographic_feature macroscopic spatial feature envoPolar @@ -5173,6 +2793,8 @@ For example, A and B may be gene products and binding of B by A positively regul SWEETRealm:Ocean TGN:21102 https://en.wikipedia.org/wiki/Ocean + Ocean + ocean ocean region envoMarine envoPolar @@ -5184,6 +2806,18 @@ For example, A and B may be gene products and binding of B by A positively regul LTER:695 https://vocab.lternet.edu/vocab/vocab/index.php?tema=695&/oceans + + + + Ocean + NASA:earthrealm + + + + + ocean + Geonames:feature + @@ -5211,6 +2845,8 @@ For example, A and B may be gene products and binding of B by A positively regul Geonames:H.SEA TGN:21103 https://en.wikipedia.org/wiki/Sea + Sea + sea channel closed sea marginal sea @@ -5227,6 +2863,24 @@ For example, A and B may be gene products and binding of B by A positively regul A large expanse of saline water usually connected with an ocean. https://en.wikipedia.org/wiki/Sea + + + + Sea + NASA:earthrealm + + + + + sea + ADL:FTT + + + + + sea + Geonames:feature + @@ -5570,7 +3224,7 @@ For example, A and B may be gene products and binding of B by A positively regul An vegetated area which overlaps a wetland ecosystem. - https://en.wikipedia.org/wiki/Wetland + https://en.wikipedia.org/wiki/Wetland @@ -5653,7 +3307,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + @@ -5704,6 +3358,8 @@ For example, A and B may be gene products and binding of B by A positively regul LTER:76 TGN:51011 https://en.wikipedia.org/wiki/Building + BUILDING + building building @@ -5712,13 +3368,25 @@ For example, A and B may be gene products and binding of B by A positively regul A permanent walled and roofed construction. USGS:SDTS - - - - - - - + + + + BUILDING + USGS:SDTS + + + + + building + Geonames:feature + + + + + + + + @@ -6043,7 +3711,7 @@ For example, A and B may be gene products and binding of B by A positively regul An area in which grasses (Graminae) are a significant component of the vegetation. - https://en.wikipedia.org/wiki/Grassland + https://en.wikipedia.org/wiki/Grassland @@ -6418,20 +4086,109 @@ For example, A and B may be gene products and binding of B by A positively regul - A valley which no longer has water flowing or accumulating over its surface. + A valley that no longer has a surface flow of water. Typically found in either Karst (limestone) or chalk terrain. https://en.wikipedia.org/wiki/Dry_valley - Typically found in either Karst (limestone) or chalk terrain. + ENVO + ENVO:00000128 dry valley - A valley which no longer has water flowing or accumulating over its surface. + A valley that no longer has a surface flow of water. Typically found in either Karst (limestone) or chalk terrain. https://en.wikipedia.org/wiki/Dry_valley + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A hydrographic feature characterized by the dominance of snow or ice. + EcoLexicon:ice + FTT:648 + SWEETRealm:LandIce + TGN:21410 + glacer + Ice + LandIce + glacial landform + glacier feature + envoPolar + Likely to be depopulated and "glacial" made into a quality or similar. + glacial feature + + + + + A hydrographic feature characterized by the dominance of snow or ice. + MA:ma + + + + + glacer + ADL:FTT + + + + + Ice + NASA:earthrealm + + + + + LandIce + NASA:earthrealm + + + + + glacial landform + Getty:TGN + + + + + glacier feature + ADL:FTT + + + + @@ -6456,10 +4213,12 @@ For example, A and B may be gene products and binding of B by A positively regul - An environmental material which is 1) composed primarily of soil or rock and included ice or organic material and 2) at or below the freezing point of water for two or more years. + Soil or rock and included ice or organic material at or below the freezing point of water (0 degrees Celsius or 32 degrees Fahrenheit) for two or more years. + EcoLexicon:permafrost LTER:408 https://en.wikipedia.org/wiki/Permafrost + Permafrost envoPolar Ice is not always present, as may be in the case of nonporous bedrock, but it frequently occurs and it may be in amounts exceeding the potential hydraulic saturation of the ground material. permafrost @@ -6467,10 +4226,16 @@ For example, A and B may be gene products and binding of B by A positively regul - An environmental material which is 1) composed primarily of soil or rock and included ice or organic material and 2) at or below the freezing point of water for two or more years. + Soil or rock and included ice or organic material at or below the freezing point of water (0 degrees Celsius or 32 degrees Fahrenheit) for two or more years. https://en.wikipedia.org/wiki/Permafrost + + + + Permafrost + NASA:earthrealm + @@ -6505,6 +4270,7 @@ For example, A and B may be gene products and binding of B by A positively regul SWEETRealm:OceanCurrent TGN:21169 https://en.wikipedia.org/wiki/Ocean_current + ocean current Subclasses of this class are to be populated by inference. Definition modified from http://en.wikipedia.org/wiki/Ocean_current. ocean current @@ -6532,48 +4298,11 @@ For example, A and B may be gene products and binding of B by A positively regul current Getty:TGN - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A landform elevated above the surrounding area. - elevation - LTER:177 - SWEETRealm:Elevation - https://en.wikipedia.org/wiki/Elevation - elevated landform - - - - A landform elevated above the surrounding area. - MA:ma + + + ocean current + ADL:FTT @@ -6592,7 +4321,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + @@ -6608,7 +4337,6 @@ For example, A and B may be gene products and binding of B by A positively regul TGN:21400 TGN:21401 geological feature - landform physiographic feature solid astronomical body part @@ -6713,7 +4441,7 @@ For example, A and B may be gene products and binding of B by A positively regul SPIRE:Swamp SWEETRealm:Swamp TGN:21324 - https://en.wikipedia.org/wiki/Swamp + https://en.wikipedia.org/wiki/Swamp Swamp swamp cienaga @@ -6723,7 +4451,7 @@ For example, A and B may be gene products and binding of B by A positively regul A wetland ecosystem in which land mass is permanently inundated by shallow bodies of water, generally with a substantial number of hummocks, or dry-land protrusions. - https://en.wikipedia.org/wiki/Swamp + https://en.wikipedia.org/wiki/Swamp @@ -6849,6 +4577,7 @@ For example, A and B may be gene products and binding of B by A positively regul + @@ -7015,18 +4744,7 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - - - - - - - - + @@ -7047,7 +4765,6 @@ For example, A and B may be gene products and binding of B by A positively regul A landform sunken or depressed below the surrounding area. Clarify that this pertains to the planetary crust and create superclass for general topological depressions. https://github.com/EnvironmentOntology/envo/issues/486 - depression EcoLexicon:depression FTT:175 FTT:215 @@ -7066,7 +4783,7 @@ For example, A and B may be gene products and binding of B by A positively regul pan (geologic) pans tidal basin - depressed landform + depression @@ -7146,7 +4863,7 @@ For example, A and B may be gene products and binding of B by A positively regul - A mass of solid material which is composed primarily of rock. + An abiotic mesoscopic feature made of the mineral material of the crust of the Earth. FTT:1010 FTT:145 Geonames:T.RK @@ -7154,103 +4871,15 @@ For example, A and B may be gene products and binding of B by A positively regul TGN:21444 piece of rock - - - - - - - - - - - - - - - - - - - - - - - A particle which 1) is composed primarily of and derived from rock or mineral sources and 2) is or was part of a portion of sand. - grain of sand - granule of sand - sand granule - In general, sand grains are larger than those of silt, but finer than those of gravel. - particle of sand - - + - A particle which 1) is composed primarily of and derived from rock or mineral sources and 2) is or was part of a portion of sand. - - - - - - - - - - - - - - - - - - - - - - - - A particle which 1) is primarily composed of quartz or feldspar and 2) is or was part of a portion of silt. - grain of silt - granule of silt - The distinction between silt and clay varies by discipline. Geologists and soil scientists usually consider the separation to occur at a particle size of 2 μm (clays being finer than silts), sedimentologists often use 4–5 μm, and colloid chemists use 1 μm. Geotechnical engineers distinguish between silts and clays based on the plasticity properties of the soil, as measured by the soils' Atterberg limits. ISO 14688 grades clay particles as being smaller than 2 μm and silt particles as being larger. Mixtures of sand, silt and less than 40% clay are called loam. - particle of silt - - - - - The distinction between silt and clay varies by discipline. Geologists and soil scientists usually consider the separation to occur at a particle size of 2 μm (clays being finer than silts), sedimentologists often use 4–5 μm, and colloid chemists use 1 μm. Geotechnical engineers distinguish between silts and clays based on the plasticity properties of the soil, as measured by the soils' Atterberg limits. ISO 14688 grades clay particles as being smaller than 2 μm and silt particles as being larger. Mixtures of sand, silt and less than 40% clay are called loam. - + An abiotic mesoscopic feature made of the mineral material of the crust of the Earth. + MA:ma - - - - - - - - - - - - - - - - - - - - - - grain of desert sand - - - - @@ -7295,7 +4924,7 @@ For example, A and B may be gene products and binding of B by A positively regul A biome is an ecosystem to which resident ecological communities have evolved adaptations. DOI:10.1186/2041-1480-4-43 - https://en.wikipedia.org/wiki/Biome + https://en.wikipedia.org/wiki/Biome @@ -7307,7 +4936,7 @@ For example, A and B may be gene products and binding of B by A positively regul major habitat type - WWF:Biome + WWF:Biome @@ -7493,7 +5122,7 @@ For example, A and B may be gene products and binding of B by A positively regul A rock is a naturally occurring solid aggregate of one or more minerals or mineraloids. MA:ma - https://en.wikipedia.org/wiki/Rock_(geology) + https://en.wikipedia.org/wiki/Rock_(geology) @@ -7560,13 +5189,7 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - - - An environmental material which is primarily composed of minerals, varying proportions of sand, silt, and clay, organic material such as humus, interstitial gases, liquids, and a broad range of resident micro- and macroorganisms. + Soil is an environmental material which is primarily composed of minerals, varying proportions of sand, silt, and clay, organic material such as humus, gases, liquids, and a broad range of resident micro- and macroorganisms. The various 'has part' and 'has quality' relations may not hold true for all soils; however, I have yet to find counter examples. Require input from a pedologist or similar. [pbuttigieg] regolith LTER:535 @@ -7584,7 +5207,7 @@ The lower boundary that separates soil from the nonsoil underneath is most diffi - An environmental material which is primarily composed of minerals, varying proportions of sand, silt, and clay, organic material such as humus, interstitial gases, liquids, and a broad range of resident micro- and macroorganisms. + Soil is an environmental material which is primarily composed of minerals, varying proportions of sand, silt, and clay, organic material such as humus, gases, liquids, and a broad range of resident micro- and macroorganisms. https://en.wikipedia.org/wiki/Soil @@ -7593,6 +5216,7 @@ The lower boundary that separates soil from the nonsoil underneath is most diffi + @@ -7613,15 +5237,15 @@ The lower boundary that separates soil from the nonsoil underneath is most diffi - + - + @@ -7633,7 +5257,7 @@ The lower boundary that separates soil from the nonsoil underneath is most diffi - A solid astronomical body part which is part of the planetary surface between the peak of an elevation or the bottom of a depression and relatively flat surrounding land. + A solid astronomical body part which is part of the planetary surface between the peak of an elevation or the bottom of a depression and relatively flat surrounding land. EcoLexicon:slope SWEETRealm:Slope https://en.wikipedia.org/wiki/Slope @@ -7644,7 +5268,7 @@ The lower boundary that separates soil from the nonsoil underneath is most diffi - A solid astronomical body part which is part of the planetary surface between the peak of an elevation or the bottom of a depression and relatively flat surrounding land. + A solid astronomical body part which is part of the planetary surface between the peak of an elevation or the bottom of a depression and relatively flat surrounding land. MA:ma @@ -7776,19 +5400,17 @@ The lower boundary that separates soil from the nonsoil underneath is most diffi - Particulate environmental material with diameters less than 500 micrometers. - Do not oversimplify the particulate environmental material subclasses with design patterns or similar. The materials have properties that their components do not - write full definitions including these where possible. + Minute solid particles with diameters less than 500 micrometers. Occurs in and may be deposited from, the atmosphere. EcoLexicon:dust SWEETRealm:Dust https://en.wikipedia.org/wiki/Dust envoPolar - Dust occurs in and may be deposited from the atmosphere. dust - Particulate environmental material with diameters less than 500 micrometers. + Minute solid particles with diameters less than 500 micrometers. Occurs in and may be deposited from, the atmosphere. https://en.wikipedia.org/wiki/Dust @@ -7838,7 +5460,7 @@ The lower boundary that separates soil from the nonsoil underneath is most diffi A rock formed by deposition of either clastic sediments, organic matter, or chemical precipitates (evaporites), followed by compaction of the particulate matter and cementation during diagenesis. - https://en.wikipedia.org/wiki/Rock_%28geology%29 + https://en.wikipedia.org/wiki/Rock_%28geology%29 @@ -8143,7 +5765,7 @@ The lower boundary that separates soil from the nonsoil underneath is most diffi - + A hospital is a building in which health care services are provided by specialized staff and equipment. https://en.wikipedia.org/wiki/Hospital hospital @@ -8512,12 +6134,6 @@ The lower boundary that separates soil from the nonsoil underneath is most diffi - - - - - - @@ -8553,37 +6169,17 @@ The lower boundary that separates soil from the nonsoil underneath is most diffi - A manufactuered product which is capable of removing heat and controlling the humidity of the air within a site. - A/C - A/C unit - air conditioner + ENVO + ENVO:00002874 air conditioning unit - - - - A manufactuered product which is capable of removing heat and controlling the humidity of the air within a site. - - - - - - - - - - - - - - - + @@ -8591,25 +6187,18 @@ The lower boundary that separates soil from the nonsoil underneath is most diffi - Particulate environmental material which 1) is composed primarily of clay particles, with only minor proportions of other materials, 2) demonstrates plasticity when wet, and 3) is capable of hardening when dried or fired. - Do not oversimplify the particulate environmental material subclasses with design patterns or similar. The materials have properties that their components do not - write full definitions including these where possible. + A group of hydrous aluminium phyllosilicate (phyllosilicates being a subgroup of silicate minerals) minerals (see clay minerals), that are typically less than 2 micrometres in diameter. Clay consists of a variety of phyllosilicate minerals rich in silicon and aluminium oxides and hydroxides which include variable amounts of structural water. EcoLexicon:clay SWEETRealm:Clay - This definition is intentionally ambiguous to support the multiple thresholds set by different authorities.The distinction between silt and clay varies by discipline. Geologists and soil scientists usually consider the separation to occur at a particle size of 2 μm (clays being finer than silts), sedimentologists often use 4–5 μm, and colloid chemists use 1 μm. Geotechnical engineers distinguish between silts and clays based on the plasticity properties of the soil, as measured by the soils' Atterberg limits. ISO 14688 grades clay particles as being smaller than 2 μm and silt particles as being larger. Mixtures of sand, silt and less than 40% clay are called loam. Similar mixtures with greater than 40% clay are often considered clay soils. + https://en.wikipedia.org/wiki/Clay clay - Particulate environmental material which 1) is composed primarily of clay particles, with only minor proportions of other materials, 2) demonstrates plasticity when wet, and 3) is capable of hardening when dried or fired. + A group of hydrous aluminium phyllosilicate (phyllosilicates being a subgroup of silicate minerals) minerals (see clay minerals), that are typically less than 2 micrometres in diameter. Clay consists of a variety of phyllosilicate minerals rich in silicon and aluminium oxides and hydroxides which include variable amounts of structural water. https://en.wikipedia.org/wiki/Clay - - - - This definition is intentionally ambiguous to support the multiple thresholds set by different authorities.The distinction between silt and clay varies by discipline. Geologists and soil scientists usually consider the separation to occur at a particle size of 2 μm (clays being finer than silts), sedimentologists often use 4–5 μm, and colloid chemists use 1 μm. Geotechnical engineers distinguish between silts and clays based on the plasticity properties of the soil, as measured by the soils' Atterberg limits. ISO 14688 grades clay particles as being smaller than 2 μm and silt particles as being larger. Mixtures of sand, silt and less than 40% clay are called loam. Similar mixtures with greater than 40% clay are often considered clay soils. - - @@ -8680,6 +6269,8 @@ The lower boundary that separates soil from the nonsoil underneath is most diffi A portion of enriched soil is a portion of soil with elevated levels of some material entity. + ENVO + ENVO:00003082 This could be demoted to an inferred class if issues with double inheritance arise. enriched soil @@ -8793,7 +6384,7 @@ The lower boundary that separates soil from the nonsoil underneath is most diffi An air filter is a device that removes some substance from air. - ORCID:0000-0002-4366-3088 + ORCID:0000-0002-4366-3088 https://en.wikipedia.org/wiki/Air_filter @@ -8853,39 +6444,6 @@ The lower boundary that separates soil from the nonsoil underneath is most diffi - - - - - - - - - - - - - - - - - - - - - - Soil which is part of some elevated land. - upland soil - - - - - Soil which is part of some elevated land. - - - - - @@ -8948,7 +6506,7 @@ The lower boundary that separates soil from the nonsoil underneath is most diffi A bird nest is the spot in which a bird lays and incubates its eggs and raises its young. - https://en.wikipedia.org/wiki/Bird_nest + https://en.wikipedia.org/wiki/Bird_nest @@ -8957,12 +6515,6 @@ The lower boundary that separates soil from the nonsoil underneath is most diffi - - - - - - A portion of environmental material is a fiat object part which forms the medium or part of the medium of an environmental system. portion of environmental material Everything under this parent must be a mass noun. All subclasses are to be understood as being composed primarily of the named entity, rather than restricted to that entity. For example, "ENVO:water" is to be understood as "environmental material composed primarly of some CHEBI:water". This class is currently being aligned to the Basic Formal Ontology. Following this alignment, its definition and the definitions of its subclasses will be revised. @@ -9129,46 +6681,32 @@ SOURCE DEFINITION: A marine upwelling is a net flow of marine water to the surfa - + - - + + - - - - - - - - + + - Particulate environmental material which is primarily composed of silt particles. - Do not oversimplify the particulate environmental material subclasses with design patterns or similar. The materials have properties that their components do not - write full definitions including these where possible. + Silt is granular material of a size somewhere between sand and clay whose mineral origin is quartz and feldspar. EcoLexicon:silt SWEETRealm:Silt https://en.wikipedia.org/wiki/Silt - This definition is intentionally ambiguous to support the multiple thresholds set by different authorities. Some authorities consider this soil material that contains 80% or more silt and less than 12% clay. In the Udden-Wentworth scale (due to Krumbein), silt particles range between 0.0039 to 0.0625 mm, larger than clay but smaller than sand particles. ISO 14688 grades silts between 0.002 mm and 0.063 mm. In actuality, silt is chemically distinct from clay, and unlike clay, grains of silt are approximately the same size in all dimensions; furthermore, their size ranges overlap. Clays are formed from thin plate-shaped particles held together by electrostatic forces, so present a cohesion. According to the U.S. Department of Agriculture Soil Texture Classification system, the sand-silt distinction is made at the 0.05 mm particle size. The USDA system has been adopted by the Food and Agriculture Organization (FAO). In the Unified Soil Classification System (USCS) and the AASHTO Soil Classification system, the sand-silt distinction is made at the 0.075 mm particle size (i.e., material passing the #200 sieve). Silts and clays are distinguished mechanically by their plasticity. + https://en.wikipedia.org/wiki/ In the Udden-Wentworth scale (due to Krumbein), silt particles range between 0.0039 to 0.0625 mm, larger than clay but smaller than sand particles. ISO 14688 grades silts between 0.002 mm and 0.063 mm. In actuality, silt is chemically distinct from clay, and unlike clay, grains of silt are approximately the same size in all dimensions; furthermore, their size ranges overlap. Clays are formed from thin plate-shaped particles held together by electrostatic forces, so present a cohesion. According to the U.S. Department of Agriculture Soil Texture Classification system, the sand-silt distinction is made at the 0.05 mm particle size. The USDA system has been adopted by the Food and Agriculture Organization (FAO). In the Unified Soil Classification System (USCS) and the AASHTO Soil Classification system, the sand-silt distinction is made at the 0.075 mm particle size (i.e., material passing the #200 sieve). Silts and clays are distinguished mechanically by their plasticity. silt - Particulate environmental material which is primarily composed of silt particles. - - - - - - This definition is intentionally ambiguous to support the multiple thresholds set by different authorities. Some authorities consider this soil material that contains 80% or more silt and less than 12% clay. In the Udden-Wentworth scale (due to Krumbein), silt particles range between 0.0039 to 0.0625 mm, larger than clay but smaller than sand particles. ISO 14688 grades silts between 0.002 mm and 0.063 mm. In actuality, silt is chemically distinct from clay, and unlike clay, grains of silt are approximately the same size in all dimensions; furthermore, their size ranges overlap. Clays are formed from thin plate-shaped particles held together by electrostatic forces, so present a cohesion. According to the U.S. Department of Agriculture Soil Texture Classification system, the sand-silt distinction is made at the 0.05 mm particle size. The USDA system has been adopted by the Food and Agriculture Organization (FAO). In the Unified Soil Classification System (USCS) and the AASHTO Soil Classification system, the sand-silt distinction is made at the 0.075 mm particle size (i.e., material passing the #200 sieve). Silts and clays are distinguished mechanically by their plasticity. - - + Silt is granular material of a size somewhere between sand and clay whose mineral origin is quartz and feldspar. + https://en.wikipedia.org/wiki/Silt @@ -9176,66 +6714,28 @@ SOURCE DEFINITION: A marine upwelling is a net flow of marine water to the surfa - - - - - - - - - - - - - - - - - - - - - - - - - + - - - - - - - - - + - Particulate environmental material which is composed primarily of particles of sand with only minor proportions of other substances. - Do not oversimplify the particulate environmental material subclasses with design patterns or similar. The materials have properties that their components do not - write full definitions including these where possible. + A naturally occurring granular material composed of finely divided rock and mineral particles. EcoLexicon:sand LTER:484 SWEETRealm:Sand https://en.wikipedia.org/wiki/Sand - This definition is intentionally ambiguous to support the multiple thresholds set by different authorities. Some authorities consider as sands soil material that contains 85% or more sand; the percentage of silt plus 1.5 times the percentage of clay does not exceed 15. coarse sand (sable grossier) 25% or more very coarse and coarse sand, and less than 50% any other one grade of sand. + ENVO + ENVO:01000017 sand - Particulate environmental material which is composed primarily of particles of sand with only minor proportions of other substances. + A naturally occurring granular material composed of finely divided rock and mineral particles. https://en.wikipedia.org/wiki/Sand - - - - This definition is intentionally ambiguous to support the multiple thresholds set by different authorities. Some authorities consider as sands soil material that contains 85% or more sand; the percentage of silt plus 1.5 times the percentage of clay does not exceed 15. coarse sand (sable grossier) 25% or more very coarse and coarse sand, and less than 50% any other one grade of sand. - https://sis.agr.gc.ca/cansis/glossary/t/index.html - @@ -9280,6 +6780,159 @@ SOURCE DEFINITION: A marine upwelling is a net flow of marine water to the surfa + + + + + + + + + + + The marine pelagic biome (pelagic meaning open sea) is that of the marine water column, from the surface to the greatest depths. + ORCID:0000-0002-4366-3088 + 2010-03-15T11:17:06Z + ENVO + ENVO:01000023 + envoPolar + marine pelagic biome + + + + + The marine pelagic biome (pelagic meaning open sea) is that of the marine water column, from the surface to the greatest depths. + ISBN:978-0-7506-3384-0 + + + + + + + + + + The neritic epipelagic zone biome comprises the marine water column above a continental shelf. + ORCID:0000-0002-4366-3088 + 2010-03-15T11:19:19Z + ENVO + ENVO:01000032 + neritic pelagic zone biome + + + + + The neritic epipelagic zone biome comprises the marine water column above a continental shelf. + ISBN:978-0-444-82619-0 + ISBN:978-0-7506-3384-0 + ORCID:0000-0002-4366-3088 + + + + + + + + + The oceanic epipelagic zone biome comprises the marine water column offshore, beyond a continental shelf. + ORCID:0000-0002-4366-3088 + 2010-03-15T11:19:19Z + ENVO + ENVO:01000033 + oceanic pelagic zone biome + + + + + The oceanic epipelagic zone biome comprises the marine water column offshore, beyond a continental shelf. + ISBN:978-0-444-82619-0 + ISBN:978-0-7506-3384-0 + ORCID:0000-0002-4366-3088 + + + + + + + + + The oceanic sea surface microlayer (SML) biome comprises the top 1000 micrometers of the marine surface waters occurring offshore, away from a continental shelf. It is the boundary layer where all exchange occurs between the atmosphere and the ocean. The chemical, physical, and biological properties of the SML differ greatly from the sub-surface water just a few centimeters beneath. + ORCID:0000-0002-4366-3088 + 2010-03-15T11:21:03Z + ENVO + ENVO:01000034 + oceanic sea surface microlayer biome + + + + + The oceanic sea surface microlayer (SML) biome comprises the top 1000 micrometers of the marine surface waters occurring offshore, away from a continental shelf. It is the boundary layer where all exchange occurs between the atmosphere and the ocean. The chemical, physical, and biological properties of the SML differ greatly from the sub-surface water just a few centimeters beneath. + ORCID:0000-0002-4366-3088 + https://en.wikipedia.org/wiki/Sea_surface_microlayer + + + + + + + + + The neritic sea surface microlayer (SML) biome comprises the top 1000 micrometers of marine surface waters occurring above a continental shelf. It is the boundary layer where all exchange occurs between the atmosphere and the ocean. The chemical, physical, and biological properties of the SML differ greatly from the sub-surface water just a few centimeters beneath. + ORCID:0000-0002-4366-3088 + 2010-03-15T11:22:09Z + ENVO + ENVO:01000041 + neritic sea surface microlayer biome + + + + + The neritic sea surface microlayer (SML) biome comprises the top 1000 micrometers of marine surface waters occurring above a continental shelf. It is the boundary layer where all exchange occurs between the atmosphere and the ocean. The chemical, physical, and biological properties of the SML differ greatly from the sub-surface water just a few centimeters beneath. + ORCID:0000-0002-4366-3088 + https://en.wikipedia.org/wiki/Sea_surface_microlayer + + + + + + + + + + + + + + + + + + + + + + + + + + + + A prominent or distinctive aspect, quality, or characteristic of environments occurring within the marine water column. + ORCID:0000-0002-4366-3088 + 2010-03-16T12:10:50Z + envoPolar + marine pelagic feature + + + + + A prominent or distinctive aspect, quality, or characteristic of environments occurring within the marine water column. + ISBN:978-0-618-45504-1 + ORCID:0000-0002-4366-3088 + + + + @@ -9342,23 +6995,38 @@ SOURCE DEFINITION: A marine upwelling is a net flow of marine water to the surfa - - - - - - - - - - + + + + + + + + + + + + + + + + + + + + + + + + + + - An environmental material which is composed primarily of particles. - Do not oversimplify this branch with design patterns or similar. The materials have properties that their components do not - write full definitions including these where possible. - particulate matter + Particulate material is an environmental material which is composed of microscopic portions of solid or liquid material suspended in another environmental material. + Subclasses should be assigned by inference. envoAtmo envoPolar - particulate environmental material + particulate matter @@ -9378,6 +7046,7 @@ SOURCE DEFINITION: A marine upwelling is a net flow of marine water to the surfa + @@ -9491,10 +7160,13 @@ SOURCE DEFINITION: A marine upwelling is a net flow of marine water to the surfa - A woodland biome which has seasonal water availability and includes trees spaced sufficiently far apart to allow an unbroken layer of grass, sedge (Cyperaceae) or rush (Juncaceae) communities to live. + A savanna biome is a woodland biome which has seasonal water availability and includes, across its entire spatial extent, trees spaced sufficiently far apart to allow an unbroken layer of grass, sedge (Cyperaceae) or rush (Juncaceae) communities to live. ORCID:0000-0002-4366-3088 2013-04-07T14:26:46Z SPIRE:Savannah_or_grassland + ENVO + ENVO:01000178 + Preliminary definition savanna biome @@ -9553,8 +7225,8 @@ SOURCE DEFINITION: A marine upwelling is a net flow of marine water to the surfa A subtropical desert biome is a desert biome which has communities adapted to temperatures above a monthly average of 18 degrees Celsius, high daily temperature ranges of approximately 20 degrees Celsius, high insolation (but lower than that of a tropical desert biome), inhibited cloud formation, and very low precipitation. Subtropical desert biomes located near coasts with cold upwellings may have cooler temperatures and reduced insolution due to fog. - WWW:http://www.earthonlinemedia.com/ebooks/tpe_3e/title_page.html - https://en.wikipedia.org/wiki/Subtropical#Semi-desert.2Fdesert_climate + WWW:http://www.earthonlinemedia.com/ebooks/tpe_3e/title_page.html + https://en.wikipedia.org/wiki/Subtropical#Semi-desert.2Fdesert_climate @@ -9564,7 +7236,6 @@ SOURCE DEFINITION: A marine upwelling is a net flow of marine water to the surfa - A savanna biome which is subject to temperate climate patterns. ORCID:0000-0002-4366-3088 2013-04-07T14:28:51Z prairie biome @@ -9732,7 +7403,6 @@ According to the E. Neef climate classification, the subtropical zone is divided - A shrubland biome which is subject to temperate climate patterns. ORCID:0000-0002-4366-3088 2013-04-07T14:40:32Z prairie biome @@ -9800,7 +7470,6 @@ According to the E. Neef climate classification, the subtropical zone is divided - A woodland biome which is subject to temperate climate patterns. ORCID:0000-0002-4366-3088 2013-04-07T15:01:04Z Preliminary definition. The semantics and definitions of "mediterranean", "subtropical", "tropical", "temperate", "polar", and similar climate types may be transferred to an "environmental condition" class once the semantics of this class have been established. @@ -9892,13 +7561,13 @@ According to the E. Neef climate classification, the subtropical zone is divided A scrubland which is located in a desert. - ORCID:0000-0001-8743-9574 + ORCID:0000-0001-8743-9574 desert scrub - ORCID:0000-0001-8743-9574 + ORCID:0000-0001-8743-9574 @@ -10237,7 +7906,7 @@ From https://en.wikipedia.org/wiki/ [A mineral] is different from a rock, which Ice which is formed from water. - + 2013-10-13T12:01:28Z LTER:262 @@ -10245,11 +7914,11 @@ From https://en.wikipedia.org/wiki/ [A mineral] is different from a rock, which envoPolar Water ice can appear transparent or opaque bluish-white color, depending on the presence of impurities or air inclusions. The addition of other materials such as soil may further alter its appearance. -When speaking about ice on Earth, usually water ice is meant - the solid, crystalline form of water found in the atmosphere as snow crystals, hail, ice pellets, etc., and on the earth's surface in forms such as hoarfrost, rime, glaze, sea ice, glacier ice, ground ice, frazil, anchor ice, etc. +When speaking about ice on Earth, usually water ice is meant - the solid, crystalline form of water found in the atmosphere as snow crystals, hail, ice pellets, etc., and on the earth's surface in forms such as hoarfrost, rime, glaze, sea ice, glacier ice, ground ice, frazil, anchor ice, etc. -This form of water is, strictly speaking, called ice Ih, the Roman numeral I distinguishing it from more than a dozen other phases and the letter h distinguishing it from the metastable cubic phase ice Ic. Ice Ih is the only one of the several known phases of water ice that is stable at commonly occurring temperatures and pressures. (Some of the other forms have very unusual properties, ice VII, for example, being stable only at pressures above 22 400 kg/cm^2, but then existing at temperatures up to about 100C.) +This form of water is, strictly speaking, called ice Ih, the Roman numeral I distinguishing it from more than a dozen other phases and the letter h distinguishing it from the metastable cubic phase ice Ic. Ice Ih is the only one of the several known phases of water ice that is stable at commonly occurring temperatures and pressures. (Some of the other forms have very unusual properties, ice VII, for example, being stable only at pressures above 22 400 kg/cm^2, but then existing at temperatures up to about 100C.) -It has an open structure with a specific gravity of 0.9166 which is slightly less than water; because the water molecules bond to their neighbors covalently only in four directions; it therefore floats on higher density water, where broken molecular bonds permit closer packing. All commonly occurring forms of ice are crystalline, although large single crystals are relatively rare except in glaciers. The ice crystal lattice possesses hexagonal symmetry that manifests itself in the gross forms of such single crystals as are sometimes found in snow. At an air pressure of one atmosphere, ice melts at 0 C by definition of the Celsius temperature scale. (Strictly speaking the equilibrium point among water, ice, and vapor occurs at +0.01C, the triple point.) On the other hand, ice does not invariably form in liquid water cooled below this temperature; it has a tendency to supercool, more so in the absence of ice nuclei. +It has an open structure with a specific gravity of 0.9166 which is slightly less than water; because the water molecules bond to their neighbors covalently only in four directions; it therefore floats on higher density water, where broken molecular bonds permit closer packing. All commonly occurring forms of ice are crystalline, although large single crystals are relatively rare except in glaciers. The ice crystal lattice possesses hexagonal symmetry that manifests itself in the gross forms of such single crystals as are sometimes found in snow. At an air pressure of one atmosphere, ice melts at 0 C by definition of the Celsius temperature scale. (Strictly speaking the equilibrium point among water, ice, and vapor occurs at +0.01C, the triple point.) On the other hand, ice does not invariably form in liquid water cooled below this temperature; it has a tendency to supercool, more so in the absence of ice nuclei. In permafrost regions, ice may occupy voids in soils and rocks and may develop in a variety of forms. Ice may be colourless to pale blue or greenish-blue. It may appear white due to included gas bubbles; in exposures, ground ice may also appear black. @@ -10260,7 +7929,7 @@ In nature ice is formed either by: (a) the freezing of water, (b) the condensati Ice which is formed from water. - https://en.wikipedia.org/wiki/Ice + https://en.wikipedia.org/wiki/Ice @@ -10371,11 +8040,12 @@ https://en.wikipedia.org/wiki/ Ecozones correspond to the floristic kingdoms of + - + @@ -10769,7 +8439,7 @@ https://en.wikipedia.org/wiki/ Ecozones correspond to the floristic kingdoms of A marine environment and enviroment which is determined by a marine water body. - NM:nm + NM:nm @@ -11093,7 +8763,6 @@ https://en.wikipedia.org/wiki/ Ecozones correspond to the floristic kingdoms of - @@ -11514,6 +9183,7 @@ https://en.wikipedia.org/wiki/ Ecozones correspond to the floristic kingdoms of + @@ -11877,7 +9547,7 @@ https://en.wikipedia.org/wiki/ Ecozones correspond to the floristic kingdoms of Masonry cement is a substance used in construction that has the disposition to set and harden and thus may be used to bind materials together. - https://en.wikipedia.org/wiki/Cement + https://en.wikipedia.org/wiki/Cement @@ -12563,7 +10233,6 @@ The building envelope provides resistance to air, water, heat, light, and noise - @@ -12771,7 +10440,6 @@ The building envelope provides resistance to air, water, heat, light, and noise - A role that is realized in some process wherein the bearer is discarded or not utilized further. This definition is preliminary. waste role @@ -12913,8 +10581,8 @@ The building envelope provides resistance to air, water, heat, light, and noise An earthquake is a process during which energy is released in an astronomical body's crust, causing the displacement of crustal parts and the generation of seismic waves. - Adapted from URL:http://www.britannica.com/science/earthquake-geology - https://en.wikipedia.org/wiki/Earthquake + Adapted from URL:http://www.britannica.com/science/earthquake-geology + https://en.wikipedia.org/wiki/Earthquake @@ -13024,6 +10692,7 @@ The building envelope provides resistance to air, water, heat, light, and noise + @@ -13137,7 +10806,7 @@ The building envelope provides resistance to air, water, heat, light, and noise - + @@ -13273,7 +10942,7 @@ The building envelope provides resistance to air, water, heat, light, and noise An environmental system which can sustain and allow the growth of an ecological population. - EnvO:EnvO + EnvO:EnvO @@ -13455,6 +11124,12 @@ The building envelope provides resistance to air, water, heat, light, and noise + + + + + + @@ -13462,6 +11137,12 @@ The building envelope provides resistance to air, water, heat, light, and noise + + + + + + A building which is publically accessible. Created for SDGIO, we treat "public" as "publically accessible" where the semantics of access are dealt with in SDGIO. public building @@ -13487,6 +11168,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A planned process during which a portion of environmental material is removed from a material entity. + This should be an OBI planned process. Pending import. Created for SDGIO and intended to be a more general form of resource extraction process. material extraction process @@ -13772,6 +11454,7 @@ The building envelope provides resistance to air, water, heat, light, and noise + @@ -13796,6 +11479,32 @@ The building envelope provides resistance to air, water, heat, light, and noise + + + + + + + + + + + + A cryosphere is that part of a planet which is primarily composed of water is in solid form. + envoAstro + envoPolar + This is a very broad and, in practice, poorly defined term. Please consider using or requesting a more specific class. + cryosphere + + + + + A cryosphere is that part of a planet which is primarily composed of water is in solid form. + https://en.wikipedia.org/wiki/Cryosphere + + + + @@ -13824,6 +11533,7 @@ The building envelope provides resistance to air, water, heat, light, and noise + @@ -14037,6 +11747,7 @@ The building envelope provides resistance to air, water, heat, light, and noise + @@ -14275,20 +11986,9 @@ The building envelope provides resistance to air, water, heat, light, and noise - A hydrological process in which irregular aggregates of snow fall to the surface of an astronomical body. - This is currently bound to water-based snow on Earth, may need revisions for interplanetary applications - - - - - - - - 2021-04-14T18:57:18.275Z - + A hydrological process in which irregular aggregates of snow fall to a planetary surface. snow fall environmental_hazards - envoCryo envoPolar snowfall @@ -14314,6 +12014,14 @@ The building envelope provides resistance to air, water, heat, light, and noise + + + + + + + + @@ -14488,26 +12196,15 @@ The building envelope provides resistance to air, water, heat, light, and noise - - - - - - - - - - - + - - A material transport process during which a volume of liquid water is transported due to a disequilibria in physical forces. + A process during which a volume of water is transported due to a disequilibria in physical forces. environmental_hazards water flow process @@ -14628,7 +12325,6 @@ The building envelope provides resistance to air, water, heat, light, and noise - @@ -14648,6 +12344,12 @@ The building envelope provides resistance to air, water, heat, light, and noise + + + + + + An process during which natural or manufactured materials and products are processed and arranged by humans or their technology into structures. The nature of "structures" must be further specified. human-directed construction process @@ -14814,7 +12516,6 @@ The building envelope provides resistance to air, water, heat, light, and noise - @@ -15354,53 +13055,9 @@ The building envelope provides resistance to air, water, heat, light, and noise - + - - - - - - - - - - - - - - - - - - - - - - - - - - - An environmental system determined by part of a living or dead animal, or a whole small animal. - Animal corpus - envoEmpo - envoMeo - envoOmics - environment associated with an animal part or small animal - - - - - Animal corpus - http://press.igsb.anl.gov/earthmicrobiome/protocols-and-standards/emp-ontology-empo/ - - - - - - - + @@ -15913,6 +13570,17 @@ The building envelope provides resistance to air, water, heat, light, and noise + + + + + + + + + + + @@ -16351,7 +14019,7 @@ The building envelope provides resistance to air, water, heat, light, and noise Ice which is primarily composed of carbon dioxide. - https://en.wikipedia.org/wiki/Ice + https://en.wikipedia.org/wiki/Ice @@ -16535,7 +14203,6 @@ The building envelope provides resistance to air, water, heat, light, and noise - @@ -16894,7 +14561,6 @@ The building envelope provides resistance to air, water, heat, light, and noise - @@ -16947,7 +14613,7 @@ The building envelope provides resistance to air, water, heat, light, and noise An ecosystem in which grasses (Graminae) are the dominant form of vegetation and determine the system's structure and dynamics. - https://en.wikipedia.org/wiki/Grassland + https://en.wikipedia.org/wiki/Grassland @@ -17076,7 +14742,7 @@ The building envelope provides resistance to air, water, heat, light, and noise TGN:21301 TGN:21304 TGN:21305 - https://en.wikipedia.org/wiki/Wetland + https://en.wikipedia.org/wiki/Wetland WETLAND Wetland EstuarineWetland @@ -17118,7 +14784,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A terrestrial ecosystem which is inundated or saturated by surface or ground water at a frequency and duration sufficient to support, and that under normal circumstances does support, a prevalence of vegetation typically adapted for life in saturated soil conditions. - https://en.wikipedia.org/wiki/Wetland + https://en.wikipedia.org/wiki/Wetland @@ -17363,40 +15029,6 @@ The building envelope provides resistance to air, water, heat, light, and noise - - - - - - - - - - - - - - - - - - - - - - A planned process during which an environmental system is modified to mitigate or nullify the impacts of flooding. - defense against flooding - defence against floods - defense against floods - flood defence - flood defence intervention - flood defense - flood defense intervention - defence against flooding - - - - @@ -17798,8 +15430,8 @@ The building envelope provides resistance to air, water, heat, light, and noise + - @@ -17946,7 +15578,7 @@ The building envelope provides resistance to air, water, heat, light, and noise - A liquid astronomical body part which is primarily composed of a continuous volume of liquid water and is held in shape or sustained by an environmental process. + A geographic feature which is primarily composed of a continuous volume of liquid water held in shape or sustained by an environmental process. Should create links to envrionmental process with new relation like "sustained_by" Similar, in spirit, to landform. hydroform @@ -17955,7 +15587,7 @@ The building envelope provides resistance to air, water, heat, light, and noise Should create links to envrionmental process with new relation like "sustained_by" - ORCID:0000-0002-4366-3088 + ORCID:0000-0002-4366-3088 @@ -18063,37 +15695,8 @@ The building envelope provides resistance to air, water, heat, light, and noise - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A material transport process during which a volume of material is displaced due to a disequilibrium in physical forces and during which 1) the qualities that inhere in that volume and 2) the processes that are unfolding within it are largely unchanged. + A material transport process during which a volume of material is displaced due to a disequilibrium in physical forces and during which 1) the qualities that inhere in that volume and 2) the processes that are unfolding within it are largely unchanged. advective transport Advective processes are disjoint from diffusive processes. Typically, fluids are advected. advective transport process @@ -18101,7 +15704,7 @@ The building envelope provides resistance to air, water, heat, light, and noise - A material transport process during which a volume of material is displaced due to a disequilibrium in physical forces and during which 1) the qualities that inhere in that volume and 2) the processes that are unfolding within it are largely unchanged. + A material transport process during which a volume of material is displaced due to a disequilibrium in physical forces and during which 1) the qualities that inhere in that volume and 2) the processes that are unfolding within it are largely unchanged. https://en.wikipedia.org/wiki/Advection https://en.wikipedia.org/wiki/Intensive_and_extensive_properties @@ -18111,7 +15714,6 @@ The building envelope provides resistance to air, water, heat, light, and noise - @@ -18169,7 +15771,7 @@ The building envelope provides resistance to air, water, heat, light, and noise - + @@ -18326,7 +15928,7 @@ The building envelope provides resistance to air, water, heat, light, and noise - + An organic environmental material which is primarily composed of gill tissue. gill tissue material @@ -18338,7 +15940,7 @@ The building envelope provides resistance to air, water, heat, light, and noise An anthropogenic environment which is bounded by the building envelope of a laboratory and in which a system of manufactured products exert control on one or more of its environmental conditions. - + laboratory environment @@ -18355,9 +15957,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A research facility in which systems of manufactured products control internal conditions and in which scientific or technological research, experiments, and measurement may be performed. - - - research laboratory + laboratory facility @@ -18393,7 +15993,7 @@ The building envelope provides resistance to air, water, heat, light, and noise An anthropisation process during which terrestrial environments - natural or anthropised - or parts thereof are altered to facilitate human activities such as agriculture, settlement, or commerce. - + land conversion land development Further examples include subdividing real estate into lots, typically for the purpose of building homes and converting unused factories into condominia. @@ -18466,7 +16066,7 @@ The building envelope provides resistance to air, water, heat, light, and noise An anthropogenic environmental process which includes all human activities undertaken in a natural, semi-natural, or anthropised environment. - + There are multiple systems of land use classification. This hierarchy aims to be generally applicable, but national systems can be added on request. land use process @@ -18505,7 +16105,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A land use process during which materials of economic value are extracted from a planet, usually from an orebody, lode, vein, seam, reef or placer deposit. - + mining terrestrial mining @@ -18526,7 +16126,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A process during which an ecosystem - natural or anthropised - is changed by the actions of humans. - + anthropogenic ecosystem conversion process @@ -18535,7 +16135,6 @@ The building envelope provides resistance to air, water, heat, light, and noise - @@ -18556,8 +16155,14 @@ The building envelope provides resistance to air, water, heat, light, and noise + + + + + + A planned process during which humans access and obtain resources, benefits, or services from a natural or anthropised ecosystem. - + planned environmental usage process @@ -18580,7 +16185,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A planned environmental usage process during which a non-renewable resource such as petroleum, natural gas, or water is extracted from an ecosystem. - + mining @@ -18631,7 +16236,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A mining process which occurs in a marine ecosystem. - + marine mining @@ -18641,6 +16246,7 @@ The building envelope provides resistance to air, water, heat, light, and noise + @@ -18660,7 +16266,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A mining process during which coal is extracted from the rocky portion of an astronomical body. - + This may be either terrestrial or marine. coal mining @@ -18691,7 +16297,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A planned environmental usage process during which an environment facilitates the movement of materials and material objects (persons or goods) from place to place, typically with the assistance of a vehicle. - + transportation usage of an environment for transportation @@ -18723,7 +16329,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A planned environmental usage process during which an environment supports 1) enterprises concerned with the provision to the public of essentials, such as electricity or water or 2) the basic network or foundation of capital facilities or community investments which are necessary to support economic and community activities. - + transportation usage of an environment for infrastructure and utilities @@ -18766,7 +16372,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A planned environmental usage process during which an environment supports the settlement and dwelling of a community of humans. - + residential This class does not include environments which are primarily used for commerce or industry. usage of an environment for residential activity @@ -18782,10 +16388,47 @@ The building envelope provides resistance to air, water, heat, light, and noise + + + + + + + + + + + + + + + + + + + + + A planned environmental usage process during which an environment supports welfare activities organised by the state or a local authority and carried out by trained personnel. + + Services include those provided by health care facilities, places of religious worship, educational facilities, police stations, fire stations, coastguard facilities, public sanitation, non-human animal welfare services, detention services, and other public services. + usage of an environment for community and social services + + + + + A planned environmental usage process during which an environment supports welfare activities organised by the state or a local authority and carried out by trained personnel. + https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/11493/144275.pdf + https://en.wikipedia.org/wiki/Land_use + https://www.eionet.europa.eu/gemet/en/concept/7816 + + + + + @@ -18799,7 +16442,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A planned environmental usage process during which an environment supports manufacturing facilities producing commodities that are sold with the expectation of recovering the total cost of production. - + This class includes environments used to support the facilities engaged with a broad variety of manufacturing activities from food and tobacco, to textiles, metals, vehicles, and chemicals. usage of an environment for industry @@ -18819,7 +16462,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A planned environmental usage process during which an environment supports facilities associated with commerce or the earning of a livelihood through means other than manufacturing or the provision of a public service. - + This class includes activities carried out in commercial offices, meeting centres, art studios, recording studios, film sets, warehouses, and distribution centres. usage of an environment for business @@ -18838,8 +16481,7 @@ The building envelope provides resistance to air, water, heat, light, and noise - A liquid astronomical body part which is continuous and is delimited by physical discontinuities or non-liquid boundaries. - + body of liquid @@ -18868,7 +16510,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A part of an astronomical body which is primarily composed of a continuous volume of liquid material, shaped by one or more environmental processes. - + liquid astronomical body part @@ -18903,7 +16545,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A part of an astronomical body which is primarily composed of a continuous volume of gaseous material, shaped by one or more environmental processes. - + gaseous astronomical body part @@ -18951,7 +16593,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A part of an astronomical body which is primarily composed of a continuous volume of liquid or gaseous material, shaped by one or more environmental processes. - + 2018-10-04T13:59:22Z fluid astronomical body part @@ -18986,7 +16628,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A building which is primarily used for the long-term habitation of humans. - + 2018-10-04T14:04:49Z domestic building @@ -19048,9 +16690,8 @@ The building envelope provides resistance to air, water, heat, light, and noise A surface layer where the solid or liquid material of an astronomical body comes into contact with an atmosphere or outer space. - + 2018-10-04T16:55:57Z - land surface a useful class: this can be used to define sub-terrestrial and sub-marine entities surface of an astronomical body @@ -19062,7 +16703,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A vehicle which is able to travel through air in an atmosphere. - + 2018-10-04T19:28:01Z aircraft @@ -19075,35 +16716,6 @@ The building envelope provides resistance to air, water, heat, light, and noise - - - - - - - - - - - - - - - - - - - - - - An elevation which is flattened across its highest surface. - - 2018-10-05T21:12:47Z - flattened elevation - - - - @@ -19116,7 +16728,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A pollution process during which artificial light with wavelengths in the visible spectrum is released into the environment. - + 2019-01-09T09:05:35Z Lichtverschmutzung This form of pollution is typically the result of urbanisation or similar land use change. @@ -19154,7 +16766,7 @@ The building envelope provides resistance to air, water, heat, light, and noise An electromagnetic radiation process during which electromagnetic waves or their quanta are emitted from a manufactured product. - + 2019-01-09T09:07:24Z anthropogenic radiation artificial radiation @@ -19177,7 +16789,7 @@ The building envelope provides resistance to air, water, heat, light, and noise Radiation from a manufactured product during which light between the wavelenghts of 380 nm and 760 nm is emitted. - + 2019-01-09T09:21:10Z optical radiation from a manufactured product visible spectrum radiation from a manufactured product @@ -19212,7 +16824,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A material transformation process during which a material's viscosity increase either through a reduction in temperature, through chemical reactions, or other physical effects. - + 2019-01-14T18:47:32Z congelation congelation process @@ -19269,7 +16881,7 @@ The building envelope provides resistance to air, water, heat, light, and noise Land which is below the freezing point of water. - + 2019-01-14T21:18:19Z http://sweetontology.net/realmCryo/FrozenGround frozen ground @@ -19319,7 +16931,7 @@ The building envelope provides resistance to air, water, heat, light, and noise Soil which is below the freezing point of water. - + 2019-01-14T21:26:59Z frozen soil @@ -19331,10 +16943,9 @@ The building envelope provides resistance to air, water, heat, light, and noise A material congelation process during which a liquid turns into a solid when its temperature is lowered below its melting point. - + 2019-01-31T21:13:16Z - envoCryo envoPolar freezing @@ -19380,7 +16991,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A freezing process during which liquid water is transformed into water ice. - + 2019-01-31T21:16:46Z freezing of water into water ice @@ -19410,7 +17021,7 @@ The building envelope provides resistance to air, water, heat, light, and noise A water surface that is part of a water body. - + 2019-02-27T21:22:13Z surface layer of a water body @@ -19434,7 +17045,7 @@ The building envelope provides resistance to air, water, heat, light, and noise An aggregate of raindrops falling to a planetary surface during a precipitation process. - + 2019-03-02T13:50:58Z rain @@ -19458,7 +17069,7 @@ The building envelope provides resistance to air, water, heat, light, and noise Rain which is composed of water droplets falling to a planetary surface during a rainfall process. - + 2019-03-02T13:52:48Z water-based rain @@ -19476,7 +17087,7 @@ The building envelope provides resistance to air, water, heat, light, and noise An ecoregion which is located on a landmass. - + 2019-03-05T17:40:44Z https://www.worldwildlife.org/biome-categories/terrestrial-ecoregions terrestrial ecoregion @@ -19507,11 +17118,24 @@ The building envelope provides resistance to air, water, heat, light, and noise + + + + + + + + + + + + + A surface layer which is part of an ocean or sea. - + 2019-03-06T01:22:01Z envoMarine envoPlastics @@ -19527,7 +17151,7 @@ Sea surface layer is also used to refer to the surfaces of oceans. A hydroform which is maintained by a continuous, directed movement of water, generated by disequilibria in a water mass. - + 2019-03-19T16:31:41Z Depth contours, shoreline configurations and interaction with other currents influence a current's direction and strength. water current @@ -19544,7 +17168,7 @@ Sea surface layer is also used to refer to the surfaces of oceans. - + @@ -19553,11 +17177,11 @@ Sea surface layer is also used to refer to the surfaces of oceans. - + A layer which is part of a cryosphere. - + 2019-04-09T13:05:25Z envoPolar cryospheric layer @@ -19587,7 +17211,7 @@ Sea surface layer is also used to refer to the surfaces of oceans. Permafrost which contains inclusions of water-based ice. - + 2019-04-09T13:45:40Z ice-bearing permafrost @@ -19598,7 +17222,6 @@ Sea surface layer is also used to refer to the surfaces of oceans. - @@ -19618,7 +17241,7 @@ Sea surface layer is also used to refer to the surfaces of oceans. A material accumulation process during which the mass of snow on a surface increases. - + 2019-04-24T18:29:18Z http://sweetontology.net/phenCryo/Accumulation This term is used both as a process and as an amount of mass added. Semantically speaking these are two distinct concepts (e.g., accumulation results in accumulation_amount of ice or snow gain), though accumulation_amount would more likely be an attribute. @@ -19632,7 +17255,7 @@ Some definitions include additional discussion of the the physics involved which A material accumulation process during which the mass of snow on a surface increases. - + @@ -19664,7 +17287,7 @@ Some definitions include additional discussion of the the physics involved which A material accumulation process during which ice forms in an environmental material or an existing accumulation of ice increases in mass. - + 2019-04-24T18:48:53Z http://sweetontology.net/phenCryo/Accumulation ice accumulation process @@ -19673,7 +17296,7 @@ Some definitions include additional discussion of the the physics involved which A material accumulation process during which ice forms in an environmental material or an existing accumulation of ice increases in mass. - + @@ -19692,7 +17315,6 @@ Some definitions include additional discussion of the the physics involved which - @@ -19711,7 +17333,7 @@ Some definitions include additional discussion of the the physics involved which A material accumulation process during which a accumulation of snow and ice forms or increases in mass. - + 2019-04-24T18:59:45Z http://sweetontology.net/phenCryo/Accumulation snow and ice accumulation process @@ -19720,7 +17342,7 @@ Some definitions include additional discussion of the the physics involved which A material accumulation process during which a accumulation of snow and ice forms or increases in mass. - + @@ -19778,7 +17400,7 @@ Some definitions include additional discussion of the the physics involved which A object which is composed primarily of water-based snow and ice. - + 2019-04-24T19:08:03Z http://sweetontology.net/phenCryo/Accumulation mass of ice and snow @@ -19812,7 +17434,7 @@ Some definitions include additional discussion of the the physics involved which A process during which microscopic solid particulates are formed from liquid materials in an atmosphere. - + 2019-05-30T21:07:51Z atmospheric formation of a solid aerosol formation of a solid aerosol in an atmosphere @@ -19852,7 +17474,7 @@ Some definitions include additional discussion of the the physics involved which That part of an atmosphere which is composed of gaseous material. - + 2019-06-02T07:52:47Z gaseous part of an atmosphere @@ -19896,7 +17518,7 @@ Some definitions include additional discussion of the the physics involved which A solid material which does not have a regularly organised internal structure. - + 2019-06-02T11:07:47Z amorphous solid @@ -19926,7 +17548,7 @@ Some definitions include additional discussion of the the physics involved which An aerosol that is suspended in an atmosphere. - + 2019-06-03T12:24:09Z atmospheric aerosol @@ -19962,7 +17584,7 @@ Some definitions include additional discussion of the the physics involved which A material transformation process during which solid or liquid particles form and are suspended in a mass of air, thus creating an aerosol. - + 2019-06-24T13:43:29Z aerosol formation process @@ -19993,7 +17615,7 @@ Some definitions include additional discussion of the the physics involved which A surface layer which is composed primarily of some liquid or gas. - + 2019-08-20T08:28:42Z fluid surface layer @@ -20024,7 +17646,7 @@ Some definitions include additional discussion of the the physics involved which A surface layer which separates two portions of fluid with respect to either 1) a discontinuity of some fluid property or 2) some derivative of one of these properties in a direction normal to the interface. - + 2019-07-22T17:29:44Z fluid interface layer @@ -20073,7 +17695,7 @@ Some definitions include additional discussion of the the physics involved which A layer which is composed primarily of some fluid. - + 2019-07-22T17:35:08Z fluid layer @@ -20085,7 +17707,7 @@ Some definitions include additional discussion of the the physics involved which A fluid interface which separates two fluid masses with differing properties. - + 2019-07-22T17:43:32Z fluid front @@ -20123,7 +17745,7 @@ Some definitions include additional discussion of the the physics involved which A fluid front which is composed primarily of gaseous material and separates at least two gaseous masses. - + 2019-07-22T17:50:08Z gaseous front @@ -20170,7 +17792,7 @@ Some definitions include additional discussion of the the physics involved which A gaseous front which separates two masses of air with different densities and is a principal cause of meteorological phenomena. - + 2019-07-22T17:57:21Z meteorological front envoAtmo @@ -20215,7 +17837,7 @@ Some definitions include additional discussion of the the physics involved which An object which is composed of a continuous mass of air. - + 2019-08-20T07:54:32Z envoAtmo air mass @@ -20245,7 +17867,7 @@ Some definitions include additional discussion of the the physics involved which A fluid surface layer which is composed primarily of some gaseous material. - + 2019-08-20T08:30:01Z gaseous surface layer @@ -20257,7 +17879,7 @@ Some definitions include additional discussion of the the physics involved which A layer which separates two portions of environmental material which possess 1) differing compositions, 2) a discontinuity of some property, or 3) some derivative of some property in a direction normal to the interface. - + 2019-08-20T09:28:10Z interface layer @@ -20286,7 +17908,7 @@ Some definitions include additional discussion of the the physics involved which An object which is composed primarily of an environmental material - + 2019-08-20T09:38:29Z This class and its subclasses refer to objects that are discrete accumulations of environmental materials, generally primarily composed of one or a few main material types. mass of environmental material @@ -20315,8 +17937,8 @@ Some definitions include additional discussion of the the physics involved which - An mass of environmental material which is composed primarily of a solid environmental material - + An object which is composed primarily of a solid environmental material + 2019-08-20T09:41:27Z This class and its subclasses refer to objects that are discrete accumulations of environmental materials, generally primarily composed of one or a few main material types. mass of solid material @@ -20360,7 +17982,7 @@ Some definitions include additional discussion of the the physics involved which An object which is composed primarily of a fluid. - + 2019-08-20T09:42:35Z fluid mass This class and its subclasses refer to objects that are discrete accumulations of environmental materials, generally primarily composed of one or a few main material types. @@ -20391,7 +18013,7 @@ Some definitions include additional discussion of the the physics involved which An object which is composed primarily of a gas. - + 2019-08-20T09:44:01Z gaseous mass This class and its subclasses refer to objects that are discrete accumulations of environmental materials, generally primarily composed of one or a few main material types. @@ -20422,7 +18044,7 @@ Some definitions include additional discussion of the the physics involved which An object which is composed primarily of a liquid. - + 2019-08-20T09:45:03Z liquid mass This class and its subclasses refer to objects that are discrete accumulations of environmental materials, generally primarily composed of one or a few main material types. @@ -20448,7 +18070,7 @@ Some definitions include additional discussion of the the physics involved which An mass of environmental materials which has appreciable quantities of several individual materials, such that the removal of one would convert the mass into a different entity. - + 2019-08-20T09:47:10Z mass of compounded environmental materials @@ -20460,7 +18082,7 @@ Some definitions include additional discussion of the the physics involved which A weather front which separates air masses of tropical and polar origin. - + 2019-08-20T13:46:42Z envoAtmo envoPolar @@ -20497,7 +18119,7 @@ Some definitions include additional discussion of the the physics involved which An environment which has a climate with continually high temperatures and with considerable precipitation, at least during part of the year. - + 2019-08-20T13:58:38Z tropical environment @@ -20532,7 +18154,7 @@ Some definitions include additional discussion of the the physics involved which An environment which has a climate with warm temperatures and with meagre precipitation. - + 2019-08-20T14:50:35Z subtropical environment @@ -20567,7 +18189,7 @@ Some definitions include additional discussion of the the physics involved which An environment which is located in a part of an astronomical body subject to polar climatic conditions. - + 2019-08-20T14:53:26Z polar environment @@ -20602,7 +18224,7 @@ Some definitions include additional discussion of the the physics involved which An environment which is located in a part of an astronomical body subject to subpolar climatic conditions. - + 2019-08-20T16:37:32Z subpolar environment @@ -20637,7 +18259,7 @@ Some definitions include additional discussion of the the physics involved which An environment which is located in a part of an astronomical body subject to temperate climatic conditions. - + 2019-08-20T16:41:52Z temperate environment @@ -20654,14 +18276,7 @@ Some definitions include additional discussion of the the physics involved which - - - - - - - An advective transport process during which a fluid moves. - + 2019-09-05T05:47:26Z mass fluid flow @@ -20673,9 +18288,9 @@ Some definitions include additional discussion of the the physics involved which A wind storm during which strong gusts of wind occur, transporting atmospheric gas in a linear fashion. - + + - 2019-09-05T06:04:47Z hurricane of the prairie plough winds @@ -20696,7 +18311,7 @@ Some definitions include additional discussion of the the physics involved which A process during which the ability of a material entity to maintain its internal organisation fails, resulting in deformation and a breakdown of that organisation. - + 2019-10-07T10:08:24Z This is a very general concept, and should likely be elevated to OBO Core rather than held in ENVO. structural collapse process @@ -20738,7 +18353,7 @@ Some definitions include additional discussion of the the physics involved which An environmental zone which includes those regions of an astronomical body which are not exposed to its atmosphere or space. - + 2019-10-07T14:22:38Z subsurface zone of an astronomical body @@ -20767,7 +18382,7 @@ Some definitions include additional discussion of the the physics involved which An ecosystem in which the composition, structure, and function of resident ecological assemblages are primarily determined by a desert. - + 2019-10-17T08:21:08Z desert ecosystem @@ -20796,7 +18411,7 @@ Some definitions include additional discussion of the the physics involved which A solid astronomical body part which is part of the landmass of that body. - + 2019-10-17T08:27:17Z part of a landmass @@ -20808,7 +18423,7 @@ Some definitions include additional discussion of the the physics involved which A large continuous area of land, either surrounded by sea or contiguous with another landmass. - + 2019-10-17T08:31:26Z landmass @@ -20834,7 +18449,6 @@ Some definitions include additional discussion of the the physics involved which - @@ -20851,22 +18465,21 @@ Some definitions include additional discussion of the the physics involved which - - A part of an astronomical body which is composed of a continuous medium bearing liquid, gaseous, and solid material in variable quantities. - + A part of an astronomical body which is primarily composed of a continuous medium bearing liquid, gaseous, and solid material in varying quantities. + 2019-10-17T08:36:00Z compound astronomical body part - A part of an astronomical body which is composed of a continuous medium bearing liquid, gaseous, and solid material in variable quantities. + A part of an astronomical body which is primarily composed of a continuous medium bearing liquid, gaseous, and solid material in varying quantities. https://en.wikipedia.org/wiki/Landform @@ -20878,7 +18491,7 @@ Some definitions include additional discussion of the the physics involved which A surface layer of an astronomical body which is primarily composed of solid material and is not covered by oceans or other bodies of water. - + 2019-10-21T10:42:26Z land @@ -20912,7 +18525,7 @@ Some definitions include additional discussion of the the physics involved which - + 2019-10-21T11:05:45Z aquatic ecosystem @@ -20935,7 +18548,7 @@ Some definitions include additional discussion of the the physics involved which - + 2019-10-21T11:06:11Z marine ecosystem @@ -20946,7 +18559,7 @@ Some definitions include additional discussion of the the physics involved which - + 2019-10-21T11:09:58Z terrestrial ecosystem @@ -20959,7 +18572,7 @@ Some definitions include additional discussion of the the physics involved which A broadleaf forest which is subject to tropical climate conditions. - + 2019-10-21T11:38:45Z tropical broadleaf forest @@ -20972,7 +18585,7 @@ Some definitions include additional discussion of the the physics involved which A broadleaf forest which is subject to temperate climate conditions. - + 2019-10-21T11:42:38Z temperate broadleaf forest @@ -21001,7 +18614,7 @@ Some definitions include additional discussion of the the physics involved which An environmental process either driven by or primarily impacting the parts or emergent properties of an ecosystem. - + 2019-10-21T11:52:55Z ecosystem process @@ -21025,7 +18638,7 @@ Some definitions include additional discussion of the the physics involved which A mixed forest which is subject to temperate climatic conditions. - + 2019-10-27T15:52:50Z temperate mixed forest @@ -21049,7 +18662,7 @@ Some definitions include additional discussion of the the physics involved which A mixed forest which is subject to tropical climatic conditions. - + 2019-10-27T16:02:01Z tropical mixed forest @@ -21073,7 +18686,7 @@ Some definitions include additional discussion of the the physics involved which A forest ecosystem which is subject to tropical climate conditions. - + 2019-10-27T16:43:20Z This class is primarily to be populated by inference. tropical forest @@ -21098,7 +18711,7 @@ Some definitions include additional discussion of the the physics involved which A forest ecosystem which is subject to subtropical climate conditions. - + 2019-10-27T16:45:16Z This class is primarily to be populated by inference. subtropical forest @@ -21123,7 +18736,7 @@ Some definitions include additional discussion of the the physics involved which A forest ecosystem which is subject to temperate climate conditions. - + 2019-10-27T16:46:49Z This class is primarily to be populated by inference. temperate forest @@ -21148,7 +18761,7 @@ Some definitions include additional discussion of the the physics involved which A grassland ecosystem which is subject to tropical climatic conditions. - + 2019-10-27T16:58:09Z tropical grassland @@ -21172,7 +18785,7 @@ Some definitions include additional discussion of the the physics involved which A grassland which is subject to subtropical climatic conditions. - + 2019-10-27T17:00:35Z subtropical grassland @@ -21183,7 +18796,7 @@ Some definitions include additional discussion of the the physics involved which - + 2019-10-27T17:00:35Z temperate grassland @@ -21195,52 +18808,13 @@ Some definitions include additional discussion of the the physics involved which A material entity which has been assembled through the intentional, instinctual, or deliberately programmed efforts of an organism or machine. - + 2019-10-29T14:50:34Z construction - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An object which is formed as a result of one or more biological processes and is composed primarily of organic material. - - 2019-10-29T15:02:58Z - organic object - - - - @@ -21258,7 +18832,7 @@ Some definitions include additional discussion of the the physics involved which A biome which is subject to tropical climatic conditions. - + 2019-11-06T15:56:17Z tropical biome @@ -21282,7 +18856,7 @@ Some definitions include additional discussion of the the physics involved which A biome which is subject to temperate climatic conditions. - + 2019-11-06T15:57:04Z temperate biome @@ -21306,7 +18880,7 @@ Some definitions include additional discussion of the the physics involved which A biome which is subject to subtropical climatic conditions. - + 2019-11-06T15:57:36Z subtropical biome @@ -21330,7 +18904,7 @@ Some definitions include additional discussion of the the physics involved which A biome which is subject to subpolar climatic conditions. - + 2019-11-06T15:58:56Z subpolar biome @@ -21359,7 +18933,7 @@ Some definitions include additional discussion of the the physics involved which A biome which is subject to alpine altitudinal conditions. - + 2019-11-06T15:59:35Z alpine biome @@ -21388,7 +18962,7 @@ Some definitions include additional discussion of the the physics involved which A biome which is subject to montane altitudinal conditions. - + 2019-11-06T16:00:33Z montane biome @@ -21417,7 +18991,7 @@ Some definitions include additional discussion of the the physics involved which A biome which is subject to arid environmental conditions. - + 2019-11-06T16:06:47Z arid biome @@ -21429,7 +19003,7 @@ Some definitions include additional discussion of the the physics involved which A process during which one entity loses energy to another entity. - + 2020-02-13T13:34:28Z energy transfer process @@ -21458,7 +19032,7 @@ Some definitions include additional discussion of the the physics involved which A material accumulation process during which the volume of liquid entity increases. - + 2020-05-18T14:39:20Z liquid accumulation process @@ -21470,7 +19044,7 @@ Some definitions include additional discussion of the the physics involved which An atmospheric wind which 1) has an increased rate relative to other winds in the same region and 2) is followed by a lull. - + 2020-05-19T21:47:51Z gust According to U.S. weather observing practice, gusts are reported when the peak wind speed reaches at least 16 knots and the variation in wind speed between the peaks and lulls is at least 9 knots. The duration of a gust is usually less than 20 seconds. @@ -21534,7 +19108,7 @@ Some definitions include additional discussion of the the physics involved which The concentration of carbon dioxide when measured in air that is part of an atmosphere. - + 2020-05-19T22:51:38Z envoAtmo envoNceas @@ -21543,273 +19117,57 @@ Some definitions include additional discussion of the the physics involved which - - - - - A landform which occurs on the surface of an astronomical body. - - 2021-05-15T09:16:23Z - geographic feature - The usage of "surface" here aligns with that of planetary surface: in contact with the atmosphere or space. The extent of the "surface" can vary. For rocky planets like Earth, astrogeologists consider the crust as the surface. - surface landform - - - - - - - - - A solid astronomical body part which has been formed from and is composed primarily of the matter of that astronomical body. - - 2021-05-15T09:40:37Z - Landforms may be natural or anthropogenic. This term has often has loose usage when referencing entities which are either subterranean or submerged below water bodies. In some cases, oceans themselves are considered landforms. Here, we have provided subclasses to resolve this ambiguity, but place oceans and other water bodies elsewhere.In later revisions, this hiearchy is likely to be reordered based on the formation processes of the entities within it. - landform - - - - - A solid astronomical body part which has been formed from and is composed primarily of the matter of that astronomical body. - - - - - - - - - - - - - - - - A disposition of a material entity which is realised when it is saturated with liquid water. - - water-holding capacity - - - - - + - - + + - - + + - - - - - - - - - + + - A mass of solid material which is either 1) a minute fragment of a larger mass or 2) one of a collection of small masses composing an aggregate. - grain - particle + A combustible black or brownish-black sedimentary rock usually occurring in rock strata in layers or veins called coal beds or coal seams. + cjm + coal - + - A mass of solid material which is either 1) a minute fragment of a larger mass or 2) one of a collection of small masses composing an aggregate. - + A combustible black or brownish-black sedimentary rock usually occurring in rock strata in layers or veins called coal beds or coal seams. + - + - - - + + - - - - - + + - - + + + + + + + + + + + + - - - - A particle which 1) is composed primarily of hydrous aluminium phyllosilicate minerals, in turn composed of aluminium and silicon ions bonded into tiny, thin plates by interconnecting oxygen and hydroxide ions, and 2) is or was part of a portion of clay. - clay particle - The distinction between silt and clay varies by discipline. Geologists and soil scientists usually consider the separation to occur at a particle size of 2 μm (clays being finer than silts), sedimentologists often use 4–5 μm, and colloid chemists use 1 μm. Geotechnical engineers distinguish between silts and clays based on the plasticity properties of the soil, as measured by the soils' Atterberg limits. ISO 14688 grades clay particles as being smaller than 2 μm and silt particles as being larger. Mixtures of sand, silt and less than 40% clay are called loam. - particle of clay - - - - - A particle which 1) is composed primarily of hydrous aluminium phyllosilicate minerals, in turn composed of aluminium and silicon ions bonded into tiny, thin plates by interconnecting oxygen and hydroxide ions, and 2) is or was part of a portion of clay. - - - - - - The distinction between silt and clay varies by discipline. Geologists and soil scientists usually consider the separation to occur at a particle size of 2 μm (clays being finer than silts), sedimentologists often use 4–5 μm, and colloid chemists use 1 μm. Geotechnical engineers distinguish between silts and clays based on the plasticity properties of the soil, as measured by the soils' Atterberg limits. ISO 14688 grades clay particles as being smaller than 2 μm and silt particles as being larger. Mixtures of sand, silt and less than 40% clay are called loam. - - - - - - - - - - - - - - - - - - - - - - - - - - - A material transport process which arises spontaneously due to physical heterogeneities in a portion of a material and forces which act throughout its volume. - Most commonly, convective flows are generated by heterogeneities in density or the effects of gravity. When the cause of the convection is unspecified, convection due to the effects of thermal expansion and buoyancy can be assumed. Convection frequently occurs in fluids, but may also take place in soft solids or mixtures where particles can flow. - convective transport process - - - - - A material transport process which arises spontaneously due to physical heterogeneities in a portion of a material and forces which act throughout its volume. - - - - - - Most commonly, convective flows are generated by heterogeneities in density or the effects of gravity. When the cause of the convection is unspecified, convection due to the effects of thermal expansion and buoyancy can be assumed. Convection frequently occurs in fluids, but may also take place in soft solids or mixtures where particles can flow. - - - - - - - - - - A physical quality of a process which is characteristic of processes that transport material within a volume due to the combined effects of material property heterogeneity and body forces across that volume. - - convective - - - - - A physical quality of a process which is characteristic of processes that transport material within a volume due to the combined effects of material property heterogeneity and body forces across that volume. - - - - - - - - - - A physical quality of a process which is characteristic of process that transport material without, themselves, changing the qualities of those materials or the processes that are unfolding within them. - - advective - - - - - A physical quality of a process which is characteristic of process that transport material without, themselves, changing the qualities of those materials or the processes that are unfolding within them. - - - - - - - - - - A material transport process during which material moves from a region of higher concentration to a region of lower concentration. - diffusion - Diffusion is also applied to the movement of energy, thus the more specific label. This class will be repositioned (but with the core of its definition intact) if we include other forms of diffusion in ENVO. - material diffusion process - - - - - A material transport process during which material moves from a region of higher concentration to a region of lower concentration. - - - - - - - - - - - - - - - - - - - - - - A combustible black or brownish-black sedimentary rock usually occurring in rock strata in layers or veins called coal beds or coal seams. - - coal - - - - - A combustible black or brownish-black sedimentary rock usually occurring in rock strata in layers or veins called coal beds or coal seams. - - - - - - - - - - - - - - - - - - - - - - - - - - - + @@ -21829,7 +19187,7 @@ Some definitions include additional discussion of the the physics involved which - + cjm iron mine @@ -21876,7 +19234,7 @@ Some definitions include additional discussion of the the physics involved which - + cjm uranium mine @@ -21888,7 +19246,7 @@ Some definitions include additional discussion of the the physics involved which a type of rock that contains sufficient minerals with important elements including metals that can be economically extracted from the rock. - + cjm ore @@ -21916,9 +19274,7 @@ Some definitions include additional discussion of the the physics involved which - Ore which contains uranium. - - The primary uranium ore mineral is uraninite + cjm uranium ore @@ -21945,7 +19301,7 @@ Some definitions include additional discussion of the the physics involved which - + cjm iron ore @@ -21972,7 +19328,7 @@ Some definitions include additional discussion of the the physics involved which - + cjm gold ore @@ -21999,7 +19355,7 @@ Some definitions include additional discussion of the the physics involved which - + cjm platinum ore @@ -22027,7 +19383,7 @@ Some definitions include additional discussion of the the physics involved which Dust which is derived from coal. - + cjm coal dust @@ -22056,7 +19412,7 @@ Some definitions include additional discussion of the the physics involved which Dust which is derived from mineral material. - + cjm mineral dust @@ -22090,7 +19446,7 @@ Some definitions include additional discussion of the the physics involved which Dust which is composed primarily of some metallic material. - + cjm metallic dust @@ -22117,7 +19473,7 @@ Some definitions include additional discussion of the the physics involved which - + cjm cement dust @@ -22145,7 +19501,7 @@ Some definitions include additional discussion of the the physics involved which Dust which is derived from clay material. - + cjm clay dust @@ -22172,7 +19528,7 @@ Some definitions include additional discussion of the the physics involved which - + cjm dust from plant parts @@ -22183,7 +19539,7 @@ Some definitions include additional discussion of the the physics involved which A surface mine that utilizes a technique of extracting rock or minerals from the earth by their removal from an open pit or borrow. - + cjm open-pit mine @@ -22195,57 +19551,6 @@ Some definitions include additional discussion of the the physics involved which - - - - - - - - - - - - - - - - - - - - - A human construction which is used to initiate and control a fission nuclear chain reaction or nuclear fusion reactions. - - nuclear reactor - - - - - A human construction which is used to initiate and control a fission nuclear chain reaction or nuclear fusion reactions. - https://en.wikipedia.org/wiki/Nuclear_reactor - - - - - - - - - A nuclear reactor which is used as a source of power. - - power reactor - nuclear power reactor - - - - - A nuclear reactor which is used as a source of power. - https://en.wikipedia.org/wiki/Nuclear_reactor - - - - @@ -22373,7 +19678,7 @@ Some definitions include additional discussion of the the physics involved which - + @@ -23137,7 +20442,7 @@ Some definitions include additional discussion of the the physics involved which A physical process during which atoms, molecules, or other consituents of a material entity are forced closer together. - + http://orcid.org/0000-0002-3410-4655 envoPolar compaction process @@ -23185,7 +20490,7 @@ Some definitions include additional discussion of the the physics involved which A process during which the mass of one or more materials, present within a given site, increases. - + http://orcid.org/0000-0002-3410-4655 envoPolar Experimental class for structural purposes not recommended for annotation. A material accumulation process ends a material transport process. @@ -23215,7 +20520,7 @@ Some definitions include additional discussion of the the physics involved which A process during which material is displaced from its original location and transported either to a new location or back to the original location. - + http://orcid.org/0000-0002-3410-4655 envoPolar Experimental class for structural purposes not recommended for annotation. @@ -23236,7 +20541,7 @@ Some definitions include additional discussion of the the physics involved which A depression which is part of a planetary crust, is of geographic scale, and is partially or completely enclosed. The general semantics of depression and geographic basin are still to be worked out see https://github.com/EnvironmentOntology/envo/issues/486 - + http://orcid.org/0000-0002-3410-4655 envoPolar geographic basin @@ -23260,9 +20565,8 @@ Some definitions include additional discussion of the the physics involved which - Particulate environmental material which is composed primarily of carbon particles formed through the incomplete combustion of hydrocarbons. - Do not oversimplify the particulate environmental material subclasses with design patterns or similar. The materials have properties that their components do not - write full definitions including these where possible. - + Particulate matter primarily composed of carbon particles formed through the incomplete combustion of hydrocarbons. + http://orcid.org/0000-0002-3410-4655 envoPolar soot @@ -23270,7 +20574,7 @@ Some definitions include additional discussion of the the physics involved which - Particulate environmental material which is composed primarily of carbon particles formed through the incomplete combustion of hydrocarbons. + Particulate matter primarily composed of carbon particles formed through the incomplete combustion of hydrocarbons. https://en.wikipedia.org/wiki/Soot @@ -23317,7 +20621,7 @@ Some definitions include additional discussion of the the physics involved which Sediment which has been transported through the marine water column, settling on the seafloor. - + http://orcid.org/0000-0002-3410-4655 marine sediments envoPolar @@ -23362,7 +20666,7 @@ Some definitions include additional discussion of the the physics involved which A material accumulation process during which solid particles are pulled through a water body by gravitation or centrifugal force and which ends when they settle on a solid surface. - + http://orcid.org/0000-0002-3410-4655 envoPolar sedimentation in a water body @@ -23388,7 +20692,7 @@ Some definitions include additional discussion of the the physics involved which A process during which a portion of some environmental material is converted into a different material or a collection of materials. A different material transformation process class (or similarly named class) pertaining to the conversion of a specific chemical into another belongs in CHEBI and or REX ontologies. - + http://orcid.org/0000-0002-3410-4655 envoPolar Experimental class for structural purposes not recommended for annotation. A material transformation process only refers to ENVO:environmental material classes (e.g. bulk and typically impure substances), rather than transformations converting a specific chemical into another. @@ -23409,7 +20713,7 @@ Some definitions include additional discussion of the the physics involved which A desublimation process during which water vapour is frozen into water ice. - + http://orcid.org/0000-0002-3410-4655 envoPolar desublimation of water vapour into ice @@ -23454,9 +20758,9 @@ Some definitions include additional discussion of the the physics involved which - A solid astronomical body part which is primarily composed of a continuous mass of snow and/or ice. + A geographic feature which is primarily composed of a continuous mass of snow and/or ice. Place holder class. Also the axiom should be changed to something along the lines of 'primairly composed of’ some ‘environmental material’ and ‘has quality’ frozen once PATO:frozen is imported. - + http://orcid.org/0000-0002-3410-4655 envoPolar cryoform @@ -23478,6 +20782,7 @@ Some definitions include additional discussion of the the physics involved which + @@ -23492,7 +20797,7 @@ Some definitions include additional discussion of the the physics involved which A mass of snow. - + http://orcid.org/0000-0002-3410-4655 accumulation of snow snow accumulation @@ -23507,7 +20812,7 @@ Some definitions include additional discussion of the the physics involved which - + @@ -23564,113 +20869,12 @@ Some definitions include additional discussion of the the physics involved which - - - - - - - - - - - - - - - - - - - - - An astronomical body part which is composed primarily of environmental materials in their frozen form. - For the moment the definition links to liquid water but in the future we might need to link to other materials for other planets, e.g., Mars. Need to make this planet agnostic. Might want to not have the definition link to years as some astronomical body parts might not be in systems with years. - -Note that in a strict sense, rocks are also frozen but in a practical sense we use terms like "solidified". This maybe something to revist if we add more astrogelogical content. - - - - - - - - 2021-04-14T18:57:18.275Z - - envoCryo - envoPolar - The term refers collectively to the portions of the earth (i.e., a planet) where water is in solid form, including snow cover, floating ice, glaciers, ice caps, ice sheets, seasonally frozen ground and perennially frozen ground (permafrost). The Cryosphere may be divided into the cryoatmosphere, the cryohydrosphere (snow cover, glaciers, and river, lake and sea Ice) and the cryolithosphere (perennially and seasonally cryotic ground, rock glacier). - -This is an Earth centric definition, other cryospheres will be considered later. Some definitions reffer to that which is sufficiently cold for pure water to freeze for at least a part of each year. - -It should be noted that "Some authorities exclude the earth's atmosphere from the Earth's Cryosphere; others restrict the term Cryosphere to the regions of the earth's crust where Permafrost exists." - -Definitions of Cryosphere come from several glossaries including: -- PhysicalGeography.net http://physicalgeography.net/ -- van Everdingen, Robert, ed., 2005 (1998 revised May 2005). Multi-language glossary of permafrost and related ground-ice terms. Boulder, CO: National Snow and Ice Data Center/World Data Center for Glaciology. [https://globalcryospherewatch.org/reference/glossary_docs/Glossary_of_Permafrost_and_Ground-Ice_IPA_2005.pdf] -- American Meteorological Society, 2015. Glossary of Meteorology [online], Available at: http://glossary.ametsoc.org/wiki/Main_Page. [Accessed 27/01/2017]. -- EU Climate-ADAPT (The European Climate Adaptation Platform), no date, Glossary, Available from: http://climate-adapt.eea.europa.eu/glossary -- IPCC, 2014: Annex II: Glossary [Agard, J., Schipper, E. L. F., (ed.)]. In: Climate Change 2014: Impacts, Adaptation, and Vulnerability. Contribution of Working Group II to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change [Birkmann, J., Campos, M., Dubeux, C., Nojiri, Y., Olsson, L., Osman-Elasha, B., Pelling, M., Prather, M. J., Rivera-Ferre M. G., Ruppel, O. C., Sallenger, A., Smith, K. R., St. Clair, A. L.,]. Cambridge University Press, Cambridge, United Kingdom and New York, NY, USA. [Link] -- NSIDC, The National Snow and Ice Data Center glossary is available at https://nsidc.org/cryosphere/glossary, Last accessed [26/01/2016]. -- Trombotto, D., P. Wainstein & L. Arenson, 2014, Guía Terminológica de la Geocriología Sudamericana” / “Terminological Guide of the South American Geocryology, 1a ed. 128 pp. [Link] -- UNESCO-WMO, 2012, International Glossary of Hydrology, 3rd edition, WMO-No. 385. [Link] - cryosphere - - - - - An astronomical body part which is composed primarily of environmental materials in their frozen form. - - - - - - The term refers collectively to the portions of the earth (i.e., a planet) where water is in solid form, including snow cover, floating ice, glaciers, ice caps, ice sheets, seasonally frozen ground and perennially frozen ground (permafrost). The Cryosphere may be divided into the cryoatmosphere, the cryohydrosphere (snow cover, glaciers, and river, lake and sea Ice) and the cryolithosphere (perennially and seasonally cryotic ground, rock glacier). - -This is an Earth centric definition, other cryospheres will be considered later. Some definitions reffer to that which is sufficiently cold for pure water to freeze for at least a part of each year. - -It should be noted that "Some authorities exclude the earth's atmosphere from the Earth's Cryosphere; others restrict the term Cryosphere to the regions of the earth's crust where Permafrost exists." - -Definitions of Cryosphere come from several glossaries including: -- PhysicalGeography.net http://physicalgeography.net/ -- van Everdingen, Robert, ed., 2005 (1998 revised May 2005). Multi-language glossary of permafrost and related ground-ice terms. Boulder, CO: National Snow and Ice Data Center/World Data Center for Glaciology. [https://globalcryospherewatch.org/reference/glossary_docs/Glossary_of_Permafrost_and_Ground-Ice_IPA_2005.pdf] -- American Meteorological Society, 2015. Glossary of Meteorology [online], Available at: http://glossary.ametsoc.org/wiki/Main_Page. [Accessed 27/01/2017]. -- EU Climate-ADAPT (The European Climate Adaptation Platform), no date, Glossary, Available from: http://climate-adapt.eea.europa.eu/glossary -- IPCC, 2014: Annex II: Glossary [Agard, J., Schipper, E. L. F., (ed.)]. In: Climate Change 2014: Impacts, Adaptation, and Vulnerability. Contribution of Working Group II to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change [Birkmann, J., Campos, M., Dubeux, C., Nojiri, Y., Olsson, L., Osman-Elasha, B., Pelling, M., Prather, M. J., Rivera-Ferre M. G., Ruppel, O. C., Sallenger, A., Smith, K. R., St. Clair, A. L.,]. Cambridge University Press, Cambridge, United Kingdom and New York, NY, USA. [Link] -- NSIDC, The National Snow and Ice Data Center glossary is available at https://nsidc.org/cryosphere/glossary, Last accessed [26/01/2016]. -- Trombotto, D., P. Wainstein & L. Arenson, 2014, Guía Terminológica de la Geocriología Sudamericana” / “Terminological Guide of the South American Geocryology, 1a ed. 128 pp. [Link] -- UNESCO-WMO, 2012, International Glossary of Hydrology, 3rd edition, WMO-No. 385. [Link] - - - - - - - - - - A human construction in which healthcare is provided. - - 2021-03-15T04:00:01.750Z - health facility - medical facility - healthcare facility - - - - - A human construction in which healthcare is provided. - - - - - Any material containing unstable atoms that emit ionizing radiation as it decays. - + 2020-08-03T18:32:42Z radioactive material @@ -23688,7 +20892,7 @@ Definitions of Cryosphere come from several glossaries including: A water ice crystal which is constituted by water molecules aligned in a hexagonal array. - + snowflake snow crystal @@ -23754,7 +20958,7 @@ Definitions of Cryosphere come from several glossaries including: See https://github.com/EnvironmentOntology/envo/issues/1102 for a possible design pattern. Uses undesirability standard, compared to polluted river's ecological impact standard. What is the relation to ENVO:00002114 'chemically enriched sediment'? Does 'element' in the definition refer to something found in the periosic table (like selenium) or the member of some set, aka an entity? - + 2021-04-05T16:38:47.162Z chemically contaminated sediment @@ -23771,17 +20975,11 @@ Uses undesirability standard, compared to polluted river's ecological impac - - - - - - A human construction which is used to transport a material which is primarily composed of liquid or gas through a system of pipes. Getting an example of use could be helpful. Are some environmental samples collected from the outside of a pipe or its fittings? Or taken from inside the pipe? Removing "transport" from the label may make the labels of sublasses more readable. However, "pipeline" alone could mean several unrelated things, like software pipelines. https://www.eia.gov/energyexplained/natural-gas/natural-gas-pipelines.php uses the term "pipeline network". ALSO could this be a transport feature? Xref https://github.com/EnvironmentOntology/envo/issues/1111. - + 2021-04-05T16:38:47.162Z Pipeline networks typically materials either from 1) a production area to a market area for consumption, 2) a production area to an area for waste disposal. pipeline network @@ -23809,7 +21007,7 @@ Xref https://github.com/EnvironmentOntology/envo/issues/1111. not placing under 'pond' class becasue contents may not be primarily be composed of water. consider revising 'pond' semantics - + 2021-04-05T16:38:47.162Z tailings pond @@ -23846,7 +21044,7 @@ consider revising 'pond' semantics - + @@ -23864,7 +21062,7 @@ consider revising 'pond' semantics The concentration of carbon dioxide when measured in soil. - + 2019-03-14T21:13:30Z envoNceas concentration of carbon dioxide in soil @@ -23914,7 +21112,7 @@ consider revising 'pond' semantics The concentration of carbon dioxide when measured in air. - + 2019-03-14T21:24:04Z envoNceas concentration of carbon dioxide in air @@ -23964,7 +21162,7 @@ consider revising 'pond' semantics The concentration of carbon dioxide when measured in seawater. - + 2019-03-14T21:35:30Z envoNceas concentration of carbon dioxide in seawater @@ -23983,7 +21181,7 @@ consider revising 'pond' semantics Organic material in soil, which consists of plant and animal residues at various stages of decomposition, cells and tissues of soil organisms, and substances synthesized by soil organisms. - + 2019-04-05T00:53:06Z envoNceas soil organic matter @@ -24013,15 +21211,20 @@ consider revising 'pond' semantics - + + + + + + A surface layer which is composed primarily of soil. - + 2019-04-12T17:35:13Z envoNceas soil surface layer @@ -24029,416 +21232,258 @@ consider revising 'pond' semantics - + - + - + - - + + - + - - + + - A layer that is composed primarily of soil. - - soil layer + The temperature of some environmental material. + environmental material temperature + temperature of environmental material - + - + - + - + - + - + - Texture which inheres in soil. - - 2021-12-26T21:49:12Z - soil texture + The temperature of some air. + air temperature + temperature of air - + - - - - - - - - - Water-holding capacity which inheres in some soil. - - - soil water-holding capacity - water-holding capacity of soil - - - - - Water-holding capacity which inheres in some soil. - - - - - - - - + - + - - - - - - - - - - - + - + - - - - - - - - - - - + - The concentration of a clay when measured in soil. - soil clay concentration - concentration of clay in soil + The quality of a environmental system process. + quality of environmental system process + environmental system process quality - + - + - + - - - - - - - - - - - + - - - - - - - - - - - - - - - - - - The concentration of a slit when measured in soil. - soil slit concentration - concentration of slit in soil + + + The porosity of some soil. + soil porosity + porosity of soil - + - + - + - - - - - - - - - - - + - - - - - - - - - - - - - - - - - - The concentration of a sand when measured in soil. - soil sand concentration - concentration of sand in soil + + + The composition of some soil. + soil composition + composition of soil - + - + - + - - - - - - - - - - - + - + - - - - - - - - - - - + - The concentration of a liquid water when measured in soil. - soil liquid water concentration - soil moisture content - soil water content - concentration of liquid water in soil + The structure of some soil. + soil structure + structure of soil - + - + - + - - - - - - - - - - - + - + - - - - - - - - - - - + - The concentration of a salt when measured in soil. - soil salt concentration - concentration of salt in soil + The acidity of some soil. + soil acidity + acidity of soil - + - + - + - - - - - - - - - - - + - + - - - - - - - - - - - + - The concentration of a soil organic matter when measured in soil. - soil soil organic matter concentration - concentration of soil organic matter in soil + The temperature of some soil. + soil temperature + temperature of soil - + - + - + - + - + - + - The temperature of some environmental material. - environmental material temperature - temperature of environmental material + The wetness of some soil. + soil wetness + wetness of soil - + - + - + @@ -24447,527 +21492,304 @@ consider revising 'pond' semantics - + - The temperature of some air. - air temperature - temperature of air + The temperature of some water. + water temperature + temperature of water - + - + - + - + - + - + - The quality of a environmental system process. - quality of environmental system process - environmental system process quality + The humidity of some soil. + soil humidity + humidity of soil - + - - - - - - - - - - - - - - - The porosity of some soil. - soil porosity - porosity of soil - - - - - - - + - + - - The composition of some soil. - soil composition - composition of soil - - - - - - - - - - - - - - - - - - - - + - The structure of some soil. - soil structure - structure of soil + The composition of some water. + water composition + composition of water - + - + - + - - + + - + - - + + - The acidity of some soil. - soil acidity - soil pH - acidity of soil + The generation of energy for use by humans + cjm + 2018-11-03T20:02:04Z + anthropogenic generation of energy - + - + - + - - + + - + - - + + - The temperature of some soil. - soil temperature - temperature of soil + cjm + 2018-11-03T20:04:34Z + generation of energy from coal - + - - - - - - - - - - - - - - - - - - - - The wetness of some soil. - soil wetness - wetness of soil + + + A disposition which is realized during the execution of work, the emission of heat, or the possession of mass. + cjm + 2018-11-03T20:22:18Z + Consider replacing with PATO class; note that PATO class is not a disposition. This should likely go into OBO Core and also have a physicist look at it. + energy - + - + + + Energy possessed by an object because of its position relative to other objects, stresses within itself, its electric charge, or other factors. + cjm + 2018-11-03T20:24:50Z + potential energy + + + + + + + + + Energy that it realized through motion. + cjm + 2018-11-03T20:25:57Z + kinetic energy + + + + + + + - + - - + + + + + + - + - - + + - The temperature of some water. - water temperature - temperature of water + + + + + + + cjm + 2018-11-03T20:26:08Z + mixed potential and kinetic energy - + - + + + potential energy that binds nucleons to form the atomic nucleus (and nuclear reactions). + cjm + 2018-11-03T20:28:07Z + nuclear energy + + + + + + + + + kinetic and potential energy in an elastic material due to a propagated deformational wave. + cjm + 2018-11-03T20:29:00Z + mechanical wave energy + + + + + + + - + - - + + - + + - - + + - The humidity of some soil. - soil humidity - humidity of soil + potential energy stored in the fields of propagated by electromagnetic radiation, including light. + cjm + 2018-11-03T20:29:21Z + radiant energy - + - + + + Kinetic energy which is realized through the microscopic motion of particles, a form of disordered mechanical energy. + cjm + 2018-11-03T20:30:20Z + thermal energy + + + + + + + - + - - + + - + - - + + - The composition of some water. - water composition - composition of water + cjm + 2018-11-03T20:47:14Z + wind wave energy - - - - - - - - - - - - - - - - - - - - - - The porosity of some snow. - snow porosity - porosity of snow - - - - - - - - - - - - - - - - - - - - - - - - - - The porosity of some water ice. - water ice porosity - porosity of water ice - - - - - - - - - - - - - - - - - - - - - - - - - - The generation of energy for use by humans - - 2018-11-03T20:02:04Z - anthropogenic generation of energy - - - - - - - - - - - - - - - - - - - - - - - - - - - 2018-11-03T20:04:34Z - generation of energy from coal - - - - - - - - - A disposition which is realized during the execution of work, the emission of heat, or the possession of mass. - - 2018-11-03T20:22:18Z - Consider replacing with PATO class; note that PATO class is not a disposition. This should likely go into OBO Core and also have a physicist look at it. - energy - - - - - - - - - Energy possessed by an object because of its position relative to other objects, stresses within itself, its electric charge, or other factors. - - 2018-11-03T20:24:50Z - potential energy - - - - - - - - - Energy which is realised through motion. - - 2018-11-03T20:25:57Z - kinetic energy - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Energy which is the sum of 1) kinetic energy and 2) potential energy. - - - 2018-11-03T20:26:08Z - mixed potential and kinetic energy - - - - - - - - - potential energy that binds nucleons to form the atomic nucleus (and nuclear reactions). - - 2018-11-03T20:28:07Z - nuclear energy - - - - - - - - - - - - - - - Potential energy which is stored in the fields of propagated by electromagnetic radiation. - - 2018-11-03T20:29:21Z - radiant energy - - - - - - - - - Kinetic energy which is realised through the microscopic motion of particles. - - - 2018-11-03T20:30:20Z - A form of disordered mechanical energy. - thermal energy - - - - - + Thermal energy which propagates through a solid (typically rocky) astronomical body. - + cjm 2018-11-03T20:47:30Z Often, this term is used specifically for thermal energy spreading from heat sources (e.g. magma chambers, the planetary core) within the Earth. However, it is also used for extraterrestrial bodies. geothermal energy @@ -24979,8 +21801,7 @@ consider revising 'pond' semantics - - + cjm 2018-11-03T20:48:18Z stellar radiation energy @@ -25049,7 +21870,7 @@ consider revising 'pond' semantics A power station which burns a fossil fuel such as coal, natural gas, or petroleum to produce electricity. - + cjm 2018-11-03T21:00:37Z fossil fuel power plant @@ -25097,7 +21918,7 @@ consider revising 'pond' semantics - + cjm 2018-11-03T21:01:16Z coal power plant @@ -25145,7 +21966,7 @@ consider revising 'pond' semantics - + cjm 2018-11-03T21:14:06Z solar power station @@ -25201,7 +22022,7 @@ consider revising 'pond' semantics - + cjm 2018-11-03T21:15:52Z OTEC power plant OTEC power station @@ -25259,7 +22080,7 @@ consider revising 'pond' semantics - + cjm 2018-11-03T21:21:48Z tidal power plant @@ -25299,32 +22120,6 @@ consider revising 'pond' semantics - - - - - - - - - - - - - - - - - - - - - - integumental system environment - - - - @@ -25401,280 +22196,7 @@ consider revising 'pond' semantics - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The concentration of dioxygen when measured in sea water. - sea water dioxygen concentration - concentration of dioxygen in sea water - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The concentration of oxygen when measured in soil. - soil oxygen concentration - concentration of oxygen in soil - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The concentration of iron molecular entity when measured in soil. - soil iron molecular entity concentration - concentration of iron molecular entity in soil - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The concentration of sodium molecular entity when measured in soil. - soil sodium molecular entity concentration - concentration of sodium molecular entity in soil - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The concentration of organic molecular entity when measured in soil. - soil organic molecular entity concentration - concentration of organic molecular entity in soil - - - - - - - - - - - - - - - A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. - biological process - physiological process - single organism process - single-organism process - biological_process - - - - - - - - - - - true - - - - - - - + @@ -25709,7 +22231,6 @@ consider revising 'pond' semantics A directive information entity with action specifications and objective specifications as parts that, when concretized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified. - A directive information entity with action specifications and objective specifications as parts, and that may be concretized as a realizable entity that, if realized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified. plan specification @@ -26188,6 +22709,7 @@ consider revising 'pond' semantics human + man Homo sapiens @@ -26216,7 +22738,6 @@ consider revising 'pond' semantics - A material entity that is designed to perform a function in a scientific investigation, but is not a reagent. device @@ -26396,16 +22917,6 @@ consider revising 'pond' semantics - - - - - A morphologic quality inhering in a bearer by virtue of the bearer's relative size, organization and distribution of its surface elements or the representation or invention of the appearance of its surface; visual and tactile surface characteristics. - texture - - - - @@ -26534,7 +23045,7 @@ consider revising 'pond' semantics - A physical quality of a fluid inhering in a bearer by virtue of the bearer's disposition to internal resistance to flow. + A physical quality of a liquid inhering in a bearer by virtue of the bearer's disposition to internal resistance to flow. viscosity @@ -26646,7 +23157,6 @@ consider revising 'pond' semantics - An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light. optical quality @@ -26726,18 +23236,6 @@ consider revising 'pond' semantics - - - - - - A position which is relatively high. - high position - increased position - - - - @@ -26870,19 +23368,6 @@ consider revising 'pond' semantics - - - - - - An elevation which is relatively high. - high elevation - elevated - increased elevation - - - - @@ -26911,7 +23396,7 @@ consider revising 'pond' semantics - An organismal quality inhering in a bearer by virtue of the bearer's disposition to lose an entity by natural process. + An organismal quality inhering in a bearer by virtue of the bearer's disposition to lose an entitity by natural process. shedability @@ -27211,16 +23696,6 @@ consider revising 'pond' semantics - - - - - A quality of a substance on which or through which electromagnetic radiation impinges or traverses with respect to radiation. This substance quality changes the quality of the incident radiation with respect to any of: intensity, direction, scatter and wavelength. - quality of interaction of a substance with electromagnetic radiation - - - - @@ -27239,7 +23714,6 @@ consider revising 'pond' semantics - @@ -27302,7 +23776,6 @@ Classes for population already exist in IDO ('organism population', I - A material entity that is one or more organisms, viruses or viroids. organismal entity @@ -27351,20 +23824,20 @@ Classes for population already exist in IDO ('organism population', I A plant structure (PO:0005679) which is a whole organism. - POC:curators + POC:curators planta entera (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 植物体全体 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -27432,20 +23905,20 @@ Classes for population already exist in IDO ('organism population', I A shoot axis (PO:0025029) that is the most distal part of a shoot system (PO:0009006) and has as parts a shoot apical meristem (PO:0020148) and the youngest primordia (PO:0025127). - POC:curators + POC:curators &#225pice del epiblasto (epiblastema) (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo シュート頂、茎頂 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -27473,21 +23946,21 @@ Classes for population already exist in IDO ('organism population', I A portion of meristem tissue (PO:0009013) which is the organogenic region of the meristem, characterized by higher rates of cell division. - ISBN:0521288959 - TAIR_curator:Leonore_Reiser + ISBN:0521288959 + TAIR_curator:Leonore_Reiser zona perif&#233rica (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 周辺帯 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -27512,21 +23985,21 @@ Classes for population already exist in IDO ('organism population', I A native plant cell (PO:0025606) synthesizing protoplasm and producing new cells by division and with only a primary cell wall. - ISBN:0471245208 - POC:Laurel_Cooper + ISBN:0471245208 + POC:Laurel_Cooper c&#233lula meristem&#225tica (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 分裂組織細胞 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -27557,21 +24030,21 @@ Classes for population already exist in IDO ('organism population', I A primordium (PO:0025127) that develops from a root anlagen (PO:0025433) and is committed to the development of a root (PO:0009005). - ISBN:0521288959 - POC:curators + ISBN:0521288959 + POC:curators primordio de ra&#237z (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 根原基（可視的） (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -27606,20 +24079,20 @@ Classes for population already exist in IDO ('organism population', I A lateral plant organ (PO:0009008) produced by a shoot apical meristem (PO:0020148). - POC:curators + POC:curators filoma (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo フィロム、葉(的）器官 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -27649,21 +24122,21 @@ Classes for population already exist in IDO ('organism population', I A portion of meristem tissue (PO:0009013) that is part of a shoot system (PO:0009006). - Gramene:Pankaj_Jaiswal - POC:Laurel_Cooper + Gramene:Pankaj_Jaiswal + POC:Laurel_Cooper meristema del epiblasto (epiblastema) (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo シュート分裂組織 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -27688,21 +24161,21 @@ Classes for population already exist in IDO ('organism population', I A portion of meristem tissue (PO:0009013) that is the outer layer of an apical meristem (PO:0020144), or the outer layer of a plant embryo proper (PO:0000001), and gives rise to a portion of epidermis (PO:0005679). - ISBN:0471245208 - POC:Laurel_Cooper + ISBN:0471245208 + POC:Laurel_Cooper protodermis (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 前表皮、原表皮 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -27736,7 +24209,7 @@ Classes for population already exist in IDO ('organism population', I A plant structure development stage (PO:0009012) that has as primary participant a whole plant (PO:0000003). - POC:curators + POC:curators @@ -27750,7 +24223,7 @@ Classes for population already exist in IDO ('organism population', I A cell which is a plant structure (PO:0009011). cell (broad) - GO:0005623 + GO:0005623 PO_GIT:56 c&#233lula vegetal (Spanish, exact) 植物細胞 (Japanese, exact) @@ -27766,21 +24239,21 @@ Classes for population already exist in IDO ('organism population', I A cell which is a plant structure (PO:0009011). - GO:0005623 - POC:curators + GO:0005623 + POC:curators c&#233lula vegetal (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 植物細胞 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -27829,44 +24302,44 @@ Classes for population already exist in IDO ('organism population', I A plant axis (PO:0025004) that lacks shoot axis nodes (PO:0005004) and usually grows indeterminately. - ISBN:978-0879015329 - ISBN:9780964022157 - NYBG:Brandon_Sinn - NYBG:Dario_Cavaliere - POC:Laurel_Cooper - POC:curators + ISBN:978-0879015329 + ISBN:9780964022157 + NYBG:Brandon_Sinn + NYBG:Dario_Cavaliere + POC:Laurel_Cooper + POC:curators ra&#237z (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo radices (exact, plural) - FNA:3c46e84c-23e4-416b-91cd-2f7c42e4b13d + FNA:3c46e84c-23e4-416b-91cd-2f7c42e4b13d radix (exact) - FNA:e6315684-fc99-4976-b39d-b356c4b7e7fd + FNA:e6315684-fc99-4976-b39d-b356c4b7e7fd 根 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki climbing root (narrow) - FNA:bf0ce902-e91c-401a-92a8-26b20142ce5f + FNA:bf0ce902-e91c-401a-92a8-26b20142ce5f @@ -27896,35 +24369,35 @@ Classes for population already exist in IDO ('organism population', I A collective plant organ structure (PO:0025007) that produces shoot-borne portions of meristem tissue (PO:0009013) and the plant structures (PO:0009011) that arise from them. - POC:Laurel_Cooper - POC:curators + POC:Laurel_Cooper + POC:curators sistema de epiblasto (epiblastema) (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo シュート系、苗条系 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki thalli (related) - FNA:d1431b5c-7b86-46a0-8d3c-bd426fe12c85 + FNA:d1431b5c-7b86-46a0-8d3c-bd426fe12c85 thallus (related) - FNA:02756ad4-a09c-48d7-8754-903254e557a9 + FNA:02756ad4-a09c-48d7-8754-903254e557a9 @@ -27953,21 +24426,21 @@ Classes for population already exist in IDO ('organism population', I A plant structure (PO:0009011) that consists predominantly of similarly specialized plant cells (PO:0009002) of one or more types. - POC:curators - TAIR_curator:Leonore_Reiser + POC:curators + TAIR_curator:Leonore_Reiser porci&#243n de un tejido vegetal (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 植物組織の一部 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -27994,27 +24467,27 @@ Classes for population already exist in IDO ('organism population', I A multi-tissue plant structure (PO:0025496) that is a functional unit, is a proper part of a whole plant (PO:0000003), and includes portions of plant tissue (PO:0009007) of at least two different types that derive from a common developmental path. - POC:curators + POC:curators &#243rgano vegetal (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 植物 器官 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki simple plant organ (related) - PATO:01503 + PATO:01503 @@ -28037,28 +24510,28 @@ Classes for population already exist in IDO ('organism population', I A plant anatomical entity (PO:0025131) that is, or was, part of a plant, or was derived from a part of a plant. - CARO:0000003 - POC:curators + CARO:0000003 + POC:curators estructura vegetal (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 植物 構造 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki 'Part' includes both proper parts and the whole plant. CARO:0000003 'connected anatomical structure' is defined as: Material anatomical entity that is a single connected structure with inherent 3D shape, generated by coordinated expression of the organism's own genome. - PO:cooperl + PO:cooperl @@ -28082,22 +24555,22 @@ Classes for population already exist in IDO ('organism population', I A stage in the life of a plant structure (PO:0009011) during which the plant structure undergoes developmental processes. - BFO:0000003 - GO:0032502 - POC:curators + BFO:0000003 + GO:0032502 + POC:curators etapa de desarrollo de estructura vegetal (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo Arabidopsis growth (related) - TAIR:0000205 + TAIR:0000205 @@ -28127,21 +24600,21 @@ Classes for population already exist in IDO ('organism population', I A portion of plant tissue (PO:0009007) in which plant cells (PO:0009002) have retained their embryonic characteristics, or have reverted to them secondarily, and that divide to produce new cells that can undergo differentiation to form mature tissues, i.e. they have a capacity for morphogenesis and growth. - APweb:Glossary - Gramene:Pankaj_Jaiswal + APweb:Glossary + Gramene:Pankaj_Jaiswal meristema (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 分裂組織 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -28173,22 +24646,22 @@ Classes for population already exist in IDO ('organism population', I A maximal portion of meristem tissue (PO:0009013) located at a shoot apex (PO:0000037) or root tip (PO:0000025). - Gramene:Pankaj_Jaiswal - POC:Laurel_Cooper - POC:curators + Gramene:Pankaj_Jaiswal + POC:Laurel_Cooper + POC:curators meristema apical (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 頂端分裂組織 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -28221,21 +24694,21 @@ Classes for population already exist in IDO ('organism population', I A shoot system meristem (PO:0006079) formed at the apex of the shoot axis (PO:0025029), including those originating from an axillary bud meristem (PO:0000232). - POC:Laurel_Cooper - UMSL_curator:fz + POC:Laurel_Cooper + UMSL_curator:fz meristema apical del epiblasto (epiblastema) (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 茎頂分裂組織 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -28261,26 +24734,26 @@ Classes for population already exist in IDO ('organism population', I An axial plant organ (PO:0009008). - POC:curators + POC:curators eje de la planta (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo plant axes (exact, plural) - FNA:2355281f-ab10-4ae2-a3d8-672cace068a8 + FNA:2355281f-ab10-4ae2-a3d8-672cace068a8 植物軸（軸柱） (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -28312,20 +24785,20 @@ Classes for population already exist in IDO ('organism population', I A collective plant structure (PO:0025497) that is a proper part of a whole plant (PO:0000003), and is composed of two or more adjacent plant organs (PO:0009008) and the associated portions of plant tissue (PO:0009007). - POC:curators + POC:curators estructura vegetal colectiva de &#243rgano (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 集合植物器官構造 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -28358,27 +24831,27 @@ Classes for population already exist in IDO ('organism population', I A collective plant organ structure (PO:0025007) that produces root meristems (PO:0006085), the plant structures (PO:0009011) that arise from them and the parts thereof. - POC:Laurel_Cooper - POC:curators + POC:Laurel_Cooper + POC:curators root (broad) - FNA:b7ce680b-c6ed-4d2e-81e6-66970f7deff9 + FNA:b7ce680b-c6ed-4d2e-81e6-66970f7deff9 sistema de ra&#237z (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 根系 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -28416,20 +24889,20 @@ Classes for population already exist in IDO ('organism population', I A plant axis (PO:0025004) that is part of a shoot system (PO:0009006). - POC:curators + POC:curators eje del epiblasto (epiblastema) (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo シュート軸 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -28455,20 +24928,20 @@ Classes for population already exist in IDO ('organism population', I A phyllome (PO:0006001) that is not associated with a reproductive structure. - POC:curators + POC:curators hoja (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 葉 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -28496,20 +24969,20 @@ Classes for population already exist in IDO ('organism population', I A portion of meristem tissue (PO:0009013) that has as parts protoderm (PO:0006210) and sub-epidermal meristematic tissue and is committed to the development of a particular plant structure (PO:0009011). - POC:curators + POC:curators primordio (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 原基（可視的） (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -28548,21 +25021,21 @@ Classes for population already exist in IDO ('organism population', I A primordium (PO:0025127) that develops from a phyllome anlagen (PO:0025430) and is part of a shoot apex (PO:0000037) and is committed to the development of a phyllome (PO:0006001). - PMID:11572953 - POC:curators + PMID:11572953 + POC:curators primordio del filoma (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo フィロム原基（可視的） (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -28598,35 +25071,35 @@ Classes for population already exist in IDO ('organism population', I - cjm + cjm An anatomical entity that is or was part of a plant. - BFO:0000004 - CARO:0000000 - POC:curators + BFO:0000004 + CARO:0000000 + POC:curators entidad anat&#243mica vegetal (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 植物 解剖学（形態）的実体 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki Includes both material entities such as plant structures and immaterial entities such as plant anatomical spaces. CARO:0000000 'anatomical entity' is defined as: A part of a cellular organism that is either an immaterial entity or a material entity with granularity aboove the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. Refers to BFO:0000004 'independent continuant'. - CAROC:Brownsville2014 + CAROC:Brownsville2014 @@ -28650,20 +25123,20 @@ Classes for population already exist in IDO ('organism population', I A maximal whole plant development stage. - POC:curators + POC:curators vida de la planta entera (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 植物体の一生 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -28694,14 +25167,14 @@ Classes for population already exist in IDO ('organism population', I A portion of meristem tissue (PO:0009013) that is part of a peripheral zone (PO:0000225) of a shoot apical meristem (PO:0020148) and will give rise to a phyllome primordium (PO:0025128). - POC:Laurel_Cooper - POC:curators + POC:Laurel_Cooper + POC:curators フィロム原基 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -28726,20 +25199,20 @@ Classes for population already exist in IDO ('organism population', I A portion of meristem tissue (PO:0009013) that is committed to the development of a root primordium (PO:0005029). - POC:curators + POC:curators precursor de ra&#237 (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 根原基 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -28765,20 +25238,20 @@ Classes for population already exist in IDO ('organism population', I A plant structure (PO:0009011) that has as parts two or more portions of plant tissue (PO:0009007) of at least two different types and which through specific morphogenetic processes forms a single structural unit demarcated by primarily bona-fide boundaries from other structural units of different types. CARO:0000055 - POC:curators + POC:curators estructura vegetal con m&#250ltiples tejidos (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 複数の組織からなる植物構造 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -28803,20 +25276,20 @@ Classes for population already exist in IDO ('organism population', I A plant structure (PO:0009011) that is a proper part of a whole plant (PO:0000003) and includes two or more adjacent plant organs (PO:0009008) or adjacent cardinal organ parts (PO:0025001), along with any associated portions of plant tissue (PO:0009007). - POC:curators + POC:curators estructura vegetal colectiva (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 集合的植物構造 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -28839,7 +25312,7 @@ Classes for population already exist in IDO ('organism population', I A plant cell (PO:0009002) that is either part of a multicellular whole plant (PO:0000003) 'in vivo' or a unicellular organism 'in natura' (i.e. part of a natural environment). - POC:Laurel_Cooper + POC:Laurel_Cooper @@ -28874,20 +25347,20 @@ Classes for population already exist in IDO ('organism population', I A whole plant development stage (PO:0007033) that has as primary participant a whole plant (PO:0000003) during the interval between fertilization (or apogamy) and death. - POC:curators + POC:curators fase esporof&#237tica (Spanish, exact) - POC:Maria_Alejandra_Gandolfo + POC:Maria_Alejandra_Gandolfo 胞子体発生過程 (Japanese, exact) - NIG:Yukiko_Yamazaki + NIG:Yukiko_Yamazaki @@ -28895,784 +25368,170 @@ Classes for population already exist in IDO ('organism population', I - - - A material entity consisting of multiple components that are causally integrated. - May be replaced by a BFO class, as discussed in http://www.jbiomedsem.com/content/4/1/43 - Chris Mungall - http://www.jbiomedsem.com/content/4/1/43 - system - - - - - - - - - Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. - biological structure - connected biological structure - anatomical structure - - - - - - - - - - - - - - - Anatomical structure that performs a specific function or group of functions [WP]. - anatomical unit - body organ - element - organ - - - - - - - - - - - - - - - - The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm. - surface (external) ectoderm - surface ectoderm - external ectoderm - - - - - - - - - - - - - - - Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. - blastula embryo - blastosphere - blastula - - - - - - - - - - Anatomical entity that has mass. - material anatomical entity - - - - - - - - - - - - - - - - - - - - - Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function. - system - body system - connected anatomical system - organ system - anatomical systems - anatomical system - - - - - - - - - Anatomical structure that is an individual member of a species and consists of more than one cell. - organism - multi-cellular organism - Koerper - body - whole body - whole organism - multicellular organism - - - - - - - - - - Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue. - acellular anatomical structures - acellular anatomical structure - - - - - - - - - Anatomical group that has its parts adjacent to one another. - anatomical cluster - - - - - - - - - - - - - - - Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation. - portion of tissue - tissue portion - simple tissue - tissue - - - - - - - - - - - - - - - - - - - - - - - Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]. - epithelial tissue - portion of epithelium - epithelium - - - - - - - - - Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]. - stratified epithelium - laminated epithelium - multilaminar epithelium - - - - - - - - - Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]. - simple epithelium - unilaminar epithelia - unilaminar epithelium - - - - - - - - - Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. - embryonic organism - developing organism - developmental tissue - embryo - - - - - - - - - A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm. - embryonic tissue - germinal layer - primary germ layer - embryonic germ layer - embryonic germ layers - germ layer - - - - - - - - - - - - - - - - - - - - - Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. - embryonic ectoderm - ectoderm - - - - - - - - - - Functional system which consists of structures involved in respiration. - apparatus respiratorius - respiratory system - Atmungssystem - apparatus respiratorius - systema respiratorium - respiratory system - - - - - - - - - Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. - anatomical entity - - - - - - - - - - - - - - - - - - - - - - - - - - Anatomical structure that is part of an embryo. - developing embryonic structure - embryonic anatomical structure - developing structure - embryonale Struktur - embryonic structures - embryonic structure - - - - - - - - - Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance. - portion of connective tissue - textus connectivus - Bindegewebe - connective tissue - - - - - - - - - - - - - - - - Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle. - integumentary system - body surface - dermal system - external covering of organism - integumentum commune - organism surface - surface - integumental system - - - - - - - - - In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]. - epiblast - blastocyst - ectoblast - epiblastus - primitive ectoderm - epiblast (generic) - - - - - - - - - - - - - - - Anatomical surface structure found in many aquatic organisms. It is a respiration organ whose function is the extraction of oxygen from water and the excretion of carbon dioxide. The microscopic structure of a gill is such that it presents a very large surface area to the external environment. Gills usually consist of thin filaments of tissue, branches, or slender tufted processes which have a highly folded surface to increase surface area. A high surface area is crucial to the gas exchange of aquatic organisms as water contains only 1/20 parts dissolved Oxygen compared to air. With the exception of some aquatic insects, the filaments and lamellae (folds) contain blood or coelomic fluid, from which gases are exchanged through the thin walls. Oxygen is carried by the blood to other parts of the body. Carbon dioxide passes from the blood through the thin gill tissue into the water. Gills or gill-like organs, located in different parts of the body, are found in various groups of aquatic animals, including mollusks, crustaceans, insects, fish, and amphibians. - gill - - - - - - - - - Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism. - anatomical surface feature - surface feature - surface region - surface structures - surface structure - - - - - - - - - - - - - - - - - - - - - - - - - - A portion of connective tissue that is part of a respiratory system [Automatically generated definition]. - apparatus respiratorius connective tissue - apparatus respiratorius portion of connective tissue - apparatus respiratorius textus connectivus - connective tissue of apparatus respiratorius - connective tissue of respiratory system - portion of connective tissue of apparatus respiratorius - portion of connective tissue of respiratory system - respiratory system portion of connective tissue - respiratory system textus connectivus - textus connectivus of apparatus respiratorius - textus connectivus of respiratory system - respiratory system connective tissue - - - - - - - - - - - - - - - - - - - - - - - - - - An anatomical structure that develops (entirely or partially) from the ectoderm. - ectodermal deriviative - ectoderm-derived structure - - - - - - - - - - - - - - - - - - - - - - - - - - An epithelium that is part of a respiratory system [Automatically generated definition]. - apparatus respiratorius epithelial tissue - apparatus respiratorius epithelium - epithelial tissue of apparatus respiratorius - epithelial tissue of respiratory system - epithelium of apparatus respiratorius - epithelium of respiratory system - respiratory system epithelial tissue - respiratory system epithelium - - - - - - - - - - - - - - - - - - - - - - - - - - A portion of tissue that is part of an embryo. - portion of embryonic tissue - developing tissue - embryonic tissue - - - - - - - - - developing structure - developmental structure - developmental tissue - developing anatomical structure - - - - - - - - - - - - - - - An acellular anatomical structure that is the bounding layer of a anatomical structure. - acellular membrane - - - - - - - - - - - - - - - An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina. - basement membrane of connective tissue - membrana basalis - basement membrane - basement membrane of epithelium - - - - - - - - - Portion of embryonic tissue determined by fate mapping to become a structure. - future structure - presumptive structures - presumptive structure + + + A material entity consisting of multiple components that are causally integrated. + May be replaced by a BFO class, as discussed in http://www.jbiomedsem.com/content/4/1/43 + Chris Mungall + http://www.jbiomedsem.com/content/4/1/43 + system - + - - - - - - - - - Presumptive structure of the blastula that will develop into ectoderm. - presumptive epidermis - presumptive ectoderm + + + Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. + biological structure + connected biological structure + anatomical structure - + - - + + - + - A rigid covering that envelops an object. - shell + Anatomical structure that performs a specific function or group of functions [WP]. + anatomical unit + body organ + element + organ - + - - - Organism at the cleavage stage. - cleaving embryo + + + + Anatomical entity that has mass. + material anatomical entity - + - - - + + - - + + - The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]. - epidermis - epidermis (sensu Metazoa) - outer epidermal layer - outer epithelial layer - hypoderm - hypodermis - outer epithelium - - - - - - - - - - - - + + - Outermost layer of cells surrounding the embryo. - EVL - enveloping layer - enveloping layer of ectoderm + Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function. + system + body system + connected anatomical system + organ system + anatomical systems + anatomical system - + - - - An anatomical structure that has more than one cell as a part. - multicellular structure - multicellular anatomical structure + + + Anatomical structure that is an individual member of a species and consists of more than one cell. + organism + multi-cellular organism + animal + Koerper + body + whole body + whole organism + multicellular organism - + - - - + + - - + + - germ layer / neural crest + Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation. + portion of tissue + tissue portion + simple tissue + tissue - + - - - - - - - - - - - - - - - Epithelium composed of cells that develops from the ectoderm[FMA,modified]. - ectoderm-derived epithelium - ecto-epithelium + + + Functional system which consists of structures involved in respiration. + apparatus respiratorius + respiratory system + Atmungssystem + apparatus respiratorius + systema respiratorium + respiratory system - + - - - - - - - - - - - - - + + + Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. + anatomical entity + + + + + + + + - + - A basement membrane of epithelium that is part of a respiratory system. - respiratory system basement membrane + Anatomical surface structure found in many aquatic organisms. It is a respiration organ whose function is the extraction of oxygen from water and the excretion of carbon dioxide. The microscopic structure of a gill is such that it presents a very large surface area to the external environment. Gills usually consist of thin filaments of tissue, branches, or slender tufted processes which have a highly folded surface to increase surface area. A high surface area is crucial to the gas exchange of aquatic organisms as water contains only 1/20 parts dissolved Oxygen compared to air. With the exception of some aquatic insects, the filaments and lamellae (folds) contain blood or coelomic fluid, from which gases are exchanged through the thin walls. Oxygen is carried by the blood to other parts of the body. Carbon dioxide passes from the blood through the thin gill tissue into the water. Gills or gill-like organs, located in different parts of the body, are found in various groups of aquatic animals, including mollusks, crustaceans, insects, fish, and amphibians. + gill - + - - - - - - - - - Material anatomical entity consisting of multiple anatomical structures that are not connected to each other. - disconnected anatomical group + + + An anatomical structure that has more than one cell as a part. + multicellular structure + multicellular anatomical structure @@ -29693,7 +25552,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-05T17:25:21Z Western Australia Ecoregion WWF:AA1310 @@ -29707,7 +25566,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-05T17:51:32Z https://www.worldwildlife.org/biomes/deserts-and-xeric-shrublands Australasia Ecoregion @@ -29720,7 +25579,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-05T17:52:41Z Southern central Australia Ecoregion WWF:AA1309 @@ -29735,7 +25594,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-05T17:54:35Z Eastern central Australia Ecoregion WWF:AA1308 @@ -29750,7 +25609,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-05T17:56:13Z Western Australia Ecoregion WWF:AA1307 @@ -29765,7 +25624,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-05T18:10:52Z Western coast of Australia Ecoregion WWF:AA1301 @@ -29780,7 +25639,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-05T18:12:28Z Central Australia Ecoregion WWF:AA1302 @@ -29795,7 +25654,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-05T18:15:11Z Western central Australia WWF:AA1303 @@ -29810,7 +25669,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-05T18:17:15Z Northwestern Australia WWF:AA1304 @@ -29825,7 +25684,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-05T18:24:06Z Southern Australia Ecoregion WWF:AA1305 @@ -29840,7 +25699,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-05T18:26:16Z Southern Australia Ecoregion WWF:AA1306 @@ -29854,7 +25713,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:01:41Z https://www.worldwildlife.org/biomes/deserts-and-xeric-shrublands Afrotropical Ecoregion @@ -29867,7 +25726,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:02:37Z Southern Africa: Southern Namibia into South Africa WWF:AT1322 @@ -29882,7 +25741,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:07:38Z WWF:AT1321 https://www.worldwildlife.org/ecoregions/at1321 @@ -29897,7 +25756,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:11:38Z WWF:AT1320 https://www.worldwildlife.org/ecoregions/at1320 @@ -29912,7 +25771,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:13:00Z WWF:AT1319 https://www.worldwildlife.org/ecoregions/at1319 @@ -29927,7 +25786,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:15:07Z Islands east of the Horn of Africa and south of Yemen Ecoregion WWF:AT1318 @@ -29942,7 +25801,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:18:55Z WWF:AT1317 https://www.worldwildlife.org/ecoregions/at1317 @@ -29956,7 +25815,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:20:56Z WWF:AT1316 https://www.worldwildlife.org/ecoregions/at1316 @@ -29970,7 +25829,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:24:28Z Africa: Namibia Ecoregion WWF:AT1315 @@ -29985,7 +25844,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:26:15Z WWF:AT1314 https://www.worldwildlife.org/ecoregions/at1314 @@ -29999,7 +25858,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:28:43Z WWF:AT1313 https://www.worldwildlife.org/ecoregions/at1313 @@ -30013,7 +25872,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:30:23Z WWF:AT1312 https://www.worldwildlife.org/ecoregions/at1312 @@ -30027,7 +25886,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:31:29Z WWF:AT1311 https://www.worldwildlife.org/ecoregions/at1311 @@ -30042,7 +25901,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:39:32Z WWF:AT1310 https://www.worldwildlife.org/ecoregions/at1310 @@ -30057,7 +25916,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:42:47Z WWF:AT1309 https://www.worldwildlife.org/ecoregions/at1309 @@ -30071,7 +25930,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:44:54Z WWF:AT1308 https://www.worldwildlife.org/ecoregions/at1308 @@ -30086,7 +25945,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:46:58Z Eastern Africa: Somalia WWF:AT1307 @@ -30101,7 +25960,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-06T22:54:57Z WWF:AT1306 https://www.worldwildlife.org/ecoregions/at1306 @@ -30116,7 +25975,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-07T00:08:06Z WWF:AT1305 https://www.worldwildlife.org/ecoregions/at1305 @@ -30130,7 +25989,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-07T00:11:29Z WWF:AT1304 https://www.worldwildlife.org/ecoregions/at1304 @@ -30144,7 +26003,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-07T00:13:33Z WWF:AT1303 https://www.worldwildlife.org/ecoregions/at1303 @@ -30159,7 +26018,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-07T00:16:12Z WWF:AT1302 https://www.worldwildlife.org/ecoregions/at1302 @@ -30174,7 +26033,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-03-07T00:18:09Z WWF:AT1301 https://www.worldwildlife.org/ecoregions/at1301 @@ -30187,7 +26046,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-04-26T23:38:50Z Indo-Malay Ecoregion @@ -30201,7 +26060,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-04-26T23:40:13Z WWF:IM1304 @@ -30216,7 +26075,7 @@ Classes for population already exist in IDO ('organism population', I - + 2019-04-27T00:12:51Z WWF:IM1303 @@ -30231,7 +26090,7 @@ Classes for population already exist in IDO ('organism population', I A polar front between the deep, cold Arctic air and the shallower, warmer polar air of northern latitudes on Earth. - + 2019-08-20T13:47:18Z envoAtmo envoPolar @@ -30251,7 +26110,7 @@ Classes for population already exist in IDO ('organism population', I A polar front between the deep, cold Antarctic air and the shallower, warmer polar air of southern latitudes on Earth. - + 2019-08-20T13:48:44Z envoAtmo envoPolar @@ -30272,7 +26131,7 @@ Classes for population already exist in IDO ('organism population', I Stellar radiation emitted from Sol. - + 2020-05-19T22:27:44Z Solar radiation @@ -30330,39 +26189,6 @@ Classes for population already exist in IDO ('organism population', I /////////////////////////////////////////////////////////////////////////////////////// --> - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - @@ -30371,1370 +26197,6 @@ Classes for population already exist in IDO ('organism population', I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - true - MF(X)-directly_regulates->MF(Y)-enabled_by->GP(Z) => MF(Y)-has_input->GP(Y) e.g. if 'protein kinase activity'(X) directly_regulates 'protein binding activity (Y)and this is enabled by GP(Z) then X has_input Z - infer input from direct reg - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - GP(X)-enables->MF(Y)-has_part->MF(Z) => GP(X) enables MF(Z), -e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase coupled transporter activity' has_part 'ATPase activity' then GP(X) enables 'ATPase activity' - enabling an MF enables its parts - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - true - GP(X)-enables->MF(Y)-part_of->BP(Z) => GP(X) involved_in BP(Z) e.g. if X enables 'protein kinase activity' and Y 'part of' 'signal tranduction' then X involved in 'signal transduction' - involved in BP - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - If a molecular function (X) has a regulatory subfunction, then any gene product which is an input to that subfunction has an activity that directly_regulates X. Note: this is intended for cases where the regaultory subfunction is protein binding, so it could be tightened with an additional clause to specify this. - inferring direct reg edge from input to regulatory subfunction - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - inferring direct neg reg edge from input to regulatory subfunction - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - inferring direct positive reg edge from input to regulatory subfunction - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - effector input is compound function input - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Input of effector is input of its parent MF - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - if effector directly regulates X, its parent MF directly regulates X - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - if effector directly positively regulates X, its parent MF directly positively regulates X - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - if effector directly negatively regulates X, its parent MF directly negatively regulates X - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 'causally downstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 'causally upstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - diff --git a/src/ontology/imports/go_import.owl b/src/ontology/imports/go_import.owl index a5b4449..a85945a 100644 --- a/src/ontology/imports/go_import.owl +++ b/src/ontology/imports/go_import.owl @@ -9,12 +9,11 @@ xmlns:xml="http://www.w3.org/XML/1998/namespace" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" - xmlns:terms="http://purl.org/dc/terms/" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - - 2023-12-18 + + + 2022-10-05 @@ -164,24 +163,6 @@ - - - - - - - - - - - - - - - - - - @@ -361,8 +342,7 @@ - A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). - https://github.com/geneontology/go-ontology/issues/17729 + A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome). GO:0008372 NIF_Subcellular:sao1337158144 cell or subcellular entity @@ -376,14 +356,15 @@ - Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. + Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. cellular_component - A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). + A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome). GOC:pdt + NIF_Subcellular:sao1337158144 @@ -418,19 +399,19 @@ A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. - ISBN:0198506732 + ISBN:0198506732 nucleocytoplasm - GOC:mah + GOC:mah protoplast - GOC:mah + GOC:mah @@ -456,47 +437,14 @@ - Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. + Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. - ISBN:0198547684 - - - - - - - - - - - - - - - The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. - https://github.com/geneontology/go-ontology/issues/23023 - Wikipedia:Cytoplasm - cellular_component - GO:0005737 - - - - - - - - cytoplasm - - - - - The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. - ISBN:0198547684 + ISBN:0198547684 @@ -524,16 +472,16 @@ - - Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. - GOC:ai + + nucleobase, nucleoside, nucleotide and nucleic acid metabolic process + GOC:dph + GOC:tb - - nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - GOC:dph - GOC:tb + + Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. + GOC:ai @@ -541,6 +489,7 @@ + Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. GO:0055132 @@ -561,7 +510,7 @@ Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. - ISBN:0198506732 + ISBN:0198506732 @@ -607,7 +556,7 @@ - + @@ -624,7 +573,7 @@ Any process that modulates the frequency, rate or extent of DNA repair. - GOC:go_curators + GOC:go_curators @@ -646,8 +595,8 @@ The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. - GOC:ai - ISBN:0198506732 + GOC:ai + ISBN:0198506732 @@ -668,8 +617,8 @@ The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. - GOC:jl - ISBN:0198506732 + GOC:jl + ISBN:0198506732 @@ -696,7 +645,7 @@ Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). - GOC:mah + GOC:mah @@ -706,22 +655,21 @@ Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. - https://github.com/geneontology/go-ontology/issues/24775 GO:0034984 response to DNA damage stimulus + DNA damage response cellular DNA damage response - cellular response to DNA damage stimulus response to genotoxic stress biological_process GO:0006974 - DNA damage response + cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. - GOC:go_curators + GOC:go_curators @@ -729,8 +677,7 @@ - A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. - https://github.com/geneontology/go-ontology/issues/24968 + A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. jl 2012-09-19T15:05:24Z GO:0000004 @@ -750,13 +697,13 @@ - Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. + Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. biological_process - A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. + A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. GOC:pdt @@ -791,8 +738,8 @@ The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. - GOC:go_curators - ISBN:0198547684 + GOC:go_curators + ISBN:0198547684 @@ -813,7 +760,7 @@ Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. - GOC:jl + GOC:jl Wikipedia:Electromagnetic_radiation @@ -838,7 +785,7 @@ Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. - GOC:hb + GOC:hb @@ -883,7 +830,7 @@ Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - GOC:go_curators + GOC:go_curators @@ -930,7 +877,7 @@ Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - GOC:go_curators + GOC:go_curators @@ -953,15 +900,14 @@ GO:0009987 - This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GOC:go_curators - GOC:isa_complete + GOC:go_curators + GOC:isa_complete @@ -980,7 +926,7 @@ Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). - GOC:sm + GOC:sm Wikipedia:X-ray @@ -1021,7 +967,7 @@ Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. - GOC:tair_curators + GOC:tair_curators @@ -1057,8 +1003,8 @@ Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:dph - GOC:tb + GOC:dph + GOC:tb @@ -1094,8 +1040,8 @@ Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:dph - GOC:tb + GOC:dph + GOC:tb @@ -1134,14 +1080,14 @@ Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. - GOC:go_curators + GOC:go_curators regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - GOC:dph - GOC:tb + GOC:dph + GOC:tb @@ -1181,13 +1127,13 @@ Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - GOC:go_curators + GOC:go_curators regulation of organismal metabolic process - GOC:tb + GOC:tb @@ -1225,7 +1171,7 @@ Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. - GOC:mah + GOC:mah @@ -1268,7 +1214,7 @@ Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. - GOC:mah + GOC:mah @@ -1312,7 +1258,7 @@ Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. - GOC:mah + GOC:mah @@ -1333,7 +1279,7 @@ Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). - GOC:mah + GOC:mah @@ -1354,7 +1300,7 @@ The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells. - GOC:mah + GOC:mah @@ -1379,9 +1325,9 @@ A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. - GOC:bf - GOC:mah - GOC:vw + GOC:bf + GOC:mah + GOC:vw PMID:20096808 PMID:21035408 @@ -1395,13 +1341,13 @@ DNA damage foci - GOC:vw + GOC:vw DNA damage focus - GOC:mah + GOC:mah PMID:20096808 PMID:21035408 @@ -1427,7 +1373,6 @@ The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GO:0034960 GO:0043283 GO:0044259 biopolymer metabolic process @@ -1443,7 +1388,7 @@ The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:mah + GOC:mah @@ -1473,7 +1418,7 @@ Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. - GOC:go_curators + GOC:go_curators @@ -1486,8 +1431,8 @@ https://github.com/geneontology/go-ontology/issues/21881 NIF_Subcellular:sao1456184038 non-membrane-enclosed organelle + biological condensate cellular_component - biological condensate GO:0043228 non-membrane-bounded organelle @@ -1496,7 +1441,7 @@ Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. - GOC:go_curators + GOC:go_curators @@ -1532,7 +1477,7 @@ Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. - GOC:go_curators + GOC:go_curators @@ -1564,7 +1509,7 @@ Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. - GOC:go_curators + GOC:go_curators @@ -1580,20 +1525,19 @@ intermediary metabolism GO:0044237 - This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. - GOC:go_curators + GOC:go_curators intermediary metabolism - GOC:mah + GOC:mah @@ -1613,12 +1557,40 @@ The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. - GOC:go_curators + GOC:go_curators http://www.metacyc.org + + + + + + The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. + GO:0034960 + cellular biopolymer metabolic process + cellular macromolecule metabolism + biological_process + GO:0044260 + cellular macromolecule metabolic process + + + + + The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. + GOC:mah + + + + + cellular biopolymer metabolic process + GOC:mtg_chebi_dec09 + + + + @@ -1634,8 +1606,8 @@ - + @@ -1655,7 +1627,7 @@ Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair. - GOC:go_curators + GOC:go_curators @@ -1675,8 +1647,8 @@ - + @@ -1697,7 +1669,7 @@ Any process that activates or increases the frequency, rate or extent of DNA repair. - GOC:go_curators + GOC:go_curators @@ -1740,14 +1712,14 @@ Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. - GOC:go_curators + GOC:go_curators negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - GOC:dph - GOC:tb + GOC:dph + GOC:tb @@ -1791,14 +1763,14 @@ Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. - GOC:go_curators + GOC:go_curators positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - GOC:dph - GOC:tb + GOC:dph + GOC:tb @@ -1818,7 +1790,7 @@ The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). - ISBN:0198506732 + ISBN:0198506732 @@ -1861,7 +1833,7 @@ Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - GOC:jid + GOC:jid @@ -1903,7 +1875,7 @@ Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - GOC:jid + GOC:jid @@ -1947,7 +1919,7 @@ Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GOC:jid + GOC:jid @@ -1990,7 +1962,7 @@ Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GOC:jid + GOC:jid @@ -2027,7 +1999,7 @@ Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. - GOC:jid + GOC:jid @@ -2070,7 +2042,7 @@ Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. - GOC:jid + GOC:jid @@ -2112,7 +2084,7 @@ Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. - GOC:jid + GOC:jid @@ -2152,8 +2124,8 @@ Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - GOC:ai - GOC:go_curators + GOC:ai + GOC:go_curators @@ -2191,7 +2163,7 @@ Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GOC:go_curators + GOC:go_curators @@ -2218,8 +2190,8 @@ Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. - GOC:ai - GOC:bf + GOC:ai + GOC:bf @@ -2257,7 +2229,7 @@ Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. - GOC:ai + GOC:ai @@ -2299,7 +2271,7 @@ Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. - GOC:ai + GOC:ai @@ -2342,7 +2314,7 @@ Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. - GOC:ai + GOC:ai @@ -2379,14 +2351,14 @@ Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. - GOC:ai - GOC:tb + GOC:ai + GOC:tb regulation of nitrogen metabolic process - GOC:tb + GOC:tb @@ -2428,14 +2400,14 @@ Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. - GOC:ai - GOC:tb + GOC:ai + GOC:tb negative regulation of nitrogen metabolic process - GOC:tb + GOC:tb @@ -2478,14 +2450,14 @@ Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. - GOC:ai - GOC:tb + GOC:ai + GOC:tb positive regulation of nitrogen metabolic process - GOC:tb + GOC:tb @@ -2506,8 +2478,8 @@ Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. - GOC:bf - GOC:jl + GOC:bf + GOC:jl @@ -2542,8 +2514,8 @@ Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:dph - GOC:tb + GOC:dph + GOC:tb @@ -2564,11 +2536,11 @@ Any process that modulates a measurable attribute of any biological process, quality or function. - GOC:dph - GOC:isa_complete - GOC:mah - GOC:pr - GOC:vw + GOC:dph + GOC:isa_complete + GOC:mah + GOC:pr + GOC:vw @@ -2592,13 +2564,13 @@ Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. - GOC:mah + GOC:mah cellular response to abiotic stress - GOC:mah + GOC:mah @@ -2622,19 +2594,19 @@ Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. - GOC:mah + GOC:mah cellular response to electromagnetic radiation stimulus - GOC:mah + GOC:mah cellular response to radiation stimulus - GOC:mah + GOC:mah @@ -2657,19 +2629,19 @@ Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. - GOC:mah + GOC:mah cellular response to ionising radiation - GOC:mah + GOC:mah cellular response to ionizing radiation stimulus - GOC:mah + GOC:mah @@ -2692,19 +2664,19 @@ Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. - GOC:mah + GOC:mah cellular response to gamma ray - GOC:mah + GOC:mah cellular response to gamma-ray photon - GOC:mah + GOC:mah @@ -2726,13 +2698,13 @@ Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). - GOC:mah + GOC:mah cellular response to X-ray radiation stimulus - GOC:mah + GOC:mah @@ -2755,7 +2727,7 @@ The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. - GOC:mah + GOC:mah @@ -2880,7 +2852,6 @@ Any cellular metabolic process involving nucleic acids. - https://github.com/geneontology/go-ontology/issues/26133 tb 2010-04-07T10:18:47Z biological_process @@ -2891,8 +2862,8 @@ Any cellular metabolic process involving nucleic acids. - GOC:dph - GOC:tb + GOC:dph + GOC:tb @@ -2919,43 +2890,7 @@ A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. - GOC:pg - - - - - - - - - - - - - - - - - - - - - - - - - - Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. - cellular_component - GO:0099568 - - cytoplasmic region - - - - - Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. - GOC:dos + GOC:pg @@ -2975,7 +2910,7 @@ Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus. - GOC:dos + GOC:dos @@ -2985,20 +2920,17 @@ A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. - https://github.com/geneontology/go-ontology/issues/24200 kmv 2019-08-12T18:01:37Z cellular_component GO:0110165 - - cellular anatomical entity A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. - GOC:kmv + GOC:kmv @@ -3019,13 +2951,13 @@ The chemical reactions and pathways involving organic cyclic compound. - GOC:TermGenie + GOC:TermGenie organic cyclic compound metabolism - GOC:TermGenie + GOC:TermGenie @@ -3065,21 +2997,21 @@ Any process that modulates the frequency, rate or extent of cellular response to gamma radiation. - GOC:TermGenie - GO_REF:0000058 + GOC:TermGenie + GO_REF:0000058 PMID:23505386 regulation of cellular response to gamma ray - GOC:TermGenie + GOC:TermGenie regulation of cellular response to gamma-ray photon - GOC:TermGenie + GOC:TermGenie @@ -3132,93 +3064,93 @@ Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to gamma radiation. - GOC:TermGenie - GO_REF:0000058 + GOC:TermGenie + GO_REF:0000058 PMID:23505386 down regulation of cellular response to gamma radiation - GOC:TermGenie + GOC:TermGenie down-regulation of cellular response to gamma radiation - GOC:TermGenie + GOC:TermGenie downregulation of cellular response to gamma radiation - GOC:TermGenie + GOC:TermGenie inhibition of cellular response to gamma radiation - GOC:TermGenie + GOC:TermGenie down regulation of cellular response to gamma ray - GOC:TermGenie + GOC:TermGenie down regulation of cellular response to gamma-ray photon - GOC:TermGenie + GOC:TermGenie down-regulation of cellular response to gamma ray - GOC:TermGenie + GOC:TermGenie down-regulation of cellular response to gamma-ray photon - GOC:TermGenie + GOC:TermGenie downregulation of cellular response to gamma ray - GOC:TermGenie + GOC:TermGenie downregulation of cellular response to gamma-ray photon - GOC:TermGenie + GOC:TermGenie inhibition of cellular response to gamma ray - GOC:TermGenie + GOC:TermGenie inhibition of cellular response to gamma-ray photon - GOC:TermGenie + GOC:TermGenie negative regulation of cellular response to gamma ray - GOC:TermGenie + GOC:TermGenie negative regulation of cellular response to gamma-ray photon - GOC:TermGenie + GOC:TermGenie @@ -3271,93 +3203,93 @@ Any process that activates or increases the frequency, rate or extent of cellular response to gamma radiation. - GOC:TermGenie - GO_REF:0000058 + GOC:TermGenie + GO_REF:0000058 PMID:23505386 up regulation of cellular response to gamma radiation - GOC:TermGenie + GOC:TermGenie up-regulation of cellular response to gamma radiation - GOC:TermGenie + GOC:TermGenie upregulation of cellular response to gamma radiation - GOC:TermGenie + GOC:TermGenie activation of cellular response to gamma radiation - GOC:TermGenie + GOC:TermGenie activation of cellular response to gamma ray - GOC:TermGenie + GOC:TermGenie activation of cellular response to gamma-ray photon - GOC:TermGenie + GOC:TermGenie positive regulation of cellular response to gamma ray - GOC:TermGenie + GOC:TermGenie positive regulation of cellular response to gamma-ray photon - GOC:TermGenie + GOC:TermGenie up regulation of cellular response to gamma ray - GOC:TermGenie + GOC:TermGenie up regulation of cellular response to gamma-ray photon - GOC:TermGenie + GOC:TermGenie up-regulation of cellular response to gamma ray - GOC:TermGenie + GOC:TermGenie up-regulation of cellular response to gamma-ray photon - GOC:TermGenie + GOC:TermGenie upregulation of cellular response to gamma ray - GOC:TermGenie + GOC:TermGenie upregulation of cellular response to gamma-ray photon - GOC:TermGenie + GOC:TermGenie @@ -3396,13 +3328,13 @@ Any process that modulates the frequency, rate or extent of cellular response to X-ray. - GOC:obol + GOC:obol regulation of cellular response to X-ray radiation stimulus - GOC:obol + GOC:obol @@ -3442,13 +3374,13 @@ Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to X-ray. - GOC:obol + GOC:obol negative regulation of cellular response to X-ray radiation stimulus - GOC:obol + GOC:obol @@ -3488,13 +3420,212 @@ Any process that activates or increases the frequency, rate or extent of cellular response to X-ray. - GOC:obol + GOC:obol positive regulation of cellular response to X-ray radiation stimulus - GOC:obol + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of response to DNA damage stimulus. + yaf + 2011-08-19T10:20:25Z + regulation of DNA damage response + regulation of cellular DNA damage response + regulation of cellular response to DNA damage stimulus + regulation of response to genotoxic stress + biological_process + GO:2001020 + regulation of response to DNA damage stimulus + + + + + Any process that modulates the frequency, rate or extent of response to DNA damage stimulus. + GOC:obol + + + + + regulation of DNA damage response + GOC:obol + + + + + regulation of cellular DNA damage response + GOC:obol + + + + + regulation of cellular response to DNA damage stimulus + GOC:obol + + + + + regulation of response to genotoxic stress + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus. + yaf + 2011-08-19T10:20:29Z + negative regulation of DNA damage response + negative regulation of cellular DNA damage response + negative regulation of cellular response to DNA damage stimulus + negative regulation of response to genotoxic stress + biological_process + GO:2001021 + negative regulation of response to DNA damage stimulus + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus. + GOC:obol + + + + + negative regulation of DNA damage response + GOC:obol + + + + + negative regulation of cellular DNA damage response + GOC:obol + + + + + negative regulation of cellular response to DNA damage stimulus + GOC:obol + + + + + negative regulation of response to genotoxic stress + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus. + yaf + 2011-08-19T10:20:33Z + positive regulation of DNA damage response + positive regulation of cellular DNA damage response + positive regulation of cellular response to DNA damage stimulus + positive regulation of response to genotoxic stress + biological_process + GO:2001022 + positive regulation of response to DNA damage stimulus + + + + + Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus. + GOC:obol + + + + + positive regulation of DNA damage response + GOC:obol + + + + + positive regulation of cellular DNA damage response + GOC:obol + + + + + positive regulation of cellular response to DNA damage stimulus + GOC:obol + + + + + positive regulation of response to genotoxic stress + GOC:obol @@ -3533,19 +3664,19 @@ Any process that modulates the frequency, rate or extent of response to gamma radiation. - GOC:obol + GOC:obol regulation of response to gamma ray - GOC:obol + GOC:obol regulation of response to gamma-ray photon - GOC:obol + GOC:obol @@ -3585,19 +3716,19 @@ Any process that stops, prevents or reduces the frequency, rate or extent of response to gamma radiation. - GOC:obol + GOC:obol negative regulation of response to gamma ray - GOC:obol + GOC:obol negative regulation of response to gamma-ray photon - GOC:obol + GOC:obol @@ -3637,19 +3768,19 @@ Any process that activates or increases the frequency, rate or extent of response to gamma radiation. - GOC:obol + GOC:obol positive regulation of response to gamma ray - GOC:obol + GOC:obol positive regulation of response to gamma-ray photon - GOC:obol + GOC:obol diff --git a/src/ontology/imports/go_top.tmp.owl b/src/ontology/imports/go_top.tmp.owl index 843d05e..25f296c 100644 --- a/src/ontology/imports/go_top.tmp.owl +++ b/src/ontology/imports/go_top.tmp.owl @@ -165,7 +165,7 @@ A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis. - GOC:elh + GOC:elh PMID:10357855 @@ -185,7 +185,7 @@ The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines. - GOC:elh + GOC:elh PMID:10915863 @@ -206,7 +206,7 @@ The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. - GOC:elh + GOC:elh @@ -232,26 +232,26 @@ The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. - GOC:elh + GOC:elh PMID:10357855 HDR - GOC:vk + GOC:vk Rad51-dependent recombinational repair - GOC:mah + GOC:mah homology-directed repair - GOC:vk + GOC:vk @@ -270,7 +270,7 @@ A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region. - GOC:elh + GOC:elh @@ -288,7 +288,7 @@ The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome. - GOC:elh + GOC:elh PMID:10357855 @@ -335,33 +335,33 @@ The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. - PMID:10197977 + PMID:10197977 PMID:11900249 TC-NER - PMID:10197977 + PMID:10197977 transcription-coupled NER - GOC:mah + GOC:mah transcription-coupled repair - GOC:vw + GOC:vw PMID:18794354 TCR - GOC:vw + GOC:vw PMID:18794354 @@ -382,7 +382,7 @@ In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. - ISBN:0815316194 + ISBN:0815316194 @@ -405,7 +405,7 @@ A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). - PMID:10197977 + PMID:10197977 @@ -423,7 +423,7 @@ The repair of UV-induced T-T, C-T and C-C dimers. - ISBN:0815316194 + ISBN:0815316194 @@ -447,7 +447,7 @@ A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. - ISBN:0198506732 + ISBN:0198506732 PMID:11687886 @@ -468,7 +468,7 @@ The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication. - GOC:elh + GOC:elh @@ -487,7 +487,7 @@ The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. - GOC:elh + GOC:elh @@ -506,7 +506,7 @@ The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. - GOC:rph + GOC:rph PMID:10827453 PMID:24837021 @@ -551,8 +551,8 @@ A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another. - GOC:dph - GOC:tb + GOC:dph + GOC:tb @@ -570,8 +570,8 @@ A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. - GOC:dph - GOC:tb + GOC:dph + GOC:tb @@ -590,15 +590,15 @@ The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide. - GOC:elh - GOC:vw + GOC:elh + GOC:vw PMID:10535901 bypass DNA synthesis - GOC:elh + GOC:elh @@ -619,7 +619,7 @@ Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. - GOC:vw + GOC:vw PMID:16464006 PMID:22064477 @@ -642,7 +642,6 @@ 2012-08-07T11:11:59Z recombination-dependent interstrand cross-link repair biological_process - Fanconi pathway GO:0036298 recombinational interstrand cross-link repair @@ -650,20 +649,14 @@ Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region. - GOC:vw + GOC:vw PMID:20658649 recombination-dependent interstrand cross-link repair - GOC:vw - - - - - Fanconi pathway - PMID:31563844 + GOC:vw @@ -685,7 +678,7 @@ Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that does not involve homologous DNA recombination. - GOC:vw + GOC:vw PMID:11154259 PMID:22064477 @@ -693,13 +686,13 @@ recombination-independent ICL repair - GOC:vw + GOC:vw recombination-independent interstrand cross-link repair - GOC:vw + GOC:vw @@ -720,8 +713,8 @@ The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions but does not increase the endogenous mutation rate. - GOC:elh - GOC:jl + GOC:elh + GOC:jl PMID:11459630 @@ -743,21 +736,21 @@ The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. - GOC:elh - GOC:jl + GOC:elh + GOC:jl PMID:11485998 error-prone postreplication DNA repair - GOC:elh + GOC:elh mutagenic postreplication DNA repair - GOC:elh + GOC:elh @@ -833,7 +826,7 @@ Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity. - GOC:ai + GOC:ai @@ -872,15 +865,15 @@ A mismatch repair process that corrects errors introduced that ensures the accuracy of DNA replication. - GOC:BHF - GOC:mah + GOC:BHF + GOC:mah mismatch repair involved in maintenance of fidelity during DNA-dependent DNA replication - GOC:dph - GOC:tb + GOC:dph + GOC:tb @@ -905,40 +898,40 @@ The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome. - PMID:10197977 + PMID:10197977 PMID:18794354 GG-NER - PMID:10197977 + PMID:10197977 GGR - GOC:vw + GOC:vw PMID:18794354 global genome NER - GOC:mah + GOC:mah global genomic nucleotide-excision repair - GOC:mah - GOC:vw + GOC:mah + GOC:vw global genomic repair - GOC:vw + GOC:vw PMID:18794354 @@ -964,41 +957,41 @@ A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs). - GOC:mah + GOC:mah PMID:9619100 UV-damaged DNA endonuclease-dependent excision repair - GOC:vw + GOC:vw UVDE-dependent excision repair - GOC:vw + GOC:vw PMID:9619100 UVER - GOC:vw + GOC:vw PMID:9619100 AER - GOC:mah + GOC:mah PMID:10704216 alternative excision repair - GOC:mah + GOC:mah PMID:10704216 @@ -1020,7 +1013,7 @@ The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level. - GOC:elh + GOC:elh @@ -1042,7 +1035,7 @@ The repair of double-strand breaks in mitochondrial DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. - GOC:di + GOC:di PMID:22214610 @@ -1066,7 +1059,7 @@ The repair of a double-strand break in mitochondrial DNA in which the broken DNA molecule is repaired using homologous sequences. - GOC:di + GOC:di PMID:22214610 @@ -1089,7 +1082,7 @@ An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining). - GOC:rph + GOC:rph PMID:18584027 @@ -1114,7 +1107,7 @@ An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment. - GOC:rph + GOC:rph PMID:18584027 PMID:21655080 Wikipedia:Microhomology-mediated_end_joining @@ -1137,8 +1130,8 @@ A telomere maintenance process that occurs by base-excision repair of telomeric DNA in response to DNA damage. Telomeric sequences are particularly susceptible to oxidative DNA damage, due to their G-rich nature. - GOC:BHF - GOC:BHF_telomere + GOC:BHF + GOC:BHF_telomere GOC:jbu PMID:24703901 @@ -1204,26 +1197,26 @@ Any nucleotide-excision repair that is involved in interstrand cross-link repair. - GOC:TermGenie + GOC:TermGenie PMID:22064477 NER involved in ICL repair - GOC:TermGenie + GOC:TermGenie NER involved in interstrand cross-link repair - GOC:TermGenie + GOC:TermGenie nucleotide-excision repair involved in ICL repair - GOC:TermGenie + GOC:TermGenie @@ -1247,7 +1240,7 @@ Single strand break repair that takes place in a telomere. - GOC:TermGenie + GOC:TermGenie GO_REF:0000062 PMID:24374808 @@ -1255,7 +1248,7 @@ single strand break repair in telomere - GOC:TermGenie + GOC:TermGenie @@ -1277,7 +1270,7 @@ The error-free repair of a single-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. - GOC:bhm + GOC:bhm PMID:24339919 @@ -1299,7 +1292,7 @@ The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks. - GOC:rb + GOC:rb PMID:12820977 PMID:16888651 @@ -1342,7 +1335,7 @@ The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination. - GOC:mah + GOC:mah PMID:15238514 diff --git a/src/ontology/imports/ncbitaxon_import.owl b/src/ontology/imports/ncbitaxon_import.owl index cdd7312..4f26444 100644 --- a/src/ontology/imports/ncbitaxon_import.owl +++ b/src/ontology/imports/ncbitaxon_import.owl @@ -7,12 +7,11 @@ xmlns:xml="http://www.w3.org/XML/1998/namespace" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" - xmlns:terms="http://purl.org/dc/terms/" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#" xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#"> - - 2023-12-18 + + 2022-10-06 @@ -31,7 +30,7 @@ - definition + definition @@ -42,12 +41,6 @@ - - - - - - @@ -57,7 +50,7 @@ - has_broad_synonym + has_broad_synonym @@ -65,7 +58,7 @@ - database_cross_reference + database_cross_reference @@ -73,7 +66,7 @@ - has_exact_synonym + has_exact_synonym @@ -110,17 +103,15 @@ - GC_ID:1 - PMID:30365038 - PMID:32761142 - ncbi_taxonomy - all - root + GC_ID:1 + ncbi_taxonomy + all + root - all + all @@ -131,15 +122,15 @@ - GC_ID:1 - hamsters - ncbi_taxonomy - Cricetinae + GC_ID:1 + hamsters + ncbi_taxonomy + Cricetinae - hamsters + hamsters @@ -150,9 +141,9 @@ - GC_ID:1 - ncbi_taxonomy - Mesocricetus + GC_ID:1 + ncbi_taxonomy + Mesocricetus @@ -162,10 +153,10 @@ - GC_ID:1 - PMID:15371245 - ncbi_taxonomy - Muridae + GC_ID:1 + PMID:15371245 + ncbi_taxonomy + Muridae @@ -175,23 +166,23 @@ - GC_ID:1 - rat - rats - ncbi_taxonomy - Rattus + GC_ID:1 + rat + rats + ncbi_taxonomy + Rattus - rat - + rat + - rats - + rats + @@ -201,9 +192,9 @@ - GC_ID:1 - ncbi_taxonomy - Obtectomera + GC_ID:1 + ncbi_taxonomy + Obtectomera @@ -213,16 +204,16 @@ - NCBITaxon:1537974 - GC_ID:1 - ncbi_taxonomy - Allolobophorinae - Lumbricinae + NCBITaxon:1537974 + GC_ID:1 + ncbi_taxonomy + Allolobophorinae + Lumbricinae - Allolobophorinae + Allolobophorinae @@ -232,9 +223,9 @@ - GC_ID:1 - ncbi_taxonomy - Lumbricus terrestris complex + GC_ID:1 + ncbi_taxonomy + Lumbricus terrestris complex @@ -243,9 +234,9 @@ - GC_ID:1 - ncbi_taxonomy - Lumbricus rubellus complex + GC_ID:1 + ncbi_taxonomy + Lumbricus rubellus complex @@ -255,9 +246,9 @@ - GC_ID:1 - ncbi_taxonomy - Xenoturbellida + GC_ID:1 + ncbi_taxonomy + Xenoturbellida @@ -267,9 +258,9 @@ - GC_ID:1 - ncbi_taxonomy - Xenoturbella + GC_ID:1 + ncbi_taxonomy + Xenoturbella @@ -279,9 +270,9 @@ - GC_ID:1 - ncbi_taxonomy - Sarsostraca + GC_ID:1 + ncbi_taxonomy + Sarsostraca @@ -291,9 +282,9 @@ - GC_ID:1 - ncbi_taxonomy - Phyllopoda + GC_ID:1 + ncbi_taxonomy + Phyllopoda @@ -303,9 +294,9 @@ - GC_ID:1 - ncbi_taxonomy - Anomopoda + GC_ID:1 + ncbi_taxonomy + Anomopoda @@ -314,10 +305,10 @@ - NCBITaxon:6795 - GC_ID:1 - ncbi_taxonomy - Eubrachyura + NCBITaxon:6795 + GC_ID:1 + ncbi_taxonomy + Eubrachyura @@ -326,18 +317,18 @@ - NCBITaxon:29963 - NCBITaxon:6773 - NCBITaxon:6803 - GC_ID:1 - ncbi_taxonomy - Brachyrhyncha - Heterotremata + NCBITaxon:29963 + NCBITaxon:6773 + NCBITaxon:6803 + GC_ID:1 + ncbi_taxonomy + Brachyrhyncha + Heterotremata - Brachyrhyncha + Brachyrhyncha @@ -348,9 +339,9 @@ - GC_ID:1 - ncbi_taxonomy - Teleostomi + GC_ID:1 + ncbi_taxonomy + Teleostomi @@ -360,16 +351,16 @@ - NCBITaxon:40673 - GC_ID:1 - bony vertebrates - ncbi_taxonomy - Euteleostomi + NCBITaxon:40673 + GC_ID:1 + bony vertebrates + ncbi_taxonomy + Euteleostomi - bony vertebrates + bony vertebrates @@ -380,16 +371,16 @@ - NCBITaxon:27837 - GC_ID:1 - ncbi_taxonomy - Adenophorea - Chromadorea + NCBITaxon:27837 + GC_ID:1 + ncbi_taxonomy + Adenophorea + Chromadorea - Adenophorea + Adenophorea @@ -400,9 +391,9 @@ - GC_ID:1 - ncbi_taxonomy - Ecdysozoa + GC_ID:1 + ncbi_taxonomy + Ecdysozoa @@ -412,9 +403,9 @@ - GC_ID:1 - ncbi_taxonomy - Lophotrochozoa + GC_ID:1 + ncbi_taxonomy + Lophotrochozoa @@ -424,9 +415,9 @@ - GC_ID:1 - ncbi_taxonomy - Neoteleostei + GC_ID:1 + ncbi_taxonomy + Neoteleostei @@ -436,15 +427,15 @@ - GC_ID:1 - ncbi_taxonomy - Eurypterygii - Eurypterygia + GC_ID:1 + ncbi_taxonomy + Eurypterygii + Eurypterygia - Eurypterygii + Eurypterygii @@ -455,9 +446,9 @@ - GC_ID:1 - ncbi_taxonomy - Ctenosquamata + GC_ID:1 + ncbi_taxonomy + Ctenosquamata @@ -467,15 +458,15 @@ - GC_ID:1 - ncbi_taxonomy - Acanthomorpha - Acanthomorphata + GC_ID:1 + ncbi_taxonomy + Acanthomorpha + Acanthomorphata - Acanthomorpha + Acanthomorpha @@ -486,15 +477,15 @@ - GC_ID:1 - ncbi_taxonomy - Euacanthomorpha - Euacanthomorphacea + GC_ID:1 + ncbi_taxonomy + Euacanthomorpha + Euacanthomorphacea - Euacanthomorpha + Euacanthomorpha @@ -505,22 +496,22 @@ - GC_ID:1 - charophyte/embryophyte group - ncbi_taxonomy - Charophyta/Embryophyta group - Streptophytina + GC_ID:1 + charophyte/embryophyte group + ncbi_taxonomy + Charophyta/Embryophyta group + Streptophytina - charophyte/embryophyte group + charophyte/embryophyte group - Charophyta/Embryophyta group + Charophyta/Embryophyta group @@ -531,9 +522,9 @@ - GC_ID:1 - ncbi_taxonomy - Xenacoelomorpha + GC_ID:1 + ncbi_taxonomy + Xenacoelomorpha @@ -542,15 +533,15 @@ - GC_ID:1 - ncbi_taxonomy - biota - cellular organisms + GC_ID:1 + ncbi_taxonomy + biota + cellular organisms - biota + biota @@ -561,24 +552,24 @@ - GC_ID:1 - PMID:22839753 - PMID:25450099 - ncbi_taxonomy - Archosauria-Testudines - Testudines + Archosauria group - Archelosauria + GC_ID:1 + PMID:22839753 + PMID:25450099 + ncbi_taxonomy + Archosauria-Testudines + Testudines + Archosauria group + Archelosauria - Archosauria-Testudines + Archosauria-Testudines - Testudines + Archosauria group + Testudines + Archosauria group @@ -589,9 +580,9 @@ - GC_ID:1 - ncbi_taxonomy - Dipnotetrapodomorpha + GC_ID:1 + ncbi_taxonomy + Dipnotetrapodomorpha @@ -601,17 +592,17 @@ - GC_ID:1 - PMID:11743200 - PMID:11791233 - ncbi_taxonomy - Boreotheria - Boreoeutheria + GC_ID:1 + PMID:11743200 + PMID:11791233 + ncbi_taxonomy + Boreotheria + Boreoeutheria - Boreotheria + Boreotheria @@ -622,9 +613,9 @@ - GC_ID:1 - ncbi_taxonomy - Acrogymnospermae + GC_ID:1 + ncbi_taxonomy + Acrogymnospermae @@ -634,10 +625,10 @@ - GC_ID:1 - PMID:25249442 - ncbi_taxonomy - Mesangiospermae + GC_ID:1 + PMID:25249442 + ncbi_taxonomy + Mesangiospermae @@ -647,10 +638,10 @@ - GC_ID:1 - PMID:26350789 - ncbi_taxonomy - Petrosaviidae + GC_ID:1 + PMID:26350789 + ncbi_taxonomy + Petrosaviidae @@ -660,9 +651,9 @@ - GC_ID:1 - ncbi_taxonomy - Pinales + GC_ID:1 + ncbi_taxonomy + Pinales @@ -672,9 +663,9 @@ - GC_ID:1 - ncbi_taxonomy - Acoelomorpha + GC_ID:1 + ncbi_taxonomy + Acoelomorpha @@ -684,15 +675,15 @@ - GC_ID:1 - true yeasts - ncbi_taxonomy - Saccharomycotina + GC_ID:1 + true yeasts + ncbi_taxonomy + Saccharomycotina - true yeasts + true yeasts @@ -703,15 +694,15 @@ - GC_ID:1 - ncbi_taxonomy - Archiascomycota - Schizosaccharomycetes + GC_ID:1 + ncbi_taxonomy + Archiascomycota + Schizosaccharomycetes - Archiascomycota + Archiascomycota @@ -722,9 +713,9 @@ - GC_ID:1 - ncbi_taxonomy - Osteoglossocephalai + GC_ID:1 + ncbi_taxonomy + Osteoglossocephalai @@ -734,9 +725,9 @@ - GC_ID:1 - ncbi_taxonomy - Euteleosteomorpha + GC_ID:1 + ncbi_taxonomy + Euteleosteomorpha @@ -746,9 +737,9 @@ - GC_ID:1 - ncbi_taxonomy - Percomorphaceae + GC_ID:1 + ncbi_taxonomy + Percomorphaceae @@ -758,22 +749,22 @@ - GC_ID:1 - ncbi_taxonomy - Carangimorpha - Carangimorphariae - Carangaria + GC_ID:1 + ncbi_taxonomy + Carangimorpha + Carangimorphariae + Carangaria - Carangimorpha + Carangimorpha - Carangimorphariae + Carangimorphariae @@ -784,9 +775,9 @@ - GC_ID:1 - ncbi_taxonomy - Xenoturbellidae + GC_ID:1 + ncbi_taxonomy + Xenoturbellidae @@ -796,22 +787,22 @@ - GC_ID:1 - ncbi_taxonomy - Galloanseri - ducks, geese, chickens, fowl, quail, currasows and allies - Galloanserae + GC_ID:1 + ncbi_taxonomy + Galloanseri + ducks, geese, chickens, fowl, quail, currasows and allies + Galloanserae - Galloanseri + Galloanseri - ducks, geese, chickens, fowl, quail, currasows and allies + ducks, geese, chickens, fowl, quail, currasows and allies @@ -822,23 +813,23 @@ - NCBITaxon:29008 - GC_ID:1 - ncbi_taxonomy - Eisenia fetida andrei - Eiseniella andrei - Eisenia andrei + NCBITaxon:29008 + GC_ID:1 + ncbi_taxonomy + Eisenia fetida andrei + Eiseniella andrei + Eisenia andrei - Eisenia fetida andrei + Eisenia fetida andrei - Eiseniella andrei + Eiseniella andrei @@ -849,9 +840,9 @@ - GC_ID:1 - ncbi_taxonomy - Actinopteri + GC_ID:1 + ncbi_taxonomy + Actinopteri @@ -860,9 +851,9 @@ - GC_ID:1 - ncbi_taxonomy - Clupeocephala + GC_ID:1 + ncbi_taxonomy + Clupeocephala @@ -872,15 +863,15 @@ - GC_ID:1 - ncbi_taxonomy - Otophysa - Otophysi + GC_ID:1 + ncbi_taxonomy + Otophysa + Otophysi - Otophysa + Otophysa @@ -891,15 +882,15 @@ - GC_ID:1 - ncbi_taxonomy - Cypriniphysi - Cypriniphysae + GC_ID:1 + ncbi_taxonomy + Cypriniphysi + Cypriniphysae - Cypriniphysi + Cypriniphysi @@ -910,22 +901,22 @@ - GC_ID:1 - ncbi_taxonomy - Ostarioclupeomorpha - Otocephala - Otomorpha + GC_ID:1 + ncbi_taxonomy + Ostarioclupeomorpha + Otocephala + Otomorpha - Ostarioclupeomorpha + Ostarioclupeomorpha - Otocephala + Otocephala @@ -936,22 +927,22 @@ - GC_ID:1 - mice and others - ncbi_taxonomy - Sciurognathi - Myomorpha + GC_ID:1 + mice and others + ncbi_taxonomy + Sciurognathi + Myomorpha - mice and others + mice and others - Sciurognathi + Sciurognathi @@ -962,9 +953,9 @@ - GC_ID:1 - ncbi_taxonomy - Enchytraeida + GC_ID:1 + ncbi_taxonomy + Enchytraeida @@ -974,11 +965,11 @@ - GC_ID:1 - PMID:10874751 - PMID:11557979 - ncbi_taxonomy - Pancrustacea + GC_ID:1 + PMID:10874751 + PMID:11557979 + ncbi_taxonomy + Pancrustacea @@ -988,18 +979,18 @@ - GC_ID:1 - PMID:11557979 - PMID:9727836 - mandibulates - ncbi_taxonomy - Mandibulata + GC_ID:1 + PMID:11557979 + PMID:9727836 + mandibulates + ncbi_taxonomy + Mandibulata - mandibulates - + mandibulates + @@ -1009,15 +1000,15 @@ - GC_ID:1 - ncbi_taxonomy - Homo/Pan/Gorilla group - Homininae + GC_ID:1 + ncbi_taxonomy + Homo/Pan/Gorilla group + Homininae - Homo/Pan/Gorilla group + Homo/Pan/Gorilla group @@ -1028,9 +1019,9 @@ - GC_ID:1 - ncbi_taxonomy - Multicrustacea + GC_ID:1 + ncbi_taxonomy + Multicrustacea @@ -1040,9 +1031,9 @@ - GC_ID:1 - ncbi_taxonomy - Hirudinida + GC_ID:1 + ncbi_taxonomy + Hirudinida @@ -1052,9 +1043,9 @@ - GC_ID:1 - ncbi_taxonomy - Rhabditina + GC_ID:1 + ncbi_taxonomy + Rhabditina @@ -1064,9 +1055,9 @@ - GC_ID:1 - ncbi_taxonomy - Rhabditomorpha + GC_ID:1 + ncbi_taxonomy + Rhabditomorpha @@ -1076,9 +1067,9 @@ - GC_ID:1 - ncbi_taxonomy - Discoba + GC_ID:1 + ncbi_taxonomy + Discoba @@ -1088,9 +1079,9 @@ - GC_ID:1 - ncbi_taxonomy - Ochrophyta + GC_ID:1 + ncbi_taxonomy + Ochrophyta @@ -1100,9 +1091,9 @@ - GC_ID:1 - ncbi_taxonomy - Spiralia + GC_ID:1 + ncbi_taxonomy + Spiralia @@ -1112,15 +1103,15 @@ - GC_ID:1 - ncbi_taxonomy - SAR supergroup - Sar + GC_ID:1 + ncbi_taxonomy + SAR supergroup + Sar - SAR supergroup + SAR supergroup @@ -1131,9 +1122,9 @@ - GC_ID:1 - ncbi_taxonomy - Danionidae + GC_ID:1 + ncbi_taxonomy + Danionidae @@ -1143,9 +1134,9 @@ - GC_ID:1 - ncbi_taxonomy - Danioninae + GC_ID:1 + ncbi_taxonomy + Danioninae @@ -1155,59 +1146,59 @@ - GC_ID:1 - PMID:23020233 - PMID:30257078 - eucaryotes - eukaryotes - ncbi_taxonomy - Eucarya - Eucaryotae - Eukarya - Eukaryotae - eukaryotes - Eukaryota + GC_ID:1 + PMID:23020233 + PMID:30257078 + eucaryotes + eukaryotes + ncbi_taxonomy + Eucarya + Eucaryotae + Eukarya + Eukaryotae + eukaryotes + Eukaryota - eucaryotes + eucaryotes - eukaryotes - + eukaryotes + - Eucarya + Eucarya - Eucaryotae + Eucaryotae - Eukarya + Eukarya - Eukaryotae + Eukaryotae - eukaryotes + eukaryotes @@ -1218,9 +1209,9 @@ - GC_ID:1 - ncbi_taxonomy - Bovinae + GC_ID:1 + ncbi_taxonomy + Bovinae @@ -1230,9 +1221,9 @@ - GC_ID:1 - ncbi_taxonomy - Crassiclitellata + GC_ID:1 + ncbi_taxonomy + Crassiclitellata @@ -1242,10 +1233,10 @@ - GC_ID:1 - PMID:19761858 - ncbi_taxonomy - Conifers I + GC_ID:1 + PMID:19761858 + ncbi_taxonomy + Conifers I @@ -1255,50 +1246,50 @@ - GC_ID:1 - brown algae - ncbi_taxonomy - Chromophycota - Fucophyceae - Phaeophyta - algae - brown algae - Phaeophyceae + GC_ID:1 + brown algae + ncbi_taxonomy + Chromophycota + Fucophyceae + Phaeophyta + algae + brown algae + Phaeophyceae - brown algae + brown algae - Chromophycota + Chromophycota - Fucophyceae + Fucophyceae - Phaeophyta + Phaeophyta - algae + algae - brown algae + brown algae @@ -1309,9 +1300,9 @@ - GC_ID:1 - ncbi_taxonomy - Oryzomys + GC_ID:1 + ncbi_taxonomy + Oryzomys @@ -1321,9 +1312,9 @@ - GC_ID:1 - ncbi_taxonomy - Cancroidea + GC_ID:1 + ncbi_taxonomy + Cancroidea @@ -1333,60 +1324,41 @@ - GC_ID:1 - Ranoidea - ncbi_taxonomy - Ranoidea Rafinesque, 1814 - Ranoidea <superfamily> + GC_ID:1 + Ranoidea + ncbi_taxonomy + Ranoidea Rafinesque, 1814 + Ranoidea <superfamily> - Ranoidea + Ranoidea - Ranoidea Rafinesque, 1814 + Ranoidea Rafinesque, 1814 - - - - - - GC_ID:1 - Anthophila - ncbi_taxonomy - Anthophila <bees> - - - - - Anthophila - - - - - - GC_ID:1 - ncbi_taxonomy - Cyprinoidea - Cyprinoidei + GC_ID:1 + ncbi_taxonomy + Cyprinoidea + Cyprinoidei - Cyprinoidea + Cyprinoidea @@ -1397,16 +1369,16 @@ - NCBITaxon:30946 - GC_ID:1 - ncbi_taxonomy - Soleoidei - Pleuronectoidei + NCBITaxon:30946 + GC_ID:1 + ncbi_taxonomy + Soleoidei + Pleuronectoidei - Soleoidei + Soleoidei @@ -1417,12 +1389,12 @@ - GC_ID:1 - PMID:11214318 - PMID:11214319 - PMID:12878460 - ncbi_taxonomy - Laurasiatheria + GC_ID:1 + PMID:11214318 + PMID:11214319 + PMID:12878460 + ncbi_taxonomy + Laurasiatheria @@ -1432,13 +1404,13 @@ - GC_ID:1 - PMID:11214319 - PMID:12082125 - PMID:12878460 - PMID:15522813 - ncbi_taxonomy - Euarchontoglires + GC_ID:1 + PMID:11214319 + PMID:12082125 + PMID:12878460 + PMID:15522813 + ncbi_taxonomy + Euarchontoglires @@ -1448,18 +1420,18 @@ - GC_ID:1 - PMID:11214319 - PMID:12082125 - PMID:15522813 - Rodents and rabbits - ncbi_taxonomy - Glires + GC_ID:1 + PMID:11214319 + PMID:12082125 + PMID:15522813 + Rodents and rabbits + ncbi_taxonomy + Glires - Rodents and rabbits + Rodents and rabbits @@ -1470,15 +1442,15 @@ - GC_ID:1 - ncbi_taxonomy - Anthropoidea - Simiiformes + GC_ID:1 + ncbi_taxonomy + Anthropoidea + Simiiformes - Anthropoidea + Anthropoidea @@ -1489,9 +1461,9 @@ - GC_ID:1 - ncbi_taxonomy - Cercopithecoidea + GC_ID:1 + ncbi_taxonomy + Cercopithecoidea @@ -1501,22 +1473,22 @@ - GC_ID:1 - ape - apes - ncbi_taxonomy - Hominoidea + GC_ID:1 + ape + apes + ncbi_taxonomy + Hominoidea - ape - + ape + - apes + apes @@ -1527,36 +1499,36 @@ - GC_ID:1 - higher plants - land plants - plants - ncbi_taxonomy - land plants - Embryophyta + GC_ID:1 + higher plants + land plants + plants + ncbi_taxonomy + land plants + Embryophyta - higher plants - + higher plants + - land plants - + land plants + - plants - + plants + - land plants + land plants @@ -1567,37 +1539,44 @@ - NCBITaxon:3194 - GC_ID:1 - mosses - ncbi_taxonomy - Musci - bryophytes - mosses - Bryophyta + NCBITaxon:3194 + GC_ID:1 + mosses + ncbi_taxonomy + Bryopsida + Musci + bryophytes + mosses + Bryophyta - mosses + mosses - Musci + Bryopsida + + + + + + Musci - bryophytes + bryophytes - mosses + mosses @@ -1608,15 +1587,15 @@ - GC_ID:1 - teleost fishes - ncbi_taxonomy - Teleostei + GC_ID:1 + teleost fishes + ncbi_taxonomy + Teleostei - teleost fishes + teleost fishes @@ -1627,9 +1606,9 @@ - GC_ID:1 - ncbi_taxonomy - Ostariophysi + GC_ID:1 + ncbi_taxonomy + Ostariophysi @@ -1639,15 +1618,15 @@ - GC_ID:1 - tetrapods - ncbi_taxonomy - Tetrapoda + GC_ID:1 + tetrapods + ncbi_taxonomy + Tetrapoda - tetrapods + tetrapods @@ -1658,15 +1637,15 @@ - GC_ID:1 - amniotes - ncbi_taxonomy - Amniota + GC_ID:1 + amniotes + ncbi_taxonomy + Amniota - amniotes + amniotes @@ -1677,15 +1656,15 @@ - GC_ID:1 - Theria - ncbi_taxonomy - Theria <mammals> + GC_ID:1 + Theria + ncbi_taxonomy + Theria <mammals> - Theria + Theria @@ -1696,22 +1675,22 @@ - GC_ID:1 - diapsids - ncbi_taxonomy - Diapsida - Sauria + GC_ID:1 + diapsids + ncbi_taxonomy + Diapsida + Sauria - diapsids + diapsids - Diapsida + Diapsida @@ -1722,52 +1701,52 @@ - GC_ID:1 - PMID:16248873 - PMID:30257078 - Chlorophyta/Embryophyta group - chlorophyte/embryophyte group - green plants - ncbi_taxonomy - Chlorobionta - Chloroplastida - green plants - Viridiplantae + GC_ID:1 + PMID:16248873 + PMID:30257078 + Chlorophyta/Embryophyta group + chlorophyte/embryophyte group + green plants + ncbi_taxonomy + Chlorobionta + Chloroplastida + green plants + Viridiplantae - Chlorophyta/Embryophyta group + Chlorophyta/Embryophyta group - chlorophyte/embryophyte group + chlorophyte/embryophyte group - green plants - + green plants + - Chlorobionta + Chlorobionta - Chloroplastida + Chloroplastida - green plants + green plants @@ -1778,16 +1757,16 @@ - NCBITaxon:1445965 - GC_ID:1 - ncbi_taxonomy - Coniferales - Pinidae + NCBITaxon:1445965 + GC_ID:1 + ncbi_taxonomy + Coniferales + Pinidae - Coniferales + Coniferales @@ -1798,22 +1777,22 @@ - GC_ID:1 - ncbi_taxonomy - Fungi/Metazoa group - opisthokonts - Opisthokonta + GC_ID:1 + ncbi_taxonomy + Fungi/Metazoa group + opisthokonts + Opisthokonta - Fungi/Metazoa group + Fungi/Metazoa group - opisthokonts + opisthokonts @@ -1824,16 +1803,16 @@ - GC_ID:1 - pine family - ncbi_taxonomy - Pinaceae + GC_ID:1 + pine family + ncbi_taxonomy + Pinaceae - pine family - + pine family + @@ -1843,36 +1822,36 @@ - GC_ID:1 - metazoans - multicellular animals - ncbi_taxonomy - Animalia - animals - Metazoa + GC_ID:1 + metazoans + multicellular animals + ncbi_taxonomy + Animalia + animals + Metazoa - metazoans + metazoans - multicellular animals - + multicellular animals + - Animalia + Animalia - animals + animals @@ -1883,9 +1862,9 @@ - GC_ID:1 - ncbi_taxonomy - Bilateria + GC_ID:1 + ncbi_taxonomy + Bilateria @@ -1895,9 +1874,9 @@ - GC_ID:1 - ncbi_taxonomy - Protostomia + GC_ID:1 + ncbi_taxonomy + Protostomia @@ -1907,9 +1886,9 @@ - GC_ID:1 - ncbi_taxonomy - Neoptera + GC_ID:1 + ncbi_taxonomy + Neoptera @@ -1919,15 +1898,15 @@ - GC_ID:1 - ncbi_taxonomy - Holometabola - Endopterygota + GC_ID:1 + ncbi_taxonomy + Holometabola + Endopterygota - Holometabola + Holometabola @@ -1938,16 +1917,16 @@ - GC_ID:1 - deuterostomes - ncbi_taxonomy - Deuterostomia + GC_ID:1 + deuterostomes + ncbi_taxonomy + Deuterostomia - deuterostomes - + deuterostomes + @@ -1957,22 +1936,22 @@ - GC_ID:1 - carnivores - ncbi_taxonomy - carnivores - Carnivora + GC_ID:1 + carnivores + ncbi_taxonomy + carnivores + Carnivora - carnivores + carnivores - carnivores + carnivores @@ -1983,15 +1962,15 @@ - GC_ID:1 - alveolates - ncbi_taxonomy - Alveolata + GC_ID:1 + alveolates + ncbi_taxonomy + Alveolata - alveolates + alveolates @@ -2002,36 +1981,36 @@ - GC_ID:1 - heterokonts - ncbi_taxonomy - Chromophyta - Heterokonta - Straminipila - Stramenopiles + GC_ID:1 + heterokonts + ncbi_taxonomy + Chromophyta + Heterokonta + Straminipila + Stramenopiles - heterokonts + heterokonts - Chromophyta + Chromophyta - Heterokonta + Heterokonta - Straminipila + Straminipila @@ -2042,15 +2021,15 @@ - GC_ID:1 - ncbi_taxonomy - Euglenozoans - Euglenozoa + GC_ID:1 + ncbi_taxonomy + Euglenozoans + Euglenozoa - Euglenozoans + Euglenozoans @@ -2061,10 +2040,10 @@ - GC_ID:1 - PMID:15371245 - ncbi_taxonomy - Cricetidae + GC_ID:1 + PMID:15371245 + ncbi_taxonomy + Cricetidae @@ -2074,11 +2053,11 @@ - GC_ID:1 - PMID:15019624 - PMID:15371245 - ncbi_taxonomy - Muroidea + GC_ID:1 + PMID:15019624 + PMID:15371245 + ncbi_taxonomy + Muroidea @@ -2088,9 +2067,9 @@ - GC_ID:1 - ncbi_taxonomy - Felinae + GC_ID:1 + ncbi_taxonomy + Felinae @@ -2100,44 +2079,44 @@ - GC_ID:1 - PMID:25249442 - angiosperms - flowering plants - ncbi_taxonomy - Angiospermae - Magnoliophyta - flowering plants - Magnoliopsida + GC_ID:1 + PMID:25249442 + angiosperms + flowering plants + ncbi_taxonomy + Angiospermae + Magnoliophyta + flowering plants + Magnoliopsida - angiosperms - + angiosperms + - flowering plants + flowering plants - Angiospermae + Angiospermae - Magnoliophyta + Magnoliophyta - flowering plants + flowering plants @@ -2148,9 +2127,9 @@ - GC_ID:1 - ncbi_taxonomy - Schizosaccharomycetales + GC_ID:1 + ncbi_taxonomy + Schizosaccharomycetales @@ -2160,29 +2139,29 @@ - GC_ID:1 - bee - bees - ncbi_taxonomy - bees - Apoidea + GC_ID:1 + bee + bees + ncbi_taxonomy + bees + Apoidea - bee - + bee + - bees + bees - bees + bees @@ -2193,9 +2172,9 @@ - GC_ID:1 - ncbi_taxonomy - Streptophyta + GC_ID:1 + ncbi_taxonomy + Streptophyta @@ -2205,15 +2184,15 @@ - GC_ID:1 - ncbi_taxonomy - Suiformes - Suina + GC_ID:1 + ncbi_taxonomy + Suiformes + Suina - Suiformes + Suiformes @@ -2224,9 +2203,9 @@ - GC_ID:1 - ncbi_taxonomy - Pecora + GC_ID:1 + ncbi_taxonomy + Pecora @@ -2236,9 +2215,9 @@ - GC_ID:1 - ncbi_taxonomy - Ditrysia + GC_ID:1 + ncbi_taxonomy + Ditrysia @@ -2248,22 +2227,22 @@ - GC_ID:1 - butterflies - ncbi_taxonomy - butterflies - Papilionoidea + GC_ID:1 + butterflies + ncbi_taxonomy + butterflies + Papilionoidea - butterflies + butterflies - butterflies + butterflies @@ -2274,9 +2253,9 @@ - GC_ID:1 - ncbi_taxonomy - Haplorrhini + GC_ID:1 + ncbi_taxonomy + Haplorrhini @@ -2286,9 +2265,9 @@ - GC_ID:1 - ncbi_taxonomy - Feliformia + GC_ID:1 + ncbi_taxonomy + Feliformia @@ -2298,9 +2277,9 @@ - GC_ID:1 - ncbi_taxonomy - Caniformia + GC_ID:1 + ncbi_taxonomy + Caniformia @@ -2310,9 +2289,9 @@ - GC_ID:1 - ncbi_taxonomy - Artemiidae + GC_ID:1 + ncbi_taxonomy + Artemiidae @@ -2322,36 +2301,36 @@ - GC_ID:1 - glaucocystophytes - ncbi_taxonomy - Glaucophyceae - Glaucophyta - algae - Glaucocystophyceae + GC_ID:1 + glaucocystophytes + ncbi_taxonomy + Glaucophyceae + Glaucophyta + algae + Glaucocystophyceae - glaucocystophytes - + glaucocystophytes + - Glaucophyceae + Glaucophyceae - Glaucophyta + Glaucophyta - algae + algae @@ -2362,12 +2341,12 @@ - NCBITaxon:4478 - NCBITaxon:4727 - GC_ID:1 - PMID:26350789 - ncbi_taxonomy - Poales + NCBITaxon:4478 + NCBITaxon:4727 + GC_ID:1 + PMID:26350789 + ncbi_taxonomy + Poales @@ -2377,10 +2356,10 @@ - NCBITaxon:109679 - GC_ID:1 - ncbi_taxonomy - Murinae + NCBITaxon:109679 + GC_ID:1 + ncbi_taxonomy + Murinae @@ -2390,11 +2369,11 @@ - GC_ID:1 - PMID:15019624 - PMID:15371245 - ncbi_taxonomy - Sigmodontinae + GC_ID:1 + PMID:15019624 + PMID:15371245 + ncbi_taxonomy + Sigmodontinae @@ -2404,22 +2383,22 @@ - GC_ID:1 - mammals - ncbi_taxonomy - mammals - Mammalia + GC_ID:1 + mammals + ncbi_taxonomy + mammals + Mammalia - mammals + mammals - mammals + mammals @@ -2430,9 +2409,9 @@ - GC_ID:1 - ncbi_taxonomy - Glossata + GC_ID:1 + ncbi_taxonomy + Glossata @@ -2442,9 +2421,9 @@ - GC_ID:1 - ncbi_taxonomy - Neolepidoptera + GC_ID:1 + ncbi_taxonomy + Neolepidoptera @@ -2454,10 +2433,10 @@ - NCBITaxon:37583 - GC_ID:1 - ncbi_taxonomy - Heteroneura + NCBITaxon:37583 + GC_ID:1 + ncbi_taxonomy + Heteroneura @@ -2467,15 +2446,15 @@ - GC_ID:1 - ncbi_taxonomy - Neopterygi - Neopterygii + GC_ID:1 + ncbi_taxonomy + Neopterygi + Neopterygii - Neopterygi + Neopterygi @@ -2486,9 +2465,9 @@ - GC_ID:1 - ncbi_taxonomy - Batrachia + GC_ID:1 + ncbi_taxonomy + Batrachia @@ -2498,9 +2477,9 @@ - GC_ID:1 - ncbi_taxonomy - Protacanthopterygii + GC_ID:1 + ncbi_taxonomy + Protacanthopterygii @@ -2510,9 +2489,9 @@ - GC_ID:1 - ncbi_taxonomy - Clitellata + GC_ID:1 + ncbi_taxonomy + Clitellata @@ -2522,23 +2501,23 @@ - GC_ID:1 - dinosaur - dinosaurs - ncbi_taxonomy - Dinosauria + GC_ID:1 + dinosaur + dinosaurs + ncbi_taxonomy + Dinosauria - dinosaur - + dinosaur + - dinosaurs - + dinosaurs + @@ -2548,9 +2527,9 @@ - GC_ID:1 - ncbi_taxonomy - Saurischia + GC_ID:1 + ncbi_taxonomy + Saurischia @@ -2560,9 +2539,9 @@ - GC_ID:1 - ncbi_taxonomy - Theropoda + GC_ID:1 + ncbi_taxonomy + Theropoda @@ -2572,9 +2551,9 @@ - GC_ID:1 - ncbi_taxonomy - Coelurosauria + GC_ID:1 + ncbi_taxonomy + Coelurosauria @@ -2584,16 +2563,16 @@ - NCBITaxon:43732 - GC_ID:1 - ncbi_taxonomy - Asilomorpha - Muscomorpha + NCBITaxon:43732 + GC_ID:1 + ncbi_taxonomy + Asilomorpha + Muscomorpha - Asilomorpha + Asilomorpha @@ -2603,9 +2582,9 @@ - GC_ID:1 - ncbi_taxonomy - Schizophora + GC_ID:1 + ncbi_taxonomy + Schizophora @@ -2614,9 +2593,9 @@ - GC_ID:1 - ncbi_taxonomy - Acalyptratae + GC_ID:1 + ncbi_taxonomy + Acalyptratae @@ -2626,9 +2605,9 @@ - GC_ID:1 - ncbi_taxonomy - Ephydroidea + GC_ID:1 + ncbi_taxonomy + Ephydroidea @@ -2638,9 +2617,9 @@ - GC_ID:1 - ncbi_taxonomy - Drosophilinae + GC_ID:1 + ncbi_taxonomy + Drosophilinae @@ -2650,37 +2629,37 @@ - GC_ID:1 - PMID:25249442 - monocots - monocotyledons - ncbi_taxonomy - Monocotyledoneae - monocots - Liliopsida + GC_ID:1 + PMID:25249442 + monocots + monocotyledons + ncbi_taxonomy + Monocotyledoneae + monocots + Liliopsida - monocots - + monocots + - monocotyledons + monocotyledons - Monocotyledoneae + Monocotyledoneae - monocots + monocots @@ -2691,30 +2670,30 @@ - NCBITaxon:1661618 - GC_ID:1 - grass family - ncbi_taxonomy - Bambusaceae - Gramineae - Poaceae + NCBITaxon:1661618 + GC_ID:1 + grass family + ncbi_taxonomy + Bambusaceae + Gramineae + Poaceae - grass family - + grass family + - Bambusaceae + Bambusaceae - Gramineae + Gramineae @@ -2725,14 +2704,14 @@ - GC_ID:1 - PMID:15689432 - PMID:16151185 - PMID:17010206 - PMID:17051209 - PMID:17572334 - ncbi_taxonomy - Dikarya + GC_ID:1 + PMID:15689432 + PMID:16151185 + PMID:17010206 + PMID:17051209 + PMID:17572334 + ncbi_taxonomy + Dikarya @@ -2742,9 +2721,9 @@ - GC_ID:1 - ncbi_taxonomy - Taphrinomycotina + GC_ID:1 + ncbi_taxonomy + Taphrinomycotina @@ -2754,9 +2733,9 @@ - GC_ID:1 - ncbi_taxonomy - Drosophilini + GC_ID:1 + ncbi_taxonomy + Drosophilini @@ -2766,23 +2745,23 @@ - GC_ID:1 - PMID:26350789 - ncbi_taxonomy - Commelinidae - Commeliniflorae - commelinids + GC_ID:1 + PMID:26350789 + ncbi_taxonomy + Commelinidae + Commeliniflorae + commelinids - Commelinidae + Commelinidae - Commeliniflorae + Commeliniflorae @@ -2793,24 +2772,24 @@ - GC_ID:1 - PMID:11062127 - PMID:12684019 - ncbi_taxonomy - Mycota - fungi - Fungi + GC_ID:1 + PMID:11062127 + PMID:12684019 + ncbi_taxonomy + Mycota + fungi + Fungi - Mycota + Mycota - fungi + fungi @@ -2821,9 +2800,9 @@ - GC_ID:1 - ncbi_taxonomy - Cyclorrhapha + GC_ID:1 + ncbi_taxonomy + Cyclorrhapha @@ -2833,9 +2812,9 @@ - GC_ID:1 - ncbi_taxonomy - Eremoneura + GC_ID:1 + ncbi_taxonomy + Eremoneura @@ -2845,30 +2824,30 @@ - GC_ID:1 - PMID:17572334 - ascomycetes - sac fungi - ncbi_taxonomy - ascomycete fungi - Ascomycota + GC_ID:1 + PMID:17572334 + ascomycetes + sac fungi + ncbi_taxonomy + ascomycete fungi + Ascomycota - ascomycetes + ascomycetes - sac fungi - + sac fungi + - ascomycete fungi + ascomycete fungi @@ -2879,15 +2858,15 @@ - GC_ID:1 - ncbi_taxonomy - Hemiascomycetes - Saccharomycetes + GC_ID:1 + ncbi_taxonomy + Hemiascomycetes + Saccharomycetes - Hemiascomycetes + Hemiascomycetes @@ -2898,22 +2877,22 @@ - GC_ID:1 - ncbi_taxonomy - Endomycetales - budding yeasts - Saccharomycetales + GC_ID:1 + ncbi_taxonomy + Endomycetales + budding yeasts + Saccharomycetales - Endomycetales + Endomycetales - budding yeasts + budding yeasts @@ -2924,11 +2903,11 @@ - NCBITaxon:221665 - NCBITaxon:44280 - GC_ID:1 - ncbi_taxonomy - Saccharomycetaceae + NCBITaxon:221665 + NCBITaxon:44280 + GC_ID:1 + ncbi_taxonomy + Saccharomycetaceae @@ -2938,22 +2917,22 @@ - GC_ID:1 - fission yeasts - ncbi_taxonomy - Schizosaccharomycetoideae - Schizosaccharomycetaceae + GC_ID:1 + fission yeasts + ncbi_taxonomy + Schizosaccharomycetoideae + Schizosaccharomycetaceae - fission yeasts + fission yeasts - Schizosaccharomycetoideae + Schizosaccharomycetoideae @@ -2964,9 +2943,9 @@ - GC_ID:1 - ncbi_taxonomy - Schizosaccharomyces + GC_ID:1 + ncbi_taxonomy + Schizosaccharomyces @@ -2976,23 +2955,23 @@ - NCBITaxon:45042 - GC_ID:1 - fission yeast - ncbi_taxonomy - Schizosaccharomyces malidevorans - Schizosaccharomyces pombe + NCBITaxon:45042 + GC_ID:1 + fission yeast + ncbi_taxonomy + Schizosaccharomyces malidevorans + Schizosaccharomyces pombe - fission yeast + fission yeast - Schizosaccharomyces malidevorans + Schizosaccharomyces malidevorans @@ -3003,16 +2982,16 @@ - NCBITaxon:36915 - GC_ID:1 - ncbi_taxonomy - Pachytichospora - Saccharomyces + NCBITaxon:36915 + GC_ID:1 + ncbi_taxonomy + Pachytichospora + Saccharomyces - Pachytichospora + Pachytichospora @@ -3023,79 +3002,71 @@ - NCBITaxon:41870 - GC_ID:1 - Saccharomyces cerevisiae 'var. diastaticus' - baker's yeast - brewer's yeast - ncbi_taxonomy - Candida robusta - Mycoderma cerevisiae - Saccharomyces capensis - Saccharomyces diastaticus - Saccharomyces italicus - Saccharomyces oviformis - Saccharomyces uvarum var. melibiosus - Saccharomyces cerevisiae + GC_ID:1 + S. cerevisiae + baker's yeast + brewer's yeast + ncbi_taxonomy + Candida robusta + Mycoderma cerevisiae + Saccharomyces capensis + Saccharomyces italicus + Saccharomyces oviformis + Saccharomyces uvarum var. melibiosus + Saccharomyces cerevisiae - Saccharomyces cerevisiae 'var. diastaticus' - - - - - - baker's yeast - + S. cerevisiae + - brewer's yeast + baker's yeast - - Candida robusta - + + brewer's yeast + - Mycoderma cerevisiae + Candida robusta - Saccharomyces capensis + Mycoderma cerevisiae - Saccharomyces diastaticus + Saccharomyces capensis - Saccharomyces italicus + Saccharomyces italicus - Saccharomyces oviformis + Saccharomyces oviformis - Saccharomyces uvarum var. melibiosus + Saccharomyces uvarum var. melibiosus @@ -3106,15 +3077,15 @@ - GC_ID:1 - trouts, salmons & chars - ncbi_taxonomy - Salmoninae + GC_ID:1 + trouts, salmons & chars + ncbi_taxonomy + Salmoninae - trouts, salmons & chars + trouts, salmons & chars @@ -3125,22 +3096,22 @@ - GC_ID:1 - true insects - ncbi_taxonomy - insects - Insecta + GC_ID:1 + true insects + ncbi_taxonomy + insects + Insecta - true insects + true insects - insects + insects @@ -3151,16 +3122,16 @@ - NCBITaxon:6403 - GC_ID:1 - leeches - ncbi_taxonomy - Hirudinea + NCBITaxon:6403 + GC_ID:1 + leeches + ncbi_taxonomy + Hirudinea - leeches + leeches @@ -3171,9 +3142,9 @@ - GC_ID:1 - ncbi_taxonomy - Rhabditoidea + GC_ID:1 + ncbi_taxonomy + Rhabditoidea @@ -3183,9 +3154,9 @@ - GC_ID:1 - ncbi_taxonomy - Peloderinae + GC_ID:1 + ncbi_taxonomy + Peloderinae @@ -3195,15 +3166,15 @@ - GC_ID:1 - ncbi_taxonomy - algae - PX clade + GC_ID:1 + ncbi_taxonomy + algae + PX clade - algae + algae @@ -3214,15 +3185,15 @@ - GC_ID:1 - ncbi_taxonomy - Coniferopsida - Pinopsida + GC_ID:1 + ncbi_taxonomy + Coniferopsida + Pinopsida - Coniferopsida + Coniferopsida @@ -3233,22 +3204,22 @@ - GC_ID:1 - vascular plants - ncbi_taxonomy - vascular plants - Tracheophyta + GC_ID:1 + vascular plants + ncbi_taxonomy + vascular plants + Tracheophyta - vascular plants - + vascular plants + - vascular plants + vascular plants @@ -3259,22 +3230,22 @@ - GC_ID:1 - seed plants - ncbi_taxonomy - seed plants - Spermatophyta + GC_ID:1 + seed plants + ncbi_taxonomy + seed plants + Spermatophyta - seed plants - + seed plants + - seed plants + seed plants @@ -3285,9 +3256,9 @@ - GC_ID:1 - ncbi_taxonomy - Eumetazoa + GC_ID:1 + ncbi_taxonomy + Eumetazoa @@ -3297,29 +3268,29 @@ - GC_ID:1 - flatworm - flatworms - ncbi_taxonomy - flatworms - Platyhelminthes + GC_ID:1 + flatworm + flatworms + ncbi_taxonomy + flatworms + Platyhelminthes - flatworm - + flatworm + - flatworms + flatworms - flatworms + flatworms @@ -3330,50 +3301,50 @@ - GC_ID:1 - nematode - nematodes - roundworm - roundworms - ncbi_taxonomy - Nemata - nematodes - Nematoda + GC_ID:1 + nematode + nematodes + roundworm + roundworms + ncbi_taxonomy + Nemata + nematodes + Nematoda - nematode - + nematode + - nematodes - + nematodes + - roundworm - + roundworm + - roundworms + roundworms - Nemata + Nemata - nematodes + nematodes @@ -3384,19 +3355,11 @@ - NCBITaxon:33251 - NCBITaxon:6308 - GC_ID:1 - ncbi_taxonomy - Strongylida - Rhabditida + NCBITaxon:33251 + GC_ID:1 + ncbi_taxonomy + Rhabditida - - - - Strongylida - - @@ -3405,9 +3368,9 @@ - GC_ID:1 - ncbi_taxonomy - Caenorhabditis + GC_ID:1 + ncbi_taxonomy + Caenorhabditis @@ -3417,15 +3380,15 @@ - GC_ID:1 - ncbi_taxonomy - Rhabditis elegans - Caenorhabditis elegans + GC_ID:1 + ncbi_taxonomy + Rhabditis elegans + Caenorhabditis elegans - Rhabditis elegans + Rhabditis elegans @@ -3436,10 +3399,10 @@ - NCBITaxon:54603 - GC_ID:1 - ncbi_taxonomy - Rhabditidae + NCBITaxon:54603 + GC_ID:1 + ncbi_taxonomy + Rhabditidae @@ -3449,22 +3412,22 @@ - GC_ID:1 - annelid worms - ncbi_taxonomy - segmented worms - Annelida + GC_ID:1 + annelid worms + ncbi_taxonomy + segmented worms + Annelida - annelid worms + annelid worms - segmented worms + segmented worms @@ -3475,16 +3438,16 @@ - GC_ID:1 - PMID:34811021 - Oligochaeta - ncbi_taxonomy - Oligochaeta <segmented worms> + GC_ID:1 + PMID:34811021 + Oligochaeta + ncbi_taxonomy + Oligochaeta <segmented worms> - Oligochaeta + Oligochaeta @@ -3495,9 +3458,9 @@ - GC_ID:1 - ncbi_taxonomy - Enchytraeidae + GC_ID:1 + ncbi_taxonomy + Enchytraeidae @@ -3507,9 +3470,9 @@ - GC_ID:1 - ncbi_taxonomy - Enchytraeus + GC_ID:1 + ncbi_taxonomy + Enchytraeus @@ -3519,15 +3482,15 @@ - GC_ID:1 - earthworms - ncbi_taxonomy - Lumbricina + GC_ID:1 + earthworms + ncbi_taxonomy + Lumbricina - earthworms + earthworms @@ -3538,9 +3501,9 @@ - GC_ID:1 - ncbi_taxonomy - Lumbricidae + GC_ID:1 + ncbi_taxonomy + Lumbricidae @@ -3550,15 +3513,15 @@ - GC_ID:1 - Eisenia - ncbi_taxonomy - Eisenia <segmented worms> + GC_ID:1 + Eisenia + ncbi_taxonomy + Eisenia <segmented worms> - Eisenia + Eisenia @@ -3569,64 +3532,64 @@ - GC_ID:1 - brandling worm - common brandling worm - common dung-worm - red wiggler worm - redworm - tiger worm - ncbi_taxonomy - Eisenia foetida - Eiseniella fetida - Eisenia fetida + GC_ID:1 + brandling worm + common brandling worm + common dung-worm + red wiggler worm + redworm + tiger worm + ncbi_taxonomy + Eisenia foetida + Eiseniella fetida + Eisenia fetida - brandling worm - + brandling worm + - common brandling worm + common brandling worm - common dung-worm - + common dung-worm + - red wiggler worm - + red wiggler worm + - redworm - + redworm + - tiger worm - + tiger worm + - Eisenia foetida + Eisenia foetida - Eiseniella fetida + Eiseniella fetida @@ -3637,9 +3600,9 @@ - GC_ID:1 - ncbi_taxonomy - Lumbricus + GC_ID:1 + ncbi_taxonomy + Lumbricus @@ -3649,16 +3612,16 @@ - NCBITaxon:2175058 - GC_ID:1 - common earthworm - ncbi_taxonomy - Lumbricus terrestris + NCBITaxon:2175058 + GC_ID:1 + common earthworm + ncbi_taxonomy + Lumbricus terrestris - common earthworm + common earthworm @@ -3669,9 +3632,9 @@ - GC_ID:1 - ncbi_taxonomy - Hirudiniformes + GC_ID:1 + ncbi_taxonomy + Hirudiniformes @@ -3681,9 +3644,9 @@ - GC_ID:1 - ncbi_taxonomy - Hirudinidae + GC_ID:1 + ncbi_taxonomy + Hirudinidae @@ -3693,29 +3656,29 @@ - GC_ID:1 - molluscs - mollusks - ncbi_taxonomy - molluscs - Mollusca + GC_ID:1 + molluscs + mollusks + ncbi_taxonomy + molluscs + Mollusca - molluscs - + molluscs + - mollusks + mollusks - molluscs + molluscs @@ -3726,22 +3689,22 @@ - GC_ID:1 - arthropods - ncbi_taxonomy - arthropods - Arthropoda + GC_ID:1 + arthropods + ncbi_taxonomy + arthropods + Arthropoda - arthropods + arthropods - arthropods + arthropods @@ -3752,22 +3715,22 @@ - GC_ID:1 - crustaceans - ncbi_taxonomy - crustaceans - Crustacea + GC_ID:1 + crustaceans + ncbi_taxonomy + crustaceans + Crustacea - crustaceans + crustaceans - crustaceans + crustaceans @@ -3778,9 +3741,9 @@ - GC_ID:1 - ncbi_taxonomy - Branchiopoda + GC_ID:1 + ncbi_taxonomy + Branchiopoda @@ -3790,15 +3753,15 @@ - GC_ID:1 - fairy shrimps - ncbi_taxonomy - Anostraca + GC_ID:1 + fairy shrimps + ncbi_taxonomy + Anostraca - fairy shrimps + fairy shrimps @@ -3809,23 +3772,23 @@ - GC_ID:1 - brine shrimps - sea monkeys - ncbi_taxonomy - Artemia + GC_ID:1 + brine shrimps + sea monkeys + ncbi_taxonomy + Artemia - brine shrimps + brine shrimps - sea monkeys - + sea monkeys + @@ -3835,22 +3798,22 @@ - GC_ID:1 - water flea - water fleas - ncbi_taxonomy - Cladocera + GC_ID:1 + water flea + water fleas + ncbi_taxonomy + Cladocera - water flea - + water flea + - water fleas + water fleas @@ -3861,23 +3824,23 @@ - NCBITaxon:77736 - GC_ID:1 - common water fleas - ncbi_taxonomy - Daphniopsis - Daphnia + NCBITaxon:77736 + GC_ID:1 + common water fleas + ncbi_taxonomy + Daphniopsis + Daphnia - common water fleas + common water fleas - Daphniopsis + Daphniopsis @@ -3888,9 +3851,9 @@ - GC_ID:1 - ncbi_taxonomy - Malacostraca + GC_ID:1 + ncbi_taxonomy + Malacostraca @@ -3900,9 +3863,9 @@ - GC_ID:1 - ncbi_taxonomy - Eucarida + GC_ID:1 + ncbi_taxonomy + Eucarida @@ -3912,9 +3875,9 @@ - GC_ID:1 - ncbi_taxonomy - Decapoda + GC_ID:1 + ncbi_taxonomy + Decapoda @@ -3924,9 +3887,9 @@ - GC_ID:1 - ncbi_taxonomy - Pleocyemata + GC_ID:1 + ncbi_taxonomy + Pleocyemata @@ -3936,23 +3899,23 @@ - GC_ID:1 - short-tailed crabs - true crabs - ncbi_taxonomy - Brachyura + GC_ID:1 + short-tailed crabs + true crabs + ncbi_taxonomy + Brachyura - short-tailed crabs + short-tailed crabs - true crabs - + true crabs + @@ -3962,15 +3925,15 @@ - GC_ID:1 - rock crabs - ncbi_taxonomy - Cancridae + GC_ID:1 + rock crabs + ncbi_taxonomy + Cancridae - rock crabs + rock crabs @@ -3981,43 +3944,43 @@ - GC_ID:1 - insects - ncbi_taxonomy - Atelocerata - Tracheata - Uniramia - hexapods - Hexapoda + GC_ID:1 + insects + ncbi_taxonomy + Atelocerata + Tracheata + Uniramia + hexapods + Hexapoda - insects + insects - Atelocerata + Atelocerata - Tracheata + Tracheata - Uniramia + Uniramia - hexapods + hexapods @@ -4028,29 +3991,29 @@ - GC_ID:1 - butterflies and moths - moths - ncbi_taxonomy - moths - Lepidoptera + GC_ID:1 + butterflies and moths + moths + ncbi_taxonomy + moths + Lepidoptera - butterflies and moths + butterflies and moths - moths - + moths + - moths + moths @@ -4061,22 +4024,22 @@ - GC_ID:1 - flies - ncbi_taxonomy - flies - Diptera + GC_ID:1 + flies + ncbi_taxonomy + flies + Diptera - flies + flies - flies + flies @@ -4087,9 +4050,9 @@ - GC_ID:1 - ncbi_taxonomy - saccharomyceta + GC_ID:1 + ncbi_taxonomy + saccharomyceta @@ -4099,9 +4062,9 @@ - GC_ID:1 - ncbi_taxonomy - Brachycera + GC_ID:1 + ncbi_taxonomy + Brachycera @@ -4111,9 +4074,9 @@ - GC_ID:1 - ncbi_taxonomy - Eumalacostraca + GC_ID:1 + ncbi_taxonomy + Eumalacostraca @@ -4123,15 +4086,15 @@ - GC_ID:1 - pomace flies - ncbi_taxonomy - Drosophilidae + GC_ID:1 + pomace flies + ncbi_taxonomy + Drosophilidae - pomace flies + pomace flies @@ -4142,31 +4105,31 @@ - NCBITaxon:7326 - GC_ID:1 - Drosophila - fruit flies - fruit fly - ncbi_taxonomy - Drosophila <flies,genus> + NCBITaxon:7326 + GC_ID:1 + Drosophila + fruit flies + fruit fly + ncbi_taxonomy + Drosophila <flies,genus> - Drosophila + Drosophila - fruit flies + fruit flies - fruit fly - + fruit fly + @@ -4176,25 +4139,25 @@ - NCBITaxon:27522 - NCBITaxon:27527 - NCBITaxon:27531 - GC_ID:1 - hymenopterans - ncbi_taxonomy - hymenopterans - Hymenoptera + NCBITaxon:27522 + NCBITaxon:27527 + NCBITaxon:27531 + GC_ID:1 + hymenopterans + ncbi_taxonomy + hymenopterans + Hymenoptera - hymenopterans - + hymenopterans + - hymenopterans + hymenopterans @@ -4205,22 +4168,22 @@ - GC_ID:1 - wasps, ants & bees - ncbi_taxonomy - wasps, ants & bees - Apocrita + GC_ID:1 + wasps, ants & bees + ncbi_taxonomy + wasps, ants & bees + Apocrita - wasps, ants & bees + wasps, ants & bees - wasps, ants & bees + wasps, ants & bees @@ -4231,15 +4194,15 @@ - GC_ID:1 - Aculeata - ncbi_taxonomy - Aculeata <wasps, ants & bees> + GC_ID:1 + Aculeata + ncbi_taxonomy + Aculeata <wasps, ants & bees> - Aculeata + Aculeata @@ -4248,17 +4211,17 @@ - + - GC_ID:1 - bumble bees and honey bees - ncbi_taxonomy - Apidae + GC_ID:1 + bumble bees and honey bees + ncbi_taxonomy + Apidae - bumble bees and honey bees + bumble bees and honey bees @@ -4269,22 +4232,22 @@ - GC_ID:1 - Pterygota - winged insects - ncbi_taxonomy - Pterygota <insects> + GC_ID:1 + Pterygota + winged insects + ncbi_taxonomy + Pterygota <insects> - Pterygota + Pterygota - winged insects + winged insects @@ -4295,22 +4258,22 @@ - GC_ID:1 - chordates - ncbi_taxonomy - chordates - Chordata + GC_ID:1 + chordates + ncbi_taxonomy + chordates + Chordata - chordates + chordates - chordates + chordates @@ -4321,29 +4284,29 @@ - GC_ID:1 - Vertebrata - vertebrates - ncbi_taxonomy - vertebrates - Vertebrata <vertebrates> + GC_ID:1 + Vertebrata + vertebrates + ncbi_taxonomy + vertebrates + Vertebrata <vertebrates> - Vertebrata + Vertebrata - vertebrates + vertebrates - vertebrates + vertebrates @@ -4354,10 +4317,10 @@ - NCBITaxon:77729 - GC_ID:1 - ncbi_taxonomy - Daphniidae + NCBITaxon:77729 + GC_ID:1 + ncbi_taxonomy + Daphniidae @@ -4367,22 +4330,22 @@ - GC_ID:1 - Gnathostomata - jawed vertebrates - ncbi_taxonomy - Gnathostomata <vertebrates> + GC_ID:1 + Gnathostomata + jawed vertebrates + ncbi_taxonomy + Gnathostomata <vertebrates> - Gnathostomata + Gnathostomata - jawed vertebrates + jawed vertebrates @@ -4393,15 +4356,15 @@ - GC_ID:1 - euphyllophytes - ncbi_taxonomy - Euphyllophyta + GC_ID:1 + euphyllophytes + ncbi_taxonomy + Euphyllophyta - euphyllophytes + euphyllophytes @@ -4412,50 +4375,50 @@ - GC_ID:1 - fish - fishes - ray-finned fishes - ncbi_taxonomy - Actinopterygi - Osteichthyes - bony fishes - Actinopterygii + GC_ID:1 + fish + fishes + ray-finned fishes + ncbi_taxonomy + Actinopterygi + Osteichthyes + bony fishes + Actinopterygii - fish - + fish + - fishes - + fishes + - ray-finned fishes + ray-finned fishes - Actinopterygi + Actinopterygi - Osteichthyes + Osteichthyes - bony fishes + bony fishes @@ -4466,15 +4429,15 @@ - GC_ID:1 - carps and others - ncbi_taxonomy - Cypriniformes + GC_ID:1 + carps and others + ncbi_taxonomy + Cypriniformes - carps and others + carps and others @@ -4485,24 +4448,24 @@ - NCBITaxon:46777 - NCBITaxon:487617 - GC_ID:1 - ncbi_taxonomy - Brachydanio - Celestichthys - Danio + NCBITaxon:46777 + NCBITaxon:487617 + GC_ID:1 + ncbi_taxonomy + Brachydanio + Celestichthys + Danio - Brachydanio + Brachydanio - Celestichthys + Celestichthys @@ -4513,73 +4476,73 @@ - NCBITaxon:27702 - NCBITaxon:37966 - GC_ID:1 - leopard danio - zebra danio - zebra fish - zebrafish - ncbi_taxonomy - Brachydanio rerio - Brachydanio rerio frankei - Cyprinus rerio - Danio frankei - Danio rerio frankei - Danio rerio + NCBITaxon:27702 + NCBITaxon:37966 + GC_ID:1 + leopard danio + zebra danio + zebra fish + zebrafish + ncbi_taxonomy + Brachydanio rerio + Brachydanio rerio frankei + Cyprinus rerio + Danio frankei + Danio rerio frankei + Danio rerio - leopard danio - + leopard danio + - zebra danio - + zebra danio + - zebra fish - + zebra fish + - zebrafish + zebrafish - Brachydanio rerio + Brachydanio rerio - Brachydanio rerio frankei + Brachydanio rerio frankei - Cyprinus rerio + Cyprinus rerio - Danio frankei + Danio frankei - Danio rerio frankei + Danio rerio frankei @@ -4590,15 +4553,15 @@ - GC_ID:1 - salmons and trouts - ncbi_taxonomy - Salmoniformes + GC_ID:1 + salmons and trouts + ncbi_taxonomy + Salmoniformes - salmons and trouts + salmons and trouts @@ -4609,16 +4572,16 @@ - GC_ID:1 - PMID:15062801 - salmonids - ncbi_taxonomy - Salmonidae + GC_ID:1 + PMID:15062801 + salmonids + ncbi_taxonomy + Salmonidae - salmonids + salmonids @@ -4629,15 +4592,15 @@ - GC_ID:1 - ncbi_taxonomy - Parasalmo - Oncorhynchus + GC_ID:1 + ncbi_taxonomy + Parasalmo + Oncorhynchus - Parasalmo + Parasalmo @@ -4648,24 +4611,24 @@ - NCBITaxon:62064 - NCBITaxon:82302 - GC_ID:1 - ncbi_taxonomy - Acantholingua - Salmothymus - Salmo + NCBITaxon:62064 + NCBITaxon:82302 + GC_ID:1 + ncbi_taxonomy + Acantholingua + Salmothymus + Salmo - Acantholingua + Acantholingua - Salmothymus + Salmothymus @@ -4676,15 +4639,15 @@ - GC_ID:1 - flatfishes - ncbi_taxonomy - Pleuronectiformes + GC_ID:1 + flatfishes + ncbi_taxonomy + Pleuronectiformes - flatfishes + flatfishes @@ -4695,15 +4658,15 @@ - GC_ID:1 - righteye flounders - ncbi_taxonomy - Pleuronectidae + GC_ID:1 + righteye flounders + ncbi_taxonomy + Pleuronectidae - righteye flounders + righteye flounders @@ -4714,9 +4677,9 @@ - GC_ID:1 - ncbi_taxonomy - Sarcopterygii + GC_ID:1 + ncbi_taxonomy + Sarcopterygii @@ -4726,22 +4689,22 @@ - GC_ID:1 - amphibians - ncbi_taxonomy - amphibians - Amphibia + GC_ID:1 + amphibians + ncbi_taxonomy + amphibians + Amphibia - amphibians + amphibians - amphibians + amphibians @@ -4752,43 +4715,43 @@ - GC_ID:1 - anurans - frogs - frogs and toads - ncbi_taxonomy - Salientia - frogs & toads - Anura + GC_ID:1 + anurans + frogs + frogs and toads + ncbi_taxonomy + Salientia + frogs & toads + Anura - anurans - + anurans + - frogs - + frogs + - frogs and toads + frogs and toads - Salientia + Salientia - frogs & toads + frogs & toads @@ -4799,24 +4762,24 @@ - NCBITaxon:685149 - GC_ID:1 - riparian frogs - true frogs - ncbi_taxonomy - Ranidae + NCBITaxon:685149 + GC_ID:1 + riparian frogs + true frogs + ncbi_taxonomy + Ranidae - riparian frogs + riparian frogs - true frogs - + true frogs + @@ -4826,9 +4789,9 @@ - GC_ID:1 - ncbi_taxonomy - Neobatrachia + GC_ID:1 + ncbi_taxonomy + Neobatrachia @@ -4838,9 +4801,9 @@ - GC_ID:1 - ncbi_taxonomy - Diplostraca + GC_ID:1 + ncbi_taxonomy + Diplostraca @@ -4850,15 +4813,15 @@ - GC_ID:1 - sauropsids - ncbi_taxonomy - Sauropsida + GC_ID:1 + sauropsids + ncbi_taxonomy + Sauropsida - sauropsids + sauropsids @@ -4869,9 +4832,9 @@ - GC_ID:1 - ncbi_taxonomy - Archosauria + GC_ID:1 + ncbi_taxonomy + Archosauria @@ -4881,9 +4844,9 @@ - GC_ID:1 - ncbi_taxonomy - Dicondylia + GC_ID:1 + ncbi_taxonomy + Dicondylia @@ -4893,9 +4856,9 @@ - GC_ID:1 - ncbi_taxonomy - Artemia salina + GC_ID:1 + ncbi_taxonomy + Artemia salina @@ -4905,9 +4868,9 @@ - GC_ID:1 - ncbi_taxonomy - Amphiesmenoptera + GC_ID:1 + ncbi_taxonomy + Amphiesmenoptera @@ -4917,29 +4880,29 @@ - GC_ID:1 - birds - ncbi_taxonomy - avian - birds - Aves + GC_ID:1 + birds + ncbi_taxonomy + avian + birds + Aves - birds + birds - avian + avian - birds + birds @@ -4950,9 +4913,9 @@ - GC_ID:1 - ncbi_taxonomy - Neognathae + GC_ID:1 + ncbi_taxonomy + Neognathae @@ -4962,15 +4925,15 @@ - GC_ID:1 - ducks, geese and swans - ncbi_taxonomy - Anseriformes + GC_ID:1 + ducks, geese and swans + ncbi_taxonomy + Anseriformes - ducks, geese and swans + ducks, geese and swans @@ -4981,15 +4944,15 @@ - GC_ID:1 - waterfowl - ncbi_taxonomy - Anatidae + GC_ID:1 + waterfowl + ncbi_taxonomy + Anatidae - waterfowl + waterfowl @@ -5000,9 +4963,9 @@ - GC_ID:1 - ncbi_taxonomy - Panarthropoda + GC_ID:1 + ncbi_taxonomy + Panarthropoda @@ -5012,15 +4975,15 @@ - GC_ID:1 - Craniata - ncbi_taxonomy - Craniata <chordates> + GC_ID:1 + Craniata + ncbi_taxonomy + Craniata <chordates> - Craniata + Craniata @@ -5031,15 +4994,15 @@ - GC_ID:1 - landfowls - ncbi_taxonomy - Galliformes + GC_ID:1 + landfowls + ncbi_taxonomy + Galliformes - landfowls + landfowls @@ -5050,16 +5013,16 @@ - NCBITaxon:9099 - GC_ID:1 - turkeys - ncbi_taxonomy - Phasianidae + NCBITaxon:9099 + GC_ID:1 + turkeys + ncbi_taxonomy + Phasianidae - turkeys + turkeys @@ -5070,9 +5033,9 @@ - GC_ID:1 - ncbi_taxonomy - Gallus + GC_ID:1 + ncbi_taxonomy + Gallus @@ -5082,50 +5045,50 @@ - GC_ID:1 - Gallus domesticus - bantam - chicken - chickens - ncbi_taxonomy - Gallus gallus domesticus - Phasianus gallus - Gallus gallus + GC_ID:1 + Gallus domesticus + bantam + chicken + chickens + ncbi_taxonomy + Gallus gallus domesticus + Phasianus gallus + Gallus gallus - Gallus domesticus + Gallus domesticus - bantam - + bantam + - chicken + chicken - chickens - + chickens + - Gallus gallus domesticus + Gallus gallus domesticus - Phasianus gallus + Phasianus gallus @@ -5136,9 +5099,9 @@ - GC_ID:1 - ncbi_taxonomy - Phasianinae + GC_ID:1 + ncbi_taxonomy + Phasianinae @@ -5148,9 +5111,9 @@ - GC_ID:1 - ncbi_taxonomy - Enchytraeus crypticus + GC_ID:1 + ncbi_taxonomy + Enchytraeus crypticus @@ -5160,29 +5123,29 @@ - GC_ID:1 - whales, hippos, ruminants, pigs, camels etc. - ncbi_taxonomy - Cetartiodactyla - even-toed ungulates - Artiodactyla + GC_ID:1 + whales, hippos, ruminants, pigs, camels etc. + ncbi_taxonomy + Cetartiodactyla + even-toed ungulates + Artiodactyla - whales, hippos, ruminants, pigs, camels etc. + whales, hippos, ruminants, pigs, camels etc. - Cetartiodactyla + Cetartiodactyla - even-toed ungulates + even-toed ungulates @@ -5193,43 +5156,43 @@ - GC_ID:1 - eutherian mammals - placental mammals - placentals - ncbi_taxonomy - Placentalia - placentals - Eutheria + GC_ID:1 + eutherian mammals + placental mammals + placentals + ncbi_taxonomy + Placentalia + placentals + Eutheria - eutherian mammals - + eutherian mammals + - placental mammals - + placental mammals + - placentals + placentals - Placentalia + Placentalia - placentals + placentals @@ -5240,29 +5203,29 @@ - GC_ID:1 - primate - ncbi_taxonomy - Primata - primates - Primates + GC_ID:1 + primate + ncbi_taxonomy + Primata + primates + Primates - primate + primate - Primata + Primata - primates + primates @@ -5273,30 +5236,30 @@ - GC_ID:1 - New World monkeys - monkey - monkeys - ncbi_taxonomy - Platyrrhini + GC_ID:1 + New World monkeys + monkey + monkeys + ncbi_taxonomy + Platyrrhini - New World monkeys + New World monkeys - monkey - + monkey + - monkeys - + monkeys + @@ -5306,9 +5269,9 @@ - GC_ID:1 - ncbi_taxonomy - Catarrhini + GC_ID:1 + ncbi_taxonomy + Catarrhini @@ -5318,30 +5281,30 @@ - GC_ID:1 - Old World monkeys - monkey - monkeys - ncbi_taxonomy - Cercopithecidae + GC_ID:1 + Old World monkeys + monkey + monkeys + ncbi_taxonomy + Cercopithecidae - Old World monkeys + Old World monkeys - monkey - + monkey + - monkeys - + monkeys + @@ -5351,9 +5314,9 @@ - GC_ID:1 - ncbi_taxonomy - Cercopithecinae + GC_ID:1 + ncbi_taxonomy + Cercopithecinae @@ -5363,22 +5326,22 @@ - GC_ID:1 - macaque - macaques - ncbi_taxonomy - Macaca + GC_ID:1 + macaque + macaques + ncbi_taxonomy + Macaca - macaque - + macaque + - macaques + macaques @@ -5389,45 +5352,38 @@ - NCBITaxon:36502 - GC_ID:1 - Rhesus monkey - rhesus macaque - rhesus macaques - rhesus monkeys - ncbi_taxonomy - Cercopithecus mulatta - Macaca mulatta + NCBITaxon:36502 + GC_ID:1 + Rhesus monkey + rhesus macaque + rhesus macaques + rhesus monkeys + ncbi_taxonomy + Macaca mulatta - Rhesus monkey + Rhesus monkey - rhesus macaque - + rhesus macaque + - rhesus macaques - + rhesus macaques + - rhesus monkeys - - - - - - Cercopithecus mulatta - + rhesus monkeys + @@ -5437,22 +5393,22 @@ - GC_ID:1 - great apes - ncbi_taxonomy - Pongidae - Hominidae + GC_ID:1 + great apes + ncbi_taxonomy + Pongidae + Hominidae - great apes + great apes - Pongidae + Pongidae @@ -5463,16 +5419,16 @@ - GC_ID:1 - humans - ncbi_taxonomy - Homo + GC_ID:1 + humans + ncbi_taxonomy + Homo - humans - + humans + @@ -5482,15 +5438,15 @@ - GC_ID:1 - human - ncbi_taxonomy - Homo sapiens + GC_ID:1 + human + ncbi_taxonomy + Homo sapiens - human + human @@ -5501,15 +5457,15 @@ - GC_ID:1 - dog, coyote, wolf, fox - ncbi_taxonomy - Canidae + GC_ID:1 + dog, coyote, wolf, fox + ncbi_taxonomy + Canidae - dog, coyote, wolf, fox + dog, coyote, wolf, fox @@ -5520,9 +5476,9 @@ - GC_ID:1 - ncbi_taxonomy - Canis + GC_ID:1 + ncbi_taxonomy + Canis @@ -5532,17 +5488,17 @@ - NCBITaxon:68731 - NCBITaxon:9609 - GC_ID:1 - ncbi_taxonomy - Fennecus - Vulpes + NCBITaxon:68731 + NCBITaxon:9609 + GC_ID:1 + ncbi_taxonomy + Fennecus + Vulpes - Fennecus + Fennecus @@ -5553,15 +5509,15 @@ - GC_ID:1 - cat family - ncbi_taxonomy - Felidae + GC_ID:1 + cat family + ncbi_taxonomy + Felidae - cat family + cat family @@ -5572,9 +5528,9 @@ - GC_ID:1 - ncbi_taxonomy - Felis + GC_ID:1 + ncbi_taxonomy + Felis @@ -5584,47 +5540,47 @@ - NCBITaxon:36475 - GC_ID:1 - PMID:17600185 - PMID:8581300 - PMID:8603894 - cat - cats - domestic cat - ncbi_taxonomy - Felis domesticus - Felis silvestris catus - Felis catus + NCBITaxon:36475 + GC_ID:1 + PMID:17600185 + PMID:8581300 + PMID:8603894 + cat + cats + domestic cat + ncbi_taxonomy + Felis domesticus + Felis silvestris catus + Felis catus - cat - + cat + - cats - + cats + - domestic cat + domestic cat - Felis domesticus + Felis domesticus - Felis silvestris catus + Felis silvestris catus @@ -5635,23 +5591,23 @@ - NCBITaxon:39423 - GC_ID:1 - boars - pigs - ncbi_taxonomy - Suidae + NCBITaxon:39423 + GC_ID:1 + boars + pigs + ncbi_taxonomy + Suidae - boars - + boars + - pigs + pigs @@ -5662,9 +5618,9 @@ - GC_ID:1 - ncbi_taxonomy - Sus + GC_ID:1 + ncbi_taxonomy + Sus @@ -5674,9 +5630,9 @@ - GC_ID:1 - ncbi_taxonomy - Ruminantia + GC_ID:1 + ncbi_taxonomy + Ruminantia @@ -5686,15 +5642,15 @@ - GC_ID:1 - deer - ncbi_taxonomy - Cervidae + GC_ID:1 + deer + ncbi_taxonomy + Cervidae - deer + deer @@ -5705,9 +5661,9 @@ - GC_ID:1 - ncbi_taxonomy - Rangifer + GC_ID:1 + ncbi_taxonomy + Rangifer @@ -5717,9 +5673,9 @@ - GC_ID:1 - ncbi_taxonomy - Odocoileinae + GC_ID:1 + ncbi_taxonomy + Odocoileinae @@ -5729,9 +5685,9 @@ - GC_ID:1 - ncbi_taxonomy - Bovidae + GC_ID:1 + ncbi_taxonomy + Bovidae @@ -5741,15 +5697,15 @@ - GC_ID:1 - oxen, cattle - ncbi_taxonomy - Bos + GC_ID:1 + oxen, cattle + ncbi_taxonomy + Bos - oxen, cattle + oxen, cattle @@ -5760,72 +5716,79 @@ - NCBITaxon:272461 - GC_ID:1 - bovine - cattle - cow - dairy cow - domestic cattle - domestic cow - ox - ncbi_taxonomy - Bos bovis - Bos primigenius taurus - Bos taurus + NCBITaxon:272461 + GC_ID:1 + bovine + cattle + cow + dairy cow + domestic cattle + domestic cow + ox + oxen + ncbi_taxonomy + Bos bovis + Bos primigenius taurus + Bos taurus - bovine - + bovine + - cattle + cattle - cow - + cow + + + + + + dairy cow + - dairy cow - + domestic cattle + - domestic cattle - + domestic cow + - domestic cow - + ox + - ox - + oxen + - Bos bovis + Bos bovis - Bos primigenius taurus + Bos primigenius taurus @@ -5836,9 +5799,9 @@ - GC_ID:1 - ncbi_taxonomy - Ovis + GC_ID:1 + ncbi_taxonomy + Ovis @@ -5848,58 +5811,58 @@ - NCBITaxon:9936 - GC_ID:1 - domestic sheep - lambs - sheep - wild sheep - ncbi_taxonomy - Ovis ammon aries - Ovis orientalis aries - Ovis ovis - Ovis aries + NCBITaxon:9936 + GC_ID:1 + domestic sheep + lambs + sheep + wild sheep + ncbi_taxonomy + Ovis ammon aries + Ovis orientalis aries + Ovis ovis + Ovis aries - domestic sheep - + domestic sheep + - lambs - + lambs + - sheep + sheep - wild sheep - + wild sheep + - Ovis ammon aries + Ovis ammon aries - Ovis orientalis aries + Ovis orientalis aries - Ovis ovis + Ovis ovis @@ -5910,9 +5873,9 @@ - GC_ID:1 - ncbi_taxonomy - Caprinae + GC_ID:1 + ncbi_taxonomy + Caprinae @@ -5922,15 +5885,15 @@ - GC_ID:1 - ncbi_taxonomy - rabbits & hares - Lagomorpha + GC_ID:1 + ncbi_taxonomy + rabbits & hares + Lagomorpha - rabbits & hares + rabbits & hares @@ -5941,22 +5904,22 @@ - GC_ID:1 - rodent - ncbi_taxonomy - rodents - Rodentia + GC_ID:1 + rodent + ncbi_taxonomy + rodents + Rodentia - rodent + rodent - rodents + rodents diff --git a/src/ontology/imports/obi_import.owl b/src/ontology/imports/obi_import.owl index 148b082..0bdbf1d 100644 --- a/src/ontology/imports/obi_import.owl +++ b/src/ontology/imports/obi_import.owl @@ -11,9 +11,9 @@ xmlns:terms="http://purl.org/dc/terms/" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - - 2023-12-18 + + + 2023-07-06 @@ -532,7 +532,7 @@ Werner suggests a solution based on "Magnitudes" a proposal for which is_supported_by_data - The relation between the conclusion "Gene tpbA is involved in EPS production" and the data items produced using two sets of organisms, one being a tpbA knockout, the other being tpbA wildtype tested in polysacharide production assays and analyzed using an ANOVA. + The relation between the conclusion "Gene tpbA is involved in EPS production" and the data items produced using two sets of organisms, one being a tpbA knockout, the other being tpbA wildtype tested in polysacharide production assays and analyzed using an ANOVA. The relation between a data item and a conclusion where the conclusion is the output of a data interpreting process and the data item is used as an input to that process OBI @@ -614,6 +614,11 @@ Werner suggests a solution based on "Magnitudes" a proposal for which + + + + + is_specified_output_of @@ -788,21 +793,6 @@ Werner suggests a solution based on "Magnitudes" a proposal for which - - - - - - this red color is a quality of this apple - a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence - A quality inheres in its bearer at all times for which the quality exists. - is quality of - quality_of - quality of - - - - @@ -833,20 +823,6 @@ Werner suggests a solution based on "Magnitudes" a proposal for which - - - - - - this apple has quality this red color - a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence - A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist. - has_quality - has quality - - - - @@ -1623,6 +1599,7 @@ Werner suggests a solution based on "Magnitudes" a proposal for which material MaterialEntity + material entity material entity a flame a forest fire @@ -1640,7 +1617,6 @@ Werner suggests a solution based on "Magnitudes" a proposal for which BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60 BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity. BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here. - A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002]) @@ -1650,6 +1626,7 @@ Werner suggests a solution based on "Magnitudes" a proposal for which (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] + material entity material entity @@ -1727,10 +1704,12 @@ Werner suggests a solution based on "Magnitudes" a proposal for which cell + cell PMID:18089833.Cancer Res. 2007 Dec 15;67(24):12018-25. "...Epithelial cells were harvested from histologically confirmed adenocarcinomas .." A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. cell + cell @@ -1891,7 +1870,6 @@ JAR: A data item is an approximately justified approximately true approximate be PERSON: Chris Stoeckert PERSON: Jonathan Rees data - data item @@ -1917,7 +1895,6 @@ JAR: A data item is an approximately justified approximately true approximate be Previous. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity. PERSON: Chris Stoeckert OBI_0000142 - information content entity @@ -2534,23 +2511,10 @@ clustering algorithm. - - - - - Metazoa - metazoans - multicellular animals - - Metazoa - - - - - + Bilateria Bilateria @@ -2590,6 +2554,7 @@ clustering algorithm. Homo sapiens human human being + man Homo sapiens @@ -2880,7 +2845,7 @@ for now. interpreting data - Concluding that a gene is upregulated in a tissue sample based on the band intensity in a western blot. Concluding that a patient has a infection based on measurement of an elevated body temperature and reported headache. Concluding that there were problems in an investigation because data from PCR and microarray are conflicting. Concluding that 'defects in gene XYZ cause cancer due to improper DNA repair' based on data from experiments in that study that gene XYZ is involved in DNA repair, and the conclusion of a previous study that cancer patients have an increased number of mutations in this gene. + Concluding that a gene is upregulated in a tissue sample based on the band intensity in a western blot. Concluding that a patient has a infection based on measurement of an elevated body temperature and reported headache. Concluding that there were problems in an investigation because data from PCR and microarray are conflicting. Concluding that 'defects in gene XYZ cause cancer due to improper DNA repair' based on data from experiments in that study that gene XYZ is involved in DNA repair, and the conclusion of a previous study that cancer patients have an increased number of mutations in this gene. A planned process in which data gathered in an investigation is evaluated in the context of existing knowledge with the objective to generate more general conclusions or to conclude that the data does not allow one to draw general conclusion PERSON: Bjoern Peters @@ -2993,8 +2958,7 @@ for now. manufacturing - A planned process with the objective to produce a processed material which will have a function for future use. - A person or organization (having manufacturer role) is a participant in this process + Manufacturing is a process with the intent to produce a processed material which will have a function for future use. A person or organization (having manufacturer role) is a participant in this process Manufacturing implies reproducibility and responsibility AR This includes a single scientist making a processed material for personal use. PERSON: Bjoern Peters @@ -3358,7 +3322,7 @@ http://sourceforge.net/p/obi/obi-terms/716/ manufacturer - A person or organization that has a manufacturer role. + A person or organization that has a manufacturer role manufacturer @@ -3428,7 +3392,7 @@ A blood specimen that has been centrifuged to obtain the white blood cells. categorical label - The labels 'positive' vs. 'negative', or 'left handed', 'right handed', 'ambidexterous', or 'strongly binding', 'weakly binding' , 'not binding', or '+++', '++', '+', '-' etc. form scales of categorical labels. + The labels 'positive' vs. 'negative', or 'left handed', 'right handed', 'ambidexterous', or 'strongly binding', 'weakly binding' , 'not binding', or '+++', '++', '+', '-' etc. form scales of categorical labels. A label that is part of a categorical datum and that indicates the value of the data item on the categorical scale. Bjoern Peters @@ -3469,7 +3433,7 @@ A blood specimen that has been centrifuged to obtain the white blood cells. +In the examples above, a reagent is an operational component of a device, but the device itself does not realize a reagent role (as bearing a reagent role is not transitive across the part_of relation). In this way, the asserted disjointness between a reagent and device holds, as both roles are never realized in the same bearer during execution of an assay. PERSON: Helen Parkinson instrument OBI development call 2012-12-17. @@ -3499,7 +3463,7 @@ In the examples above, a reagent is an operational component of a device, but th A document with a set of printed or written questions with a choice of answers, devised for the purposes of a survey or statistical study. JT: It plays a role in collecting data that could be fleshed out more; but I'm thinking it is, in itself, an edited document. -JZ: based on textual definition of edited document, it can be defined as N&S. I prefer to leave questionnaire as a document now. We can add more restrictions in the future and use that to determine it is an edited document or not. +JZ: based on textual definition of edited document, it can be defined as N&S. I prefer to leave questionnaire as a document now. We can add more restrictions in the future and use that to determine it is an edited document or not. Need to clarify if this is a document or a directive information entity (or what their connection is)) PERSON: Jessica Turner Merriam-Webster @@ -3576,7 +3540,7 @@ JZ: based on textual definition of edited document, it can be defined as N&S The following are NOT conclusions based on data: data themselves; results from pure mathematics, e.g. "13 is prime". An information content entity that is inferred from data. - In the Philly 2013 workshop, we recognized the limitations of "conclusion textual entity", and we introduced this as more general. The need for the 'textual entity' term going forward is up for future debate. + In the Philly 2013 workshop, we recognized the limitations of "conclusion textual entity", and we introduced this as more general. The need for the 'textual entity' term going forward is up for future debate. Group:2013 Philly Workshop group Group:2013 Philly Workshop group conclusion based on data @@ -3719,7 +3683,7 @@ The following are NOT conclusions based on data: data themselves; results from p histologic grade for ovarian tumor according to a two-tier grading system - A histologic grade for ovarian tumor that is from a two-tier histological classification of tumors. + A histologic grade for ovarian tumor that is from a two-tier histological classification of tumors. Chris Stoeckert, Helena Ellis NCI BBRB, OBI NCI BBRB @@ -4382,7 +4346,7 @@ This issue is outside the scope of OBI. data visualization Generation of a heatmap from a microarray dataset - A planned process with the objective to graphically represent some data by inputing the data and outputting images, diagrams or animations. + An planned process that creates images, diagrams or animations from the input data. Elisabetta Manduchi James Malone Melanie Courtot @@ -4592,13 +4556,13 @@ class labels for these objects. The resulting predictor can be used to attach cl - planned irradiation + irradiation PMID: 18563778.Histological and modeling study of skin thermal injury to 2.0 mum laser irradiation.Lasers Surg Med. 2008 Jun 18;40(5):358-370. - A planned process by which a material entity is exposed to radiative energy, which could be ionizing radiation (such as gamma rays, X-rays, charged particles or neutrons) or non-ionizing radiation (such as UV light or microwaves) + irradiation is a process by which a material entity is exposed to radiative energy, which could be ionizing radiation (such as gamma rays or X-rays) or not such as UV light or microwaves Philippe Rocca-Serra adapted from wikipedia (http://en.wikipedia.org/wiki/Irradiation) - planned irradiation + irradiation @@ -5634,7 +5598,7 @@ class labels for these objects. The resulting predictor can be used to attach cl Edingburgh handedness inventory - The Edinburgh Handedness Inventory is a set of questions used to assess the dominance of a person's right or left hand in everyday activities. + The Edinburgh Handedness Inventory is a set of questions used to assess the dominance of a person's right or left hand in everyday activities. PERSON:Alan Ruttenberg PERSON:Jessica Turner PMID:5146491#Oldfield, R.C. (1971). The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia, 9, 97-113 @@ -7346,7 +7310,7 @@ class labels for these objects. The resulting predictor can be used to attach cl Stage 0 (AJCC 7th) - A clinical tumor stage group according to AJCC 7th edition indicating a carcinoma in situ (or melanoma in situ for melanoma of the skin or germ cell neoplasia in situ for testicular germ cell tumors) and generally is considered to have no metastatic potential. + A clinical tumor stage group according to AJCC 7th edition indicating a carcinoma in situ (or melanoma in situ for melanoma of the skin or germ cell neoplasia in situ for testicular germ cell tumors) and generally is considered to have no metastatic potential. Chris Stoeckert, Helena Ellis Stage 0 https://en.wikipedia.org/wiki/Cancer_staging @@ -7602,7 +7566,7 @@ class labels for these objects. The resulting predictor can be used to attach cl Stage IIA (FIGO) - An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina without parametrial invasion. + An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina without parametrial invasion. Chris Stoeckert, Helena Ellis Stage IIA https://en.wikipedia.org/wiki/Cervical_cancer_staging @@ -7618,7 +7582,7 @@ class labels for these objects. The resulting predictor can be used to attach cl Stage IIA1 (FIGO) - An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina without parametrial invasion and clinically visible lesion <4.0 cm in greatest dimension. + An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina without parametrial invasion and clinically visible lesion <4.0 cm in greatest dimension. Chris Stoeckert, Helena Ellis Stage IIA1 https://en.wikipedia.org/wiki/Cervical_cancer_staging @@ -7634,7 +7598,7 @@ class labels for these objects. The resulting predictor can be used to attach cl Stage IIA2 (FIGO) - An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina without parametrial invasion and clinically visible lesion >4.0 cm in greatest dimension. + An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina without parametrial invasion and clinically visible lesion >4.0 cm in greatest dimension. Chris Stoeckert, Helena Ellis Stage IIA2 https://en.wikipedia.org/wiki/Cervical_cancer_staging @@ -7650,7 +7614,7 @@ class labels for these objects. The resulting predictor can be used to attach cl Stage IIB (FIGO) - An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina with obvious parametrial invasion. + An International Federation of Gynecology and Obstetrics cervical cancer stage value specification indicating cervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina with obvious parametrial invasion. Chris Stoeckert, Helena Ellis Stage IIB https://en.wikipedia.org/wiki/Cervical_cancer_staging @@ -8111,51 +8075,6 @@ class labels for these objects. The resulting predictor can be used to attach cl - - - - - Abbott - - A manufacturer of rapid point-of-care assay devices. - John Judkins ORCID:0000-0001-6595-0902 - WEB:https://www.globalpointofcare.abbott/en/about.html - https://github.com/obi-ontology/obi/issues/1456 - Abbott - - - - - - - - - J. Mitra - - A manufacturer of in vitro diagnostic assay kits in India. - John Judkins ORCID:0000-0001-6595-0902 - WEB:https://jmitra.co.in/about-us/ - https://github.com/obi-ontology/obi/issues/1456 - J. Mitra - - - - - - - - - InBios - - A manufacturer that specializes in in vitro diagnostic devices designed to test for infectious diseases. - John Judkins ORCID:0000-0001-6595-0902 - WEB:https://inbios.com/about/ - https://github.com/obi-ontology/obi/issues/1456 - InBios - - - - diff --git a/src/ontology/imports/pato_import.owl b/src/ontology/imports/pato_import.owl index 76c6adf..41abd20 100644 --- a/src/ontology/imports/pato_import.owl +++ b/src/ontology/imports/pato_import.owl @@ -24,8 +24,8 @@ xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#" xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#"> - - 2023-12-18 + + 2022-10-20 @@ -127,12 +127,6 @@ - - - - - - @@ -147,12 +141,6 @@ - - - - - - @@ -195,12 +183,6 @@ - - - - - - @@ -495,22 +477,6 @@ - - - - - - - - - - - - - - - - @@ -546,38 +512,12 @@ - - - - http://purl.org/dc/elements/1.1/description - uberon - dc-description - true - dc-description - description - - - - - - - - http://purl.org/dc/elements/1.1/title - uberon - dc-title - true - dc-title - title - - - - @@ -590,19 +530,6 @@ - - - - http://purl.org/dc/terms/license - uberon - dcterms-license - true - dcterms-license - license - - - - @@ -633,12 +560,6 @@ - - - - - - @@ -945,6 +866,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. participates_in participates in participates in + participates_in @@ -1283,6 +1205,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) immediately preceded by immediately preceded by + immediately_preceded_by @@ -1295,7 +1218,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - David Osumi-Sutherland ends_at_start_of meets @@ -1306,8 +1228,8 @@ A continuant cannot have an occurrent as part: use 'participates in'. immediately_precedes X immediately_precedes_Y iff: end(X) simultaneous_with start(Y) - immediately precedes immediately precedes + immediately_precedes @@ -1370,7 +1292,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. The original intent was to treat this as a macro that expands to 'in taxon' only ?Y - however, this is not necessary if we instead have supplemental axioms that state that each pair of sibling tax have a disjointness axiom using the 'in taxon' property - e.g. 'in taxon' some Eukaryota DisjointWith 'in taxon' some Eubacteria - + Chris Mungall RO:0002160 @@ -1413,8 +1335,8 @@ A continuant cannot have an occurrent as part: use 'participates in'. x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed. - - + Chris Mungall + Jennifer Deegan RO:0002162 @@ -1471,10 +1393,12 @@ A continuant cannot have an occurrent as part: use 'participates in'. - p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q. - - - + + process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2. + We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit + Chris Mungall + David Hill + Tanya Berardini GO Regulation precludes parthood; the regulatory process may not be within the regulated process. @@ -1503,8 +1427,8 @@ A continuant cannot have an occurrent as part: use 'participates in'. - p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q. - + Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2. + Chris Mungall negatively regulates (process to process) @@ -1536,8 +1460,8 @@ A continuant cannot have an occurrent as part: use 'participates in'. - p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q. - + Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2. + Chris Mungall positively regulates (process to process) @@ -1558,12 +1482,13 @@ A continuant cannot have an occurrent as part: use 'participates in'. + mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974) osteoclast SubClassOf 'capable of' some 'bone resorption' A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. - + Chris Mungall has function realized in @@ -1590,7 +1515,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. - + Chris Mungall has function in RO:0002216 external @@ -1619,7 +1544,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. - + Chris Mungall Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends. https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1 @@ -1638,7 +1563,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of starts with - Chris Mungall Allen RO:0002223 @@ -1661,7 +1585,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. - Chris Mungall started by RO:0002224 @@ -1684,7 +1607,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of ends with - Chris Mungall RO:0002229 uberon @@ -1705,7 +1627,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. - Chris Mungall finished by RO:0002230 @@ -1732,7 +1653,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p. - + Chris Mungall consumes RO:0002233 external @@ -1759,7 +1680,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p. - + Chris Mungall produces RO:0002234 external @@ -1816,9 +1737,9 @@ A continuant cannot have an occurrent as part: use 'participates in'. - p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss). + p results in the developmental progression of s iff p is a developmental process and s is an anatomical structure and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss). This property and its subproperties are being used primarily for the definition of GO developmental processes. The property hierarchy mirrors the core GO hierarchy. In future we may be able to make do with a more minimal set of properties, but due to the way GO is currently structured we require highly specific relations to avoid incorrect entailments. To avoid this, the corresponding genus terms in GO should be declared mutually disjoint. - + Chris Mungall RO:0002295 external results_in_developmental_progression_of @@ -1839,7 +1760,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. an annotation of gene X to anatomical structure formation with results_in_formation_of UBERON:0000007 (pituitary gland) means that at the beginning of the process a pituitary gland does not exist and at the end of the process a pituitary gland exists. every "endocardial cushion formation" (GO:0003272) results_in_formation_of some "endocardial cushion" (UBERON:0002062) - + Chris Mungall GOC:mtg_berkeley_2013 RO:0002297 external @@ -1859,9 +1780,8 @@ A continuant cannot have an occurrent as part: use 'participates in'. - p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q. - + cjm RO:0002304 external causally_upstream_of,_positive_effect @@ -1879,15 +1799,13 @@ A continuant cannot have an occurrent as part: use 'participates in'. - p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q. - + cjm RO:0002305 external causally_upstream_of,_negative_effect - - causally_upstream_of,_negative_effect + holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y causally upstream of, negative effect @@ -1907,7 +1825,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w. Because part_of is transitive, inheres in is a sub-relation of characteristic of part of - + Chris Mungall inheres in part of @@ -1930,7 +1848,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. A relationship that holds via some environmental process - + Chris Mungall Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the process of evolution. evolutionarily related to @@ -1941,7 +1859,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. A mereological relationship or a topological relationship - + Chris Mungall Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships mereotopologically related to @@ -1953,7 +1871,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. A relationship that holds between entities participating in some developmental process (GO:0032502) - + Chris Mungall Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving organismal development developmentally related to @@ -1974,8 +1892,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. a particular instances of akt-2 enables some instance of protein kinase activity - c enables p iff c is capable of p and c acts to execute p. - + Chris Mungall catalyzes executes has @@ -1992,7 +1909,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities. - + Chris Mungall This is a grouping relation that collects relations used for the purpose of connecting structure and function RO:0002328 uberon @@ -2013,7 +1930,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. this relation holds between c and p when c is part of some c', and c' is capable of p. - + Chris Mungall false part of structure that is capable of @@ -2043,7 +1960,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. c involved_in p if and only if c enables some process p', and p' is part of p - + Chris Mungall actively involved in enables part of involved in @@ -2058,7 +1975,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of enables - + Chris Mungall enabled by @@ -2073,7 +1990,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of regulates - + Chris Mungall regulated by (processual) RO:0002334 external @@ -2091,7 +2008,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of negatively regulates - + Chris Mungall RO:0002335 external negatively_regulated_by @@ -2108,7 +2025,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of positively regulates - + Chris Mungall RO:0002336 external positively_regulated_by @@ -2126,7 +2043,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of has input - + Chris Mungall RO:0002352 uberon input_of @@ -2145,7 +2062,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of has output - + Chris Mungall RO:0002353 external uberon @@ -2163,7 +2080,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. - + Chris Mungall formed as result of @@ -2177,7 +2094,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of upstream of - + Chris Mungall RO:0002404 external causally_downstream_of @@ -2195,7 +2112,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. - + Chris Mungall RO:0002405 external immediately_causally_downstream_of @@ -2206,75 +2123,18 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - - - - - - - - - - - - - - - - - - - - p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q. - - indirectly activates - - indirectly positively regulates - - - - - - - - - - - - - - - - - - - - - - - p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q. - - indirectly inhibits - - indirectly negatively regulates - - - - - relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause. + + This relation groups causal relations between material entities and causal relations between processes This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents. To define causal relations in an activity-flow type network, we make use of 3 primitives: * Temporal: how do the intervals of the two occurrents relate? * Is the causal relation regulatory? - * Is the influence positive or negative? + * Is the influence positive or negative The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified. @@ -2283,16 +2143,10 @@ For the second, we consider a relationship to be regulatory if the system in whi For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral. Each of these 3 primitives can be composed to yield a cross-product of different relation types. - + Chris Mungall Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. causally related to - - - - relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause. - https://en.wikipedia.org/wiki/Causality - @@ -2302,8 +2156,9 @@ Each of these 3 primitives can be composed to yield a cross-product of different - p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q. - + + p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain + Chris Mungall RO:0002411 external causally_upstream_of @@ -2321,8 +2176,9 @@ Each of these 3 primitives can be composed to yield a cross-product of different - p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q. - + + p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q. + Chris Mungall RO:0002412 external @@ -2340,9 +2196,9 @@ Each of these 3 primitives can be composed to yield a cross-product of different - p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q. + p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q. We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2 - + Chris Mungall influences (processual) RO:0002418 external @@ -2360,7 +2216,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different inverse of causally upstream of or within - + Chris Mungall RO:0002427 external @@ -2386,7 +2242,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different c involved in regulation of p if c is involved in some p' and p' regulates some p - + Chris Mungall involved in regulation of @@ -2405,7 +2261,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different c involved in regulation of p if c is involved in some p' and p' positively regulates some p - + Chris Mungall involved in positive regulation of @@ -2425,7 +2281,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different c involved in regulation of p if c is involved in some p' and p' negatively regulates some p - + Chris Mungall involved in negative regulation of @@ -2440,7 +2296,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p OWL does not allow defining object properties via a Union - + Chris Mungall involved in or reguates involved in or involved in regulation of @@ -2456,7 +2312,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different A relationship that holds between two entities in which the processes executed by the two entities are causally connected. Considering relabeling as 'pairwise interacts with' This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact. - + Chris Mungall Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules. in pairwise interaction with @@ -2473,7 +2329,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other. - + Chris Mungall binds molecularly binds with molecularly interacts with @@ -2488,7 +2344,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different Axiomatization to GO to be added later - + Chris Mungall An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y. phosphorylates @@ -2510,8 +2366,8 @@ Each of these 3 primitives can be composed to yield a cross-product of different The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B. - - + Chris Mungall + Vasundra Touré molecularly controls directly regulates activity of @@ -2531,8 +2387,8 @@ A and B can be physically interacting but not necessarily. Immediately upstream The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B. - - + Chris Mungall + Vasundra Touré directly inhibits molecularly decreases activity of directly negatively regulates activity of @@ -2553,8 +2409,8 @@ For example, A and B may be gene products and binding of B by A negatively regul The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B. - - + Chris Mungall + Vasundra Touré directly activates molecularly increases activity of directly positively regulates activity of @@ -2565,7 +2421,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + Chris Mungall This property or its subproperties is not to be used directly. These properties exist as helper properties that are used to support OWL reasoning. helper property (not for use in curation) @@ -2576,7 +2432,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + Chris Mungall is kinase activity @@ -2587,7 +2443,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + Chris Mungall Do not use this relation directly. It is ended as a grouping for a diverse set of relations, typically connecting an anatomical entity to a biological process or developmental stage. relation between physical entity and a process or stage @@ -2599,7 +2455,7 @@ For example, A and B may be gene products and binding of B by A positively regul x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y)) - + Chris Mungall The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. existence overlaps @@ -2617,7 +2473,7 @@ For example, A and B may be gene products and binding of B by A positively regul Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely. x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y). - + Chris Mungall RO:0002492 ceases_to_exist_during uberon @@ -2640,7 +2496,7 @@ For example, A and B may be gene products and binding of B by A positively regul x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y). - + Chris Mungall RO:0002493 uberon existence_ends_with @@ -2668,7 +2524,7 @@ For example, A and B may be gene products and binding of B by A positively regul x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends. - + Chris Mungall RO:0002497 uberon existence_ends_during_or_before @@ -2697,8 +2553,8 @@ For example, A and B may be gene products and binding of B by A positively regul - p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q. - + p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q. + Chris Mungall Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. causal relation between processes @@ -2709,7 +2565,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + Chris Mungall depends on @@ -2723,7 +2579,7 @@ For example, A and B may be gene products and binding of B by A positively regul The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch - + Chris Mungall Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. causal relation between entities @@ -2736,7 +2592,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + Chris Mungall causally influenced by (entity-centric) causally influenced by @@ -2748,7 +2604,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + Chris Mungall interaction relation helper property http://purl.obolibrary.org/obo/ro/docs/interaction-relations/ @@ -2760,7 +2616,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + Chris Mungall molecular interaction relation helper property @@ -2783,8 +2639,8 @@ For example, A and B may be gene products and binding of B by A positively regul The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size). - - + Chris Mungall + Vasundra Touré causally influences (entity-centric) causally influences @@ -2797,18 +2653,14 @@ For example, A and B may be gene products and binding of B by A positively regul - p directly regulates q iff p is immediately causally upstream of q and p regulates q. - + Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. + Chris Mungall directly regulates (processual) - RO:0002578 - external - directly_regulates - directly_regulates directly regulates @@ -2825,7 +2677,7 @@ For example, A and B may be gene products and binding of B by A positively regul gland SubClassOf 'has part structure that is capable of' some 'secretion by cell' s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p - + Chris Mungall has part structure that is capable of @@ -2854,6 +2706,7 @@ For example, A and B may be gene products and binding of B by A positively regul results_in_assembly_of results in assembly of + results_in_assembly_of @@ -2868,6 +2721,7 @@ For example, A and B may be gene products and binding of B by A positively regul results_in_disassembly_of results_in_disassembly_of results in disassembly of + results_in_disassembly_of @@ -2895,7 +2749,7 @@ For example, A and B may be gene products and binding of B by A positively regul A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity. Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. - + Chris Mungall causal relation between material entity and a process @@ -2969,17 +2823,13 @@ For example, A and B may be gene products and binding of B by A positively regul - p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q. + Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2. directly positively regulates (process to process) - RO:0002629 - external - directly_positively_regulates - directly_positively_regulates directly positively regulates @@ -2990,17 +2840,13 @@ For example, A and B may be gene products and binding of B by A positively regul - p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q. + Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2. directly negatively regulates (process to process) - RO:0002630 - external - directly_negatively_regulates - directly_negatively_regulates directly negatively regulates @@ -3011,7 +2857,7 @@ For example, A and B may be gene products and binding of B by A positively regul p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c. - + cjm 2018-12-13T11:26:17Z RO:0004007 external @@ -3029,7 +2875,7 @@ For example, A and B may be gene products and binding of B by A positively regul p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c. - + cjm 2018-12-13T11:26:32Z RO:0004008 external @@ -3060,7 +2906,7 @@ For example, A and B may be gene products and binding of B by A positively regul Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P. - + cjm 2018-01-25T23:20:13Z enables subfunction @@ -3076,7 +2922,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + cjm 2018-01-26T23:49:30Z acts upstream of or within, positive effect @@ -3094,7 +2940,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + cjm 2018-01-26T23:49:51Z acts upstream of or within, negative effect @@ -3113,7 +2959,7 @@ For example, A and B may be gene products and binding of B by A positively regul c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive - + cjm 2018-01-26T23:53:14Z acts upstream of, positive effect @@ -3133,7 +2979,7 @@ For example, A and B may be gene products and binding of B by A positively regul c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative - + cjm 2018-01-26T23:53:22Z acts upstream of, negative effect @@ -3147,7 +2993,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + cjm 2018-03-13T23:55:05Z causally upstream of or within, negative effect @@ -3159,7 +3005,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + cjm 2018-03-13T23:55:19Z causally upstream of or within, positive effect @@ -3173,37 +3019,12 @@ For example, A and B may be gene products and binding of B by A positively regul The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B. - + Vasundra Touré regulates activity of - - - - - p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q. - pg - 2022-09-26T06:07:17Z - indirectly causally upstream of - - - - - - - - - - p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q. - pg - 2022-09-26T06:08:01Z - indirectly regulates - - - - @@ -3249,8 +3070,8 @@ For example, A and B may be gene products and binding of B by A positively regul A diagnostic testing device utilizes a specimen. X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y. - - + https://orcid.org/0000-0001-9625-1899 + https://orcid.org/0000-0003-2620-0345 A diagnostic testing device utilizes a specimen means that the diagnostic testing device is capable of an assay, and this assay a specimen as its input. See github ticket https://github.com/oborel/obo-relations/issues/497 2021-11-08T12:00:00Z @@ -3328,12 +3149,8 @@ For example, A and B may be gene products and binding of B by A positively regul p has anatomical participant c iff p has participant c, and c is an anatomical entity - + cjm 2018-09-26T01:08:58Z - RO:0040036 - external - results_in_changes_to_anatomical_or_cellular_structure - results_in_changes_to_anatomical_or_cellular_structure results in changes to anatomical or cellular structure @@ -3375,12 +3192,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - - @@ -11712,7 +11523,6 @@ For example, A and B may be gene products and binding of B by A positively regul - @@ -11963,7 +11773,7 @@ For example, A and B may be gene products and binding of B by A positively regul - A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. + A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process. GO:0005554 molecular function molecular_function @@ -11980,7 +11790,7 @@ For example, A and B may be gene products and binding of B by A positively regul - A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. + A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process. GOC:pdt @@ -12283,7 +12093,6 @@ For example, A and B may be gene products and binding of B by A positively regul The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. - GO:0005887 GO:0005904 juxtamembrane NIF_Subcellular:sao1663586795 @@ -12294,8 +12103,6 @@ For example, A and B may be gene products and binding of B by A positively regul plasmalemma bacterial inner membrane inner endospore membrane - integral component of plasma membrane - integral to plasma membrane plasma membrane lipid bilayer cellular_component GO:0005886 @@ -12484,8 +12291,8 @@ For example, A and B may be gene products and binding of B by A positively regul - + @@ -12588,7 +12395,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + @@ -12705,14 +12512,13 @@ For example, A and B may be gene products and binding of B by A positively regul - The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. - https://github.com/geneontology/go-ontology/issues/17904 + The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. GO:0006519 - cellular amino acid metabolic process + amino acid and derivative metabolism + amino acid metabolic process + cellular amino acid and derivative metabolic process cellular amino acid metabolism biological_process - amino acid and derivative metabolism - cellular amino acid and derivative metabolic process GO:0006520 @@ -12721,12 +12527,12 @@ For example, A and B may be gene products and binding of B by A positively regul - amino acid metabolic process + cellular amino acid metabolic process - The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. + The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. ISBN:0198506732 @@ -13157,8 +12963,7 @@ For example, A and B may be gene products and binding of B by A positively regul - A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. - https://github.com/geneontology/go-ontology/issues/24968 + A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. jl 2012-09-19T15:05:24Z GO:0000004 @@ -13184,7 +12989,7 @@ For example, A and B may be gene products and binding of B by A positively regul - A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. + A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. GOC:pdt @@ -13249,16 +13054,15 @@ For example, A and B may be gene products and binding of B by A positively regul The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. - https://github.com/geneontology/go-ontology/issues/17904 Wikipedia:Amino_acid_synthesis - amino acid anabolism - amino acid biosynthesis - amino acid formation - amino acid synthesis - cellular amino acid biosynthetic process + amino acid biosynthetic process + cellular amino acid anabolism + cellular amino acid biosynthesis + cellular amino acid formation + cellular amino acid synthesis biological_process GO:0008652 - amino acid biosynthetic process + cellular amino acid biosynthetic process @@ -13325,7 +13129,6 @@ For example, A and B may be gene products and binding of B by A positively regul The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - http://amigo.geneontology.org/amigo/term/GO:0070589 GO:0043284 biopolymer biosynthetic process macromolecule anabolism @@ -13512,7 +13315,6 @@ For example, A and B may be gene products and binding of B by A positively regul GO:0009987 - This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. cellular process @@ -13789,20 +13591,15 @@ For example, A and B may be gene products and binding of B by A positively regul - A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. + A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. 2014-03-06T11:37:54Z - GO:0016021 GO:0098589 GO:0098805 Wikipedia:Biological_membrane - Wikipedia:Transmembrane_protein - integral component of membrane - integral to membrane membrane region region of membrane whole membrane cellular_component - transmembrane GO:0016020 @@ -13816,17 +13613,11 @@ For example, A and B may be gene products and binding of B by A positively regul - A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. + A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. GOC:dos GOC:mah ISBN:0815316194 - - - - transmembrane - GOC:mah - @@ -14445,11 +14236,11 @@ For example, A and B may be gene products and binding of B by A positively regul The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. RNA-protein complex assembly RNP complex assembly - ribonucleoprotein complex assembly + protein-RNA complex assembly biological_process GO:0022618 - protein-RNA complex assembly + ribonucleoprotein complex assembly @@ -14672,7 +14463,6 @@ For example, A and B may be gene products and binding of B by A positively regul dsRNA biosynthetic process biological_process GO:0032774 - Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. RNA biosynthetic process @@ -14762,13 +14552,12 @@ For example, A and B may be gene products and binding of B by A positively regul The disaggregation of a protein-RNA complex into its constituent components. - https://github.com/geneontology/go-ontology/issues/25143 RNA-protein complex disassembly RNP complex disassembly - ribonucleoprotein complex disassembly + protein-RNA complex disassembly biological_process GO:0032988 - protein-RNA complex disassembly + ribonucleoprotein complex disassembly @@ -14783,7 +14572,12 @@ For example, A and B may be gene products and binding of B by A positively regul - + + + + + + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. GO:0043234 @@ -14833,6 +14627,62 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. + GO:0034961 + cellular biopolymer biosynthetic process + cellular macromolecule anabolism + cellular macromolecule biosynthesis + cellular macromolecule formation + cellular macromolecule synthesis + biological_process + GO:0034645 + cellular macromolecule biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. + GOC:mah + + + + + cellular biopolymer biosynthetic process + GOC:mtg_chebi_dec09 + + + + + cellular macromolecule anabolism + GOC:mah + + + + + cellular macromolecule biosynthesis + GOC:mah + + + + + cellular macromolecule formation + GOC:mah + + + + + cellular macromolecule synthesis + GOC:mah + + + + @@ -14990,7 +14840,6 @@ For example, A and B may be gene products and binding of B by A positively regul The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GO:0034960 GO:0043283 GO:0044259 biopolymer metabolic process @@ -15248,7 +15097,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + @@ -15257,11 +15106,10 @@ For example, A and B may be gene products and binding of B by A positively regul The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. amide metabolism - cellular amide metabolic process biological_process GO:0043603 - amide metabolic process + cellular amide metabolic process @@ -15460,7 +15308,6 @@ For example, A and B may be gene products and binding of B by A positively regul intermediary metabolism GO:0044237 - This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. cellular metabolic process @@ -15522,6 +15369,34 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. + GO:0034960 + cellular biopolymer metabolic process + cellular macromolecule metabolism + biological_process + GO:0044260 + cellular macromolecule metabolic process + + + + + The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. + GOC:mah + + + + + cellular biopolymer metabolic process + GOC:mtg_chebi_dec09 + + + + @@ -15807,7 +15682,7 @@ For example, A and B may be gene products and binding of B by A positively regul - The controlled breakdown of the nuclear membranes, for example during cellular division. + The controlled breakdown of the nuclear membranes, for example during cellular division. biological_process nuclear envelope breakdown nuclear envelope catabolism @@ -15819,7 +15694,7 @@ For example, A and B may be gene products and binding of B by A positively regul - The controlled breakdown of the nuclear membranes, for example during cellular division. + The controlled breakdown of the nuclear membranes, for example during cellular division. GOC:ai @@ -16271,16 +16146,14 @@ For example, A and B may be gene products and binding of B by A positively regul Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. - https://github.com/geneontology/go-ontology/issues/25143 mah 2010-09-08T10:10:35Z RNA-protein complex subunit organization protein-RNA complex subunit organization ribonucleoprotein complex subunit organisation - ribonucleoprotein complex subunit organization biological_process GO:0071826 - protein-RNA complex organization + ribonucleoprotein complex subunit organization @@ -16351,7 +16224,7 @@ For example, A and B may be gene products and binding of B by A positively regul - The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. + The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. mah 2010-10-04T01:51:47Z cellular_component @@ -16362,8 +16235,8 @@ For example, A and B may be gene products and binding of B by A positively regul - The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. - GOC:pdt + The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. + GOC:mah @@ -16683,7 +16556,6 @@ For example, A and B may be gene products and binding of B by A positively regul 2019-08-12T18:01:37Z cellular_component GO:0110165 - cellular anatomical entity @@ -17159,7 +17031,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + @@ -17168,7 +17040,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + The chemical reactions and pathways involving an alpha-amino acid. @@ -17203,7 +17075,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + @@ -17213,7 +17085,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + The chemical reactions and pathways resulting in the formation of an alpha-amino acid. @@ -17399,7 +17271,6 @@ For example, A and B may be gene products and binding of B by A positively regul A protein complex which is capable of catalytic activity. - https://github.com/geneontology/go-ontology/issues/19980 bhm 2013-11-13T16:18:47Z enzyme complex @@ -17710,7 +17581,7 @@ For example, A and B may be gene products and binding of B by A positively regul A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities - PATOC:GVG + PATOC:GVG @@ -17729,7 +17600,7 @@ For example, A and B may be gene products and binding of B by A positively regul A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure. - PATOC:GVG + PATOC:GVG @@ -17760,7 +17631,7 @@ For example, A and B may be gene products and binding of B by A positively regul A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average. - PATOC:GVG + PATOC:GVG @@ -17780,7 +17651,7 @@ For example, A and B may be gene products and binding of B by A positively regul A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude. - WordNet:WordNet + WordNet:WordNet @@ -17825,7 +17696,7 @@ For example, A and B may be gene products and binding of B by A positively regul A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average. - PATOC:GVG + PATOC:GVG @@ -17864,7 +17735,7 @@ For example, A and B may be gene products and binding of B by A positively regul A duration quality of a process which is relatively high. - PATOC:GVG + PATOC:GVG @@ -17902,7 +17773,7 @@ For example, A and B may be gene products and binding of B by A positively regul A size quality which is relatively high. - PATOC:GVG + PATOC:GVG @@ -17924,7 +17795,7 @@ For example, A and B may be gene products and binding of B by A positively regul A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities. - PATOC:GVG + PATOC:GVG @@ -17950,7 +17821,7 @@ For example, A and B may be gene products and binding of B by A positively regul A quality which inheres in an process. - PATOC:GVG + PATOC:GVG @@ -17980,7 +17851,7 @@ For example, A and B may be gene products and binding of B by A positively regul A quality which inheres in a continuant. - PATOC:GVG + PATOC:GVG @@ -18021,7 +17892,7 @@ For example, A and B may be gene products and binding of B by A positively regul A monadic quality of continuant that exists at the cellular level of organisation. - PATOC:GVG + PATOC:GVG @@ -18040,7 +17911,7 @@ For example, A and B may be gene products and binding of B by A positively regul A cellular quality inhering in a bearer by virtue of bearer's number of nuclei. - PATOC:GVG + PATOC:GVG @@ -18061,7 +17932,7 @@ For example, A and B may be gene products and binding of B by A positively regul A nucleate quality inhering in a bearer by virtue of the bearer's having no nucleus. - Biology-online:Biology-online + Biology-online:Biology-online @@ -18082,7 +17953,7 @@ For example, A and B may be gene products and binding of B by A positively regul A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei. - Biology-online:Biology-online + Biology-online:Biology-online @@ -18103,7 +17974,7 @@ For example, A and B may be gene products and binding of B by A positively regul A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus. - Biology-online:Biology-online + Biology-online:Biology-online @@ -18175,7 +18046,7 @@ For example, A and B may be gene products and binding of B by A positively regul A duration quality of a process inhering in a bearer by virtue of the bearer's having slow progressive course of indefinite duration. - PATOC:cjm + PATOC:cjm @@ -18195,7 +18066,7 @@ For example, A and B may be gene products and binding of B by A positively regul A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus. - PATOC:GVG + PATOC:GVG @@ -18232,7 +18103,7 @@ For example, A and B may be gene products and binding of B by A positively regul An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for basic dyes under specific pH conditions. - PATOC:GVG + PATOC:GVG @@ -18253,7 +18124,7 @@ For example, A and B may be gene products and binding of B by A positively regul A quality inhering in a bearer by virtue of its constitution. - PATOC:GVG + PATOC:GVG @@ -18291,7 +18162,7 @@ For example, A and B may be gene products and binding of B by A positively regul A quality that has a value that is increased compared to normal or average. - PATOC:GVG + PATOC:GVG @@ -18324,7 +18195,7 @@ For example, A and B may be gene products and binding of B by A positively regul A quality of a process that has a value that is increased compared to normal or average. - PATOC:GVG + PATOC:GVG @@ -18357,7 +18228,7 @@ For example, A and B may be gene products and binding of B by A positively regul A quality of an object that has a value that is increased compared to normal or average. - PATOC:GVG + PATOC:GVG @@ -18381,7 +18252,7 @@ For example, A and B may be gene products and binding of B by A positively regul An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for acidic dyes under specific pH conditions. - PATOC:GVG + PATOC:GVG @@ -18403,7 +18274,7 @@ For example, A and B may be gene products and binding of B by A positively regul A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus. - PATOC:GVG + PATOC:GVG @@ -18508,9 +18379,8 @@ For example, A and B may be gene products and binding of B by A positively regul - - 2 - + + An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds. @@ -18518,7 +18388,7 @@ For example, A and B may be gene products and binding of B by A positively regul polypeptide protein PR:000018263 - Category=polymer. + Category=external. amino acid chain @@ -18586,70 +18456,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - - - - - - - - - - - - - - - - - - A material entity that minimally consists of a protein. - protein - protein aggregate - protein complex - protein-containing complex - protein - PR:000050567 - Note: This includes single proteins and derivatives thereof (PR:000000001), protein-containing complexes (GO:0032991), and protein aggregates (PR:000050566). - protein-containing material entity - - - - - A material entity that minimally consists of a protein. - PRO:DAN - - - - - protein - PRO:DAN - - - - - protein aggregate - PRO:DAN - - - - - protein complex - PRO:DAN - - - - - protein-containing complex - PRO:DAN - - - - @@ -18659,14 +18465,9 @@ For example, A and B may be gene products and binding of B by A positively regul - An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity. - - - uberon UBERON:0000000 - processual entity @@ -18679,278 +18480,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - - - - - - - Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. - - - - AAO:0010825 - AEO:0000003 - BILA:0000003 - CARO:0000003 - EHDAA2:0003003 - EMAPA:0 - FBbt:00007001 - FMA:305751 - FMA:67135 - GAID:781 - HAO:0000003 - MA:0003000 - MESH:D000825 - SCTID:362889002 - TAO:0000037 - TGMA:0001823 - VHOG:0001759 - XAO:0003000 - ZFA:0000037 - http://dbpedia.org/ontology/AnatomicalStructure - biological structure - connected biological structure - uberon - UBERON:0000061 - - - anatomical structure - - - - - Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. - CARO:0000003 - - - - - connected biological structure - CARO:0000003 - - - - - - - - - - - - - - - - End of the life of an organism. - - - - ncit:Death is an outcome - XAO:0000437 - XtroDO:0000085 - uberon - death - UBERON:0000071 - - death stage - - - - - End of the life of an organism. - XAO:0000437 - - - - - ncit:Death is an outcome - ncit - - - - - - - - - - - - - - - - - - - - - - An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism. - - - - FBdv:00000000 - HsapDv:0000001 - MmusDv:0000001 - OGES:000011 - ncithesaurus:Life - entire life cycle - entire lifespan - life - lifespan - uberon - UBERON:0000104 - - - life cycle - https://github.com/obophenotype/uberon/issues/532 - - - - - An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism. - https://orcid.org/0000-0002-6601-2165 - - - - - - - - - - - - - - - A spatiotemporal region encompassing some part of the life cycle of an organism. - this class represents a proper part of the life cycle of an organism. The class 'life cycle' should not be placed here - - - - the WBls class 'all stages' belongs here as it is the superclass of other WBls stages - we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage - BILS:0000105 - EFO:0000399 - FBdv:00007012 - FMA:24120 - HsapDv:0000000 - MESH:D008018 - MmusDv:0000000 - OlatDv:0000010 - PdumDv:0000090 - WBls:0000002 - XAO:1000000 - ZFS:0000000 - ZFS:0100000 - ncithesaurus:Developmental_Stage - developmental stage - stage - uberon - UBERON:0000105 - - - - life cycle stage - - - - - A spatiotemporal region encompassing some part of the life cycle of an organism. - https://orcid.org/0000-0002-6601-2165 - - - - - - - - - - Anatomical entity that has mass. - - - - AAO:0010264 - AEO:0000006 - BILA:0000006 - CARO:0000006 - EHDAA2:0003006 - FBbt:00007016 - FMA:67165 - HAO:0000006 - TAO:0001836 - TGMA:0001826 - VHOG:0001721 - uberon - UBERON:0000465 - - - material anatomical entity - - - - - Anatomical entity that has mass. - http://orcid.org/0000-0001-9114-8737 - - - - - - - - Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. - - - - AAO:0010841 - AEO:0000000 - BILA:0000000 - BIRNLEX:6 - CARO:0000000 - EHDAA2:0002229 - FBbt:10000000 - FMA:62955 - HAO:0000000 - MA:0000001 - NCIT:C12219 - TAO:0100000 - TGMA:0001822 - UMLS:C1515976 - WBbt:0000100 - XAO:0000000 - ZFA:0100000 - uberon - UBERON:0001062 - - - anatomical entity - - - - - Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. - FMA:62955 - http://orcid.org/0000-0001-9114-8737 - - - - - UMLS:C1515976 - ncithesaurus:Anatomic_Structure_System_or_Substance - - - - - - - - inheres in - this fragility inheres in this vase - this red color inheres in this apple - a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence - A dependent inheres in its bearer at all times for which the dependent exists. - inheres_in - - inheres in - - - - - - - - - bearer of - this apple is bearer of this red color - this vase is bearer of this fragility - a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence - A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist. - bearer_of - is bearer of - - bearer of - - - - @@ -682,35 +649,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - - - this red color is a quality of this apple - a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence - A quality inheres in its bearer at all times for which the quality exists. - is quality of - quality_of - quality of - - - - - - - - - - this apple has quality this red color - a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence - A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist. - has_quality - has quality - - - - @@ -2082,7 +2020,6 @@ A and B can be physically interacting but not necessarily. Immediately upstream - realizable RealizableEntity the disposition of this piece of metal to conduct electricity. @@ -2126,15 +2063,6 @@ A and B can be physically interacting but not necessarily. Immediately upstream - - - - - quality - - - - diff --git a/src/ontology/imports/ro_import.owl b/src/ontology/imports/ro_import.owl index 139ad77..466a33e 100644 --- a/src/ontology/imports/ro_import.owl +++ b/src/ontology/imports/ro_import.owl @@ -7,7 +7,6 @@ xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:xml="http://www.w3.org/XML/1998/namespace" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" - xmlns:core="http://purl.obolibrary.org/obo/uberon/core#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:swrl="http://www.w3.org/2003/11/swrl#" @@ -17,9 +16,9 @@ xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - - 2023-12-18 + + + 2022-10-05 @@ -38,11 +37,6 @@ - editor preferred term - - The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English) - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obolibrary.org/obo/obi> editor preferred term @@ -51,12 +45,7 @@ - example of usage - A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obolibrary.org/obo/obi> - example of usage example of usage @@ -71,33 +60,8 @@ - definition - The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. - 2012-04-05: -Barry Smith - -The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. - -Can you fix to something like: - -A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. - -Alan Ruttenberg - -Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. - -On the specifics of the proposed definition: - -We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. - -Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. - -We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition - definition @@ -111,12 +75,7 @@ We also have the outstanding issue of how to aim different definitions to differ - term editor - Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people - 20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obolibrary.org/obo/obi> term editor @@ -125,14 +84,8 @@ We also have the outstanding issue of how to aim different definitions to differ - alternative label - A label for a class or property that can be used to refer to the class or property instead of the preferred rdfs:label. Alternative labels should be used to indicate community- or context-specific labels, abbreviations, shorthand forms and the like. - OBO Operations committee - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obolibrary.org/obo/obi> - Consider re-defing to: An alternative name for a class or property which can mean the same thing as the preferred name (semantically equivalent, narrow, broad or related). - alternative label + alternative term @@ -140,12 +93,7 @@ We also have the outstanding issue of how to aim different definitions to differ - definition source - Formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007 - PERSON:Daniel Schober - Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w - GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition source @@ -157,9 +105,9 @@ We also have the outstanding issue of how to aim different definitions to differ - + - + @@ -187,12 +135,6 @@ We also have the outstanding issue of how to aim different definitions to differ - - - - - - @@ -207,12 +149,6 @@ We also have the outstanding issue of how to aim different definitions to differ - - - - - - @@ -289,22 +225,6 @@ We also have the outstanding issue of how to aim different definitions to differ - - - - - - - - - - - - - - - - @@ -323,6 +243,12 @@ We also have the outstanding issue of how to aim different definitions to differ + + + + + + @@ -380,12 +306,7 @@ We also have the outstanding issue of how to aim different definitions to differ - An alternative label for a class or property which has a more general meaning than the preferred name/primary label. - - https://github.com/information-artifact-ontology/ontology-metadata/issues/18 - has broad synonym has_broad_synonym - https://github.com/information-artifact-ontology/ontology-metadata/issues/18 @@ -401,12 +322,7 @@ We also have the outstanding issue of how to aim different definitions to differ - An alternative label for a class or property which has the exact same meaning than the preferred name/primary label. - - https://github.com/information-artifact-ontology/ontology-metadata/issues/20 - has exact synonym has_exact_synonym - https://github.com/information-artifact-ontology/ontology-metadata/issues/20 @@ -417,24 +333,12 @@ We also have the outstanding issue of how to aim different definitions to differ - - - - - - - - - - - - @@ -497,7 +401,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An http://www.obofoundry.org/ro/#OBO_REL:part_of - https://wiki.geneontology.org/Part_of @@ -544,7 +447,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. is preceded by preceded_by - http://www.obofoundry.org/ro/#OBO_REL:preceded_by + http://www.obofoundry.org/ro/#OBO_REL:preceded_by preceded by @@ -639,7 +542,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. a relation between a process and a continuant, in which the continuant is somehow involved in the process Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. has_participant - http://www.obofoundry.org/ro/#OBO_REL:has_participant + http://www.obofoundry.org/ro/#OBO_REL:has_participant has participant @@ -769,7 +672,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B. - + dos 2017-05-24T09:30:46Z has regulatory component activity @@ -782,7 +685,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B. - + dos 2017-05-24T09:31:01Z By convention GO molecular functions are classified by their effector function. Internal regulatory functions are treated as components. For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'. has negative regulatory component activity @@ -796,7 +699,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B. - + dos 2017-05-24T09:31:17Z By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'. has positive regulatory component activity @@ -808,7 +711,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. - + dos 2017-05-24T09:44:33Z A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B. has component activity @@ -823,7 +726,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. - + dos 2017-05-24T09:49:21Z has component process @@ -835,7 +738,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. - + dos 2017-09-17T13:52:24Z Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. directly regulated by @@ -844,7 +747,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. - + GOC:dos @@ -855,7 +758,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1. - + dos 2017-09-17T13:52:38Z directly negatively regulated by @@ -863,7 +766,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1. - + GOC:dos @@ -874,7 +777,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1. - + dos 2017-09-17T13:52:47Z directly positively regulated by @@ -882,7 +785,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1. - + GOC:dos @@ -893,7 +796,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity. - + dos 2017-09-22T14:14:36Z This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations. has effector activity @@ -902,7 +805,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity. - + GOC:dos @@ -937,7 +840,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - David Osumi-Sutherland ends_at_start_of meets @@ -1017,10 +919,10 @@ A continuant cannot have an occurrent as part: use 'participates in'. x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y - - - - + Chris Mungall + David Osumi-Sutherland + Melissa Haendel + Terry Meehan This is the transitive form of the develops from relation develops from @@ -1036,9 +938,9 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of develops from - - - + Chris Mungall + David Osumi-Sutherland + Terry Meehan develops into @@ -1061,10 +963,12 @@ A continuant cannot have an occurrent as part: use 'participates in'. - p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q. - - - + + process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2. + We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit + Chris Mungall + David Hill + Tanya Berardini GO Regulation precludes parthood; the regulatory process may not be within the regulated process. @@ -1084,8 +988,8 @@ A continuant cannot have an occurrent as part: use 'participates in'. - p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q. - + Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2. + Chris Mungall negatively regulates (process to process) @@ -1108,8 +1012,8 @@ A continuant cannot have an occurrent as part: use 'participates in'. - p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q. - + Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2. + Chris Mungall positively regulates (process to process) @@ -1130,7 +1034,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974) osteoclast SubClassOf 'capable of' some 'bone resorption' A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. - + Chris Mungall has function realized in @@ -1151,7 +1055,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. - + Chris Mungall has function in capable of part of @@ -1174,7 +1078,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. - + Chris Mungall Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends. https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1 @@ -1193,14 +1097,13 @@ A continuant cannot have an occurrent as part: use 'participates in'. p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p. - + Chris Mungall consumes has input - https://wiki.geneontology.org/Has_input @@ -1212,14 +1115,13 @@ A continuant cannot have an occurrent as part: use 'participates in'. p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p. - + Chris Mungall produces has output - https://wiki.geneontology.org/Has_output @@ -1229,8 +1131,8 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - + + @@ -1238,7 +1140,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. Mammalian thymus has developmental contribution from some pharyngeal pouch 3; Mammalian thymus has developmental contribution from some pharyngeal pouch 4 [Kardong] x has developmental contribution from y iff x has some part z such that z develops from y - + Chris Mungall has developmental contribution from @@ -1255,7 +1157,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of has developmental contribution from - + Chris Mungall developmentally contributes to @@ -1272,7 +1174,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p false - + Chris Mungall In general you should not use this relation to make assertions - use one of the more specific relations below this one This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from developmentally preceded by @@ -1310,7 +1212,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. affects acts upstream of or within - https://wiki.geneontology.org/Acts_upstream_of_or_within + @@ -1321,7 +1223,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. Inverse of developmentally preceded by - + Chris Mungall developmentally succeeded by @@ -1332,14 +1234,12 @@ A continuant cannot have an occurrent as part: use 'participates in'. - p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q. - + cjm holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y causally upstream of, positive effect - @@ -1349,13 +1249,10 @@ A continuant cannot have an occurrent as part: use 'participates in'. - p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q. - - - + cjm + holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y causally upstream of, negative effect - @@ -1374,7 +1271,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w. Because part_of is transitive, inheres in is a sub-relation of characteristic of part of - + Chris Mungall inheres in part of @@ -1397,7 +1294,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. A mereological relationship or a topological relationship - + Chris Mungall Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships mereotopologically related to @@ -1409,7 +1306,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. A relationship that holds between entities participating in some developmental process (GO:0032502) - + Chris Mungall Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving organismal development developmentally related to @@ -1430,8 +1327,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. a particular instances of akt-2 enables some instance of protein kinase activity - c enables p iff c is capable of p and c acts to execute p. - + Chris Mungall catalyzes executes has @@ -1440,7 +1336,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized. enables - https://wiki.geneontology.org/Enables @@ -1449,7 +1344,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities. - + Chris Mungall This is a grouping relation that collects relations used for the purpose of connecting structure and function functionally related to @@ -1465,7 +1360,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. this relation holds between c and p when c is part of some c', and c' is capable of p. - + Chris Mungall false part of structure that is capable of @@ -1495,11 +1390,11 @@ A continuant cannot have an occurrent as part: use 'participates in'. c involved_in p if and only if c enables some process p', and p' is part of p - + Chris Mungall actively involved in enables part of involved in - https://wiki.geneontology.org/Involved_in + @@ -1510,10 +1405,9 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of enables - + Chris Mungall enabled by - https://wiki.geneontology.org/Enabled_by @@ -1526,7 +1420,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of regulates - + Chris Mungall regulated by (processual) regulated by @@ -1539,7 +1433,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of negatively regulates - + Chris Mungall negatively regulated by @@ -1551,7 +1445,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of positively regulates - + Chris Mungall positively regulated by @@ -1564,7 +1458,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of has input - + Chris Mungall input of @@ -1578,7 +1472,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of has output - + Chris Mungall output of @@ -1590,11 +1484,11 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - + + x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction). - + Chris Mungall has developmental potential involving @@ -1606,7 +1500,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y - + Chris Mungall has potential to developmentally contribute to @@ -1618,7 +1512,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. x has the potential to develop into y iff x develops into y or if x is capable of developing into y - + Chris Mungall has potential to develop into @@ -1630,7 +1524,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y - + Chris Mungall has potential to directly develop into @@ -1644,7 +1538,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of upstream of - + Chris Mungall causally downstream of @@ -1657,83 +1551,24 @@ A continuant cannot have an occurrent as part: use 'participates in'. - + Chris Mungall immediately causally downstream of - - - - - - - - - - - - - - - - - - - - - - - p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q. - - indirectly activates - - indirectly positively regulates - https://wiki.geneontology.org/Indirectly_positively_regulates - - - - - - - - - - - - - - - - - - - - - - - p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q. - - indirectly inhibits - - indirectly negatively regulates - https://wiki.geneontology.org/Indirectly_negatively_regulates - - - - - relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause. + + This relation groups causal relations between material entities and causal relations between processes This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents. To define causal relations in an activity-flow type network, we make use of 3 primitives: * Temporal: how do the intervals of the two occurrents relate? * Is the causal relation regulatory? - * Is the influence positive or negative? + * Is the influence positive or negative The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified. @@ -1742,16 +1577,10 @@ For the second, we consider a relationship to be regulatory if the system in whi For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral. Each of these 3 primitives can be composed to yield a cross-product of different relation types. - + Chris Mungall Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. causally related to - - - - relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause. - https://en.wikipedia.org/wiki/Causality - @@ -1761,8 +1590,9 @@ Each of these 3 primitives can be composed to yield a cross-product of different - p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q. - + + p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain + Chris Mungall causally upstream of @@ -1775,8 +1605,9 @@ Each of these 3 primitives can be composed to yield a cross-product of different - p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q. - + + p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q. + Chris Mungall immediately causally upstream of @@ -1789,9 +1620,9 @@ Each of these 3 primitives can be composed to yield a cross-product of different - p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q. + p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q. We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2 - + Chris Mungall influences (processual) affects causally upstream of or within @@ -1805,7 +1636,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different inverse of causally upstream of or within - + Chris Mungall causally downstream of or within @@ -1827,7 +1658,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different c involved in regulation of p if c is involved in some p' and p' regulates some p - + Chris Mungall involved in regulation of @@ -1846,7 +1677,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different c involved in regulation of p if c is involved in some p' and p' positively regulates some p - + Chris Mungall involved in positive regulation of @@ -1866,7 +1697,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different c involved in regulation of p if c is involved in some p' and p' negatively regulates some p - + Chris Mungall involved in negative regulation of @@ -1881,7 +1712,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p OWL does not allow defining object properties via a Union - + Chris Mungall involved in or reguates involved in or involved in regulation of @@ -1897,7 +1728,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different A relationship that holds between two entities in which the processes executed by the two entities are causally connected. Considering relabeling as 'pairwise interacts with' This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact. - + Chris Mungall Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules. in pairwise interaction with @@ -1914,7 +1745,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other. - + Chris Mungall binds molecularly binds with molecularly interacts with @@ -1929,7 +1760,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different Axiomatization to GO to be added later - + Chris Mungall An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y. phosphorylates @@ -1951,8 +1782,8 @@ Each of these 3 primitives can be composed to yield a cross-product of different The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B. - - + Chris Mungall + Vasundra Touré molecularly controls directly regulates activity of @@ -1972,8 +1803,8 @@ A and B can be physically interacting but not necessarily. Immediately upstream The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B. - - + Chris Mungall + Vasundra Touré directly inhibits molecularly decreases activity of directly negatively regulates activity of @@ -1994,8 +1825,8 @@ For example, A and B may be gene products and binding of B by A negatively regul The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B. - - + Chris Mungall + Vasundra Touré directly activates molecularly increases activity of directly positively regulates activity of @@ -2006,7 +1837,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + Chris Mungall This property or its subproperties is not to be used directly. These properties exist as helper properties that are used to support OWL reasoning. helper property (not for use in curation) @@ -2017,7 +1848,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + Chris Mungall is kinase activity @@ -2028,7 +1859,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + Chris Mungall Do not use this relation directly. It is ended as a grouping for a diverse set of relations, typically connecting an anatomical entity to a biological process or developmental stage. relation between physical entity and a process or stage @@ -2040,7 +1871,7 @@ For example, A and B may be gene products and binding of B by A positively regul x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y)) - + Chris Mungall The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. existence overlaps @@ -2057,7 +1888,7 @@ For example, A and B may be gene products and binding of B by A positively regul x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y). - + Chris Mungall The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. existence ends during @@ -2069,7 +1900,7 @@ For example, A and B may be gene products and binding of B by A positively regul x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y). - + Chris Mungall The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. existence ends with @@ -2097,7 +1928,7 @@ For example, A and B may be gene products and binding of B by A positively regul x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends. - + Chris Mungall The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. existence ends during or before @@ -2122,8 +1953,8 @@ For example, A and B may be gene products and binding of B by A positively regul - p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q. - + p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q. + Chris Mungall Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. causal relation between processes @@ -2134,7 +1965,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + Chris Mungall depends on @@ -2148,7 +1979,7 @@ For example, A and B may be gene products and binding of B by A positively regul The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch - + Chris Mungall Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. causal relation between entities @@ -2161,7 +1992,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + Chris Mungall causally influenced by (entity-centric) causally influenced by @@ -2173,7 +2004,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + Chris Mungall interaction relation helper property http://purl.obolibrary.org/obo/ro/docs/interaction-relations/ @@ -2185,7 +2016,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + Chris Mungall molecular interaction relation helper property @@ -2208,8 +2039,8 @@ For example, A and B may be gene products and binding of B by A positively regul The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size). - - + Chris Mungall + Vasundra Touré causally influences (entity-centric) causally influences @@ -2222,8 +2053,8 @@ For example, A and B may be gene products and binding of B by A positively regul - p directly regulates q iff p is immediately causally upstream of q and p regulates q. - + Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. + Chris Mungall directly regulates (processual) @@ -2246,7 +2077,7 @@ For example, A and B may be gene products and binding of B by A positively regul gland SubClassOf 'has part structure that is capable of' some 'secretion by cell' s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p - + Chris Mungall has part structure that is capable of @@ -2260,7 +2091,7 @@ For example, A and B may be gene products and binding of B by A positively regul A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity. Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. - + Chris Mungall causal relation between material entity and a process @@ -2330,7 +2161,7 @@ For example, A and B may be gene products and binding of B by A positively regul - p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q. + Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2. directly positively regulates (process to process) @@ -2338,7 +2169,6 @@ For example, A and B may be gene products and binding of B by A positively regul directly positively regulates - https://wiki.geneontology.org/Directly_positively_regulates @@ -2348,7 +2178,7 @@ For example, A and B may be gene products and binding of B by A positively regul - p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q. + Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2. directly negatively regulates (process to process) @@ -2356,7 +2186,6 @@ For example, A and B may be gene products and binding of B by A positively regul directly negatively regulates - https://wiki.geneontology.org/Directly_negatively_regulates @@ -2372,7 +2201,7 @@ For example, A and B may be gene products and binding of B by A positively regul A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M. - + cjm 2017-12-26T19:45:49Z realized in response to stimulus @@ -2388,7 +2217,7 @@ For example, A and B may be gene products and binding of B by A positively regul Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P. - + cjm 2018-01-25T23:20:13Z enables subfunction @@ -2404,11 +2233,11 @@ For example, A and B may be gene products and binding of B by A positively regul - + cjm 2018-01-26T23:49:30Z acts upstream of or within, positive effect - https://wiki.geneontology.org/Acts_upstream_of_or_within,_positive_effect + @@ -2422,11 +2251,10 @@ For example, A and B may be gene products and binding of B by A positively regul - + cjm 2018-01-26T23:49:51Z acts upstream of or within, negative effect - https://wiki.geneontology.org/Acts_upstream_of_or_within,_negative_effect @@ -2442,11 +2270,11 @@ For example, A and B may be gene products and binding of B by A positively regul c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive - + cjm 2018-01-26T23:53:14Z acts upstream of, positive effect - https://wiki.geneontology.org/Acts_upstream_of,_positive_effect + @@ -2462,11 +2290,11 @@ For example, A and B may be gene products and binding of B by A positively regul c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative - + cjm 2018-01-26T23:53:22Z acts upstream of, negative effect - https://wiki.geneontology.org/Acts_upstream_of,_negative_effect + @@ -2476,10 +2304,9 @@ For example, A and B may be gene products and binding of B by A positively regul - + cjm 2018-03-13T23:55:05Z causally upstream of or within, negative effect - https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect @@ -2489,10 +2316,9 @@ For example, A and B may be gene products and binding of B by A positively regul - + cjm 2018-03-13T23:55:19Z causally upstream of or within, positive effect - @@ -2507,10 +2333,10 @@ For example, A and B may be gene products and binding of B by A positively regul An inflammatory disease that is realized in response to an inflammatory process occurring in the gut (which is itself the realization of a process realized in response to harmful stimuli in the mucosal lining of th gut) Environmental polymorphism in butterflies: These butterflies have a 'responsivity to day length trait' that is realized in response to the duration of the day, and is realized in developmental processes that lead to increased or decreased pigmentation in the adult morph. r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r. - - - - + Austin Meier + Chris Mungall + David Osumi-Sutherland + Marie Angelique Laporte triggered by process realized in response to https://docs.google.com/document/d/1KWhZxVBhIPkV6_daHta0h6UyHbjY2eIrnON1WIRGgdY/edit @@ -2519,7 +2345,7 @@ For example, A and B may be gene products and binding of B by A positively regul triggered by process - + RO:cjm @@ -2531,37 +2357,12 @@ For example, A and B may be gene products and binding of B by A positively regul The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B. - + Vasundra Touré regulates activity of - - - - - p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q. - - 2022-09-26T06:07:17Z - indirectly causally upstream of - - - - - - - - - - p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q. - - 2022-09-26T06:08:01Z - indirectly regulates - - - - @@ -2571,11 +2372,11 @@ For example, A and B may be gene products and binding of B by A positively regul A diagnostic testing device utilizes a specimen. X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y. - - + https://orcid.org/0000-0001-9625-1899 + https://orcid.org/0000-0003-2620-0345 A diagnostic testing device utilizes a specimen means that the diagnostic testing device is capable of an assay, and this assay a specimen as its input. See github ticket https://github.com/oborel/obo-relations/issues/497 - 2021-11-08T12:00:00Z + 2021-11-08T12:00:00Z utilizes device utilizes material @@ -2698,9 +2499,7 @@ For example, A and B may be gene products and binding of B by A positively regul - - b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) - A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. + A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. independent continuant @@ -2710,8 +2509,7 @@ For example, A and B may be gene products and binding of B by A positively regul - p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) - An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. + An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. process @@ -2769,9 +2567,7 @@ For example, A and B may be gene products and binding of B by A positively regul - - b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) - A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. + A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. specifically dependent continuant @@ -2787,23 +2583,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - - - - - - - b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) - A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time. - generically dependent continuant - - - - @@ -2823,6 +2602,46 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + anatomical entity + + + + + + + + + + connected anatomical structure + + + + + + + + + + + material anatomical entity + + + + + + + + + biological entity + + + + @@ -2834,26 +2653,10 @@ For example, A and B may be gene products and binding of B by A positively regul - - A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. - CALOHA:TS-2035 - FBbt:00007002 - FMA:68646 - GO:0005623 - KUPO:0000002 - MESH:D002477 - VHOG:0001533 - WBbt:0004017 - XAO:0003012 - The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). - cell + + + cell - - - - A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. - CARO:mah - @@ -2861,139 +2664,68 @@ For example, A and B may be gene products and binding of B by A positively regul - A system which has the disposition to environ one or more material entities. - 2013-09-23T16:04:08Z - EcoLexicon:environment - environment - In ENVO's alignment with the Basic Formal Ontology, this class is being considered as a subclass of a proposed BFO class "system". The relation "environed_by" is also under development. Roughly, a system which includes a material entity (at least partially) within its site and causally influences that entity may be considered to environ it. Following the completion of this alignment, this class' definition and the definitions of its subclasses will be revised. environmental system - - - - A system which has the disposition to environ one or more material entities. - DOI:10.1186/2041-1480-4-43 - - A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. - molecular function - GO:0003674 - Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. + + molecular process molecular_function - - - - A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. - GOC:pdt - + + + + + + + + catalytic activity + - A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. - jl - 2012-09-19T15:05:24Z - Wikipedia:Biological_process - biological process - physiological process - single organism process - single-organism process - GO:0008150 - Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. + biological_process - - - - A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. - GOC:pdt - - + true - Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. - Reactome:R-HSA-6788855 - Reactome:R-HSA-6788867 - phosphokinase activity - GO:0016301 - Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. kinase activity - - - - Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. - ISBN:0198506732 - - - - - Reactome:R-HSA-6788855 - FN3KRP phosphorylates PsiAm, RibAm - - - - - Reactome:R-HSA-6788867 - FN3K phosphorylates ketosamines - - + - - - information content entity - information content entity + + + transferase activity - + - - - - - - - - - - - - - - - - - curation status specification - - The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value. - Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting) - PERSON:Bill Bug - GROUP:OBI:<http://purl.obolibrary.org/obo/obi> - OBI_0000266 - curation status specification + + + transferase activity, transferring phosphorus-containing groups @@ -3002,16 +2734,9 @@ For example, A and B may be gene products and binding of B by A positively regul - A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities - PATO:0000001 + quality (PATO) quality - - - - A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities - PATOC:GVG - @@ -3021,249 +2746,13 @@ For example, A and B may be gene products and binding of B by A positively regul A material entity consisting of multiple components that are causally integrated. May be replaced by a BFO class, as discussed in http://www.jbiomedsem.com/content/4/1/43 - + Chris Mungall http://www.jbiomedsem.com/content/4/1/43 system - - - - - Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. - - - AAO:0010825 - AEO:0000003 - BILA:0000003 - CARO:0000003 - EHDAA2:0003003 - EMAPA:0 - FBbt:00007001 - FMA:305751 - FMA:67135 - GAID:781 - HAO:0000003 - MA:0003000 - MESH:D000825 - SCTID:362889002 - TAO:0000037 - TGMA:0001823 - VHOG:0001759 - XAO:0003000 - ZFA:0000037 - http://dbpedia.org/ontology/AnatomicalStructure - biological structure - connected biological structure - UBERON:0000061 - - - anatomical structure - - - - - Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. - CARO:0000003 - - - - - connected biological structure - CARO:0000003 - - - - - - - - - - Anatomical entity that has mass. - - - AAO:0010264 - AEO:0000006 - BILA:0000006 - CARO:0000006 - EHDAA2:0003006 - FBbt:00007016 - FMA:67165 - HAO:0000006 - TAO:0001836 - TGMA:0001826 - VHOG:0001721 - UBERON:0000465 - - - material anatomical entity - - - - - Anatomical entity that has mass. - http://orcid.org/0000-0001-9114-8737 - - - - - - - - - Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. - - - AAO:0010841 - AEO:0000000 - BILA:0000000 - BIRNLEX:6 - CARO:0000000 - EHDAA2:0002229 - FBbt:10000000 - FMA:62955 - HAO:0000000 - MA:0000001 - NCIT:C12219 - TAO:0100000 - TGMA:0001822 - UMLS:C1515976 - WBbt:0000100 - XAO:0000000 - ZFA:0100000 - UBERON:0001062 - - - anatomical entity - - - - - Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. - FMA:62955 - http://orcid.org/0000-0001-9114-8737 - - - - - UMLS:C1515976 - ncithesaurus:Anatomic_Structure_System_or_Substance - - - - - - - - - - - - - example to be eventually removed - example to be eventually removed - - - - - - - - metadata complete - Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete. - metadata complete - - - - - - - - organizational term - Term created to ease viewing/sort terms for development purpose, and will not be included in a release - organizational term - - - - - - - - ready for release - - Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release." - ready for release - - - - - - - - metadata incomplete - Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors. - metadata incomplete - - - - - - - - uncurated - Nothing done yet beyond assigning a unique class ID and proposing a preferred term. - uncurated - - - - - - - - - pending final vetting - - All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor. - pending final vetting - - - - - - - - to be replaced with external ontology term - Terms with this status should eventually replaced with a term from another ontology. - Alan Ruttenberg - group:OBI - to be replaced with external ontology term - - - - - - - - - requires discussion - - A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues. - Alan Ruttenberg - group:OBI - requires discussion - - - - - example of usage - - A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obolibrary.org/obo/obi> IAO:0000112 uberon example_of_usage @@ -95,31 +84,7 @@ - definition - The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. - 2012-04-05: -Barry Smith - -The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. - -Can you fix to something like: - -A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. - -Alan Ruttenberg - -Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. - -On the specifics of the proposed definition: - -We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. - -Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. - -We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition definition @@ -130,11 +95,6 @@ We also have the outstanding issue of how to aim different definitions to differ - editor note - - An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obofoundry.org/obo/obi> IAO:0000116 uberon editor_note @@ -177,9 +137,9 @@ We also have the outstanding issue of how to aim different definitions to differ - + - + @@ -213,15 +173,15 @@ We also have the outstanding issue of how to aim different definitions to differ - + - + - + - + @@ -275,12 +235,6 @@ We also have the outstanding issue of how to aim different definitions to differ - - - - - - @@ -299,18 +253,6 @@ We also have the outstanding issue of how to aim different definitions to differ - - - - - - - - - - - - @@ -465,14 +407,6 @@ We also have the outstanding issue of how to aim different definitions to differ - - - - - - - - @@ -523,33 +457,9 @@ We also have the outstanding issue of how to aim different definitions to differ - - - - - - - - - - - - - - - - - - - - - - - - - + - + @@ -579,6 +489,14 @@ We also have the outstanding issue of how to aim different definitions to differ + + + + + + + + @@ -659,14 +577,6 @@ We also have the outstanding issue of how to aim different definitions to differ - - - - - - - - @@ -689,14 +599,6 @@ We also have the outstanding issue of how to aim different definitions to differ - - - - - - - - @@ -705,54 +607,6 @@ We also have the outstanding issue of how to aim different definitions to differ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - @@ -761,10 +615,10 @@ We also have the outstanding issue of how to aim different definitions to differ - + - - + + abbreviation @@ -946,7 +800,7 @@ We also have the outstanding issue of how to aim different definitions to differ - http://purl.org/dc/elements/1.1/creator + uberon dc-creator true @@ -965,7 +819,7 @@ We also have the outstanding issue of how to aim different definitions to differ - http://purl.org/dc/elements/1.1/description + uberon dc-description true @@ -975,10 +829,16 @@ We also have the outstanding issue of how to aim different definitions to differ + + + + + + - http://purl.org/dc/elements/1.1/title + uberon dc-title true @@ -1009,7 +869,7 @@ We also have the outstanding issue of how to aim different definitions to differ - http://purl.org/dc/terms/license + uberon dcterms-license true @@ -1025,12 +885,6 @@ We also have the outstanding issue of how to aim different definitions to differ - - - - - - @@ -1063,17 +917,13 @@ We also have the outstanding issue of how to aim different definitions to differ - - created by - + - - creation date - + @@ -1146,12 +996,7 @@ We also have the outstanding issue of how to aim different definitions to differ - An alternative label for a class or property which has a more general meaning than the preferred name/primary label. - - https://github.com/information-artifact-ontology/ontology-metadata/issues/18 - has broad synonym has_broad_synonym - https://github.com/information-artifact-ontology/ontology-metadata/issues/18 @@ -1167,12 +1012,7 @@ We also have the outstanding issue of how to aim different definitions to differ - An alternative label for a class or property which has the exact same meaning than the preferred name/primary label. - - https://github.com/information-artifact-ontology/ontology-metadata/issues/20 - has exact synonym has_exact_synonym - https://github.com/information-artifact-ontology/ontology-metadata/issues/20 @@ -1231,6 +1071,12 @@ We also have the outstanding issue of how to aim different definitions to differ + + + + + + @@ -1243,6 +1089,12 @@ We also have the outstanding issue of how to aim different definitions to differ + + + + + + @@ -1279,6 +1131,12 @@ We also have the outstanding issue of how to aim different definitions to differ + + + + + + @@ -1333,18 +1191,6 @@ We also have the outstanding issue of how to aim different definitions to differ - - - - - - - - - - - - @@ -1357,35 +1203,15 @@ We also have the outstanding issue of how to aim different definitions to differ - - - - http://www.w3.org/2000/01/rdf-schema#seeAlso - spatial - uberon - seeAlso - true - seeAlso - see also - - - - - + - + - + - - - - - - - + @@ -1406,16 +1232,27 @@ We also have the outstanding issue of how to aim different definitions to differ + is part of is part of + my brain is part of my body (continuant parthood, two material entities) my brain is part of my body (continuant parthood, two material entities) + my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity) my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity) + this day is part of this year (occurrent parthood) this day is part of this year (occurrent parthood) + a core relation that holds between a part and its whole a core relation that holds between a part and its whole + Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. - Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ + Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ + Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime + Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) + +A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'. Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'. + part_of part_of @@ -1426,6 +1263,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BFO:0000050 + external + protein quality spatial uberon @@ -1441,7 +1280,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An http://www.obofoundry.org/ro/#OBO_REL:part_of - https://wiki.geneontology.org/Part_of @@ -1451,19 +1289,34 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + has part has part + my body has part my brain (continuant parthood, two material entities) my body has part my brain (continuant parthood, two material entities) + my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity) my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity) + this year has part this day (occurrent parthood) this year has part this day (occurrent parthood) + Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2. + a core relation that holds between a whole and its part a core relation that holds between a whole and its part + Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part. Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part. - Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ + Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ + Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime + Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) + +A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'. Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'. + has_part has_part BFO:0000051 + chebi_ontology + external + protein quality spatial uberon @@ -1471,11 +1324,19 @@ A continuant cannot have an occurrent as part: use 'participates in'. + false has_part + We use the has_part relation to relate complex qualities to more primitive ones. A complex quality is a collection of qualities. The complex quality cannot exist without the sub-qualities. For example, the quality 'swollen' necessarily comes with the qualities of 'protruding' and 'increased size'. has part has part has_part + + + + Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2. + PATOC:CJM + @@ -1492,19 +1353,35 @@ A continuant cannot have an occurrent as part: use 'participates in'. preceded by + X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X) x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. is preceded by preceded_by - http://www.obofoundry.org/ro/#OBO_REL:preceded_by + http://www.obofoundry.org/ro/#OBO_REL:preceded_by BFO:0000062 + is preceded by + takes place after uberon preceded_by preceded_by preceded by preceded by + preceded_by + + + + is preceded by + SIO:000249 + + + + + takes place after + Allen:precedes + @@ -1551,15 +1428,12 @@ A continuant cannot have an occurrent as part: use 'participates in'. occurs_in unfolds in unfolds_in - BFO:0000066 - occurs_in Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant occurs in - https://wiki.geneontology.org/Occurs_in @@ -1587,6 +1461,9 @@ A continuant cannot have an occurrent as part: use 'participates in'. x anterior to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail. + x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer + cjm + 2009-07-31T02:15:46Z BSPO:0000096 rostral_to spatial @@ -1594,6 +1471,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. anterior_to anterior_to anterior to + anterior_to @@ -1603,6 +1481,12 @@ A continuant cannot have an occurrent as part: use 'participates in'. x anterior to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail. BSPO:cjm + + + + x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer + + @@ -1612,12 +1496,14 @@ A continuant cannot have an occurrent as part: use 'participates in'. x dorsal to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that extends through an organism from back (e.g. spinal column) to front (e.g. belly). + x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). BSPO:0000098 spatial uberon dorsal_to dorsal_to dorsal to + dorsal_to @@ -1627,6 +1513,12 @@ A continuant cannot have an occurrent as part: use 'participates in'. x dorsal to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that extends through an organism from back (e.g. spinal column) to front (e.g. belly). BSPO:cjm + + + + x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). + + @@ -1635,13 +1527,16 @@ A continuant cannot have an occurrent as part: use 'participates in'. x posterior to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail. + x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail. BSPO:0000099 caudal to + caudal_to spatial uberon posterior_to posterior_to posterior to + posterior_to @@ -1651,6 +1546,12 @@ A continuant cannot have an occurrent as part: use 'participates in'. x posterior to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail. BSPO:cjm + + + + x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail. + + @@ -1665,12 +1566,14 @@ A continuant cannot have an occurrent as part: use 'participates in'. x ventral to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that extends through an organism from back (e.g. spinal column) to front (e.g. belly). + x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). BSPO:0000102 spatial uberon ventral_to ventral_to ventral to + ventral_to @@ -1680,6 +1583,12 @@ A continuant cannot have an occurrent as part: use 'participates in'. x ventral to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that extends through an organism from back (e.g. spinal column) to front (e.g. belly). BSPO:cjm + + + + x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). + + @@ -1695,7 +1604,14 @@ A continuant cannot have an occurrent as part: use 'participates in'. deep_to deep_to deep to + deep_to + + + + Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines. + + @@ -1716,7 +1632,14 @@ A continuant cannot have an occurrent as part: use 'participates in'. superficial_to superficial_to superficial to + superficial_to + + + + Near the outer surface of the organism. Thus, skin is superficial to the muscle layer. + + @@ -1733,7 +1656,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. X in left side of Y <=> if Y is subdivided into two left and right portions, X is part of the left portion. BSPO:0000120 - NCIT:C25229 spatial uberon in_left_side_of @@ -1756,7 +1678,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. X in right side of Y <=> if Y is subdivided into two left and right portions, X is part of the right portion. BSPO:0000121 - NCIT:C25228 spatial uberon in_right_side_of @@ -1778,12 +1699,14 @@ A continuant cannot have an occurrent as part: use 'participates in'. X posterior side of Y <=> if Y is subdivided into two anterior and posterior portions, X is part of the posterior portion. + X posterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the posterior portion. BSPO:0000122 spatial uberon in_posterior_side_of in_posterior_side_of in posterior side of + in_posterior_side_of @@ -1791,6 +1714,12 @@ A continuant cannot have an occurrent as part: use 'participates in'. X posterior side of Y <=> if Y is subdivided into two anterior and posterior portions, X is part of the posterior portion. BSPO:PATO_mtg_2009 + + + + X posterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the posterior portion. + BSPO:PATO_mtg_2009 + @@ -1799,12 +1728,14 @@ A continuant cannot have an occurrent as part: use 'participates in'. X anterior side of Y <=> if Y is subdivided into two anterior and posterior portions, X is part of the anterior portion. + X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion. BSPO:0000123 spatial uberon in_anterior_side_of in_anterior_side_of in anterior side of + in_anterior_side_of @@ -1812,6 +1743,12 @@ A continuant cannot have an occurrent as part: use 'participates in'. X anterior side of Y <=> if Y is subdivided into two anterior and posterior portions, X is part of the anterior portion. BSPO:PATO_mtg_2009 + + + + X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion. + BSPO:PATO_mtg_2009 + @@ -1819,6 +1756,8 @@ A continuant cannot have an occurrent as part: use 'participates in'. + + X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion. x in proximal side of y <=> if y is subdivided into two proximal and distal portions, y is part of the proximal portion. BSPO:0000124 spatial @@ -1826,7 +1765,14 @@ A continuant cannot have an occurrent as part: use 'participates in'. in_proximal_side_of in_proximal_side_of in proximal side of + in_proximal_side_of + + + + X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion. + BSPO:PATO_mtg_2009 + @@ -1840,6 +1786,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. + X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion. x in distal side of y <=> if y is subdivided into two proximal and distal portions, y is part of the distal portion. BSPO:0000125 spatial @@ -1847,7 +1794,14 @@ A continuant cannot have an occurrent as part: use 'participates in'. in_distal_side_of in_distal_side_of in distal side of + in_distal_side_of + + + + X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion. + BSPO:PATO_mtg_2009 + @@ -1862,12 +1816,14 @@ A continuant cannot have an occurrent as part: use 'participates in'. X in lateral side of Y <=> if X is in left side of Y or X is in right side of Y. X is often, but not always a paired structure + X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure BSPO:0000126 spatial uberon in_lateral_side_of in_lateral_side_of in lateral side of + in_lateral_side_of https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern @@ -1875,7 +1831,13 @@ A continuant cannot have an occurrent as part: use 'participates in'. X in lateral side of Y <=> if X is in left side of Y or X is in right side of Y. X is often, but not always a paired structure - UBERON:cjm + UBERON:cjm + + + + + X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure + @@ -1885,19 +1847,33 @@ A continuant cannot have an occurrent as part: use 'participates in'. X proximalmost part of Y <=> X is in proximal side of Y and X is adjacent to the proximal boundary of Y + X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y BSPO:0001106 spatial uberon proximalmost_part_of proximalmost_part_of proximalmost part of + proximalmost_part_of + + + + X proximalmost part of Y <=> X is in proximal side of Y and X is adjacent to the proximal boundary of Y + + X proximalmost part of Y <=> X is in proximal side of Y and X is adjacent to the proximal boundary of Y https://orcid.org/0000-0002-6601-2165 + + + + X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y + + @@ -1905,7 +1881,9 @@ A continuant cannot have an occurrent as part: use 'participates in'. + + This relation holds when both the deep_to and ajdacent_to relationship similarly hold. x immediately deep to y iff x deep_to y and x is contiguous with y. BSPO:0001107 spatial @@ -1913,7 +1891,14 @@ A continuant cannot have an occurrent as part: use 'participates in'. immediately_deep_to immediately_deep_to immediately deep to + immediately_deep_to + + + + This relation holds when both the deep_to and ajdacent_to relationship similarly hold. + + @@ -1928,19 +1913,33 @@ A continuant cannot have an occurrent as part: use 'participates in'. X distalmost part of Y <=> X is in distal side of Y and X is adjacent to the distal boundary of Y + X distalmost_part_of Y <=> X is part_of Y and X is adjacent_to the distal boundary of Y BSPO:0001108 spatial uberon distalmost_part_of distalmost_part_of distalmost part of + distalmost_part_of + + + + X distalmost part of Y <=> X is in distal side of Y and X is adjacent to the distal boundary of Y + + X distalmost part of Y <=> X is in distal side of Y and X is adjacent to the distal boundary of Y https://orcid.org/0000-0002-6601-2165 + + + + X distalmost_part_of Y <=> X is part_of Y and X is adjacent_to the distal boundary of Y + + @@ -2003,65 +2002,19 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 ?Y - lacks_part - - - - - - - - http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y) - lacks_plasma_membrane_part - - - - - - - - GOREL:0002003 - external - results_in_distribution_of - results_in_distribution_of - results in distribution of - results_in_distribution_of - - - - - - - - - GOREL:0002004 - external - results_in_fission_of - results_in_fission_of - results in fission of - results_in_fission_of - - - - inheres in - this fragility is a characteristic of this vase - this red color is a characteristic of this apple + this fragility inheres in this vase + this red color inheres in this apple a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence. + a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence + A dependent inheres in its bearer at all times for which the dependent exists. inheres_in - RO:0000052 - characteristic_of - Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing. characteristic of @@ -2076,12 +2029,15 @@ A continuant cannot have an occurrent as part: use 'participates in'. this apple is bearer of this red color this vase is bearer of this fragility Inverse of characteristic_of + a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist. bearer_of is bearer of RO:0000053 - has_characteristic + uberon + bearer_of + bearer_of has characteristic @@ -2103,7 +2059,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. uberon participates_in participates_in - participates in participates in @@ -2125,9 +2080,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. a relation between a process and a continuant, in which the continuant is somehow involved in the process Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. has_participant - http://www.obofoundry.org/ro/#OBO_REL:has_participant - RO:0000057 - has_participant + http://www.obofoundry.org/ro/#OBO_REL:has_participant has participant @@ -2139,14 +2092,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. - this catalysis function is a function of this enzyme a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence - A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists. - function_of - is function of - RO:0000079 - function_of - This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. function of @@ -2162,9 +2108,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. A quality inheres in its bearer at all times for which the quality exists. is quality of quality_of - RO:0000080 - quality_of - This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. quality of @@ -2180,9 +2123,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists. is role of role_of - RO:0000081 - role_of - This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. role of @@ -2194,12 +2134,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. - this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function) a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence - A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists. - has_function - RO:0000085 - has_function has function @@ -2215,10 +2150,11 @@ A continuant cannot have an occurrent as part: use 'participates in'. A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist. has_quality RO:0000086 + protein uberon has_quality + false has_quality - has quality has quality @@ -2235,6 +2171,10 @@ A continuant cannot have an occurrent as part: use 'participates in'. A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists. has_role RO:0000087 + chebi_ontology + has_role + false + false has_role has role @@ -2249,8 +2189,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence - RO:0000091 - has_disposition has disposition @@ -2261,10 +2199,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of has disposition - RO:0000092 - - disposition_of - This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. disposition of @@ -2275,23 +2209,43 @@ A continuant cannot have an occurrent as part: use 'participates in'. - is location of - my head is the location of my brain - this cage is the location of this rat a relation between two independent continuants, the location and the target, in which the target is entirely within the location - Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ - location_of - RO:0001015 uberon location_of location_of - location of location of + + + + + + + + + + + contained in + + + + + + + + RO:0001019 + uberon + contains + contains + contains + + + + @@ -2322,23 +2276,12 @@ A continuant cannot have an occurrent as part: use 'participates in'. - located in - my brain is located in my head - this rat is located in this cage a relation between two independent continuants, the target and the location, in which the target is entirely within the location - Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus - Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ - located_in - - http://www.obofoundry.org/ro/#OBO_REL:located_in RO:0001025 uberon located_in - located_in - located in located in - https://wiki.geneontology.org/Located_in @@ -2359,18 +2302,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. - the surface of my skin is a 2D boundary of my body a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity - A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts. - Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape. - 2D_boundary_of - boundary of - is 2D boundary of - is boundary of - surface of - - RO:0002000 - 2D_boundary_of 2D boundary of @@ -2381,20 +2313,11 @@ A continuant cannot have an occurrent as part: use 'participates in'. - my body has 2D boundary the surface of my skin a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity - A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts. - Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape. - - has boundary - has_2D_boundary - RO:0002002 uberon has_boundary - has_2D_boundary has_boundary - has 2D boundary has 2D boundary @@ -2404,19 +2327,14 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - http://www.ncbi.nlm.nih.gov/pubmed/22402613 RO:0002005 uberon innervated_by innervated_by - innervated_by innervated_by @@ -2447,14 +2365,11 @@ A continuant cannot have an occurrent as part: use 'participates in'. has_boundary: http://purl.obolibrary.org/obo/RO_0002002 boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - RO:0002007 uberon bounding_layer_of - bounding_layer_of - A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane. - bounding layer of + A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane. bounding layer of @@ -2466,10 +2381,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B. - + dos 2017-05-24T09:30:46Z - RO:0002013 - has_regulatory_component_activity has regulatory component activity @@ -2481,10 +2394,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B. - + dos 2017-05-24T09:31:01Z - RO:0002014 - has_negative_regulatory_component_activity By convention GO molecular functions are classified by their effector function. Internal regulatory functions are treated as components. For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'. has negative regulatory component activity @@ -2497,10 +2408,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B. - + dos 2017-05-24T09:31:17Z - RO:0002015 - has_positive_regulatory_component_activity By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'. has positive regulatory component activity @@ -2511,10 +2420,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - + dos 2017-05-24T09:44:33Z - RO:0002017 - has_component_activity A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B. has component activity @@ -2528,38 +2435,20 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. - + dos 2017-05-24T09:49:21Z - RO:0002018 - has_component_process has component process - - - - - A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization. - - 2017-07-20T17:19:37Z - RO:0002021 - occurs_across - occurs across - - - - - + dos 2017-09-17T13:52:24Z - RO:0002022 - directly_regulated_by Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. directly regulated by @@ -2567,7 +2456,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. - + GOC:dos @@ -2578,17 +2467,15 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1. - + dos 2017-09-17T13:52:38Z - RO:0002023 - directly_negatively_regulated_by directly negatively regulated by Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1. - + GOC:dos @@ -2599,17 +2486,15 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1. - + dos 2017-09-17T13:52:47Z - RO:0002024 - directly_positively_regulated_by directly positively regulated by Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1. - + GOC:dos @@ -2618,12 +2503,11 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 + A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity. - + dos 2017-09-22T14:14:36Z - RO:0002025 - has_effector_activity This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations. has effector activity @@ -2631,7 +2515,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity. - + GOC:dos @@ -2640,12 +2524,6 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - David Osumi-Sutherland - <= - RO:0002081 - - before_or_simultaneous_with - Primitive instance level timing relation between events before or simultaneous with @@ -2655,18 +2533,13 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - + + - x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time. - - David Osumi-Sutherland RO:0002082 uberon simultaneous_with - simultaneous_with - t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2) - simultaneous with simultaneous with @@ -2678,9 +2551,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 David Osumi-Sutherland - RO:0002086 - ends_after X ends_after Y iff: end(Y) before_or_simultaneous_with end(X) ends after @@ -2696,16 +2567,27 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 + X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) David Osumi-Sutherland starts_at_end_of RO:0002087 + directly preceded by + is directly preceded by + is immediately preceded by + starts_at_end_of uberon immediately_preceded_by immediately_preceded_by X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) - immediately preceded by immediately preceded by + + + + + is immediately preceded by + SIO:000251 + @@ -2717,135 +2599,17 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000 - David Osumi-Sutherland ends_at_start_of meets - RO:0002090 - immediately_precedes X immediately_precedes_Y iff: end(X) simultaneous_with start(Y) immediately precedes - - - - - - - - - - - - Relation between a neuron and a material anatomical entity that its soma is part of. - - <http://purl.obolibrary.org/obo/BFO_0000051> some ( - <http://purl.obolibrary.org/obo/GO_0043025> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y) - - RO:0002100 - has_soma_location - has soma location - - - - - - - - - - - - - - - - - - - - - - Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. - - - <http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0045211> that part_of some (<http://purl.obolibrary.org/obo/GO_0045202> that has_part some (<http://purl.obolibrary.org/obo/GO_0042734> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?))) - - - RO:0002103 - uberon - synapsed_by - synapsed_by - synapsed by - synapsed by - - - - - - - - - - - Every B cell[CL_0000236] has plasma membrane part some immunoglobulin complex[GO_0019814] - - Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part. - - - - - <http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0005886> and <http://purl.obolibrary.org/obo/BFO_0000051> some ?Y) - - RO:0002104 - has_plasma_membrane_part - has plasma membrane part - - - - - - - - - - - - - - - - - - - - - Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to. - - - - <http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0042734> that part_of some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0045211> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?))) - - - RO:0002120 - synapsed_to - N1 synapsed_to some N2 -Expands to: -N1 SubclassOf ( - has_part some ( - ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( - ‘synapse ; GO:0045202’ that has_part some ( - ‘post-synaptic membrane ; GO:0045211’ that part_of some N2)))) - synapsed to - - - - @@ -2904,24 +2668,17 @@ N1 SubclassOf ( - - Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - - <http://purl.obolibrary.org/obo/RO_0002132> some (<http://purl.obolibrary.org/obo/GO_0043005> that (<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?))) - - RO:0002134 uberon innervates innervates - innervates innervates @@ -2933,19 +2690,12 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - X continuous_with Y if and only if X and Y share a fiat boundary. - - connected to - The label for this relation was previously connected to. I relabeled this to "continuous with". The standard notion of connectedness does not imply shared boundaries - e.g. Glasgow connected_to Edinburgh via M8; my patella connected_to my femur (via patellar-femoral joint) - RO:0002150 uberon continuous_with continuous_with - continuous with continuous with - FMA:85972 @@ -2954,22 +2704,26 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - lactation SubClassOf 'only in taxon' some 'Mammalia' - + U only_in_taxon T: U is a feature found in only in organisms of species of taxon T. The feature cannot be found in an organism of any species outside of (not subsumed by) that taxon. Down-propagates in U hierarchy, up-propagates in T hierarchy (species taxonomy). Implies applicable_to_taxon. x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z. - The original intent was to treat this as a macro that expands to 'in taxon' only ?Y - however, this is not necessary if we instead have supplemental axioms that state that each pair of sibling tax have a disjointness axiom using the 'in taxon' property - e.g. - - 'in taxon' some Eukaryota DisjointWith 'in taxon' some Eubacteria - - - RO:0002160 + never_outside_taxon + specific_to + specific_to_taxon + protein uberon only_in_taxon + false only_in_taxon + Down-propagates. The original name for this in the paper is 'specific_to'. Applicable to genes because some genes are lost in sub-species (strains) of a species. only in taxon - + + + + U only_in_taxon T: U is a feature found in only in organisms of species of taxon T. The feature cannot be found in an organism of any species outside of (not subsumed by) that taxon. Down-propagates in U hierarchy, up-propagates in T hierarchy (species taxonomy). Implies applicable_to_taxon. + ROC:Waclaw + @@ -3028,10 +2782,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - - - - @@ -3060,20 +2810,12 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed. - - - - RO:0002162 uberon in_taxon - in_taxon - Connects a biological entity to its taxon of origin. in taxon - @@ -3099,18 +2841,22 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones). + Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship. a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b - RO:0002170 uberon connected_to connected_to - connected to + Connection does not imply overlaps. connected to - https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern - https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern + + + + + Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship. + + @@ -3124,19 +2870,21 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - The M8 connects Glasgow and Edinburgh - a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones). + Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship. c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system. - + this is currently used for both structural relationships (such as between a valve and the chamber it connects) and abstract relationships (anatomical lines and the entities they connect) RO:0002176 uberon connects connects - connects connects - https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern - https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern + + + + Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship. + + @@ -3144,22 +2892,30 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - - + + + + a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b. - attached to part of (anatomical structure to anatomical structure) RO:0002177 uberon attaches_to_part_of - attached_to_part_of attaches_to_part_of - attached to part of attached to part of + + + + + + + + true + @@ -3178,13 +2934,10 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy. - Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between an artery and an anatomical structure - RO:0002178 uberon supplies supplies - supplies supplies @@ -3196,13 +2949,13 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure. - Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between a vein and an anatomical structure - RO:0002179 + drains blood from + drains from uberon drains drains - drains + source: Wikipedia drains @@ -3218,11 +2971,12 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit. RO:0002180 + protein uberon has_component + false has_component - has component has component @@ -3238,18 +2992,24 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. + + + + x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y - - - - + Chris Mungall + Chris Mungall + David Osumi-Sutherland + David Osumi-Sutherland + Melissa Haendel + Terry Meehan + Terry Meehan RO:0002202 uberon develops_from develops_from This is the transitive form of the develops from relation - develops from develops from @@ -3264,10 +3024,12 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. inverse of develops from - - - + Chris Mungall + David Osumi-Sutherland + Terry Meehan RO:0002203 + uberon + develops_into develops_into develops into @@ -3280,35 +3042,11 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - - - - - - - - - - - - - - - - - Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y. - - - FBbt - RO:0002207 - has developmental precursor uberon directly_develops_from directly_develops_from - TODO - add child relations from DOS - directly develops from directly develops from @@ -3318,12 +3056,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - inverse of directly develops from - developmental precursor of - RO:0002210 - - directly_develops_into directly develops into @@ -3349,22 +3082,26 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q. - - - + + process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2. + We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit + Chris Mungall + David Hill + Tanya Berardini GO Regulation precludes parthood; the regulatory process may not be within the regulated process. regulates (processual) false RO:0002211 + external + regulates + regulates regulates - regulates (processual) @@ -3379,13 +3116,16 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q. - + Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2. + Chris Mungall negatively regulates (process to process) RO:0002212 + external + negatively_regulates + negatively_regulates @@ -3409,13 +3149,16 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q. - + Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2. + Chris Mungall positively regulates (process to process) RO:0002213 + external + positively_regulates + positively_regulates @@ -3428,22 +3171,27 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. + mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974) osteoclast SubClassOf 'capable of' some 'bone resorption' A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. - + Chris Mungall has function realized in For compatibility with BFO, this relation has a shortcut definition in which the expression "capable of some P" expands to "bearer_of (some realized_by only P)". + RO_0000053 some (RO_0000054 only ?Y) RO:0002215 + external + protein uberon capable_of + + false capable_of - capable of capable of @@ -3459,15 +3207,15 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. - + Chris Mungall has function in + RO_0000053 some (RO_0000054 only (BFO_0000050 some ?Y)) RO:0002216 uberon capable_of_part_of capable_of_part_of - capable of part of capable of part of - + @@ -3486,17 +3234,20 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x - - + x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y RO:0002219 uberon surrounded_by surrounded_by - surrounded by surrounded by + + + + x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y + + @@ -3506,32 +3257,16 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts. - The epidermis layer of a vertebrate is adjacent to the dermis. - The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies. - The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used. - x adjacent to y if and only if x and y share a boundary. - This relation acts as a join point with BSPO - - + x adjacent_to y iff: x and y share a boundary RO:0002220 spatial uberon adjacent_to - - - adjacent_to adjacent to adjacent to - - - - A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts. - - @@ -3539,18 +3274,20 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - inverse of surrounded by - - + inverse of surrounded_by RO:0002221 uberon surrounds - surrounds - surrounds surrounds + + + + inverse of surrounded_by + + @@ -3560,13 +3297,11 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - + Chris Mungall Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends. https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1 - RO:0002222 - temporally_related_to A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations. temporally related to @@ -3579,19 +3314,21 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - + Relation between occurrents, shares a start boundary with. inverse of starts with - - Chris Mungall - Allen RO:0002223 uberon starts - starts - starts starts + + + + Relation between occurrents, shares a start boundary with. + + Allen:starts + @@ -3601,18 +3338,11 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor - x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. - - Chris Mungall - started by RO:0002224 uberon starts_with - starts_with - starts with starts with @@ -3626,14 +3356,11 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - x develops from part of y if and only if there exists some z such that x develops from z and z is part of y - RO:0002225 uberon develops_from_part_of develops_from_part_of - develops from part of develops from part of @@ -3648,16 +3375,11 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - x develops_in y if x is located in y whilst x is developing - - EHDAA2 - Jonathan Bard, EHDAA2 RO:0002226 uberon develops_in develops_in - develops in develops in @@ -3669,18 +3391,23 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - + Relation between occurrents, shares an end boundary with. inverse of ends with - - Chris Mungall RO:0002229 + finishes uberon ends - ends - ends ends + + + + Relation between occurrents, shares an end boundary with. + + Allen:starts + ZFS:finishes + @@ -3690,17 +3417,11 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. - - Chris Mungall - finished by RO:0002230 uberon ends_with - ends_with - ends with ends with @@ -3716,13 +3437,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y - - starts with process that occurs in - RO:0002231 - - has_start_location has start location @@ -3738,13 +3453,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y - - ends with process that occurs in - RO:0002232 - - has_end_location has end location @@ -3756,22 +3465,20 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. + p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p. - + Chris Mungall consumes - RO:0002233 - has_input has input - https://wiki.geneontology.org/Has_input @@ -3785,51 +3492,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p. - - produces - RO:0002234 - - - - - has_output has output - https://wiki.geneontology.org/Has_output - - - - - - - - - - - In the tree T depicted in https://oborel.github.io/obo-relations/branching_part_of.png, B1 is connecting branch of S, and B1-1 as a connecting branch of B1. - b connecting-branch-of s iff b is connected to s, and there exists some tree-like structure t such that the mereological sum of b plus s is either the same as t or a branching-part-of t. - - RO:0002252 - uberon - connecting_branch_of - connecting_branch_of - connecting branch of - - - - - - - - - - inverse of connecting branch of - - RO:0002253 - - has_connecting_branch - has connecting branch @@ -3839,6 +3503,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. + @@ -3848,12 +3513,11 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.Mammalian thymus has developmental contribution from some pharyngeal pouch 3; Mammalian thymus has developmental contribution from some pharyngeal pouch 4 [Kardong] x has developmental contribution from y iff x has some part z such that z develops from y - + Chris Mungall RO:0002254 uberon has_developmental_contribution_from has_developmental_contribution_from - has developmental contribution from has developmental contribution from @@ -3870,8 +3534,10 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. inverse of has developmental contribution from - + Chris Mungall RO:0002255 + uberon + developmentally_contributes_to developmentally_contributes_to developmentally contributes to @@ -3884,25 +3550,21 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - - - - t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor material anatomical entity type T to T', where T' develops_from T - - - - induced by - - Developmental Biology, Gilbert, 8th edition, figure 6.5(F) - GO:0001759 - We place this under 'developmentally preceded by'. This placement should be examined in the context of reciprocal inductions[cjm] + t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T. + t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor anatomical structure type T to T', where T' develops_from T RO:0002256 uberon developmentally_induced_by developmentally_induced_by - developmentally induced by + sources for developmentally_induced_by relationships in Uberon: Developmental Biology, Gilbert, 8th edition, figure 6.5(F) developmentally induced by + + + + t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T. + GO:0001759 + @@ -3911,11 +3573,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - Inverse of developmentally induced by - - RO:0002257 - developmentally_induces developmentally induces @@ -3930,10 +3588,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p false - + Chris Mungall In general you should not use this relation to make assertions - use one of the more specific relations below this one - RO:0002258 - developmentally_preceded_by This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from developmentally preceded by @@ -3950,9 +3606,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision. c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes. - RO:0002263 - acts_upstream_of acts upstream of @@ -3969,12 +3623,10 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway. c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process. - RO:0002264 affects - acts_upstream_of_or_within acts upstream of or within - https://wiki.geneontology.org/Acts_upstream_of_or_within + @@ -3983,16 +3635,11 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else - This relation is intended for cases such as when we have a bone element replacing its cartilage element precursor. Currently most AOs represent this using 'develops from'. We need to decide whether 'develops from' will be generic and encompass replacement, or whether we need a new name for a generic relation that encompasses replacement and development-via-cell-lineage - - replaces RO:0002285 uberon developmentally_replaces developmentally_replaces - developmentally replaces developmentally replaces @@ -4004,9 +3651,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. Inverse of developmentally preceded by - - RO:0002286 - developmentally_succeeded_by + Chris Mungall developmentally succeeded by @@ -4020,131 +3665,22 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - 'hypopharyngeal eminence' SubClassOf 'part of precursor of' some tongue - - - RO:0002287 - part_of_developmental_precursor_of part of developmental precursor of - - - - - - - p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss). - This property and its subproperties are being used primarily for the definition of GO developmental processes. The property hierarchy mirrors the core GO hierarchy. In future we may be able to make do with a more minimal set of properties, but due to the way GO is currently structured we require highly specific relations to avoid incorrect entailments. To avoid this, the corresponding genus terms in GO should be declared mutually disjoint. - - RO:0002295 - results_in_developmental_progression_of - results in developmental progression of - - - - - - - - - - - every flower development (GO:0009908) results in development of some flower (PO:0009046) - - p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state. - - http://www.geneontology.org/GO.doc.development.shtml - RO:0002296 - - - - results_in_development_of - results in development of - - - - - - - - - - - an annotation of gene X to anatomical structure formation with results_in_formation_of UBERON:0000007 (pituitary gland) means that at the beginning of the process a pituitary gland does not exist and at the end of the process a pituitary gland exists. - every "endocardial cushion formation" (GO:0003272) results_in_formation_of some "endocardial cushion" (UBERON:0002062) - - - GOC:mtg_berkeley_2013 - RO:0002297 - - - - results_in_formation_of - results in formation of - - - - - - - - - - an annotation of gene X to cell morphogenesis with results_in_morphogenesis_of CL:0000540 (neuron) means that at the end of the process an input neuron has attained its shape. - tongue morphogenesis (GO:0043587) results in morphogenesis of tongue (UBERON:0001723) - - The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state. - - GOC:mtg_berkeley_2013 - RO:0002298 - - - - results_in_morphogenesis_of - results in morphogenesis of - - - - - - - - - - an annotation of gene X to cell maturation with results_in_maturation_of CL:0000057 (fibroblast) means that the fibroblast is mature at the end of the process - bone maturation (GO:0070977) results_in_maturation_of bone (UBERON:0001474) - - The relationship that links an entity with a process that results in the progression of the entity over time that is independent of changes in it's shape and results in an end point state of that entity. - - GOC:mtg_berkeley_2013 - RO:0002299 - - - - results_in_maturation_of - results in maturation of - - - - - p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q. - - RO:0002304 + cjm - causally_upstream_of,_positive_effect holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y causally upstream of, positive effect - @@ -4154,35 +3690,10 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q. - - RO:0002305 - - - causally_upstream_of,_negative_effect + cjm + holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y causally upstream of, negative effect - - - - - - - - - - - - an annotation of gene X to cell differentiation with results_in_maturation_of CL:0000057 (fibroblast) means that at the end of the process the input cell that did not have features of a fibroblast, now has the features of a fibroblast. - The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity - - GOC:mtg_berkeley_2013 - RO:0002315 - - - - results_in_acquisition_of_features_of - results in acquisition of features of @@ -4201,19 +3712,16 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. a particular instances of akt-2 enables some instance of protein kinase activity - c enables p iff c is capable of p and c acts to execute p. - + Chris Mungall catalyzes executes has is catalyzing is executing This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized. - RO:0002327 + This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time. - enables enables - https://wiki.geneontology.org/Enables @@ -4222,13 +3730,12 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities. - + Chris Mungall This is a grouping relation that collects relations used for the purpose of connecting structure and function RO:0002328 uberon functionally_related_to functionally_related_to - functionally related to functionally related to @@ -4243,10 +3750,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. this relation holds between c and p when c is part of some c', and c' is capable of p. - + Chris Mungall false - RO:0002329 - part_of_structure_that_is_capable_of part of structure that is capable of @@ -4275,13 +3780,11 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. c involved_in p if and only if c enables some process p', and p' is part of p - + Chris Mungall actively involved in enables part of - RO:0002331 - involved_in involved in - https://wiki.geneontology.org/Involved_in + @@ -4292,12 +3795,9 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. inverse of enables - - RO:0002333 + Chris Mungall - enabled_by enabled by - https://wiki.geneontology.org/Enabled_by @@ -4310,11 +3810,9 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. inverse of regulates - + Chris Mungall regulated by (processual) - RO:0002334 - regulated_by regulated by @@ -4325,10 +3823,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. inverse of negatively regulates - - RO:0002335 + Chris Mungall - negatively_regulated_by negatively regulated by @@ -4339,137 +3835,22 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. inverse of positively regulates - - RO:0002336 + Chris Mungall - positively_regulated_by positively regulated by - - - - - - A relationship that holds via some process of localization - - Do not use this relation directly. It is a grouping relation. - RO:0002337 - related_via_localization_to - related via localization to - - - - - - - - - - - - - This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination. - - RO:0002338 - - - - has_target_start_location - has target start location - - - - - - - - - - - - - This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l. - - RO:0002339 - - - - has_target_end_location - has target end location - - - - - - - - - Holds between p and l when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that is aligned_with l - - RO:0002341 - results_in_transport_along - results in transport along - - - - - - - - - - Holds between p and m when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that crosses m. - - RO:0002342 - - results_in_transport_across - results in transport across - - - - - - - - - - 'pollen tube growth' results_in growth_of some 'pollen tube' - - RO:0002343 - results_in_growth_of - results in growth of - - - - - - - - - 'mitochondrial transport' results_in_transport_to_from_or_in some mitochondrion (GO:0005739) - - RO:0002344 - results_in_transport_to_from_or_in - results in transport to from or in - - - - - An organism that is a member of a population of organisms is member of is a mereological relation between a item and a collection. - is member of - member part of - SIO - RO:0002350 + uberon + member_of member_of member of @@ -4482,13 +3863,10 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. has member is a mereological relation between a collection and an item. - SIO - RO:0002351 uberon has_member has_member - has member has member @@ -4500,14 +3878,13 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. inverse of has input - + Chris Mungall RO:0002352 uberon input_of input_of - input of input of @@ -4519,48 +3896,31 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. inverse of has output - RO:0002353 + protein uberon output_of - - + false output_of - output of output of - - - - - - RO:0002354 - formed_as_result_of - formed as result of - - - - + a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a - - attached to (anatomical structure to anatomical structure) RO:0002371 uberon attaches_to - - attached_to attaches_to - attached to attached to + @@ -4570,24 +3930,13 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to. - - Wikipedia:Insertion_(anatomy) RO:0002372 uberon has_muscle_origin has_muscle_origin - has muscle origin has muscle origin - - - - - - We need to import uberon muscle to create a stricter domain constraint - @@ -4596,24 +3945,13 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone. - - Wikipedia:Insertion_(anatomy) RO:0002373 uberon has_muscle_insertion has_muscle_insertion - has muscle insertion has muscle insertion - - - - - - We need to import uberon muscle into RO to use as a stricter domain constraint - @@ -4622,17 +3960,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - A relationship that holds between two material entities in a system of connected structures, where the branching relationship holds based on properties of the connecting network. - - Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving branching relationships - This relation can be used for geographic features (e.g. rivers) as well as anatomical structures (plant branches and roots, leaf veins, animal veins, arteries, nerves) - - RO:0002375 - in_branching_relationship_with in branching relationship with - - https://github.com/obophenotype/uberon/issues/170 @@ -4642,27 +3971,20 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - Deschutes River tributary_of Columbia River - inferior epigastric vein tributary_of external iliac vein - x tributary_of y if and only if x a channel for the flow of a substance into y, where y is larger than x. If x and y are hydrographic features, then y is the main stem of a river, or a lake or bay, but not the sea or ocean. If x and y are anatomical, then y is a vein. - - drains into - drains to - tributary channel of - http://en.wikipedia.org/wiki/Tributary - http://www.medindia.net/glossary/venous_tributary.htm - This relation can be used for geographic features (e.g. rivers) as well as anatomical structures (veins, arteries) RO:0002376 uberon + drains into tributary_of - tributary_of - tributary of tributary of - - http://en.wikipedia.org/wiki/Tributary + + + + drains into + dbpowl:drainsTo + @@ -4676,12 +3998,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - A lump of clay and a statue x spatially_coextensive_with y if and inly if x and y have the same location - - This relation is added for formal completeness. It is unlikely to be used in many practical scenarios - RO:0002379 - spatially_coextensive_with spatially coextensive with @@ -4699,18 +4016,14 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - In the tree T depicted in https://oborel.github.io/obo-relations/branching_part_of.png, B1 is a (direct) branching part of T. B1-1, B1-2, and B1-3 are also branching parts of T, but these are considered indirect branching parts as they do not directly connect to the main stem S x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y - + we need to check if FMA branch_of implies part_of. the relation we intend to use here should - for example, see vestibulocochlear nerve RO:0002380 uberon branching_part_of - branching_part_of - branching part of branching part of - - FMA:85994 + @@ -4722,9 +4035,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction). - - RO:0002384 - has_developmental_potential_involving + Chris Mungall has developmental potential involving @@ -4735,13 +4046,13 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. + x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y - + Chris Mungall RO:0002385 uberon has_potential_to_developmentally_contribute_to has_potential_to_developmentally_contribute_to - has potential to developmentally contribute to has potential to developmentally contribute to @@ -4751,11 +4062,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y - - RO:0002386 - has_potential_to_developmentally_induce has potential to developmentally induce @@ -4766,13 +4073,13 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. + x has the potential to develop into y iff x develops into y or if x is capable of developing into y x has the potential to develop into y iff x develops into y or if x is capable of developing into y - + Chris Mungall RO:0002387 uberon has_potential_to_develop_into has_potential_to_develop_into - has potential to develop into has potential to develop into @@ -4784,9 +4091,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y - - RO:0002388 - has_potential_to_directly_develop_into + Chris Mungall has potential to directly develop into @@ -4800,9 +4105,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. inverse of upstream of - - RO:0002404 - causally_downstream_of + Chris Mungall causally downstream of @@ -4815,90 +4118,23 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - - RO:0002405 - immediately_causally_downstream_of + Chris Mungall immediately causally downstream of - - - - - - - - - - - - - - - - - - - - - - - p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q. - - indirectly activates - - RO:0002407 - indirectly_positively_regulates - indirectly positively regulates - https://wiki.geneontology.org/Indirectly_positively_regulates - - - - - - - - - - - - - - - - - - - - - - - p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q. - - indirectly inhibits - - RO:0002409 - indirectly_negatively_regulates - indirectly negatively regulates - https://wiki.geneontology.org/Indirectly_negatively_regulates - - - - - p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q. - - RO:0002411 + + p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain + Chris Mungall - causally_upstream_of causally upstream of @@ -4909,11 +4145,10 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q. - + + p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q. + Chris Mungall - RO:0002412 - immediately_causally_upstream_of immediately causally upstream of @@ -4925,13 +4160,11 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q. + p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q. We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2 - + Chris Mungall influences (processual) - RO:0002418 affects - causally_upstream_of_or_within causally upstream of or within @@ -4943,11 +4176,9 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. inverse of causally upstream of or within - + Chris Mungall - RO:0002427 - causally_downstream_of_or_within causally downstream of or within @@ -4967,9 +4198,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. c involved in regulation of p if c is involved in some p' and p' regulates some p - - RO:0002428 - involved_in_regulation_of + Chris Mungall involved in regulation of @@ -4988,10 +4217,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. c involved in regulation of p if c is involved in some p' and p' positively regulates some p - + Chris Mungall - RO:0002429 - involved_in_positive_regulation_of involved in positive regulation of @@ -5010,10 +4237,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. c involved in regulation of p if c is involved in some p' and p' negatively regulates some p - + Chris Mungall - RO:0002430 - involved_in_negative_regulation_of involved in negative regulation of @@ -5027,10 +4252,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p OWL does not allow defining object properties via a Union - + Chris Mungall involved in or reguates - RO:0002431 - involved_in_or_involved_in_regulation_of involved in or involved in regulation of @@ -5047,14 +4270,11 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. A protein that enables activity in a cytosol. c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure. - + Chris Mungall executes activity in - RO:0002432 enables activity in - is_active_in is active in - https://wiki.geneontology.org/Is_active_in @@ -5069,8 +4289,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure. - - + GOC:cjm + GOC:dos @@ -5080,7 +4300,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm. - RO:0002433 uberon contributes_to_morphology_of @@ -5099,15 +4318,13 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.A relationship that holds between two entities in which the processes executed by the two entities are causally connected. Considering relabeling as 'pairwise interacts with' This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact. - + Chris Mungall Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules. - RO:0002434 in pairwise interaction with - interacts_with interacts with - http://purl.obolibrary.org/obo/ro/docs/interaction-relations/ - http://purl.obolibrary.org/obo/MI_0914 + http://purl.obolibrary.org/obo/MI_0914 + https://github.com/oborel/obo-relations/wiki/InteractionRelations @@ -5118,14 +4335,12 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other. - + Chris Mungall binds molecularly binds with - RO:0002436 - molecularly_interacts_with molecularly interacts with - http://purl.obolibrary.org/obo/MI_0915 + http://purl.obolibrary.org/obo/MI_0915 @@ -5135,10 +4350,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. Axiomatization to GO to be added later - + Chris Mungall An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y. - RO:0002447 - phosphorylates phosphorylates @@ -5159,11 +4372,9 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B. - - - RO:0002448 + Chris Mungall + Vasundra Touré molecularly controls - directly_regulates_activity_of directly regulates activity of @@ -5182,12 +4393,10 @@ A and B can be physically interacting but not necessarily. Immediately upstream The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B. - - + Chris Mungall + Vasundra Touré directly inhibits - RO:0002449 molecularly decreases activity of - directly_negatively_regulates_activity_of directly negatively regulates activity of @@ -5206,12 +4415,10 @@ For example, A and B may be gene products and binding of B by A negatively regul The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B. - - + Chris Mungall + Vasundra Touré directly activates - RO:0002450 molecularly increases activity of - directly_positively_regulates_activity_of directly positively regulates activity of @@ -5223,15 +4430,12 @@ For example, A and B may be gene products and binding of B by A positively regul - 'otolith organ' SubClassOf 'composed primarily of' some 'calcium carbonate' x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y. - - - + x composed_primarily_of y iff: more than half of the mass of x is made from parts of y RO:0002473 uberon + RO:0002473 composed_primarily_of - composed_primarily_of composed primarily of @@ -5248,10 +4452,8 @@ For example, A and B may be gene products and binding of B by A positively regul p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c. - - RO:0002479 + Chris Mungall - has_part_that_occurs_in has part that occurs in @@ -5266,42 +4468,11 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - - See notes for inverse relation - - RO:0002485 - receives_input_from - receives input from - - - - - - - - - This is an exploratory relation. The label is taken from the FMA. It needs aligned with the neuron-specific relations such as has postsynaptic terminal in. - - RO:0002486 - sends_output_to - sends output to - - - - - - Do not use this relation directly. It is ended as a grouping for a diverse set of relations, typically connecting an anatomical entity to a biological process or developmental stage. - RO:0002487 - relation_between_physical_entity_and_a_process_or_stage relation between physical entity and a process or stage @@ -5316,14 +4487,22 @@ For example, A and B may be gene products and binding of B by A positively regul + Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s. x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y). - RO:0002488 + begins_to_exist_during uberon + RO:0002488 existence_starts_during existence_starts_during existence starts during + + + + Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s. + + @@ -5331,14 +4510,20 @@ For example, A and B may be gene products and binding of B by A positively regul + Relation between continuant and occurrent, such that c comes into existence at the start of p. x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y). - RO:0002489 uberon existence_starts_with existence_starts_with existence starts with + + + + Relation between continuant and occurrent, such that c comes into existence at the start of p. + + @@ -5347,10 +4532,6 @@ For example, A and B may be gene products and binding of B by A positively regul x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y)) - - RO:0002490 - existence_overlaps - The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. existence overlaps @@ -5362,13 +4543,10 @@ For example, A and B may be gene products and binding of B by A positively regul x exists during y if and only if: 1) the time point at which x begins to exist is after or equal to the time point at which y begins and 2) the time point at which x ceases to exist is before or equal to the point at which y ends. Formally: x existence starts and ends during y iff α(x) >= α(y) & α(x) <= ω(y) & ω(x) <= ω(y) & ω(x) >= α(y) - RO:0002491 - exists during uberon existence_starts_and_ends_during existence_starts_and_ends_during - The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. existence starts and ends during @@ -5385,20 +4563,19 @@ For example, A and B may be gene products and binding of B by A positively regul Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely. x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y). - RO:0002492 ceases_to_exist_during uberon + RO:0002492 existence_ends_during existence_ends_during - The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. existence ends during Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely. - https://orcid.org/0000-0002-6601-2165 + @@ -5407,15 +4584,20 @@ For example, A and B may be gene products and binding of B by A positively regul + Relation between continuant and occurrent, such that c ceases to exist at the end of p. x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y). - RO:0002493 uberon existence_ends_with existence_ends_with - The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. existence ends with + + + + Relation between continuant and occurrent, such that c ceases to exist at the end of p. + + @@ -5425,13 +4607,20 @@ For example, A and B may be gene products and binding of B by A positively regul x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships - RO:0002494 + transforms from uberon transformation_of transformation_of transformation of + + + + + transforms from + SIO:000657 + @@ -5441,14 +4630,27 @@ For example, A and B may be gene products and binding of B by A positively regul x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t - - RO:0002495 + direct_transformation_of + immediately transforms from uberon immediate_transformation_of immediate_transformation_of immediate transformation of + + + + + direct_transformation_of + + + + + + immediately transforms from + SIO:000658 + @@ -5477,12 +4679,10 @@ For example, A and B may be gene products and binding of B by A positively regul x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y). - RO:0002496 uberon existence_starts_during_or_after existence_starts_during_or_after - The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. existence starts during or after @@ -5513,12 +4713,10 @@ For example, A and B may be gene products and binding of B by A positively regul x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends. - RO:0002497 uberon existence_ends_during_or_before existence_ends_during_or_before - The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. existence ends during or before @@ -5531,8 +4729,6 @@ For example, A and B may be gene products and binding of B by A positively regul A relationship between a material entity and a process where the material entity has some causal role that influences the process - RO:0002500 - causal_agent_in_process causal agent in process @@ -5543,12 +4739,10 @@ For example, A and B may be gene products and binding of B by A positively regul - p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q. - + p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q. + Chris Mungall Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. - RO:0002501 - causal_relation_between_processes causal relation between processes @@ -5560,11 +4754,9 @@ For example, A and B may be gene products and binding of B by A positively regul The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch - + Chris Mungall Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. - RO:0002506 - causal_relation_between_entities causal relation between entities @@ -5577,26 +4769,23 @@ For example, A and B may be gene products and binding of B by A positively regul - - - Forelimb SubClassOf has_skeleton some 'Forelimb skeleton' A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision. - - has supporting framework - The skeleton of a structure may be a true skeleton (for example, the bony skeleton of a hand) or any kind of support framework (the hydrostatic skeleton of a sea star, the exoskeleton of an insect, the cytoskeleton of a cell). + A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision. RO:0002551 uberon + has sekeletal support + has supporting framework has_skeleton has_skeleton has skeleton - - - This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional. + + A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision. + @@ -5606,11 +4795,9 @@ For example, A and B may be gene products and binding of B by A positively regul - + Chris Mungall causally influenced by (entity-centric) - RO:0002559 - causally_influenced_by causally influenced by @@ -5633,12 +4820,10 @@ For example, A and B may be gene products and binding of B by A positively regul The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size). - - + Chris Mungall + Vasundra Touré causally influences (entity-centric) - RO:0002566 - causally_influences causally influences @@ -5648,13 +4833,7 @@ For example, A and B may be gene products and binding of B by A positively regul - - A relation that holds between elements of a musculoskeletal system or its analogs. - - Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the biomechanical processes. - RO:0002567 - biomechanically_related_to biomechanically related to @@ -5665,8 +4844,6 @@ For example, A and B may be gene products and binding of B by A positively regul m1 has_muscle_antagonist m2 iff m1 has_muscle_insertion s, m2 has_muscle_insection s, m1 acts in opposition to m2, and m2 is responsible for returning the structure to its initial position. - - Wikipedia:Antagonist_(muscle) RO:0002568 uberon has_muscle_antagonist @@ -5683,50 +4860,24 @@ For example, A and B may be gene products and binding of B by A positively regul inverse of branching part of - RO:0002569 uberon has_branching_part - - has_branching_part has branching part - - - - - - - x is a conduit for y iff y overlaps through the lumen_of of x, and y has parts on either side of the lumen of x. - - UBERON:cjm - This relation holds between a thing with a 'conduit' (e.g. a bone foramen) and a 'conduee' (for example, a nerve) such that at the time the relationship holds, the conduee has two ends sticking out either end of the conduit. It should therefore note be used for objects that move through the conduit but whose spatial extent does not span the passage. For example, it would not be used for a mountain that contains a long tunnel through which trains pass. Nor would we use it for a digestive tract and objects such as food that pass through. - RO:0002570 - uberon - conduit_for - - conduit_for - conduit for - - - - x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull. - - RO:0002571 uberon lumen_of - lumen_of lumen of @@ -5736,14 +4887,13 @@ For example, A and B may be gene products and binding of B by A positively regul + s is luminal space of x iff s is lumen_of x and s is an immaterial entity - RO:0002572 uberon luminal_space_of - luminal_space_of luminal space of @@ -5754,14 +4904,10 @@ For example, A and B may be gene products and binding of B by A positively regul - - inverse of has skeleton - RO:0002576 uberon skeleton_of - skeleton_of skeleton of @@ -5773,16 +4919,14 @@ For example, A and B may be gene products and binding of B by A positively regul - p directly regulates q iff p is immediately causally upstream of q and p regulates q. - + Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. + Chris Mungall directly regulates (processual) - RO:0002578 - directly_regulates directly regulates @@ -5799,65 +4943,12 @@ For example, A and B may be gene products and binding of B by A positively regul gland SubClassOf 'has part structure that is capable of' some 'secretion by cell' s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p - - RO:0002584 - has_part_structure_that_is_capable_of + Chris Mungall has part structure that is capable of - - - - - p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p - RO:0002586 - results_in_breakdown_of - results in breakdown of - - - - - - - - - - RO:0002588 - - - - results_in_assembly_of - results in assembly of - - - - - - - - - - RO:0002590 - results_in_disassembly_of - results in disassembly of - - - - - - - - - p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c - RO:0002592 - results_in_organization_of - results in organization of - - - - @@ -5865,10 +4956,8 @@ For example, A and B may be gene products and binding of B by A positively regul A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity. Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. - + Chris Mungall - RO:0002595 - causal_relation_between_material_entity_and_a_process causal relation between material entity and a process @@ -5885,8 +4974,6 @@ For example, A and B may be gene products and binding of B by A positively regul pyrethroid -> growth Holds between c and p if and only if c is capable of some activity a, and a regulates p. - RO:0002596 - capable_of_regulating capable of regulating @@ -5902,8 +4989,6 @@ For example, A and B may be gene products and binding of B by A positively regul Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p. - RO:0002597 - capable_of_negatively_regulating capable of negatively regulating @@ -5920,8 +5005,6 @@ For example, A and B may be gene products and binding of B by A positively regul renin -> arteriolar smooth muscle contraction Holds between c and p if and only if c is capable of some activity a, and a positively regulates p. - RO:0002598 - capable_of_positively_regulating capable of positively regulating @@ -5932,8 +5015,6 @@ For example, A and B may be gene products and binding of B by A positively regul Inverse of 'causal agent in process' - RO:0002608 - process_has_causal_agent process has causal agent @@ -5944,17 +5025,14 @@ For example, A and B may be gene products and binding of B by A positively regul - p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q. + Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2. directly positively regulates (process to process) - RO:0002629 - directly_positively_regulates directly positively regulates - https://wiki.geneontology.org/Directly_positively_regulates @@ -5964,17 +5042,14 @@ For example, A and B may be gene products and binding of B by A positively regul - p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q. + Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2. directly negatively regulates (process to process) - RO:0002630 - directly_negatively_regulates directly negatively regulates - https://wiki.geneontology.org/Directly_negatively_regulates @@ -5991,16 +5066,11 @@ For example, A and B may be gene products and binding of B by A positively regul - a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix. - RO:0003000 uberon produces - produces - Note that this definition doesn't quite distinguish the output of a transformation process from a production process, which is related to the identity/granularity issue. - produces produces @@ -6011,87 +5081,16 @@ For example, A and B may be gene products and binding of B by A positively regul - a produced_by b iff some process that occurs_in b has_output a. - RO:0003001 uberon produced_by - produced_by - produced by produced by - - - - - p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c. - - 2018-12-13T11:26:17Z - RO:0004007 - - has_primary_input_or_output - has primary input or output - - - - - - - - - - p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c. - - 2018-12-13T11:26:32Z - RO:0004008 - - has_primary_output - has primary output - - - - - p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c. - - GOC:dph - GOC:kva - GOC:pt - PMID:27812932 - - - - - - - - - - p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c. - - 2018-12-13T11:26:56Z - RO:0004009 - - has_primary_input - has primary input - - - - - p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c. - - GOC:dph - GOC:kva - GOC:pt - PMID:27812932 - - - - @@ -6101,10 +5100,8 @@ For example, A and B may be gene products and binding of B by A positively regul Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P. - + cjm 2018-01-25T23:20:13Z - RO:0004031 - enables_subfunction enables subfunction @@ -6119,13 +5116,11 @@ For example, A and B may be gene products and binding of B by A positively regul - + cjm 2018-01-26T23:49:30Z - RO:0004032 - acts_upstream_of_or_within,_positive_effect acts upstream of or within, positive effect - https://wiki.geneontology.org/Acts_upstream_of_or_within,_positive_effect + @@ -6139,13 +5134,10 @@ For example, A and B may be gene products and binding of B by A positively regul - + cjm 2018-01-26T23:49:51Z - RO:0004033 - acts_upstream_of_or_within,_negative_effect acts upstream of or within, negative effect - https://wiki.geneontology.org/Acts_upstream_of_or_within,_negative_effect @@ -6161,13 +5153,11 @@ For example, A and B may be gene products and binding of B by A positively regul c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive - + cjm 2018-01-26T23:53:14Z - RO:0004034 - acts_upstream_of,_positive_effect acts upstream of, positive effect - https://wiki.geneontology.org/Acts_upstream_of,_positive_effect + @@ -6183,13 +5173,11 @@ For example, A and B may be gene products and binding of B by A positively regul c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative - + cjm 2018-01-26T23:53:22Z - RO:0004035 - acts_upstream_of,_negative_effect acts upstream of, negative effect - https://wiki.geneontology.org/Acts_upstream_of,_negative_effect + @@ -6199,12 +5187,9 @@ For example, A and B may be gene products and binding of B by A positively regul - + cjm 2018-03-13T23:55:05Z - RO:0004046 - causally_upstream_of_or_within,_negative_effect causally upstream of or within, negative effect - https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect @@ -6214,12 +5199,9 @@ For example, A and B may be gene products and binding of B by A positively regul - + cjm 2018-03-13T23:55:19Z - RO:0004047 - causally_upstream_of_or_within,_positive_effect causally upstream of or within, positive effect - @@ -6231,134 +5213,12 @@ For example, A and B may be gene products and binding of B by A positively regul The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B. - - RO:0011002 - regulates_activity_of + Vasundra Touré regulates activity of - - - - - p acts on population of c iff c' is a collection, has members of type c, and p has participant c - - 2020-06-08T17:21:33Z - RO:0012003 - - - - acts_on_population_of - acts on population of - - - - - - - - - - 2021-02-26T07:28:29Z - RO:0012008 - - - - results_in_fusion_of - results in fusion of - - - - - - - - - p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q. - - 2022-09-26T06:07:17Z - RO:0012011 - indirectly_causally_upstream_of - indirectly causally upstream of - - - - - - - - - - p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q. - - 2022-09-26T06:08:01Z - RO:0012012 - indirectly_regulates - indirectly regulates - - - - - - - - - - q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - RO:0015006 - different_in_magnitude_relative_to - different in magnitude relative to - - - - - q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - https://orcid.org/0000-0002-6601-2165 - - - - - - - - - - - q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - RO:0015007 - increased_in_magnitude_relative_to - This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'. - increased in magnitude relative to - - - - - q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. - https://orcid.org/0000-0002-6601-2165 - - - - - - - - s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2. - RO:0015011 - has_cross_section - Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round. - has cross section - - - - - s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2. - https://orcid.org/0000-0002-6601-2165 - - - - @@ -6369,9 +5229,6 @@ For example, A and B may be gene products and binding of B by A positively regul A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C. - - RO:0019000 - regulates_characteristic regulates characteristic @@ -6386,9 +5243,6 @@ For example, A and B may be gene products and binding of B by A positively regul A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C. - - RO:0019001 - positively_regulates_characteristic positively regulates characteristic @@ -6407,79 +5261,19 @@ For example, A and B may be gene products and binding of B by A positively regul A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C. - - RO:0019002 - negatively_regulates_characteristic negatively regulates characteristic - - - - - p has anatomical participant c iff p has participant c, and c is an anatomical entity - - 2018-09-26T01:08:58Z - RO:0040036 - results_in_changes_to_anatomical_or_cellular_structure - results in changes to anatomical or cellular structure - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + protein + has_gene_template + false + has_gene_template + @@ -6497,7 +5291,7 @@ For example, A and B may be gene products and binding of B by A positively regul x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y. - http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern + @@ -6537,6 +5331,17 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + x is a conduit for y iff y passes through the lumen of x. + uberon + conduit_for + conduit for + + + + @@ -6551,7 +5356,7 @@ For example, A and B may be gene products and binding of B by A positively regul x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y. - http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern + @@ -6561,17 +5366,10 @@ For example, A and B may be gene products and binding of B by A positively regul - X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y uberon extends_fibers_into extends_fibers_into - - - - X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y - https://orcid.org/0000-0002-7073-9172 - @@ -6633,7 +5431,7 @@ For example, A and B may be gene products and binding of B by A positively regul x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y. - http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern + @@ -6661,7 +5459,7 @@ For example, A and B may be gene products and binding of B by A positively regul x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y. - http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern + @@ -6689,6 +5487,17 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. + uberon + synapsed_by + synapsed by + + + + + - - - - - - - - - gdc - GenericallyDependentContinuant - The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity. - the pdf file on your laptop, the pdf file that is a copy thereof on my laptop - the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule. - b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) - (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] - A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time. - - generically dependent continuant + + + fiat object part + + + + + + + + + bfo + BFO:0000030 + object + object - - - - b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) - - - - - - (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] - - @@ -7333,76 +6009,12 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - - - - material - MaterialEntity - a flame - a forest fire - a human being - a hurricane - a photon - a puff of smoke - a sea wave - a tornado - an aggregate of human beings. - an energy wave - an epidemic - the undetached arm of a human being An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time. - BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60 - BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity. - BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here. - A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002]) - Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002]) - every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002]) - (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] - (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] - (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] - + bfo + BFO:0000040 + material entity material entity - - - - A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002]) - - - - - - Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002]) - - - - - - every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002]) - - - - - - (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] - - - - - - (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] - - - - - - (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] - - @@ -7410,12 +6022,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - - - immaterial ImmaterialEntity BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10 @@ -7425,9 +6031,19 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + biological entity + + + + + Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV. -1 0.000548579903 @@ -7453,7 +6069,7 @@ For example, A and B may be gene products and binding of B by A positively regul PMID:21614077 - Europe PMC + Europe PMC @@ -7529,218960 +6145,34878 @@ For example, A and B may be gene products and binding of B by A positively regul - A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens. - chebi_ontology - dicarboxylic acids and derivatives - CHEBI:131927 - dicarboxylic acids and O-substituted derivatives - - - - dicarboxylic acids and derivatives - ChEBI - - + + + + + 24G7 epitope + + + + + + + + + + polypeptide + + + + + + + + + + hyaluronic acid + + + + + - - - + + - - + + - A carbohydrate acid derivative anion obtained by deprotonation of the carboxy groups of hyaluronic acid; major species at pH 7.3. - -1 - (C14H20NO11)n.H2O + protein polypeptide chain + + + + + + + + + + + + + + + + peptide + + + + + + + + + glycan + + + + + + + + + + + + + + + + bilirubin IXalpha + + + + + + + + + + glycoprotein + + + + + + + + + lipid + + + + + + + + + glycosaminoglycan + + + + + + + + + acyl group + + + + + + + + + + + alkali metal atom + + + + + + + + + + aminoglycan + + + + + + + + + anion + + + + + + + + + + bile salt + + + + + + + + + carbamoyl group + + + + + + + + + carbonyl group + + + + + + + + + Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. chebi_ontology - hyaluronan - hyaluronate polyanion - CHEBI:132153 - - hyaluronate + CHEBI:23367 + molecular entity - - - hyaluronan - UniProt - - - - - hyaluronate polyanion - ChEBI + + + Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. + fake:2 - + + + + + + monoatomic cation + + - - - Any steroid that has beta-configuration at position 5. + + + + + + A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. + chemical entity chebi_ontology - 5beta steroids - 5beta-steroid - 5beta-steroids - CHEBI:136889 + CHEBI:24431 - 5beta steroid + chemical entity - - - 5beta steroids - ChEBI - - - - - 5beta-steroid - ChEBI - - - - - 5beta-steroids - ChEBI + + + chemical entity + UniProt - + - - - A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water. - Wikipedia:Mineral_acid + + + A role played by the molecular entity or part thereof within a biological context. chebi_ontology - inorganic acids - mineral acid - mineral acids - CHEBI:138103 + biological function + CHEBI:24432 - inorganic acid + biological role - - - inorganic acids - ChEBI - - - - - mineral acid - ChEBI - - - + - mineral acids + biological function ChEBI - + - - - - - Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration. - chebi_ontology - CHEBI:138366 - - bile acids + + + + + + + + + group - + - - - Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa). - Wikipedia:https://en.wikipedia.org/wiki/Gas - chebi_ontology - gas molecular entities - gaseous molecular entities - gaseous molecular entity - CHEBI:138675 - - gas molecular entity + + + + + organic heterocyclic compound - - - - gas molecular entities - ChEBI - - - - - gaseous molecular entities - ChEBI - - - - - gaseous molecular entity - ChEBI - - + - - + + + + - - + + - -1 - CH2NO2 - InChI=1S/CH3NO2/c2-1(3)4/h2H2,(H,3,4)/p-1 - KXDHJXZQYSOELW-UHFFFAOYSA-M - 60.03212 - 60.00910 - NC([O-])=O - Beilstein:3903503 - CAS:302-11-4 - Gmelin:239604 - carbamate + hydroxides + + + + + + + + + oxoacid + + + + + + + + + inorganic molecular entity + + + + + + + + + + + + + + + + + + + + + salt + + + + + + + + + + monoatomic ion + + + + + + + + + organic salt + + + + + + + + + ion + + + + + + + + + linear tetrapyrrole + + + + + + + + + + metal cation + + + + + + + + + molecule + + + + + + + + + monoatomic monocation + + + + + + + + + + nitrogen atom + + + + + + + + + nonmetal chebi_ontology - Carbamat - Karbamat - carbamate ion - carbamic acid, ion(1-) - CHEBI:13941 + Nichtmetall + Nichtmetalle + no metal + no metales + non-metal + non-metaux + nonmetal + nonmetals + CHEBI:25585 - carbamate + nonmetal atom - - - Beilstein:3903503 - Beilstein + + + nonmetal + IUPAC + - - - CAS:302-11-4 - ChemIDplus + + + Nichtmetall + ChEBI - - - Gmelin:239604 - Gmelin + + + Nichtmetalle + ChEBI - - - carbamate - IUPAC - + + + no metal + ChEBI - - - carbamate - UniProt + + + no metales + ChEBI - + - Carbamat + non-metal ChEBI - + - Karbamat + non-metaux ChEBI - + - carbamate ion - ChemIDplus + nonmetal + ChEBI - + - carbamic acid, ion(1-) - ChemIDplus + nonmetals + ChEBI - + - - - + + + organic sulfate + + + + + + + + + - + - An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22. 0 - C7H6N2O - 134.136 - 134.04801 - C(=CC(NC(=*)*)=*)(NC(C(C)=*)=O)* - chebi_ontology - CHEBI:142163 - - 24G7 epitope - - - - - - - - - A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity. - CHEBI:13699 - CHEBI:2377 - KEGG:C00028 - KEGG:C16722 - Acceptor + O + InChI=1S/O + QVGXLLKOCUKJST-UHFFFAOYSA-N + 15.99940 + 15.99491 + [O] + KEGG:C00007 + WebElements:O + oxygen chebi_ontology - A - Akzeptor - Hydrogen-acceptor - Oxidized donor - accepteur - CHEBI:15339 + 8O + O + Sauerstoff + oxigeno + oxygen + oxygene + CHEBI:25805 - acceptor + oxygen atom - + - Acceptor - KEGG_COMPOUND + oxygen + IUPAC + - + - A - KEGG_COMPOUND + 8O + IUPAC + + + + + O + IUPAC - + - Akzeptor + Sauerstoff ChEBI - + - Hydrogen-acceptor - KEGG_COMPOUND + oxigeno + ChEBI - + - Oxidized donor - KEGG_COMPOUND + oxygen + ChEBI - + - accepteur + oxygene ChEBI - + - - - - - - - - - - + + - - + + + oxygen molecular entity + + + + + + + + + sodium atom + + + + + + + + - - + + + sodium molecular entity + + + + + + + + + - - + + + sodium salt + + + + + + + + + + sulfuric ester + + + + + + + + + sulfates + + + + + + + + + + sulfur atom + + + + + + + + - - + + - - - - - - - Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter. - +1 - C7H16NO2 - InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 - OIPILFWXSMYKGL-UHFFFAOYSA-N - 146.20748 - 146.11756 - CC(=O)OCC[N+](C)(C)C - CHEBI:12686 - CHEBI:13715 - CHEBI:22197 - CHEBI:2416 - CHEBI:40559 - Beilstein:1764436 - CAS:51-84-3 - DrugBank:DB03128 - Drug_Central:65 - Gmelin:326108 - KEGG:C01996 - LINCS:LSM-5888 - PDBeChem:ACH - PMID:14764638 - PMID:15014918 - PMID:15231705 - PMID:15361288 - PMID:18050502 - PMID:18407448 - PMID:19255787 - PMID:20963497 - PMID:21130809 - PMID:21246223 - PMID:21545631 - PMID:21601579 - Wikipedia:Acetylcholine - 2-acetyloxy-N,N,N-trimethylethanaminium - ACETYLCHOLINE - Acetylcholine - acetylcholine + sulfur molecular entity + + + + + + + + + + tetrapyrrole + + + + + + + + + univalent carboacyl group + + + + + + + + + + carbon atom + + + + + + + + + + + + sodium(1+) + + + + + + + + + amide + + + + + + + + + A particle not known to have substructure. + elementary particle chebi_ontology - ACh - Azetylcholin - O-Acetylcholine - choline acetate - CHEBI:15355 + elementary particles + CHEBI:33233 - acetylcholine + fundamental particle - - - Beilstein:1764436 - ChemIDplus - - - - - CAS:51-84-3 - ChemIDplus - - - - - CAS:51-84-3 - KEGG COMPOUND - - - - - Drug_Central:65 - DrugCentral - - - - - Gmelin:326108 - Gmelin - - - - - PMID:14764638 - Europe PMC - - - - - PMID:15014918 - Europe PMC - - - - - PMID:15231705 - Europe PMC - - - - - PMID:15361288 - Europe PMC - - - - - PMID:18050502 - Europe PMC - - - - - PMID:18407448 - Europe PMC - - - - - PMID:19255787 - Europe PMC - - - - - PMID:20963497 - Europe PMC - - - - - PMID:21130809 - Europe PMC - - - - - PMID:21246223 - Europe PMC - - - - - PMID:21545631 - Europe PMC - - - - - PMID:21601579 - Europe PMC - - - + - 2-acetyloxy-N,N,N-trimethylethanaminium + elementary particle IUPAC - - - ACETYLCHOLINE - PDBeChem - - - - - Acetylcholine - KEGG_COMPOUND - - - - - acetylcholine - UniProt - - - + - ACh - ChemIDplus - - - - - Azetylcholin + elementary particles ChEBI - - - - O-Acetylcholine - KEGG_COMPOUND - - - - - choline acetate - ChemIDplus - - + - - - - - - - - - - - - - - - - - - - - + + + monoatomic entity + + + + + + + + + oxoacid derivative + + + + + + + + + inorganic group + + + + + + + + + + Any substituent group or skeleton containing carbon. + chebi_ontology + CHEBI:33247 + organic group + + + + + + + + + organyl group + + + + + + + + - - + + - - + + - A simple monocarboxylic acid containing two carbons. - 0 - C2H4O2 - InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4) - QTBSBXVTEAMEQO-UHFFFAOYSA-N - 60.05200 - 60.02113 - CC(O)=O - CHEBI:22169 - CHEBI:2387 - CHEBI:40486 - Beilstein:506007 - CAS:64-19-7 - Drug_Central:4211 - Gmelin:1380 - HMDB:HMDB0000042 - KEGG:C00033 - KEGG:D00010 - KNApSAcK:C00001176 - LIPID_MAPS_instance:LMFA01010002 - MetaCyc:ACET - PDBeChem:ACT - PDBeChem:ACY - PMID:12005138 - PMID:15107950 - PMID:16630552 - PMID:16774200 - PMID:17190852 - PMID:19416101 - PMID:19469536 - PMID:22153255 - PMID:22173419 - PPDB:1333 - Reaxys:506007 - Wikipedia:Acetic_acid - ACETIC ACID - Acetic acid - acetic acid + A chemical entity constituting the smallest component of an element having the chemical properties of the element. + CHEBI:22671 + CHEBI:23907 + atom chebi_ontology - AcOH - CH3-COOH - CH3CO2H - E 260 - E-260 - E260 - Essigsaeure - Ethanoic acid - Ethylic acid - HOAc - INS No. 260 - MeCO2H - MeCOOH - Methanecarboxylic acid - acide acetique - ethoic acid - CHEBI:15366 + atome + atomo + atoms + atomus + element + elements + CHEBI:33250 - acetic acid + atom - - - Beilstein:506007 - Beilstein - - - - - CAS:64-19-7 - ChemIDplus - - - - - CAS:64-19-7 - KEGG COMPOUND - - - - - CAS:64-19-7 - NIST Chemistry WebBook - - - - - Drug_Central:4211 - DrugCentral - - - - - Gmelin:1380 - Gmelin - - - - - LIPID_MAPS_instance:LMFA01010002 - LIPID MAPS - - - - - PMID:12005138 - Europe PMC - - - - - PMID:15107950 - Europe PMC - - - - - PMID:16630552 - Europe PMC - - - - - PMID:16774200 - Europe PMC - - - - - PMID:17190852 - Europe PMC - - - - - PMID:19416101 - Europe PMC - - - - - PMID:19469536 - Europe PMC - - - - - PMID:22153255 - Europe PMC - - - - - PMID:22173419 - Europe PMC - - - - - Reaxys:506007 - Reaxys - - - - - ACETIC ACID - PDBeChem - - - - - Acetic acid - KEGG_COMPOUND - - - + - acetic acid + atom IUPAC - + - AcOH - ChEBI + atome + IUPAC - + - CH3-COOH + atomo IUPAC - + - CH3CO2H + atoms ChEBI - + - E 260 + atomus ChEBI - + - E-260 + element ChEBI - + - E260 + elements ChEBI + + + + + + + + + + + + + + A nucleus is the positively charged central portion of an atom, excluding the orbital electrons. + nucleus + chebi_ontology + Atomkern + Kern + noyau + noyau atomique + nuclei + nucleo + nucleo atomico + nucleus atomi + CHEBI:33252 + + atomic nucleus + + + + + nucleus + IUPAC + + - + - Essigsaeure + Atomkern ChEBI - + - Ethanoic acid - KEGG_COMPOUND + Kern + ChEBI - + - Ethylic acid - ChemIDplus + noyau + IUPAC - + - HOAc + noyau atomique ChEBI - + - INS No. 260 + nuclei ChEBI - + + + nucleo + IUPAC + + + - MeCO2H + nucleo atomico ChEBI - + - MeCOOH + nucleus atomi ChEBI + + + + + + + + + Heavy nuclear particle: proton or neutron. + nucleon + chebi_ontology + Nukleon + Nukleonen + nucleons + CHEBI:33253 + + nucleon + + + + + nucleon + IUPAC + + + + + nucleon + IUPAC + + - + - Methanecarboxylic acid - ChemIDplus + Nukleon + ChEBI - + - acide acetique - ChemIDplus + Nukleonen + ChEBI - + - ethoic acid + nucleons ChEBI - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 0 - O2 - InChI=1S/O2/c1-2 - MYMOFIZGZYHOMD-UHFFFAOYSA-N - 31.998 - 31.98983 - O=O - CHEBI:10745 - CHEBI:13416 - CHEBI:23833 - CHEBI:25366 - CHEBI:30491 - CHEBI:44742 - CHEBI:7860 - CAS:7782-44-7 - Gmelin:485 - HMDB:HMDB0001377 - KEGG:C00007 - KEGG:D00003 - MetaCyc:OXYGEN-MOLECULE - MolBase:750 - PDBeChem:OXY - PMID:10906528 - PMID:16977326 - PMID:18210929 - PMID:18638417 - PMID:19840863 - PMID:7710549 - PMID:9463773 - Wikipedia:Oxygen - dioxygen - chebi_ontology - Disauerstoff - E 948 - E-948 - E948 - O2 - OXYGEN MOLECULE - Oxygen - [OO] - dioxygene - molecular oxygen - CHEBI:15379 - - dioxygen + + + primary amide - - - - CAS:7782-44-7 - ChemIDplus - - - - - CAS:7782-44-7 - KEGG COMPOUND - - - - - CAS:7782-44-7 - NIST Chemistry WebBook - - - - - Gmelin:485 - Gmelin - - - - - PMID:10906528 - Europe PMC - - - - - PMID:16977326 - Europe PMC - - - - - PMID:18210929 - Europe PMC - - - - - PMID:18638417 - Europe PMC - - - - - PMID:19840863 - Europe PMC - - - - - PMID:7710549 - Europe PMC - - - - - PMID:9463773 - Europe PMC - - - - - dioxygen - IUPAC - - - - - - Disauerstoff - ChEBI - - - - - E 948 - ChEBI - - - - - E-948 - ChEBI - - - - - E948 - ChEBI - - - - - O2 - IUPAC - - - - - O2 - KEGG_COMPOUND - - - - - O2 - UniProt - - - - - OXYGEN MOLECULE - PDBeChem - - - - - Oxygen - KEGG_COMPOUND - - - - - [OO] - MolBase - - - - - dioxygene - ChEBI - - - - - molecular oxygen - ChEBI - - + - - - Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n >= 2) and their intramolecular hemiacetals. - 0 - C2H4O2(CH2O)n - CHEBI:13755 - CHEBI:22305 - CHEBI:2561 - KEGG:C01370 - Wikipedia:Aldose - Aldose - chebi_ontology - aldoses - an aldose - CHEBI:15693 - - aldose + + + elemental molecular entity - - - - Aldose - KEGG_COMPOUND - - - - - aldoses - ChEBI - - - - - an aldose - UniProt - - + - - - - A peptide containing ten or more amino acid residues. - C4H6N2O3R2(C2H2NOR)n - CHEBI:14860 - CHEBI:8314 - KEGG:C00403 - Polypeptide - polypeptides + + + A nutrient is a food component that an organism uses to survive and grow. chebi_ontology - Polypeptid - polipeptido - CHEBI:15841 + nutrients + CHEBI:33284 - polypeptide + nutrient - - - Polypeptide - KEGG_COMPOUND - - - - - polypeptides - IUPAC - - - - - - Polypeptid - ChEBI - - - + - polipeptido + nutrients ChEBI - + - - - + + + heteroorganic entity + + + + + + + + - + - A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues. - 0 - (C5H8O6PR)n.C10H17O10PR2 - CHEBI:13672 - CHEBI:14859 - CHEBI:8312 - KEGG:C00419 - Polynucleotide - chebi_ontology - polynucleotides - CHEBI:15986 - - polynucleotide + alkali metal molecular entity - - - - Polynucleotide - KEGG_COMPOUND - - - - - polynucleotides - ChEBI - - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms. - 0 - H3N - InChI=1S/H3N/h1H3 - QGZKDVFQNNGYKY-UHFFFAOYSA-N - 17.03056 - 17.02655 - [H]N([H])[H] - CHEBI:13405 - CHEBI:13406 - CHEBI:13407 - CHEBI:13771 - CHEBI:22533 - CHEBI:44269 - CHEBI:44284 - CHEBI:44404 - CHEBI:7434 - Beilstein:3587154 - CAS:7664-41-7 - Drug_Central:4625 - Gmelin:79 - HMDB:HMDB0000051 - KEGG:C00014 - KEGG:D02916 - KNApSAcK:C00007267 - MetaCyc:AMMONIA - MolBase:930 - PDBeChem:NH3 - PMID:110589 - PMID:11139349 - PMID:11540049 - PMID:11746427 - PMID:11783653 - PMID:13753780 - PMID:14663195 - PMID:15092448 - PMID:15094021 - PMID:15554424 - PMID:15969015 - PMID:16008360 - PMID:16050680 - PMID:16348008 - PMID:16349403 - PMID:16614889 - PMID:16664306 - PMID:16842901 - PMID:17025297 - PMID:17439666 - PMID:17569513 - PMID:17737668 - PMID:18670398 - PMID:22002069 - PMID:22081570 - PMID:22088435 - PMID:22100291 - PMID:22130175 - PMID:22150211 - PMID:22240068 - PMID:22290316 - PMID:22342082 - PMID:22385337 - PMID:22443779 - PMID:22560242 - Reaxys:3587154 - Wikipedia:Ammonia - AMMONIA - Ammonia - ammonia - azane - chebi_ontology - Ammoniak - NH3 - R-717 - [NH3] - ammoniac - amoniaco - spirit of hartshorn - CHEBI:16134 - - ammonia + + + pnictogen - - - - Beilstein:3587154 - Beilstein - - - - - CAS:7664-41-7 - ChemIDplus - - - - - CAS:7664-41-7 - KEGG COMPOUND - - - - - CAS:7664-41-7 - NIST Chemistry WebBook - - - - - Drug_Central:4625 - DrugCentral - - - - - Gmelin:79 - Gmelin - - - - - PMID:110589 - Europe PMC - - - - - PMID:11139349 - Europe PMC - - - - - PMID:11540049 - Europe PMC - - - - - PMID:11746427 - Europe PMC - - - - - PMID:11783653 - Europe PMC - - - - - PMID:13753780 - Europe PMC - - - - - PMID:14663195 - Europe PMC - - - - - PMID:15092448 - Europe PMC - - - - - PMID:15094021 - Europe PMC - - - - - PMID:15554424 - Europe PMC - - - - - PMID:15969015 - Europe PMC - - - - - PMID:16008360 - Europe PMC - - - - - PMID:16050680 - Europe PMC - - - - - PMID:16348008 - Europe PMC - - - - - PMID:16349403 - Europe PMC - - - - - PMID:16614889 - Europe PMC - - - - - PMID:16664306 - Europe PMC - - - - - PMID:16842901 - Europe PMC - - - - - PMID:17025297 - Europe PMC - - - - - PMID:17439666 - Europe PMC - - - - - PMID:17569513 - Europe PMC - - - - - PMID:17737668 - Europe PMC - - - - - PMID:18670398 - Europe PMC - - - - - PMID:22002069 - Europe PMC - - - - - PMID:22081570 - Europe PMC - - - - - PMID:22088435 - Europe PMC - - - - - PMID:22100291 - Europe PMC - - - - - PMID:22130175 - Europe PMC - - - - - PMID:22150211 - Europe PMC - - - - - PMID:22240068 - Europe PMC - - - - - PMID:22290316 - Europe PMC - - - - - PMID:22342082 - Europe PMC - - - - - PMID:22385337 - Europe PMC - - - - - PMID:22443779 - Europe PMC - - - - - PMID:22560242 - Europe PMC - - - - - Reaxys:3587154 - Reaxys - - - - - AMMONIA - PDBeChem - - - - - Ammonia - KEGG_COMPOUND - - - - - ammonia - IUPAC - - - - - - azane - IUPAC - - - - - - Ammoniak - ChemIDplus - - - - - NH3 - IUPAC - - - - - NH3 - KEGG_COMPOUND - - - - - NH3 - UniProt - - - - - R-717 - ChEBI - - - - - [NH3] - MolBase - - - - - ammoniac - ChEBI - - - - - amoniaco - ChEBI - - - - - spirit of hartshorn - ChemIDplus - - + - - - - - - - - - - - + + - - + + - - - - - - - - - - - - - A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid. - -2 - O4S - InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 - QAOWNCQODCNURD-UHFFFAOYSA-L - 96.06360 - 95.95283 - [O-]S([O-])(=O)=O - CHEBI:15135 - CHEBI:45687 - CHEBI:9335 - Beilstein:3648446 - CAS:14808-79-8 - Gmelin:2120 - HMDB:HMDB0001448 - KEGG:C00059 - KEGG:D05963 - MetaCyc:SULFATE - PDBeChem:SO4 - PMID:11200094 - PMID:11452993 - PMID:11581495 - PMID:11798107 - PMID:12166931 - PMID:12668033 - PMID:14597181 - PMID:15093386 - PMID:15984785 - PMID:16186560 - PMID:16345535 - PMID:16347366 - PMID:16348007 - PMID:16483812 - PMID:16534979 - PMID:16656509 - PMID:16742508 - PMID:16742518 - PMID:17120760 - PMID:17420092 - PMID:17439666 - PMID:17709180 - PMID:18398178 - PMID:18815700 - PMID:18846414 - PMID:19047345 - PMID:19244483 - PMID:19544990 - PMID:19628332 - PMID:19812358 - PMID:30398859 - Reaxys:3648446 - Wikipedia:Sulfate - Sulfate - sulfate - tetraoxidosulfate(2-) - tetraoxosulfate(2-) - tetraoxosulfate(VI) + pnictogen molecular entity + + + + + + + + + Any p-block element belonging to the group 16 family of the periodic table. + PMID:17084588 + chalcogen + chalcogens chebi_ontology - SO4(2-) - SULFATE ION - Sulfate anion(2-) - Sulfate dianion - Sulfate(2-) - Sulfuric acid ion(2-) - [SO4](2-) - sulphate - sulphate ion - CHEBI:16189 + Chalkogen + Chalkogene + anfigeno + anfigenos + calcogeno + calcogenos + chalcogene + chalcogenes + group 16 elements + group VI elements + CHEBI:33303 - sulfate + chalcogen - - - Beilstein:3648446 - Beilstein - - - - - CAS:14808-79-8 - ChemIDplus - - - - - CAS:14808-79-8 - NIST Chemistry WebBook - - - - - Gmelin:2120 - Gmelin - - - - - PMID:11200094 - Europe PMC - - - - - PMID:11452993 - Europe PMC - - - - - PMID:11581495 - Europe PMC - - - - - PMID:11798107 - Europe PMC - - - - - PMID:12166931 - Europe PMC - - - - - PMID:12668033 - Europe PMC - - - - - PMID:14597181 - Europe PMC - - - - - PMID:15093386 - Europe PMC - - - - - PMID:15984785 - Europe PMC - - - - - PMID:16186560 - Europe PMC - - - - - PMID:16345535 - Europe PMC - - - - - PMID:16347366 - Europe PMC - - - - - PMID:16348007 - Europe PMC - - - - - PMID:16483812 - Europe PMC - - - - - PMID:16534979 - Europe PMC - - - - - PMID:16656509 - Europe PMC - - - - - PMID:16742508 - Europe PMC - - - - - PMID:16742518 - Europe PMC - - - - - PMID:17120760 - Europe PMC - - - - - PMID:17420092 - Europe PMC - - - - - PMID:17439666 - Europe PMC - - - - - PMID:17709180 - Europe PMC - - - - - PMID:18398178 - Europe PMC - - - - - PMID:18815700 - Europe PMC - - - - - PMID:18846414 - Europe PMC - - - - - PMID:19047345 - Europe PMC - - - - - PMID:19244483 - Europe PMC - - - - - PMID:19544990 - Europe PMC - - - - - PMID:19628332 - Europe PMC - - - - - PMID:19812358 - Europe PMC - - - - - PMID:30398859 - Europe PMC - - - + - Reaxys:3648446 - Reaxys - - - - - Sulfate - KEGG_COMPOUND - - - - - sulfate - IUPAC - - - - - - sulfate - UniProt - - - - - tetraoxidosulfate(2-) - IUPAC - + PMID:17084588 + Europe PMC - + - tetraoxosulfate(2-) + chalcogen IUPAC - + - tetraoxosulfate(VI) + chalcogens IUPAC - - - SO4(2-) - IUPAC - - - - - SULFATE ION - PDBeChem - - - - - Sulfate anion(2-) - HMDB - - - - - Sulfate dianion - HMDB - - - - - Sulfate(2-) - HMDB - - - + - Sulfuric acid ion(2-) - HMDB + Chalkogen + ChEBI - + - [SO4](2-) - IUPAC + Chalkogene + ChEBI - + - sulphate + anfigeno ChEBI - + - sulphate ion + anfigenos ChEBI - - - - - - - - - - - - - - - - - - - - - - A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells. - 0 - (C14H21NO12)n - CHEBI:14412 - CHEBI:24622 - CHEBI:24623 - CHEBI:5772 - Beilstein:8538277 - CAS:9004-61-9 - HMDB:HMDB0010366 - KEGG:C00518 - KEGG:D08043 - KEGG:G10505 - PMID:11122186 - PMID:18056362 - PMID:18290544 - Reaxys:8187837 - Wikipedia:Hyaluronan - Hyaluronic acid - chebi_ontology - Hyaluronsaeure - [beta-D-glucopyranuronosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->4)]n - [beta-N-Acetyl-D-glucosaminyl(1,4)beta-D-glucuronosyl(1,3)]n - acide hyaluronique - acido hialuronico - hyaluronan - CHEBI:16336 - - hyaluronic acid - - - - - Beilstein:8538277 - Beilstein - - - - - CAS:9004-61-9 - ChemIDplus - - - - - CAS:9004-61-9 - KEGG COMPOUND - - - - PMID:11122186 - Europe PMC - - - - - PMID:18056362 - Europe PMC - - - - - PMID:18290544 - Europe PMC - - - - - Reaxys:8187837 - Reaxys - - - - - Hyaluronic acid - KEGG_COMPOUND - - - + - Hyaluronsaeure + calcogeno ChEBI - + - [beta-D-glucopyranuronosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->4)]n + calcogenos ChEBI - + - [beta-N-Acetyl-D-glucosaminyl(1,4)beta-D-glucuronosyl(1,3)]n - KEGG_COMPOUND + chalcogene + ChEBI - + - acide hyaluronique + chalcogenes ChEBI - + - acido hialuronico + group 16 elements ChEBI - + - hyaluronan + group VI elements ChEBI - + - - + + - + - A naturally occurring polypeptide synthesized at the ribosome. - CHEBI:8526 - KEGG:C00017 - chebi_ontology - Protein - a protein - polypeptide chain - protein polypeptide chains - CHEBI:16541 - - protein polypeptide chain + chalcogen molecular entity - - - - Protein - KEGG_COMPOUND - - - - - a protein - UniProt - - - - - polypeptide chain - ChEBI - - - - - protein polypeptide chains - ChEBI - - + - - - Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates. - CHEBI:15131 - CHEBI:23008 - CHEBI:9318 - Wikipedia:Carbohydrate - carbohydrate - carbohydrates + + + carbon group element atom + + + + + + + + + An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table. + main group elements chebi_ontology - Kohlenhydrat - Kohlenhydrate - a carbohydrate - carbohidrato - carbohidratos - glucide - glucides - glucido - glucidos - hydrates de carbone - saccharide - saccharides - saccharidum - CHEBI:16646 + Hauptgruppenelement + Hauptgruppenelemente + main group element + CHEBI:33318 - carbohydrate + main group element atom - - - carbohydrate - IUPAC - - - - + - carbohydrates + main group elements IUPAC - - - Kohlenhydrat - ChEBI - - - - - Kohlenhydrate - ChEBI - - - - - a carbohydrate - UniProt - - - - - carbohidrato - IUPAC - - - - - carbohidratos - IUPAC - - - - - glucide - ChEBI - - - + - glucides + Hauptgruppenelement ChEBI - + - glucido + Hauptgruppenelemente ChEBI - + - glucidos + main group element ChEBI + + + + + + + + + sulfur oxoacid derivative + + + + + + + + + alkali metal cation + + + + + + + + + metal atom + + + + + + + + + s-block element atom + + + + + + + + + Any main group element atom belonging to the p-block of the periodic table. + chebi_ontology + p-block element + p-block elements + CHEBI:33560 + + p-block element atom + - + - hydrates de carbone + p-block element ChEBI - - - saccharide - IUPAC - - - - - saccharides - IUPAC - - - + - saccharidum + p-block elements ChEBI - + - - - + + + + - + + carboxylic acid + + + + + + + + - - + + - Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc. - 0 - (C2H2NOR)nC2H3NOR - CHEBI:14753 - CHEBI:25906 - CHEBI:7990 - KEGG:C00012 - Peptide - peptides - chebi_ontology - Peptid - peptido - peptidos - CHEBI:16670 - - peptide + main group molecular entity - - - - Peptide - KEGG_COMPOUND - - - - - peptides - IUPAC - - - - - - Peptid - ChEBI - - - - - peptido - ChEBI - - - - - peptidos - ChEBI - - + - - - + + - - + + - +1 - C8H12NO3 - InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/p+1 - SFLSHLFXELFNJZ-UHFFFAOYSA-O - 170.187 - 170.08117 - C1=CC(=CC(=C1O)O)C(C[NH3+])O - chebi_ontology - noradrenaline - CHEBI:166902 - - noradrenaline(1+) + carbon group molecular entity - - - - noradrenaline - UniProt - - + - - - Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001. - chebi_ontology - glycans - CHEBI:167559 - - glycan + + + cyclic compound - - - - glycans - ChEBI - - + - - - - - - - - - - - - - - - - - - - - - - - + + - - + + - An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position. - 0 - C10H12N2 - InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2 - APJYDQYYACXCRM-UHFFFAOYSA-N - 160.21570 - 160.10005 - NCCc1c[nH]c2ccccc12 - CHEBI:15274 - CHEBI:27161 - CHEBI:46157 - CHEBI:9767 - Beilstein:125513 - CAS:61-54-1 - DrugBank:DB08653 - Gmelin:603448 - HMDB:HMDB0000303 - KEGG:C00398 - KNApSAcK:C00001434 - MetaCyc:TRYPTAMINE - PDBeChem:TSS - PMID:16126914 - PMID:22770225 - PMID:24345948 - PMID:24558969 - Reaxys:125513 - Wikipedia:Tryptamine - 2-(1H-indol-3-yl)ethanamine - Tryptamine - chebi_ontology - 1H-indole-3-ethanamine - 2-(1H-INDOL-3-YL)ETHANAMINE - 2-(3-indolyl)ethylamine - 3-(2-Aminoethyl)indole - CHEBI:16765 - - tryptamine + hydrogen molecular entity - - - - Beilstein:125513 - Beilstein - - - - - CAS:61-54-1 - ChemIDplus - - - - - CAS:61-54-1 - KEGG COMPOUND - - - - - CAS:61-54-1 - NIST Chemistry WebBook - - - - - Gmelin:603448 - Gmelin - - - - - PMID:16126914 - Europe PMC - - - - - PMID:22770225 - Europe PMC - - - - - PMID:24345948 - Europe PMC - - - - - PMID:24558969 - Europe PMC - - - - - Reaxys:125513 - Reaxys - - - - - 2-(1H-indol-3-yl)ethanamine - IUPAC - - - - - - Tryptamine - KEGG_COMPOUND - - - - - 1H-indole-3-ethanamine - NIST_Chemistry_WebBook - - - - - 2-(1H-INDOL-3-YL)ETHANAMINE - PDBeChem - - - - - 2-(3-indolyl)ethylamine - ChemIDplus - - - - - 3-(2-Aminoethyl)indole - KEGG_COMPOUND - - + - - - + + + polycyclic compound + + + + + + + + + aromatic compound + + + + + + + + + + organic aromatic compound + + + + + + + + - - - - - - - + + s-block molecular entity + + + + + + + + - - + + - - - - - - - - - - - - - A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin. - 0 - C33H36N4O6 - InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14- - BPYKTIZUTYGOLE-IFADSCNNSA-N - 584.673 - 584.26348 - CC1=C(C=C)\C(NC1=O)=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(CCC(O)=O)C(C)=C(N2)\C=C2/NC(=O)C(C=C)=C2C)N1 - CHEBI:13898 - CHEBI:22870 - CHEBI:3099 - Beilstein:74376 - CAS:635-65-4 - Gmelin:411033 - HMDB:HMDB0000054 - KEGG:C00486 - KNApSAcK:C00029828 - MetaCyc:BILIRUBIN - PDBeChem:BLR - PMID:12799017 - PMID:18442622 - PMID:23763371 - PMID:23768684 - PMID:30224965 - PMID:8605219 - PMID:9587403 - Reaxys:74376 - Wikipedia:Bilirubin - 3,18-diethenyl-2,7,13,17-tetramethyl-1,19-dioxo-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid - bilirubin - chebi_ontology - 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic acid - 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid - 2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid - 8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbiladiene-ac-1,19(21H,24H)-dione - Bilirubin - bilirubin(Z,Z) - bilirubin-IXalpha - CHEBI:16990 - - bilirubin IXalpha + p-block molecular entity - - - - Beilstein:74376 - Beilstein - - - - - CAS:635-65-4 - ChemIDplus - - - - - CAS:635-65-4 - KEGG COMPOUND - - - - - Gmelin:411033 - Gmelin - - - - - PMID:12799017 - Europe PMC - - - - - PMID:18442622 - Europe PMC - - - - - PMID:23763371 - Europe PMC - - - - - PMID:23768684 - Europe PMC - - - - - PMID:30224965 - Europe PMC - - - - - PMID:8605219 - Europe PMC - - - - - PMID:9587403 - Europe PMC - - - - - Reaxys:74376 - Reaxys - - - - - 3,18-diethenyl-2,7,13,17-tetramethyl-1,19-dioxo-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid - IUPAC - - - - - - bilirubin - IUPAC - - - - - - 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic acid - ChemIDplus - - - - - 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid - ChemIDplus - - - - - 2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid - IUPAC - - - - - 8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbiladiene-ac-1,19(21H,24H)-dione - JCBN - - - - - Bilirubin - KEGG_COMPOUND - - - - - bilirubin(Z,Z) - ChEBI - - - - - bilirubin-IXalpha - ChEBI - - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms. - CHEBI:13302 - CHEBI:21123 - CHEBI:33698 - CHEBI:4291 - CAS:9007-49-2 - KEGG:C00039 - Deoxyribonucleic acid - deoxyribonucleic acids - chebi_ontology - (Deoxyribonucleotide)m - (Deoxyribonucleotide)n - (Deoxyribonucleotide)n+m - DNA - DNAn - DNAn+1 - DNS - Desoxyribonukleinsaeure - deoxyribonucleic acids - desoxyribose nucleic acid - thymus nucleic acid - CHEBI:16991 - - deoxyribonucleic acid + + + + biomacromolecule - - - - CAS:9007-49-2 - ChemIDplus - - - - - CAS:9007-49-2 - KEGG COMPOUND - - - - - Deoxyribonucleic acid - KEGG_COMPOUND - - - - - deoxyribonucleic acids - IUPAC - - - - - - (Deoxyribonucleotide)m - KEGG_COMPOUND - - - - - (Deoxyribonucleotide)n - KEGG_COMPOUND - - - - - (Deoxyribonucleotide)n+m - KEGG_COMPOUND - - - - - DNA - IUPAC - - - - - DNA - KEGG_COMPOUND - - - - - DNA - UniProt - - - - - DNAn - KEGG_COMPOUND - - - - - DNAn+1 - KEGG_COMPOUND - - - - - DNS - ChEBI - - - - - Desoxyribonukleinsaeure - ChEBI - - - - - deoxyribonucleic acids - ChEBI - - - - - desoxyribose nucleic acid - ChemIDplus - - - - - thymus nucleic acid - ChEBI - - + - - - A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H). - 0 - COR2 - 28.010 - 27.99491 - [*]C([*])=O - CHEBI:13427 - CHEBI:13646 - CHEBI:24974 - CHEBI:6127 - CHEBI:8742 - KEGG:C01450 - Wikipedia:Ketone - Ketone - ketones - chebi_ontology - Keton - R-CO-R' - a ketone - cetone - ketones - CHEBI:17087 - - ketone + + + information biomacromolecule - - - - Ketone - KEGG_COMPOUND - - - - - ketones - IUPAC - - - - - - Keton - ChEBI - - - - - R-CO-R' - KEGG_COMPOUND - - - - - a ketone - UniProt - - - - - cetone - ChEBI - - - - - ketones - ChEBI - - + - - - - A compound in which a carbohydrate component is covalently bound to a protein component. - CHEBI:14349 - CHEBI:5481 - CHEBI:5493 - KEGG:C00326 - Glycoprotein - glycoproteins - chebi_ontology - Glykoprotein - Glykoproteine - a glycoprotein - glicoproteina - glicoproteinas - glycoproteine - glycoproteines - CHEBI:17089 - - glycoprotein + + + proteinogenic amino-acid residue - - - - Glycoprotein - KEGG_COMPOUND - - - - - glycoproteins - IUPAC - - - - - - Glykoprotein - ChEBI - - - - - Glykoproteine - ChEBI - - - - - a glycoprotein - UniProt - - - - - glicoproteina - ChEBI - - - - - glicoproteinas - ChEBI - - - - - glycoproteine - ChEBI - - - - - glycoproteines - ChEBI - - + - - - - - - - - - - An aldohexose used as a source of energy and metabolic intermediate. - 0 - C6H12O6 - 180.15588 - 180.06339 - CHEBI:14313 - CHEBI:24277 - CHEBI:33929 - CHEBI:5418 - CAS:50-99-7 - KEGG:C00293 - Wikipedia:Glucose - Glucose - gluco-hexose - glucose + + + When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue. + amino acid residue + protein residue chebi_ontology - DL-glucose - Glc - Glukose - CHEBI:17234 - - glucose + CHEBI:33708 + amino-acid residue - - - CAS:50-99-7 - KEGG COMPOUND - - - - - Glucose - KEGG_COMPOUND - - - - - gluco-hexose - IUPAC - - - - - - glucose - IUPAC - - - - - - DL-glucose - ChEBI - - - - - Glc - JCBN + + + When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue. + Dummy:dummy - - - Glukose - ChEBI + + + protein residue + PRO:DAN - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The carbon oxoanion resulting from the removal of a proton from carbonic acid. - -1 - CHO3 - InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1 - BVKZGUZCCUSVTD-UHFFFAOYSA-M - 61.01684 - 60.99312 - OC([O-])=O - CHEBI:13363 - CHEBI:22863 - CHEBI:40961 - CHEBI:5589 - Beilstein:3903504 - CAS:71-52-3 - Gmelin:49249 - HMDB:HMDB0000595 - KEGG:C00288 - MetaCyc:HCO3 - PDBeChem:BCT - PMID:17215880 - PMID:17505962 - PMID:18439416 - PMID:28732801 - PMID:29150416 - PMID:29460248 - PMID:29466234 - PMID:4208463 - Wikipedia:Bicarbonate - Hydrogencarbonate - hydrogen(trioxidocarbonate)(1-) - hydrogencarbonate - hydrogencarbonate(1-) - hydrogentrioxocarbonate(1-) - hydrogentrioxocarbonate(IV) - hydroxidodioxidocarbonate(1-) - chebi_ontology - Acid carbonate - BICARBONATE ION - Bicarbonate - HCO3(-) - HCO3- - [CO2(OH)](-) - hydrogen carbonate - CHEBI:17544 - - hydrogencarbonate + + + alpha-amino-acid residue - - - - Beilstein:3903504 - Beilstein - - - - - CAS:71-52-3 - ChemIDplus - - - - - Gmelin:49249 - Gmelin - - - - - PMID:17215880 - Europe PMC - - - - - PMID:17505962 - Europe PMC - - - - - PMID:18439416 - Europe PMC - - - - - PMID:28732801 - Europe PMC - - - - - PMID:29150416 - Europe PMC - - - - - PMID:29460248 - Europe PMC - - - - - PMID:29466234 - Europe PMC - - - - - PMID:4208463 - Europe PMC - - - - - Hydrogencarbonate - KEGG_COMPOUND - - - - - hydrogen(trioxidocarbonate)(1-) - IUPAC - - - - - - hydrogencarbonate - IUPAC - - - - - - hydrogencarbonate - UniProt - - - - - hydrogencarbonate(1-) - IUPAC - - - - - - hydrogentrioxocarbonate(1-) - IUPAC - - - - - - hydrogentrioxocarbonate(IV) - IUPAC - - - - - - hydroxidodioxidocarbonate(1-) - IUPAC - - - - - - Acid carbonate - KEGG_COMPOUND - - - - - BICARBONATE ION - PDBeChem - - - - - Bicarbonate - KEGG_COMPOUND - - - - - HCO3(-) - IUPAC - - - - - HCO3- - KEGG_COMPOUND - - - - - [CO2(OH)](-) - IUPAC - - - - - hydrogen carbonate - PDBeChem - - + - - - A molecular entity that can transfer ("donate") an electron, a pair of electrons, an atom or a group to another molecular entity. - CHEBI:14202 - CHEBI:4697 - KEGG:C01351 - Donor - chebi_ontology - Donator - donneur - CHEBI:17891 - - donor + + + + organic cyclic compound - - - - Donor - KEGG_COMPOUND - - - - - Donator - ChEBI - - - - - donneur - ChEBI - - + - - - 'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids. - CHEBI:14517 - CHEBI:25054 - CHEBI:6486 - KEGG:C01356 - Lipid - lipids - chebi_ontology - CHEBI:18059 - - lipid + + + + heteroarene - - - - Lipid - KEGG_COMPOUND - - - - - lipids - IUPAC - - - + - - - Any polysaccharide containing a substantial proportion of aminomonosaccharide residues. - CHEBI:14361 - CHEBI:24398 - CHEBI:5495 - KEGG:C02545 - Wikipedia:Glycosaminoglycan - Glycosaminoglycan - glycosaminoglycan - chebi_ontology - Glykosaminoglykan - glicosaminoglicano - glycosaminoglycane - glycosaminoglycans - CHEBI:18085 - - glycosaminoglycan + + + + conjugated protein - - - - Glycosaminoglycan - KEGG_COMPOUND - - - - - glycosaminoglycan - IUPAC - - - - - - Glykosaminoglykan - ChEBI - - - - - glicosaminoglicano - IUPAC - - - - - glycosaminoglycane - IUPAC - - - - - glycosaminoglycans - ChEBI - - + - - - Any six-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldohexose) or a ketone group at position 2 (ketohexose). - CHEBI:14399 - CHEBI:24590 - CHEBI:5709 - GlyGen:G70994MS - GlyTouCan:G70994MS - KEGG:C00738 - Hexose - chebi_ontology - WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/ - hexoses - CHEBI:18133 - - hexose + + + macromolecule - - - - Hexose - KEGG_COMPOUND - - - - - WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/ - GlyTouCan - - - - - hexoses - ChEBI - - + - - - - - A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues. - CHEBI:14864 - CHEBI:26205 - CHEBI:8322 - KEGG:C00420 - Polysaccharide - polysaccharides + + chebi_ontology - Glycan - Glycane - Glykan - Glykane - glycans - polisacarido - polisacaridos - CHEBI:18154 - - polysaccharide + CHEBI:33937 + + macronutrient - - - - Polysaccharide - KEGG_COMPOUND - - - - - polysaccharides - IUPAC - - - - - - Glycan - KEGG_COMPOUND - - - - - Glycane - ChEBI - - - - - Glykan - ChEBI - - - - - Glykane - ChEBI - - - - - glycans - IUPAC - - - - - polisacarido - ChEBI - - - - - polisacaridos - IUPAC - - + - - - That part of DNA or RNA that may be involved in pairing. - CHEBI:13873 - CHEBI:25598 - CHEBI:2995 - KEGG:C00701 - Wikipedia:Nucleobase - chebi_ontology - Base - nucleobases - CHEBI:18282 - - nucleobase + + + + steroid - - - - Base - KEGG_COMPOUND - - - - - nucleobases - ChEBI - - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The R-enantiomer of noradrenaline. - 0 - C8H11NO3 - InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1 - SFLSHLFXELFNJZ-QMMMGPOBSA-N - 169.17780 - 169.07389 - NC[C@H](O)c1ccc(O)c(O)c1 - CHEBI:1 - CHEBI:14668 - CHEBI:25592 - CHEBI:258884 - CHEBI:43725 - Beilstein:2804840 - Beilstein:4231961 - CAS:51-41-2 - DrugBank:DB00368 - Drug_Central:1960 - HMDB:HMDB0000216 - KEGG:C00547 - KEGG:D00076 - KNApSAcK:C00001424 - PDBeChem:LNR - Reaxys:2804840 - Wikipedia:Norepinephrine - 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol - chebi_ontology - (-)-arterenol - (-)-noradrenaline - (-)-norepinephrine - (R)-(-)-norepinephrine - (R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol - (R)-norepinephrine - 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol - Arterenol - L-NOREPINEPHRINE - L-Noradrenaline - Noradrenaline - Norepinephrine - norepinefrina - norepinephrine - norepinephrinum - CHEBI:18357 - - (R)-noradrenaline + + + + organonitrogen compound - - - - Beilstein:2804840 - Beilstein - - - - - Beilstein:4231961 - ChemIDplus - - - - - CAS:51-41-2 - ChemIDplus - - - - - CAS:51-41-2 - KEGG COMPOUND - - - - - Drug_Central:1960 - DrugCentral - - - - - Reaxys:2804840 - Reaxys - - - - - 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol - IUPAC - - - - - - (-)-arterenol - ChemIDplus - - - - - (-)-noradrenaline - IUPHAR - - - - - (-)-norepinephrine - ChemIDplus - - - - - (R)-(-)-norepinephrine - ChemIDplus - - - - - (R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol - ChemIDplus - - - - - (R)-norepinephrine - ChemIDplus - - - - - 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol - KEGG_COMPOUND - - - - - Arterenol - KEGG_COMPOUND - - - - - L-NOREPINEPHRINE - PDBeChem - - - - - L-Noradrenaline - KEGG_COMPOUND - - - - - Noradrenaline - KEGG_COMPOUND - - - - - Norepinephrine - KEGG_COMPOUND - - - - - norepinefrina - ChEBI - - - - - - norepinephrine - ChemIDplus - - - - - - norepinephrine - WHO_MedNet - - - - - - norepinephrinum - ChEBI - - - + - - - - - - - - - - A phosphate ion that is the conjugate base of hydrogenphosphate. - -3 - O4P - InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3 - NBIIXXVUZAFLBC-UHFFFAOYSA-K - 94.97136 - 94.95507 - [O-]P([O-])([O-])=O - CHEBI:14791 - CHEBI:45024 - CHEBI:7793 - Beilstein:3903772 - CAS:14265-44-2 - Gmelin:1997 - KEGG:C00009 - PDBeChem:PO4 - Reaxys:3903772 - phosphate - tetraoxidophosphate(3-) - tetraoxophosphate(3-) - tetraoxophosphate(V) - chebi_ontology - Orthophosphate - PHOSPHATE ION - PO4(3-) - Phosphate - [PO4](3-) - CHEBI:18367 - - phosphate(3-) + + + + alkali metal salt - - - - Beilstein:3903772 - Beilstein - - - - - CAS:14265-44-2 - ChemIDplus - - - - - CAS:14265-44-2 - KEGG COMPOUND - - - - - Gmelin:1997 - Gmelin - - - - - PDBeChem:PO4 - ChEBI - - - - - Reaxys:3903772 - Reaxys - - - - - phosphate - IUPAC - - - - - - tetraoxidophosphate(3-) - IUPAC - - - - - - tetraoxophosphate(3-) - IUPAC - - - - - - tetraoxophosphate(V) - IUPAC - - - - - - Orthophosphate - KEGG_COMPOUND - - - - - PHOSPHATE ION - PDBeChem - - - - - PO4(3-) - IUPAC - - - - - Phosphate - KEGG_COMPOUND - - - - - [PO4](3-) - IUPAC - - + - - - 0 - C24H42 - InChI=1S/C24H42/c1-5-8-17(2)20-12-13-21-19-11-10-18-9-6-7-15-23(18,3)22(19)14-16-24(20,21)4/h17-22H,5-16H2,1-4H3/t17-,18+,19+,20-,21+,22+,23+,24-/m1/s1 - QSHQKIURKJITMZ-OBUPQJQESA-N - 330.59028 - 330.32865 - [H][C@@]12CCCC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])CC2)[C@H](C)CCC - Beilstein:2048472 - 5beta-cholane - chebi_ontology - CHEBI:20664 - - 5beta-cholane + + + + carbon oxoacid - - - - Beilstein:2048472 - Beilstein - - - - - 5beta-cholane - IUPAC - - - + - - - An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids. - acyl group - alkanoyl - chebi_ontology - acyl groups - alkanoyl group - groupe acyle - CHEBI:22221 - - acyl group + + + + dicarboxylic acid - - - - acyl group - IUPAC - - - - - alkanoyl - IUPAC - - - - - - acyl groups - ChEBI - - - - - alkanoyl group - ChEBI - - - - - groupe acyle - IUPAC - - + - - - - - alkali metals - chebi_ontology - Alkalimetall - Alkalimetalle - alkali metal - metal alcalin - metal alcalino - metales alcalinos - metaux alcalins - CHEBI:22314 - - alkali metal atom + + + ester - - - - alkali metals - IUPAC - - - - - - Alkalimetall - ChEBI - - - - - Alkalimetalle - ChEBI - - - - - alkali metal - ChEBI - - - - - metal alcalin - ChEBI - - - - - metal alcalino - ChEBI - - - - - metales alcalinos - ChEBI - - - - - metaux alcalins - ChEBI - - + - - - + + + + sulfated glycosaminoglycan + + + + + + + + + + + carbohydrate sulfate + + + + + + + + + cholanoid + + + + + + + + + + - - + + - Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids. - Wikipedia:Alkaloid - Alkaloid - alkaloids + protein + + + + + + + + + + bile acid salt + + + + + + + + + + Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin). chebi_ontology - Alkaloide - alcaloide - alcaloides - CHEBI:22315 + leptons + CHEBI:36338 - alkaloid + lepton - - - Alkaloid - ChEBI - - - - - alkaloids - IUPAC - - - - - - Alkaloide - ChEBI - - - - - alcaloide - ChEBI - - - + - alcaloides + leptons ChEBI - + - - - + + + + Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy). chebi_ontology - aminoglycans - CHEBI:22506 + baryons + CHEBI:36339 - aminoglycan + baryon - + - aminoglycans + baryons ChEBI - + - - - A monoatomic or polyatomic species having one or more elementary charges of the electron. - Anion - anion + + + Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi. + fermion chebi_ontology - Anionen - aniones - anions - CHEBI:22563 + fermions + CHEBI:36340 - anion + fermion - - - Anion - ChEBI - - - + - anion - ChEBI - - - - - anion + fermion IUPAC - - - Anionen - ChEBI - - - + - aniones + fermions ChEBI - - - - anions - IUPAC - - + - - - A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. + + + A particle smaller than an atom. chebi_ontology - antioxidants - antioxydant - antoxidant - CHEBI:22586 + subatomic particles + CHEBI:36342 - antioxidant + subatomic particle - - - antioxidants - ChEBI - - - - - antioxydant - ChEBI - - - + - antoxidant + subatomic particles ChEBI - + - - - A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base). - KEGG:C00701 - Base - base + + + A subatomic particle known to have substructure (i.e. consisting of smaller particles). chebi_ontology - Base1 - Base2 - Basen - Nucleobase - bases - CHEBI:22695 + composite particles + CHEBI:36343 - base + composite particle - - - Base - ChEBI - - - - - base - ChEBI - - - - - base - IUPAC - - - - - - Base1 - KEGG_COMPOUND - - - - - Base2 - KEGG_COMPOUND - - - - - Basen - ChEBI - - - - - Nucleobase - KEGG_COMPOUND - - - + - bases + composite particles ChEBI - + - - - - + + + Hadron is a subatomic particle which experiences the strong force. chebi_ontology - benzopyrroles - CHEBI:22728 + hadrons + CHEBI:36344 - benzopyrrole + hadron - + - benzopyrroles + hadrons ChEBI - + - - - - A sodium salt of the conjugate of any bile acid with either glycine or taurine. - KEGG:C01558 + + + A nucleus or any of its constituents in any of their energy states. + nuclear particle chebi_ontology - Bile acid - bile salts - CHEBI:22868 + CHEBI:36347 - bile salt + nuclear particle - - - Bile acid - KEGG_COMPOUND - - - - - bile salts - ChEBI + + + nuclear particle + IUPAC + - + - - + + - - + + - The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid. - 0 - CH2NO - 44.03272 - 44.01364 - *C(N)=O - PMID:24168430 - carbamoyl - chebi_ontology - -C(O)NH2 - -CONH2 - aminocarbonyl - carbamyl - carbamyl group - carboxamide - CHEBI:23004 - - carbamoyl group + polyatomic entity - - - - PMID:24168430 - Europe PMC - - - - - carbamoyl - IUPAC - - - - - - -C(O)NH2 - ChEBI - - - - - -CONH2 - IUPAC - - - - - aminocarbonyl - IUPAC - - - - - carbamyl - ChEBI - - - - - carbamyl group - ChEBI - - - - - carboxamide - IUPAC - - + - - - 0 - CO - 28.01010 - 27.99491 - O=C(*)* - carbonyl - carbonyl group - chebi_ontology - >C=O - CHEBI:23019 - - carbonyl group + + + + + + + + + + carbonyl compound - - - - carbonyl - IUPAC - - - - - - carbonyl group - ChEBI - - - - - carbonyl group - UniProt - - - - - >C=O - IUPAC - - + - - - An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group). - Wikipedia:Cofactor_(biochemistry) - cofactor - cofactors - chebi_ontology - CHEBI:23357 - - cofactor + + + + + + + + + organic oxo compound - - - - cofactor - IUPAC - - - - - cofactors - IUPAC - - - + - - - Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. - molecular entity - chebi_ontology - entidad molecular - entidades moleculares - entite moleculaire - molecular entities - molekulare Entitaet - CHEBI:23367 - - molecular entity + + + biladienes - - - - molecular entity - IUPAC - - - - - - entidad molecular - IUPAC - - - - - entidades moleculares - IUPAC - - - - - entite moleculaire - IUPAC - - - - - molecular entities - IUPAC - - - - - molekulare Entitaet - ChEBI - - + - - - chebi_ontology - Cyclopeptid - Zyklopeptid - cyclic peptides - peptide cyclique - peptido ciclico - CHEBI:23449 - - cyclic peptide + + + + inorganic ion - - - - Cyclopeptid - ChEBI - - - - - Zyklopeptid - ChEBI - - - - - cyclic peptides - ChEBI - - - - - peptide cyclique - IUPAC - - - - - peptido ciclico - IUPAC - - + - - - Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances. - chebi_ontology - drugs - medicine - CHEBI:23888 - - drug + + + + inorganic cation - - - - drugs - ChEBI - - - - - medicine - ChEBI - - + - - - - chebi_ontology - monoatomic cations - CHEBI:23906 - - monoatomic cation + + + cation - - - - monoatomic cations - ChEBI - - + - - - - A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. - enzyme inhibitor - chebi_ontology - enzyme inhibitors - inhibidor enzimatico - inhibidores enzimaticos - inhibiteur enzymatique - inhibiteurs enzymatiques - CHEBI:23924 - - enzyme inhibitor + + + + organochalcogen compound - - - - enzyme inhibitor - IUPAC - - - - - - enzyme inhibitors - ChEBI - - - - - inhibidor enzimatico - ChEBI - - - - - inhibidores enzimaticos - ChEBI - - - - - inhibiteur enzymatique - ChEBI - - - - - inhibiteurs enzymatiques - ChEBI - - + - - - chebi_ontology - CHEBI:24384 - - glycogens + + + + organooxygen compound - + - - A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. - chemical entity - chebi_ontology - CHEBI:24431 - - chemical entity + + + elemental sodium - - - - chemical entity - UniProt - - + - - - A role played by the molecular entity or part thereof within a biological context. - chebi_ontology - biological function - CHEBI:24432 - - biological role + + + mucopolysaccharide - - - - biological function - ChEBI - - + - - + + + heteroatomic molecular entity + + + + + + + + + + - + - A defined linked collection of atoms or a single atom within a molecular entity. - group - chebi_ontology - Gruppe - Rest - groupe - grupo - grupos - CHEBI:24433 - - group + carboxamide - - - - group - IUPAC - - - - - - Gruppe - ChEBI - - - - - Rest - ChEBI - - - - - groupe - IUPAC - - - - - grupo - IUPAC - - - - - grupos - IUPAC - - + - - - - - A cyclic compound having as ring members atoms of carbon and at least of one other element. - chebi_ontology - organic heterocycle - organic heterocyclic compounds - CHEBI:24532 - - organic heterocyclic compound + + + sulfuric acid derivative - - - - organic heterocycle - ChEBI - - - - - organic heterocyclic compounds - ChEBI - - + - - - A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond. - heterodetic cyclic peptide - chebi_ontology - heterodetic cyclic peptides - peptide cyclique heterodetique - peptido ciclico heterodetico - CHEBI:24533 - - heterodetic cyclic peptide + + + carboacyl group - - - - heterodetic cyclic peptide - IUPAC - - - - - - heterodetic cyclic peptides - ChEBI - - - - - peptide cyclique heterodetique - IUPAC - - - - - peptido ciclico heterodetico - IUPAC - - + - - - - Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds. - chebi_ontology - endocrine - hormones - CHEBI:24621 - - hormone + + + polypyrrole - - - - endocrine - ChEBI - - - - - hormones - ChEBI - - + - - - - - - - - - - - Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)). - chebi_ontology - CHEBI:24651 - - hydroxides + + + + organonitrogen heterocyclic compound - + - - - - - - - - - - Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position. - chebi_ontology - hydroxy-5beta-cholanic acids - CHEBI:24663 - - hydroxy-5beta-cholanic acid + + + + organic sodium salt - - - - hydroxy-5beta-cholanic acids - ChEBI - - + - - - Any compound containing an indole skeleton. - chebi_ontology - CHEBI:24828 - - indoles + + + hydroxy group - + - - - - - - - - - - A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). - oxoacid - oxoacids - chebi_ontology - oxacids - oxiacids - oxo acid - oxy-acids - oxyacids - CHEBI:24833 - - oxoacid + + + oxo group - - - - oxoacid - IUPAC - - - - - - oxoacids - IUPAC - - - - - - oxacids - ChEBI - - - - - oxiacids - ChEBI - - - - - oxo acid - ChEBI - - - - - oxy-acids - ChEBI - - - - - oxyacids - ChEBI - - + - - - - chebi_ontology - inorganic anions - CHEBI:24834 - - inorganic anion + + + carboxy group - - - - inorganic anions - ChEBI - - + - - - A molecular entity that contains no carbon. - chebi_ontology - anorganische Verbindungen - inorganic compounds - inorganic entity - inorganic molecular entities - inorganics - CHEBI:24835 - - inorganic molecular entity + + + + + hydrogen atom - - - - anorganische Verbindungen - ChEBI - - - - - inorganic compounds - ChEBI - - - - - inorganic entity - ChEBI - - - - - inorganic molecular entities - ChEBI - - - - - inorganics - ChEBI - - + - - - + + + A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups. chebi_ontology - inorganic oxides - CHEBI:24836 - - inorganic oxide + CHEBI:50047 + organic amino compound - - - - inorganic oxides - ChEBI - - + - - - - - - - - + + - + - A salt is an assembly of cations and anions. - salt - chebi_ontology - Salz - Salze - ionic compound - ionic compounds - sal - sales - salts - sel - sels - CHEBI:24866 - - salt + organic molecular entity - - - - salt - IUPAC - - - - - - Salz - ChEBI - - - - - Salze - ChEBI - - - - - ionic compound - ChEBI - - - - - ionic compounds - ChEBI - - - - - sal - ChEBI - - - - - sales - ChEBI - - - - - salts - ChEBI - - - - - sel - ChEBI - - - - - sels - ChEBI - - + - - - + + A role is particular behaviour which a material entity may exhibit. chebi_ontology - monoatomic ions - CHEBI:24867 + CHEBI:50906 - monoatomic ion + role - - - - monoatomic ions - ChEBI - - + - - - chebi_ontology - organic salts - organisches Salz - CHEBI:24868 - - organic salt + + + + + + + + + nitrogen molecular entity - - - - organic salts - ChEBI - - - - - organisches Salz - ChEBI - - + - - - A molecular entity having a net electric charge. - Ion - ion - chebi_ontology - Ionen - iones - ions - CHEBI:24870 - - ion + + + organodiyl group - - - - Ion - ChEBI - - - - - ion - ChEBI - - - - - ion - IUPAC - - - - - - Ionen - ChEBI - - - - - iones - ChEBI - - - - - ions - ChEBI - - + - - - chebi_ontology - CHEBI:25046 - - linear tetrapyrrole + + + organic divalent group - + - - - Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. - CHEBI:26619 - CHEBI:35220 - metabolite - chebi_ontology - metabolites - primary metabolites - secondary metabolites - CHEBI:25212 - - metabolite + + + organic univalent group - - - - metabolite - IUPAC - - - - - - metabolites - ChEBI - - - - - primary metabolites - ChEBI - - - - - secondary metabolites - ChEBI - - + - - - - chebi_ontology - a metal cation - metal cations - CHEBI:25213 - - metal cation + + + + organic polycyclic compound - - - - a metal cation - UniProt - - - - - metal cations - ChEBI - - + - - - - A molecule all atoms of which have the same atomic number. + + chebi_ontology - homoatomic molecule - homoatomic molecules - CHEBI:25362 - - elemental molecule + CHEBI:52211 + + physiological role - - - - homoatomic molecule - ChEBI - - - - - homoatomic molecules - ChEBI - - + - - - Any polyatomic entity that is an electrically neutral entity consisting of more than one atom. - molecule - chebi_ontology - Molekuel - molecula - molecules - neutral molecular compounds - CHEBI:25367 - - molecule + + + heterocyclic compound - - - - molecule - IUPAC - - - - - Molekuel - ChEBI - - - - - molecula - IUPAC - - - - - molecules - IUPAC - - - - - neutral molecular compounds - IUPAC - - + - - - - - - - - - A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan. - chebi_ontology - monamines - monoamines - CHEBI:25375 - - monoamine molecular messenger + + + monovalent inorganic cation - - - - monamines - ChEBI - - - - - monoamines - ChEBI - - + - - - - - - - - - An oxoacid containing a single carboxy group. - chebi_ontology - monocarboxylic acids - CHEBI:25384 - - monocarboxylic acid + + + carbohydrate derivative - - - - monocarboxylic acids - ChEBI - - + - - - +1 - 0.00000 - [*+] - chebi_ontology - monoatomic monocations - monovalent inorganic cations - CHEBI:25414 - - monoatomic monocation + + + organic acid - - - - monoatomic monocations - ChEBI - - - - - monovalent inorganic cations - ChEBI - - + - - - An endogenous compound that is used to transmit information across the synapse between a neuron and another cell. - Wikipedia:Neurotransmitter - chebi_ontology - neurotransmitters - CHEBI:25512 - - neurotransmitter + + + + + polysaccharide derivative - - - - neurotransmitters - ChEBI - - + - - - - - - - - - - - 0 - N - 14.007 - 14.00307 - WebElements:N - nitrogen - chebi_ontology - 7N - N - Stickstoff - azote - nitrogen - nitrogeno - CHEBI:25555 - - nitrogen atom + + + + organic molecule - - - - nitrogen - IUPAC - - - - - - 7N - IUPAC - - - - - N - IUPAC - - - - - Stickstoff - ChEBI - - - - - azote - IUPAC - - - - - nitrogen - ChEBI - - - - - nitrogeno - ChEBI - - + - - - nonmetal + + + exopolysaccharide + + + + + + + + + Any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants. chebi_ontology - Nichtmetall - Nichtmetalle - no metal - no metales - non-metal - non-metaux - nonmetal - nonmetals - CHEBI:25585 + dietary component + dietary components + food components + CHEBI:78295 - nonmetal atom + food component - - - nonmetal - IUPAC - - - - - - Nichtmetall - ChEBI - - - - - Nichtmetalle - ChEBI - - - - - no metal - ChEBI - - - - - no metales - ChEBI - - - - - non-metal - ChEBI - - - + - non-metaux + dietary component ChEBI - + - nonmetal + dietary components ChEBI - + - nonmetals + food components ChEBI - + - - - - Any organic ion with a net negative charge. - chebi_ontology - organic anions - CHEBI:25696 - - organic anion + + + carbohydrates and carbohydrate derivatives - - - - organic anions - ChEBI - - + - - - - Any organic ion with a net positive charge. - chebi_ontology - organic cations - CHEBI:25697 - - organic cation + + A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. + CALOHA:TS-2035 + FBbt:00007002 + FMA:68646 + GO:0005623 + KUPO:0000002 + MESH:D002477 + VHOG:0001533 + WBbt:0004017 + XAO:0003012 + CL:0000000 + + The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). + cell - - - - organic cations - ChEBI - - + - - - - chebi_ontology - organic ions - CHEBI:25699 - - organic ion + + + A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment). + CARO:0000013 + cell in vivo + CL:0000003 + + To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12). + native cell - - - - organic ions - ChEBI - - + - - + + + + + + + + + + + + + - - + + - Compounds of the general formula SO3HOR where R is an organyl group - chebi_ontology - organic sulfates - CHEBI:25704 - - organic sulfate - - - - - organic sulfates - ChEBI - + + + + + + + Any fibroblast that is deriived from the neural crest. + CL:0000005 + fibroblast neural crest derived + - + - - - - An oxide is a chemical compound of oxygen with other chemical elements. - oxide - chebi_ontology - oxides - CHEBI:25741 - - oxide + + + + neuronal receptor cell (sensu Animalia) + CL:0000006 + neuronal receptor cell - - - - oxide - ChEBI - - - - - oxides - ChEBI - - + - - - - - - - - - - - 0 - O - InChI=1S/O - QVGXLLKOCUKJST-UHFFFAOYSA-N - 15.99940 - 15.99491 - [O] - KEGG:C00007 - WebElements:O - oxygen - chebi_ontology - 8O - O - Sauerstoff - oxigeno - oxygen - oxygene - CHEBI:25805 - - oxygen atom + + + A cell found in the embryo before the formation of all the gem layers is complete. + CL:0000007 + early embryonic cell (metazoa) - - - - oxygen - IUPAC - - - - - - 8O - IUPAC - - - - - O - IUPAC - - - - - Sauerstoff - ChEBI - - - - - oxigeno - ChEBI - - - - - oxygen - ChEBI - - - - - oxygene - ChEBI - - + - - - - - - - - - oxygen molecular entity - chebi_ontology - oxygen molecular entities - CHEBI:25806 - - oxygen molecular entity + + + Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination. + CL:0000008 + migratory cranial neural crest cell - - - - oxygen molecular entity - ChEBI - - - - - oxygen molecular entities - ChEBI - - + - - - - - - - - - Any peptide with hormonal activity in animals, whether endocrine, neuroendocrine, or paracrine. - chebi_ontology - peptide hormones - polypeptide hormone - CHEBI:25905 - - peptide hormone + + + Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination. + CL:0000011 + migratory trunk neural crest cell - - - - peptide hormones - ChEBI - - - - - polypeptide hormone - ChEBI - - + - - - Salts and esters of phosphoric and oligophosphoric acids and their chalcogen analogues. In inorganic chemistry, the term is also used to describe anionic coordination entities with phosphorus as central atom. - phosphates - chebi_ontology - phosphates - CHEBI:26020 - - phosphate + + + Female germ cell is a germ cell that supports female gamete production. + MA:0000388 + VHOG:0001530 + ncithesaurus:Egg + CL:0000021 + female germ cell - - - - phosphates - IUPAC - - - - - - phosphates - ChEBI - - + - - - - - - - - - - - - - - + + + + A female germ cell that has entered meiosis. + BTO:0000964 + CALOHA:TS-0711 + FBbt:00004886 + FMA:18644 + MESH:D009865 + WBbt:0006797 + oogonium + CL:0000023 + oocyte + + + + + + + + + + + + + + + + + + + - - + + - - + + + A smooth muscle cell derived from the neural crest. + CL:0000027 + smooth muscle cell neural crest derived + + + + + + + + + + + + + + + + + + + + - - + + - - + + - A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom. - 0 - H3O4P - InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4) - NBIIXXVUZAFLBC-UHFFFAOYSA-N - 97.99520 - 97.97690 - [H]OP(=O)(O[H])O[H] - Beilstein:1921286 - CAS:7664-38-2 - Drug_Central:4478 - Gmelin:2000 - HMDB:HMDB0002142 - KEGG:C00009 - KEGG:D05467 - KNApSAcK:C00007408 - PMID:11455380 - PMID:15630224 - PMID:17439666 - PMID:17518491 - PMID:22282755 - PMID:22333268 - PMID:22381614 - PMID:22401268 - Reaxys:1921286 - Wikipedia:Phosphoric_Acid - Phosphoric acid - phosphoric acid - tetraoxophosphoric acid - trihydrogen tetraoxophosphate(3-) - trihydroxidooxidophosphorus - chebi_ontology - H3PO4 - Orthophosphoric acid - Phosphate - Phosphorsaeure - Phosphorsaeureloesungen - [PO(OH)3] - acide phosphorique - acidum phosphoricum - orthophosphoric acid - CHEBI:26078 - - phosphoric acid + neuron neural crest derived + CL:0000029 + neural crest derived neuron - - - - Beilstein:1921286 - Beilstein - - - - - CAS:7664-38-2 - ChemIDplus - - - - - CAS:7664-38-2 - KEGG COMPOUND - - - - - CAS:7664-38-2 - NIST Chemistry WebBook - - - - - Drug_Central:4478 - DrugCentral - - - - - Gmelin:2000 - Gmelin - - - - - PMID:11455380 - Europe PMC - - - - - PMID:15630224 - Europe PMC - - - - - PMID:17439666 - Europe PMC - - - - - PMID:17518491 - Europe PMC - - - - - PMID:22282755 - Europe PMC - - - - - PMID:22333268 - Europe PMC - - - - - PMID:22381614 - Europe PMC - - - - - PMID:22401268 - Europe PMC - - - - - Reaxys:1921286 - Reaxys - - - - - Phosphoric acid - KEGG_COMPOUND - - - - - phosphoric acid - IUPAC - - - - - tetraoxophosphoric acid - IUPAC - - - - - - trihydrogen tetraoxophosphate(3-) - IUPAC - - - - - - trihydroxidooxidophosphorus - IUPAC - - - - - - H3PO4 - IUPAC - - - - - Orthophosphoric acid - KEGG_COMPOUND - - - - - Phosphate - KEGG_COMPOUND - - - - - Phosphorsaeure - ChEBI - - - - - Phosphorsaeureloesungen - ChEBI - - - - - [PO(OH)3] - IUPAC - - - - - acide phosphorique - ChEBI - - - - - acidum phosphoricum - ChEBI - - - - - orthophosphoric acid - NIST_Chemistry_WebBook - - + - - - - - - - - - chebi_ontology - CHEBI:26079 - - phosphoric acid derivative + + + + A cell that will develop into a neuron often after a migration phase. + CL:0000337 + BTO:0000930 + FMA:70563 + neuroblast + CL:0000031 + neuroblast (sensu Vertebrata) - + - - - - - - - - - chebi_ontology - phosphorus molecular entities - CHEBI:26082 - - phosphorus molecular entity + + + + A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. + CALOHA:TS-2086 + FMA:63368 + animal stem cell + CL:0000034 + This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’. + stem cell - - - - phosphorus molecular entities - ChEBI - - + - - - - - - - - - + + + + - - + + - 0 - Na - InChI=1S/Na - KEAYESYHFKHZAL-UHFFFAOYSA-N - 22.98977 - 22.98977 - [Na] - CAS:7440-23-5 - Gmelin:16221 - KEGG:C01330 - WebElements:Na - sodium - chebi_ontology - 11Na - Na - Natrium - natrium - sodio - sodium - CHEBI:26708 - - sodium atom + A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. + BTO:0000725 + CALOHA:TS-0448 + FMA:70337 + FMA:86475 + MESH:D006412 + VHOG:0001485 + HSC + blood forming stem cell + hemopoietic stem cell + colony forming unit hematopoietic + CL:0000037 + Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. + hematopoietic stem cell - - - - CAS:7440-23-5 - ChemIDplus - - - - - Gmelin:16221 - Gmelin - - - - - sodium - IUPAC - - - - - - 11Na - IUPAC - - - - - Na - IUPAC - - - - - Natrium - ChemIDplus - - - - - natrium - IUPAC - - - - - sodio - ChemIDplus - - - - - sodium - ChEBI - - + - - + + + - - + + - chebi_ontology - sodium compounds - sodium molecular entities - CHEBI:26712 - - sodium molecular entity + A progenitor cell committed to the erythroid lineage. + BTO:0004911 + BFU-E + CFU-E + blast forming unit erythroid + burst forming unit erythroid + colony forming unit erythroid + erythroid stem cell + CL:0000038 + erythroid progenitor cell - - - - sodium compounds - ChEBI - - - - - sodium molecular entities - ChEBI - - + - - - - - - - - - - Any alkali metal salt having sodium(1+) as the cation. - chebi_ontology - Natriumsalz - Natriumsalze - sodium salts - CHEBI:26714 - - sodium salt + + + + + A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring. + CL:0000039 + + Originally this term had some plant germ line cell children. + germ line cell - - - - Natriumsalz - ChEBI - - - - - Natriumsalze - ChEBI - - - - - sodium salts - ChEBI - - + - - - - - - - - - - Any steroid that acts as hormone. - chebi_ontology - Steroidhormon - Steroidhormone - hormona esteroide - hormonas esteroideas - hormone steroide - hormones steroides - steroid hormones - CHEBI:26764 - - steroid hormone + + + + A stem cell that can give rise to multiple lineages of cells. + FMA:84789 + multi-fate stem cell + multifate stem cell + multipotent cell + multipotent stem cell + CL:0000048 + multi fate stem cell - - - - Steroidhormon - ChEBI - - - - - Steroidhormone - ChEBI - - - - - hormona esteroide - ChEBI - - - - - hormonas esteroideas - ChEBI - - - - - hormone steroide - ChEBI - - - - - hormones steroides - ChEBI - - - - - steroid hormones - ChEBI - - + - - - - An ester of an alcohol and sulfuric acid. - 0 - O4SR2 - 96.06300 - 95.95173 - [*]OS(=O)(=O)O[*] - chebi_ontology - sulfate ester - sulfuric acid ester - sulfuric acid esters - CHEBI:26819 - - sulfuric ester + + + + A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. + BTO:0004730 + CMP + common myeloid precursor + CFU-GEMM + CFU-S + colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte + multipotential myeloid stem cell + myeloid stem cell + pluripotent stem cell (bone marrow) + CL:0000049 + This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059). + common myeloid progenitor - - - - sulfate ester - ChEBI - - - - - sulfuric acid ester - ChEBI - - - - - sulfuric acid esters - ChEBI - - + - - - Salts and esters of sulfuric acid - sulfates - chebi_ontology - sulfuric acid derivative - sulphates - CHEBI:26820 - - sulfates + + + + + A progenitor cell committed to the megakaryocyte and erythroid lineages. + CFU-EM + CFU-MegE + MEP + Meg/E progenitor + colony forming unit erythroid megakaryocyte + megakaryocyte/erythrocyte progenitor + megakaryocyte/erythroid progenitor cell + CL:0000050 + MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. + megakaryocyte-erythroid progenitor cell - - - - sulfates - ChEBI - - - - - sulfuric acid derivative - ChEBI - - - - - sulphates - ChEBI - - + - - - - - - - - - - - 0 - S - InChI=1S/S - NINIDFKCEFEMDL-UHFFFAOYSA-N - 32.06600 - 31.97207 - [S] - CAS:7704-34-9 - KEGG:C00087 - KEGG:D06527 - PPDB:605 - WebElements:S - sulfur - chebi_ontology - 16S - Elemental sulfur - S - Schwefel - azufre - soufre - sulfur - sulphur - theion - CHEBI:26833 - - sulfur atom + + + A stem cell from which all cells of the body can form. + FMA:84790 + MESH:D039901 + totipotential stem cell + CL:0000052 + totipotent stem cell - - - - CAS:7704-34-9 - ChemIDplus - - - - - CAS:7704-34-9 - NIST Chemistry WebBook - - - - - sulfur - IUPAC - - - - - - 16S - IUPAC - - - - - Elemental sulfur - KEGG_COMPOUND - - - - - S - IUPAC - - - - - S - KEGG_COMPOUND - - - - - Schwefel - ChEBI - - - - - azufre - ChEBI - - - - - soufre - ChEBI - - - - - sulfur - ChEBI - - - - - sulfur - UniProt - - - - - sulphur - ChEBI - - - - - theion - IUPAC - - + - - - - - - - - - sulfur molecular entity - chebi_ontology - sulfur molecular entities - CHEBI:26835 - - sulfur molecular entity + + + A precursor cell with a limited number of potential fates. + BTO:0000125 + FMA:84782 + blast cell + CL:0000055 + define using PATO mulit-potent or oligopotent? + non-terminally differentiated cell + + + + + + + + + A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair. + BTO:0000222 + CALOHA:TS-0650 + FBbt:00005083 + FMA:70335 + VHOG:0001529 + CL:0000056 + myoblast - - - - sulfur molecular entity - ChEBI - - - - - sulfur molecular entities - ChEBI - - + - - + + + - - + + + A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped. + BTO:0000452 + CALOHA:TS-0362 + FMA:63877 + VHOG:0001482 + CL:0000057 + These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. + fibroblast + + + + + + + + + + - - + + - A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom. - 0 - H2O4S - InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4) - QAOWNCQODCNURD-UHFFFAOYSA-N - 98.07948 - 97.96738 - [H]OS(=O)(=O)O[H] - CAS:7664-93-9 - Gmelin:2122 - KEGG:C00059 - KEGG:D05963 - KNApSAcK:C00007530 - MolBase:4 - PMID:13568755 - PMID:16122922 - PMID:19397353 - PMID:22047659 - PMID:22136045 - PMID:22204399 - PMID:22267186 - PMID:22296037 - PMID:22364556 - PMID:22435616 - PPDB:606 - Reaxys:2037554 - Wikipedia:Sulfuric_acid - Sulfuric acid - dihydrogen tetraoxosulfate - dihydroxidodioxidosulfur - hydrogen tetraoxosulfate(2-) - hydrogen tetraoxosulfate(VI) - sulfuric acid - tetraoxosulfuric acid - chebi_ontology - Acide sulfurique - Acido sulfurico - Acidum sulfuricum - H2SO4 - Schwefelsaeureloesungen - [S(OH)2O2] - [SO2(OH)2] - sulphuric acid - CHEBI:26836 - - sulfuric acid + Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell. + BTO:0003607 + FMA:66783 + chrondoplast + CL:0000058 + chondroblast - - - - CAS:7664-93-9 - ChemIDplus - - - - - CAS:7664-93-9 - KEGG COMPOUND - - - - - CAS:7664-93-9 - NIST Chemistry WebBook - - - - - Gmelin:2122 - Gmelin - - - - - PMID:13568755 - Europe PMC - - - - - PMID:16122922 - Europe PMC - - - - - PMID:19397353 - Europe PMC - - - - - PMID:22047659 - Europe PMC - - - - - PMID:22136045 - Europe PMC - - - - - PMID:22204399 - Europe PMC - - - - - PMID:22267186 - Europe PMC - - - - - PMID:22296037 - Europe PMC - - - - - PMID:22364556 - Europe PMC - - - - - PMID:22435616 - Europe PMC - - - - - Reaxys:2037554 - Reaxys - - - - - Sulfuric acid - KEGG_COMPOUND - - - - - dihydrogen tetraoxosulfate - IUPAC - - - - - - dihydroxidodioxidosulfur - IUPAC - - - - - - hydrogen tetraoxosulfate(2-) - IUPAC - - - - - - hydrogen tetraoxosulfate(VI) - IUPAC - - - - - - sulfuric acid - ChEBI - - - - - sulfuric acid - IUPAC - - - - - - tetraoxosulfuric acid - IUPAC - - - - - - Acide sulfurique - ChemIDplus - - - - - Acido sulfurico - ChemIDplus - - - - - Acidum sulfuricum - ChemIDplus - - - - - H2SO4 - IUPAC - - - - - Schwefelsaeureloesungen - ChemIDplus - - - - - [S(OH)2O2] - MolBase - - - - - [SO2(OH)2] - IUPAC - - - - - sulphuric acid - MolBase - - + - - - - A natural pigment containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. - tetrapyrrole - tetrapyrroles - chebi_ontology - a tetrapyrrole - CHEBI:26932 - - tetrapyrrole + + + A cell that has a filiform extrusion of the cell surface. + VHOG:0001532 + XAO:0000031 + CL:0000064 + ciliated cell - - - - tetrapyrrole - IUPAC - - - - - - tetrapyrroles - IUPAC - - - - - - a tetrapyrrole - UniProt - - + - - - Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions. - Wikipedia:Micronutrient - chebi_ontology - micronutrients - trace elements - CHEBI:27027 - - micronutrient + + + + A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina. + BTO:0000414 + CALOHA:TS-2026 + CARO:0000077 + FBbt:00000124 + FMA:66768 + WBbt:0003672 + epitheliocyte + CL:0000066 + epithelial cell - - - - micronutrients - ChEBI - - - - - trace elements - ChEBI - - + - - - Tryptamine and its substitution derivatives. - chebi_ontology - CHEBI:27162 - - tryptamines + + + + An epithelial cell that has a cilia. + FMA:70605 + CL:0000067 + ciliated epithelial cell - + - - - - chebi_ontology - heterobicyclic compounds - organic heterobicyclic compounds - CHEBI:27171 - - organic heterobicyclic compound + + + + An epithelial cell that is part of a duct. + CL:0000068 + duct epithelial cell - - - - heterobicyclic compounds - ChEBI - - - - - organic heterobicyclic compounds - ChEBI - - + - - - A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid. - chebi_ontology - univalent acyl group - univalent carboacyl groups - univalent carboxylic acyl groups - CHEBI:27207 - - univalent carboacyl group + + + CL:0000069 + branched duct epithelial cell - - - - univalent acyl group - ChEBI - - - - - univalent carboacyl groups - ChEBI - - - - - univalent carboxylic acyl groups - ChEBI - - + - - - A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer). - zwitterion - zwitterions - chebi_ontology - compose zwitterionique - compuestos zwitterionicos - zwitteriones - zwitterionic compounds - CHEBI:27369 - - zwitterion + + + + + + + + + + An endothelial cell that lines the vasculature. + cuboidal endothelial cell of vascular tree + CL:0000071 + blood vessel endothelial cell - - - - zwitterion - IUPAC - - - - - - zwitterions - IUPAC - - - - - - compose zwitterionique - IUPAC - - - - - compuestos zwitterionicos - IUPAC - - - - - zwitteriones - IUPAC - - - - - zwitterionic compounds - IUPAC - - + - - - - - - - - - - - 0 - C - InChI=1S/C - OKTJSMMVPCPJKN-UHFFFAOYSA-N - 12.01070 - 12.00000 - [C] - CHEBI:23009 - CHEBI:3399 - CAS:7440-44-0 - KEGG:C06265 - WebElements:C - carbon - chebi_ontology - 6C - C - Carbon - Kohlenstoff - carbon - carbone - carbonium - carbono - CHEBI:27594 - - carbon atom + + + + A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. + CL:0000075 + columnar/cuboidal epithelial cell - - - - CAS:7440-44-0 - ChemIDplus - - - - - CAS:7440-44-0 - KEGG COMPOUND - - - - - carbon - IUPAC - - - - - - 6C - IUPAC - - - - - C - IUPAC - - - - - C - KEGG_COMPOUND - - - - - Carbon - KEGG_COMPOUND - - - - - Kohlenstoff - ChEBI - - - - - carbon - ChEBI - - - - - carbone - ChEBI - - - - - carbonium - ChEBI - - - - - carbono - ChEBI - - + - - - - - - - - - - - - - - - - A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues. - CHEBI:24379 - CHEBI:5466 - CAS:9005-79-2 - GlyGen:G99991IU - GlyTouCan:G99991IU - HMDB:HMDB0000757 - KEGG:C00182 - MetaCyc:CPD0-971 - Wikipedia:Glycogen - Glycogen - chebi_ontology - WURCS=2.0/1,4,3/[a2122h-1a_1-5]/1-1-1-1/a4-b1_b4-c1_b6-d1 - animal starch - liver starch - CHEBI:28087 - - glycogen + + + CALOHA:TS-1249 + CL:0000076 + squamous epithelial cell - - - - CAS:9005-79-2 - ChemIDplus - - - - - CAS:9005-79-2 - KEGG COMPOUND - - - - - Glycogen - KEGG_COMPOUND - - - - - WURCS=2.0/1,4,3/[a2122h-1a_1-5]/1-1-1-1/a4-b1_b4-c1_b6-d1 - GlyTouCan - - - - - animal starch - ChemIDplus - - - - - liver starch - ChemIDplus - - + - - - - - - - - - - - - - - - - - A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised. - 0 - CH3NO2 - InChI=1S/CH3NO2/c2-1(3)4/h2H2,(H,3,4) - KXDHJXZQYSOELW-UHFFFAOYSA-N - 61.04006 - 61.01638 - NC(O)=O - CHEBI:22504 - CHEBI:23002 - CHEBI:3386 - CHEBI:44573 - Beilstein:1734754 - CAS:463-77-4 - DrugBank:DB04261 - Gmelin:130345 - KEGG:C01563 - PDBeChem:OUT - Wikipedia:Carbamic_acid - CARBAMIC ACID - Carbamic acid - carbamic acid - chebi_ontology - Aminoameisensaeure - Aminoformic acid - Carbamate - Carbamidsaeure - CHEBI:28616 - - carbamic acid + + + + + A flattened epithelial cell of mesenchymal origin that lines the serous cavity. + FMA:66773 + mesotheliocyte + CL:0000077 + mesothelial cell - - - - Beilstein:1734754 - Beilstein - - - - - CAS:463-77-4 - ChemIDplus - - - - - CAS:463-77-4 - KEGG COMPOUND - - - - - Gmelin:130345 - Gmelin - - - - - CARBAMIC ACID - PDBeChem - - - - - Carbamic acid - KEGG_COMPOUND - - - - - carbamic acid - IUPAC - - - - - - Aminoameisensaeure - ChEBI - - - - - Aminoformic acid - KEGG_COMPOUND - - - - - Carbamate - KEGG_COMPOUND - - - - - Carbamidsaeure - ChEBI - - + - - - - - - - - - - - 0 - P - InChI=1S/P - OAICVXFJPJFONN-UHFFFAOYSA-N - 30.97376 - 30.97376 - [P] - CHEBI:26080 - CHEBI:8168 - CAS:7723-14-0 - Gmelin:16235 - KEGG:C06262 - WebElements:P - phosphorus - chebi_ontology - 15P - P - Phosphor - Phosphorus - fosforo - phosphore - phosphorus - CHEBI:28659 - - phosphorus atom + + + + A cell found predominately in the blood. + FMA:62844 + MESH:D001773 + CL:0000081 + blood cell - - - - CAS:7723-14-0 - ChemIDplus - - - - - CAS:7723-14-0 - KEGG COMPOUND - - - - - Gmelin:16235 - Gmelin - - - - - phosphorus - IUPAC - - - - - - 15P - IUPAC - - - - - P - IUPAC - - - - - P - KEGG_COMPOUND - - - - - Phosphor - ChEBI - - - - - Phosphorus - KEGG_COMPOUND - - - - - fosforo - ChEBI - - - - - phosphore - ChEBI - - - - - phosphorus - ChEBI - - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + - - + + - A primary amino compound that is the 5-hydroxy derivative of tryptamine. - 0 - C10H12N2O - InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 - QZAYGJVTTNCVMB-UHFFFAOYSA-N - 176.215 - 176.09496 - C1=CC(=CC=2C(=CNC12)CCN)O - CHEBI:1420 - CHEBI:26652 - CHEBI:49894 - Beilstein:143524 - CAS:50-67-9 - Gmelin:1861995 - HMDB:HMDB0000259 - KEGG:C00780 - KNApSAcK:C00001429 - LINCS:LSM-6589 - MetaCyc:SEROTONIN - PDBeChem:SRO - PMID:18593914 - PMID:22770225 - PMID:24136337 - Reaxys:143524 - Wikipedia:Serotonin - 3-(2-aminoethyl)-1H-indol-5-ol - SEROTONIN - Serotonin - chebi_ontology - 3-(2-Aminoethyl)-1H-indol-5-ol - 5-HT - 5-Hydroxytryptamine - Enteramine - serotonine - thrombocytin - thrombotonin - CHEBI:28790 - - serotonin + An epithelial cell of the pancreas. + BTO:0000028 + pancreas epithelial cell + pancreatic epithelial cell + CL:0000083 + epithelial cell of pancreas - - - - Beilstein:143524 - Beilstein - - - - - CAS:50-67-9 - ChemIDplus - - - - - CAS:50-67-9 - KEGG COMPOUND - - - - - Gmelin:1861995 - Gmelin - - - - - PMID:18593914 - Europe PMC - - - - - PMID:22770225 - Europe PMC - - - - - PMID:24136337 - Europe PMC - - - - - Reaxys:143524 - Reaxys - - - - - 3-(2-aminoethyl)-1H-indol-5-ol - IUPAC - - - - - - SEROTONIN - PDBeChem - - - - - Serotonin - KEGG_COMPOUND - - - - - 3-(2-Aminoethyl)-1H-indol-5-ol - KEGG_COMPOUND - - - - - 5-HT - IUPHAR - - - - - 5-Hydroxytryptamine - KEGG_COMPOUND - - - - - Enteramine - KEGG_COMPOUND - - - - - serotonine - ChEBI - - - - - thrombocytin - ChemIDplus - - - - - thrombotonin - ChemIDplus - - + - - - - - - - - - - - - - - - - - + + + - - + + - - - - - - - - - - - - - An onium cation obtained by protonation of ammonia. - +1 - H4N - InChI=1S/H3N/h1H3/p+1 - QGZKDVFQNNGYKY-UHFFFAOYSA-O - 18.03850 - 18.03383 - [H][N+]([H])([H])[H] - CHEBI:22534 - CHEBI:49783 - CHEBI:7435 - CAS:14798-03-9 - Gmelin:84 - KEGG:C01342 - MetaCyc:AMMONIUM - MolBase:929 - PDBeChem:NH4 - PMID:11319011 - PMID:11341317 - PMID:12096804 - PMID:14512268 - PMID:14879753 - PMID:16345391 - PMID:16903292 - PMID:17392693 - PMID:18515490 - PMID:19199063 - PMID:19596600 - PMID:19682559 - PMID:19716251 - PMID:21993530 - PMID:22265469 - PMID:22524020 - PMID:22562341 - PMID:22631217 - Reaxys:16093784 - Wikipedia:Ammonium - ammonium - azanium - chebi_ontology - Ammonium(1+) - NH4(+) - NH4+ - [NH4](+) - ammonium cation - ammonium ion - CHEBI:28938 - - ammonium + CL:0000095 + neuron associated cell - - - - CAS:14798-03-9 - ChemIDplus - - - - - CAS:14798-03-9 - NIST Chemistry WebBook - - - - - Gmelin:84 - Gmelin - - - - - PMID:11319011 - Europe PMC - - - - - PMID:11341317 - Europe PMC - - - - - PMID:12096804 - Europe PMC - - - - - PMID:14512268 - Europe PMC - - - - - PMID:14879753 - Europe PMC - - - - - PMID:16345391 - Europe PMC - - - - - PMID:16903292 - Europe PMC - - - - - PMID:17392693 - Europe PMC - - - - - PMID:18515490 - Europe PMC - - - - - PMID:19199063 - Europe PMC - - - - - PMID:19596600 - Europe PMC - - - - - PMID:19682559 - Europe PMC - - - - - PMID:19716251 - Europe PMC - - - - - PMID:21993530 - Europe PMC - - - - - PMID:22265469 - Europe PMC - - - - - PMID:22524020 - Europe PMC - - - - - PMID:22562341 - Europe PMC - - - - - PMID:22631217 - Europe PMC - - - - - Reaxys:16093784 - Reaxys - - - - - ammonium - ChEBI - - - - - ammonium - IUPAC - - - - - - azanium - IUPAC - - - - - - Ammonium(1+) - ChemIDplus - - - - - NH4(+) - IUPAC - - - - - NH4(+) - UniProt - - - - - NH4+ - KEGG_COMPOUND - - - - - [NH4](+) - MolBase - - - - - ammonium cation - ChemIDplus - - - - - ammonium ion - PDBeChem - - + - - - - A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid. - -2 - C2O4R - 88.019 - 87.97966 - [O-]C(=O)[*]C([O-])=O - CHEBI:13632 - CHEBI:23688 - CHEBI:23689 - CHEBI:38711 - dicarboxylic acid dianion - chebi_ontology - a dicarboxylate - dicarboxylate - dicarboxylates - dicarboxylic acid dianions - CHEBI:28965 - - dicarboxylic acid dianion + + + Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions. + BTO:0003811 + FBbt:00005125 + FMA:67313 + WBbt:0005113 + CL:0000099 + interneuron - - - - dicarboxylic acid dianion - ChEBI - - - - - a dicarboxylate - UniProt - - - - - dicarboxylate - ChEBI - - - - - dicarboxylates - ChEBI - - - - - dicarboxylic acid dianions - ChEBI - - + - - - - - - - - - - - - - - - - 0 - CH2O3 - InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4) - BVKZGUZCCUSVTD-UHFFFAOYSA-N - 62.02478 - 62.00039 - OC(O)=O - CHEBI:13351 - CHEBI:23017 - CHEBI:23744 - CHEBI:3401 - CAS:463-79-6 - Gmelin:25554 - KEGG:C01353 - PDBeChem:CO3 - Carbonic acid - carbonic acid - dihydroxidooxidocarbon - chebi_ontology - Dihydrogen carbonate - H2CO3 - Koehlensaeure - [CO(OH)2] - CHEBI:28976 - - carbonic acid + + + An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement. + BTO:0000312 + FBbt:00005123 + FMA:83617 + WBbt:0005409 + motoneuron + CL:0000100 + motor neuron - - - - CAS:463-79-6 - ChemIDplus - - - - - CAS:463-79-6 - KEGG COMPOUND - - - - - Gmelin:25554 - Gmelin - - - - - Carbonic acid - KEGG_COMPOUND - - - - - carbonic acid - IUPAC - - - - - - dihydroxidooxidocarbon - IUPAC - - - - - - Dihydrogen carbonate - KEGG_COMPOUND - - - - - H2CO3 - IUPAC - - - - - H2CO3 - KEGG_COMPOUND - - - - - Koehlensaeure - ChEBI - - - - - [CO(OH)2] - IUPAC - - + - - - - - - - - - - The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated. - -1 - CO2R - 44.00950 - 43.98983 - [O-]C([*])=O - CHEBI:13626 - CHEBI:13945 - CHEBI:23026 - CHEBI:58657 - chebi_ontology - a carboxylate - carboxylic acid anions - carboxylic anions - CHEBI:29067 - - carboxylic acid anion + + + Any neuron having a sensory function; an afferent neuron conveying sensory impulses. + BTO:0001037 + FBbt:00005124 + FMA:84649 + MESH:D011984 + WBbt:0005759 + CL:0000101 + sensory neuron - - - - a carboxylate - UniProt - - - - - carboxylic acid anions - ChEBI - - - - - carboxylic anions - ChEBI - - + - - - - - - - - - - - - - - - - - - - A monoatomic monocation obtained from sodium. - +1 - Na - InChI=1S/Na/q+1 - FKNQFGJONOIPTF-UHFFFAOYSA-N - 22.98977 - 22.98922 - [Na+] - CHEBI:26717 - CHEBI:49766 - CHEBI:9175 - CAS:17341-25-2 - Gmelin:15196 - KEGG:C01330 - PDBeChem:NA - sodium cation - sodium(1+) - sodium(1+) ion - sodium(I) cation - chebi_ontology - Na(+) - Na+ - SODIUM ION - CHEBI:29101 - - sodium(1+) + + + + An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm. + BTO:0001176 + CALOHA:TS-0278 + FMA:66772 + endotheliocyte + CL:0000115 + From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]. + endothelial cell - - - - CAS:17341-25-2 - ChemIDplus - - - - - CAS:17341-25-2 - NIST Chemistry WebBook - - - - - Gmelin:15196 - Gmelin - - - - - sodium cation - IUPAC - - - - - - sodium(1+) - IUPAC - - - - - - sodium(1+) ion - IUPAC - - - - - - sodium(I) cation - IUPAC - - - - - - Na(+) - IUPAC - - - - - Na(+) - UniProt - - - - - Na+ - KEGG_COMPOUND - - - - - SODIUM ION - PDBeChem - - + - - - - - - - - - + + + - - + + - -1 - H2N - InChI=1S/H2N/h1H2/q-1 - HYGWNUKOUCZBND-UHFFFAOYSA-N - 16.02262 - 16.01927 - [H][N-][H] - amide - azanide - dihydridonitrate(1-) - chebi_ontology - NH2(-) - CHEBI:29337 - - azanide + CL:0000117 + CNS neuron (sensu Vertebrata) - - - - amide - IUPAC - - - - - - azanide - IUPAC - - - - - - dihydridonitrate(1-) - IUPAC - - - - - - NH2(-) - IUPAC - - + - - - - - - - - - - A divalent inorganic anion resulting from the removal of two protons from ammonia. - -2 - HN - InChI=1S/HN/h1H/q-2 - DZQYTNGKSBCIOE-UHFFFAOYSA-N - 15.01468 - 15.01200 - [N--][H] - azanediide - hydridonitrate(2-) - chebi_ontology - NH(2-) - imide - CHEBI:29340 - - hydridonitrate(2-) + + + A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons. + BTO:0002606 + CALOHA:TS-0415 + FBbt:00005144 + FMA:54536 + neuroglial cell + neuroglia + CL:0000125 + Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571 + glial cell - - - - azanediide - IUPAC - - - - - - hydridonitrate(2-) - IUPAC - - - - - - NH(2-) - IUPAC - - - - - imide - IUPAC - - + - - - - - - - - - +1 - HO2 - InChI=1S/O2/c1-2/p+1 - MYMOFIZGZYHOMD-UHFFFAOYSA-O - 33.00674 - 32.99711 - [H][O+]=O - Gmelin:508 - dioxidenium - hydridodioxygen(1+) - chebi_ontology - HO2(+) - HOO(+) - [HO2](+) - CHEBI:29793 - - hydridodioxygen(1+) + + + Ectoderm destined to be nervous tissue. + neurectoderm cell + CL:0000133 + neurectodermal cell - - - - Gmelin:508 - Gmelin - - - - - dioxidenium - IUPAC - - - - - - hydridodioxygen(1+) - IUPAC - - - - - - HO2(+) - IUPAC - - - - - HOO(+) - ChEBI - - - - - [HO2](+) - ChEBI - - + - - - - - - - - - + + + + A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs. + CL:0002452 + BTO:0002625 + BTO:0003298 + FMA:70546 + BMSC + bone marrow stromal cells + colony-forming unit-fibroblast + marrow stromal cells + CFU-F + MSC + mesenchymal precursor cell + mesenchymal progenitor cells + mesenchymal stem cell + mesenchymal stromal cell + mesenchymal stromal cells + stem cells, mesenchymal + CL:0000134 + Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. + mesenchymal stem cell + https://github.com/obophenotype/cell-ontology/issues/474 + + + + + + + + + + - - + + + A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides. + CL:0000450 + BTO:0000443 + CALOHA:TS-0012 + FMA:63880 + adipocyte + adipose cell + CL:0000136 + fat cell + + + + + + + + + - - + + - A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid. - -1 - C2H3O2 - InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 - QTBSBXVTEAMEQO-UHFFFAOYSA-M - 59.04402 - 59.01385 - CC([O-])=O - CHEBI:13704 - CHEBI:22165 - CHEBI:40480 - Beilstein:1901470 - CAS:71-50-1 - DrugBank:DB03166 - Gmelin:1379 - KEGG:C00033 - MetaCyc:ACET - PDBeChem:ACT - PMID:17190852 - PMID:22211106 - PMID:22371380 - Reaxys:1901470 - UM-BBD_compID:c0050 - Wikipedia:Acetate - acetate - chebi_ontology - ACETATE ION - Azetat - CH3-COO(-) - Ethanoat - MeCO2 anion - acetic acid, ion(1-) - ethanoate - CHEBI:30089 - - acetate + Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell. + BTO:0000249 + CALOHA:TS-0138 + FMA:66782 + cartilage cell + CL:0000138 + chondrocyte - - - - Beilstein:1901470 - Beilstein - - - - - CAS:71-50-1 - ChemIDplus - - - - - CAS:71-50-1 - NIST Chemistry WebBook - - - - - Gmelin:1379 - Gmelin - - - - - PMID:17190852 - Europe PMC - - - - - PMID:22211106 - Europe PMC - - - - - PMID:22371380 - Europe PMC - - - - - Reaxys:1901470 - Reaxys - - - - - UM-BBD_compID:c0050 - UM-BBD - - - - - acetate - IUPAC - - - - - - acetate - UniProt - - - - - ACETATE ION - PDBeChem - - - - - Azetat - ChEBI - - - - - CH3-COO(-) - IUPAC - - - - - Ethanoat - ChEBI - - - - - MeCO2 anion - NIST_Chemistry_WebBook - - - - - acetic acid, ion(1-) - ChemIDplus - - - - - ethanoate - ChEBI - - + - - Particle of zero charge, zero rest mass, spin quantum number 1, energy hnu and momentum hnu/c (h is the Planck constant, nu the frequency of radiation and c the speed of light), carrier of electromagnetic force. - 0 - 0.0 - 0.0 - * - CHEBI:10581 - CHEBI:14383 - KEGG:C00205 - photon - chebi_ontology - Lichtquant - Light - foton - gamma - hnu - light quantum - CHEBI:30212 - - photon + + + A pigment cell is a cell that contains pigment granules. + VHOG:0001678 + chromatocyte + chromatophore + CL:0000147 + pigment cell - - - - photon - IUPAC - - - - - - Lichtquant - ChEBI - - - - - Light - KEGG_COMPOUND - - - - - foton - ChEBI - - - - - gamma - IUPAC - - - - - hnu - IUPAC - - - - - hnu - UniProt - - - - - light quantum - ChEBI - - + - - - - Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration. - KEGG:C01558 - Bile acid - chebi_ontology - 5beta-bile acid - 5beta-bile acids - Bile salt - Gallensaeure - Gallensaeuren - bile acids - CHEBI:3098 - - bile acid + + + pigment cell + CL:0000149 + visual pigment cell - - - - Bile acid - KEGG_COMPOUND - - - - - 5beta-bile acid - ChEBI - - - - - 5beta-bile acids - ChEBI - - - - - Bile salt - KEGG_COMPOUND - - - - - Gallensaeure - ChEBI - - - - - Gallensaeuren - ChEBI - - - - - bile acids - ChEBI - - + - - - A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. - CHEBI:13814 - CHEBI:22474 - CHEBI:2641 - KEGG:C00706 - Amine - amines - chebi_ontology - Amin - Substituted amine - CHEBI:32952 - - amine + + + + + A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules. + CALOHA:TS-2085 + FMA:86494 + CL:0000150 + glandular epithelial cell - - - - Amine - KEGG_COMPOUND - - - - - amines - IUPAC - - - - - - Amin - ChEBI - - - - - Substituted amine - KEGG_COMPOUND - - + - - - An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group. - CHEBI:22473 - CHEBI:2633 - KEGG:C00241 - Amide - amides - chebi_ontology - CHEBI:32988 - - amide - - - - - Amide - KEGG_COMPOUND - - - - - amides - IUPAC - - - - - - - - - - Intended use of the molecular entity or part thereof by humans. - chebi_ontology - CHEBI:33232 - - application + + + + A cell that specializes in controlled release of one or more substances. + BTO:0003659 + FMA:86916 + CL:0000151 + secretory cell - + - - - A monoatomic entity is a molecular entity consisting of a single atom. - chebi_ontology - atomic entity - monoatomic entities - CHEBI:33238 - - monoatomic entity + + + A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct. + FMA:16014 + CL:0000152 + exocrine cell - - - - atomic entity - ChEBI - - - - - monoatomic entities - ChEBI - - + - - - - - - - - - chebi_ontology - oxoacid derivatives - CHEBI:33241 - - oxoacid derivative + + + + A cell that secretes glycosaminoglycans. + GAG secreting cell + hyaluronic acid secreting cell + CL:0000153 + glycosaminoglycan secreting cell - - - - oxoacid derivatives - ChEBI - - + - - - - chebi_ontology - inorganic hydrides - CHEBI:33242 - - inorganic hydride + + + CL:0000154 + protein secreting cell - - - - inorganic hydrides - ChEBI - - + - - - - An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system. - chebi_ontology - organic fundamental parents - organic parent hydrides - CHEBI:33245 - - organic fundamental parent + + + A cell that specializes in secretion of surfactant in the alveoli of the lung. + CL:0000157 + surfactant secreting cell - - - - organic fundamental parents - ChEBI - - - - - organic parent hydrides - ChEBI - - + - - - Any substituent group which does not contain carbon. - chebi_ontology - inorganic groups - CHEBI:33246 - - inorganic group + + + + Epithelial progenitor cell of the lung. Club cells are dome-shaped with short microvilli but no cilia. They function to protect the bronchiolar epithelium. Club cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium. + BTO:0004811 + FMA:14119 + Clara cell + bronchiolar non-ciliated cell + club cell of bronchiole + CL:0000158 + club cell - - - - inorganic groups - ChEBI - - + - - - - - - - - - Any substituent group or skeleton containing carbon. - chebi_ontology - organic groups - CHEBI:33247 - - organic group + + + CL:0000159 + seromucus secreting cell - - - - organic groups - ChEBI - - + - - - Any organic substituent group, regardless of functional type, having one free valence at a carbon atom. - organyl group - organyl groups - chebi_ontology - groupe organyle - grupo organilo - grupos organilo - CHEBI:33249 - - organyl group + + + A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions. + FMA:83809 + endocrinocyte + CL:0000163 + endocrine cell - - - - organyl group - IUPAC - - - - - - organyl groups - IUPAC - - - - - - groupe organyle - IUPAC - - - - - grupo organilo - IUPAC - - - - - grupos organilo - IUPAC - - + - - - - - - - - - - - - - - - A chemical entity constituting the smallest component of an element having the chemical properties of the element. - CHEBI:22671 - CHEBI:23907 - atom - chebi_ontology - atome - atomo - atoms - atomus - element - elements - CHEBI:33250 - - atom + + + + An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas. + BTO:0003865 + FMA:62930 + MESH:D019858 + CL:0000164 + enteroendocrine cell - - - - atom - IUPAC - - - - - - atome - IUPAC - - - - - atomo - IUPAC - - - - - atoms - ChEBI - - - - - atomus - ChEBI - - - - - element - ChEBI - - - - - elements - ChEBI - - + - - - - - - - - - A nucleus is the positively charged central portion of an atom, excluding the orbital electrons. - nucleus - chebi_ontology - Atomkern - Kern - noyau - noyau atomique - nuclei - nucleo - nucleo atomico - nucleus atomi - CHEBI:33252 - - atomic nucleus + + + + + An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals. + BTO:0002691 + FMA:83810 + neurosecretory cell + CL:0000165 + neuroendocrine cell - - - - nucleus - IUPAC - - - - - - Atomkern - ChEBI - - - - - Kern - ChEBI - - - - - noyau - IUPAC - - - - - noyau atomique - ChEBI - - - - - nuclei - ChEBI - - - - - nucleo - IUPAC - - - - - nucleo atomico - ChEBI - - - - - nucleus atomi - ChEBI - - + - - - Heavy nuclear particle: proton or neutron. - nucleon - chebi_ontology - Nukleon - Nukleonen - nucleons - CHEBI:33253 - - nucleon + + + CL:0000167 + peptide hormone secreting cell - - - - nucleon - IUPAC - - - - - nucleon - IUPAC - - - - - - Nukleon - ChEBI - - - - - Nukleonen - ChEBI - - - - - nucleons - ChEBI - - + - - - A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group. - primary amide - primary amides - chebi_ontology - CHEBI:33256 - - primary amide + + + + BTO:0000783 + CL:0000168 + insulin secreting cell - - - - primary amide - IUPAC - - - - - primary amides - IUPAC - - - + - - - A molecular entity all atoms of which have the same atomic number. - chebi_ontology - homoatomic entity - homoatomic molecular entities - homoatomic molecular entity - CHEBI:33259 - - elemental molecular entity + + + A cell that secretes glucagon. + FMA:84045 + glucagon-secreting cell + CL:0000170 + glucagon secreting cell - - - - homoatomic entity - ChEBI - - - - - homoatomic molecular entities - ChEBI - - - - - homoatomic molecular entity - ChEBI - - + - - - - - chebi_ontology - CHEBI:33262 - - elemental oxygen + + + CL:0000172 + somatostatin secreting cell - + - - - 0 - O2 - 31.999 - 31.98983 - chebi_ontology - CHEBI:33263 - - diatomic oxygen + + + CL:0000174 + steroid hormone secreting cell - + - - - - An anion consisting of more than one atom. - chebi_ontology - polyatomic anions - CHEBI:33273 - - polyatomic anion + + + + + + + + + + + + The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated. + BTO:0000575 + CALOHA:TS-0454 + FMA:14515 + CL:0000182 + Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive. + hepatocyte - - - - polyatomic anions - ChEBI - - + - - - chebi_ontology - chemical messenger - CHEBI:33280 - - molecular messenger + + + A cell whose primary function is to shorten. + CL:0000183 + contractile cell - - - - chemical messenger - ChEBI - - + - - - A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. - CHEBI:22582 - PMID:12964249 - PMID:22117953 - PMID:22439833 - PMID:22849268 - PMID:22849276 - PMID:22958833 - chebi_ontology - Antibiotika - Antibiotikum - antibiotic - antibiotics - antibiotique - antimicrobial - antimicrobial agents - antimicrobials - microbicide - microbicides - CHEBI:33281 - - antimicrobial agent + + + + + + + + + + + + + A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. + BTO:0000888 + BTO:0000902 + CALOHA:TS-2032 + FBbt:00005074 + FMA:67328 + WBbt:0003675 + muscle fiber + myocyte + CL:0000187 + muscle cell - - - - PMID:12964249 - Europe PMC - - - - - PMID:22117953 - Europe PMC - - - - - PMID:22439833 - Europe PMC - - - - - PMID:22849268 - Europe PMC - - - - - PMID:22849276 - Europe PMC - - - - - PMID:22958833 - Europe PMC - - - - - Antibiotika - ChEBI - - - - - Antibiotikum - ChEBI - - - - - antibiotic - ChEBI - - - - - antibiotics - ChEBI - - - - - antibiotique - IUPAC - - - - - antimicrobial - ChEBI - - - - - antimicrobial agents - ChEBI - - - - - antimicrobials - ChEBI - - - - - microbicide - ChEBI - - - - - microbicides - ChEBI - - + - - - A nutrient is a food component that an organism uses to survive and grow. - chebi_ontology - nutrients - CHEBI:33284 - - nutrient + + + + A somatic cell located in skeletal muscle. + BTO:0004392 + CALOHA:TS-2158 + FMA:9727 + skeletal muscle cell + CL:0000188 + cell of skeletal muscle - - - - nutrients - ChEBI - - + - - - A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms. - chebi_ontology - heteroorganic entities - organoelement compounds - CHEBI:33285 - - heteroorganic entity + + + + + + + + + + A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast). + CL:0000191 + non-striated muscle cell + BTO:0004576 + CALOHA:TS-2159 + FMA:14072 + SMCs + myocytes, smooth muscle + smooth muscle fiber + CL:0000192 + smooth muscle cell - - - - heteroorganic entities - ChEBI - - - - - organoelement compounds - ChEBI - - + - - - An agrochemical is a substance that is used in agriculture or horticulture. - Wikipedia:Agrochemical - chebi_ontology - agrichemical - agrichemicals - agricultural chemicals - agrochemicals - CHEBI:33286 - - agrochemical + + + + A cell that is capable of detection of a stimulus involved in sensory perception. + MESH:D011984 + receptor cell + CL:0000197 + sensory receptor cell - - - - agrichemical - ChEBI - - - - - agrichemicals - ChEBI - - - - - agricultural chemicals - ChEBI - - - - - agrochemicals - ChEBI - - + - - - A fertilizer is any substance that is added to soil or water to assist the growth of plants. - chebi_ontology - fertiliser - fertilizers - CHEBI:33287 - - fertilizer + + + A cell specialized to detect and transduce light. + BTO:0001060 + CALOHA:TS-0868 + FMA:86740 + CL:0000210 + photoreceptor cell - - - - fertiliser - ChEBI - - - - - fertilizers - ChEBI - - + - - - - - - - - - A molecular entity containing one or more atoms of an alkali metal. - chebi_ontology - alkali metal molecular entities - CHEBI:33296 - - alkali metal molecular entity + + + A cell whose function is determined by the generation or the reception of an electric signal. + CL:0000211 + electrically active cell - - - - alkali metal molecular entities - ChEBI - - + - - - Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth. - pnictogens - chebi_ontology - group 15 elements - group V elements - nitrogenoideos - nitrogenoides - pnictogene - pnictogenes - CHEBI:33300 - - pnictogen + + + A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism. + boundary cell + CL:0000213 + lining cell - - - - pnictogens - IUPAC - - - - - - group 15 elements - ChEBI - - - - - group V elements - ChEBI - - - - - nitrogenoideos - ChEBI - - - - - nitrogenoides - ChEBI - - - - - pnictogene - ChEBI - - - - - pnictogenes - ChEBI - - + - - - - - - - - - A p-block molecular entity containing any pnictogen. - pnictogen molecular entity - chebi_ontology - pnictogen molecular entities - CHEBI:33302 - - pnictogen molecular entity + + + + + A cell located in the synovial joint. + CALOHA:TS-0995 + synoviocyte + CL:0000214 + synovial cell - - - - pnictogen molecular entity - ChEBI - - - - - pnictogen molecular entities - ChEBI - - + - - - Any p-block element belonging to the group 16 family of the periodic table. - PMID:17084588 - chalcogen - chalcogens - chebi_ontology - Chalkogen - Chalkogene - anfigeno - anfigenos - calcogeno - calcogenos - chalcogene - chalcogenes - group 16 elements - group VI elements - CHEBI:33303 - - chalcogen + + + A cell whose primary function is to prevent the transport of stuff across compartments. + CL:0000215 + barrier cell - - - - PMID:17084588 - Europe PMC - - - - - chalcogen - IUPAC - - - - - - chalcogens - IUPAC - - - - - - Chalkogen - ChEBI - - - - - Chalkogene - ChEBI - - - - - anfigeno - ChEBI - - - - - anfigenos - ChEBI - - - - - calcogeno - ChEBI - - - - - calcogenos - ChEBI - - - - - chalcogene - ChEBI - - - - - chalcogenes - ChEBI - - - - - group 16 elements - ChEBI - - - - - group VI elements - ChEBI - - + - - - - - - - - - Any p-block molecular entity containing a chalcogen. - chalcogen molecular entity - chebi_ontology - chalcogen compounds - chalcogen molecular entities - CHEBI:33304 - - chalcogen molecular entity + + + + A cell that moves by its own activities. + CL:0000219 + motile cell - - - - chalcogen molecular entity - ChEBI - - - - - chalcogen compounds - ChEBI - - - - - chalcogen molecular entities - ChEBI - - + - - - group 14 elements - chebi_ontology - carbon group element - carbon group elements - carbonoides - cristallogene - cristallogenes - group IV elements - CHEBI:33306 - - carbon group element atom + + + + A cell of the outer of the three germ layers of the embryo. + FMA:72549 + ectoderm cell + CL:0000221 + ectodermal cell - - - - group 14 elements - IUPAC - - - - - - carbon group element - ChEBI - - - - - carbon group elements - ChEBI - - - - - carbonoides - ChEBI - - - - - cristallogene - ChEBI - - - - - cristallogenes - ChEBI - - - - - group IV elements - ChEBI - - + - - - - An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl. - 0 - CO2R2 - 44.010 - 43.98983 - [*]C(=O)O[*] - CHEBI:13204 - CHEBI:23028 - CHEBI:3408 - KEGG:C02391 - Wikipedia:Ester - Carboxylic ester - carboxylic esters - chebi_ontology - a carboxylic ester - carboxylic acid esters - CHEBI:33308 - - carboxylic ester + + + + A cell of the middle germ layer of the embryo. + FMA:72554 + mesoblast + mesoderm cell + CL:0000222 + mesodermal cell - - - - Carboxylic ester - KEGG_COMPOUND - - - - - carboxylic esters - IUPAC - - - - - - a carboxylic ester - UniProt - - - - - carboxylic acid esters - ChEBI - - + - - - An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table. - main group elements - chebi_ontology - Hauptgruppenelement - Hauptgruppenelemente - main group element - CHEBI:33318 - - main group element atom + + + + A cell of the inner of the three germ layers of the embryo. + FMA:72555 + endoderm cell + CL:0000223 + endodermal cell - - - - main group elements - IUPAC - - - - - - Hauptgruppenelement - ChEBI - - - - - Hauptgruppenelemente - ChEBI - - - - - main group element - ChEBI - - + - - - - chebi_ontology - oxoacids of sulfur - sulfur oxoacids - CHEBI:33402 - - sulfur oxoacid + + + A cell with more than one nucleus. + AEO:0000203 + WBbt:0008074 + syncitium + syncytial cell + syncytium + CL:0000228 + multinucleate cell - - - - oxoacids of sulfur - ChEBI - - - - - sulfur oxoacids - ChEBI - - + - - - + + + + - - + + - chebi_ontology - pnictogen oxoacids - CHEBI:33408 - - pnictogen oxoacid + A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen. + BTO:0000424 + CALOHA:TS-0290 + FMA:81100 + RBC + red blood cell + CL:0000232 + erythrocyte - - - - pnictogen oxoacids - ChEBI - - + - - - - sulfur oxoacid derivative - chebi_ontology - sulfur oxoacid derivatives - CHEBI:33424 - - sulfur oxoacid derivative + + + MESH:D005057 + CL:0000255 + eukaryotic cell - - - - sulfur oxoacid derivative - ChEBI - - - - - sulfur oxoacid derivatives - ChEBI - - + - - - - A pnictogen oxoacid which contains phosphorus and oxygen, at least one hydrogen atom bound to oxygen, and forms an ion by the loss of one or more protons. - phosphorus oxoacid - chebi_ontology - Oxosaeure des Phosphors - oxoacids of phosphorus - phosphorus oxoacids - CHEBI:33457 - - phosphorus oxoacid + + + CL:0000287 + eye photoreceptor cell - - - - phosphorus oxoacid - ChEBI - - - - - Oxosaeure des Phosphors - ChEBI - - - - - oxoacids of phosphorus - ChEBI - - - - - phosphorus oxoacids - ChEBI - - + - - - - pnictogen oxoanion - chebi_ontology - pnictogen oxoanions - CHEBI:33459 - - pnictogen oxoanion + + + A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism. + CL:0000293 + structural cell - - - - pnictogen oxoanion - ChEBI - - - - - pnictogen oxoanions - ChEBI - - + - - - - - phosphorus oxoanion - chebi_ontology - oxoanions of phosphorus - phosphorus oxoanions - CHEBI:33461 - - phosphorus oxoanion + + + Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid. + BTO:0003687 + FMA:62511 + serous cell + CL:0000313 + serous secreting cell - - - - phosphorus oxoanion - ChEBI - - - - - oxoanions of phosphorus - ChEBI - - - - - phosphorus oxoanions - ChEBI - - + - - - - sulfur oxoanion - chebi_ontology - oxoanions of sulfur - sulfur oxoanions - CHEBI:33482 - - sulfur oxoanion + + + BTO:0003689 + mucous cell + CL:0000319 + mucus secreting cell - - - - sulfur oxoanion - ChEBI - - - - - oxoanions of sulfur - ChEBI - - - - - sulfur oxoanions - ChEBI - - + - - - - - - - - - chalcogen oxoacid - chebi_ontology - chalcogen oxoacids - CHEBI:33484 - - chalcogen oxoacid + + + A cell that is specialised to accumulate a particular substance(s). + CL:0000325 + + stuff accumulating cell - - - - chalcogen oxoacid - ChEBI - - - - - chalcogen oxoacids - ChEBI - - + - - - chalcogen oxoanion - chebi_ontology - chalcogen oxoanions - CHEBI:33485 - - chalcogen oxoanion + + + + CL:0000327 + extracellular matrix secreting cell - - - - chalcogen oxoanion - ChEBI - - - - - chalcogen oxoanions - ChEBI - - + - - - chebi_ontology - alkali metal cations - CHEBI:33504 - - alkali metal cation + + + + CL:0000329 + oxygen accumulating cell - - - - alkali metal cations - ChEBI - - + - - - An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity. - CHEBI:25217 - CHEBI:6788 - KEGG:C00050 - PMID:21784043 - Wikipedia:Metal - chebi_ontology - elemental metal - elemental metals - metal element - metal elements - metals - CHEBI:33521 - - metal atom + + + + + + + + + + + A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. + FMA:86667 + CL:0000333 + migratory neural crest cell + + + + + + + + + A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors. + CL:0000335 + mesenchyme condensation cell - - - - PMID:21784043 - Europe PMC - - - - - elemental metal - ChEBI - - - - - elemental metals - ChEBI - - - - - metal element - ChEBI - - - - - metal elements - ChEBI - - - - - metals - ChEBI - - + - - + + + - - + + - An amino-acid anion obtained by deprotonation of any alpha-amino acid. - alpha-amino-acid anion - chebi_ontology - alpha-amino acid anions - alpha-amino-acid anions - CHEBI:33558 - - alpha-amino-acid anion + A cell of the sclera of the eye. + CL:0000347 + scleral cell - - - - alpha-amino-acid anion - ChEBI - - - - - alpha-amino acid anions - ChEBI - - - - - alpha-amino-acid anions - ChEBI - - + - - - chebi_ontology - s-block element - s-block elements - CHEBI:33559 - - s-block element atom + + + + + CL:0000349 + extraembryonic cell - - - - s-block element - ChEBI - - - - - s-block elements - ChEBI - - + - - - Any main group element atom belonging to the p-block of the periodic table. - chebi_ontology - p-block element - p-block elements - CHEBI:33560 - - p-block element atom + + + A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface. + FMA:83028 + trophoblastic cell + CL:0000351 + trophoblast cell - - - - p-block element - ChEBI - - - - - p-block elements - ChEBI - - + - - - Any compound containing an o-diphenol component. - 0 - C6H2O2R4 - 106.079 - 106.00548 - OC1=C(O)C(*)=C(*)C(*)=C1* - CHEBI:134187 - CHEBI:13628 - CHEBI:18862 - KEGG:C15571 - chebi_ontology - 1,2-benzenediols - a catechol - benzene-1,2-diols - CHEBI:33566 - - catechols + + + A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation. + CL:0000352 + epiblast cell - - - - 1,2-benzenediols - ChEBI - - - - - a catechol - UniProt - - - - - benzene-1,2-diols - ChEBI - - + - - - - 4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. - 0 - C8H9NO2R2 - 151.163 - 151.06333 - CHEBI:23056 - CHEBI:3468 - KEGG:C02012 - Catecholamine - catecholamines - chebi_ontology - catecholamines - CHEBI:33567 - - catecholamine + + + An undifferentiated cell produced by early cleavages of the fertilized egg (zygote). + BTO:0001473 + FMA:72551 + blastomere + CL:0000353 + blastoderm cell - - - - Catecholamine - KEGG_COMPOUND - - - - - catecholamines - IUPAC - - - - - - catecholamines - ChEBI - - + - - - - - - - - - - - - - - - A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted. - 0 - C8H11NO3 - InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 - SFLSHLFXELFNJZ-UHFFFAOYSA-N - 169.17788 - 169.07389 - NCC(O)c1ccc(O)c(O)c1 - Beilstein:2210994 - CAS:138-65-8 - Gmelin:863925 - LINCS:LSM-5181 - 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol - chebi_ontology - noradrenalina - norepinephrine - CHEBI:33569 - - noradrenaline + + + + A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell. + FMA:86767 + CL:0000355 + Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo. + multi-potent skeletal muscle stem cell - - - - Beilstein:2210994 - Beilstein - - - - - CAS:138-65-8 - ChemIDplus - - - - - CAS:138-65-8 - NIST Chemistry WebBook - - - - - Gmelin:863925 - Gmelin - - - - - 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol - IUPAC - - - - - - noradrenalina - ChEBI - - - - - norepinephrine - ChEBI - - + - - - CHEBI:22705 - CHEBI:22711 - chebi_ontology - CHEBI:33570 - - benzenediols + + + + Diploid cell produced by the fusion of sperm cell nucleus and egg cell. + zygote + BTO:0000854 + EHDAA2:0004546 + FMA:72395 + CL:0000365 + animal zygote - + - - - - - - - - - The S-enantiomer of noradrenaline. - 0 - C8H11NO3 - InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m1/s1 - SFLSHLFXELFNJZ-MRVPVSSYSA-N - 169.17788 - 169.07389 - NC[C@@H](O)c1ccc(O)c(O)c1 - Beilstein:2937999 - LINCS:LSM-37072 - Reaxys:2937999 - 4-[(1S)-2-amino-1-hydroxyethyl]benzene-1,2-diol - chebi_ontology - CHEBI:33571 - - (S)-noradrenaline + + + A cell whose function is determined by its response to an electric signal. + CL:0000393 + electrically responsive cell - - - - Beilstein:2937999 - Beilstein - - - - - Reaxys:2937999 - Reaxys - - - - - 4-[(1S)-2-amino-1-hydroxyethyl]benzene-1,2-diol - IUPAC - - - + - - - - - - - - - - - - - - - - - A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid. - 0 - CHO2R - 45.01740 - 44.99765 - OC([*])=O - CHEBI:13428 - CHEBI:13627 - CHEBI:23027 - PMID:17147560 - PMID:18433345 - Wikipedia:Carboxylic_acid - carboxylic acid - carboxylic acids - chebi_ontology - Carbonsaeure - Carbonsaeuren - Karbonsaeure - RC(=O)OH - acide carboxylique - acides carboxyliques - acido carboxilico - acidos carboxilicos - CHEBI:33575 - - carboxylic acid + + + + + CL:0000402 + CNS interneuron - - - - PMID:17147560 - Europe PMC - - - - - PMID:18433345 - Europe PMC - - - - - carboxylic acid - IUPAC - - - - - - carboxylic acids - IUPAC - - - - - - Carbonsaeure - ChEBI - - - - - Carbonsaeuren - ChEBI - - - - - Karbonsaeure - ChEBI - - - - - RC(=O)OH - IUPAC - - - - - acide carboxylique - IUPAC - - - - - acides carboxyliques - IUPAC - - - - - acido carboxilico - IUPAC - - - - - acidos carboxilicos - IUPAC - - + - - - - - - - - - A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table. - chebi_ontology - main group compounds - main group molecular entities - CHEBI:33579 - - main group molecular entity + + + A cell that initiates an electrical signal and passes that signal to another cell. + CL:0000404 + electrically signaling cell - - - - main group compounds - ChEBI - - - - - main group molecular entities - ChEBI - - + - - - - - - - - - carbon group molecular entity - chebi_ontology - carbon group molecular entities - CHEBI:33582 - - carbon group molecular entity + + + A cell whose nucleus, or nuclei, each contain more than two haploid genomes. + CL:0000412 + polyploid cell - - - - carbon group molecular entity - ChEBI - - - - - carbon group molecular entities - ChEBI - - + - - - Any molecule that consists of a series of atoms joined together to form a ring. - Wikipedia:Cyclic_compound - chebi_ontology - cyclic compounds - CHEBI:33595 - - cyclic compound + + + CL:0000417 + endopolyploid cell - - - - cyclic compounds - ChEBI - - + - - + + + CL:0000447 + carbohydrate secreting cell + + + + + + + + + CL:0000457 + biogenic amine secreting cell + + + + + + + + + A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme. + noradrenaline secreting cell + norepinephrin secreting cell + norepinephrine secreting cell + CL:0000459 + noradrenergic cell + + + + + + + + + - - + + - chebi_ontology - hydrogen compounds - hydrogen molecular entities - CHEBI:33608 - - hydrogen molecular entity + A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere. + BTO:0002064 + FMA:83624 + CL:0000499 + stromal cell - - - - hydrogen compounds - ChEBI - - - - - hydrogen molecular entities - ChEBI - - + - - - chebi_ontology - polycyclic compounds - CHEBI:33635 - - polycyclic compound + + + + A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin. + FMA:62935 + D cell + CL:0000502 + type D enteroendocrine cell - - - - polycyclic compounds - ChEBI - - + - - - A molecule that features two fused rings. - chebi_ontology - bicyclic compounds - CHEBI:33636 - - bicyclic compound + + + An endorphine cell that secretes enkephalin. + CL:0000506 + enkephalin secreting cell - - - - bicyclic compounds - ChEBI - - + - - - A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character. - aromatic compounds - aromatic molecular entity - chebi_ontology - aromatics - aromatische Verbindungen - CHEBI:33655 - - aromatic compound + + + A peptide hormone secreting cell that secretes endorphin. + CL:0000507 + endorphin secreting cell - - - - aromatic compounds - IUPAC - - - - - - aromatic molecular entity - IUPAC - - - - - - aromatics - ChEBI - - - - - aromatische Verbindungen - ChEBI - - + - - - - chebi_ontology - organic aromatic compounds - CHEBI:33659 - - organic aromatic compound + + + + + + An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli. + BTO:0004108 + FMA:67609 + G cell + CL:0000508 + type G enteroendocrine cell - - - - organic aromatic compounds - ChEBI - - + - - - - A polycyclic compound in which at least one of the rings contains at least one non-carbon atom. - heteropolycyclic compounds - chebi_ontology - polyheterocyclic compounds - CHEBI:33671 - - heteropolycyclic compound + + + A peptide hormone secreting cell that secretes gastrin. + CL:0000509 + gastrin secreting cell - - - - heteropolycyclic compounds - IUPAC - - - - - - polyheterocyclic compounds - ChEBI - - + - - - - A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom. - heterobicyclic compounds - chebi_ontology - CHEBI:33672 - - heterobicyclic compound + + + + A precursor cell destined to differentiate into cardiac muscle cell. + CL:0000714 + FMA:84797 + cardiac muscle progenitor cell + cardiomyocyte progenitor cell + CL:0000513 + cardiac muscle myoblast - - - - heterobicyclic compounds - IUPAC - - - + - - - - - - - - - An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element. - s-block molecular entity - chebi_ontology - s-block compounds - s-block molecular entities - CHEBI:33674 - - s-block molecular entity + + + A precursor cell destined to differentiate into smooth muscle myocytes. + FMA:84798 + myoblast, smooth muscle + satellite cell + CL:0000514 + smooth muscle myoblast - - - - s-block molecular entity - ChEBI - - - - - s-block compounds - ChEBI - - - - - s-block molecular entities - ChEBI - - + - - + + + - - + + - A main group molecular entity that contains one or more atoms of a p-block element. - chebi_ontology - p-block compounds - p-block molecular entities - p-block molecular entitiy - CHEBI:33675 - - p-block molecular entity + A myoblast that differentiates into skeletal muscle fibers. + FMA:84799 + skeletal myoblast + CL:0000515 + skeletal muscle myoblast - - - - p-block compounds - ChEBI - - - - - p-block molecular entities - ChEBI - - - - - p-block molecular entitiy - ChEBI - - + - - - - Hydrides are chemical compounds of hydrogen with other chemical elements. - chebi_ontology - CHEBI:33692 - - hydrides + + + A neuron which conveys sensory information centrally from the periphery. + FMA:87653 + input neuron + CL:0000526 + afferent neuron - + - - - oxygen hydride - chebi_ontology - hydrides of oxygen - oxygen hydrides - CHEBI:33693 - - oxygen hydride + + + A neuron which sends impulses peripherally to activate muscles or secretory cells. + output neuron + CL:0000527 + efferent neuron - - - - oxygen hydride - ChEBI - - - - - hydrides of oxygen - ChEBI - - - - - oxygen hydrides - ChEBI - - + - - - - A macromolecule formed by a living organism. - biopolymer - chebi_ontology - Biopolymere - biomacromolecules - biopolymers - CHEBI:33694 - - biomacromolecule + + + CL:0000530 + primary neuron - - - - biopolymer - IUPAC - - - - - - Biopolymere - ChEBI - - - - - biomacromolecules - ChEBI - - - - - biopolymers - ChEBI - - + - - - chebi_ontology - genetically encoded biomacromolecules - genetically encoded biopolymers - information biomacromolecules - information biopolymers - information macromolecule - information macromolecules - CHEBI:33695 - - information biomacromolecule + + + + + + + + + + + + CL:0000531 + primary sensory neuron + + + + + + + + + + + + The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. + BTO:0000938 + CALOHA:TS-0683 + FBbt:00005106 + FMA:54527 + VHOG:0001483 + WBbt:0003679 + nerve cell + CL:0000540 + These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. + neuron - - - - genetically encoded biomacromolecules - ChEBI - - - - - genetically encoded biopolymers - ChEBI - - - - - information biomacromolecules - ChEBI - - - - - information biopolymers - ChEBI - - - - - information macromolecule - ChEBI - - - - - information macromolecules - ChEBI - - + - - + + + - + - + - A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid. - nucleic acids - chebi_ontology - NA - Nukleinsaeure - Nukleinsaeuren - acide nucleique - acides nucleiques - acido nucleico - acidos nucleicos - CHEBI:33696 - - nucleic acid + + + + + + + An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers. + FMA:83518 + rubriblast + pronormoblast + CL:0000547 + proerythroblast + + + + + + + + + CL:0000548 + + animal cell - - - - nucleic acids - IUPAC - - - - - - NA - ChEBI - - - - - Nukleinsaeure - ChEBI - - - - - Nukleinsaeuren - ChEBI - - - - - acide nucleique - ChEBI - - - - - acides nucleiques - ChEBI - - - - - acido nucleico - ChEBI - - - - - acidos nucleicos - ChEBI - - + - - + + - + + A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers. + FMA:83505 + basophilic normoblast + early erythroblast + early normoblast + prorubricyte + CL:0000549 + basophilic erythroblast + + + + + + + + - + - High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins. - CAS:63231-63-0 - ribonucleic acid - ribonucleic acids - chebi_ontology - RNA - RNS - Ribonukleinsaeure - pentosenucleic acids - ribonucleic acids - ribose nucleic acid - yeast nucleic acid - CHEBI:33697 - - ribonucleic acid + + + + + + + A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers. + FMA:83506 + intermediate erythroblast + intermediate normoblast + polychromatic erythroblast + polychromatic normoblast + polychromatophilic normoblast + rubricyte + CL:0000550 + polychromatophilic erythroblast - - - - CAS:63231-63-0 - ChemIDplus - - - - - ribonucleic acid - IUPAC - - - - - ribonucleic acids - IUPAC - - - - - - RNA - IUPAC - - - - - RNA - UniProt - - - - - RNS - ChEBI - - - - - Ribonukleinsaeure - ChEBI - - - - - pentosenucleic acids - ChemIDplus - - - - - ribonucleic acids - ChEBI - - - - - ribose nucleic acid - ChEBI - - - - - yeast nucleic acid - ChEBI - - + - - - chebi_ontology - canonical amino-acid residue - canonical amino-acid residues - common amino acid residues - proteinogenic amino-acid residues - standard amino acid residues - standard amino-acid residues - CHEBI:33700 - - proteinogenic amino-acid residue - - - - - canonical amino-acid residue - ChEBI - - - - - canonical amino-acid residues - ChEBI - - - - - common amino acid residues - ChEBI - - - - - proteinogenic amino-acid residues - ChEBI - - - - - standard amino acid residues - ChEBI - - - - - standard amino-acid residues - ChEBI - - - - - - - - - - A cation consisting of more than one atom. - chebi_ontology - polyatomic cations - CHEBI:33702 - - polyatomic cation - - - - - polyatomic cations - ChEBI - - - - - - - - + + - - + + - - + + - An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group. - 0 - C2H4NO2R - 74.05870 - 74.02420 - NC([*])C(O)=O - CHEBI:10208 - CHEBI:13779 - CHEBI:22442 - CHEBI:2642 - KEGG:C00045 - KEGG:C05167 - alpha-amino acid - chebi_ontology - Amino acid - Amino acids - alpha-amino acids - alpha-amino carboxylic acids - CHEBI:33704 - - alpha-amino acid + The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated. + FMA:84646 + acidophilic erythroblast + eosinophilic erythroblast + late erythoblast + orthochromatic normoblast + pyknotic eto enrythroblast + CL:0000552 + orthochromatic erythroblast - - - - alpha-amino acid - IUPAC - - - - - - Amino acid - KEGG_COMPOUND - - - - - Amino acids - KEGG_COMPOUND - - - - - alpha-amino acids - ChEBI - - - - - alpha-amino acids - JCBN - - - - - alpha-amino carboxylic acids - IUPAC - - + - - + + - - + + - When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue. - amino-acid residue - chebi_ontology - amino acid residue - amino-acid residues - CHEBI:33708 - - amino-acid residue + An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds. + BTO:0001173 + CALOHA:TS-0864 + MESH:D012156 + CL:0000558 + reticulocyte - - - - amino-acid residue - IUPAC - - - - - - amino acid residue - ChEBI - - - - - amino-acid residues - JCBN - - + - - - + + + - - + + - A carboxylic acid containing one or more amino groups. - CHEBI:13815 - CHEBI:22477 - Wikipedia:Amino_acid - chebi_ontology - Aminocarbonsaeure - Aminokarbonsaeure - Aminosaeure - amino acids - CHEBI:33709 - - amino acid + A mesenchymal stem cell capable of developing into blood vessel endothelium. + angioblast + chondroplast + CL:0000566 + These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive. + angioblastic mesenchymal cell - - - - Aminocarbonsaeure - ChEBI - - - - - Aminokarbonsaeure - ChEBI - - - - - Aminosaeure - ChEBI - - - - - amino acids - ChEBI - - + - - + + + - - + + - chebi_ontology - alpha-amino-acid residues - CHEBI:33710 - - alpha-amino-acid residue + One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision. + BTO:0001036 + CALOHA:TS-0866 + FMA:67748 + CL:0000573 + retinal cone cell - - - - alpha-amino-acid residues - ChEBI - - + - - - - - - - - - - carbohydrate acid - chebi_ontology - carbohydrate acids - CHEBI:33720 - - carbohydrate acid + + + The reproductive cell in multicellular organisms. + BTO:0000535 + VHOG:0001534 + WBbt:0006796 + CL:0000586 + germ cell + + + + + + + + + A steroid hormone secreting cell that secretes androgen. + CL:0000593 + androgen secreting cell - - - - carbohydrate acid - ChEBI - - - - - carbohydrate acids - ChEBI - - + - - + + + - - + + - carbohydrate acid anion - chebi_ontology - carbohydrate acid anions - CHEBI:33721 - - carbohydrate acid anion + One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision. + BTO:0001024 + CALOHA:TS-0870 + FMA:67747 + CL:0000604 + retinal rod cell - - - - carbohydrate acid anion - ChEBI - - - - - carbohydrate acid anions - ChEBI - - + - - - chebi_ontology - canonical nucleoside residues - common nucleoside residues - nucleoside residue - standard nucleoside residues - CHEBI:33791 - - canonical nucleoside residue + + + + A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus). + FMA:83625 + MESH:D061354 + acinic cell + acinous cell + CL:0000622 + acinar cell - - - - canonical nucleoside residues - ChEBI - - - - - common nucleoside residues - CBN - - - - - nucleoside residue - CBN - - - - - standard nucleoside residues - ChEBI - - + - - - chebi_ontology - N - Nuc - canonical ribonucleoside residues - common ribonucleoside residue - common ribonucleoside residues - standard ribonucleoside residues - CHEBI:33792 - - canonical ribonucleoside residue + + + A cell whose primary function is to support other cell types. + BTO:0002315 + supportive cell + CL:0000630 + supporting cell - - - - N - CBN - - - - - Nuc - CBN - - - - - canonical ribonucleoside residues - ChEBI - - - - - common ribonucleoside residue - CBN - - - - - common ribonucleoside residues - CBN - - - - - standard ribonucleoside residues - ChEBI - - + - - - chebi_ontology - canonical deoxyribonucleoside residues - common 2'-deoxyribonucleoside residue - common 2'-deoxyribonucleoside residues - dN - dNuc - standard deoxyribonucleoside residues - CHEBI:33793 - - canonical deoxyribonucleoside residue + + + An extracellular matrix secreting cell that secretes collagen. + CL:0000667 + collagen secreting cell - - - - canonical deoxyribonucleoside residues - ChEBI - - - - - common 2'-deoxyribonucleoside residue - CBN - - - - - common 2'-deoxyribonucleoside residues - CBN - - - - - dN - CBN - - - - - dNuc - CBN - - - - - standard deoxyribonucleoside residues - ChEBI - - + - - - - An organic compound having at least one hydroxy group attached to a carbon atom. - CHEBI:64710 - hydroxy compounds - chebi_ontology - organic alcohol - organic hydroxy compounds - CHEBI:33822 - - organic hydroxy compound + + + + + + + + + + + A non-terminally differentiated cell that is capable of developing into a muscle cell. + CL:0000680 + muscle precursor cell - - - - hydroxy compounds - IUPAC - - - - - - organic alcohol - ChEBI - - - - - organic hydroxy compounds - ChEBI - - + - - - - Any organic molecule that consists of atoms connected in the form of a ring. - chebi_ontology - organic cyclic compounds - CHEBI:33832 - - organic cyclic compound + + + + A cell that stores and secretes pancreatic polypeptide hormone. + FMA:62938 + FMA:83409 + type F enteroendocrine cell + CL:0000696 + PP cell - - - - organic cyclic compounds - ChEBI - - + - - - - A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2). - heteroarenes - chebi_ontology - hetarenes - CHEBI:33833 - - heteroarene + + + + + + + + + + + + + + + + + + + + + Epithelial cells derived from neural plate and neural crest. + neuroepithelial cell + BTO:0004301 + FMA:70557 + CL:0000710 + The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). + neurecto-epithelial cell - - - - heteroarenes - IUPAC - - - - - - hetarenes - IUPAC - - + - - - Conjugated protein is a protein that contains a non-peptide component, usually in stoichiometric proportion. - COMe:PRX000001 - conjugated proteins - chebi_ontology - complex protein - CHEBI:33837 - - conjugated protein + + + + A stem cell that can give rise to cell types of the body other than those of the germ-line. + CALOHA:TS-2086 + FMA:63368 + MESH:D053687 + CL:0000723 + somatic stem cell - - - - conjugated proteins - IUPAC - - - - - - complex protein - COMe - - + - - - A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - Wikipedia:Macromolecule - macromolecule - chebi_ontology - macromolecules - polymer - polymer molecule - polymers - CHEBI:33839 - - macromolecule + + + + Muscle cell which has as its direct parts myofilaments organized into sarcomeres. + BTO:0002916 + CALOHA:TS-2157 + FMA:86936 + CL:0000737 + striated muscle cell - - - - macromolecule - IUPAC - - - - - - macromolecules - ChEBI - - - - - polymer - ChEBI - - - - - polymer molecule - IUPAC - - - - - polymers - ChEBI - - + - - - - Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring. - 0 - C6HOR5 - 89.072 - 89.00274 - C1(=C(C(=C(C(=C1*)*)*)*)*)O - CHEBI:13664 - CHEBI:13825 - CHEBI:25969 - CHEBI:2857 - KEGG:C15584 - MetaCyc:Phenols - Wikipedia:Phenols - phenols - chebi_ontology - Aryl alcohol - a phenol - arenols - CHEBI:33853 - - phenols + + + The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve. + BTO:0001800 + FMA:67765 + MESH:D012165 + RGC + gangliocyte + ganglion cell of retina + CL:0000740 + retinal ganglion cell - - - - phenols - IUPAC - - - - - - Aryl alcohol - KEGG_COMPOUND - - - - - a phenol - UniProt - - - - - arenols - IUPAC - - + - - - A substance used in a chemical reaction to detect, measure, examine, or produce other substances. - reagent - chebi_ontology - reactif - reactivo - reagents - CHEBI:33893 - - reagent + + + + + + + + + + Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei. + FMA:83808 + cardiocyte + BTO:0001539 + CALOHA:TS-0115 + FMA:14067 + MESH:D032383 + cardiac muscle fiber + cardiac myocyte + cardiomyocyte + heart muscle cell + CL:0000746 + This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction. + cardiac muscle cell - - - - reagent - IUPAC - - - - - - reactif - IUPAC - - - - - reactivo - IUPAC - - - - - reagents - ChEBI - - + - - - - A hexose with a (potential) aldehyde group at one end. - CHEBI:2558 - aldohexose - chebi_ontology - aldohexoses - CHEBI:33917 - - aldohexose + + + + + + + + + + + + + + + + + + + + + A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. + BTO:0001441 + CALOHA:TS-0647 + MESH:D022423 + CL:0000763 + myeloid cell - - - - aldohexose - ChEBI - - - - - aldohexoses - ChEBI - - + - - - Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals. - chebi_ontology - macronutrients - CHEBI:33937 - - macronutrient + + + A immature or mature cell in the lineage leading to and including erythrocytes. + CL:0002156 + CALOHA:TS-0290 + FMA:62845 + FMA:83516 + erythropoietic cell + CL:0000764 + Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes. + erythroid lineage cell - - - - macronutrients - ChEBI - - + - - - - - - - - - + + + - - + + - An ammonium ion that is the conjugate acid of serotonin; major species at pH 7.3. - +1 - C10H13N2O - InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 - QZAYGJVTTNCVMB-UHFFFAOYSA-O - 177.22250 - 177.10224 - [NH3+]CCc1c[nH]c2ccc(O)cc12 - 2-(5-hydroxy-1H-indol-3-yl)ethanaminium - chebi_ontology - serotonin - serotonin cation - CHEBI:350546 - - serotonin(1+) - - - - - 2-(5-hydroxy-1H-indol-3-yl)ethanaminium - IUPAC - - - - - - serotonin - UniProt - - - - - serotonin cation - ChEBI - - - - - - - - - - chebi_ontology - nitrogen hydrides - CHEBI:35106 - - nitrogen hydride + A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers. + BTO:0001571 + CALOHA:TS-0289 + FMA:83504 + MESH:D004900 + normoblast + CL:0000765 + erythroblast - - - - nitrogen hydrides - ChEBI - - + - - - Saturated acyclic nitrogen hydrides having the general formula NnHn+2. - chebi_ontology - azanes - CHEBI:35107 - - azane + + + + + + + + + + + A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans. + BTO:0000725 + CALOHA:TS-0448 + MPP + hemopoietic progenitor cell + CL:0000837 + Markers differ between mouse and human. + hematopoietic multipotent progenitor cell - - - - azanes - ChEBI - - + - - - A substance that diminishes the rate of a chemical reaction. - inhibitor - chebi_ontology - inhibidor - inhibiteur - inhibitors - CHEBI:35222 - - inhibitor + + + + A progenitor cell restricted to the myeloid lineage. + myeloid progenitor cell + BTO:0004730 + CALOHA:TS-2099 + FMA:70339 + CL:0000839 + Note that this is a class of cell types, not an identified single cell type. + myeloid lineage restricted progenitor cell - - - - inhibitor - IUPAC - - - - - - inhibidor - ChEBI - - - - - inhibiteur - ChEBI - - - - - inhibitors - ChEBI - - + - - - A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction. - catalyst - chebi_ontology - Katalysator - catalizador - catalyseur - CHEBI:35223 - - catalyst + + + + A cell of a hematopoietic lineage. + BTO:0000574 + CALOHA:TS-2017 + FMA:70366 + FMA:83598 + haematopoietic cell + haemopoietic cell + hemopoietic cell + CL:0000988 + hematopoietic cell - - - - catalyst - IUPAC - - - - - - Katalysator - ChEBI - - - - - catalizador - ChEBI - - - - - catalyseur - ChEBI - - + - - - The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group. - amino acid zwitterion - chebi_ontology - CHEBI:35238 - - amino acid zwitterion + + + + A connective tissue cell found in bone. + adiehl + 2011-11-16T04:28:16Z + CL:0001035 + bone cell - - - - amino acid zwitterion - ChEBI - - + - - - + + + - - + + - A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups. - +1 - NR4 - 14.00670 - 14.00307 - [*][N+]([*])([*])[*] - CHEBI:26470 - CHEBI:8693 - KEGG:C06703 - quaternary ammonium ion - chebi_ontology - Quaternary amine - a quaternary ammonium - quaternary ammonium ions - CHEBI:35267 - - quaternary ammonium ion + + A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells. + tmeehan + 2010-01-06T03:43:20Z + CL:0002031 + hematopoietic lineage restricted progenitor cell - - - - quaternary ammonium ion - IUPAC - - - - - - Quaternary amine - KEGG_COMPOUND - - - - - a quaternary ammonium - UniProt - - - - - quaternary ammonium ions - ChEBI - - + - - - + + + - - + + - A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc). - chebi_ontology - ammonium ion derivatives - azanium ion derivative - azanium ion derivatives - CHEBI:35274 - - ammonium ion derivative - - - - - ammonium ion derivatives - ChEBI - - - - - azanium ion derivative - ChEBI - - - - - azanium ion derivatives - ChEBI - - - - - - - - - A choline ester formed from choline and a carboxylic acid. - +1 - C6H13NO2R - 131.17290 - 131.09463 - C[N+](C)(C)CCOC([*])=O - CHEBI:13245 - CHEBI:22227 - CHEBI:2463 - KEGG:C01777 - chebi_ontology - acylcholines - an acylcholine - CHEBI:35287 - - acylcholine + A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. + tmeehan + 2010-01-06T03:43:27Z + CL:0002032 + This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). + hematopoietic oligopotent progenitor cell - - - - acylcholines - ChEBI - - - - - an acylcholine - UniProt - - + - - - - Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene. - 0 - C19H31R - 259.450 - 259.24258 - C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CCCC4)C - CHEBI:13687 - CHEBI:26768 - CHEBI:9263 - KEGG:C00377 - MetaCyc:Steroids - Steroid - steroids - chebi_ontology - a steroid - CHEBI:35341 - - steroid + + + + A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules. + tmeehan + 2010-06-24T03:16:29Z + BTO:0000028 + CALOHA:TS-0737 + FMA:63032 + acinar cell of pancreas + CL:0002064 + pancreatic acinar cell - - - - Steroid - KEGG_COMPOUND - - - - - steroids - IUPAC - - - - - - a steroid - UniProt - - + - - - - CHEBI:24748 - CHEBI:5814 - KEGG:C02159 - chebi_ontology - Hydroxysteroid - hydroxy steroids - hydroxysteroids - CHEBI:35350 - - hydroxy steroid + + + + An enteroendocrine cell that produces glucagon. + tmeehan + 2010-09-10T10:48:54Z + FMA:62939 + CL:0002067 + type A enteroendocrine cell - - - - Hydroxysteroid - KEGG_COMPOUND - - - - - hydroxy steroids - ChEBI - - - - - hydroxysteroids - ChEBI - - + - - - - Any heteroorganic entity containing at least one carbon-nitrogen bond. - organonitrogen compounds - chebi_ontology - organonitrogens - CHEBI:35352 - - organonitrogen compound + + + Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter. + tmeehan + 2010-06-28T08:36:15Z + BTO:0001032 + FMA:14146 + Purkinje cell fiber + Purkinje muscle cell + myocytus conducens cardiacus + CL:0002068 + Purkinje myocyte - - - - organonitrogen compounds - IUPAC - - - - - - organonitrogens - ChEBI - - + - - - Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group. - CHEBI:25407 - CHEBI:6984 - KEGG:C06698 - Monosaccharide - monosaccharides - chebi_ontology - Monosaccharid - Monosacharid - monosacarido - monosacaridos - CHEBI:35381 - - monosaccharide + + + A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery. + tmeehan + 2010-06-29T11:41:37Z + pacemaker cell + BTO:0004190 + FMA:67101 + P cell + cardiac pacemaker cell + myocytus nodalis + CL:0002072 + nodal myocyte - - - - Monosaccharide - KEGG_COMPOUND - - - - - monosaccharides - IUPAC - - - - - - Monosaccharid - ChEBI - - - - - Monosacharid - ChEBI - - - - - monosacarido - ChEBI - - - - - monosacaridos - IUPAC - - + - - - - An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen. - CHEBI:33274 - CHEBI:33436 - oxoanion - chebi_ontology - oxoacid anions - oxoanions - CHEBI:35406 - - oxoanion + + + Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes. + tmeehan + 2010-06-29T02:39:32Z + FMA:67142 + CL:0002073 + transitional myocyte - - - - oxoanion - ChEBI - - - - - oxoacid anions - ChEBI - - - - - oxoanions - ChEBI - - + - - - - A substance that reduces or suppresses inflammation. - chebi_ontology - anti-inflammatory drugs - antiinflammatory agent - antiinflammatory drug - antiinflammatory drugs - CHEBI:35472 - - anti-inflammatory drug + + + + The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides). + tmeehan + 2010-06-29T11:50:47Z + FMA:67111 + CL:0002074 + myocardial endocrine cell - - - - anti-inflammatory drugs - ChEBI - - - - - antiinflammatory agent - ChEBI - - - - - antiinflammatory drug - ChEBI - - - - - antiinflammatory drugs - ChEBI - - + - - - - chebi_ontology - alkali metal salts - CHEBI:35479 - - alkali metal salt + + + + + + + + + + + An epithelial cell derived from endoderm. + tmeehan + 2010-06-29T03:38:14Z + FMA:69075 + CL:0002076 + endo-epithelial cell - - - - alkali metal salts - ChEBI - - + - - - natural product fundamental parents - chebi_ontology - CHEBI:35507 - - natural product fundamental parent + + + + + + + + + + + + + + + + + + + + + + An epithelial cell derived from ectoderm. + tmeehan + 2010-06-29T03:38:22Z + FMA:69074 + CL:0002077 + ecto-epithelial cell - - - - natural product fundamental parents - IUPAC - - - + - - - - chebi_ontology - steroid fundamental parents - CHEBI:35508 - - steroid fundamental parent + + + + + + + + + + + + + + + + + + + + + + Epithelial cell derived from mesoderm or mesenchyme. + tmeehan + 2010-06-29T03:49:14Z + FMA:69076 + epithelial mesenchymal cell + CL:0002078 + meso-epithelial cell - - - - steroid fundamental parents - ChEBI - - + - - - 0 - C24H42 - InChI=1S/C24H42/c1-5-8-17(2)20-12-13-21-19-11-10-18-9-6-7-15-23(18,3)22(19)14-16-24(20,21)4/h17-22H,5-16H2,1-4H3/t17-,18?,19+,20-,21+,22+,23+,24-/m1/s1 - QSHQKIURKJITMZ-BRPMRXRMSA-N - 330.59028 - 330.32865 - [H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4CCCC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC - cholane - chebi_ontology - CHEBI:35519 - - cholane + + + A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart. + tmeehan + 2010-07-21T01:33:38Z + FMA:67968 + CL:0002086 + specialized cardiac myocyte - - - - cholane - IUPAC - - - + - - - A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. - chebi_ontology - sympathomimetic - sympathomimetics - CHEBI:35524 - - sympathomimetic agent + + + A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells. + tmeehan + 2010-07-22T04:48:15Z + BTO:0004850 + FMA:83621 + MESH:D001854 + CL:0002092 + MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. + bone marrow cell - - - - sympathomimetic - ChEBI - - - - - sympathomimetics - ChEBI - - + - - - A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. - chebi_ontology - cardiovascular agent - cardiovascular drugs - CHEBI:35554 - - cardiovascular drug + + + + A cell in the hilum of the ovary that produces androgens. + tmeehan + 2010-08-23T11:18:18Z + FMA:18710 + hilar cell of ovary + CL:0002095 + hilus cell of ovary - - - - cardiovascular agent - ChEBI - - - - - cardiovascular drugs - ChEBI - - + - - - - An agent that selectively binds to and activates alpha-adrenergic receptors. - chebi_ontology - alpha-adrenergic agonists - alpha-adrenergic receptor agonist - alpha-adrenoceptor agonists - CHEBI:35569 - - alpha-adrenergic agonist + + + A stomal cell of the ovary + tmeehan + 2010-08-23T12:10:31Z + FMA:72299 + ovarian stromal cell + CL:0002132 + stromal cell of ovary - - - - alpha-adrenergic agonists - ChEBI - - - - - alpha-adrenergic receptor agonist - ChEBI - - - - - alpha-adrenoceptor agonists - IUPHAR - - + - - - - - A negative ion consisting solely of carbon and oxygen atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n. - carbon oxoanion - chebi_ontology - carbon oxoanions - oxocarbon anion - oxocarbon anions - CHEBI:35604 - - carbon oxoanion + + + An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels. + tmeehan + 2010-08-24T02:06:40Z + BTO:0001854 + CALOHA:TS-1106 + FMA:67755 + vascular endothelial cell + cubodial endothelial cell of vascular tree + CL:0002139 + These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive. + endothelial cell of vascular tree - - - - carbon oxoanion - ChEBI - - - - - carbon oxoanions - ChEBI - - - - - oxocarbon anion - ChEBI - - - - - oxocarbon anions - ChEBI - - + - - - - chebi_ontology - carbon oxoacids - oxoacids of carbon - CHEBI:35605 - - carbon oxoacid + + + + + + + + + + A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree. + tmeehan + 2010-08-24T03:38:29Z + FMA:70542 + CL:0002145 + ciliated columnar cell of tracheobronchial tree - - - - carbon oxoacids - ChEBI - - - - - oxoacids of carbon - ChEBI - - + - - - A drug used to cause dilation of the blood vessels. - chebi_ontology - vasodilator - vasodilator agents - CHEBI:35620 - - vasodilator agent + + + An epithelial cell found in the lining of the stomach. + tmeehan + 2010-08-25T03:22:08Z + CL:1000399 + FMA:62948 + CL:0002178 + epithelial cell of stomach - - - - vasodilator - ChEBI - - - - - vasodilator agents - ChEBI - - + - - - - - - - - - - Any carboxylic acid containing two carboxy groups. - CHEBI:23692 - CHEBI:36172 - CHEBI:4501 - KEGG:C02028 - Dicarboxylic acid - chebi_ontology - dicarboxylic acids - CHEBI:35692 - - dicarboxylic acid + + + A mucous cell in the epithelium of the stomach. + tmeehan + 2010-08-25T03:38:51Z + CL:1000404 + FMA:63464 + CL:0002180 + mucous cell of stomach - - - - Dicarboxylic acid - KEGG_COMPOUND - - - - - dicarboxylic acids - ChEBI - - + - - - - - - - - - dicarboxylic acid anion - chebi_ontology - dicarboxylic acid anions - CHEBI:35693 - - dicarboxylic acid anion + + + An epithelial cell of the tracheobronchial tree. + tmeehan + 2010-09-02T02:09:14Z + CL:1000407 + FMA:66816 + CL:0002202 + epithelial cell of tracheobronchial tree - - - - dicarboxylic acid anion - ChEBI - - - - - dicarboxylic acid anions - ChEBI - - + - - - A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter. - CHEBI:23960 - CHEBI:4859 - KEGG:C00287 - Wikipedia:Ester - Ester - chebi_ontology - esters - CHEBI:35701 - - ester + + + An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells. + tmeehan + 2010-09-02T02:53:59Z + FMA:69060 + undifferentiated columnar cell of tracheobronchial tree + CL:0002209 + intermediate epitheliocyte - - - - Ester - KEGG_COMPOUND - - - - - esters - ChEBI - - + - - - - chebi_ontology - glycosaminoglycan sulfate - glycosaminoglycan sulfates - sulfated glycosaminoglycans - CHEBI:35722 - - sulfated glycosaminoglycan + + + + A fibroblast in the bone marrow. + tmeehan + 2010-09-07T02:25:18Z + FMA:84377 + CL:0002240 + marrow fibroblast - - - - glycosaminoglycan sulfate - ChEBI - - - - - glycosaminoglycan sulfates - ChEBI - - - - - sulfated glycosaminoglycans - ChEBI - - + - - - - - chebi_ontology - carbohydrate sulfates - carbohydrate sulphates - CHEBI:35724 - - carbohydrate sulfate + + + A cell containing at least one nucleus. + tmeehan + 2010-09-07T03:32:33Z + FMA:67513 + CL:0002242 + nucleate cell - - - - carbohydrate sulfates - ChEBI - - - - - carbohydrate sulphates - ChEBI - - + - - - - - - - - - A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated. - -1 - CO2R - 44.01000 - 43.98983 - [O-]C([*])=O - CHEBI:13657 - CHEBI:25382 - CHEBI:3407 - KEGG:C00060 - chebi_ontology - Carboxylate - Monocarboxylate - a monocarboxylate - monocarboxylates - monocarboxylic acid anions - CHEBI:35757 - - monocarboxylic acid anion + + + An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus. + tmeehan + 2010-09-08T09:26:53Z + CL:0002251 + epithelial cell of alimentary canal - - - - Carboxylate - KEGG_COMPOUND - - - - - Monocarboxylate - KEGG_COMPOUND - - - - - a monocarboxylate - UniProt - - - - - monocarboxylates - ChEBI - - - - - monocarboxylic acid anions - ChEBI - - + - + - - - - - - - - - - - - - - A phosphorus oxoanion that is the conjugate base of phosphoric acid. - chebi_ontology - Pi - phosphate - phosphate ions - CHEBI:35780 - - phosphate ion + + + A cell that is part of the nervous system. + tmeehan + 2010-09-15T01:34:57Z + CALOHA:TS-2040 + FMA:70333 + CL:0002319 + neural cell - - - - Pi - ChEBI - - - - - phosphate - ChEBI - - - - - phosphate ions - ChEBI - - + - - - - pnictogen hydride - chebi_ontology - pnictogen hydrides - CHEBI:35881 - - pnictogen hydride + + + + + A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone. + tmeehan + 2010-09-15T03:01:54Z + CL:1000406 + CALOHA:TS-2096 + FMA:63875 + MESH:D003239 + CL:0002320 + connective tissue cell - - - - pnictogen hydride - ChEBI - - - - - pnictogen hydrides - ChEBI - - + - - - - A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function. - chebi_ontology - neurotransmitter agents - CHEBI:35942 - - neurotransmitter agent + + + A cell of the embryo. + tmeehan + 2010-09-15T03:39:21Z + CALOHA:TS-0263 + FMA:82840 + FMA:82841 + WBbt:0007028 + CL:0002321 + embryonic cell (metazoa) - - - - neurotransmitter agents - ChEBI - - + - - - - - - - - - CHEBI:22867 - CHEBI:50419 - LIPID_MAPS_class:LMST04 - chebi_ontology - bile acids and derivatives - cholanoids - CHEBI:36078 - - cholanoid + + + An epithelial cell of the bronchus. + tmeehan + 2010-09-20T02:00:00Z + BTO:0002922 + CL:0002328 + bronchial epithelial cell - - - - LIPID_MAPS_class:LMST04 - LIPID MAPS - - - - - bile acids and derivatives - LIPID_MAPS - - - - - cholanoids - ChEBI - - + - - + + + + + + + + + + + + + - - + + - A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome. - CHEBI:13677 - CHEBI:14911 - proteins - chebi_ontology - CHEBI:36080 - - protein + + + + + + + A fat cell derived from a neural crest cell. + tmeehan + 2010-09-20T02:25:25Z + CL:0002333 + neural crest derived fat cell - - - - proteins - IUPAC - - - + - - - - chebi_ontology - bile acid anions - CHEBI:36235 - - bile acid anion + + + An endo-epithelial cell of the respiratory tract. + tmeehan + 2010-09-23T04:38:49Z + BTO:0004533 + airway epithelial cell + CL:0002368 + respiratory epithelial cell - - - - bile acid anions - ChEBI - - + - - - A steroid acid that consists of cholane having a carboxy group in place of the methyl group at position 24. - 0 - C24H40O2 - InChI=1S/C24H40O2/c1-16(7-12-22(25)26)19-10-11-20-18-9-8-17-6-4-5-14-23(17,2)21(18)13-15-24(19,20)3/h16-21H,4-15H2,1-3H3,(H,25,26)/t16-,17?,18+,19-,20+,21+,23+,24-/m1/s1 - RPKLZQLYODPWTM-KBMWBBLPSA-N - 360.57320 - 360.30283 - [H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4CCCC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(O)=O - CAS:25312-65-6 - Patent:JP2008069152 - Reaxys:13246008 - cholan-24-oic acid - chebi_ontology - CHEBI:36237 - - cholanic acid + + + + + + + + + + + + + A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell). + tmeehan + 2010-09-24T09:44:42Z + BTO:0001268 + FMA:72300 + WBbt:0008378 + CL:0002371 + + somatic cell - - - - CAS:25312-65-6 - ChemIDplus - - - - - Reaxys:13246008 - Reaxys - - - - - cholan-24-oic acid - IUPAC - - - + - - - - 0 - C24H40O2 - InChI=1S/C24H40O2/c1-16(7-12-22(25)26)19-10-11-20-18-9-8-17-6-4-5-14-23(17,2)21(18)13-15-24(19,20)3/h16-21H,4-15H2,1-3H3,(H,25,26)/t16-,17+,18+,19-,20+,21+,23+,24-/m1/s1 - RPKLZQLYODPWTM-LVVAJZGHSA-N - 360.57320 - 360.30283 - [H][C@@]12CCCC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])CC2)[C@H](C)CCC(O)=O - Beilstein:3214794 - CAS:546-18-9 - LIPID_MAPS_instance:LMST04010441 - 5beta-cholan-24-oic acid - 5beta-cholanic acid - chebi_ontology - (5beta)-cholan-24-oic acid - (5beta,17beta)-gamma-methylandrostane-17-butanoic acid - 5beta-cholanoic acid - ursocholanic acid - CHEBI:36238 - - 5beta-cholanic acid + + + + A transversely striated, synctial muscle cell, formed by the fusion of myoblasts. + tmeehan + 2010-09-24T01:13:01Z + CL:0000369 + FBbt:00005812 + myotubule + single cell sarcomere + CL:0002372 + myotube - - - - Beilstein:3214794 - Beilstein - - - - - CAS:546-18-9 - ChemIDplus - - - - - LIPID_MAPS_instance:LMST04010441 - LIPID MAPS - - - - - 5beta-cholan-24-oic acid - IUPAC - - - - - - 5beta-cholanic acid - ChemIDplus - - - - - (5beta)-cholan-24-oic acid - ChemIDplus - - - - - (5beta,17beta)-gamma-methylandrostane-17-butanoic acid - ChemIDplus - - - - - 5beta-cholanoic acid - ChemIDplus - - - - - ursocholanic acid - ChemIDplus - - + - - - - - - - - - - Members of the class of cholanic acids based on a 5beta-cholane skeleton. - chebi_ontology - CHEBI:36248 - - 5beta-cholanic acids + + + + + A cell located in the heart, including both muscle and non muscle cells. + tmeehan + 2010-12-07T09:37:22Z + BTO:0001539 + CALOHA:TS-0115 + FMA:83808 + FMA:84791 + heart cell + CL:0002494 + From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart. + cardiocyte - + - - - - A salt of a bile acid. - chebi_ontology - bile acid salts - CHEBI:36277 - - bile acid salt + + + + A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc + tmeehan + 2010-12-07T04:03:56Z + BTO:0002441 + FMA:84639 + CL:0002503 + adventitial cell - - - - bile acid salts - ChEBI - - + - - - - CHEBI:23166 - CHEBI:23211 - chebi_ontology - CHEBI:36278 - - cholanic acids + + + + An endothelial progenitor cell that participates in angiogenesis during development. + tmeehan + 2011-02-28T04:20:39Z + CL:0002546 + See CL:0002619. + embryonic blood vessel endothelial progenitor cell - + - - A nucleus or any of its constituents in any of their energy states. - nuclear particle - chebi_ontology - CHEBI:36347 - - nuclear particle + + + tmeehan + 2011-06-21T12:29:31Z + CL:0002632 + epithelial cell of lower respiratory tract - - - - nuclear particle - IUPAC - - - + - - - - - - - - - Any molecular entity consisting of more than one atom. - chebi_ontology - polyatomic entities - CHEBI:36357 - - polyatomic entity + + + + A glandular epithelial cell that is part of the stomach. + tmeehan + 2011-07-11T01:20:35Z + CALOHA:TS-1284 + FMA:86554 + CL:0002659 + glandular cell of stomach - - - - polyatomic entities - ChEBI - - + - - - - An ion consisting of more than one atom. - chebi_ontology - polyatomic ions - CHEBI:36358 - - polyatomic ion + + + + + + + + + + A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells. + tmeehan + 2011-08-16T02:38:01Z + CL:0002672 + retinal progenitor cell - - - - polyatomic ions - ChEBI - - + - - - + + + - - + + - phosphorus oxoacid derivative - chebi_ontology - CHEBI:36359 - - phosphorus oxoacid derivative + A neuroblast derived from a neural crest cell. + tmeehan + 2011-08-22T09:24:15Z + CL:0002676 + neural crest derived neuroblast - - - - phosphorus oxoacid derivative - ChEBI - - + - - - chebi_ontology - CHEBI:36360 - - phosphorus oxoacids and derivatives + + + A CNS interneuron located in the spinal cord. + CL:0005000 + Is_a interneuron, part_of UBERON:0002240. + spinal cord interneuron - + - - - - - - - - - - Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives. - carbonyl compounds - chebi_ontology - CHEBI:36586 - - carbonyl compound + + + A ciliated epithelial cell with many cilium. + MCC + multi-ciliated cell + multiciliated cell + multiciliated epithelial cell + CL:0005012 + multi-ciliated epithelial cell - - - - carbonyl compounds - IUPAC - - - + - - + + + Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation. + CL:0005026 + hepatoblast + https://github.com/obophenotype/cell-ontology/issues/800 + + + + + + + + + Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized). + haendel + 2012-06-15T02:51:27Z + scleroblast + CL:0007001 + Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts) + skeletogenic cell + + + + + + + + + - - + + - Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element. - oxo compounds - chebi_ontology - organic oxo compounds - CHEBI:36587 - - organic oxo compound + Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells. + haendel + 2012-06-27T08:27:35Z + CL:0007004 + premigratory neural crest cell - - - - oxo compounds - IUPAC - - - - - - organic oxo compounds - ChEBI - - + - - - Compounds based on a biladiene skeleton. - chebi_ontology - CHEBI:36735 - - biladienes + + + Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells. + haendel + 2012-06-27T10:44:01Z + CL:0007009 + prechondroblast - + - - - - chalcogen hydride - chebi_ontology - chalcogen hydrides - CHEBI:36902 - - chalcogen hydride + + + Any muscle cell in which the fibers are not organised into sarcomeres. + CL:0008000 + non-striated muscle cell - - - - chalcogen hydride - ChEBI - - - - - chalcogen hydrides - ChEBI - - + - - - - chebi_ontology - inorganic ions - CHEBI:36914 - - inorganic ion + + + Any hematopoietic cell that is a precursor of some other hematopoietic cell type. + CL:0008001 + hematopoietic precursor cell - - - - inorganic ions - ChEBI - - + - - - - chebi_ontology - inorganic cations - CHEBI:36915 - - inorganic cation + + + + + + + + + + A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. + MESH:D018485 + CL:0008002 + skeletal muscle fiber + skeletal muscle fiber - - - - inorganic cations - ChEBI - - + - - - A monoatomic or polyatomic species having one or more elementary charges of the proton. - CHEBI:23058 - CHEBI:3473 - KEGG:C01373 - Cation - cation - chebi_ontology - Kation - Kationen - cationes - cations - CHEBI:36916 - - cation + + + A muscle cell that is part of some visceral muscle + FBbt:00005070 + CL:0008007 + visceral muscle cell + visceral muscle cell - - - - Cation - KEGG_COMPOUND - - - - - cation - ChEBI - - - - - cation - IUPAC - - - - - - Kation - ChEBI - - - - - Kationen - ChEBI - - - - - cationes - ChEBI - - - - - cations - ChEBI - - + - - - chalcocarbonic acid - chalcocarbonic acids - chebi_ontology - chalcocarbonic acids - CHEBI:36961 - - chalcocarbonic acid + + + + A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration. + mesenchyme cell + CL:0008019 + mesenchymal cell - - - - chalcocarbonic acid - ChEBI - - - - - chalcocarbonic acids - IUPAC - - - - - - chalcocarbonic acids - ChEBI - - + - - - - An organochalcogen compound is a compound containing at least one carbon-chalcogen bond. - organochalcogen compound - chebi_ontology - organochalcogen compounds - CHEBI:36962 - - organochalcogen compound + + + camera type eye photoreceptor cell + CL:0010009 + camera-type eye photoreceptor cell - - - - organochalcogen compound - ChEBI - - - - - organochalcogen compounds - ChEBI - - + - - - - An organochalcogen compound containing at least one carbon-oxygen bond. - PMID:17586126 - organooxygen compound - chebi_ontology - organooxygen compounds - CHEBI:36963 - - organooxygen compound + + + A zygote in a plant or an animal. + MESH:D015053 + CL:0010017 + zygote + zygote + - - - - PMID:17586126 - Europe PMC - - - - - organooxygen compound - ChEBI - - - - - organooxygen compounds - ChEBI - - + - - - - - - - - - - amino-acid anion - chebi_ontology - amino acid anions - amino-acid anions - CHEBI:37022 - - amino-acid anion + + + MESH:D032386 + CL:0010021 + cardiac myoblast - - - - amino-acid anion - ChEBI - - - - - amino acid anions - ChEBI - - - - - amino-acid anions - ChEBI - - + - - - A polysaccharide composed of glucose residues. - C12H22O11(C6H10O5)n - CHEBI:24255 - CHEBI:5392 - CAS:9037-91-6 - KEGG:C01379 - Glucan - glucan - chebi_ontology - glucans - CHEBI:37163 - - glucan + + + + A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells. + CL:0011012 + neural crest cell - - - - CAS:9037-91-6 - ChemIDplus - - - - - Glucan - KEGG_COMPOUND - - - - - glucan - IUPAC - - - - - - glucans - ChEBI - - + - - - Glycans composed of a single type of monosaccharide residue. They are named by replacing the ending '-ose' of the sugar by '-an'. - homopolysaccharide - chebi_ontology - homoglycan - homopolysaccharides - CHEBI:37164 - - homopolysaccharide + + + + + + + + + + + + + + + + + + + + + A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses. + http://orcid.org/0000-0001-5208-3432 + CL:0011026 + progenitor cell - - - - homopolysaccharide - IUPAC - - - - - - homoglycan - IUPAC - - - - - homopolysaccharides - ChEBI - - + - - - chebi_ontology - organic hydrides - CHEBI:37175 - - organic hydride + + + + A cell that, by division or terminal differentiation, can give rise to other cell types. + CL:0011115 + Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell. + precursor cell - - - - organic hydrides - ChEBI - - + - - - mononuclear parent hydrides - chebi_ontology - mononuclear hydride - mononuclear hydrides - CHEBI:37176 - - mononuclear parent hydride + + Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain. + tmeehan + 2009-12-22T04:23:25Z + eosinophilic + CL:0017502 + acidophilic cytoplasm - - - - mononuclear parent hydrides - IUPAC - - - - - - mononuclear hydride - ChEBI - - - - - mononuclear hydrides - IUPAC - - + - - - chebi_ontology - CHEBI:37246 - - elemental sodium + + Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions. + tmeehan + 2009-12-22T04:24:54Z + CL:0017503 + basophilic cytoplasm - + - - - Any of the group of polysaccharides composed of alternating units from uronic acids and glycosamines, and commonly partially esterified with sulfuric acid. - CHEBI:25425 - CHEBI:7011 - KEGG:C05114 - Mucopolysaccharide - mucopolysaccharides - chebi_ontology - Mucopolysaccharid - Mukopolysaccharid - mucopolisacarido - mucopolisacaridos - CHEBI:37395 - - mucopolysaccharide + + Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions. + tmeehan + 2009-12-28T04:25:23Z + CL:0017504 + polychromatophilic cytoplasm - - - - Mucopolysaccharide - KEGG_COMPOUND - - - - - mucopolysaccharides - IUPAC - - - - - - Mucopolysaccharid - ChEBI - - - - - Mukopolysaccharid - ChEBI - - - - - mucopolisacarido - ChEBI - - - - - mucopolisacaridos - IUPAC - - + - - - An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid). - CHEBI:13800 - CHEBI:13801 - CHEBI:22209 - CHEBI:2426 - KEGG:C00174 - Acid - acid - chebi_ontology - Saeure - Saeuren - acide - acido - acids - CHEBI:37527 - - acid + + A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell. + tmeehan + 2009-12-23T10:53:24Z + CL:0017505 + increased nucleus size - - - - Acid - KEGG_COMPOUND - - - - - acid - IUPAC - - - - - - Saeure - ChEBI - - - - - Saeuren - ChEBI - - - - - acide - IUPAC - - - - - acido - ChEBI - - - - - acids - ChEBI - - + - - - A molecular entity consisting of two or more chemical elements. - chebi_ontology - chemical compound - heteroatomic molecular entities - CHEBI:37577 - - heteroatomic molecular entity + + + trophectoderm cell + CL:1000274 + trophectodermal cell - - - - chemical compound - ChEBI - - - - - heteroatomic molecular entities - ChEBI - - + - - - - - - - - - - - An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom. - 0 - CNOR3 - 42.01680 - 41.99799 - [*]C(=O)N([*])[*] - CHEBI:35354 - CHEBI:35355 - carboxamides - chebi_ontology - carboxamides - primary carboxamide - CHEBI:37622 - - carboxamide + + + A fibroblast that is part of the areolar connective tissue. + FMA:261279 + CL:1000303 + fibroblast of areolar connective tissue - - - - carboxamides - IUPAC - - - - - - carboxamides - ChEBI - - - - - primary carboxamide - ChEBI - - + - - - - - - - - - sulfuric acid derivative - chebi_ontology - sulfuric acid derivatives - CHEBI:37826 - - sulfuric acid derivative + + + + A fibroblast that is part of the tunica adventitia of artery. + FMA:261285 + CL:1000306 + fibroblast of tunica adventitia of artery - - - - sulfuric acid derivative - ChEBI - - - - - sulfuric acid derivatives - ChEBI - - + - - + + + + A fat cell that is part of the epicardial fat. + FMA:261293 + adipocyte of epicardial fat + epicardial fat cell + CL:1000309 + epicardial adipocyte + + + + + + + + + A muscle cell that is part of the sinoatrial node. + FMA:67102 + SA nodal myocyte + SA node cardiac muscle cell + myocyte of sinoatrial node + sinoatrial node cell + sinoatrial node myocyte + sinuatrial node myocyte + CL:1000409 + myocyte of sinoatrial node + + + + + + + + + + A muscle cell that is part of the atrioventricular node. + FMA:67106 + AV nodal myocyte + AV node cardiac muscle cell + AV node cell + atrioventricular node cell + atrioventricular node myocyte + CL:1000410 + myocyte of atrioventricular node + + + + + + + + + - - + + - A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid. - carboacyl groups - carboxylic acyl group - chebi_ontology - carboxylic acyl groups - CHEBI:37838 - - carboacyl group + An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts. + FMA:86481 + epithelial cell of bile duct + CL:1000488 + cholangiocyte - - - - carboacyl groups - IUPAC - - - - - - carboxylic acyl group - IUPAC - - - - - - carboxylic acyl groups - IUPAC - - + - - - An agent that selectively binds to and activates adrenergic receptors. - chebi_ontology - adrenergic agonists - adrenergic receptor agonist - adrenoceptor agonists - adrenomimetic - adrenomimetics - CHEBI:37886 - - adrenergic agonist + + + An epithelial cell of the exocrine pancreas. + FMA:70986 + exocrine pancreas cell + CL:1001433 + epithelial cell of exocrine pancreas - - - - adrenergic agonists - ChEBI - - - - - adrenergic receptor agonist - ChEBI - - - - - adrenoceptor agonists - IUPHAR - - - - - adrenomimetic - ChEBI - - - - - adrenomimetics - ChEBI - - + - - - Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter. - chebi_ontology - adrenergic agents - adrenergic drug - adrenergic drugs - adrenergic neuron agents - adrenergics - CHEBI:37962 - - adrenergic agent + + + + + Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts. + BTO:0000028 + CALOHA:TS-1242 + exocrine pancreas glandular cell + pancreas exocrine glandular cells + CL:1001599 + pancreas exocrine glandular cell - - - - adrenergic agents - ChEBI - - - - - adrenergic drug - ChEBI - - - - - adrenergic drugs - ChEBI - - - - - adrenergic neuron agents - ChEBI - - - - - adrenergics - ChEBI - - + - - - A compound composed of two or more pyrrole units. - Beilstein:8538310 - chebi_ontology - PPys - poly(pyrrole)s - polypyrroles - CHEBI:38077 - - polypyrrole + + + + Any native cell that is part of a cardiac septum. + TermGenie + 2014-06-24T23:17:07Z + CL:2000022 + cardiac septum cell - - - - Beilstein:8538310 - Beilstein - - - - - PPys - ChEBI - - - - - poly(pyrrole)s - ChEBI - - - - - polypyrroles - ChEBI - - + - - - - Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms. - chebi_ontology - heterocyclic organonitrogen compounds - organonitrogen heterocyclic compounds - CHEBI:38101 - - organonitrogen heterocyclic compound + + + Any neuron that is part of a central nervous system. + TermGenie + 2014-06-25T01:17:43Z + CL:2000029 + central nervous system neuron - - - - heterocyclic organonitrogen compounds - ChEBI - - - - - organonitrogen heterocyclic compounds - ChEBI - - + - - - - CHEBI:25429 - CHEBI:38075 - chebi_ontology - organic heteropolycyclic compounds - CHEBI:38166 - - organic heteropolycyclic compound + + + environmental material - - - - organic heteropolycyclic compounds - ChEBI - - + - - - chebi_ontology - polycyclic heteroarenes - CHEBI:38180 - - polycyclic heteroarene + + + environmental system - - - - polycyclic heteroarenes - ChEBI - - + - - - Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons. - chebi_ontology - cholinergic agent - cholinergic drugs - cholinomimetic - CHEBI:38323 - - cholinergic drug + + + outer space - - - - cholinergic agent - ChEBI - - - - - cholinergic drugs - ChEBI - - - - - cholinomimetic - ChEBI - - + - - - Any drug that binds to and activates cholinergic receptors. - chebi_ontology - acetylcholine agonist - acetylcholine agonists - acetylcholine receptor agonist - cholinergic agonists - cholinomimetic - cholinomimetics - CHEBI:38324 - - cholinergic agonist + + + radiation - - - - acetylcholine agonist - ChEBI - - - - - acetylcholine agonists - ChEBI - - - - - acetylcholine receptor agonist - IUPHAR - - - - - cholinergic agonists - ChEBI - - - - - cholinomimetic - ChEBI - - - - - cholinomimetics - ChEBI - - + - - - Any drug that binds to and activates a muscarinic cholinergic receptor. - chebi_ontology - muscarinic acetylcholine receptor agonist - muscarinic agonists - muscarinic cholinergic agonist - muscarinic cholinergic agonists - CHEBI:38325 - - muscarinic agonist + + + energy transfer process - - - - muscarinic acetylcholine receptor agonist - ChEBI - - - - - muscarinic agonists - ChEBI - - - - - muscarinic cholinergic agonist - ChEBI - - - - - muscarinic cholinergic agonists - ChEBI - - + - - - CHEBI:22503 - CHEBI:24792 - chebi_ontology - aminoalkylindoles - CHEBI:38631 - - aminoalkylindole + + + environmental system process - - - - aminoalkylindoles - ChEBI - - + - - - - organic sodium salt - chebi_ontology - organic sodium salts - CHEBI:38700 - - organic sodium salt + + + material transport process - - - - organic sodium salt - ChEBI - - - - - organic sodium salts - ChEBI - - + - - - Any dianion containing at least one carboxy group. - carboxylic acid dianion - chebi_ontology - carboxylic acid dianions - CHEBI:38716 - - carboxylic acid dianion + + + The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. + GO:0019952 + GO:0050876 + Wikipedia:Reproduction + reproductive physiological process + biological_process + GO:0000003 + + + + + + + reproduction - - - carboxylic acid dianion - ChEBI - - - - - carboxylic acid dianions - ChEBI + + + The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. + GOC:go_curators + GOC:isa_complete + GOC:jl + ISBN:0198506732 - + - - - - - - - - - An alkaloid containing an indole skeleton. - CHEBI:24795 - CHEBI:5901 - KEGG:C06073 - Wikipedia:Indole_alkaloid - Indole alkaloid - chebi_ontology - indole alkaloids - CHEBI:38958 - - indole alkaloid + + + + + The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + glycan biosynthesis + glycan biosynthetic process + polysaccharide anabolism + polysaccharide biosynthesis + polysaccharide formation + polysaccharide synthesis + biological_process + GO:0000271 + polysaccharide biosynthetic process - - - Indole alkaloid - KEGG_COMPOUND - - - - - indole alkaloids - ChEBI + + + The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + GOC:go_curators - + - - - - A molecular entity capable of donating a hydron to an acceptor (Bronsted base). - Bronsted acid - chebi_ontology - Bronsted-Saeure - acide de Bronsted - donneur d'hydron - hydron donor - CHEBI:39141 - - Bronsted acid + + + + + The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + GO:0044244 + polysaccharide breakdown + polysaccharide catabolism + polysaccharide degradation + multicellular organismal polysaccharide catabolic process + biological_process + GO:0000272 + polysaccharide catabolic process - - - Bronsted acid - IUPAC - - - - - - Bronsted-Saeure - ChEBI - - - - - acide de Bronsted - IUPAC - - - - - donneur d'hydron - IUPAC - - - - - hydron donor - IUPAC + + + The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + PMID:33139480 - + - - - - A molecular entity capable of accepting a hydron from a donor (Bronsted acid). - Bronsted base - chebi_ontology - Bronsted-Base - accepteur d'hydron - base de Bronsted - hydron acceptor - CHEBI:39142 - - Bronsted base + + + The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). + skeletal development + biological_process + GO:0001501 + skeletal system development - - - Bronsted base - IUPAC - - - - - - Bronsted-Base - ChEBI - - - - - accepteur d'hydron - IUPAC - - - - - base de Bronsted - IUPAC - - - - - hydron acceptor - IUPAC + + + The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). + GOC:dph + GOC:jid + GOC:tb - + - - - - A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct. - Lewis base - chebi_ontology - Lewis-Base - base de Lewis - donneur d'une paire d'electrons - electron donor - CHEBI:39144 - - Lewis base + + + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + Wikipedia:Ossification + bone biosynthesis + bone formation + osteogenesis + biological_process + GO:0001503 + Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. + ossification - - - Lewis base - IUPAC - - - - - - Lewis-Base - ChEBI - - - - - base de Lewis - IUPAC - - - - - donneur d'une paire d'electrons - ChEBI - - - - - electron donor - ChEBI + + + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + GOC:mtg_mpo + PMID:17572649 - + - - - - - - - - - + + - - + + - A monovalent inorganic anion that consists of phosphoric acid in which one of the three OH groups has been deprotonated. - -1 - H2O4P - InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-1 - NBIIXXVUZAFLBC-UHFFFAOYSA-M - 96.98724 - 96.96962 - [H]OP([O-])(=O)O[H] - CHEBI:29137 - CHEBI:39739 - DrugBank:DB02831 - Gmelin:1999 - PDBeChem:2HP - dihydrogen(tetraoxidophosphate)(1-) - dihydrogenphosphate - dihydrogentetraoxophosphate(1-) - dihydrogentetraoxophosphate(V) - dihydroxidodioxidophosphate(1-) - chebi_ontology - DIHYDROGENPHOSPHATE ION - H2PO4(-) - [PO2(OH)2](-) - CHEBI:39745 - - dihydrogenphosphate + Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. + Wikipedia:Angiogenesis + blood vessel formation from pre-existing blood vessels + biological_process + GO:0001525 + angiogenesis - - - Gmelin:1999 - Gmelin - - - - - dihydrogen(tetraoxidophosphate)(1-) - IUPAC - - - - - - dihydrogenphosphate - IUPAC - - - - - - dihydrogentetraoxophosphate(1-) - IUPAC - - - - - - dihydrogentetraoxophosphate(V) - IUPAC - + + + Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. + ISBN:0878932453 - + - dihydroxidodioxidophosphate(1-) - IUPAC - - - - - - DIHYDROGENPHOSPHATE ION - PDBeChem - - - - - H2PO4(-) - IUPAC - - - - - [PO2(OH)2](-) - IUPAC + blood vessel formation from pre-existing blood vessels + - + - - + + - - + + - -2 - CO3 - InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2 - BVKZGUZCCUSVTD-UHFFFAOYSA-L - 60.00890 - 59.98584 - [O-]C([O-])=O - CHEBI:29201 - CHEBI:41605 - Beilstein:3600898 - CAS:3812-32-6 - Gmelin:1559 - PDBeChem:CO3 - carbonate - trioxidocarbonate(2-) - chebi_ontology - CARBONATE ION - CO3(2-) - Karbonat - [CO3](2-) - CHEBI:41609 - - carbonate + The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. + biological_process + GO:0001568 + blood vessel development - - - Beilstein:3600898 - Beilstein - - - - - CAS:3812-32-6 - ChemIDplus - - - - - Gmelin:1559 - Gmelin - - - - - carbonate - IUPAC - - - - - trioxidocarbonate(2-) - IUPAC - - - - - - CARBONATE ION - PDBeChem - - - - - CO3(2-) - ChEBI + + + The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. + GOC:hjd + UBERON:0001981 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. + patterning of blood vessels + biological_process + GO:0001569 + branching involved in blood vessel morphogenesis + - - - Karbonat - ChEBI + + + The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. + GOC:dph - - - [CO3](2-) - IUPAC + + + patterning of blood vessels + GOC:dph - + - - - 0 - HO - 17.00734 - 17.00274 - *O[H] - CHEBI:24706 - CHEBI:43171 - PDBeChem:OH - HYDROXY GROUP - hydroxy - hydroxy group - chebi_ontology - -OH - hydroxyl - hydroxyl group - CHEBI:43176 - - hydroxy group + + + A homeostatic process in which an organism modulates its internal body temperature. + Wikipedia:Thermoregulation + thermoregulation + biological_process + GO:0001659 + temperature homeostasis - - - HYDROXY GROUP - PDBeChem - - - - - hydroxy - IUPAC - + + + A homeostatic process in which an organism modulates its internal body temperature. + GOC:jl - + - hydroxy group - UniProt - - - - - -OH - IUPAC + thermoregulation + GOC:dph + GOC:tb + + + + + + + + Cell migration that is accomplished by extension and retraction of a pseudopodium. + ameboid cell migration + amoeboid cell migration + amoeboidal cell migration + biological_process + GO:0001667 + Note that this term refers to a mode of migration rather than to any particular cell type. + ameboidal-type cell migration + - - - hydroxyl - ChEBI + + + Cell migration that is accomplished by extension and retraction of a pseudopodium. + GOC:dph + + + + + + + + + The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + hydrochloric acid secretion + biological_process + GO:0001696 + gastric acid secretion + - - - hydroxyl group - ChEBI + + + The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + GOC:hjd - + - - - - - - - - - + + - - + + + The formation of the ectoderm, mesoderm and endoderm during gastrulation. + biological_process + GO:0001704 + formation of primary germ layer + + + + + The formation of the ectoderm, mesoderm and endoderm during gastrulation. + GOC:go_curators + + + + + + + + - - + + + The formation of ectoderm during gastrulation. + biological_process + GO:0001705 + ectoderm formation + + + + + The formation of ectoderm during gastrulation. + GOC:go_curators + + + + + + + + - - + + - A phosphate ion that is the conjugate base of dihydrogenphosphate. - -2 - HO4P - InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 - NBIIXXVUZAFLBC-UHFFFAOYSA-L - 95.97930 - 95.96234 - OP([O-])([O-])=O - CHEBI:29139 - CHEBI:43470 - Gmelin:1998 - MolBase:1628 - PDBeChem:PI - PDBeChem:PO4 - hydrogen(tetraoxidophosphate)(2-) - hydrogenphosphate - hydrogentetraoxophosphate(2-) - hydrogentetraoxophosphate(V) - hydroxidotrioxidophosphate(2-) - chebi_ontology - HPO4(2-) - HYDROGENPHOSPHATE ION - INORGANIC PHOSPHATE GROUP - [P(OH)O3](2-) - [PO3(OH)](2-) - hydrogen phosphate - phosphate - CHEBI:43474 - - hydrogenphosphate + The formation of the endoderm during gastrulation. + endoblast formation + biological_process + GO:0001706 + endoderm formation - - - Gmelin:1998 - Gmelin - - - - - hydrogen(tetraoxidophosphate)(2-) - IUPAC - + + + The formation of the endoderm during gastrulation. + GOC:go_curators - - - hydrogenphosphate - IUPAC - + + + endoblast formation + GOC:dph + GOC:sdb_2009 + GOC:tb + + + + + + + + + + + + + + The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. + biological_process + GO:0001707 + mesoderm formation + - - - hydrogentetraoxophosphate(2-) - IUPAC - + + + The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. + GOC:go_curators + + + + + + + + + The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. + branching morphogenesis + biological_process + GO:0001763 + morphogenesis of a branching structure + - - - hydrogentetraoxophosphate(V) - IUPAC - + + + The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. + ISBN:0721662544 - + - hydroxidotrioxidophosphate(2-) - IUPAC - - - - - - HPO4(2-) - IUPAC - - - - - HYDROGENPHOSPHATE ION - PDBeChem - - - - - INORGANIC PHOSPHATE GROUP - PDBeChem - - - - - [P(OH)O3](2-) - MolBase - - - - - [PO3(OH)](2-) - IUPAC + branching morphogenesis + GOC:dph + + + + + + + + + The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. + 5-HT secretion + 5-hydroxytryptamine secretion + biological_process + serotonin release + GO:0001820 + serotonin secretion + - - - hydrogen phosphate - ChEBI + + + The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. + GOC:ef + ISBN:0198506732 + ISBN:0781735149 - + - phosphate - UniProt + serotonin release + GOC:tb - + - - + + - - + + + The morphogenesis of an embryonic epithelium into a tube-shaped structure. + biological_process + GO:0001838 + embryonic epithelial tube formation + + + + + The morphogenesis of an embryonic epithelium into a tube-shaped structure. + GOC:dph + ISBN:0824072820 + + + + + + + + - - + + - -1 - HO4S - InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 - QAOWNCQODCNURD-UHFFFAOYSA-M - 97.07154 - 96.96010 - [H]OS([O-])(=O)=O - CHEBI:29199 - CHEBI:45693 - Gmelin:2121 - hydrogen(tetraoxidosulfate)(1-) - hydrogensulfate - hydrogensulfate(1-) - hydrogentetraoxosulfate(1-) - hydrogentetraoxosulfate(VI) - hydroxidotrioxidosulfate(1-) - chebi_ontology - HSO4(-) - HYDROGEN SULFATE - [SO3(OH)](-) - CHEBI:45696 - - hydrogensulfate + The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. + GO:0001679 + Wikipedia:Neurulation + neural tube morphogenesis + neurulation + biological_process + GO:0001841 + neural tube formation - - - Gmelin:2121 - Gmelin + + + The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. + GOC:dph + ISBN:0878932437 - + - hydrogen(tetraoxidosulfate)(1-) - IUPAC - - - - - - hydrogensulfate - IUPAC - - - - - hydrogensulfate(1-) - IUPAC - - - - - - hydrogentetraoxosulfate(1-) - IUPAC - - - - - - hydrogentetraoxosulfate(VI) - IUPAC - - - - - - hydroxidotrioxidosulfate(1-) - IUPAC - - - - - - HSO4(-) - IUPAC - - - - - HYDROGEN SULFATE - PDBeChem + neural tube morphogenesis + GOC:dph + + + + + + + + + + + + + + The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. + biological_process + vascular system development + GO:0001944 + vasculature development + - - - [SO3(OH)](-) - IUPAC + + + The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. + GOC:dph + UBERON:0002409 - + - - - 0 - O - 15.99940 - 15.99491 - O=* - CHEBI:29353 - CHEBI:44607 - PDBeChem:O - OXO GROUP - oxo - chebi_ontology - =O - CHEBI:46629 - - oxo group + + + Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells. + Wikipedia:Intramembranous_ossification + dermal ossification + biological_process + intramembranous bone ossification + GO:0001957 + An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. + intramembranous ossification - - - OXO GROUP - PDBeChem + + + Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells. + ISBN:0878932437 - - - oxo - IUPAC - + + + dermal ossification + GO_REF:0000034 - + - =O - IUPAC + intramembranous bone ossification + GOC:cjm - + - - - - A liquid that can dissolve other substances (solutes) without any change in their chemical composition. - Wikipedia:Solvent - chebi_ontology - Loesungsmittel - solvant - solvents - CHEBI:46787 - - solvent + + + + + + + + + The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. + epithelium morphogenesis + biological_process + GO:0002009 + morphogenesis of an epithelium - - - Loesungsmittel - ChEBI - - - - - solvant - ChEBI - - - - - solvents - ChEBI + + + The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. + GOC:dph + GOC:jl + GOC:tb + ISBN:0198506732 - + - - - 0 - CHO2 - 45.01744 - 44.99765 - *C(=O)O - CHEBI:23025 - CHEBI:41420 - PDBeChem:FMT - CARBOXY GROUP - carboxy - chebi_ontology - -C(O)OH - -CO2H - -COOH - carboxyl group - CHEBI:46883 - - carboxy group + + + + Any process that modulates the frequency or rate of heart contraction. + cardiac chronotropy + regulation of heart contraction rate + regulation of rate of heart contraction + biological_process + GO:0002027 + regulation of heart rate - - - CARBOXY GROUP - PDBeChem + + + Any process that modulates the frequency or rate of heart contraction. + GOC:dph + GOC:tb + PMID:10358008 - + - carboxy - IUPAC - - - - - - -C(O)OH - IUPAC - - - - - -CO2H - ChEBI - - - - - -COOH - IUPAC - - - - - carboxyl group - ChEBI + cardiac chronotropy + GOC:dph + GOC:tb - + - - + + + + + + + + + + + + + + - - + + - Any carboxylic ester where the carboxylic acid component is acetic acid. - 0 - C2H3O2R - 59.04400 - 59.01330 - CC(=O)O[*] - CHEBI:13244 - CHEBI:13799 - CHEBI:22189 - CHEBI:2406 - KEGG:C01883 - Wikipedia:Acetate#Esters - chebi_ontology - Acetic ester - Acetyl ester - acetate - acetate esters - acetates - acetyl esters - an acetyl ester - CHEBI:47622 - - acetate ester + The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. + up regulation of mesenchymal cell proliferation + up-regulation of mesenchymal cell proliferation + upregulation of mesenchymal cell proliferation + activation of mesenchymal cell proliferation + stimulation of mesenchymal cell proliferation + biological_process + GO:0002053 + positive regulation of mesenchymal cell proliferation - - - Acetic ester - KEGG_COMPOUND - - - - - Acetyl ester - KEGG_COMPOUND - - - - - acetate - ChEBI - - - - - acetate esters - ChEBI - - - - - acetates - ChEBI - - - - - acetyl esters - ChEBI - - - - - an acetyl ester - UniProt + + + The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. + GOC:dph - + - - - + + + + + + + + + + + + + + - - + + - Any steroid substituted by at least one carboxy group. - chebi_ontology - steroid acids - CHEBI:47891 - - steroid acid + A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. + neurological control of breathing + regulation of respiratory gaseous exchange by neurological system process + biological_process + GO:0002087 + regulation of respiratory gaseous exchange by nervous system process - - - steroid acids - ChEBI + + + A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. + GOC:dph + GOC:tb + PMID:12458206 + + + + + neurological control of breathing + GOC:dph + GOC:tb - + - - - - chebi_ontology - Schwefeloxide - oxides of sulfur - sulfur oxides - CHEBI:48154 - - sulfur oxide + + + The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. + biological_process + GO:0002119 + nematode larval development - - - Schwefeloxide - ChEBI - - - - - oxides of sulfur - ChEBI - - - - - sulfur oxides - ChEBI + + + The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. + GOC:ems + GOC:kmv - + - - - A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds. - polar solvent - chebi_ontology - polar solvents - CHEBI:48354 - - polar solvent + + + + The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters. + biological_process + GO:0002164 + larval development - - - polar solvent - IUPAC - - - - - - polar solvents - ChEBI + + + The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters. + GOC:jid + ISBN:0877795088 - + - - - - A polar solvent that is capable of acting as a hydron (proton) donor. - protogenic solvent - chebi_ontology - CHEBI:48356 - - protic solvent + + + An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. + immune response in organ or tissue + biological_process + GO:0002251 + organ or tissue specific immune response - - - protogenic solvent - IUPAC - + + + An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. + GOC:jal + GO_REF:0000022 - + - - - Any drug that acts on an alpha-adrenergic receptor. - chebi_ontology - alpha-adrenergic drugs - CHEBI:48539 - - alpha-adrenergic drug + + + + + + + + + + + + + + + + + + + Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. + + Wikipedia:Immune_system + biological_process + GO:0002376 + + + + + + + Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). + immune system process - - - alpha-adrenergic drugs - ChEBI + + + Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. + GOC:add + GO_REF:0000022 - + - - - Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own. - agonist - chebi_ontology - agonista - agoniste - agonists - CHEBI:48705 - - agonist + + + An immune response taking place in the liver. + biological_process + GO:0002384 + hepatic immune response - - - agonist - IUPAC - - - - - - agonista - ChEBI - - - - - agoniste - ChEBI + + + An immune response taking place in the liver. + GOC:jal + GO_REF:0000022 + ISBN:0781735149 + + + + + + + + + The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. + biological_process + GO:0002520 + + immune system development + - - - agonists - ChEBI + + + The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. + GOC:add + GOC:dph - + - - - - - + + + + + + + + + + + + + - - + + - 0 - H - InChI=1S/H - YZCKVEUIGOORGS-UHFFFAOYSA-N - 1.00794 - 1.00783 - [H] - CHEBI:24634 - CHEBI:49636 - WebElements:H - hydrogen - chebi_ontology - 1H - H - Wasserstoff - hidrogeno - hydrogen - hydrogene - CHEBI:49637 - - hydrogen atom + Any process that modulates the frequency, rate, or extent of an immune system process. + biological_process + GO:0002682 + regulation of immune system process - - - hydrogen - IUPAC - - - - - - 1H - IUPAC - - - - - H - IUPAC - - - - - Wasserstoff - ChEBI - - - - - hidrogeno - ChEBI - - - - - hydrogen - ChEBI - - - - - hydrogene - ChEBI + + + Any process that modulates the frequency, rate, or extent of an immune system process. + GOC:add - + - - - - - - - - - + + + + + + + + + + + + + + - - + + - A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups. - chebi_ontology - organic amino compounds - CHEBI:50047 - - organic amino compound + Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. + down regulation of immune system process + down-regulation of immune system process + downregulation of immune system process + inhibition of immune system process + biological_process + GO:0002683 + negative regulation of immune system process - - - organic amino compounds - ChEBI + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. + GOC:add - + - - + + + + + + + + + + + + + + - - + + - Any anion formed by loss of a proton from a steroid acid. - chebi_ontology - steroid acid anions - CHEBI:50160 - - steroid acid anion + Any process that activates or increases the frequency, rate, or extent of an immune system process. + up regulation of immune system process + up-regulation of immune system process + upregulation of immune system process + activation of immune system process + stimulation of immune system process + biological_process + GO:0002684 + positive regulation of immune system process - - - steroid acid anions - ChEBI + + + Any process that activates or increases the frequency, rate, or extent of an immune system process. + GOC:add - + - - - chebi_ontology - canonical nucleotide residues - CHEBI:50297 - - canonical nucleotide residue + + + + The controlled release of a peptide from a cell or a tissue. + biological_process + GO:0002790 + peptide secretion - - - canonical nucleotide residues - ChEBI + + + The controlled release of a peptide from a cell or a tissue. + GOC:add - + - - - chebi_ontology - canonical deoxyribonucleotide residues - CHEBI:50298 - - canonical deoxyribonucleotide residue + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate, or extent of peptide secretion. + biological_process + GO:0002791 + regulation of peptide secretion - - - canonical deoxyribonucleotide residues - ChEBI + + + Any process that modulates the frequency, rate, or extent of peptide secretion. + GOC:add - + - - - chebi_ontology - canonical ribonucleotide residues - CHEBI:50299 - - canonical ribonucleotide residue + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. + down regulation of peptide secretion + down-regulation of peptide secretion + downregulation of peptide secretion + inhibition of peptide secretion + biological_process + GO:0002792 + negative regulation of peptide secretion - - - canonical ribonucleotide residues - ChEBI + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. + GOC:add - + - - - chebi_ontology - CHEBI:50312 - - onium compound + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate, or extent of peptide secretion. + up regulation of peptide secretion + up-regulation of peptide secretion + upregulation of peptide secretion + activation of peptide secretion + stimulation of peptide secretion + biological_process + GO:0002793 + positive regulation of peptide secretion + + + + Any process that activates or increases the frequency, rate, or extent of peptide secretion. + GOC:add + - + - - - Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families. - onium cations - chebi_ontology - onium cations - onium ion - onium ions - CHEBI:50313 - - onium cation + + + + + + + + + + + + + + + + + + + + + A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. + puberty + biological_process + reproductive developmental process + GO:0003006 + developmental process involved in reproduction - - - onium cations - IUPAC - - - - - - onium cations - ChEBI + + + A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. + GOC:dph + GOC:isa_complete - - - onium ion - ChEBI + + + puberty + GOC:dph - + - onium ions - ChEBI + reproductive developmental process + GOC:dph + GOC:tb - + - - - chebi_ontology - nucleotide residues - CHEBI:50319 - - nucleotide residue + + + A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. + organ system process + biological_process + GO:0003008 + system process - - - nucleotide residues - ChEBI + + + A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. + GOC:mtg_cardio - + - - - chebi_ontology - nucleoside residues - CHEBI:50320 - - nucleoside residue + + + A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. + biological_process + muscle physiological process + GO:0003012 + + + muscle system process - - - nucleoside residues - ChEBI + + + A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. + GOC:mtg_cardio - + - - - Drug used to cause constriction of the blood vessels. - chebi_ontology - CHEBI:50514 - - vasoconstrictor agent + + + A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. + Wikipedia:Circulatory_system + biological_process + GO:0003013 + + + circulatory system process + + + + A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. + GOC:mtg_cardio + - + - - - - - - - - - Any molecular entity that contains carbon. - CHEBI:25700 - CHEBI:33244 - chebi_ontology - organic compounds - organic entity - organic molecular entities - CHEBI:50860 - - organic molecular entity + + + A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). + excretory system process + biological_process + kidney system process + GO:0003014 + + renal system process - - - organic compounds - ChEBI - - - - - organic entity - ChEBI - - - - - organic molecular entities - ChEBI + + + A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). + GOC:cjm + GOC:mtg_cardio + GOC:mtg_kidney_jan10 - + - - - A role is particular behaviour which a material entity may exhibit. - chebi_ontology - CHEBI:50906 - - role + + + A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. + biological_process + cardiac process + GO:0003015 + heart process + + + + A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. + GOC:mtg_cardio + - + - - - - A poison that interferes with the functions of the nervous system. - CHEBI:50911 - Wikipedia:Neurotoxin - chebi_ontology - agente neurotoxico - nerve poison - nerve poisons - neurotoxic agent - neurotoxic agents - neurotoxicant - neurotoxins - CHEBI:50910 - - neurotoxin + + + + + + + + + A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. + GO:0010802 + respiratory gaseous exchange + biological_process + GO:0003016 + + respiratory system process - - - agente neurotoxico - ChEBI - - - - - nerve poison - ChEBI - - - - - nerve poisons - ChEBI - - - - - neurotoxic agent - ChEBI - - - - - neurotoxic agents - ChEBI - - - - - neurotoxicant - ChEBI - - - - - neurotoxins - ChEBI + + + A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. + GOC:dph + GOC:mtg_cardio + GOC:tb - + - - - - - - - - - A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group. - chebi_ontology - primary amino compounds - CHEBI:50994 - - primary amino compound + + + A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process. + molecular process + GO:0005554 + molecular function + molecular_function + GO:0003674 + + + + + + + Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. + molecular_function - - - primary amino compounds - ChEBI + + + A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process. + GOC:pdt - + - - - A role played by the molecular entity or part thereof within a chemical context. - chebi_ontology - CHEBI:51086 - - chemical role + + + catalytic activity - + - - - - - - - - - CHEBI:25556 - CHEBI:7594 - KEGG:C06061 - chebi_ontology - Nitrogenous compounds - nitrogen compounds - nitrogen molecular entities - CHEBI:51143 - - nitrogen molecular entity + + + A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome). + The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. + GO:0008372 + NIF_Subcellular:sao1337158144 + cell or subcellular entity + cellular component + cellular_component + subcellular entity + GO:0005575 + + + + + + + Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. + Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. + cellular_component - - - Nitrogenous compounds - KEGG_COMPOUND + + + A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome). + GOC:pdt + NIF_Subcellular:sao1337158144 - - - nitrogen compounds - ChEBI + + + The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. + GOC:go_curators - + - nitrogen molecular entities - ChEBI + subcellular entity + NIF_Subcellular:nlx_subcell_100315 - + - - - An organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case. - chebi_ontology - dipolar compounds - CHEBI:51151 - - dipolar compound + + + The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. + Wikipedia:Extracellular + extracellular + cellular_component + GO:0005576 + + + + + + + + + + + + Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. + extracellular region - - - dipolar compounds - ChEBI + + + The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. + GOC:go_curators - + - - - Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s). - chebi_ontology - organodiyl groups - CHEBI:51422 - - organodiyl group + + + + + + + + + A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. + fibrinogen + fibrinogen alpha chain + fibrinogen beta chain + fibrinogen gamma chain + cellular_component + GO:0005577 + fibrinogen complex - - - organodiyl groups - ChEBI + + + A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. + ISBN:0198547684 - - - - - chebi_ontology - CHEBI:51446 - - organic divalent group - - - + - - - - - chebi_ontology - CHEBI:51447 - - organic univalent group - - - - - - - - - - chebi_ontology - organic polycyclic compounds - CHEBI:51958 - - organic polycyclic compound + + + A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. + Wikipedia:Collagen + cellular_component + GO:0005581 + collagen trimer - - - organic polycyclic compounds - ChEBI + + + A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. + GOC:dos + GOC:mah + ISBN:0721639976 + PMID:19693541 + PMID:21421911 - - - - - A biological role played by the molecular entity or part thereof within a biochemical context. - chebi_ontology - CHEBI:52206 - - biochemical role - - - - - + - - - A role played by the molecular entity or part thereof which causes the development of a pathological process. - chebi_ontology - etiopathogenetic agent - etiopathogenetic role - CHEBI:52209 - - aetiopathogenetic role + + + + + + + + + + + + + + + + + + + + Any triple helical collagen trimer that forms fibrils. + cellular_component + GO:0005583 + fibrillar collagen trimer - - - etiopathogenetic agent - ChEBI - - - - - etiopathogenetic role - ChEBI + + + Any triple helical collagen trimer that forms fibrils. + GOC:mah + ISBN:0721639976 + PMID:21421911 - + - - - A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties. - chebi_ontology - CHEBI:52210 - - pharmacological role + + + A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils. + Wikipedia:Collagen_type_II + cellular_component + GO:0005585 + collagen type II trimer + + + + A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils. + ISBN:0721639976 + - + - - - chebi_ontology - CHEBI:52211 - - physiological role + + + + A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes. + Wikipedia:Collagen_type_IV + cellular_component + GO:0005587 + collagen type IV trimer + + + + A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes. + ISBN:0721639976 + PMID:19693541 + PMID:21421911 + - + - - - Any substance introduced into a living organism with therapeutic or diagnostic purpose. - CHEBI:33293 - CHEBI:33294 - chebi_ontology - farmaco - medicament - pharmaceuticals - CHEBI:52217 - - pharmaceutical + + + A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. + GO:0005605 + GO:0008003 + Wikipedia:Basement_membrane + cellular_component + basal lamina + basement lamina + lamina densa + GO:0005604 + Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer. + basement membrane - - - farmaco - ChEBI - - - - - medicament - ChEBI - - - - - pharmaceuticals - ChEBI + + + A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. + ISBN:0198547684 + PMID:22505934 - + - - - An organic group that consists of a closed ring. It may be a substituent or a skeleton. - chebi_ontology - cyclic organic groups - CHEBI:52845 - - cyclic organic group + + + + + + + + + That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. + NIF_Subcellular:sao1425028079 + cellular_component + intercellular space + GO:0005615 + + + + + Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. + extracellular space - - - cyclic organic groups - ChEBI + + + That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. + ISBN:0198547684 - + - - - The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds. - chebi_ontology - antigenic determinant - epitope function - epitope role - CHEBI:53000 - - epitope + + + + + + + + + A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. + https://github.com/geneontology/go-ontology/issues/17776 + Wikipedia:Intracellular + internal to cell + intracellular + protoplasm + cellular_component + nucleocytoplasm + protoplast + GO:0005622 + + + + + intracellular anatomical structure - - - antigenic determinant - ChEBI + + + A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. + ISBN:0198506732 - + - epitope function - ChEBI + nucleocytoplasm + GOC:mah - + - epitope role - ChEBI + protoplast + GOC:mah - + - - - A polymer carrying multiple negative charges. - chebi_ontology - polyanion - polyanions - CHEBI:53309 - - polyanionic macromolecule + + + + + + + + + The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. + https://github.com/geneontology/go-ontology/issues/23023 + Wikipedia:Cytoplasm + cellular_component + GO:0005737 + + + + + + + + cytoplasm - - - polyanion - ChEBI - - - - - polyanions - SUBMITTER + + + The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. + ISBN:0198547684 - + - - - A macromolecule containing ionic groups. - chebi_ontology - ionic polymer - polyionic macromolecule - CHEBI:53368 - - ionic macromolecule + + + A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. + Wikipedia:Cytoskeleton + cellular_component + GO:0005856 + + + + + + + + + + + + cytoskeleton - - - ionic polymer - ChEBI - - - - - polyionic macromolecule - ChEBI + + + A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. + GOC:mah + PMID:16959967 + PMID:27419875 - + - - - A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence. - 0 - C153H225N43O49S - InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1 - MASNOZXLGMXCHN-ZLPAWPGGSA-N - 3482.74700 - 3480.61570 - CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O - CAS:16941-32-5 - CAS:9007-92-5 - DrugBank:DB00040 - Drug_Central:2994 - KEGG:C01501 - KEGG:D00116 - PMID:21940356 - PMID:22014161 - PMID:22154917 - PMID:22166985 - PMID:22167521 - PMID:22214853 - PMID:22227186 - PMID:22286080 - PMID:22294753 - PMID:22318544 - PMID:22334714 - PMID:22399501 - PMID:22438981 - PMID:22454291 - Reaxys:13191924 - Wikipedia:Glucagon - Glucagon - L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine - chebi_ontology - Glucagone - HSQGTFTSDYSKYLDSRRAQDFVQWLMNT - His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr - His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr - glucagon - glucagonum - CHEBI:5391 - - glucagon + + + + + + + + + A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. + FMA:63850 + NIF_Subcellular:sao1588493326 + Wikipedia:Actin + microfilament + cellular_component + GO:0005884 + actin filament - - - CAS:16941-32-5 - ChemIDplus - - - - - CAS:9007-92-5 - ChemIDplus - - - - - CAS:9007-92-5 - KEGG COMPOUND - - - - - Drug_Central:2994 - DrugCentral - - - - - PMID:21940356 - Europe PMC - - - - - PMID:22014161 - Europe PMC - - - - - PMID:22154917 - Europe PMC - - - - - PMID:22166985 - Europe PMC - - - - - PMID:22167521 - Europe PMC - - - - - PMID:22214853 - Europe PMC - - - - - PMID:22227186 - Europe PMC - - - - - PMID:22286080 - Europe PMC - - - - - PMID:22294753 - Europe PMC - - - - - PMID:22318544 - Europe PMC - - - - - PMID:22334714 - Europe PMC - - - - - PMID:22399501 - Europe PMC - - - - - PMID:22438981 - Europe PMC - - - - - PMID:22454291 - Europe PMC - - - - - Reaxys:13191924 - Reaxys - - - - - Glucagon - KEGG_COMPOUND - - - - - L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine - IUPAC - - - - - - Glucagone - ChemIDplus - - - - - HSQGTFTSDYSKYLDSRRAQDFVQWLMNT - ChEBI - - - - - His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr - ChEBI - - - - - His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr - ChemIDplus - - - - - glucagon - ChemIDplus - - - - - - glucagonum - ChemIDplus - + + + A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. + GOC:mah + ISBN:0198506732 + PMID:10666339 - + - - - A cyclic compound having as ring members atoms of at least two different elements. - Heterocyclic compound - chebi_ontology - compuesto heterociclico - compuestos heterociclicos - heterocycle - heterocyclic compounds - CHEBI:5686 - - heterocyclic compound + + + + + + + + + The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. + GO:0005904 + juxtamembrane + NIF_Subcellular:sao1663586795 + Wikipedia:Cell_membrane + cell membrane + cellular membrane + cytoplasmic membrane + plasmalemma + bacterial inner membrane + inner endospore membrane + plasma membrane lipid bilayer + cellular_component + GO:0005886 + + + + + + + + + + + plasma membrane - - - Heterocyclic compound - KEGG_COMPOUND - - - - - compuesto heterociclico - IUPAC - - - - - compuestos heterociclicos - IUPAC + + + The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. + ISBN:0716731363 - - - heterocycle - ChEBI + + + cellular membrane + NIF_Subcellular:sao6433132645 - - - heterocyclic compounds - ChEBI + + + plasma membrane lipid bilayer + GOC:mah - + - - - - - - - - - + + - - + + - - + + + + + + - + - - + + - - An ammonium ion that is the conjugate acid of tryptamine arising from protonation of the primary amino group; major species at pH 7.3. - +1 - C10H13N2 - InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2/p+1 - APJYDQYYACXCRM-UHFFFAOYSA-O - 161.22310 - 161.10732 - [NH3+]CCc1c[nH]c2ccccc12 - Gmelin:533978 - 2-(1H-indol-3-yl)ethanaminium - chebi_ontology - tryptamine - tryptaminium cation - tryptaminium(1+) - CHEBI:57887 - - tryptaminium + + Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. + + NIF_Subcellular:sao671419673 + Wikipedia:Microvillus + cellular_component + microvilli + GO:0005902 + + Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. + microvillus - - - Gmelin:533978 - Gmelin - - - - - 2-(1H-indol-3-yl)ethanaminium - IUPAC - - - - - - tryptamine - UniProt - - - - - tryptaminium cation - ChEBI + + + Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. + ISBN:0815316194 - + - tryptaminium(1+) - ChEBI + microvilli + NIF_Subcellular:sao671419673 - + - - - - - - - - - - - - - - - - - A dicarboxylic acid dianion obtained by deprotonation of the two carboxy groups of bilirubin; major species at pH 7.3. - -2 - C33H34N4O6 - InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- - BPYKTIZUTYGOLE-IFADSCNNSA-L - 582.64630 - 582.24893 - CC1=C(C=C)\C(NC1=O)=C\c1[nH]c(Cc2[nH]c(\C=C3NC(=O)C(C=C)=C/3C)c(C)c2CCC([O-])=O)c(CCC([O-])=O)c1C - Beilstein:4083310 - chebi_ontology - 2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoate - bilirubin IXalpha - bilirubin dianion - CHEBI:57977 - - bilirubin(2-) + + + A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. + https://github.com/geneontology/go-ontology/issues/22122 + cell-cell contact region + cell-cell contact zone + NIF_Subcellular:sao1922892319 + intercellular junction + cellular_component + GO:0005911 + cell-cell junction - - - Beilstein:4083310 - Beilstein - - - - - 2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoate - ChEBI - - - - - bilirubin IXalpha - UniProt + + + A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. + GOC:aruk + GOC:bc + GOC:dgh + GOC:hb + GOC:mah + PMID:21422226 + PMID:28096264 - - - bilirubin dianion - ChEBI + + + intercellular junction + NIF_Subcellular:sao1395777368 - + - - - - - - - - - + + + + + + + + + + + + + - - + + - An organic anion of general formula RS(=O)2O(-) where R is an organyl group. - -1 - O4SR - 96.06300 - 95.95173 - [O-]S(=O)(=O)O[*] - chebi_ontology - organosulfate oxoanions - CHEBI:58958 - - organosulfate oxoanion + The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. + Wikipedia:Cell_cortex + cellular_component + cell periphery + peripheral cytoplasm + GO:0005938 + + + cell cortex - - - organosulfate oxoanions - ChEBI + + + The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. + GOC:mah + ISBN:0815316194 - + - - - An organic anion arising from deprotonation of a acyclic tetrapyrrole compound. - chebi_ontology - acyclic tetrapyrrole anion - acyclic tetrapyrrole anions - linear tetrapyrrole anions - CHEBI:59252 - - linear tetrapyrrole anion + + + + The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + https://github.com/geneontology/go-ontology/issues/22880 + jl + 2012-10-23T15:40:34Z + GO:0044261 + GO:0044723 + Wikipedia:Carbohydrate_metabolism + carbohydrate metabolism + biological_process + GO:0005975 + + + + + + + + + + + + carbohydrate metabolic process - - - acyclic tetrapyrrole anion - ChEBI - - - - - acyclic tetrapyrrole anions - ChEBI - - - - - linear tetrapyrrole anions - ChEBI + + + The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + GOC:mah + ISBN:0198506732 - - - - - Compounds containing one or more phosphoric acid units. - chebi_ontology - CHEBI:59698 - - phosphoric acids - - - - - + - - - - A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons. - chebi_ontology - nucleophile - nucleophiles - nucleophilic reagents - CHEBI:59740 - - nucleophilic reagent + + + + The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + GO:0044263 + polysaccharide metabolism + glycan metabolic process + glycan metabolism + multicellular organismal polysaccharide metabolic process + biological_process + GO:0005976 + + polysaccharide metabolic process - - - nucleophile - ChEBI - - - - - nucleophiles - ChEBI - - - - - nucleophilic reagents - ChEBI + + + The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + ISBN:0198547684 - + - - - A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types. - chebi_ontology - Chemische Substanz - CHEBI:59999 - - chemical substance + + + + The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. + glycogen metabolism + biological_process + GO:0005977 + glycogen metabolic process - - - Chemische Substanz - ChEBI + + + The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. + ISBN:0198506732 - + - - - A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind. - chebi_ontology - Mischung - CHEBI:60004 - - mixture + + + + The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. + MetaCyc:GLYCOGENSYNTH-PWY + glycogen anabolism + glycogen biosynthesis + glycogen formation + glycogen synthesis + biological_process + GO:0005978 + glycogen biosynthetic process - - - Mischung - ChEBI + + + The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. + ISBN:0198506732 - + - - + + + + + + + + + + + + + + - - + + - A polymer is a mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc.. - Wikipedia:Polymer - Polymer - chebi_ontology - Kunststoff - CHEBI:60027 - - polymer + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + regulation of glycogen anabolism + regulation of glycogen biosynthesis + regulation of glycogen formation + regulation of glycogen synthesis + biological_process + GO:0005979 + regulation of glycogen biosynthetic process - - - Polymer - ChEBI - - - - - Kunststoff - ChEBI + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + GOC:go_curators - + - - - - - - - - - An ionic polymer is a polymer, composed of ionic macromolecules. - chebi_ontology - polyionic polymer - CHEBI:60164 - - ionic polymer + + + + + The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. + MetaCyc:GLYCOCAT-PWY + glycogen breakdown + glycogen catabolism + glycogen degradation + glycogenolysis + biological_process + GO:0005980 + glycogen catabolic process - - - polyionic polymer - ChEBI + + + The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. + ISBN:0198506732 - - - - - - - - An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one. - chebi_ontology - a monovalent cation - CHEBI:60242 - - monovalent inorganic cation - - - - a monovalent cation - UniProt + + + glycogenolysis + GOC:sl - + - - + + + + + + + + + + + + + + - - + + - Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged. - 0 - C2H4NO2R(C2H2NOR)n - chebi_ontology - a peptide - peptide zwitterions - CHEBI:60466 - - peptide zwitterion + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + regulation of glycogen breakdown + regulation of glycogen catabolism + regulation of glycogen degradation + regulation of glycogenolysis + biological_process + GO:0005981 + regulation of glycogen catabolic process - - - a peptide - UniProt + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + GOC:go_curators - - - peptide zwitterions - ChEBI + + + regulation of glycogenolysis + GOC:sl - + - - - - - - - - - - Any compound that has a nucleobase as a part. - chebi_ontology - nucleobase-containing compound - nucleobase-containing compounds - nucleobase-containing molecular entities - CHEBI:61120 - - nucleobase-containing molecular entity + + + + The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. + monosaccharide metabolism + biological_process + GO:0005996 + monosaccharide metabolic process - - - nucleobase-containing compound - SUBMITTER - - - - - nucleobase-containing compounds - ChEBI - - - - - nucleobase-containing molecular entities - ChEBI + + + The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. + ISBN:0198506732 - + - - - - - - - - - A polymer, composed of polyanion macromolecules. - chebi_ontology - polyanion - polyanions - CHEBI:61469 - - polyanionic polymer + + + The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. + cellular glucose metabolic process + glucose metabolism + biological_process + GO:0006006 + glucose metabolic process - - - polyanion - ChEBI + + + The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. + ISBN:0198506732 - - - polyanions - ChEBI + + + cellular glucose metabolic process + GOC:vw - + - - - A substance that removes electrons from another reactant in a redox reaction. - chebi_ontology - oxidant - oxidants - oxidiser - oxidisers - oxidising agents - oxidizer - oxidizers - oxidizing agent - oxidizing agents - CHEBI:63248 - - oxidising agent + + + + The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, occurring at the level of an individual cell. + cellular glucan metabolism + biological_process + GO:0006073 + cellular glucan metabolic process - - - oxidant - ChEBI - - - - - oxidants - ChEBI - - - - - oxidiser - ChEBI - - - - - oxidisers - ChEBI - - - - - oxidising agents - ChEBI - - - - - oxidizer - ChEBI - - - - - oxidizers - ChEBI - - - - - oxidizing agent - ChEBI - - - - - oxidizing agents - ChEBI + + + The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, occurring at the level of an individual cell. + ISBN:0198547684 - + - - - - - - - - - Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds. - chebi_ontology - carbohydrate derivatives - derivatised carbohydrate - derivatised carbohydrates - derivatized carbohydrate - derivatized carbohydrates - CHEBI:63299 - - carbohydrate derivative + + + + + The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. + organic acid metabolism + biological_process + GO:0006082 + + organic acid metabolic process - - - carbohydrate derivatives - ChEBI - - - - - derivatised carbohydrate - ChEBI - - - - - derivatised carbohydrates - ChEBI + + + The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. + ISBN:0198506732 + + + + + + + + The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. + energy pathways + biological_process + intermediary metabolism + metabolic energy generation + GO:0006091 + + + + + + + + + + + generation of precursor metabolites and energy + - - - derivatized carbohydrate - ChEBI + + + The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. + GOC:jl - + - derivatized carbohydrates - ChEBI + intermediary metabolism + GOC:mah - + - - - - - - - - + + + + + + + + + + + + + - - + + - A carbohydrate derivative that is formally obtained from a carbohydrate acid. - chebi_ontology - carbohydrate acid derivatives - CHEBI:63436 - - carbohydrate acid derivative + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. + regulation of carbohydrate metabolism + biological_process + GO:0006109 + regulation of carbohydrate metabolic process - - - carbohydrate acid derivatives - ChEBI + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. + GOC:go_curators - + - - - An aralylamino compound which contains one amino group connected to an aromatic ring by a two-carbon chain. Monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes. - PMID:21822758 - PMID:21993877 - PMID:22005599 - PMID:22082101 - PMID:22153577 - PMID:22213370 - PMID:22218931 - PMID:22342987 - PMID:22371656 - chebi_ontology - monoamines - naturally occurring monoamine - naturally occurring monoamines - CHEBI:63534 - - monoamine - - - - - PMID:21822758 - Europe PMC - - - - - PMID:21993877 - Europe PMC - - - - - PMID:22005599 - Europe PMC - - - - - PMID:22082101 - Europe PMC - - - - - PMID:22153577 - Europe PMC - - - - - PMID:22213370 - Europe PMC - - - - - PMID:22218931 - Europe PMC - - - - - PMID:22342987 - Europe PMC - - - - - PMID:22371656 - Europe PMC - - - - - monoamines - ChEBI - - - - - naturally occurring monoamine - ChEBI - + + + The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. + energy reserve metabolism + biological_process + GO:0006112 + + energy reserve metabolic process + - - - naturally occurring monoamines - ChEBI + + + The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. + GOC:mah - + - - - - - - - - - - - - - - - A carboxylic acid anion resulting from the deprotonation of the carboxy group of a carbohydrate acid derivative. - chebi_ontology - carbohydrate acid anion derivative - carbohydrate acid anion derivatives - carbohydrate acid derivative anions - CHEBI:63551 - - carbohydrate acid derivative anion + + + The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. + protein anabolism + biological_process + GO:0006412 + translation - - - carbohydrate acid anion derivative - ChEBI - - - - - carbohydrate acid anion derivatives - ChEBI - - - - - carbohydrate acid derivative anions - ChEBI + + + The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. + GOC:go_curators - + - - - - Any substance which is added to food to preserve or enhance its flavour and/or appearance. - Wikipedia:Food_additive - chebi_ontology - food additives - CHEBI:64047 - - food additive + + + + The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. + Wikipedia:Lipid_metabolism + lipid metabolism + biological_process + GO:0006629 + + + + + + + + + + + + + lipid metabolic process - - - food additives - ChEBI + + + The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. + GOC:ma - + - - - A food additive that is used to change or otherwise control the acidity or alkalinity of foods. They may be acids, bases, neutralising agents or buffering agents. - Wikipedia:Acidity_regulator - chebi_ontology - acidity regulator - acidity regulators - food acidity regulators - pH control agent - pH control agents - CHEBI:64049 - - food acidity regulator + + + + + The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. + Wikipedia:Steroid_metabolisms#Steroid_biosynthesis + steroid anabolism + steroid biosynthesis + steroid formation + steroid synthesis + steroidogenesis + biological_process + GO:0006694 + steroid biosynthetic process - - - acidity regulator - ChEBI - - - - - acidity regulators - ChEBI - - - - - food acidity regulators - ChEBI - - - - - pH control agent - ChEBI - - - - - pH control agents - ChEBI + + + The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. + GOC:go_curators - + - - - An organic amino compound in which an aminoalkyl group is linked to an arene. - chebi_ontology - aralkylamino compounds - CHEBI:64365 - - aralkylamino compound + + + + + + The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. + bile acid anabolism + bile acid biosynthesis + bile acid formation + bile acid synthesis + biological_process + GO:0006699 + bile acid biosynthetic process - - - aralkylamino compounds - ChEBI + + + The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. + GOC:go_curators - + - - - - A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14. - 0 - C76H104N18O19S2 - InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1 - NHXLMOGPVYXJNR-ATOGVRKGSA-N - 1637.87800 - 1636.71666 - C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)[C@@H](C)O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N - CAS:38916-34-6 - Drug_Central:2997 - HMDB:HMDB0013072 - KEGG:C16022 - KEGG:D07431 - LINCS:LSM-5326 - PMID:21922516 - PMID:22129035 - PMID:22147011 - PMID:22251942 - PMID:22483686 - PMID:22509294 - Reaxys:10148626 - Wikipedia:Somatostatin - L-alanyl-N-[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl]glycinamide - chebi_ontology - Ala-Gly-cyclo-[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys] - L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide - Somatostatin-1 - Somatostatin-14 - Synthetic growth hormone release-inhibiting hormone - somatostatin - somatostatina - somatostatine - somatostatinum - CHEBI:64628 - - somatostatin + + + The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. + The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein. + https://github.com/geneontology/go-ontology/issues/20292 + jl + 2012-12-13T16:25:32Z + GO:0015457 + GO:0015460 + GO:0044765 + small molecule transport + solute:solute exchange + biological_process + single-organism transport + GO:0006810 + + + + + + + + + + Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. + transport - - - CAS:38916-34-6 - ChemIDplus - - - - - CAS:38916-34-6 - KEGG DRUG - - - - - Drug_Central:2997 - DrugCentral - - - - - PMID:21922516 - Europe PMC - - - - - PMID:22129035 - Europe PMC - - - - - PMID:22147011 - Europe PMC - - - - - PMID:22251942 - Europe PMC - - - - - PMID:22483686 - Europe PMC - - - - - PMID:22509294 - Europe PMC - - - - - Reaxys:10148626 - Reaxys - - - - - L-alanyl-N-[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl]glycinamide - IUPAC - - - - - - Ala-Gly-cyclo-[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys] - ChEBI - - - - - L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide - ChemIDplus - - - - - Somatostatin-1 - KEGG_COMPOUND - - - - - Somatostatin-14 - KEGG_COMPOUND - - - - - Synthetic growth hormone release-inhibiting hormone - ChemIDplus - - - - - somatostatin - KEGG_DRUG - - - - - - somatostatina - ChemIDplus - - - - - - somatostatine - ChemIDplus - + + + The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. + GOC:dos + GOC:dph + GOC:jl + GOC:mah - - - somatostatinum - ChemIDplus - + + + The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein. + GOC:dos + GOC:dph + GOC:jl + GOC:mah - + - - - An organic molecular entity containing a single carbon atom (C1). - chebi_ontology - one-carbon compounds - CHEBI:64708 - - one-carbon compound + + + The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0006811 + + + + ion transport - - - one-carbon compounds - ChEBI + + + The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai - + - - - Any organic molecular entity that is acidic and contains carbon in covalent linkage. - chebi_ontology - organic acids - CHEBI:64709 - - organic acid + + + The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GO:0006819 + GO:0015674 + GO:0072512 + di-, tri-valent inorganic cation transport + trivalent inorganic cation transport + biological_process + GO:0006812 + cation transport - - - organic acids - ChEBI + + + The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + + + + + di-, tri-valent inorganic cation transport + GOC:mah - + - - - Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism. - Wikipedia:Poison - chebi_ontology - poisonous agent - poisonous agents - poisonous substance - poisonous substances - poisons - toxic agent - toxic agents - toxic substance - toxic substances - CHEBI:64909 - - poison + + + The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GO:0006822 + biological_process + GO:0006820 + anion transport - - - poisonous agent - ChEBI - - - - - poisonous agents - ChEBI - - - - - poisonous substance - ChEBI - - - - - poisonous substances - ChEBI - - - - - poisons - ChEBI - - - - - toxic agent - ChEBI - - - - - toxic agents - ChEBI - - - - - toxic substance - ChEBI + + + The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + + + + + + + + + + The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. + biological_process + GO:0006837 + serotonin transport + - - - toxic substances - ChEBI + + + The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. + GOC:ai - + - - - - + + - - + + - A carbohydrate derivative that is any derivative of a polysaccharide. - chebi_ontology - polysaccharide derivatives - CHEBI:65212 - - polysaccharide derivative + The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. + biological_process + GO:0006869 + + + + lipid transport - - - polysaccharide derivatives - ChEBI + + + The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. + ISBN:0198506732 - + - - - Substances which are added to food in order to prevent decomposition caused by microbial growth or by undesirable chemical changes. - chebi_ontology - food preservatives - CHEBI:65255 - - food preservative + + + movement of cell or subcellular component - - - - food preservatives - ChEBI - - + - - - - A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299). - chebi_ontology - antimicrobial food preservatives - antimicrobial preservative - antimicrobial preservatives - CHEBI:65256 - - antimicrobial food preservative + + + A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. + Wikipedia:Muscle_contraction + biological_process + GO:0006936 + + muscle contraction - - - antimicrobial food preservatives - ChEBI - - - - - antimicrobial preservative - ChEBI - - - - - antimicrobial preservatives - ChEBI + + + A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. + GOC:ef + GOC:mtg_muscle + ISBN:0198506732 - + - - - + + + + + + + + + + + + + - - + + - An ammonium ion derivative resulting from the protonation of the nitrogen atom of a primary amino compound. Major species at pH 7.3. - +1 - H3NR - 17.031 - 17.02655 - [NH3+][*] - chebi_ontology - a primary amine - substituted ammonium - CHEBI:65296 - - primary ammonium ion + Any process that modulates the frequency, rate or extent of muscle contraction. + biological_process + GO:0006937 + regulation of muscle contraction - - - a primary amine - UniProt - - - - - substituted ammonium - ChEBI + + + Any process that modulates the frequency, rate or extent of muscle contraction. + GOC:go_curators - + - - - Any compound that has anti-inflammatory effects. - chebi_ontology - anti-inflammatory agents - antiinflammatory agent - antiinflammatory agents - CHEBI:67079 - - anti-inflammatory agent + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. + visceral muscle contraction + biological_process + GO:0006939 + smooth muscle contraction - - - anti-inflammatory agents - ChEBI - - - - - antiinflammatory agent - ChEBI - - - - - antiinflammatory agents - ChEBI + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. + GOC:ef + GOC:jl + GOC:mtg_muscle + ISBN:0198506732 - + - - - - - - - - - + + + + + + + + + + + + + - - + + - An organic cation that is the conjugate acid of (R)-noradrenaline, obtained by protonation of the priamry amino group; major species at pH 7.3. - +1 - C8H12NO3 - InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/p+1/t8-/m0/s1 - SFLSHLFXELFNJZ-QMMMGPOBSA-O - 170.187 - 170.08117 - C=1(C=CC(=CC1O)[C@H](C[NH3+])O)O - PDBeChem:E5E - (2R)-2-(3,4-dihydroxyphenyl)-2-hydroxyethanaminium - chebi_ontology - (R)-noradrenaline - (R)-noradrenaline cation - (R)-noradrenalinium cation - (R)-noradrenalinium(1+) - CHEBI:72587 - - (R)-noradrenaline(1+) + Any process that modulates the frequency, rate or extent of smooth muscle contraction. + biological_process + GO:0006940 + regulation of smooth muscle contraction - - - (2R)-2-(3,4-dihydroxyphenyl)-2-hydroxyethanaminium - IUPAC - - - - - - (R)-noradrenaline - UniProt - - - - - (R)-noradrenaline cation - ChEBI - - - - - (R)-noradrenalinium cation - ChEBI - - - - - (R)-noradrenalinium(1+) - ChEBI + + + Any process that modulates the frequency, rate or extent of smooth muscle contraction. + GOC:go_curators - + - - - - Any molecule that consists of at least one carbon atom as part of the electrically neutral entity. - chebi_ontology - organic compound - organic compounds - organic molecules - CHEBI:72695 - - organic molecule + + + + Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. + biological_process + GO:0006955 + + immune response - - - organic compound - ChEBI - - - - - organic compounds - ChEBI - - - - - organic molecules - ChEBI + + + Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. + GOC:add + GO_REF:0000022 - + - - - A biomacromolecule composed of carbohydrate residues which is secreted by a microorganism into the surrounding environment. - MetaCyc:Exopolysaccharides - PMID:11160795 - PMID:11785425 - PMID:1444258 - PMID:15738217 - PMID:16075348 - PMID:17440912 - PMID:18097339 - PMID:19453747 - PMID:20172021 - PMID:20631870 - PMID:20718297 - PMID:2688547 - PMID:6354590 - Wikipedia:Exopolysaccharide - Wikipedia:Extracellular_polymeric_substance - chebi_ontology - exopolysaccharides - extracellular polymeric substance - extracellular polymeric substances - CHEBI:72813 - - exopolysaccharide + + + Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + Wikipedia:Cell_signaling + biological_process + GO:0007154 + + + cell communication - - - PMID:11160795 - Europe PMC - - - - - PMID:11785425 - Europe PMC - - - - - PMID:1444258 - Europe PMC - - - - - PMID:15738217 - Europe PMC - - - - - PMID:16075348 - Europe PMC - - - - - PMID:17440912 - Europe PMC - - - - - PMID:18097339 - Europe PMC - - - - - PMID:19453747 - Europe PMC - - - - - PMID:20172021 - Europe PMC - - - - - PMID:20631870 - Europe PMC - - - - - PMID:20718297 - Europe PMC - - - - - PMID:2688547 - Europe PMC - - - - - PMID:6354590 - Europe PMC - - - - - exopolysaccharides - ChEBI - - - - - extracellular polymeric substance - ChEBI - - - - - extracellular polymeric substances - ChEBI + + + Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:mah - - - - - A mancude heterobicyclic organic group consisting of a benzene ring fused to a pyrrole ring. - 0 - C8N - 110.09230 - 110.00307 - C1(=C(C(=C2C(=C1*)N(C(=C2*)*)*)*)*)* - chebi_ontology - CHEBI:73398 - - indole skeleton - - - - - + - - - A bicyclic organic group that contains both carbon and hetero atoms. - chebi_ontology - organic heterobicyclic rings - CHEBI:73541 - - organic heterobicyclic ring + + + + Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. + cell-cell signalling + biological_process + GO:0007267 + + + cell-cell signaling - - - organic heterobicyclic rings - ChEBI + + + Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. + GOC:dos + GOC:mah - + - - - Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms. - chebi_ontology - eukaryotic metabolites - CHEBI:75763 - - eukaryotic metabolite + + + + The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + https://github.com/geneontology/go-ontology/issues/21234 + biological_process + GO:0007275 + + + + Note that this term was 'developmental process'. + multicellular organism development - - - eukaryotic metabolites - ChEBI + + + The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + GOC:dph + GOC:ems + GOC:isa_complete + GOC:tb - + - - - Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals. - CHEBI:77721 - CHEBI:77743 - chebi_ontology - animal metabolites - CHEBI:75767 - - animal metabolite + + + + + + + + + The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. + GO:0009552 + biological_process + gametogenesis + GO:0007276 + gamete generation - - - animal metabolites - ChEBI + + + The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. + GOC:ems + GOC:mtg_sensu - + - - - Any animal metabolite produced during a metabolic reaction in mammals. - CHEBI:77464 - CHEBI:77744 - chebi_ontology - mammalian metabolites - CHEBI:75768 - - mammalian metabolite + + + + + + + + + + + + + + + + + + + + + A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. + Wikipedia:Gastrulation + biological_process + GO:0007369 + + gastrulation - - - mammalian metabolites - ChEBI + + + A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. + GOC:curators + ISBN:9780878933846 - + - - - Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus). - chebi_ontology - Mus musculus metabolite - Mus musculus metabolites - mouse metabolites - CHEBI:75771 - - mouse metabolite + + + The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. + biological_process + GO:0007398 + ectoderm development - - - Mus musculus metabolite - ChEBI - - - - - Mus musculus metabolites - ChEBI - - - - - mouse metabolites - ChEBI + + + The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. + GOC:dph + GOC:tb - + - - - Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae). - CHEBI:76949 - CHEBI:76951 - chebi_ontology - S. cerevisiae metabolite - S. cerevisiae metabolites - S. cerevisiae secondary metabolite - S. cerevisiae secondary metabolites - Saccharomyces cerevisiae metabolites - Saccharomyces cerevisiae secondary metabolites - baker's yeast metabolite - baker's yeast metabolites - baker's yeast secondary metabolite - baker's yeast secondary metabolites - CHEBI:75772 - - Saccharomyces cerevisiae metabolite + + + The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. + biological_process + pan-neural process + GO:0007399 + + nervous system development - - - S. cerevisiae metabolite - ChEBI - - - - - S. cerevisiae metabolites - ChEBI - - - - - S. cerevisiae secondary metabolite - ChEBI - - - - - S. cerevisiae secondary metabolites - ChEBI - - - - - Saccharomyces cerevisiae metabolites - ChEBI - - - - - Saccharomyces cerevisiae secondary metabolites - ChEBI - - - - - baker's yeast metabolite - ChEBI - - - - - baker's yeast metabolites - ChEBI - - - - - baker's yeast secondary metabolite - ChEBI - - - - - baker's yeast secondary metabolites - ChEBI + + + The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. + GOC:dgh - + - - - Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea. - chebi_ontology - prokaryotic metabolites - CHEBI:75787 - - prokaryotic metabolite + + + The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. + biological_process + GO:0007492 + endoderm development - - - prokaryotic metabolites - ChEBI + + + The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. + GOC:dph + GOC:tb - + - - - Any metabolite produced by metabolism of a xenobiotic compound. - chebi_ontology - xenobiotic metabolites - CHEBI:76206 - - xenobiotic metabolite + + + The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. + biological_process + GO:0007498 + + mesoderm development - - - xenobiotic metabolites - ChEBI + + + The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. + GOC:dph + GOC:tb - + - - - Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*). - Wikipedia:Hydrolase - chebi_ontology - EC 3.* (hydrolase) inhibitors - EC 3.* inhibitor - EC 3.* inhibitors - EC 3.*.*.* inhibitor - EC 3.*.*.* inhibitors - hydrolase (EC 3.*) inhibitor - hydrolase (EC 3.*) inhibitors - hydrolase inhibitor - hydrolase inhibitors - CHEBI:76759 - - EC 3.* (hydrolase) inhibitor + + + The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. + breathing + respiration + biological_process + GO:0007585 + + respiratory gaseous exchange by respiratory system - - - EC 3.* (hydrolase) inhibitors - ChEBI - - - - - EC 3.* inhibitor - ChEBI - - - - - EC 3.* inhibitors - ChEBI - - - - - EC 3.*.*.* inhibitor - ChEBI - - - - - EC 3.*.*.* inhibitors - ChEBI - - - - - hydrolase (EC 3.*) inhibitor - ChEBI - - - - - hydrolase (EC 3.*) inhibitors - ChEBI - - - - - hydrolase inhibitor - ChEBI - - - - - hydrolase inhibitors - ChEBI + + + The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. + ISBN:0198506732 - + - - - Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*). - chebi_ontology - EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor - EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors - EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor - EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors - EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors - EC 3.5.* inhibitor - EC 3.5.* inhibitors - CHEBI:76764 - - EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor + + + The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + Wikipedia:Digestion + biological_process + GO:0007586 + + + digestion - - - EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor - ChEBI - - - - - EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors - ChEBI - - - - - EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor - ChEBI - - - - - EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors - ChEBI - - - - - EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors - ChEBI - - - - - EC 3.5.* inhibitor - ChEBI - - - - - EC 3.5.* inhibitors - ChEBI + + + The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:isa_complete + ISBN:0198506732 - + - - - An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*). - chebi_ontology - EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors - EC 3.5.1.* inhibitor - EC 3.5.1.* inhibitors - non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor - non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors - CHEBI:76807 - - EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor + + + The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. + https://github.com/geneontology/go-ontology/issues/22368 + Wikipedia:Excretion + biological_process + GO:0007588 + + + excretion - - - EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors - ChEBI - - - - - EC 3.5.1.* inhibitor - ChEBI - - - - - EC 3.5.1.* inhibitors - ChEBI - - - - - non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor - ChEBI - - - - - non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors - ChEBI + + + The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. + ISBN:0192801023 - + - - - Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. - CHEBI:75766 - CHEBI:76925 - chebi_ontology - plant metabolites - plant secondary metabolites - CHEBI:76924 - - plant metabolite + + + + The controlled release of a fluid by a cell or tissue in an animal. + biological_process + GO:0007589 + body fluid secretion - - - plant metabolites - ChEBI - - - - - plant secondary metabolites - ChEBI + + + The controlled release of a fluid by a cell or tissue in an animal. + GOC:ai + GOC:dph + GOC:mah + GOC:tb - + - - - Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds. - CHEBI:75765 - CHEBI:76947 - chebi_ontology - fungal metabolites - CHEBI:76946 - - fungal metabolite + + + The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + Wikipedia:Perception + biological_process + GO:0007600 + + sensory perception - - - fungal metabolites - ChEBI + + + The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + GOC:dph - + - - - - Any human metabolite produced by metabolism of a xenobiotic compound in humans. - chebi_ontology - human xenobiotic metabolites - CHEBI:76967 - - human xenobiotic metabolite + + + The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. + Wikipedia:Visual_perception + sense of sight + sensory visual perception + vision + biological_process + GO:0007601 + visual perception - - - human xenobiotic metabolites - ChEBI + + + The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. + GOC:ai - + - - - Any prokaryotic metabolite produced during a metabolic reaction in bacteria. - CHEBI:75760 - CHEBI:76970 - chebi_ontology - CHEBI:76969 - - bacterial metabolite + + + The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. + Wikipedia:Hearing_(sense) + hearing + perception of sound + biological_process + GO:0007605 + sensory perception of sound + + + + The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. + GOC:ai + - + - - - Any bacterial metabolite produced during a metabolic reaction in Escherichia coli. - chebi_ontology - E.coli metabolite - E.coli metabolites - Escherichia coli metabolites - CHEBI:76971 - - Escherichia coli metabolite - - - - - E.coli metabolite - ChEBI - - - - - E.coli metabolites - ChEBI - - - - - Escherichia coli metabolites - ChEBI - - - - - - - - - Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). - CHEBI:75770 - CHEBI:77123 - chebi_ontology - H. sapiens metabolite - H. sapiens metabolites - Homo sapiens metabolite - Homo sapiens metabolites - CHEBI:77746 - - human metabolite - - - - - H. sapiens metabolite - ChEBI - - - - - H. sapiens metabolites - ChEBI - - - - - Homo sapiens metabolite - ChEBI - - - - - Homo sapiens metabolites - ChEBI - - - - - - - - - An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4). - Wikipedia:Amidase - chebi_ontology - EC 3.5.1.4 (amidase) inhibitors - EC 3.5.1.4 inhibitor - EC 3.5.1.4 inhibitors - N-acetylaminohydrolase inhibitor - N-acetylaminohydrolase inhibitors - acylamidase inhibitor - acylamidase inhibitors - acylamide amidohydrolase inhibitor - acylamide amidohydrolase inhibitors - amidase (EC 3.5.1.4) inhibitor - amidase (EC 3.5.1.4) inhibitors - amidase inhibitor - amidase inhibitors - amidohydrolase inhibitor - amidohydrolase inhibitors - deaminase inhibitor - deaminase inhibitors - fatty acylamidase inhibitor - fatty acylamidase inhibitors - CHEBI:77941 - - EC 3.5.1.4 (amidase) inhibitor - - - - - EC 3.5.1.4 (amidase) inhibitors - ChEBI - - - - - EC 3.5.1.4 inhibitor - ChEBI - - - - - EC 3.5.1.4 inhibitors - ChEBI - - - - - N-acetylaminohydrolase inhibitor - ChEBI - - - - - N-acetylaminohydrolase inhibitors - ChEBI - - - - - acylamidase inhibitor - ChEBI - - - - - acylamidase inhibitors - ChEBI - - - - - acylamide amidohydrolase inhibitor - ChEBI - - - - - acylamide amidohydrolase inhibitors - ChEBI - - - - - amidase (EC 3.5.1.4) inhibitor - ChEBI - - - - - amidase (EC 3.5.1.4) inhibitors - ChEBI - - - - - amidase inhibitor - ChEBI - - - - - amidase inhibitors - ChEBI - - - - - amidohydrolase inhibitor - ChEBI - - - - - amidohydrolase inhibitors - ChEBI - - - - - deaminase inhibitor - ChEBI - - - - - deaminase inhibitors - ChEBI - - - - - fatty acylamidase inhibitor - ChEBI - - - - - fatty acylamidase inhibitors - ChEBI - - - - - - - - - A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container. - Wikipedia:Packaging_gas - chebi_ontology - food packaging gases - CHEBI:77974 - - food packaging gas + + + + + The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. + jl + 2012-09-20T14:06:08Z + GO:0023032 + GO:0044708 + GO:0044709 + Wikipedia:Behavior + behavioral response to stimulus + behaviour + behavioural response to stimulus + biological_process + single-organism behavior + GO:0007610 + + + + 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews. +2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis). + behavior - - - food packaging gases - ChEBI + + + The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. + GOC:ems + GOC:jl + ISBN:0395448956 + PMID:20160973 - + - - - A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants. - chebi_ontology - dietary component - dietary components - food components - CHEBI:78295 - - food component + + + The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. + behavior via locomotion + locomotion in response to stimulus + locomotory behavioral response to stimulus + locomotory behaviour + locomotory behavioural response to stimulus + biological_process + GO:0007626 + + locomotory behavior - - - dietary component - ChEBI - - - - - dietary components - ChEBI - - - - - food components - ChEBI + + + The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. + GOC:dph - + - - - A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a "R" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure. - Wikipedia:Refrigerant - chebi_ontology - refrigerants - CHEBI:78433 - - refrigerant + + + The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. + GO:0070261 + biological_process + hemolymph circulation + GO:0008015 + + blood circulation - - - refrigerants - ChEBI + + + The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. + GOC:mtg_heart + ISBN:0192800825 - + - - + + + + + + + + + + + + + - - + + - An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3. - 0 - C2H4NO2R - 74.059 - 74.02420 - [NH3+]C([*])C([O-])=O - CHEBI:83409 - MetaCyc:Alpha-Amino-Acids - chebi_ontology - an alpha-amino acid - CHEBI:78608 - - alpha-amino acid zwitterion - - - - - MetaCyc:Alpha-Amino-Acids - SUBMITTER - - - - - an alpha-amino acid - UniProt - - - - - - - - - Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation. - chebi_ontology - carbohydrates and derivatives - carbohydrates and their derivatives - CHEBI:78616 - - carbohydrates and carbohydrate derivatives + Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. + regulation of cardiac contraction + biological_process + GO:0008016 + regulation of heart contraction - - - carbohydrates and derivatives - ChEBI - - - - - carbohydrates and their derivatives - ChEBI + + + Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. + GOC:dph + GOC:go_curators + GOC:tb - + - - - Any metabolite produced by all living cells. - chebi_ontology - essential metabolite - essential metabolites - fundamental metabolites - CHEBI:78675 - - fundamental metabolite + + + Any process in which a protein is transported to, or maintained in, a specific location. + https://github.com/geneontology/go-ontology/issues/23112 + GO:0008105 + GO:0016249 + GO:0034613 + cellular protein localisation + cellular protein localization + protein localisation + channel localizer activity + biological_process + asymmetric protein localisation + asymmetric protein localization + establishment and maintenance of asymmetric protein localization + establishment and maintenance of protein localization + GO:0008104 + + protein localization - - - essential metabolite - ChEBI - - - - - essential metabolites - ChEBI + + + Any process in which a protein is transported to, or maintained in, a specific location. + GOC:ai - - - fundamental metabolites - ChEBI + + + cellular protein localisation + GOC:mah - - - - - - - - Any inorganic anion with a valency of three. - chebi_ontology - trivalent inorganic anions - CHEBI:79387 - - trivalent inorganic anion - - - - trivalent inorganic anions - ChEBI + + + protein localisation + GOC:mah - - - - - - - - Any inorganic anion with a valency of two. - chebi_ontology - divalent inorganic anions - CHEBI:79388 - - divalent inorganic anion - - - - divalent inorganic anions - ChEBI + + + channel localizer activity + GOC:mah - - - - - - - - Any inorganic anion with a valency of one. - chebi_ontology - monovalent inorganic anions - CHEBI:79389 - - monovalent inorganic anion - - + - monovalent inorganic anions - ChEBI + asymmetric protein localisation + GOC:mah - + - - - An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill. - chebi_ontology - crustacean metabolites - CHEBI:83039 - - crustacean metabolite + + + A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. + jl + 2012-09-19T15:05:24Z + GO:0000004 + GO:0007582 + GO:0044699 + Wikipedia:Biological_process + biological process + physiological process + biological_process + single organism process + single-organism process + GO:0008150 + + + + + + + + + + Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. + biological_process - - - crustacean metabolites - ChEBI + + + A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. + GOC:pdt - + - - - A Daphnia metabolite produced by the species Daphnia magna. - chebi_ontology - Daphnia magna metabolites - CHEBI:83056 - - Daphnia magna metabolite + + + + The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. + jl + 2012-10-17T15:46:40Z + GO:0044236 + GO:0044710 + Wikipedia:Metabolism + metabolism + metabolic process resulting in cell growth + metabolism resulting in cell growth + multicellular organism metabolic process + biological_process + single-organism metabolic process + GO:0008152 + + + + + + Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. + metabolic process - - - Daphnia magna metabolites - ChEBI + + + The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. + GOC:go_curators + ISBN:0198547684 - + - - - A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia - Wikipedia:Daphnia - chebi_ontology - Daphnia metabolites - CHEBI:83057 - - Daphnia metabolite + + + + The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + Wikipedia:Steroid_metabolism + steroid metabolism + biological_process + GO:0008202 + steroid metabolic process - - - Daphnia metabolites - ChEBI + + + The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + ISBN:0198547684 - - - - - - Any member of the class of indoles carrying at least one hydroxy group. - chebi_ontology - CHEBI:84729 - - hydroxyindoles - - - - - + - - - Any eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae. - chebi_ontology - algal metabolites - CHEBI:84735 - - algal metabolite + + + + + The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. + bile acid metabolism + biological_process + GO:0008206 + bile acid metabolic process - - - algal metabolites - ChEBI + + + The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. + GOC:go_curators - + - - + + - - + + + + + + - - - - A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. - CALOHA:TS-2035 - FBbt:00007002 - FMA:68646 - GO:0005623 - KUPO:0000002 - MESH:D002477 - VHOG:0001533 - WBbt:0004017 - XAO:0003012 - - The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). - cell + + + + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + + biological_process + cell proliferation + GO:0008283 + + + + + + + This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. + cell population proliferation - + - A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. - CARO:mah + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + GOC:mah + GOC:mb - + - + - + - - + + - - + + - - + + + + + + - - + + - Any fibroblast that is deriived from the neural crest. - fibroblast neural crest derived + + + + + + + Any process that activates or increases the rate or extent of cell proliferation. + + up regulation of cell proliferation + up-regulation of cell proliferation + upregulation of cell proliferation + activation of cell proliferation + stimulation of cell proliferation + biological_process + positive regulation of cell proliferation + GO:0008284 + positive regulation of cell population proliferation - + - Any fibroblast that is deriived from the neural crest. - https://orcid.org/0000-0001-5208-3432 + Any process that activates or increases the rate or extent of cell proliferation. + GOC:go_curators - + - + - - + - - + + - - + + - - + + + + + + - neuronal receptor cell (sensu Animalia) - neuronal receptor cell + + + + + + + + + + + + + Any process that stops, prevents or reduces the rate or extent of cell proliferation. + + down regulation of cell proliferation + down-regulation of cell proliferation + downregulation of cell proliferation + inhibition of cell proliferation + biological_process + negative regulation of cell proliferation + GO:0008285 + negative regulation of cell population proliferation + + + + Any process that stops, prevents or reduces the rate or extent of cell proliferation. + GOC:go_curators + - + - - - A cell found in the embryo before the formation of all the gem layers is complete. - early embryonic cell (metazoa) + + + + The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. + lipid anabolism + lipid biosynthesis + lipid formation + lipid synthesis + lipogenesis + biological_process + GO:0008610 + lipid biosynthetic process - + - A cell found in the embryo before the formation of all the gem layers is complete. - GOC:tfm + The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. + GOC:go_curators + + + + + lipogenesis + GOC:sl - + - - - Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination. - migratory cranial neural crest cell + + + The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. + jl + 2012-10-17T15:52:35Z + GO:0044243 + GO:0044712 + Wikipedia:Catabolism + breakdown + catabolism + degradation + multicellular organismal catabolic process + biological_process + single-organism catabolic process + GO:0009056 + + + + catabolic process - + - Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination. - ZFA:0007091 - https://orcid.org/0000-0001-5208-3432 + The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. + ISBN:0198547684 - + - - - Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination. - migratory trunk neural crest cell + + + + The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GO:0043285 + GO:0044266 + biopolymer catabolic process + macromolecule breakdown + macromolecule catabolism + macromolecule degradation + multicellular organismal macromolecule catabolic process + biological_process + GO:0009057 + + macromolecule catabolic process - + - Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination. - ZFA:0007095 - https://orcid.org/0000-0001-5208-3432 + The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:mah + + + + + biopolymer catabolic process + GOC:mtg_chebi_dec09 - + - - - - - - - - - - - - - - - - - - - - - A stem cell that is the precursor of gametes. - FBbt:00004861 - germline stem cell - germ line stem cell + + + The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. + jl + 2012-10-17T15:52:18Z + GO:0044274 + GO:0044711 + formation + Wikipedia:Anabolism + anabolism + biosynthesis + synthesis + multicellular organismal biosynthetic process + biological_process + single-organism biosynthetic process + GO:0009058 + + + + biosynthetic process - - - - true - - - + - A stem cell that is the precursor of gametes. - doi:10.1016/j.stem.2012.05.016 + The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. + GOC:curators + ISBN:0198547684 - + - - - - - - - - - - - - - - - - - - - - Female germ cell is a germ cell that supports female gamete production. - MA:0000388 - VHOG:0001530 - ncithesaurus:Egg - female germ cell + + + + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GO:0043284 + biopolymer biosynthetic process + macromolecule anabolism + macromolecule biosynthesis + macromolecule formation + macromolecule synthesis + biological_process + GO:0009059 + + macromolecule biosynthetic process - - - - true + + + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:mah - - - Female germ cell is a germ cell that supports female gamete production. - GOC:tfm - PMID:11023867 - PMID:20454446 + + + biopolymer biosynthetic process + GOC:mtg_chebi_dec09 - + - - - - - - - - - - - - - - - - - - - - - A stem cell that is the precursor of female gametes. - FBbt:00004873 - female germ line stem cell + + + + The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. + glucan anabolism + glucan biosynthesis + glucan formation + glucan synthesis + biological_process + GO:0009250 + glucan biosynthetic process - - - - true - - - - - - true - - - + - A stem cell that is the precursor of female gametes. - doi:10.1016/j.stem.2012.05.016 + The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. + GOC:go_curators - + - - - - - - - - - - - - - - - - A female germ cell that has entered meiosis. - BTO:0000964 - CALOHA:TS-0711 - FBbt:00004886 - FMA:18644 - MESH:D009865 - WBbt:0006797 - oogonium - oocyte + + + + The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues. + glucan breakdown + glucan catabolism + glucan degradation + biological_process + GO:0009251 + glucan catabolic process - - - - true - - - + - A female germ cell that has entered meiosis. - GOC:tfm - ISBN:0721662544 + The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues. + GOC:go_curators - + - - - - - - - - - - - - - - - - - - - - - - - - - - An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes. - FMA:83673 - oogonial cell + + + + + The controlled release of proteins from a cell. + GO:0045166 + GO:0045731 + glycoprotein secretion + protein secretion during cell fate commitment + protein secretion resulting in cell fate commitment + biological_process + GO:0009306 + protein secretion - - - - true - - - + - An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes. - GOC:tfm - ISBN:0721662544 + The controlled release of proteins from a cell. + GOC:ai - + - - - - - - - - - - - - - - - A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization. - BTO:0000369 - BTO:0003801 - CALOHA:TS-2191 - FBbt:00057012 - FMA:67343 - MA:0000388 - MESH:D010063 - mature oocyte - ovum - egg cell - https://www.swissbiopics.org/api/image/Egg_cell.svg + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. + response to electromagnetic radiation stimulus + response to radiation stimulus + biological_process + GO:0009314 + Note that 'radiation' refers to electromagnetic radiation of any wavelength. + response to radiation - - - - true - - - + - A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization. - GOC:tfm - ISBN:0721662544 + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. + GOC:jl + Wikipedia:Electromagnetic_radiation - + - - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell derived from the neural crest. - smooth muscle cell neural crest derived + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. + biological_process + GO:0009416 + + response to light stimulus - - - - true - - - + - A smooth muscle cell derived from the neural crest. - https://orcid.org/0000-0001-5208-3432 + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. + GOC:go_curators + ISBN:0582227089 - + - - - - - - - - - - - - - - - - - - - - - - - - - - - neuron neural crest derived - neural crest derived neuron + + + + The series of events in which an external stimulus is received by a cell and converted into a molecular signal. + biological_process + perception of external stimulus + GO:0009581 + detection of external stimulus - - - - true + + + The series of events in which an external stimulus is received by a cell and converted into a molecular signal. + GOC:hb - + - - - - - - - - - - A cell that will develop into a neuron often after a migration phase. - BTO:0000930 - FMA:70563 - neuroblast - neuroblast (sensu Vertebrata) + + + + The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. + biological_process + perception of abiotic stimulus + GO:0009582 + detection of abiotic stimulus - + - A cell that will develop into a neuron often after a migration phase. - GOC:NV - http://en.wikipedia.org/wiki/Neuroblast + The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. + GOC:hb - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. - - CALOHA:TS-2086 - FMA:63368 - animal stem cell - - - This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’. - stem cell + + + + + The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. + detection of light + biological_process + perception of light + GO:0009583 + detection of light stimulus - + - A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. - GOC:tfm - MESH:D013234 + The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. + GOC:go_curators - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A stem cell that self-renews as well as give rise to a single mature cell type. - FMA:70569 - unipotent stem cell - unipotential stem cell - single fate stem cell + + + The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. + biological_process + perception of visible light + GO:0009584 + detection of visible light - + - A stem cell that self-renews as well as give rise to a single mature cell type. - GOC:tfm + The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. + GOC:go_curators + ISBN:0198506732 - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. - - BTO:0000725 - CALOHA:TS-0448 - FMA:70337 - FMA:86475 - MESH:D006412 - VHOG:0001485 - blood forming stem cell - hemopoietic stem cell - HSC - colony forming unit hematopoietic - - - Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. - hematopoietic stem cell + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. + response to environmental stimulus + biological_process + GO:0009605 + + + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + response to external stimulus - - - - true - - - + - A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. - GOC:add - GOC:dsd - GOC:tfm - PMID:19022770 - http://en.wikipedia.org/wiki/Hematopoietic_stem_cell + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. + GOC:hb + + + + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. + https://github.com/geneontology/go-ontology/issues/16572 + response to abiotic stress + biological_process + GO:0009628 + + + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + response to abiotic stimulus + - - - HSC - + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. + GOC:hb - + - - - + + - - + + - A progenitor cell committed to the erythroid lineage. - BTO:0004911 - BFU-E - CFU-E - blast forming unit erythroid - burst forming unit erythroid - colony forming unit erythroid - erythroid stem cell - - erythroid progenitor cell + The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. + embryogenesis and morphogenesis + Wikipedia:Morphogenesis + anatomical structure organization + morphogenesis + biological_process + GO:0009653 + anatomical structure morphogenesis - - - - true - - - + - A progenitor cell committed to the erythroid lineage. - GOC:add - ISBN:0721601464 - - - - - BFU-E - - - - - - CFU-E - + The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. + GOC:go_curators + ISBN:0521436125 - + - - - - - - - - - A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring. - - - Originally this term had some plant germ line cell children. - germ line cell + + + The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. + GO:0009795 + embryogenesis and morphogenesis + Wikipedia:Embryogenesis + embryogenesis + embryonal development + biological_process + GO:0009790 + + + + embryo development - + - A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring. - GOC:tfm - ISBN:0721662544 + The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. + GOC:go_curators + GOC:isa_complete + GOC:mtg_sensu - + - - - - - - - - - - - - - - - - - - - - - - - + + - - + + - A stem cell that can give rise to multiple lineages of cells. - FMA:84789 - multi-fate stem cell - multifate stem cell - multipotent cell - multipotent stem cell - multi fate stem cell + The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. + biological_process + GO:0009791 + + post-embryonic development - + - A stem cell that can give rise to multiple lineages of cells. - GOC:add + The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. + GOC:go_curators - + - - - - A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. - - BTO:0004730 - common myeloid precursor - CFU-GEMM - CFU-S - CMP - colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte - multipotential myeloid stem cell - myeloid stem cell - pluripotent stem cell (bone marrow) - - This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059). - common myeloid progenitor + + + The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. + embryogenesis + biological_process + GO:0009792 + embryo development ending in birth or egg hatching - - - - true - - - + - A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. - GOC:add - ISBN:0878932437 - MESH:D023461 - - - - - CFU-GEMM - ISBN:0878932437 - - - - - - CFU-S - ISBN:0878932437 - - - - - - CMP - ISBN:0878932437 - - - - - - colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte - ISBN:0878932437 - - - - - multipotential myeloid stem cell - ISBN:0878932437 - - - - - myeloid stem cell - ISBN:0878932437 - - - - - pluripotent stem cell (bone marrow) - ISBN:0878932437 + The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. + GOC:go_curators + GOC:isa_complete + GOC:mtg_sensu - + - - - - - - - - - - - - - - - - - - - + + - - + + + + + + - - + + + + + + - - + + + + + + - A progenitor cell committed to the megakaryocyte and erythroid lineages. - - CFU-EM - CFU-MegE - MEP - Meg/E progenitor - colony forming unit erythroid megakaryocyte - megakaryocyte/erythrocyte progenitor - megakaryocyte/erythroid progenitor cell - - MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. - megakaryocyte-erythroid progenitor cell - - - - - - true - - - - - A progenitor cell committed to the megakaryocyte and erythroid lineages. - GOC:add - GOC:dsd - GOC:tfm - MESH:D055015 - PMID:16647566 - http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell - - - - - - - - - A stem cell from which all cells of the body can form. - FMA:84790 - MESH:D039901 - totipotential stem cell - totipotent stem cell - - - - - A stem cell from which all cells of the body can form. - GOC:add - GOC:tfm - - - - - - - - - - + + + + + + - A precursor cell with a limited number of potential fates. - BTO:0000125 - FMA:84782 - blast cell - define using PATO mulit-potent or oligopotent? - non-terminally differentiated cell + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. + + + + + + histogenesis and organogenesis + Wikipedia:Histogenesis + histogenesis + biological_process + GO:0009888 + tissue development - + - A precursor cell with a limited number of potential fates. - SANBI:mhl + The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. + ISBN:0471245208 - + - - - A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair. - BTO:0000222 - CALOHA:TS-0650 - FBbt:00005083 - FMA:70335 - VHOG:0001529 - myoblast + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. + regulation of anabolism + regulation of biosynthesis + regulation of formation + regulation of synthesis + biological_process + GO:0009889 + regulation of biosynthetic process - + - A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair. - GOC:tfm - MESH:D032446 - PMID:21849021 + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. + GOC:go_curators - + - - + + + + + + + + + + + + + + - - + + - A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped. - - BTO:0000452 - CALOHA:TS-0362 - FMA:63877 - NCIT:C12482 - VHOG:0001482 - - - These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. - fibroblast + Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. + down regulation of biosynthetic process + down-regulation of biosynthetic process + downregulation of biosynthetic process + negative regulation of anabolism + negative regulation of biosynthesis + negative regulation of formation + negative regulation of synthesis + inhibition of biosynthetic process + biological_process + GO:0009890 + negative regulation of biosynthetic process - + - A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped. - ISBN:0517223651 - MESH:D005347 - http://en.wikipedia.org/wiki/Fibroblast + Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. + GOC:go_curators - + - - - - - - - - - + + + + + + + + + + + + + + - - + + - Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell. - BTO:0003607 - FMA:66783 - chrondoplast - chondroblast + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. + positive regulation of anabolism + positive regulation of biosynthesis + positive regulation of formation + positive regulation of synthesis + up regulation of biosynthetic process + up-regulation of biosynthetic process + upregulation of biosynthetic process + activation of biosynthetic process + stimulation of biosynthetic process + biological_process + GO:0009891 + positive regulation of biosynthetic process - + - Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell. - GOC:tfm - GO_REF:0000034 - ISBN:0618947256 + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. + GOC:go_curators - + - + - + - - + + - - + + - - + + - A cell that has a filiform extrusion of the cell surface. - VHOG:0001532 - XAO:0000031 - ciliated cell + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GO:0044252 + down regulation of metabolic process + down-regulation of metabolic process + downregulation of metabolic process + negative regulation of metabolism + negative regulation of organismal metabolism + inhibition of metabolic process + inhibition of organismal metabolic process + negative regulation of multicellular organismal metabolic process + biological_process + GO:0009892 + negative regulation of metabolic process - + - A cell that has a filiform extrusion of the cell surface. - GOC:tfm + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GOC:go_curators - + - - + + + + + + + + + + + + + + - - + + - - A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina. - - BTO:0000414 - CALOHA:TS-2026 - CARO:0000077 - FBbt:00000124 - FMA:66768 - WBbt:0003672 - epitheliocyte - - - epithelial cell - https://www.swissbiopics.org/api/image/Epithelial_cells.svg + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GO:0044253 + positive regulation of metabolism + up regulation of metabolic process + up-regulation of metabolic process + upregulation of metabolic process + activation of metabolic process + positive regulation of multicellular organismal metabolic process + positive regulation of organismal metabolism + stimulation of metabolic process + stimulation of organismal metabolic process + up-regulation of organismal metabolic process + biological_process + GO:0009893 + positive regulation of metabolic process - + - A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina. - FB:ma - GOC:tfm - MESH:D004847 + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GOC:go_curators - + - + - + - - + + - - + - - + + - An epithelial cell that has a cilia. - FMA:70605 - ciliated epithelial cell + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. + regulation of breakdown + regulation of catabolism + regulation of degradation + biological_process + GO:0009894 + regulation of catabolic process - + - An epithelial cell that has a cilia. - GOC:tfm + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. + GOC:go_curators - + - + - + - - + + - + + - - + + - An epithelial cell that is part of a duct. - duct epithelial cell + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. + down regulation of catabolic process + down-regulation of catabolic process + downregulation of catabolic process + negative regulation of breakdown + negative regulation of catabolism + negative regulation of degradation + inhibition of catabolic process + biological_process + GO:0009895 + negative regulation of catabolic process - + - An epithelial cell that is part of a duct. - https://orcid.org/0000-0001-5208-3432 + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. + GOC:go_curators - - - - - branched duct epithelial cell - - - - - + - + - + - - + + - - - - - - - - + + - - + + - An endothelial cell that lines the vasculature. - - cuboidal endothelial cell of vascular tree - - blood vessel endothelial cell + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. + positive regulation of breakdown + positive regulation of catabolism + positive regulation of degradation + up regulation of catabolic process + up-regulation of catabolic process + upregulation of catabolic process + activation of catabolic process + stimulation of catabolic process + biological_process + GO:0009896 + positive regulation of catabolic process - - - - true - - - + - An endothelial cell that lines the vasculature. - GOC:tfm + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. + GOC:go_curators - + - - - A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. - - - columnar/cuboidal epithelial cell + + + + The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0009914 + + hormone transport - + - A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. - GO:0002065 - https://orcid.org/0000-0001-5208-3432 + The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:tb - + - - - CALOHA:TS-1249 - squamous epithelial cell + + + Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + jl + 2012-12-11T16:56:55Z + GO:0008151 + GO:0044763 + GO:0050875 + cell physiology + cellular physiological process + cell growth and/or maintenance + biological_process + single-organism cellular process + GO:0009987 + + + cellular process + + + + Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GOC:go_curators + GOC:isa_complete + - + - - - - - - - - - - - A flattened epithelial cell of mesenchymal origin that lines the serous cavity. - - FMA:66773 - mesotheliocyte - - mesothelial cell + + + The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + biological_process + GO:0010463 + mesenchymal cell proliferation - + - A flattened epithelial cell of mesenchymal origin that lines the serous cavity. - GOC:tfm - ISBN:0721662544 + The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + GOC:dph + GOC:tb - + - + - + - - + + - + - - + + - A cell which moves among different tissues of the body, via blood, lymph, or other medium. - circulating cell + Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + biological_process + GO:0010464 + regulation of mesenchymal cell proliferation - + - A cell which moves among different tissues of the body, via blood, lymph, or other medium. - GOC:add + Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + GOC:dph + GOC:tb - + - + - + - - + + - + + - - + + - A cell found predominately in the blood. - FMA:62844 - MESH:D001773 - - blood cell + Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. + biological_process + GO:0010470 + regulation of gastrulation - - - - true - - - + - A cell found predominately in the blood. - GOC:add - GOC:tfm + Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. + GOC:dph + GOC:tb - + - + - + - - + + - - - - - - - - + + - - + + - An epithelial cell of the lung. - BTO:0004299 - lung epithelial cell - epithelial cell of lung + Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + biological_process + GO:0010556 + regulation of macromolecule biosynthetic process - + - An epithelial cell of the lung. - https://orcid.org/0000-0001-5208-3432 + Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb - + - + - + - - + + - - - - - - - - + + + - - + + - An epithelial cell of the pancreas. - BTO:0000028 - pancreas epithelial cell - pancreatic epithelial cell - epithelial cell of pancreas + Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + biological_process + GO:0010557 + positive regulation of macromolecule biosynthetic process - + - An epithelial cell of the pancreas. - GOC:tfm + Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb - - - - - - - - - - - - neuron associated cell - - - - - + - + - + - - + + - - + + + - - + + - A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells. - neuroepithelial cell - BTO:0004301 - The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710). - sensory epithelial cell - - - - - A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells. - GOC:tfm - ISBN:0517223651 - ISBN:0721662544 - - - - - - - - - Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions. - - BTO:0003811 - FBbt:00005125 - FMA:67313 - WBbt:0005113 - - interneuron - - - - - Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions. - GOC:tfm - MESH:D007395 - - - - - - - - - An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement. - - BTO:0000312 - FBbt:00005123 - FMA:83617 - WBbt:0005409 - motoneuron - - motor neuron + Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + biological_process + GO:0010558 + negative regulation of macromolecule biosynthetic process - + - An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement. - MESH:D009046 - PMID:16875686 + Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb - + - + - + - - + + - + + - - + + - Any neuron having a sensory function; an afferent neuron conveying sensory impulses. - BTO:0001037 - FBbt:00005124 - FMA:84649 - MESH:D011984 - WBbt:0005759 - sensory neuron + Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + biological_process + GO:0010565 + regulation of cellular ketone metabolic process - + - Any neuron having a sensory function; an afferent neuron conveying sensory impulses. - ISBN:0721662544 + Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + GOC:dph + GOC:tb - + - + - + - - + + - - - - - - - + + - - + + - A neuron whose cell body is within an autonomic ganglion. - FMA:80121 - autonomic neuron + Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + biological_process + GO:0010604 + positive regulation of macromolecule metabolic process - + - A neuron whose cell body is within an autonomic ganglion. - GOC:tfm + Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb - + - + - + - - + + - - + + - - + + - A neuron that uses acetylcholine as a vesicular neurotransmitter. - BTO:0004902 - FBbt:00007173 - FMA:84796 - MESH:D059329 - WBbt:0006840 - cholinergic neuron - - - - - A neuron that uses acetylcholine as a vesicular neurotransmitter. - GOC:tfm - - - - - - - - - - An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm. - - BTO:0001176 - CALOHA:TS-0278 - FMA:66772 - endotheliocyte - - From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]. - endothelial cell + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + biological_process + GO:0010605 + negative regulation of macromolecule metabolic process - + - An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm. - GOC:tfm - MESH:D042783 - PMID:21275341 - http://en.wikipedia.org/wiki/Endothelial_cell - https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855 + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb - + - - - - - - - - - + + + + + + + + + + + + + - - + + - CNS neuron (sensu Vertebrata) - - - - - - - - - A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons. - - BTO:0002606 - CALOHA:TS-0415 - FBbt:00005144 - FMA:54536 - neuroglial cell - neuroglia - - - Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571 - glial cell - - - - - A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons. - MESH:D009457 - - - - - - - - - Ectoderm destined to be nervous tissue. - neurectoderm cell - neurectodermal cell - - - - - Ectoderm destined to be nervous tissue. - GOC:tfm - ISBN:068340007X - - - - - - - - - - A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs. - BTO:0002625 - BTO:0003298 - FMA:70546 - bone marrow stromal cells - colony-forming unit-fibroblast - marrow stromal cells - BMSC - CFU-F - MSC - mesenchymal precursor cell - mesenchymal progenitor cells - mesenchymal stem cell - mesenchymal stromal cell - mesenchymal stromal cells - stem cells, mesenchymal - Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. - mesenchymal stem cell - https://github.com/obophenotype/cell-ontology/issues/474 + Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + biological_process + GO:0010646 + regulation of cell communication - - - - true - - - + - A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs. - FB:ma - GOC:dsd - PMCID:PMC2613570 - PMID:10102814 - PMID:16923606 - PMID:17986482 - PMID:19960544 - http://en.wikipedia.org/wiki/Mesenchymal_stem_cell - http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells - - - - - marrow stromal cells - PMID:11378515 - - - - - BMSC - - - - - - CFU-F - - - - - - MSC - PMID:11378515 - - - - - - mesenchymal progenitor cells - MESH:D044982 - - - - - - mesenchymal stromal cells - - - - - - stem cells, mesenchymal - MESH:D044982 - + Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:dph + GOC:tb - + - - - + + + + + + + + + + + + + + - - + + - A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides. - - BTO:0000443 - CALOHA:TS-0012 - FMA:63880 - adipocyte - adipose cell - - - fat cell + Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + biological_process + GO:0010647 + positive regulation of cell communication - + - A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides. - MESH:D017667 + Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:dph + GOC:tb - + - - - - - - - - - + + + + + + + + + + + + + + - - + + - Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell. - BTO:0000249 - CALOHA:TS-0138 - FMA:66782 - cartilage cell - chondrocyte - - - - - Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell. - GO_REF:0000034 - MESH:D019902 - - - - - - - - - A pigment cell is a cell that contains pigment granules. - VHOG:0001678 - chromatocyte - chromatophore - pigment cell + Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + biological_process + GO:0010648 + negative regulation of cell communication - + - A pigment cell is a cell that contains pigment granules. - GOC:tfm + Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:dph + GOC:tb - - - - - pigment cell - visual pigment cell - - - - - + - - - + + + + + + + + + + + + + + - - + + - A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules. - CALOHA:TS-2085 - FMA:86494 - glandular epithelial cell + Any process that modulates the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + biological_process + GO:0010675 + regulation of cellular carbohydrate metabolic process - + - A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules. - GOC:tfm + Any process that modulates the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + GOC:dph + GOC:tb - + - + - + - - + + - + + + - - + + - A cell that specializes in controlled release of one or more substances. - BTO:0003659 - FMA:86916 - secretory cell + Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + biological_process + GO:0010676 + positive regulation of cellular carbohydrate metabolic process - + - A cell that specializes in controlled release of one or more substances. - GOC:tfm - ISBN:0721662544 + Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + GOC:dph + GOC:tb - + - + - + - - + + - + + + - - + + - A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct. - FMA:16014 - - exocrine cell - - - - - A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct. - ISBN:0198547684 - - - - - - - - - - A cell that secretes glycosaminoglycans. - GAG secreting cell - hyaluronic acid secreting cell - glycosaminoglycan secreting cell + Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + biological_process + GO:0010677 + negative regulation of cellular carbohydrate metabolic process - + - A cell that secretes glycosaminoglycans. - GOC:tfm + Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + GOC:dph + GOC:tb - + - + - + - - + + - + + + - - + + - protein secreting cell - - - - - - - - - seromucus secreting cell + Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine. + biological_process + GO:0010700 + negative regulation of norepinephrine secretion + + + + Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine. + GOC:dph + GOC:tb + - + - + - + - - - - - - - - - - - - + + - - - - - - - + + + - - - - - - - - - - - - + + - A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions. - - FMA:83809 - endocrinocyte - - - endocrine cell + Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. + biological_process + GO:0010701 + positive regulation of norepinephrine secretion - + - A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions. - MESH:D055098 + Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. + GOC:dph + GOC:tb - + - - - - An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas. - BTO:0003865 - FMA:62930 - MESH:D019858 - enteroendocrine cell + + + Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. + biological_process + GO:0010817 + regulation of hormone levels - + - An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas. - GOC:tfm - SANBI:mhl + Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. + GOC:BHF + GOC:dph + GOC:tb - + - + + + Any process in which a lipid is transported to, or maintained in, a specific location. + lipid localisation + biological_process + GO:0010876 + lipid localization + + + + + Any process in which a lipid is transported to, or maintained in, a specific location. + GOC:BHF + GOC:dph + GOC:tb + + + + + lipid localisation + GOC:mah + + + + + + + - + - - + + - - - + + + - - + + - A neuron that is capable of some hormone secretion in response to neuronal signals. - - BTO:0002691 - FBbt:00005130 - FMA:83810 - neurosecretory cell - neurosecretory neuron - - The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. - -The modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron. - neuroendocrine cell + Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + biological_process + GO:0010893 + positive regulation of steroid biosynthetic process - + - A neuron that is capable of some hormone secretion in response to neuronal signals. - MESH:D055099 - - - - - The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. - -The modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron. - PMID:5342440 - https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780323555968000073 + Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + GOC:tb - + - + - + - - + + - + + + - - + + - peptide hormone secreting cell + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + biological_process + GO:0010894 + negative regulation of steroid biosynthetic process + + + + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + GOC:BHF + GOC:tb + - + - + - + - - + + - - + + - - + + - BTO:0000783 - insulin secreting cell + Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. + regulation of glucose metabolism + biological_process + GO:0010906 + regulation of glucose metabolic process + + + + Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. + GOC:BHF + GOC:tb + + + + + regulation of glucose metabolism + GOC:tb + - + - + - - - - - + - - + + - - - - - - - - - - - - - - - + + + - - + + - A cell that secretes insulin and is located towards the center of the islets of Langerhans. - - beta cell - BTO:0000783 - EV:0200009 - FMA:70586 - MA:0002419 - ncithesaurus:Beta_Cell - B-cell of pancreatic islet - beta cell of pancreatic islet - insulin-secreting cell - pancreatic B cell - pancreatic B-cell - pancreatic beta cell - pancreatic islet core - type B enteroendocrine cell - beta cell islet - - Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. - type B pancreatic cell + Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. + positive regulation of glucose metabolism + biological_process + GO:0010907 + positive regulation of glucose metabolic process - - - - true - - - - - - true - - - + - A cell that secretes insulin and is located towards the center of the islets of Langerhans. - GOC:tfm - ISBN:0517223651 - http://en.wikipedia.org/wiki/Pancreatic_b_cell - - - - - beta cell - ZFA:0009102 - - - - - B-cell of pancreatic islet - FMA:70586 - - - - - beta cell of pancreatic islet - FMA:70586 - - - - - insulin-secreting cell - FMA:70586 - - - - - pancreatic B-cell - FMA:70586 - - - - - pancreatic beta cell - FMA:70586 - - - - - pancreatic islet core - MA:0002419 + Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. + GOC:BHF + GOC:tb - + - type B enteroendocrine cell - FMA:70586 - - - - - beta cell islet - MA:0002419 + positive regulation of glucose metabolism + GOC:tb - + - + - + - - + + - + + + - - + + - A cell that secretes glucagon. - FMA:84045 - glucagon-secreting cell - glucagon secreting cell + Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. + tb + 2009-05-11T12:17:53Z + biological_process + GO:0010962 + regulation of glucan biosynthetic process - + - A cell that secretes glucagon. - GOC:tfm + Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. + GOC:dph + GOC:tb - + - + - + - + - - - - - - - - + - - - - - - - - - - - - - + - A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon. - - BTO:0000990 - FMA:70585 - MESH:D050416 - alpha cell of islet of Langerhans - pancreatic alpha cell - - pancreatic A cell + The lipid bilayer surrounding any membrane-bounded vesicle in the cell. + NIF_Subcellular:sao1153182838 + cellular_component + GO:0012506 + vesicle membrane - + - A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon. - GOC:tfm - ISBN:0721662544 + The lipid bilayer surrounding any membrane-bounded vesicle in the cell. + GOC:mah + GOC:vesicle - + - + - + - - + + - + + - - + + - somatostatin secreting cell + Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. + regulation of noradrenaline secretion + biological_process + GO:0014061 + regulation of norepinephrine secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. + GOC:ef + - + - + - + - - + + - - - - - - - - - - - - - - + + - - + + - A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin. - - BTO:0000803 - FMA:70587 - D-cell of pancreatic islet - delta cell of islet - delta cell of pancreatic islet - pancreatic D-cell - pancreatic delta cell - somatostatin-secreting pancreatic cell - - pancreatic D cell + Any process that modulates the frequency, rate or extent of the regulated release of serotonin. + biological_process + regulation of serotonin release + GO:0014062 + regulation of serotonin secretion - + - A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin. - FMA:0517223651 - GOC:tfm + Any process that modulates the frequency, rate or extent of the regulated release of serotonin. + GOC:ef + + + + + regulation of serotonin release + GOC:tb - + - + - + - - + + - + + + - - + + - steroid hormone secreting cell + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. + down regulation of serotonin secretion + down-regulation of serotonin secretion + downregulation of serotonin secretion + inhibition of serotonin secretion + biological_process + positive regulation of serotonin release + GO:0014063 + negative regulation of serotonin secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. + GOC:ef + + + + + positive regulation of serotonin release + GOC:tb + - + - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + + - - + + - - - - - - - The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated. - - BTO:0000575 - CALOHA:TS-0454 - FMA:14515 - - Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive. - hepatocyte + Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin. + up regulation of serotonin secretion + up-regulation of serotonin secretion + upregulation of serotonin secretion + activation of serotonin secretion + stimulation of serotonin secretion + biological_process + positive regulation of serotonin release + GO:0014064 + positive regulation of serotonin secretion - + - The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated. - GOC:tfm - ISBN:0412046911 - MESH:D022781 - PMID:19717280 - http://en.wikipedia.org/wiki/Hepatocyte + Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin. + GOC:ef + + + + + positive regulation of serotonin release + GOC:tb - + - - - A cell whose primary function is to shorten. - contractile cell + + + A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. + biological_process + GO:0014821 + phasic smooth muscle contraction - + - A cell whose primary function is to shorten. - FB:ma + A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. + GOC:mtg_muscle - + - - - - - - - - - - - A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. - BTO:0000888 - BTO:0000902 - CALOHA:TS-2032 - FBbt:00005074 - FMA:67328 - WBbt:0003675 - muscle fiber - myocyte - muscle cell - https://www.swissbiopics.org/api/image/Muscle_cells.svg + + + + + The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GO:0015831 + enzyme transport + biological_process + GO:0015031 + + + + protein transport - + - A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. - MESH:D032342 + The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai - + - - - - - - - - - - - - - - - - - - - - - A somatic cell located in skeletal muscle. - - BTO:0004392 - CALOHA:TS-2158 - FMA:9727 - skeletal muscle cell - - - cell of skeletal muscle + + + The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. + cellular_component + GO:0015629 + actin cytoskeleton - + - A somatic cell located in skeletal muscle. - GOC:tfm + The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. + GOC:jl + ISBN:0395825172 + ISBN:0815316194 - + - - - - - - - - - - A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast). - - non-striated muscle cell - BTO:0004576 - CALOHA:TS-2159 - FMA:14072 - SMCs - myocytes, smooth muscle - smooth muscle fiber - - - smooth muscle cell + + + + The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. + biological_process + GO:0015695 + organic cation transport - + - A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast). - MESH:D032389 - PMID:9315361 - http://en.wikipedia.org/wiki/Smooth_muscle_cell - - - - - SMCs - PMID:9315361 - - - - - myocytes, smooth muscle - MESH:D032389 + The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. + GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A cell that is capable of detection of a stimulus involved in sensory perception. - MESH:D011984 - receptor cell - sensory receptor cell - - - - - + - - - - - - - - - - - - - - - - - - - - A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood. - chemoreceptor cell + + + + The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. + biological_process + GO:0015711 + organic anion transport - + - A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood. - MESH:D002628 + The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. + GOC:ai + GOC:krc - + - - - - - - - - - - - - - - - - - - - - A cell specialized to detect and transduce light. - BTO:0001060 - CALOHA:TS-0868 - FMA:86740 - photoreceptor cell - https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg + + + The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0015718 + monocarboxylic acid transport - - - - true - - - + - A cell specialized to detect and transduce light. - MESH:D010786 + The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:krc - + - - - A cell whose function is determined by the generation or the reception of an electric signal. - electrically active cell + + + + + + The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + bile acid transport + bile salt transport + biological_process + GO:0015721 + bile acid and bile salt transport - + - A cell whose function is determined by the generation or the reception of an electric signal. - FB:ma + The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:dph + GOC:krc + PMID:12663868 + PMID:14699511 - + - - - A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism. - boundary cell - lining cell + + + + The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0015833 + + peptide transport - + - A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism. - JB:jb + The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai - + - - - - - - - - - - A cell located in the synovial joint. - CALOHA:TS-0995 - synoviocyte - synovial cell + + + + The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + amine/polyamine transport + GO:0015837 + + amine transport - - - - true + + + The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + ISBN:0198506732 - + - - - A cell whose primary function is to prevent the transport of stuff across compartments. - barrier cell + + + + The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GO:0015873 + biological_process + GO:0015844 + monoamine transport - + - A cell whose primary function is to prevent the transport of stuff across compartments. - JB:jb + The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah - + - - - - - - - - - - - - - - - - - - - - A cell that moves by its own activities. - motile cell + + + The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0015849 + + organic acid transport - + - A cell that moves by its own activities. - FB:ma + The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + ISBN:0198506732 - + - - - - - - - - - A cell of the outer of the three germ layers of the embryo. - FMA:72549 - ectoderm cell - ectodermal cell + + + The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. + organic alcohol transport + biological_process + GO:0015850 + organic hydroxy compound transport - + - A cell of the outer of the three germ layers of the embryo. - MESH:D004475 + The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. + GOC:ai - + - - - - - - - - - A cell of the middle germ layer of the embryo. - FMA:72554 - mesoblast - mesoderm cell - mesodermal cell + + + + The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. + levarterenol transport + noradrenaline transport + biological_process + GO:0015874 + norepinephrine transport - + - A cell of the middle germ layer of the embryo. - MESH:D008648 + The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. + GOC:ai + ISBN:0198506732 - + - - - - - - - - - A cell of the inner of the three germ layers of the embryo. - FMA:72555 - endoderm cell - endodermal cell + + + The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. + chemoorganotrophy + biological_process + GO:0015980 + energy derivation by oxidation of organic compounds - + - A cell of the inner of the three germ layers of the embryo. - MESH:D004707 + The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. + GOC:mah - + - - - - - - - - - - - - - - - - - - - - - A cell that lacks a nucleus. - FMA:68647 - non-nucleated cell - anucleate cell + + + A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. + 2014-03-06T11:37:54Z + GO:0098589 + GO:0098805 + Wikipedia:Biological_membrane + membrane region + region of membrane + whole membrane + cellular_component + GO:0016020 + + + + + + + + membrane - + - A cell that lacks a nucleus. - FB:ma + A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. + GOC:dos + GOC:mah + ISBN:0815316194 - + - - - - - - - - - - - - - - - - - - - - A cell with a single nucleus. - single nucleate cell + + + + The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + GO:0006093 + anabolic carbohydrate metabolic process + anabolic carbohydrate metabolism + carbohydrate anabolism + carbohydrate biosynthesis + carbohydrate formation + carbohydrate synthesis + biological_process + GO:0016051 + carbohydrate biosynthetic process - + - A cell with a single nucleus. - FB:ma - GOC:tfm + The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - binucleate cell - - - - - + - - - - - - - - - - - - - - - - - - - - A cell with more than one nucleus. - AEO:0000203 - WBbt:0008074 - syncitium - syncytial cell - syncytium - multinucleate cell + + + + The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + jl + 2012-10-23T16:34:39Z + GO:0006095 + GO:0044276 + GO:0044724 + carbohydrate breakdown + carbohydrate catabolism + carbohydrate degradation + catabolic carbohydrate metabolic process + catabolic carbohydrate metabolism + multicellular organismal carbohydrate catabolic process + biological_process + single-organism carbohydrate catabolic process + GO:0016052 + carbohydrate catabolic process - + - A cell with more than one nucleus. - FB:ma + The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + ISBN:0198506732 - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen. - - BTO:0000424 - CALOHA:TS-0290 - FMA:81100 - RBC - red blood cell - - - erythrocyte + + + + + + The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. + organic acid anabolism + organic acid biosynthesis + organic acid formation + organic acid synthesis + biological_process + GO:0016053 + organic acid biosynthetic process - - - - true - - - + - A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen. - GOC:tfm - MESH:D004912 + The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. + ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - MESH:D005057 - eukaryotic cell - - - - - - - - - - - - - - - - - - - - - - - - - - Eumycetozoan cell - - - - - - - - - - - - - - - - - - - - - - - - - - - - - eye photoreceptor cell - - - - - + - - - A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism. - structural cell + + + kinase activity - - - - A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism. - TAIR:sr - - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A mature sexual reproductive cell having a single set of unpaired chromosomes. - CALOHA:TS-0395 - FBbt:00005412 - FMA:18649 - haploid nucleated cell - haploid germ cell - gamete + + + + The process in which the anatomical structures of embryonic epithelia are generated and organized. + biological_process + GO:0016331 + morphogenesis of embryonic epithelium - - - - true - - - + - A mature sexual reproductive cell having a single set of unpaired chromosomes. - GOC:tfm - ISBN:0721662544 + The process in which the anatomical structures of embryonic epithelia are generated and organized. + GOC:jl - - - - - lens cell - - crystallin accumulating cell - - - - - + - - - Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid. - BTO:0003687 - FMA:62511 - serous cell - serous secreting cell + + + The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. + Wikipedia:Cell_migration + biological_process + GO:0016477 + cell migration - + - Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid. - GOC:tfm - ISBN:0517223651 - ISBN:0721662544 + The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. + GOC:cjm + GOC:dph + GOC:ems + GOC:pf + Wikipedia:Cell_migration - + - + - + - - + + - + + - - + + - BTO:0003689 - mucous cell - mucus secreting cell - - - - - - - - - A cell that is specialised to accumulate a particular substance(s). - - stuff accumulating cell + Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. + down regulation of angiogenesis + down-regulation of angiogenesis + downregulation of angiogenesis + inhibition of angiogenesis + biological_process + GO:0016525 + negative regulation of angiogenesis - + - A cell that is specialised to accumulate a particular substance(s). - FB:ma + Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. + GOC:go_curators - - - - - extracellular matrix secreting cell - - - - - + - + - + - - + + - - - - - - - - oxygen accumulating cell - - - - - - - - - - - + + - - + + - A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. - FMA:86667 - migratory neural crest cell + sarcoplasm - - - - A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. - doi:10.1016/j.stem.2015.02.017 - - + - - - A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors. - mesenchyme condensation cell + + + transferase activity - - - - A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors. - GOC:tfm - PMID:5025404 - - + - - - - - - - - - - - - - - - - - - - - - - - - - - - A cell of the sclera of the eye. - - scleral cell + + + transferase activity, transferring phosphorus-containing groups - - - - A cell of the sclera of the eye. - GOC:add - - + - + - + - + - - - - - - - - - - - - - - - A structural cell that is part of optic choroid. - - choroidal cell of the eye - - - - - A structural cell that is part of optic choroid. - GOC:add - - - - - - - - + - + - + + - + - - extraembryonic cell - - - - - - - - - + - A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface. - FMA:83028 - trophoblastic cell - trophoblast cell - - - - - - true - - - - - A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface. - GOC:tfm - MESH:D014327 - - - - - - - - - A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation. - epiblast cell - - - - - A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation. - GOC:tfm - ISBN:0618947256 - - - - - - - - - An undifferentiated cell produced by early cleavages of the fertilized egg (zygote). - BTO:0001473 - FMA:72551 - blastomere - blastoderm cell - - - - - An undifferentiated cell produced by early cleavages of the fertilized egg (zygote). - MESH:D001756 - - - - - - - - - - - - - - - - - - - - - - - - - - - A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell. - FMA:86767 - Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo. - multi-potent skeletal muscle stem cell - - - - - - true - - - - - A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell. - PMID:18282570 - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. - sphincter associated smooth muscle cell - - - - - - true - - - - - A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. - GOC:cjm - - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell associated with the vasculature. - - VSMC - vascular smooth muscle cell - - vascular associated smooth muscle cell - - - - - - true - - - - - A smooth muscle cell associated with the vasculature. - GOC:dsd - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - An epithelial cell of the integument (the outer layer of an organism). - BTO:0001470 - CALOHA:TS-0283 - FMA:62411 - MESH:D000078404 - cell of epidermis - epithelial cell of skin - epidermal cell - - - - - An epithelial cell of the integument (the outer layer of an organism). - Flybase:dsj - MA:ma - - - - - cell of epidermis - FMA:62411 - - - - - epithelial cell of skin - FMA:62411 - - - - - - - - - - - - - - - - - - - - - - - - - - - - Diploid cell produced by the fusion of sperm cell nucleus and egg cell. - zygote - BTO:0000854 - EHDAA2:0004546 - FMA:72395 - animal zygote - - - - - Diploid cell produced by the fusion of sperm cell nucleus and egg cell. - ISBN:0471245208 - - - - - - - - - A cell whose function is determined by its response to an electric signal. - electrically responsive cell - - - - - A cell whose function is determined by its response to an electric signal. - FB:ma - - - - - - - - - - - - - - - - - - - - - - - - - - ganglion interneuron - - - - - - true - - - - - - - - - - - - - - - - - - - - - - - - - - - An interneuron that has its cell body in a central nervous system. - - - Interneurons are commonly described as being only found in the central nervous system. However, in CL we define 'interneuron' more broadly as any neuron that is neither a motor neuron nor a sensory neuron, regardless of its location, so we need this term to refer strictly to interneurons of the central nervous system. - CNS interneuron - - - - - An interneuron that has its cell body in a central nervous system. - doi:10.1016/B978-0-12-817424-1.00001-X - - - - - - - - - A cell that initiates an electrical signal and passes that signal to another cell. - electrically signaling cell - - - - - A cell that initiates an electrical signal and passes that signal to another cell. - FB:ma - - - - - - - - - - - - - - - - - - - - - - - - - - A cell that contains more than two haploid sets of chromosomes. - polyploid cell - - - - - A cell that contains more than two haploid sets of chromosomes. - FB:ma - PMID:32646579 - https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.04%3A_Polyploidy - - - - - - - - - - - - - - - - - - - - - - - - - - A cell whose nucleus contains a single haploid genome. - - - haploid cell - - - - - A cell whose nucleus contains a single haploid genome. - FB:ma - GOC:tfm - - - - - - - - - endopolyploid cell - - - - - - - - - carbohydrate secreting cell - - - - - - - - - biogenic amine secreting cell - - - - - - - - - - - - - - - - - - - - - - - - - - A cell type that secretes 5-Hydroxytryptamine (serotonin). - 5-HT secreting cell - 5-Hydroxytryptamine secreting cell - serotonin secreting cell - - - - - A cell type that secretes 5-Hydroxytryptamine (serotonin). - GOC:tfm - PMID:19630576 - - - - - - - - - - - - - - - - - - - - - - - - - - A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme. - noradrenaline secreting cell - norepinephrin secreting cell - norepinephrine secreting cell - noradrenergic cell - - - - - A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme. - GOC:tfm - ISBN:068340007X - - - - - - - - - - - - - - - - - - - - - - - - - - A photoreceptor cell that detects visible light. - visible light photoreceptor cell - - - - - A photoreceptor cell that detects visible light. - GOC:tfm - - - - - - - - - - - - - - - A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere. - - BTO:0002064 - FMA:83624 - - - stromal cell - - - - - A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere. - GOC:tfm - MESH:D017154 - - - - - - - - - - - - - - - - A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin. - FMA:62935 - D cell - type D enteroendocrine cell - - - - - A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin. - MESH:D019864 - - - - - - - - - An endorphine cell that secretes enkephalin. - enkephalin secreting cell - - - - - An endorphine cell that secretes enkephalin. - GO:tfm - - - - - - - - - A peptide hormone secreting cell that secretes endorphin. - endorphin secreting cell - - - - - A peptide hormone secreting cell that secretes endorphin. - GO:tfm - - - - - - - - - - - - - - - - - - An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli. - BTO:0004108 - FMA:67609 - G cell - type G enteroendocrine cell - - - - - An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli. - GOC:tfm - ISBN:0517223651 - MESH:D019863 - - - - - - - - - A peptide hormone secreting cell that secretes gastrin. - - - gastrin secreting cell - - - - - A peptide hormone secreting cell that secretes gastrin. - GO:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A precursor cell destined to differentiate into cardiac muscle cell. - FMA:84797 - cardiac muscle progenitor cell - cardiomyocyte progenitor cell - cardiac muscle myoblast - - - - - - true - - - - - A precursor cell destined to differentiate into cardiac muscle cell. - GOC:tfm - MESH:D032386 - - - - - - - - - - - - - - - - - - - - - - - - - - A precursor cell destined to differentiate into smooth muscle myocytes. - FMA:84798 - myoblast, smooth muscle - satellite cell - smooth muscle myoblast - - - - - A precursor cell destined to differentiate into smooth muscle myocytes. - GOC:tfm - MESH:D032390 - - - - - myoblast, smooth muscle - MESH:D032390 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A myoblast that differentiates into skeletal muscle fibers. - FMA:84799 - skeletal myoblast - skeletal muscle myoblast - - - - - A myoblast that differentiates into skeletal muscle fibers. - SANBI:mhl - - - - - - - - - - - - - - - - - - - - - - - - - - fungal cell - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy. - - FMA:83043 - syncytial trophoblast cell - syncytiotrophoblastic cell - plasmidotrophoblast cell - syntrophoblast cell - - syncytiotrophoblast cell - https://github.com/obophenotype/cell-ontology/issues/2100 - - - - - A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy. - GOC:tfm - ISBN:0323052908 - - - - - syncytial trophoblast cell - PMID:11787150 - - - - - syncytiotrophoblastic cell - PMID:21733368 - - - - - - - - - A neuron which conveys sensory information centrally from the periphery. - - FMA:87653 - input neuron - - afferent neuron - - - - - A neuron which conveys sensory information centrally from the periphery. - GOC:tfm - MESH:D009475 - - - - - - - - - A neuron which sends impulses peripherally to activate muscles or secretory cells. - output neuron - efferent neuron - - - - - A neuron which sends impulses peripherally to activate muscles or secretory cells. - MESH:D009476 - - - - - - - - - - - - - - - - - The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. - - BTO:0000938 - CALOHA:TS-0683 - FBbt:00005106 - FMA:54527 - VHOG:0001483 - WBbt:0003679 - nerve cell - - - These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. - neuron - https://www.swissbiopics.org/api/image/Neuron_cells.svg - - - - - The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. - MESH:D009474 - http://en.wikipedia.org/wiki/Neuron - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers. - FMA:83518 - rubriblast - pronormoblast - - proerythroblast - - - - - - true - - - - - An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers. - ISBN:0721601464 - PMID:1638021 - - - - - rubriblast - ISBN:0721601464 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers. - FMA:83505 - basophilic normoblast - early erythroblast - early normoblast - prorubricyte - basophilic erythroblast - - - - - - true - - - - - A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers. - GOC:tfm - ISBN:0721601464 - - - - - basophilic normoblast - ISBN:0721601464 - - - - - early erythroblast - ISBN:0721601464 - - - - - early normoblast - ISBN:0721601464 - - - - - prorubricyte - ISBN:0721601464 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers. - FMA:83506 - intermediate erythroblast - intermediate normoblast - polychromatic erythroblast - polychromatic normoblast - polychromatophilic normoblast - rubricyte - polychromatophilic erythroblast - - - - - - true - - - - - A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers. - ISBN:0721601464 - - - - - intermediate erythroblast - ISBN:0721601464 - - - - - intermediate normoblast - ISBN:0721601464 - - - - - polychromatic erythroblast - ISBN:0721601464 - - - - - polychromatic normoblast - ISBN:0721601464 - - - - - polychromatophilic normoblast - ISBN:0721601464 - - - - - rubricyte - ISBN:0721601464 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated. - FMA:84646 - acidophilic erythroblast - eosinophilic erythroblast - late erythoblast - orthochromatic normoblast - pyknotic eto enrythroblast - orthochromatic erythroblast - - - - - - true - - - - - The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated. - ISBN:0721601464 - - - - - acidophilic erythroblast - ISBN:0721601464 - - - - - eosinophilic erythroblast - ISBN:0721601464 - - - - - orthochromatic normoblast - ISBN:0721601464 - - - - - pyknotic eto enrythroblast - ISBN:0721601464 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative). - - BTO:0001164 - CALOHA:TS-0610 - FMA:84235 - MESH:D055016 - CFU-Meg - Meg-CFC - MkP - colony-forming unit-megakaryocyte - megacaryoblast - megacaryocyte progenitor cell - megakaryoblast - megakaryocytic progenitor cell - promegacaryocyte - promegakaryocyte - - Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative. - megakaryocyte progenitor cell - - - - - - true - - - - - The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative). - GOC:dsd - GOC:tfm - ISBN:0721601464 - - - - - CFU-Meg - PMID:11722431 - PMID:12482498 - - - - - Meg-CFC - PMCID:PMC1794060 - - - - - MkP - PMID:21116988 - - - - - megakaryocytic progenitor cell - PMID:12482498 - - - - - - - - - - - - - - - - - - - - - - A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release. - - BTO:0000843 - CALOHA:TS-0611 - FMA:83555 - megacaryocyte - megalocaryocyte - megalokaryocyte - - - Megakaryocytes are reportedly CD181-positive and CD182-positive. - megakaryocyte - - - - - - true - - - - - A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release. - ISBN:0721601464 - MESH:D008533 - PMID:31043076 - http://en.wikipedia.org/wiki/Megakaryocyte - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds. - BTO:0001173 - CALOHA:TS-0864 - MESH:D012156 - - reticulocyte - - - - - - true - - - - - An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds. - GOC:add - GOC:tfm - PMID:15946868 - PMID:2037622 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An erythrocyte having a nucleus. - RBC - red blood cell - nucleate erythrocyte - - - - - - true - - - - - An erythrocyte having a nucleus. - GOC:add - GOc:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A mesenchymal stem cell capable of developing into blood vessel endothelium. - angioblast - chondroplast - These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive. - angioblastic mesenchymal cell - - - - - - true - - - - - A mesenchymal stem cell capable of developing into blood vessel endothelium. - GOC:dsd - GOC:tfm - PMID:12768659 - - - - - - - - - - - - - - - - - - - - - - - - - - - A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field. - cardiac mesenchymal cell - - - - - A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field. - PMID:18816864 - - - - - - - - - - - - - - - One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision. - - BTO:0001036 - CALOHA:TS-0866 - FMA:67748 - cone - - retinal cone cell - - - - - One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision. - MESH:D017949 - - - - - cone - doi:10.1038/s41598-020-66092-9 - - - - - - - - - - - - - - - - - - - - - - - - - - - - An epithelial cell of the cornea. - - BTO:0004298 - CALOHA:TS-0173 - FMA:70551 - epithelial cell of cornea - - - corneal epithelial cell - - - - - An epithelial cell of the cornea. - GOC:tfm - - - - - epithelial cell of cornea - FMA:70551 - - - - - - - - - - - - - - - The reproductive cell in multicellular organisms. - BTO:0000535 - NCIT:C12597 - VHOG:0001534 - WBbt:0006796 - germ cell - - - - - - true - - - - - The reproductive cell in multicellular organisms. - MESH:D005854 - - - - - - - - - - - - - - - - - - - - - - - - - - A steroid hormone secreting cell that secretes androgen. - androgen secreting cell - - - - - A steroid hormone secreting cell that secretes androgen. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An erythrocyte lacking a nucleus. - red blood cell - RBC - enucleate erythrocyte - - - - - - true - - - - - An erythrocyte lacking a nucleus. - GOC:add - GOC:tfm - - - - - RBC - - - - - - - - - - - - - - - - One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision. - - BTO:0001024 - CALOHA:TS-0870 - FMA:67747 - rod - - retinal rod cell - - - - - One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision. - MESH:D017948 - - - - - rod - doi:10.1038/s41598-020-66092-9 - - - - - - - - - - - - - - - - A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus). - FMA:83625 - MESH:D061354 - acinic cell - acinous cell - acinar cell - - - - - A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus). - GOC:tfm - http://www.copewithcytokines.de - - - - - - - - - A cell whose primary function is to support other cell types. - BTO:0002315 - supportive cell - supporting cell - - - - - A cell whose primary function is to support other cell types. - FB:ma - GOC:tfm - - - - - - - - - An extracellular matrix secreting cell that secretes collagen. - collagen secreting cell - - - - - An extracellular matrix secreting cell that secretes collagen. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells. - FMA:70567 - gonocyte - primitive germ cell - primordial germ cell - - - - - - true - - - - - - true - - - - - A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells. - GOC:tfm - PMID:1381289 - - - - - - - - - - A mature sexual reproductive cell of the female germline. - female gamete - - - - - - true - - - - - A mature sexual reproductive cell of the female germline. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A non-terminally differentiated cell that is capable of developing into a muscle cell. - muscle precursor cell - - - - - A non-terminally differentiated cell that is capable of developing into a muscle cell. - GOC:add - - - - - - - - - - A cell that stores and secretes pancreatic polypeptide hormone. - FMA:62938 - FMA:83409 - type F enteroendocrine cell - PP cell - - - - - A cell that stores and secretes pancreatic polypeptide hormone. - GOC:tfm - JB:jb - PMID:15153415 - - - - - - - - - - - - - - - - - - - - - - - - - - - Epithelial cells derived from neural plate and neural crest. - neuroepithelial cell - BTO:0004301 - FMA:70557 - The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). - neurecto-epithelial cell - - - - - Epithelial cells derived from neural plate and neural crest. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - A stem cell that can give rise to cell types of the body other than those of the germ-line. - CALOHA:TS-2086 - FMA:63368 - MESH:D053687 - somatic stem cell - - - - - A stem cell that can give rise to cell types of the body other than those of the germ-line. - GO:0048103 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Muscle cell which has as its direct parts myofilaments organized into sarcomeres. - BTO:0002916 - CALOHA:TS-2157 - FMA:86936 - striated muscle cell - - - - - Muscle cell which has as its direct parts myofilaments organized into sarcomeres. - GOC:tfm - ISBN:0721662544 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. - - BTO:0000751 - CALOHA:TS-0549 - FMA:62852 - MESH:D007962 - NCIT:C12529 - leucocyte - white blood cell - immune cell - - leukocyte - - - - - - true - - - - - An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. - GOC:add - GOC:tfm - ISBN:978-0-323-05290-0 - - - - - - - - - - - - - - - The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve. - - BTO:0001800 - FMA:67765 - MESH:D012165 - gangliocyte - ganglion cell of retina - RGC - RGCs - - - retinal ganglion cell - - - - - The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve. - GOC:dph - - - - - RGC - doi:10.1038/s41598-020-66092-9 - - - - - - RGCs - doi:10.1038/s41598-020-66092-9 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei. - - FMA:83808 - cardiocyte - BTO:0001539 - CALOHA:TS-0115 - FMA:14067 - MESH:D032383 - cardiac muscle fiber - cardiac myocyte - cardiomyocyte - heart muscle cell - - - This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction. - cardiac muscle cell - - - - - Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei. - GOC:mtg_cardiacconduct_nov11 - GOC:tfm - ISBN:0323052908 - PMID:22426062 - PMID:4711263 - - - - - cardiac muscle fiber - GO:0048739 - - - - - - - - - - - - - - - - - - - - - - - - - - A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. - BTO:0001441 - CALOHA:TS-0647 - MESH:D022423 - myeloid cell - - - - - - true - - - - - A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. - GOC:add - - - - - - - - - A immature or mature cell in the lineage leading to and including erythrocytes. - - CALOHA:TS-0290 - FMA:62845 - FMA:83516 - erythropoietic cell - - Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes. - erythroid lineage cell - - - - - A immature or mature cell in the lineage leading to and including erythrocytes. - GOC:add - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers. - BTO:0001571 - CALOHA:TS-0289 - FMA:83504 - MESH:D004900 - normoblast - - erythroblast - - - - - - true - - - - - A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers. - GOC:add - ISBN:0721601464 - PMID:18174176 - - - - - - - - - - - - - - - - - - - - - - - - - - - A cell of the monocyte, granulocyte, or mast cell lineage. - myeloid leukocyte - - - - - - true - - - - - A cell of the monocyte, granulocyte, or mast cell lineage. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans. - - BTO:0000725 - CALOHA:TS-0448 - MPP - hemopoietic progenitor cell - - - Markers differ between mouse and human. - hematopoietic multipotent progenitor cell - - - - - - true - - - - - A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans. - GOC:add - GOC:tfm - PMID:19022770 - - - - - - - - - - - - - - - - - - - - - - - - - - - A progenitor cell restricted to the myeloid lineage. - myeloid progenitor cell - BTO:0004730 - CALOHA:TS-2099 - FMA:70339 - Note that this is a class of cell types, not an identified single cell type. - myeloid lineage restricted progenitor cell - - - - - - true - - - - - A progenitor cell restricted to the myeloid lineage. - GOC:add - GOC:tfm - PMID:19022770 - - - - - - - - - - - - - - - - - - - - - - - - - - - A leukocyte with a single non-segmented nucleus in the mature form. - BTO:0000878 - CALOHA:TS-0768 - FMA:86713 - mononuclear leukocyte - peripheral blood mononuclear cell - - mononuclear cell - - - - - - true - - - - - A leukocyte with a single non-segmented nucleus in the mature form. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - A neuron that releases serotonin as a neurotransmitter. - FBbt:00005133 - MESH:D059326 - WBbt:0006837 - 5-HT neuron - 5-hydroxytryptamine neuron - serotinergic neuron - serotonergic neuron - - - - - A neuron that releases serotonin as a neurotransmitter. - SANBI:mhl - - - - - - - - - A cell of a hematopoietic lineage. - BTO:0000574 - CALOHA:TS-2017 - FMA:70366 - FMA:83598 - haematopoietic cell - haemopoietic cell - hemopoietic cell - hematopoietic cell - - - - - A cell of a hematopoietic lineage. - GOC:add - GO_REF:0000031 - - - - - - - - - - - - - - - - - - - - - - - - - - A connective tissue cell found in bone. - - - 2011-11-16T04:28:16Z - - - bone cell - - - - - A connective tissue cell found in bone. - GOC:add - GO_REF:0000034 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers. - - 2010-01-06T03:43:27Z - hematopoietic oligopotent progenitor cell, lineage-negative - - - - - A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers. - GOC:tfm - PMID:19022770 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative). - BTO:0004911 - BFU-E - CFU-E - blast forming unit erythroid - burst forming unit erythroid - colony forming unit erythroid - erythroid stem cell - erythroid progenitor cell, mammalian - - - - - A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative). - GOC:add - ISBN:0721601464 - - - - - BFU-E - - - - - - CFU-E - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells. - - 2010-01-06T03:43:20Z - - hematopoietic lineage restricted progenitor cell - - - - - - true - - - - - A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells. - GOC:tfm - PMID:19022770 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. - - 2010-01-06T03:43:27Z - - This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). - hematopoietic oligopotent progenitor cell - - - - - - true - - - - - A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. - GOC:tfm - PMID:19022770 - https://orcid.org/0000-0001-5208-3432 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules. - - - 2010-06-24T03:16:29Z - BTO:0000028 - CALOHA:TS-0737 - FMA:63032 - acinar cell of pancreas - - pancreatic acinar cell - - - - - - true - - - - - - true - - - - - A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules. - GOC:tfm - ISBN:0517223651 - PMID:20395539 - http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells - - - - - - - - - - - - - - - - - - - - - - - - - - - An enteroendocrine cell that produces glucagon. - - 2010-09-10T10:48:54Z - FMA:62939 - type A enteroendocrine cell - - - - - An enteroendocrine cell that produces glucagon. - GOC:tfm - ISBN:0412046911 - - - - - - - - - Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter. - - - 2010-06-28T08:36:15Z - BTO:0001032 - FMA:14146 - Purkinje cell fiber - Purkinje muscle cell - myocytus conducens cardiacus - - Purkinje myocyte - - - - - Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter. - FMA:0412046911 - GOC:tfm - PMID:19939742 - - - - - - - - - A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery. - - 2010-06-29T11:41:37Z - pacemaker cell - BTO:0004190 - FMA:67101 - P cell - cardiac pacemaker cell - myocytus nodalis - nodal myocyte - - - - - A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery. - FMA:67101 - GOC:tfm - - - - - cardiac pacemaker cell - GOC:pr - - - - - - - - - Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes. - - 2010-06-29T02:39:32Z - FMA:67142 - transitional myocyte - - - - - Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes. - FMA:67142 - GOC:tfm - - - - - - - - - - The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides). - - 2010-06-29T11:50:47Z - FMA:67111 - myocardial endocrine cell - - - - - The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides). - FMA:67111 - GOC:tfm - - - - - - - - - - - - - - - - An epithelial cell derived from endoderm. - - 2010-06-29T03:38:14Z - FMA:69075 - endo-epithelial cell - - - - - An epithelial cell derived from endoderm. - FMA:69075 - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - An epithelial cell derived from ectoderm. - - 2010-06-29T03:38:22Z - FMA:69074 - ecto-epithelial cell - - - - - An epithelial cell derived from ectoderm. - FMA:69074 - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - Epithelial cell derived from mesoderm or mesenchyme. - - 2010-06-29T03:49:14Z - FMA:69076 - epithelial mesenchymal cell - meso-epithelial cell - - - - - Epithelial cell derived from mesoderm or mesenchyme. - FMA:69076 - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH. - - - 2010-06-30T08:49:43Z - FMA:63099 - - pancreatic ductal cell - - - - - - true - - - - - Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH. - FMA:63099 - GOC:tfm - PMID:14740223 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types. - - - 2010-06-30T08:49:52Z - FMA:62455 - centroacinar cell of Langerhans - pancreatic centroacinar cell - - pancreatic centro-acinar cell - - - - - - true - - - - - A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types. - GOC:tfm - PMID:12142741 - PMID:20018761 - PMID:8185160 - - - - - - - - - A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart. - - 2010-07-21T01:33:38Z - FMA:67968 - specialized cardiac myocyte - - - - - A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart. - FMA:67968 - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - A leukocyte that lacks granules. - - 2010-07-22T11:30:33Z - FMA:62855 - agranular leukocyte - - nongranular leukocyte - - - - - - true - - - - - A leukocyte that lacks granules. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise. - - - 2010-07-22T03:26:00Z - BTO:0003914 - FMA:86573 - ICC - intestinal pacemaker cell - - Some argue this cell type is of mesenchymal origin. - interstitial cell of Cajal - - - - - - true - - - - - This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise. - GOC:tfm - PMID:16460275 - PMID:19520112 - - - - - intestinal pacemaker cell - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - - A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells. - - 2010-07-22T04:48:15Z - BTO:0004850 - FMA:83621 - MESH:D001854 - MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. - bone marrow cell - - - - - - true - - - - - A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells. - GOC:tfm - ISBN:0618947256 - - - - - - - - - - A cell in the hilum of the ovary that produces androgens. - - - 2010-08-23T11:18:18Z - FMA:18710 - hilar cell of ovary - - hilus cell of ovary - - - - - A cell in the hilum of the ovary that produces androgens. - GOC:tfm - ISBN:068340007X - - - - - - - - - - - - - - - - - - - - - - - - - - A stomal cell of the ovary - - 2010-08-23T12:10:31Z - FMA:72299 - ovarian stromal cell - stromal cell of ovary - - - - - A stomal cell of the ovary - GOC:tfm - - - - - ovarian stromal cell - GOC:cjm - - - - - - - - - An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels. - - 2010-08-24T02:06:40Z - BTO:0001854 - CALOHA:TS-1106 - FMA:67755 - vascular endothelial cell - cubodial endothelial cell of vascular tree - These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive. - endothelial cell of vascular tree - - - - - An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels. - GOC:dsd - GOC:tfm - PMID:12768659 - - - - - - - - - - - - - - - - - - - - - - - - - - - An endothelial cell found in capillaries. - - - 2010-08-24T10:15:00Z - BTO:0004956 - CALOHA:TS-0112 - FMA:67756 - - capillary endothelial cell - - - - - - true - - - - - An endothelial cell found in capillaries. - GOC:tfm - - - - - - - - - Epithelial cells derived from general body ectoderm and ectoderm placodes. - - 2010-08-26T08:31:08Z - FMA:70556 - general ecto-epithelial cell - - - - - Epithelial cells derived from general body ectoderm and ectoderm placodes. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - An epithelial cell found in the lining of the stomach. - - 2010-08-25T03:22:08Z - FMA:62948 - epithelial cell of stomach - - - - - - true - - - - - An epithelial cell found in the lining of the stomach. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A mucous cell in the epithelium of the stomach. - - 2010-08-25T03:38:51Z - FMA:63464 - mucous cell of stomach - - - - - - true - - - - - A mucous cell in the epithelium of the stomach. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit. - - 2010-08-25T03:57:08Z - FMA:62953 - stem cell of gastric gland - - - - - - true - - - - - A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit. - GOC:tfm - ISBN:0517223651 - - - - - - - - - - - - - - - - - - - - - - - - - - - A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes). - - 2010-08-30T02:00:42Z - FMA:86577 - HpSC - hepatic stem cell - https://github.com/obophenotype/cell-ontology/issues/800 - - - - - - true - - - - - A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes). - GOC:tfm - PMID:26798363 - - - - - HpSC - PMID:18442648 - - - - - - - - - - - - - - - - - - A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye. - - 2010-09-07T10:38:03Z - FMA:70950 - - vertebrate lens cell - - - - - A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye. - GOC:tfm - ISBN:0721662544 - - - - - - - - - - - - - - - - - - - - - - - - - - - A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth. - - - 2010-09-07T10:45:47Z - FMA:67559 - - lens epithelial cell - - - - - - true - - - - - A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth. - GOC:tfm - ISBN:0721662544 - http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium - - - - - - - - - - - - - - - - - - - - - - - - - - - A fibroblast in the bone marrow. - - 2010-09-07T02:25:18Z - FMA:84377 - marrow fibroblast - - - - - A fibroblast in the bone marrow. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - A cell containing at least one nucleus. - - 2010-09-07T03:32:33Z - FMA:67513 - nucleate cell - - - - - A cell containing at least one nucleus. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells. - - 2010-09-08T08:53:42Z - FMA:70611 - smooth muscle fiber of sphincter of pupil - smooth muscle fibre of sphincter of pupil - smooth muscle cell of sphincter of pupil - - - - - - true - - - - - A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells. - GOC:tfm - ISBN:0721662544 - ISBN:0721694128 - - - - - - - - - - - - - - - - - - - - - - - - - - - - A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells). - - 2010-09-07T03:57:09Z - BTO:0002669 - FMA:86711 - MESH:D000072916 - PBSC - peripheral blood stem cell - - - - - - true - - - - - A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells). - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus. - - 2010-09-08T09:26:53Z - epithelial cell of alimentary canal - - - - - An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus. - GOC:tfm - ISBN:0721662544 - - - - - - - - - - - - - - - - - - - - - - - - - - An epithelial cell of the esophagus. - - 2010-09-08T09:28:20Z - FMA:63071 - epithelial cell of esophagus - - - - - - true - - - - - An epithelial cell of the esophagus. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - An epithelial cell of the large intestine. - - 2010-09-08T09:28:22Z - BTO:0004297 - FMA:256157 - epithelial cell of colon - epithelial cell of large intestine - - - - - - true - - - - - An epithelial cell of the large intestine. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - An epithelial cell of the small intestine. - - 2010-09-08T09:41:46Z - FMA:256159 - epithelial cell of small intestine - - - - - - true - - - - - An epithelial cell of the small intestine. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver. - - - 2010-09-14T10:57:26Z - FMA:63134 - - endothelial cell of sinusoid - - - - - An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver. - GOC:tfm - ISBN:0618947256 - - - - - - - - - - - - - - - - - - - - - - - - - - - A type of enteroendocrine cell found in the stomach that secretes glucagon. - - 2010-09-10T10:54:42Z - FMA:83411 - type A cell of stomach - - - - - A type of enteroendocrine cell found in the stomach that secretes glucagon. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A D cell located in the colon. - - 2010-09-10T11:37:35Z - FMA:268744 - colon D-cell - colonic delta cell - delta cell of colon - type D cell of colon - - - - - A D cell located in the colon. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A type D cell of the small intestine. - - 2010-09-10T01:34:22Z - FMA:268736 - delta cell of small intestine - small intestine D-cell - small intestine delta cell - type D cell of small intestine - - - - - A type D cell of the small intestine. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A type D cell found in the stomach. - - 2010-09-10T01:36:03Z - FMA:83410 - delta cell of stomach - stomach D-cell - stomach delta cell - type D cell of stomach - - - - - A type D cell found in the stomach. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A PP cell located in the islets of the pancreas. - - - 2010-09-10T03:30:31Z - BTO:0000805 - FMA:70588 - MESH:D050418 - PP cell of pancreatic islet - PP-cell of pancreatic islet - pancreatic polypeptide-secreting cell - - The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell. - pancreatic PP cell - - - - - A PP cell located in the islets of the pancreas. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - An epithelial cell of a skin gland. - - 2010-09-14T12:00:07Z - FMA:70657 - epithelial cell of gland of skin - epithelial cell of skin gland - - - - - An epithelial cell of a skin gland. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - A cell that is part of the nervous system. - - 2010-09-15T01:34:57Z - CALOHA:TS-2040 - FMA:70333 - neural cell - - - - - A cell that is part of the nervous system. - GOC:tfm - ISBN:0618947256 - - - - - - - - - - - - - - - - - - - - - - - - - - A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone. - - 2010-09-15T03:01:54Z - CALOHA:TS-2096 - FMA:63875 - MESH:D003239 - connective tissue cell - - - - - A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone. - GOC:tfm - ISBN:0618947256 - - - - - - - - - A cell of the embryo. - - 2010-09-15T03:39:21Z - CALOHA:TS-0263 - FMA:82840 - FMA:82841 - WBbt:0007028 - embryonic cell (metazoa) - - - - - A cell of the embryo. - FMA:0618947256 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A fat cell derived from a neural crest cell. - - 2010-09-20T02:25:25Z - neural crest derived fat cell - - - - - A fat cell derived from a neural crest cell. - GOC:tfm - PMID:17507398 - - - - - - - - - - - - - - - - - - - - - - - - - - - An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin. - - - 2010-09-21T04:33:05Z - FMA:75621 - endocardial endothelial cell - endothelial cell of endocardium - - endocardial cell - - - - - - true - - - - - An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin. - GOC:tfm - ISSN:0452-3458 - - - - - endothelial cell of endocardium - FMA:75621 - - - - - - - - - A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1. - - 2010-09-21T04:41:06Z - pancreatic endocrine progenitor - pancreatic islet progenitor cell - progenitor cell of endocrine pancreas - - - - - A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1. - GOC:tfm - PMID:20025937 - PMID:20217494 - PMID:22728667 - - - - - - - - - - - - - - - - - - - - - - - - - - A hematopoietic stem cell that exists during embryogenesis. - - 2010-09-22T09:05:13Z - gestational hematopoietic stem cell - - - - - A hematopoietic stem cell that exists during embryogenesis. - GOC:tfm - ISBN:978-60327-246-6 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate. - - - 2010-09-22T01:57:40Z - corneal fibroblast - corneal keratocyte - - - keratocyte - - - - - - true - - - - - A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate. - GOC:tfm - ISBN:978-0-7020-2958-5 - - - - - - - - - - - - - - - - - - - - - - - - - - An endo-epithelial cell of the respiratory tract. - - 2010-09-23T04:38:49Z - BTO:0004533 - airway epithelial cell - respiratory epithelial cell - - - - - - true - - - - - An endo-epithelial cell of the respiratory tract. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A transversely striated, synctial muscle cell, formed by the fusion of myoblasts. - - 2010-09-24T01:13:01Z - FBbt:00005812 - myotubule - single cell sarcomere - myotube - - - - - A transversely striated, synctial muscle cell, formed by the fusion of myoblasts. - GOC:dos - GOC:tfm - ISBN:0323052908 - PMID:22274696 - - - - - - - - - - - - - - - - - - - - - - - - - - - A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles. - - 2010-10-15T09:24:05Z - nucleated reticulocyte - - - - - - true - - - - - A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles. - GOC:tfm - PMID:18182572 - PMID:9011180 - PMID:9046052 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes. - - 2010-10-15T09:24:08Z - CALOHA:TS-0864 - FMA:66785 - enucleated reticulocyte - - - - - - true - - - - - A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes. - GOC:tfm - ISBN:0-12203-052-4 - ISBN:0721601464 - - - - - - - - - - - - - - - - - - - - - - - - - - A cell located in the heart, including both muscle and non muscle cells. - - 2010-12-07T09:37:22Z - BTO:0001539 - CALOHA:TS-0115 - FMA:83808 - FMA:84791 - heart cell - From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart. - cardiocyte - - - - - A cell located in the heart, including both muscle and non muscle cells. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc - - 2010-12-07T04:03:56Z - BTO:0002441 - FMA:84639 - adventitial cell - - - - - A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell of the intestine. - - 2011-01-17T03:39:38Z - intestinal smooth muscle cell - enteric smooth muscle cell - - - - - - true - - - - - A smooth muscle cell of the intestine. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A fat cell that is part of subcutaneous adipose tissue. - - - 2011-02-21T02:51:22Z - subcutaneous adipocyte - - subcutaneous fat cell - - - - - - true - - - - - A fat cell that is part of subcutaneous adipose tissue. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes. - - 2011-02-28T01:20:20Z - small bile duct cholangiocyte - intrahepatic cholangiocyte - - - - - - true - - - - - An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes. - GOC:tfm - PMID:23720296 - - - - - small bile duct cholangiocyte - PMID:23720296 - - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell of the aorta. - - 2011-02-28T01:42:12Z - BTO:0004577 - aortic smooth muscle cell - - - - - - true - - - - - A smooth muscle cell of the aorta. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A mesenchymal stem cell that is part of the bone marrow. - - 2011-02-28T01:47:47Z - mesenchymal stem cell of the bone marrow - - - - - A mesenchymal stem cell that is part of the bone marrow. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - An endothelial cell that is part of the vein. - - - 2011-02-28T03:48:11Z - FMA:62104 - KUPO:0001099 - endothelial cell of vein - venous endothelial cell - - vein endothelial cell - - - - - - true - - - - - An endothelial cell that is part of the vein. - GOC:tfm - - - - - - - - - An endothelial progenitor cell that participates in angiogenesis during development. - - 2011-02-28T04:20:39Z - See CL:0002619. - embryonic blood vessel endothelial progenitor cell - - - - - An endothelial progenitor cell that participates in angiogenesis during development. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - A fibroblast of the aortic adventitia. - - 2011-02-28T04:43:41Z - fibroblast of the aortic adventitia - - - - - - true - - - - - A fibroblast of the aortic adventitia. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - A fibroblast that is part of the heart. - - 2011-02-28T04:57:44Z - cardiac fibroblast - fibroblast of cardiac tissue - - - - - - true - - - - - - true - - - - - A fibroblast that is part of the heart. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - 2011-02-28T05:05:33Z - fibroblast of dermis - - - - - - true - - - - - - - - - - - - - - - - - - - - - - - - - - - A fibroblast that is part of lung. - - 2011-02-28T05:11:03Z - BTO:0000764 - CALOHA:TS-0575 - fibroblast of lung - - - - - - true - - - - - A fibroblast that is part of lung. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A fibroblast of pulmonary artery. - - - 2011-02-28T05:22:27Z - - fibroblast of pulmonary artery - - - - - - true - - - - - A fibroblast of pulmonary artery. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An epithelial cell of the intestine. - - 2011-03-01T05:18:31Z - intestinal epithelial cell - - - - - An epithelial cell of the intestine. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - A mesenchymal stem cell of adipose tissue. - - 2011-03-01T09:57:17Z - mesenchymal stem cell of adipose - mesenchymal stem cell of adipose tissue - - - - - A mesenchymal stem cell of adipose tissue. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A mesenchymal stem cell of liver. - - 2011-03-01T09:58:51Z - hepatic mesenchymal stem cell - - - - - - true - - - - - A mesenchymal stem cell of liver. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A mesenchymal stem cell of the vertebrae. - - 2011-03-01T10:40:27Z - vertebral mesenchymal stem cell - - - - - - true - - - - - A mesenchymal stem cell of the vertebrae. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - A stromal cell of the pancreas. - - - 2011-03-02T02:40:41Z - - stromal cell of pancreas - - - - - - true - - - - - A stromal cell of the pancreas. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - A blood vessel endothelial cell that is part of the retina. - - - 2011-03-06T03:28:27Z - - - retinal blood vessel endothelial cell - - - - - - true - - - - - A blood vessel endothelial cell that is part of the retina. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell of the bachiocephalic vasculature. - - 2011-03-06T05:00:58Z - smooth muscle cell of the brachiocephalic vasculature - - - - - - true - - - - - A smooth muscle cell of the bachiocephalic vasculature. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - A vascular associated smooth muscle cell of the brain vasculature. - - 2011-03-06T05:01:20Z - smooth muscle cell of the brain vasculature - - - - - - true - - - - - A vascular associated smooth muscle cell of the brain vasculature. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle of the pulmonary artery. - - - 2011-03-06T05:01:28Z - BTO:0003336 - - smooth muscle cell of the pulmonary artery - - - - - - true - - - - - A smooth muscle of the pulmonary artery. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell of the subclavian artery. - - 2011-03-06T05:01:52Z - smooth muscle cell of the subclavian artery - - - - - - true - - - - - A smooth muscle cell of the subclavian artery. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - Smooth muscle cell of the carotid artery. - - 2011-03-06T05:01:56Z - smooth muscle cell of the carotid artery - - - - - - true - - - - - Smooth muscle cell of the carotid artery. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell of the esophagus. - - 2011-03-06T05:48:17Z - smooth muscle cell of the esophagus - - - - - - true - - - - - A smooth muscle cell of the esophagus. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A neuron of the raphe nuclei. - - 2011-03-06T07:42:06Z - raphe nuclei neuron - - - - - - true - - - - - A neuron of the raphe nuclei. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A neuron of the ventral spinal cord. - - 2011-03-06T07:46:03Z - neuron of the ventral spinal cord - - - - - - true - - - - - A neuron of the ventral spinal cord. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A fibroblast of skin. - - - 2011-03-14T12:31:49Z - BTO:0001255 - CALOHA:TS-0935 - - skin fibroblast - - - - - - true - - - - - A fibroblast of skin. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - 2011-06-21T12:29:31Z - epithelial cell of lower respiratory tract - - - - - - true - - - - - - - - - - - - - - - - - - - - - - - - - - - A glandular epithelial cell of the esophagus. - - 2011-07-08T03:55:57Z - FMA:86548 - glandular cell of esophagus - - - - - - true - - - - - - true - - - - - A glandular epithelial cell of the esophagus. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A glandular epithelial cell of the large intestine. - - 2011-07-08T04:03:01Z - FMA:87194 - glandular cell of the large intestine - - - - - - true - - - - - A glandular epithelial cell of the large intestine. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A glandular epithelial cell that is part of the stomach. - - 2011-07-11T01:20:35Z - CALOHA:TS-1284 - FMA:86554 - glandular cell of stomach - - - - - - true - - - - - A glandular epithelial cell that is part of the stomach. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - A myocardial endocrine cell that is part of the atrium. - - 2011-07-11T02:45:39Z - FMA:83389 - myocardial endocrine cell of atrium - - - - - - true - - - - - A myocardial endocrine cell that is part of the atrium. - GOC:tfm - - - - - - - - - A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart. - - 2011-07-11T03:15:38Z - cardiovascular progenitor cell - CPC - Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell. - cardioblast - - - - - A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart. - GOC:tfm - PMID:19745164 - - - - - cardiovascular progenitor cell - PMID:17519333 - PMID:19745164 - - - - - CPC - PMID:19745164 - - - - - - - - - - - - - - - - - A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells. - - 2011-08-16T02:38:01Z - retinal progenitor cell - - - - - A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells. - GOC:tfm - PMID:20959166 - PMID:21148186 - - - - - - - - - - - - - - - - - A neuroblast derived from a neural crest cell. - - 2011-08-22T09:24:15Z - neural crest derived neuroblast - - - - - A neuroblast derived from a neural crest cell. - GOC:tfm - PMID:17407019 - - - - - - - - - - - - - - - - - - - - - - - - - - - A PP cell found in intestine. - - 2011-09-27T11:59:01Z - PP cell of intestine - - - - - - true - - - - - A PP cell found in intestine. - GOC:tfm - PMID:2420136 - PMID:728970 - - - - - - - - - - - - - - - - - - - - - - - - - - A CNS interneuron located in the spinal cord. - Is_a interneuron, part_of UBERON:0002240. - spinal cord interneuron - - - - - - true - - - - - A CNS interneuron located in the spinal cord. - CL:CVS - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic. - somatic motor neuron - somatomotor neuron - - - - - A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic. - ZFIN:CVS - - - - - - - - - Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation. - hepatoblast - https://github.com/obophenotype/cell-ontology/issues/800 - - - - - Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation. - GOC:CVS - PMID:18356246 - PMID:20483998 - PMID:26798363 - https://orcid.org/0000-0003-1940-6740 - - - - - - - - - Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized). - - 2012-06-15T02:51:27Z - scleroblast - Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts) - skeletogenic cell - - - - - Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized). - GO_REF:0000034 - - - - - scleroblast - GO_REF:0000034 - - - - - - - - - - - - - - - - - - - - - - Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells. - - 2012-06-27T08:27:35Z - premigratory neural crest cell - - - - - Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells. - UBERONREF:0000002 - - - - - - - - - Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells. - - 2012-06-27T10:44:01Z - prechondroblast - - - - - Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells. - GO_REF:0000034 - - - - - - - - - Any muscle cell in which the fibers are not organised into sarcomeres. - non-striated muscle cell - - - - - Any muscle cell in which the fibers are not organised into sarcomeres. - GOC:DOS - - - - - - - - - Any hematopoietic cell that is a precursor of some other hematopoietic cell type. - hematopoietic precursor cell - - - - - Any hematopoietic cell that is a precursor of some other hematopoietic cell type. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. - MESH:D018485 - skeletal muscle fiber - - - - - A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. - GOC:tfm - ISBN:0323052908 - - - - - - - - - - - - - - - - - - - - - - - - - - A muscle cell that is part of some visceral muscle. - FBbt:00005070 - visceral muscle cell - - - - - A muscle cell that is part of some visceral muscle. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods. - striated visceral muscle cell - - - - - A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods. - transversely striated visceral muscle cell - - - - - A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers. - myogenic precursor cell - The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins. - adult skeletal muscle myoblast - - - - - A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers. - PMID:23303905 - - - - - myogenic precursor cell - PMID:23303905 - - - - - - - - - - - - - - - - - - - - - A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration. - - mesenchyme cell - - mesenchymal cell - - - - - - - - - - - - - - - - - - - - - - - - - - - - A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves. - endocardial cushion cell - - - - - A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves. - PMID:18816864 - - - - - - - - - - - - - - - - - - - - - - - - - - - An endocrine cell that is part of the pancreas. - - - pancreatic endocrine cell - - - - - An endocrine cell that is part of the pancreas. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter. - noradrenergic neuron - - - - - A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - 2017-07-09T19:12:36Z - visual system neuron - - - - - - - - - Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation. - - - 2020-02-29T17:33:55Z - - - mural cell - - - - - Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation. - Wiki:Mural_cell&oldid=930603194 - - - - - - - - - - - - - - - - - - - - - - - - - - - - 2020-02-29T17:37:00Z - microcirculation associated smooth muscle cell - - - - - - - - - - - - - - - - - - - - - - - - - - - A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord. - spinal sensory neuron - sensory neuron of spinal nerve - - - - - - true - - - - - A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord. - GOC:nv - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any cell in the compound eye, a light sensing organ composed of ommatidia. - GOC:pr - PMID:12021768 - compound eye retinal cell - - - - - - - - - - - - - - - - - - - - - - - - - - Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. - PMID:10702418 - - retinal cell - - - - - Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - - An enteroendocrine cell that is located in the small intestine. - - small intestine enteroendocrine cell - - enteroendocrine cell of small intestine - - - - - An enteroendocrine cell that is located in the small intestine. - http://orcid.org/0000-0003-3440-1876 - - - - - - - - - - - - - - - - - - - - - - - - - - A stromal cell found in the lamina propria of the large intestine. - - - stromal cell of lamina propria of large intestine - - - - - A stromal cell found in the lamina propria of the large intestine. - http://orcid.org/0000-0003-4183-8865 - - - - - - - - - - - - - - - - - - - - - - - - - - A stromal cell found in the lamina propria of the small intestine. - - - stromal cell of lamina propria of small intestine - - - - - A stromal cell found in the lamina propria of the small intestine. - http://orcid.org/0000-0003-4183-8865 - - - - - - - - - - - - - - - - - - - - - - - - - - - - A mesothelial cell that is part of the small intestine. - - - mesothelial cell of small intestine - - - - - A mesothelial cell that is part of the small intestine. - http://orcid.org/0000-0003-4183-8865 - - - - - - - - - - - - - - - - - - - - - - - - - - - - A mesothelial cell that is part of the colon. - - mesothelial cell of large intestine - - mesothelial cell of colon - - - - - A mesothelial cell that is part of the colon. - http://orcid.org/0000-0003-3440-1876 - http://orcid.org/0000-0003-4183-8865 - - - - - - - - - - - - - - - - - - - - - - - - - - A stromal cell found in the lamina propria of the colon. - - stromal cell of colon lamina propria - - stromal cell of lamina propria of colon - - - - - A stromal cell found in the lamina propria of the colon. - http://orcid.org/0000-0003-3440-1876 - - - - - - - - - - - - - - - - - - - - - - - - - - - An enteroendocrine cell that is located in the colon. - - colon enteroendocrine cell - - enteroendocrine cell of colon - - - - - An enteroendocrine cell that is located in the colon. - http://orcid.org/0000-0003-3440-1876 - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell that is located in the anorectum. - - anorectum smooth muscle cell - - smooth muscle cell of anorectum - - - - - A smooth muscle cell that is located in the anorectum. - http://orcid.org/0000-0003-3440-1876 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A stromal cell found in the lamina propria of the anorectum. - - - stromal cell of anorectum lamina propria - - - - - A stromal cell found in the lamina propria of the anorectum. - http://orcid.org/0000-0003-3440-1876 - - - - - - - - - - - - - - - - - - - - - - - - - - - An enteroendocrine cell that is located in the anorectum. - - anorectum enteroendocrine cell - - enteroendocrine cell of anorectum - - - - - An enteroendocrine cell that is located in the anorectum. - http://orcid.org/0000-0003-3440-1876 - - - - - - - - - - - - - - - - - - - - - - - - - - An endothelial cell that is part of a hepatic portal vein. - - 2021-12-13T14:01:05Z - portal endothelial cell - EFO:0010704 - - endothelial cell of hepatic portal vein - - - - - An endothelial cell that is part of a hepatic portal vein. - PMID:30348985 - https://orcid.org/0000-0003-3440-1876 - https://orcid.org/0000-0003-4183-8865 - - - - - - - - - - - - - - - - - - - - - - - - - - A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development. - - 2022-02-21T15:39:10Z - embryonic skeletal muscle fiber - - - - - A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development. - PMID:32094117 - PMID:7196501 - http://orcid.org/0000-0003-2034-601X - - - - - - - - - - - - - - - - - - - - - - - - - - - A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen. - - - 2022-03-17T12:00:44Z - portal fibroblast - - hepatic portal fibroblast - - - - - A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen. - PMID:20209607 - PMID:24814904 - https://orcid.org/0000-0001-7655-4833 - - - - - - - - - - - - - - - - - - - - - - - - - - - A stromal cell that is part_of a bone marrow. - - bone marrow stromal cell - stromal cell of bone marrow - - - - - - - - - - - - - - - - - - - - - - - - - - - A mononuclear cell that is part_of a bone marrow. - - bone marrow mononuclear cell - mononuclear cell of bone marrow - - - - - - - - - - - - - - - - - - - - - - - - - - - cardiac blood vessel endothelial cell - - - - - - - - - - - - - - - - - - - - - - - - - - - His-Purkinje system cell - - - - - - - - - - - - - - - - - - - - - - - - - - - - - cardiac endothelial cell - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - camera type eye photoreceptor cell - camera-type eye photoreceptor cell - - - - - - - - - A zygote in a plant or an animal. - MESH:D015053 - zygote - - - - - - - - - - - - - - - - - - - - - - - - - - - - - cardiac glial cell - - - - - - - - - - - - - - - - - - - - - - - - - - MESH:D032386 - cardiac myoblast - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A neuron that has its soma in the heart. - This term is used in 3 GO terms that were created as part of the heart development focus project. - cardiac neuron - https://github.com/obophenotype/cell-ontology/pull/1488 - - - - - A neuron that has its soma in the heart. - PMID:12486170 - PMID:29265764 - - - - - - - - - - - - - - - - - - - - - - - - - - - A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement. - spinal cord motor neuron - - - - - - true - - - - - A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement. - GOC:nv - - - - - - - - - - - - - - - - - - - - - - - - - - A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites. - paraxial mesoderm cell - somitic mesoderm cell - presomitic mesoderm cell - paraxial cell - - - - - A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites. - GOC:NV - PMID:11687492 - - - - - - - - - - A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells. - neural crest cell - - - - - A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells. - https://orcid.org/0000-0001-5208-3432 - https://orcid.org/0000-0002-9900-7880 - - - - - - - - - - - - - - - - - - - - - - - - - - - A mesothelial cell that is part of the epicardium. - - mesothelial cell of epicardium - - - - - - - - - - - - - - - - - - - - - - - - - - A fibroblast that is part of upper back skin. - - fibroblast of upper back skin - - - - - - - - - - - - - - - - - - - - - - - - - - A fibroblast that is part of skin of back. - - fibroblast of skin of back - - - - - - - - - - - - - - - - - - - - - - - - - - A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses. - - progenitor cell - - - - - A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses. - ISBN:978-1-62808-994-3 - https://doi.org/10.1016/B978-0-12-409503-8.00002-0 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any fibroblast that is part of skeletal muscle tissue. - - skeleton muscle fibroblast - skeletal muscle fibroblast - - - - - Any fibroblast that is part of skeletal muscle tissue. - PMID:28369879 - https://orcid.org/0000-0001-6164-0667 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any microvascular endothelial cell that is part of the dermis. - - DMEC cell - dermal microvascular endothelium cell - dermal microvascular endothelial cell - - - - - Any microvascular endothelial cell that is part of the dermis. - BTO:0004574 - CL:patterns/cellPartOfAnatomicalEntity - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Epithelial cell that is part of the colon epithelium. - colonic epithelial cell - colon epithelial cell - - - - - Epithelial cell that is part of the colon epithelium. - GOC:NV - - - - - - - - - - - - - - - - - - - - - - - - - - A cell that, by division or terminal differentiation, can give rise to other cell types. - Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell. - precursor cell - - - - - A cell that, by division or terminal differentiation, can give rise to other cell types. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain. - - 2009-12-22T04:23:25Z - eosinophilic - acidophilic cytoplasm - - - - - Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions. - - 2009-12-22T04:24:54Z - basophilic cytoplasm - - - - - Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions. - - 2009-12-28T04:25:23Z - polychromatophilic cytoplasm - - - - - Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell. - - 2009-12-23T10:53:24Z - increased nucleus size - - - - - A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell that is part of any blood vessel. - - - 2020-07-21T12:42:48Z - smooth muscle cell of blood vessel - - blood vessel smooth muscle cell - - - - - A smooth muscle cell that is part of any blood vessel. - PMID:9108778 - - - - - - - - - - - - - - - - - - - - - - - - - - An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes. - - 2020-09-03T12:24:24Z - large bile duct cholangiocyte - extrahepatic cholangiocyte - - - - - An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes. - PMID:23720296 - - - - - large bile duct cholangiocyte - PMID:23720296 - - - - - - - - - - - - - - - - - - - - - - - - - - An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid. - - 2020-09-09T13:56:47Z - EFO:0010705 - periportal LSEC - periportal hepatic sinusoidal endothelial cell - endothelial cell of periportal hepatic sinusoid - - - - - An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid. - PMID:27423426 - - - - - periportal LSEC - PMID:28287163 - - - - - periportal hepatic sinusoidal endothelial cell - PMID:30348985 - - - - - - - - - - - - - - - - - - - - - - - - - - An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid. - - 2020-09-10T12:38:29Z - EFO:0010706 - central venous hepatic sinusoidal endothelial cell - pericentral LSEC - endothelial cell of pericentral hepatic sinusoid - - - - - An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid. - PMID:27423426 - - - - - central venous hepatic sinusoidal endothelial cell - PMID:30348985 - - - - - pericentral LSEC - PMID:28287163 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - stomach neuroendocrine cell - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury. - - pulmonary neuroendocrine cell - PNEC - - lung neuroendocrine cell - - - - - A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury. - PMID:33355253 - doi:10.3109/01902148209069653 - doi:10.7554/eLife.78216 - - - - - pulmonary neuroendocrine cell - PMID:33355253 - - - - - PNEC - PMID:33355253 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - lung ciliated cell - - - - - - - - - - - - - - - - - - - - - - - - - - - lung secretory cell - - - - - - - - - trophectoderm cell - trophectodermal cell - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell that is part of the small intestine. - FMA:15050 - non-striated muscle fiber of small intestine - smooth muscle cell of small intestine - - - - - - true - - - - - A smooth muscle cell that is part of the small intestine. - GOC:tfm - - - - - non-striated muscle fiber of small intestine - FMA:15050 - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell that is part of the duodenum. - FMA:15058 - non-striated muscle fiber of duodenum - smooth muscle fiber of duodenum - - - - - - true - - - - - A smooth muscle cell that is part of the duodenum. - GOC:tfm - - - - - non-striated muscle fiber of duodenum - FMA:15058 - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell that is part of the large intestine. - - FMA:15653 - non-striated muscle fiber of large intestine - - smooth muscle cell of large intestine - - - - - - true - - - - - A smooth muscle cell that is part of the large intestine. - GOC:tfm - - - - - non-striated muscle fiber of large intestine - FMA:15653 - - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell that is part of the colon. - FMA:15663 - non-striated muscle fiber of colon - smooth muscle cell of colon - - - - - - true - - - - - A smooth muscle cell that is part of the colon. - GOC:tfm - - - - - non-striated muscle fiber of colon - FMA:15663 - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell that is part of the sigmoid colon. - FMA:17521 - non-striated muscle fiber of sigmoid colon - smooth muscle cell of sigmoid colon - - - - - - true - - - - - A smooth muscle cell that is part of the sigmoid colon. - GOC:tfm - - - - - non-striated muscle fiber of sigmoid colon - FMA:17521 - - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell that is part of the rectum. - FMA:17522 - non-striated muscle fiber of rectum - smooth muscle fiber of rectum - smooth muscle cell of rectum - - - - - - true - - - - - A smooth muscle cell that is part of the rectum. - GOC:tfm - - - - - non-striated muscle fiber of rectum - FMA:17522 - - - - - - - - - - - - - - - - - - - - - - - - - - A fibroblast that is part of the areolar connective tissue. - FMA:261279 - fibroblast of areolar connective tissue - - - - - - true - - - - - A fibroblast that is part of the areolar connective tissue. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - A fibroblast that is part of the tunica adventitia of artery. - FMA:261285 - fibroblast of tunica adventitia of artery - - - - - - true - - - - - A fibroblast that is part of the tunica adventitia of artery. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A fibroblast that is part of the dense regular elastic tissue. - FMA:261287 - fibroblast of dense regular elastic tissue - - - - - A fibroblast that is part of the dense regular elastic tissue. - GOC:tfm - - - - - - - - - - - - - - - - - A fat cell that is part of the epicardial fat. - - FMA:261293 - adipocyte of epicardial fat - epicardial fat cell - - epicardial adipocyte - - - - - A fat cell that is part of the epicardial fat. - GOC:tfm - - - - - adipocyte of epicardial fat - FMA:261293 - - - - - epicardial fat cell - FMA:261293 - - - - - - - - - - - - - - - - - - - - - - - - - - - A fat cell that is part of the epicardial fat of right ventricle. - FMA:261297 - epicardial adipocyte of right ventricle - epicardial fat cell of right ventricle - adipocyte of epicardial fat of right ventricle - - - - - - true - - - - - A fat cell that is part of the epicardial fat of right ventricle. - GOC:tfm - - - - - epicardial adipocyte of right ventricle - FMA:261297 - - - - - epicardial fat cell of right ventricle - FMA:261297 - - - - - - - - - - - - - - - - - - - - - - - - - - - A fat cell that is part of the epicardial fat of left ventricle. - FMA:261300 - epicardial adipocyte of left ventricle - epicardial fat cell of left ventricle - adipocyte of epicardial fat of left ventricle - - - - - - true - - - - - A fat cell that is part of the epicardial fat of left ventricle. - GOC:tfm - - - - - epicardial adipocyte of left ventricle - FMA:261300 - - - - - epicardial fat cell of left ventricle - FMA:261300 - - - - - - - - - - - - - - - - - - - - - - - - - - - A transitional myocyte that is part of the interatrial septum. - FMA:263152 - transitional myocyte of interatrial septum - - - - - - true - - - - - A transitional myocyte that is part of the interatrial septum. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A transitional myocyte that is part of the interventricular septum. - FMA:263154 - transitional myocyte of interventricular septum - - - - - - true - - - - - A transitional myocyte that is part of the interventricular septum. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A Purkinje myocyte that is part of the interventricular septum. - FMA:263182 - Purkinje myocyte of interventricular septum - - - - - - true - - - - - A Purkinje myocyte that is part of the interventricular septum. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates. - - BTO:000125 - FMA:62911 - LSEC - endotheliocyte of hepatic sinusoid - liver sinusoidal endothelial cell - - endothelial cell of hepatic sinusoid - - - - - An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates. - GOC:tfm - PMID:3926620 - - - - - LSEC - PMID:30348985 - - - - - endotheliocyte of hepatic sinusoid - FMA:62911 - - - - - liver sinusoidal endothelial cell - PMID:30348985 - - - - - - - - - - - - - - - - - - - - - - - - - - - A muscle cell that is part of the sinoatrial node. - FMA:67102 - SA nodal myocyte - SA node cardiac muscle cell - sinoatrial node cell - sinoatrial node myocyte - sinuatrial node myocyte - myocyte of sinoatrial node - - - - - A muscle cell that is part of the sinoatrial node. - FMA:67102 - GOC:tfm - - - - - SA nodal myocyte - FMA:67102 - - - - - SA node cardiac muscle cell - GOC:pr - - - - - sinoatrial node cell - GOC:pr - - - - - sinuatrial node myocyte - FMA:67102 - - - - - - - - - - - - - - - - - - - - - - - - - - - - A muscle cell that is part of the atrioventricular node. - FMA:67106 - AV nodal myocyte - AV node cardiac muscle cell - AV node cell - atrioventricular node cell - atrioventricular node myocyte - myocyte of atrioventricular node - - - - - A muscle cell that is part of the atrioventricular node. - FMA:67106 - GOC:tfm - - - - - AV nodal myocyte - FMA:67106 - - - - - AV node cardiac muscle cell - GOC:pr - - - - - AV node cell - GOC:pr - - - - - atrioventricular node cell - GOC:pr - - - - - atrioventricular node myocyte - FMA:67106 - - - - - - - - - - - - - - - - - - - - - - - - - - An endothelial cell that is part of the arteriole. - - FMA:67760 - KUPO:0001097 - - endothelial cell of arteriole - - - - - - true - - - - - An endothelial cell that is part of the arteriole. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A blood vessel endothelial cell that is part of an arterial endothelium. - - BTO:0004758 - FMA:67761 - KUPO:0001095 - arterial endothelial cell - - endothelial cell of artery - - - - - A blood vessel endothelial cell that is part of an arterial endothelium. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - An endothelial cell that is part of the venule. - - FMA:67762 - - endothelial cell of venule - - - - - - true - - - - - An endothelial cell that is part of the venule. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - An epithelial cell that is part of the gallbladder. - FMA:67780 - epithelial cell of gallbladder - - - - - An epithelial cell that is part of the gallbladder. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A somatic stem cell that is part of the epidermis. - FMA:70541 - epidermal stem cell - stem cell of epidermis - - - - - - true - - - - - A somatic stem cell that is part of the epidermis. - GOC:tfm - - - - - epidermal stem cell - FMA:70541 - - - - - - - - - - - - - - - - - - - - - - - - - - - A smooth muscle cell that is part of the ciliary body. - FMA:70610 - smooth muscle cell of ciliary body - - ciliary muscle cell - - - - - - true - - - - - A smooth muscle cell that is part of the ciliary body. - GOC:tfm - - - - - smooth muscle cell of ciliary body - FMA:70610 - - - - - - - - - - - - - - - - - - - - - - - - - - - A mesothelial cell that is part of the anterior chamber of eyeball. - FMA:70615 - mesothelial cell of anterior chamber of eye - - - - - A mesothelial cell that is part of the anterior chamber of eyeball. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - A mesothelial cell that is part of the parietal peritoneum. - FMA:72142 - mesothelial cell of parietal peritoneum - - - - - A mesothelial cell that is part of the parietal peritoneum. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - A mesothelial cell that is part of the visceral peritoneum. - - FMA:72143 - - mesothelial cell of visceral peritoneum - - - - - A mesothelial cell that is part of the visceral peritoneum. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A transitional myocyte that is part of the sinoatrial node. - FMA:83384 - transitinal myocyte of sinuatrial node - transitional myocyte of sinoatrial node - - - - - - true - - - - - A transitional myocyte that is part of the sinoatrial node. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A Purkinje myocyte that is part of the atrioventricular node. - FMA:83386 - Purkinje myocyte of atrioventricular node - - - - - - true - - - - - A Purkinje myocyte that is part of the atrioventricular node. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A myocardial endocrine cell that is part of the interventricular septum. - FMA:83390 - myocardial endocrine cell of interventricular septum - - - - - - true - - - - - A myocardial endocrine cell that is part of the interventricular septum. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts. - FMA:86481 - epithelial cell of bile duct - cholangiocyte - - - - - - true - - - - - An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts. - GOC:tfm - PMID:16550043 - PMID:18356246 - - - - - - - - - - - - - - - - - - - - - - - - - - A mesothelial cell that is part of the peritoneum. - FMA:86736 - peritoneal mesothelial cell - mesothelial cell of peritoneum - - - - - A mesothelial cell that is part of the peritoneum. - GOC:tfm - - - - - peritoneal mesothelial cell - FMA:86736 - - - - - - - - - - - - - - - - - - - - - - - - - - - A mesothelial cell that is part of the pleura. - FMA:86737 - pleural mesothelial cell - mesothelial cell of pleura - - - - - A mesothelial cell that is part of the pleura. - GOC:tfm - - - - - pleural mesothelial cell - FMA:86737 - - - - - - - - - - - - - - - - - - - - - - - - - - A mesothelial cell that is part of the parietal pleura. - FMA:86738 - mesothelial cell of parietal pleura - - - - - A mesothelial cell that is part of the parietal pleura. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - A mesothelial cell that is part of the visceral pleura. - - FMA:86739 - - mesothelial cell of visceral pleura - - - - - A mesothelial cell that is part of the visceral pleura. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - An epithelial cell of the exocrine pancreas. - - FMA:70986 - exocrine pancreas cell - - epithelial cell of exocrine pancreas - - - - - An epithelial cell of the exocrine pancreas. - GOC:tfm - - - - - - - - - - - - - - - - - - - - - - - - - - - The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract. - intestinal enteroendocrine cell - - - - - The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract. - MP:0010802 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - endothelial cell of lung - pulmonary vessel endothelial cell - lung endothelial cell - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - BTO:0001141 - PAEC cell - - pulmonary artery endothelial cell - - - - - PAEC cell - BTO:0001141 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A vascular endothelial cell found in colon blood vessels. - CALOHA:TS-2397 - colon endothelial cells - colonic endothelial cell - colon endothelial cell - - - - - A vascular endothelial cell found in colon blood vessels. - NPX:PDR - https://orcid.org/0000-0001-5208-3432 - - - - - colon endothelial cells - CALOHA:TS-2397 - - - - - - colonic endothelial cell - CALOHA:TS-2397 - - - - - - - - - - - - - - - - - - - - - - - - - - - Squamous cell of oral epithelium. - CALOHA:TS-1252 - oral cavity mucosa squamous cell - oral cavity mucosa squamous epithelial cell - oral mucosa squamous epithelial cell - oral mucosa squamous epithelial cells - oral mucosa squamous cell - - - - - Squamous cell of oral epithelium. - NPX:PDR - - - - - oral cavity mucosa squamous cell - CALOHA:TS-1252 - - - - - oral cavity mucosa squamous epithelial cell - CALOHA:TS-1252 - - - - - oral mucosa squamous epithelial cell - CALOHA:TS-1252 - - - - - oral mucosa squamous epithelial cells - CALOHA:TS-1252 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells. - CALOHA:TS-1274 - colon glandular cells - colon glandular cell - - - - - Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells. - NPX:PDR - - - - - colon glandular cells - CALOHA:TS-1274 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell. - CALOHA:TS-1275 - duodenum glandular cells - duodenum glandular cell - - - - - Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell. - NPX:PDR - - - - - duodenum glandular cells - CALOHA:TS-1275 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Glandular cell of gallbladder epithelium. - CALOHA:TS-1278 - gall bladder glandular cell - gall bladder glandular cells - gallbladder glandular cells - gallbladder glandular cell - - - - - Glandular cell of gallbladder epithelium. - NPX:PDR - - - - - gall bladder glandular cell - FMA:7202 - - - - - gall bladder glandular cells - CALOHA:TS-1278 - - - - - gallbladder glandular cells - CALOHA:TS-1278 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells. - CALOHA:TS-1281 - rectal glandular cell - rectum glandular cells - rectum glandular cell - - - - - Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells. - NPX:PDR - - - - - rectal glandular cell - CALOHA:TS-1281 - - - - - rectum glandular cells - CALOHA:TS-1281 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) . - CALOHA:TS-1286 - FMA:86928 - small bowel glandular cell - small intestinal glandular cell - small intestine glandular cells - small intestine glandular cell - - - - - A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) . - NCI_Thesaurus:Small_Intestinal_Glandular_Cell - NPX:PDR - - - - - small bowel glandular cell - CALOHA:TS-1286 - - - - - small intestinal glandular cell - CALOHA:TS-1286 - - - - - small intestine glandular cells - CALOHA:TS-1286 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts. - - BTO:0000028 - CALOHA:TS-1242 - exocrine pancreas glandular cell - pancreas exocrine glandular cells - - pancreas exocrine glandular cell - - - - - Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts. - HPA:HPA - NPX:PDR - - - - - exocrine pancreas glandular cell - CALOHA:TS-1242 - - - - - pancreas exocrine glandular cells - CALOHA:TS-1242 - - - - - - - - - - - - - - - - - - - - - - - - - - Fibroblast from muscle organ. - CALOHA:TS-0643 - muscle fibroblast - - - - - Fibroblast from muscle organ. - NPX:PDR - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes. - CALOHA:TS-2109 - bone marrow hematopoietic cells - bone marrow poietic cells - bone marrow hematopoietic cell - - - - - Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes. - NPX:PDR - - - - - bone marrow hematopoietic cells - CALOHA:TS-2109 - - - - - bone marrow poietic cells - CALOHA:TS-2109 - - - - - - - - - - - - - - - - - - - - - - - - - - - - A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood. - - 2014-02-11T17:29:04Z - CL:2000001 - peripheral blood mononuclear cell - - - - - A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any blood vessel endothelial cell that is part of a microvascular endothelium. - - 2014-06-04T15:07:42Z - CL:2000008 - microvascular endothelial cell - - - - - Any blood vessel endothelial cell that is part of a microvascular endothelium. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any blood vessel endothelial cell that is part of a dermis. - - 2014-06-04T15:12:06Z - CL:2000010 - dermis blood vessel endothelial cell - - - - - Any blood vessel endothelial cell that is part of a dermis. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any skin fibroblast that is part of a skin of abdomen. - - 2014-06-04T15:18:16Z - CL:2000013 - fibroblast of skin of abdomen - - - - - Any skin fibroblast that is part of a skin of abdomen. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any lung endothelial cell that is part of a microvascular endothelium. - - 2014-06-04T16:00:56Z - CL:2000016 - lung microvascular endothelial cell - - - - - Any lung endothelial cell that is part of a microvascular endothelium. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any photoreceptor cell that is part of a compound eye. - - 2014-06-24T23:16:45Z - FBbt:00004211 - CL:2000019 - compound eye photoreceptor cell - - - - - Any photoreceptor cell that is part of a compound eye. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any native cell that is part of a inner cell mass. - - 2014-06-24T23:16:53Z - CL:2000020 - inner cell mass cell - - - - - Any native cell that is part of a inner cell mass. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any native cell that is part of a cardiac septum. - - 2014-06-24T23:17:07Z - CL:2000022 - cardiac septum cell - - - - - Any native cell that is part of a cardiac septum. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any neuron that is part of a central nervous system. - - 2014-06-25T01:17:43Z - CL:2000029 - central nervous system neuron - - - - - Any neuron that is part of a central nervous system. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - A neuron that is part of a peripheral nervous system. - - 2014-06-25T02:28:17Z - FMA:84664 - PNS neuron - peripheral neuron - CL:2000032 - peripheral nervous system neuron - - - - - A neuron that is part of a peripheral nervous system. - GOC:TermGenie - ISBN:0721662544 - - - - - - - - - - - - - - - - - - - - - - - - - - Any fibroblast that is part of a embryo. - - 2014-07-09T00:12:00Z - CL:2000042 - embryonic fibroblast - - - - - Any fibroblast that is part of a embryo. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any microvascular endothelial cell that is part of a brain. - - 2014-07-09T00:24:53Z - CL:2000044 - brain microvascular endothelial cell - - - - - Any microvascular endothelial cell that is part of a brain. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any cardiac muscle cell that is part of a cardiac ventricle. - - 2014-08-12T20:50:28Z - CL:2000046 - ventricular cardiac muscle cell - - - - - Any cardiac muscle cell that is part of a cardiac ventricle. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any motor neuron that is part of a brainstem. - - 2014-10-02T23:52:53Z - CL:2000047 - brainstem motor neuron - - - - - Any motor neuron that is part of a brainstem. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any fibroblast that is part of a spleen. - - 2014-10-06T18:58:47Z - CL:2000051 - splenic fibroblast - - - - - Any fibroblast that is part of a spleen. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any endothelial cell that is part of a spleen. - - - 2014-10-06T19:06:04Z - CL:2000053 - - http://www.sciencellonline.com/site/productInformation.php?keyword=5500 - splenic endothelial cell - - - - - Any endothelial cell that is part of a spleen. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any fibroblast that is part of a female gonad. - - 2014-10-07T17:57:42Z - CL:2000063 - http://www.sciencellonline.com/site/productInformation.php?keyword=7330 - ovarian fibroblast - - - - - Any fibroblast that is part of a female gonad. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any epithelial cell that is part of a female gonad. - - 2014-10-07T17:59:13Z - CL:2000064 - http://www.sciencellonline.com/site/productInformation.php?keyword=7310 - ovarian surface epithelial cell - - - - - Any epithelial cell that is part of a female gonad. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any fibroblast that is part of a cardiac ventricle. - - - 2014-10-07T18:35:38Z - CL:2000066 - - http://www.sciencellonline.com/site/productInformation.php?keyword=6310 - cardiac ventricle fibroblast - - - - - Any fibroblast that is part of a cardiac ventricle. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any fibroblast that is part of a cardiac atrium. - - - 2014-10-07T18:36:54Z - CL:2000067 - - http://www.sciencellonline.com/site/productInformation.php?keyword=6320 - cardiac atrium fibroblast - - - - - Any fibroblast that is part of a cardiac atrium. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any fibroblast that is part of a pericardium. - - 2014-10-07T18:38:06Z - CL:2000068 - http://www.sciencellonline.com/site/productInformation.php?keyword=6430 - pericardium fibroblast - - - - - Any fibroblast that is part of a pericardium. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any fibroblast that is part of a gallbladder. - - 2014-10-07T18:41:43Z - CL:2000069 - http://www.sciencellonline.com/site/productInformation.php?keyword=5430 - gallbladder fibroblast - - - - - Any fibroblast that is part of a gallbladder. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any fibroblast that is part of a optic choroid. - - 2014-10-07T18:50:43Z - CL:2000070 - http://www.sciencellonline.com/site/productInformation.php?keyword=6620 - optic choroid fibroblast - - - - - Any fibroblast that is part of a optic choroid. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any microvascular endothelial cell that is part of a adipose tissue. - - 2014-10-07T22:13:45Z - CL:2000072 - http://www.sciencellonline.com/site/productInformation.php?keyword=7200 - adipose microvascular endothelial cell - - - - - Any microvascular endothelial cell that is part of a adipose tissue. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any migratory neural crest cell that is part of a cardiac neural crest. - - 2014-11-05T01:18:43Z - cardiac neural crest cell - CL:2000073 - migratory cardiac neural crest cell - - - - - Any migratory neural crest cell that is part of a cardiac neural crest. - GOC:TermGenie - - - - - cardiac neural crest cell - PMID:33060096 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any leukocyte that is part of a spleen. - - 2014-11-05T01:26:50Z - CL:2000074 - Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology. - splenocyte - - - - - Any leukocyte that is part of a spleen. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any mesenchymal stem cell of adipose tissue that is part of an abdomen. - - 2014-12-02T19:10:34Z - mesenchymal stem cell of abdominal adipose - CL:2000080 - mesenchymal stem cell of abdominal adipose tissue - - - - - Any mesenchymal stem cell of adipose tissue that is part of an abdomen. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - A ciliated epithelial cell of the esophagus. - - 2019-02-09T16:40:30Z - CL:3000000 - ciliated epithelial cell of esophagus - - - - - A ciliated epithelial cell of the esophagus. - GOC:CellBLAST - PMID:29802404 - - - - - - - - - - - - - - - - - - - - - - - - - - - Peripheral sensory neuron. - - 2019-02-25T19:34:33Z - CL:3000004 - peripheral sensory neuron - - - - - Peripheral sensory neuron. - GOC:CellBLAST - PMID:30096314 - - - - - - - - - - - - - - - - - - - - - - - - - - - A cell that is part of the brain vasculature. - - - - brain vascular cell - - - - - A cell that is part of the brain vasculature. - DOI:10.1101/2022.10.12.511898 - - - - - - - - - - - - - - - - - - - - - - - - - - - A GABAergic inhibitory neuron that is derived from the midbrain. - - - - midbrain-derived inhibitory neuron - - - - - A GABAergic inhibitory neuron that is derived from the midbrain. - DOI:10.1101/2022.10.12.511898 - - - - - - - - - - - - - - - - - - - - - - - - - - A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli. - - somatosensory neuron - - - - - A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli. - PMID:22865660 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any capillary endothelial cell that is part of a lung. - - 2021-11-23T02:31:40Z - lung capillary endothelial cell - pulmonary capillary endothelial cell - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium. - 2023-01-25T11:06:01Z - ciliated cell of the respiratory tract - respiratory ciliated cell - - - - - A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium. - PMID:18757316 - PMID:21364219 - - - - - - - - - - - - - - - - - - - - - - - - - - A(n) vein endothelial cell that is part of a(n) respiratory system. - - - - vein endothelial cell of respiratory system - - - - - A(n) vein endothelial cell that is part of a(n) respiratory system. - PMID:34030460 - - - - - - - - - - - - - - - - - - - - - - - - - - - - A megakaryocyte that is resident in the lung connective tissue. - - - - 2023-03-16T11:31:23Z - lung resident megakaryocyte - lung-resident megakaryocyte - MKL - lung MKs - - lung megakaryocyte - - - - - A megakaryocyte that is resident in the lung connective tissue. - PMID:33351116 - - - - - lung resident megakaryocyte - PMID:36524131 - - - - - lung-resident megakaryocyte - PMID:36524131 - - - - - MKL - PMID:36524131 - - - - - - lung MKs - PMID:33351116 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A neuron that releases catecholamine as a neurotransmitter. - - 2023-05-18T12:07:45Z - Frequently used when describing the developing nervous system in zebrafish. A catecholaminergic neuron expresses tyrosine hydroxylase (TH), tyrosine hydroxylase 2 (TH2), aromatic amino acid decarboxylase (AADC), dopamine b-hydroxylase (DBH), and phenylethanolamine-N-methyl transferase (PEMT), which are enzymes necessary for catecholamine synthesis. - catecholaminergic neuron - - - - - A neuron that releases catecholamine as a neurotransmitter. - ISBN:0521442516 - PMID:12094209 - - - - - Frequently used when describing the developing nervous system in zebrafish. A catecholaminergic neuron expresses tyrosine hydroxylase (TH), tyrosine hydroxylase 2 (TH2), aromatic amino acid decarboxylase (AADC), dopamine b-hydroxylase (DBH), and phenylethanolamine-N-methyl transferase (PEMT), which are enzymes necessary for catecholamine synthesis. - PMID:10191060 - PMID:12128258 - PMID:34880760 - https://orcid.org/0000-0002-2244-7917 - - - - - - - - - - - - - - - - - - - - - - - - - - A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics. - - 2023-08-22T13:40:28Z - perivascular cell - - - - - A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics. - PMID:24928499 - PMID:27889329 - - - - - - - - - - - - - - - - - - - - - - - - - - Any mesenchymal stem cell of adipose tissue that is part of an orbital region. - - 2023-09-18T10:43:00Z - OAMSC - Orbital ASCs - orbital adipose-derived mesenchymal stem cell - mesenchymal stem cell of orbital adipose tissue - - - - - Any mesenchymal stem cell of adipose tissue that is part of an orbital region. - - - - - - OAMSC - PMID:31377878 - - - - - Orbital ASCs - PMID:30210548 - - - - - orbital adipose-derived mesenchymal stem cell - PMID:31377878 - - - - - - - - - The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. - GO:0019952 - GO:0050876 - Wikipedia:Reproduction - reproductive physiological process - biological_process - GO:0000003 - - - - - - reproduction - - - - - The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. - GOC:go_curators - GOC:isa_complete - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton. - - biological_process - GO:0000011 - vacuole inheritance - - - - - The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton. - GOC:mcc - PMID:10873824 - PMID:14616069 - - - - - - - - - - - - - - - - - - - - - - - - - - - The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. - GO:0016359 - mitotic chromosome segregation - mitotic sister-chromatid adhesion release - biological_process - GO:0000070 - - mitotic sister chromatid segregation - - - - - The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. - GOC:ai - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The lipid bilayer surrounding any of the compartments of the Golgi apparatus. - Golgi apparatus membrane - cellular_component - GO:0000139 - Golgi membrane - - - - - The lipid bilayer surrounding any of the compartments of the Golgi apparatus. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. - https://github.com/geneontology/go-ontology/issues/23114 - https://github.com/geneontology/go-ontology/issues/23195 - microtubule cytoskeleton organisation - biological_process - microtubule cytoskeleton organization and biogenesis - GO:0000226 - - microtubule cytoskeleton organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. - GOC:mah - - - - - microtubule cytoskeleton organisation - GOC:mah - - - - - microtubule cytoskeleton organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. - nuclear interphase chromosome - cellular_component - GO:0000228 - - - nuclear chromosome - - - - - A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. - GOC:dph - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. - glycan biosynthesis - glycan biosynthetic process - polysaccharide anabolism - polysaccharide biosynthesis - polysaccharide formation - polysaccharide synthesis - biological_process - GO:0000271 - polysaccharide biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. - GO:0044244 - polysaccharide breakdown - polysaccharide catabolism - polysaccharide degradation - multicellular organismal polysaccharide catabolic process - biological_process - GO:0000272 - polysaccharide catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. - PMID:33139480 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. - GO:0007067 - Wikipedia:Mitosis - biological_process - mitosis - GO:0000278 - - - - - Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. - mitotic cell cycle - - - - - Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. - GOC:mah - ISBN:0815316194 - Reactome:69278 - - - - - - - - - - - - - - - - - - - - - - - - - - The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. - biological_process - karyokinesis - GO:0000280 - - nuclear division - - - - - The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A ribosome contained within a subcellular membrane-bounded organelle. - cellular_component - GO:0000313 - organellar ribosome - - - - - A ribosome contained within a subcellular membrane-bounded organelle. - GOC:mah - GOC:mcc - - - - - - - - - - - - - - - - - - - - - - - - - - - The joining of 2 or more lipid bilayer membranes that surround the nucleus. - biological_process - GO:0000740 - nuclear membrane fusion - - - - - The joining of 2 or more lipid bilayer membranes that surround the nucleus. - GOC:elh - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. - GO:0007335 - Wikipedia:Karyogamy - nuclear fusion - nuclear fusion during karyogamy - biological_process - GO:0000741 - karyogamy - - - - - The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. - GOC:elh - - - - - - - - - - - - - - - - - - - - - - - - - - - The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. - cell fusion - biological_process - GO:0000768 - syncytium formation by plasma membrane fusion - - - - - The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. - GOC:mtg_muscle - GOC:tb - - - - - - - - - - - - - - - The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. - GO:0000789 - GO:0000790 - GO:0005717 - NIF_Subcellular:sao1615953555 - cytoplasmic chromatin - nuclear chromatin - cellular_component - chromosome scaffold - GO:0000785 - Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. - chromatin - - - - - The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. - GOC:elh - PMID:20404130 - - - - - - - - - A compact and highly condensed form of chromatin that is refractory to transcription. - https://github.com/geneontology/go-ontology/issues/22355 - GO:0005720 - GO:0035328 - NIF_Subcellular:sao581845896 - Wikipedia:Heterochromatin - transcriptionally inactive chromatin - transcriptionally silent chromatin - nuclear heterochromatin - cellular_component - GO:0000792 - heterochromatin - - - - - A compact and highly condensed form of chromatin that is refractory to transcription. - PMID:32017156 - - - - - - - - - - The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. - biological_process - GO:0000819 - sister chromatid segregation - - - - - The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. - GOC:ai - GOC:elh - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process in which the size or shape of a cell is generated and organized. - GO:0007148 - GO:0045790 - GO:0045791 - cellular morphogenesis - biological_process - GO:0000902 - - - - cell morphogenesis - - - - - The developmental process in which the size or shape of a cell is generated and organized. - GOC:clt - GOC:dph - GOC:go_curators - GOC:tb - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. - response to acid - biological_process - response to acid anion - response to oxoanion - GO:0001101 - - This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead. - response to acid chemical - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. - GOC:go_curators - GOC:rn - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). - skeletal development - biological_process - GO:0001501 - skeletal system development - - - - - The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). - GOC:dph - GOC:jid - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. - Wikipedia:Ossification - bone biosynthesis - bone formation - osteogenesis - biological_process - GO:0001503 - Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. - ossification - - - - - The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. - GOC:mtg_mpo - PMID:17572649 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. - - biological_process - GO:0001508 - Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so. - action potential - - - - - A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. - GOC:dph - GOC:go_curators - GOC:tb - ISBN:978-0-07-139011-8 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. - Wikipedia:Angiogenesis - blood vessel formation from pre-existing blood vessels - biological_process - GO:0001525 - angiogenesis - - - - - Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. - ISBN:0878932453 - - - - - blood vessel formation from pre-existing blood vessels - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. - biological_process - GO:0001555 - oocyte growth - - - - - The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. - https://www.ncbi.nlm.nih.gov/books/NBK279054/ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. - Wikipedia:Oocyte_maturation - biological_process - GO:0001556 - oocyte maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. - GOC:devbiol - https://www.ncbi.nlm.nih.gov/books/NBK279054/ - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, extent or direction of cell growth. - biological_process - GO:0001558 - regulation of cell growth - - - - - Any process that modulates the frequency, rate, extent or direction of cell growth. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. - biological_process - GO:0001568 - blood vessel development - - - - - The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. - GOC:hjd - UBERON:0001981 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. - patterning of blood vessels - biological_process - GO:0001569 - branching involved in blood vessel morphogenesis - - - - - The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. - GOC:dph - - - - - patterning of blood vessels - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. - Wikipedia:Vasculogenesis - vascular morphogenesis - biological_process - GO:0001570 - vasculogenesis - - - - - The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. - PMID:8999798 - - - - - - - - - - - - - - - - - - - - - A process that results in a parallel arrangement of microtubules. - microtubule bundling - biological_process - GO:0001578 - microtubule bundle formation - - - - - A process that results in a parallel arrangement of microtubules. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. - GO:0042460 - Wikipedia:Eye_development - biological_process - GO:0001654 - eye development - - - - - The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. - GOC:jid - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. - https://github.com/geneontology/go-ontology/issues/22178 - biological_process - GO:0001655 - urogenital system development - - - - - The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. - GOC:go_curators - - - - - - - - - A homeostatic process in which an organism modulates its internal body temperature. - Wikipedia:Thermoregulation - thermoregulation - biological_process - GO:0001659 - temperature homeostasis - - - - - A homeostatic process in which an organism modulates its internal body temperature. - GOC:jl - - - - - thermoregulation - GOC:dph - GOC:tb - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. - response to hypoxic stress - response to lowered oxygen tension - response to intermittent hypoxia - response to sustained hypoxia - biological_process - GO:0001666 - Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. - response to hypoxia - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. - GOC:hjd - - - - - - - - - Cell migration that is accomplished by extension and retraction of a pseudopodium. - ameboid cell migration - amoeboid cell migration - amoeboidal cell migration - biological_process - GO:0001667 - Note that this term refers to a mode of migration rather than to any particular cell type. - ameboidal-type cell migration - - - - - Cell migration that is accomplished by extension and retraction of a pseudopodium. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The nucleus of the female germ cell, a reproductive cell in females. - GO:0043080 - female germ-cell nucleus - cellular_component - GO:0001674 - female germ cell nucleus - - - - - The nucleus of the female germ cell, a reproductive cell in females. - CL:0000021 - GOC:hjd - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). - translation initiation ternary complex assembly - biological_process - GO:0001677 - formation of translation initiation ternary complex - - - - - Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). - GOC:hjd - - - - - - - - - - The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. - hydrochloric acid secretion - biological_process - GO:0001696 - gastric acid secretion - - - - - The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. - GOC:hjd - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster. - biological_process - GO:0001700 - embryonic development via the syncytial blastoderm - - - - - The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster. - GOC:go_curators - GOC:mtg_sensu - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. - biological_process - GO:0001701 - in utero embryonic development - - - - - The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. - GOC:go_curators - GOC:mtg_sensu - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The formation of the ectoderm, mesoderm and endoderm during gastrulation. - biological_process - GO:0001704 - formation of primary germ layer - - - - - The formation of the ectoderm, mesoderm and endoderm during gastrulation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The formation of ectoderm during gastrulation. - biological_process - GO:0001705 - ectoderm formation - - - - - The formation of ectoderm during gastrulation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The formation of the endoderm during gastrulation. - endoblast formation - biological_process - GO:0001706 - endoderm formation - - - - - The formation of the endoderm during gastrulation. - GOC:go_curators - - - - - endoblast formation - GOC:dph - GOC:sdb_2009 - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. - biological_process - GO:0001707 - mesoderm formation - - - - - The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The initial developmental process that will lead to the formation of an eye. - biological_process - optic placode formation - GO:0001743 - lens placode formation - - - - - The initial developmental process that will lead to the formation of an eye. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster. - insect-type retina morphogenesis - biological_process - GO:0001745 - compound eye morphogenesis - - - - - The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster. - GOC:dph - GOC:mtg_sensu - - - - - insect-type retina morphogenesis - PMID:11735386 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell. - biological_process - GO:0001751 - compound eye photoreceptor cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. - biological_process - GO:0001754 - eye photoreceptor cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. - Wikipedia:Somitogenesis - formation of mesodermal clusters - biological_process - GO:0001756 - somitogenesis - - - - - The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. - ISBN:0721662544 - - - - - formation of mesodermal clusters - - - - - - - - - - - The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. - branching morphogenesis - biological_process - GO:0001763 - morphogenesis of a branching structure - - - - - The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. - ISBN:0721662544 - - - - - branching morphogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. - immune cell homeostasis - leucocyte homeostasis - biological_process - GO:0001776 - Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. - leukocyte homeostasis - - - - - The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. - GOC:add - ISBN:0781735149 - - - - - - - - - - - - - - - - - - - - - - - - - - - The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. - 5-HT secretion - 5-hydroxytryptamine secretion - biological_process - serotonin release - GO:0001820 - serotonin secretion - - - - - The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. - GOC:ef - ISBN:0198506732 - ISBN:0781735149 - - - - - serotonin release - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. - biological_process - GO:0001824 - See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. - blastocyst development - - - - - The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. - GOC:dph - ISBN:0124020607 - ISBN:0198542771 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The initial formation of a blastocyst from a solid ball of cells known as a morula. - biological_process - GO:0001825 - See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. - blastocyst formation - - - - - The initial formation of a blastocyst from a solid ball of cells known as a morula. - GOC:dph - ISBN:0124020607 - ISBN:0198542771 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell. - biological_process - GO:0001826 - See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. - inner cell mass cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell. - GOC:dph - ISBN:0124020607 - ISBN:0198542771 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. - trophectoderm cell differentiation - biological_process - GO:0001829 - See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. - trophectodermal cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. - GOC:dph - ISBN:0124020607 - ISBN:0198542771 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The morphogenesis of trophectoderm cells. - trophectoderm cellular morphogenesis - biological_process - GO:0001831 - See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. - trophectodermal cellular morphogenesis - - - - - The morphogenesis of trophectoderm cells. - GOC:dph - ISBN:0124020607 - ISBN:0198542771 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. - biological_process - GO:0001832 - See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. - blastocyst growth - - - - - An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. - GOC:dph - ISBN:0124020607 - ISBN:0198542771 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The proliferation of cells in the inner cell mass. - biological_process - GO:0001833 - See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. - inner cell mass cell proliferation - - - - - The proliferation of cells in the inner cell mass. - GOC:dph - GOC:isa_complete - ISBN:0124020607 - ISBN:0198542771 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The proliferation of cells in the trophectoderm. - trophectoderm cell proliferation - biological_process - GO:0001834 - See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. - trophectodermal cell proliferation - - - - - The proliferation of cells in the trophectoderm. - GOC:dph - ISBN:0124020607 - ISBN:0198542771 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. - EMT - epithelial-mesenchymal transition - mesenchymal cell differentiation from epithelial cell - biological_process - GO:0001837 - epithelial to mesenchymal transition - - - - - A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. - GOC:dph - PMID:14701881 - - - - - mesenchymal cell differentiation from epithelial cell - GOC:BHF - GOC:dph - GOC:rl - - - - - - - - - - - - - - - The morphogenesis of an embryonic epithelium into a tube-shaped structure. - biological_process - GO:0001838 - embryonic epithelial tube formation - - - - - The morphogenesis of an embryonic epithelium into a tube-shaped structure. - GOC:dph - ISBN:0824072820 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue. - biological_process - GO:0001839 - neural plate morphogenesis - - - - - The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue. - GOC:dph - ISBN:0878932437 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. - biological_process - GO:0001840 - neural plate development - - - - - The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. - GOC:dph - GOC:ef - ISBN:0878932437 - ISBN:0878932585 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. - GO:0001679 - Wikipedia:Neurulation - neural tube morphogenesis - neurulation - biological_process - GO:0001841 - neural tube formation - - - - - The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. - GOC:dph - ISBN:0878932437 - - - - - neural tube morphogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove. - biological_process - neural groove formation - GO:0001842 - neural fold formation - - - - - The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove. - GOC:dph - ISBN:0878932437 - - - - - neural groove formation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. - biological_process - GO:0001878 - defined as response to Saccharomycotina (true yeasts). This excludes fission yeast. - response to yeast - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. - PMID:14707091 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of an endothelial cell over time, from its formation to the mature structure. - biological_process - GO:0001885 - endothelial cell development - - - - - The progression of an endothelial cell over time, from its formation to the mature structure. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell. - biological_process - GO:0001886 - endothelial cell morphogenesis - - - - - The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. - biological_process - GO:0001889 - liver development - - - - - The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. - GOC:add - ISBN:068340007X - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. - biological_process - GO:0001935 - endothelial cell proliferation - - - - - The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. - GOC:add - ISBN:0781735149 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. - biological_process - GO:0001936 - regulation of endothelial cell proliferation - - - - - Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. - down regulation of endothelial cell proliferation - down-regulation of endothelial cell proliferation - downregulation of endothelial cell proliferation - inhibition of endothelial cell proliferation - biological_process - GO:0001937 - negative regulation of endothelial cell proliferation - - - - - Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the rate or extent of endothelial cell proliferation. - up regulation of endothelial cell proliferation - up-regulation of endothelial cell proliferation - upregulation of endothelial cell proliferation - activation of endothelial cell proliferation - stimulation of endothelial cell proliferation - biological_process - GO:0001938 - positive regulation of endothelial cell proliferation - - - - - Any process that activates or increases the rate or extent of endothelial cell proliferation. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. - biological_process - vascular system development - GO:0001944 - vasculature development - - - - - The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. - GOC:dph - UBERON:0002409 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state. - biological_process - GO:0001955 - blood vessel maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. - up regulation of neurotransmitter secretion - up-regulation of neurotransmitter secretion - upregulation of neurotransmitter secretion - activation of neurotransmitter secretion - stimulation of neurotransmitter secretion - biological_process - GO:0001956 - positive regulation of neurotransmitter secretion - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. - GOC:hjd - - - - - - - - - Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells. - Wikipedia:Intramembranous_ossification - dermal ossification - biological_process - intramembranous bone ossification - GO:0001957 - An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. - intramembranous ossification - - - - - Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells. - ISBN:0878932437 - - - - - dermal ossification - GO_REF:0000034 - - - - - intramembranous bone ossification - GOC:cjm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. - epithelium morphogenesis - biological_process - GO:0002009 - morphogenesis of an epithelium - - - - - The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. - GOC:dph - GOC:jl - GOC:tb - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. - biological_process - GO:0002011 - morphogenesis of an epithelial sheet - - - - - The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. - GOC:jl - - - - - - - - - Any process that modulates the frequency or rate of heart contraction. - cardiac chronotropy - regulation of heart contraction rate - regulation of rate of heart contraction - biological_process - GO:0002027 - regulation of heart rate - - - - - Any process that modulates the frequency or rate of heart contraction. - GOC:dph - GOC:tb - PMID:10358008 - - - - - cardiac chronotropy - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - regulation of Na+ transport - regulation of sodium transport - biological_process - GO:0002028 - regulation of sodium ion transport - - - - - Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the rate of neuroblast proliferation. - up regulation of neuroblast proliferation - up-regulation of neuroblast proliferation - upregulation of neuroblast proliferation - activation of neuroblast proliferation - stimulation of neuroblast proliferation - biological_process - GO:0002052 - positive regulation of neuroblast proliferation - - - - - Any process that activates or increases the rate of neuroblast proliferation. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. - up regulation of mesenchymal cell proliferation - up-regulation of mesenchymal cell proliferation - upregulation of mesenchymal cell proliferation - activation of mesenchymal cell proliferation - stimulation of mesenchymal cell proliferation - biological_process - GO:0002053 - positive regulation of mesenchymal cell proliferation - - - - - The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. - biological_process - GO:0002062 - chondrocyte differentiation - - - - - The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. - biological_process - GO:0002063 - chondrocyte development - - - - - The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. - biological_process - GO:0002064 - epithelial cell development - - - - - The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. - biological_process - GO:0002065 - columnar/cuboidal epithelial cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. - biological_process - GO:0002066 - columnar/cuboidal epithelial cell development - - - - - The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. - biological_process - GO:0002067 - glandular epithelial cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. - biological_process - GO:0002068 - glandular epithelial cell development - - - - - The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. - biological_process - GO:0002069 - columnar/cuboidal epithelial cell maturation - - - - - The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. - biological_process - GO:0002070 - epithelial cell maturation - - - - - The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. - biological_process - GO:0002071 - glandular epithelial cell maturation - - - - - The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus. - optic cup morphogenesis involved in camera-style eye development - biological_process - GO:0002072 - optic cup morphogenesis involved in camera-type eye development - - - - - The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus. - GOC:dph - GOC:mtg_sensu - GOC:sdb_2009 - GOC:tb - ISBN:0878932437 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells. - negative regulation of neural plate formation - repression of premature neural plate formation - biological_process - GO:0002085 - inhibition of neuroepithelial cell differentiation - - - - - Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells. - GOC:dph - PMID:16678814 - - - - - negative regulation of neural plate formation - GOC:dph - GOC:tb - - - - - repression of premature neural plate formation - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. - neurological control of breathing - regulation of respiratory gaseous exchange by neurological system process - biological_process - GO:0002087 - regulation of respiratory gaseous exchange by nervous system process - - - - - A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. - GOC:dph - GOC:tb - PMID:12458206 - - - - - neurological control of breathing - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. - lens development - lens development in camera-style eye - biological_process - GO:0002088 - lens development in camera-type eye - - - - - The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. - GOC:dph - ISBN:0582064333 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. - lens morphogenesis - lens morphogenesis in camera-style eye - biological_process - GO:0002089 - lens morphogenesis in camera-type eye - - - - - The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. - GOC:dph - GOC:mtg_sensu - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. - biological_process - GO:0002119 - nematode larval development - - - - - The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. - GOC:ems - GOC:kmv - - - - - - - - - - The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters. - biological_process - GO:0002164 - larval development - - - - - The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters. - GOC:jid - ISBN:0877795088 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. - haematopoietic progenitor cell differentiation - haemopoietic progenitor cell differentiation - hemopoietic progenitor cell differentiation - biological_process - GO:0002244 - hematopoietic progenitor cell differentiation - - - - - The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. - GOC:add - GOC:rl - ISBN:0781735149 - PMID:16551251 - - - - - - - - - An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. - immune response in organ or tissue - biological_process - GO:0002251 - organ or tissue specific immune response - - - - - An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. - GOC:jal - GO_REF:0000022 - - - - - - - - - Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. - https://github.com/geneontology/go-ontology/issues/18737 - biological_process - GO:0002252 - immune effector process - - - - - Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. - GOC:add - GO_REF:0000022 - ISBN:0781735149 - - - - - - - - - - - - - - - - - - - - - - - - - - - The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. - biological_process - GO:0002262 - myeloid cell homeostasis - - - - - The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. - CL:0000763 - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages. - biological_process - GO:0002318 - myeloid progenitor cell differentiation - - - - - The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages. - GOC:add - PMID:16551264 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. - - Wikipedia:Immune_system - biological_process - GO:0002376 - - - - - - - Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). - immune system process - - - - - Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. - GOC:add - GO_REF:0000022 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An immune response taking place in the liver. - biological_process - GO:0002384 - hepatic immune response - - - - - An immune response taking place in the liver. - GOC:jal - GO_REF:0000022 - ISBN:0781735149 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process involved in the carrying out of an immune response by a leukocyte. - GO:0019723 - GO:0042087 - immune cell effector process - immune cell mediated immunity - leucocyte immune effector process - leucocyte mediated immunity - leukocyte immune effector process - biological_process - cell-mediated immune response - cellular immune response - GO:0002443 - leukocyte mediated immunity - - - - - Any process involved in the carrying out of an immune response by a leukocyte. - GOC:add - GO_REF:0000022 - ISBN:0781735149 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process involved in the carrying out of an immune response by a myeloid leukocyte. - myeloid leucocyte immune effector process - myeloid leucocyte mediated immunity - myeloid leukocyte immune effector process - biological_process - GO:0002444 - myeloid leukocyte mediated immunity - - - - - Any process involved in the carrying out of an immune response by a myeloid leukocyte. - GOC:add - GO_REF:0000022 - ISBN:0781735149 - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. - biological_process - GO:0002520 - - immune system development - - - - - The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. - GOC:add - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. - immune cell differentiation - leucocyte differentiation - biological_process - GO:0002521 - leukocyte differentiation - - - - - The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. - CL:0000738 - GOC:add - PMID:16551264 - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. - myeloid leucocyte differentiation - biological_process - GO:0002573 - myeloid leukocyte differentiation - - - - - The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. - GOC:add - PMID:16551251 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of an immune system process. - biological_process - GO:0002682 - regulation of immune system process - - - - - Any process that modulates the frequency, rate, or extent of an immune system process. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. - down regulation of immune system process - down-regulation of immune system process - downregulation of immune system process - inhibition of immune system process - biological_process - GO:0002683 - negative regulation of immune system process - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate, or extent of an immune system process. - up regulation of immune system process - up-regulation of immune system process - upregulation of immune system process - activation of immune system process - stimulation of immune system process - biological_process - GO:0002684 - positive regulation of immune system process - - - - - Any process that activates or increases the frequency, rate, or extent of an immune system process. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of an immune effector process. - biological_process - GO:0002697 - regulation of immune effector process - - - - - Any process that modulates the frequency, rate, or extent of an immune effector process. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. - down regulation of immune effector process - down-regulation of immune effector process - downregulation of immune effector process - inhibition of immune effector process - biological_process - GO:0002698 - negative regulation of immune effector process - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate, or extent of an immune effector process. - up regulation of immune effector process - up-regulation of immune effector process - upregulation of immune effector process - activation of immune effector process - stimulation of immune effector process - biological_process - GO:0002699 - positive regulation of immune effector process - - - - - Any process that activates or increases the frequency, rate, or extent of an immune effector process. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. - regulation of immune cell mediated immunity - regulation of leucocyte mediated immunity - biological_process - GO:0002703 - regulation of leukocyte mediated immunity - - - - - Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. - down regulation of leukocyte mediated immunity - down-regulation of leukocyte mediated immunity - downregulation of leukocyte mediated immunity - negative regulation of immune cell mediated immunity - negative regulation of leucocyte mediated immunity - inhibition of leukocyte mediated immunity - biological_process - GO:0002704 - negative regulation of leukocyte mediated immunity - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. - positive regulation of immune cell mediated immunity - positive regulation of leucocyte mediated immunity - up regulation of leukocyte mediated immunity - up-regulation of leukocyte mediated immunity - upregulation of leukocyte mediated immunity - activation of leukocyte mediated immunity - stimulation of leukocyte mediated immunity - biological_process - GO:0002705 - positive regulation of leukocyte mediated immunity - - - - - Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. - biological_process - GO:0002761 - regulation of myeloid leukocyte differentiation - - - - - Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. - down regulation of myeloid leukocyte differentiation - down-regulation of myeloid leukocyte differentiation - downregulation of myeloid leukocyte differentiation - inhibition of myeloid leukocyte differentiation - biological_process - GO:0002762 - negative regulation of myeloid leukocyte differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. - up regulation of myeloid leukocyte differentiation - up-regulation of myeloid leukocyte differentiation - upregulation of myeloid leukocyte differentiation - activation of myeloid leukocyte differentiation - stimulation of myeloid leukocyte differentiation - biological_process - GO:0002763 - positive regulation of myeloid leukocyte differentiation - - - - - Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - The controlled release of a peptide from a cell or a tissue. - biological_process - GO:0002790 - peptide secretion - - - - - The controlled release of a peptide from a cell or a tissue. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of peptide secretion. - biological_process - GO:0002791 - regulation of peptide secretion - - - - - Any process that modulates the frequency, rate, or extent of peptide secretion. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. - down regulation of peptide secretion - down-regulation of peptide secretion - downregulation of peptide secretion - inhibition of peptide secretion - biological_process - GO:0002792 - negative regulation of peptide secretion - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate, or extent of peptide secretion. - up regulation of peptide secretion - up-regulation of peptide secretion - upregulation of peptide secretion - activation of peptide secretion - stimulation of peptide secretion - biological_process - GO:0002793 - positive regulation of peptide secretion - - - - - Any process that activates or increases the frequency, rate, or extent of peptide secretion. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. - biological_process - GO:0002831 - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - regulation of response to biotic stimulus - - - - - Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. - down regulation of response to biotic stimulus - down-regulation of response to biotic stimulus - downregulation of response to biotic stimulus - inhibition of response to biotic stimulus - biological_process - GO:0002832 - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - negative regulation of response to biotic stimulus - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. - up regulation of response to biotic stimulus - up-regulation of response to biotic stimulus - upregulation of response to biotic stimulus - activation of response to biotic stimulus - stimulation of response to biotic stimulus - biological_process - GO:0002833 - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - positive regulation of response to biotic stimulus - - - - - Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity. - biological_process - GO:0002886 - regulation of myeloid leukocyte mediated immunity - - - - - Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity. - down regulation of myeloid leukocyte mediated immunity - down-regulation of myeloid leukocyte mediated immunity - downregulation of myeloid leukocyte mediated immunity - inhibition of myeloid leukocyte mediated immunity - biological_process - GO:0002887 - negative regulation of myeloid leukocyte mediated immunity - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. - up regulation of myeloid leukocyte mediated immunity - up-regulation of myeloid leukocyte mediated immunity - upregulation of myeloid leukocyte mediated immunity - activation of myeloid leukocyte mediated immunity - stimulation of myeloid leukocyte mediated immunity - biological_process - GO:0002888 - positive regulation of myeloid leukocyte mediated immunity - - - - - Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move. - hjd - 2012-04-23T02:11:22Z - biological_process - GO:0002932 - tendon sheath development - - - - - The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move. - PMID:20696843 - - - - - - - - - The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. - biological_process - pattern formation - GO:0003002 - regionalization - - - - - The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. - GOC:dph - GOC:isa_complete - - - - - pattern formation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. - puberty - biological_process - reproductive developmental process - GO:0003006 - developmental process involved in reproduction - - - - - A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. - GOC:dph - GOC:isa_complete - - - - - puberty - GOC:dph - - - - - reproductive developmental process - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. - biological_process - cardiac morphogenesis - GO:0003007 - heart morphogenesis - - - - - The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. - GOC:dph - GOC:isa_complete - - - - - - - - - A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. - organ system process - biological_process - GO:0003008 - system process - - - - - A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. - GOC:mtg_cardio - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. - biological_process - GO:0003009 - skeletal muscle contraction - - - - - A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. - GOC:mtg_cardio - GOC:mtg_muscle - - - - - - - - - A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. - biological_process - muscle physiological process - GO:0003012 - - - muscle system process - - - - - A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. - GOC:mtg_cardio - - - - - - - - - A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. - Wikipedia:Circulatory_system - biological_process - GO:0003013 - - - circulatory system process - - - - - A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. - GOC:mtg_cardio - - - - - - - - - A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). - excretory system process - biological_process - kidney system process - GO:0003014 - - renal system process - - - - - A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). - GOC:cjm - GOC:mtg_cardio - GOC:mtg_kidney_jan10 - - - - - - - - - A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. - biological_process - cardiac process - GO:0003015 - heart process - - - - - A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. - GOC:mtg_cardio - - - - - - - - - - - - - - - A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. - GO:0010802 - respiratory gaseous exchange - biological_process - GO:0003016 - - respiratory system process - - - - - A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. - GOC:dph - GOC:mtg_cardio - GOC:tb - - - - - - - - - - The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal. - biological_process - GO:0003032 - detection of oxygen - - - - - The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal. - GOC:mtg_cardio - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of sodium ions (Na+) by the renal system. - biological_process - GO:0003096 - renal sodium ion transport - - - - - The directed movement of sodium ions (Na+) by the renal system. - GOC:mtg_cardio - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that mediates the transfer of information from endodermal cells to mesodermal cells. - tb - 2009-09-22T03:10:29Z - endodermal-mesodermal cell signalling - biological_process - GO:0003133 - endodermal-mesodermal cell signaling - - - - - Any process that mediates the transfer of information from endodermal cells to mesodermal cells. - GOC:mtg_heart - - - - - endodermal-mesodermal cell signalling - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field. - tb - 2009-09-22T04:12:18Z - cardiac crescent morphogenesis - biological_process - GO:0003142 - cardiogenic plate morphogenesis - - - - - The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field. - GOC:mtg_heart - - - - - cardiac crescent morphogenesis - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. - tb - 2009-09-22T04:21:17Z - biological_process - GO:0003143 - embryonic heart tube morphogenesis - - - - - The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. - tb - 2009-09-22T04:22:34Z - biological_process - GO:0003144 - embryonic heart tube formation - - - - - The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. - GOC:mtg_heart - - - - - - - - - The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis. - tb - 2009-09-22T04:26:03Z - biological_process - GO:0003145 - embryonic heart tube formation via epithelial folding - - - - - The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. - tb - 2009-09-22T07:51:01Z - biological_process - GO:0003148 - outflow tract septum morphogenesis - - - - - The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum. - tb - 2009-09-22T07:51:41Z - biological_process - GO:0003149 - membranous septum morphogenesis - - - - - The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum. - tb - 2009-09-22T07:53:28Z - biological_process - GO:0003150 - muscular septum morphogenesis - - - - - The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. - tb - 2009-09-22T07:59:24Z - biological_process - GO:0003151 - outflow tract morphogenesis - - - - - The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. - GOC:mtg_heart - UBERON:0004145 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation. - tb - 2009-09-23T10:10:24Z - biological_process - GO:0003152 - morphogenesis of an epithelial fold involved in embryonic heart tube formation - - - - - The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. - tb - 2009-09-30T11:21:09Z - biological_process - GO:0003156 - regulation of animal organ formation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. - GOC:dph - GOC:mtg_heart - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. - dph - 2009-10-01T12:42:27Z - biological_process - GO:0003157 - endocardium development - - - - - The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. - dph - 2009-10-01T12:50:57Z - biological_process - GO:0003158 - endothelium development - - - - - The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. - dph - 2009-10-01T01:34:06Z - biological_process - GO:0003159 - morphogenesis of an endothelium - - - - - The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. - dph - 2009-10-01T01:37:26Z - biological_process - GO:0003160 - endocardium morphogenesis - - - - - The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. - dph - 2009-10-01T01:57:16Z - cardiac impulse conducting system development - heart conduction system development - biological_process - GO:0003161 - cardiac conduction system development - - - - - The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. - GOC:mtg_heart - - - - - cardiac impulse conducting system development - GOC:mtg_heart - - - - - heart conduction system development - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system. - dph - 2009-10-01T02:05:13Z - AV node development - biological_process - GO:0003162 - atrioventricular node development - - - - - The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system. - GOC:mtg_heart - - - - - AV node development - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node. - dph - 2009-10-01T02:06:09Z - SA node development - SAN development - sinus node development - biological_process - GO:0003163 - sinoatrial node development - - - - - The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node. - GOC:mtg_heart - - - - - SA node development - GOC:mtg_heart - - - - - SAN development - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - sinus node development - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. - dph - 2009-10-01T02:07:12Z - biological_process - GO:0003164 - His-Purkinje system development - - - - - The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. - dph - 2009-10-01T02:07:50Z - cardiac Purkinje fiber development - biological_process - GO:0003165 - Purkinje myocyte development - - - - - The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. - GOC:mtg_cardiac_conduct_nov11 - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle. - dph - 2009-10-01T02:49:54Z - cardiac Purkinje fiber cell differentiation - biological_process - GO:0003168 - Purkinje myocyte differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle. - GOC:mtg_cardiac_conduct_nov11 - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of veins of the heart are generated and organized. - dph - 2009-10-08T10:45:41Z - biological_process - GO:0003169 - coronary vein morphogenesis - - - - - The process in which the anatomical structures of veins of the heart are generated and organized. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. - dph - 2009-10-08T01:17:43Z - biological_process - GO:0003197 - endocardial cushion development - - - - - The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. - dph - 2009-10-08T01:43:22Z - biological_process - GO:0003203 - endocardial cushion morphogenesis - - - - - The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart. - dph - 2009-10-13T09:05:04Z - heart fibrous skeleton development - biological_process - GO:0003204 - cardiac skeleton development - - - - - The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart. - GOC:mtg_heart - - - - - heart fibrous skeleton development - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. - dph - 2009-10-13T09:11:18Z - biological_process - GO:0003205 - cardiac chamber development - - - - - The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. - dph - 2009-10-13T09:14:51Z - heart chamber morphogenesis - biological_process - GO:0003206 - cardiac chamber morphogenesis - - - - - The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. - GOC:mtg_heart - - - - - heart chamber morphogenesis - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. - dph - 2009-10-13T09:29:13Z - heart chamber formation - biological_process - GO:0003207 - cardiac chamber formation - - - - - The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. - GOC:mtg_heart - - - - - heart chamber formation - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. - dph - 2009-10-13T09:38:44Z - biological_process - GO:0003208 - cardiac ventricle morphogenesis - - - - - The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. - dph - 2009-10-13T09:39:44Z - biological_process - GO:0003209 - cardiac atrium morphogenesis - - - - - The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. - dph - 2009-10-13T09:44:25Z - biological_process - GO:0003210 - cardiac atrium formation - - - - - The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. - dph - 2009-10-13T09:46:27Z - biological_process - GO:0003211 - cardiac ventricle formation - - - - - The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the left cardiac atrium is generated and organized. - dph - 2009-10-13T09:48:16Z - biological_process - GO:0003212 - cardiac left atrium morphogenesis - - - - - The process in which the left cardiac atrium is generated and organized. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the right cardiac atrium is generated and organized. - dph - 2009-10-13T09:49:03Z - biological_process - GO:0003213 - cardiac right atrium morphogenesis - - - - - The process in which the right cardiac atrium is generated and organized. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the left cardiac ventricle is generated and organized. - dph - 2009-10-13T09:50:08Z - biological_process - GO:0003214 - cardiac left ventricle morphogenesis - - - - - The process in which the left cardiac ventricle is generated and organized. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the right cardiac ventricle is generated and organized. - dph - 2009-10-13T09:50:57Z - biological_process - GO:0003215 - cardiac right ventricle morphogenesis - - - - - The process in which the right cardiac ventricle is generated and organized. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts. - dph - 2009-10-13T09:52:31Z - biological_process - GO:0003216 - cardiac left atrium formation - - - - - The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts. - dph - 2009-10-13T09:53:12Z - biological_process - GO:0003217 - cardiac right atrium formation - - - - - The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts. - dph - 2009-10-13T09:54:33Z - biological_process - GO:0003218 - cardiac left ventricle formation - - - - - The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts. - dph - 2009-10-13T09:55:38Z - biological_process - GO:0003219 - cardiac right ventricle formation - - - - - The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized. - dph - 2009-10-13T10:18:05Z - left ventricular myocardium morphogenesis - biological_process - GO:0003220 - left ventricular cardiac muscle tissue morphogenesis - - - - - The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized. - GOC:mtg_heart - - - - - left ventricular myocardium morphogenesis - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized. - dph - 2009-10-13T10:26:33Z - right ventricle myocardium morphogenesis - biological_process - GO:0003221 - right ventricular cardiac muscle tissue morphogenesis - - - - - The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized. - GOC:mtg_heart - - - - - right ventricle myocardium morphogenesis - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. - dph - 2009-10-13T10:33:00Z - biological_process - trabecula carnea morphogenesis - GO:0003222 - ventricular trabecula myocardium morphogenesis - - - - - The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. - GOC:mtg_heart - - - - - trabecula carnea morphogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized. - dph - 2009-10-13T10:45:09Z - biological_process - GO:0003225 - left ventricular trabecular myocardium morphogenesis - - - - - The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the right ventricular myocardium are generated and organized. - dph - 2009-10-13T10:50:59Z - biological_process - GO:0003227 - right ventricular trabecular myocardium morphogenesis - - - - - The process in which the anatomical structures of the right ventricular myocardium are generated and organized. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure. - https://github.com/geneontology/go-ontology/issues/22614 - dph - 2009-10-13T10:53:18Z - atrial myocardium development - biological_process - GO:0003228 - atrial cardiac muscle tissue development - - - - - The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure. - GOC:mtg_heart - - - - - atrial myocardium development - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. - dph - 2009-10-13T10:56:01Z - ventricular myocardium development - biological_process - GO:0003229 - ventricular cardiac muscle tissue development - - - - - The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. - GOC:mtg_heart - - - - - ventricular myocardium development - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. - dph - 2009-10-13T11:02:07Z - biological_process - GO:0003230 - cardiac atrium development - - - - - The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. - dph - 2009-10-13T11:03:16Z - biological_process - GO:0003231 - cardiac ventricle development - - - - - The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. - dph - 2009-10-13T11:12:34Z - biological_process - GO:0003235 - sinus venosus development - - - - - The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. - dph - 2009-10-13T11:16:52Z - biological_process - GO:0003236 - sinus venosus morphogenesis - - - - - The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. - dph - 2009-10-13T11:18:34Z - biological_process - GO:0003237 - sinus venosus formation - - - - - The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Developmental growth that contributes to the shaping of the heart. - dph - 2009-10-13T11:28:46Z - biological_process - GO:0003241 - growth involved in heart morphogenesis - - - - - Developmental growth that contributes to the shaping of the heart. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart. - dph - 2009-10-13T11:44:21Z - biological_process - GO:0003245 - cardiac muscle tissue growth involved in heart morphogenesis - - - - - The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle. - dph - 2009-10-13T11:53:12Z - biological_process - GO:0003248 - heart capillary growth - - - - - The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. - dph - 2009-10-20T08:53:19Z - biological_process - GO:0003272 - endocardial cushion formation - - - - - The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. - GOC:mtg_heart - PMID:15797462 - - - - - - - - - - - - - - - - - - - - - - - - - - The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. - dph - 2009-10-20T09:08:44Z - biological_process - GO:0003273 - cell migration involved in endocardial cushion formation - - - - - The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries. - dph - 2009-10-20T09:30:01Z - apoptosis involved in outflow tract morphogenesis - biological_process - GO:0003275 - apoptotic process involved in outflow tract morphogenesis - - - - - Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries. - GOC:mtg_apoptosis - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. - dph - 2009-10-20T09:37:03Z - apoptosis involved in endocardial cushion morphogenesis - biological_process - GO:0003277 - apoptotic process involved in endocardial cushion morphogenesis - - - - - Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. - GOC:mtg_apoptosis - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process that contributes to the shaping of the heart. - dph - 2009-10-20T09:40:22Z - apoptosis involved in heart morphogenesis - biological_process - GO:0003278 - apoptotic process involved in heart morphogenesis - - - - - Any apoptotic process that contributes to the shaping of the heart. - GOC:mtg_apoptosis - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of a cardiac septum over time, from its initial formation to the mature structure. - dph - 2009-10-20T09:45:13Z - heart septum development - biological_process - GO:0003279 - cardiac septum development - - - - - The progression of a cardiac septum over time, from its initial formation to the mature structure. - GOC:mtg_heart - - - - - heart septum development - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the ventricular septum over time from its formation to the mature structure. - dph - 2009-10-20T10:04:51Z - interventricular septum development - septum inferius development - biological_process - GO:0003281 - ventricular septum development - - - - - The progression of the ventricular septum over time from its formation to the mature structure. - GOC:mtg_heart - - - - - interventricular septum development - GOC:mtg_heart - - - - - septum inferius development - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the atrial septum over time, from its initial formation to the mature structure. - dph - 2009-10-20T10:10:38Z - biological_process - GO:0003283 - atrial septum development - - - - - The progression of the atrial septum over time, from its initial formation to the mature structure. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which an endocardial cushion cell becomes a cell of a cardiac septum. - dph - 2009-10-20T11:03:46Z - biological_process - GO:0003292 - cardiac septum cell differentiation - - - - - The process in which an endocardial cushion cell becomes a cell of a cardiac septum. - GOC:mtg_heart - - - - - - - - - The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development. - dph - 2009-10-22T09:24:51Z - biological_process - GO:0003298 - physiological muscle hypertrophy - - - - - The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development. - GOC:mtg_heart - - - - - - - - - The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. - dph - 2009-10-22T10:33:56Z - biological_process - GO:0003300 - cardiac muscle hypertrophy - - - - - The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. - GOC:mtg_heart - - - - - - - - - - - - - - - - The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart. - dph - 2009-10-22T10:38:10Z - biological_process - GO:0003301 - physiological cardiac muscle hypertrophy - - - - - The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. - dph - 2009-10-26T09:27:23Z - pancreatic B cell differentiation - pancreatic beta cell differentiation - biological_process - GO:0003309 - type B pancreatic cell differentiation - - - - - The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. - CL:0000169 - GOC:dph - PMID:11076772 - - - - - pancreatic B cell differentiation - GOC:mah - - - - - pancreatic beta cell differentiation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon. - dph - 2009-10-26T09:28:05Z - pancreatic alpha cell differentiation - biological_process - GO:0003310 - pancreatic A cell differentiation - - - - - The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon. - GOC:dph - PMID:11076772 - - - - - pancreatic alpha cell differentiation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin. - dph - 2009-10-26T09:30:27Z - pancreatic delta cell differentiation - biological_process - GO:0003311 - pancreatic D cell differentiation - - - - - The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin. - GOC:dph - PMID:11076772 - - - - - pancreatic delta cell differentiation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. - dph - 2009-10-26T09:32:32Z - pancreatic polypeptide-producing cell differentiation - biological_process - GO:0003312 - pancreatic PP cell differentiation - - - - - The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. - GOC:dph - PMID:11076772 - - - - - pancreatic polypeptide-producing cell differentiation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. - dph - 2009-10-27T08:32:40Z - heart cone development - biological_process - GO:0003313 - heart rudiment development - - - - - The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. - GOC:mtg_heart - - - - - heart cone development - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the heart rudiment are generated and organized. - dph - 2009-10-27T08:38:04Z - heart cone morphogenesis - biological_process - GO:0003314 - heart rudiment morphogenesis - - - - - The process in which the anatomical structures of the heart rudiment are generated and organized. - GOC:mtg_heart - - - - - heart cone morphogenesis - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of the heart rudiment. - dph - 2009-10-27T08:43:37Z - heart cone formation - biological_process - GO:0003315 - heart rudiment formation - - - - - The developmental process pertaining to the initial formation of the heart rudiment. - GOC:mtg_heart - - - - - heart cone formation - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon. - dph - 2009-11-02T08:13:55Z - pancreatic alpha cell development - biological_process - GO:0003322 - pancreatic A cell development - - - - - The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon. - GOC:dph - - - - - pancreatic alpha cell development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. - dph - 2009-11-02T08:20:11Z - pancreatic B cell development - pancreatic beta cell development - biological_process - GO:0003323 - type B pancreatic cell development - - - - - The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. - CL:0000169 - GOC:dph - - - - - pancreatic B cell development - GOC:mah - - - - - pancreatic beta cell development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin. - dph - 2009-11-02T08:23:26Z - pancreatic delta cell development - biological_process - GO:0003324 - pancreatic D cell development - - - - - The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin. - GOC:dph - - - - - pancreatic delta cell development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. - dph - 2009-11-02T08:25:03Z - biological_process - GO:0003325 - pancreatic PP cell development - - - - - The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which an amino acid is transported across a membrane. - dph - 2009-11-02T02:36:11Z - amino acid membrane transport - biological_process - GO:0003333 - Note that this term is not intended for use in annotating lateral movement within membranes. - amino acid transmembrane transport - - - - - The process in which an amino acid is transported across a membrane. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum. - dph - 2009-12-01T10:30:17Z - biological_process - GO:0003342 - proepicardium development - - - - - The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum. - GOC:dph - PMID:18722343 - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme. - dph - 2009-12-01T10:40:17Z - biological_process - GO:0003343 - septum transversum development - - - - - The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme. - GOC:dph - PMID:18722343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of the pericardium is generated and organized. - dph - 2009-12-01T10:46:34Z - biological_process - GO:0003344 - pericardium morphogenesis - - - - - The process in which the anatomical structure of the pericardium is generated and organized. - GOC:dph - PMID:18722343 - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell. - dph - 2009-12-01T11:12:05Z - biological_process - GO:0003348 - cardiac endothelial cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell. - GOC:dph - PMID:18722343 - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline. - dph - 2009-12-03T10:34:30Z - norepinephrine secreting neuron differentiation - biological_process - GO:0003357 - noradrenergic neuron differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline. - GOC:dph - - - - - norepinephrine secreting neuron differentiation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. - dph - 2009-12-03T10:38:37Z - norepinephrine secreting neuron development - biological_process - GO:0003358 - noradrenergic neuron development - - - - - The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. - GOC:dph - - - - - norepinephrine secreting neuron development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord. - dph - 2009-12-03T10:47:20Z - biological_process - GO:0003360 - brainstem development - - - - - The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem. - dph - 2009-12-03T10:53:30Z - biological_process - GO:0003361 - noradrenergic neuron differentiation involved in brainstem development - - - - - The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell. - - dph - 2009-12-08T04:50:41Z - biological_process - GO:0003365 - establishment of cell polarity involved in ameboidal cell migration - - - - - The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell. - dph - 2009-12-08T05:42:46Z - biological_process - GO:0003371 - establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration - - - - - Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation. - dph - 2009-12-09T06:54:44Z - biological_process - GO:0003379 - establishment of cell polarity involved in gastrulation cell migration - - - - - The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation. - dph - 2009-12-09T07:10:57Z - biological_process - GO:0003380 - establishment or maintenance of cytoskeleton polarity involved in gastrulation - - - - - Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation. - dph - 2009-12-09T07:18:53Z - biological_process - GO:0003381 - epithelial cell morphogenesis involved in gastrulation - - - - - The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. - dph - 2009-12-09T07:21:06Z - biological_process - GO:0003382 - epithelial cell morphogenesis - - - - - The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. - dph - 2009-12-21T01:42:37Z - biological_process - GO:0003403 - optic vesicle formation - - - - - The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. - dph - 2009-12-21T01:54:34Z - biological_process - GO:0003404 - optic vesicle morphogenesis - - - - - The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. - dph - 2009-12-21T02:15:14Z - biological_process - GO:0003407 - neural retina development - - - - - The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye. - dph - 2009-12-21T03:04:27Z - biological_process - GO:0003411 - cell motility involved in camera-type eye morphogenesis - - - - - Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. - dph - 2009-12-22T08:39:58Z - biological_process - GO:0003413 - chondrocyte differentiation involved in endochondral bone morphogenesis - - - - - The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized. - dph - 2009-12-22T08:42:55Z - biological_process - GO:0003414 - chondrocyte morphogenesis involved in endochondral bone morphogenesis - - - - - The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The increase in size or mass of an endochondral bone that contributes to the shaping of the bone. - dph - 2009-12-22T08:52:55Z - biological_process - GO:0003416 - endochondral bone growth - - - - - The increase in size or mass of an endochondral bone that contributes to the shaping of the bone. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone. - dph - 2009-12-22T12:42:44Z - biological_process - GO:0003433 - chondrocyte development involved in endochondral bone morphogenesis - - - - - The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. - GO:0005554 - molecular function - molecular_function - GO:0003674 - - - - - - - Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. - molecular_function - - - - - A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. - GOC:pdt - - - - - - - - - Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. - Wikipedia:Enzyme - enzyme activity - molecular_function - GO:0003824 - - - - - - - - catalytic activity - - - - - Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. - GOC:vw - ISBN:0198506732 - - - - - enzyme activity - GOC:dph - GOC:tb - - - - - - - - - Catalysis of the hydrolysis of ester linkages within nucleic acids. - molecular_function - GO:0004518 - - - - - Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', and 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906' do not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. - nuclease activity - - - - - Catalysis of the hydrolysis of ester linkages within nucleic acids. - ISBN:0198547684 - - - - - - - - - - - - - - - - Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. - GO:0004537 - Reactome:R-HSA-211247 - Reactome:R-HSA-5685994 - Reactome:R-HSA-6785986 - deoxyribonuclease activity - caspase-activated deoxyribonuclease activity - molecular_function - GO:0004536 - DNA nuclease activity - - - - - Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. - GOC:mah - ISBN:0198547684 - - - - - Reactome:R-HSA-211247 - Cleavage of DNA by DFF40 - - - - - Reactome:R-HSA-5685994 - Long-range resection of DNA DSBs by EXO1 or DNA2 - - - - - Reactome:R-HSA-6785986 - DNA nucleases unhook the interstrand crosslink (ICL) - - - - - - - - - Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. - GO:0005478 - molecular_function - carrier - GO:0005215 - - - - - - - - - - - - Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. - transporter activity - - - - - Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. - GOC:ai - GOC:dgf - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. - GO:0005279 - amine/amide/polyamine channel activity - amine/polyamine transmembrane transporter activity - amino acid-polyamine transmembrane transporter activity - molecular_function - GO:0005275 - amine transmembrane transporter activity - - - - - Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. - GOC:mtg_transport - ISBN:0198506732 - ISBN:0815340729 - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. - Reactome:R-HSA-264615 - molecular_function - GO:0005277 - acetylcholine transmembrane transporter activity - - - - - Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. - GOC:ai - - - - - Reactome:R-HSA-264615 - Loading of acetylcholine in synaptic vesicles - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. - GO:0005312 - GO:0015365 - Reactome:R-HSA-1614546 - Reactome:R-HSA-372843 - dicarboxylate carrier - sodium:dicarboxylate/tricarboxylate symporter activity - molecular_function - dicarboxylate (succinate/fumarate/malate) antiporter activity - dicarboxylic acid permease activity - GO:0005310 - dicarboxylic acid transmembrane transporter activity - - - - - Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. - GOC:ai - - - - - Reactome:R-HSA-1614546 - Sulfate is exported to the cytosol in exchange for dicarboxylate - - - - - Reactome:R-HSA-372843 - SLC25A10 mediates exchange of malate and phosphate - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the directed movement of lipids into, out of or within a cell, or between cells. - Reactome:R-HSA-1369028 - Reactome:R-HSA-1369052 - Reactome:R-HSA-174786 - Reactome:R-HSA-5682285 - Reactome:R-HSA-5682311 - Reactome:R-HSA-5683672 - Reactome:R-HSA-5683714 - Reactome:R-HSA-5688397 - Reactome:R-HSA-6801250 - Reactome:R-HSA-8848053 - Reactome:R-HSA-8866329 - lipophorin - molecular_function - apolipoprotein - GO:0005319 - lipid transporter activity - - - - - - - - - - - GO_REF:0000090 - - - - - Enables the directed movement of lipids into, out of or within a cell, or between cells. - GOC:ai - - - - - Reactome:R-HSA-1369028 - ABCAs mediate lipid efflux - - - - - Reactome:R-HSA-1369052 - ABCAs mediate lipid influx - - - - - Reactome:R-HSA-174786 - ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex - - - - - Reactome:R-HSA-5682285 - ABCA12 transports lipids from cytosol to extracellular region - - - - - Reactome:R-HSA-5682311 - Defective ABCA12 does not transport lipids from cytosol to extracellular region - - - - - Reactome:R-HSA-5683672 - Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body - - - - - Reactome:R-HSA-5683714 - ABCA3 transports PC, PG from ER membrane to lamellar body - - - - - Reactome:R-HSA-5688397 - Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body - - - - - Reactome:R-HSA-6801250 - TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane - - - - - Reactome:R-HSA-8848053 - ABCA5 transports CHOL from lysosomal lumen to cytosol - - - - - Reactome:R-HSA-8866329 - MTTP lipidates APOB-100, forming a pre-VLDL - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. - Reactome:R-HSA-374896 - Reactome:R-HSA-374919 - molecular_function - neurotransmitter transporter activity - GO:0005326 - neurotransmitter transmembrane transporter activity - - - - - - - - - - - GO_REF:0000090 - - - - - Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. - GOC:ai - ISBN:0198506732 - - - - - Reactome:R-HSA-374896 - Uptake of Noradrenaline - - - - - Reactome:R-HSA-374919 - Noradrenaline clearance from the synaptic cleft - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage. - molecular_function - GO:0005342 - organic acid transmembrane transporter activity - - - - - Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. - GO:0015579 - Reactome:R-HSA-499981 - Reactome:R-HSA-5653873 - glucose permease activity - lactose/glucose efflux transporter activity - molecular_function - galactose/glucose (methylgalactoside) porter activity - GO:0005355 - glucose transmembrane transporter activity - - - - - Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. - GOC:ai - GOC:mtg_transport - ISBN:0815340729 - - - - - Reactome:R-HSA-499981 - Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 - - - - - Reactome:R-HSA-5653873 - SLC2A1 tetramer transports Glc from cytosol to Golgi lumen - - - - - - - - - - A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome). - GO:0008372 - NIF_Subcellular:sao1337158144 - cell or subcellular entity - cellular component - cellular_component - subcellular entity - GO:0005575 - - - - - - - Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. - cellular_component - - - - - A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome). - GOC:pdt - NIF_Subcellular:sao1337158144 - - - - - subcellular entity - NIF_Subcellular:nlx_subcell_100315 - - - - - - - - - The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. - Wikipedia:Extracellular - extracellular - cellular_component - GO:0005576 - - - - - - - - - - - - Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. - extracellular region - - - - - The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. - fibrinogen - fibrinogen alpha chain - fibrinogen beta chain - fibrinogen gamma chain - cellular_component - GO:0005577 - fibrinogen complex - - - - - A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. - ISBN:0198547684 - - - - - - - - - - - - - - - - - - - - - A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. - Wikipedia:Collagen - cellular_component - GO:0005581 - collagen trimer - - - - - - - - - - - PMID:12382326 - - - - - - - - - - - PMID:12382326 - - - - - A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. - GOC:dos - GOC:mah - ISBN:0721639976 - PMID:19693541 - PMID:21421911 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any triple helical collagen trimer that forms fibrils. - cellular_component - GO:0005583 - fibrillar collagen trimer - - - - - Any triple helical collagen trimer that forms fibrils. - GOC:mah - ISBN:0721639976 - PMID:21421911 - - - - - - - - - - - - - - - - - - - - - - A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes. - Wikipedia:Collagen_type_IV - cellular_component - GO:0005587 - collagen type IV trimer - - - - - A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes. - ISBN:0721639976 - PMID:19693541 - PMID:21421911 - - - - - - - - - A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. - GO:0005605 - GO:0008003 - Wikipedia:Basement_membrane - cellular_component - basal lamina - basement lamina - lamina densa - GO:0005604 - Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer. - basement membrane - - - - - A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. - ISBN:0198547684 - PMID:22505934 - - - - - - - - - - - - - - - That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. - NIF_Subcellular:sao1425028079 - cellular_component - intercellular space - GO:0005615 - - - - - Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. - extracellular space - - - - - That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. - ISBN:0198547684 - - - - - - - - - - - - - - - A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. - https://github.com/geneontology/go-ontology/issues/17776 - Wikipedia:Intracellular - internal to cell - intracellular - protoplasm - cellular_component - nucleocytoplasm - protoplast - GO:0005622 - - - - - intracellular anatomical structure - - - - - A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. - ISBN:0198506732 - - - - - nucleocytoplasm - GOC:mah - - - - - protoplast - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. - NIF_Subcellular:sao1702920020 - Wikipedia:Cell_nucleus - cell nucleus - horsetail nucleus - cellular_component - GO:0005634 - - - - - - - - - - - - nucleus - - - - - A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. - GOC:go_curators - - - - - horsetail nucleus - GOC:al - GOC:mah - GOC:vw - PMID:15030757 - - - - - - - - - - - - - - - - - - - - - The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). - GO:0005636 - Wikipedia:Nuclear_envelope - cellular_component - GO:0005635 - - - - nuclear envelope - - - - - The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). - ISBN:0198547684 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. - NIF_Subcellular:sao1617136075 - nucleus outer envelope - perinuclear membrane - cellular_component - GO:0005640 - nuclear outer membrane - - - - - The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. - ISBN:0198547684 - - - - - - - - - - - - - - - A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. - Wikipedia:Chromosome - interphase chromosome - prophase chromosome - cellular_component - chromatid - GO:0005694 - - - - - - - - - - - Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. - chromosome - - - - - A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. - ISBN:0198547684 - - - - - - - - - - - - - - - - - - - - - A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. - NIF_Subcellular:sao1820400233 - Wikipedia:Nucleolus - cellular_component - GO:0005730 - - - - - - - - nucleolus - - - - - A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. - ISBN:0198506732 - - - - - - - - - - - - - - - The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. - https://github.com/geneontology/go-ontology/issues/23023 - Wikipedia:Cytoplasm - cellular_component - GO:0005737 - - - - - - - - cytoplasm - - - - - The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. - ISBN:0198547684 - - - - - - - - - - - - - - - A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. - Wikipedia:Vacuole - cellular_component - vacuolar carboxypeptidase Y - GO:0005773 - - - - - - - - - - - vacuole - - - - - A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. - GOC:mtg_sensu - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. - cellular_component - GO:0005774 - vacuolar membrane - - - - - The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The volume enclosed within the vacuolar membrane. - cellular_component - GO:0005775 - vacuolar lumen - - - - - The volume enclosed within the vacuolar membrane. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. - Golgi - NIF_Subcellular:sao451912436 - Wikipedia:Golgi_apparatus - Golgi complex - Golgi ribbon - cellular_component - GO:0005794 - - - - - - - - - - Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. - Golgi apparatus - - - - - A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. - ISBN:0198506732 - - - - - - - - - Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. - NIF_Subcellular:sao819927218 - cellular_component - Golgi vesicle - vesicular component - GO:0005798 - Note that this definition includes vesicles that are transiently associated with the Golgi. - Golgi-associated vesicle - - - - - Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. - GOC:mah - - - - - vesicular component - NIF_Subcellular:sao138219748 - - - - - - - - - - - - - - - - - - - - - - - - - - - - An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. - GO:0033279 - NIF_Subcellular:sao1429207766 - Wikipedia:Ribosome - free ribosome - membrane bound ribosome - cellular_component - ribosomal RNA - GO:0005840 - - - - - - - - - ribosome - - - - - An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. - ISBN:0198506732 - - - - - free ribosome - NIF_Subcellular:sao1139385046 - - - - - membrane bound ribosome - NIF_Subcellular:sao1291545653 - - - - - - - - - A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. - Wikipedia:Cytoskeleton - cellular_component - GO:0005856 - - - - - - - - - - - - cytoskeleton - - - - - A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. - GOC:mah - PMID:16959967 - PMID:27419875 - - - - - - - - - - - - - - - - - - - - - Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. - NIF_Subcellular:sao1846835077 - Wikipedia:Microtubule - microtubuli - microtubulus - neurotubule - cellular_component - GO:0005874 - - microtubule - - - - - Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. - ISBN:0879693568 - - - - - neurotubule - NIF_Subcellular:sao248349196 - - - - - - - - - - - - - - - - - - - - - - - - - - A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules. - cellular_component - GO:0005879 - axonemal microtubule - - - - - A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules. - GOC:cilia - ISBN:0815316194 - - - - - - - - - - - - - - - - - - - - - - - - - - Any microtubule in the nucleus of a cell. - cellular_component - GO:0005880 - nuclear microtubule - - - - - Any microtubule in the nucleus of a cell. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any microtubule in the cytoplasm of a cell. - non-spindle-associated astral microtubule - cellular_component - GO:0005881 - cytoplasmic microtubule - - - - - Any microtubule in the cytoplasm of a cell. - GOC:mah - - - - - - - - - - - - - - - - - - - - - A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. - FMA:63850 - NIF_Subcellular:sao1588493326 - Wikipedia:Actin - microfilament - cellular_component - GO:0005884 - actin filament - - - - - A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. - GOC:mah - ISBN:0198506732 - PMID:10666339 - - - - - - - - - - - - - - - The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. - GO:0005887 - GO:0005904 - juxtamembrane - NIF_Subcellular:sao1663586795 - Wikipedia:Cell_membrane - cell membrane - cellular membrane - cytoplasmic membrane - plasmalemma - bacterial inner membrane - inner endospore membrane - integral component of plasma membrane - integral to plasma membrane - plasma membrane lipid bilayer - cellular_component - GO:0005886 - - - - - - - - - - - plasma membrane - - - - - The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. - ISBN:0716731363 - - - - - cellular membrane - NIF_Subcellular:sao6433132645 - - - - - plasma membrane lipid bilayer - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. - - NIF_Subcellular:sao671419673 - Wikipedia:Microvillus - cellular_component - microvilli - GO:0005902 - - Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. - microvillus - - - - - Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. - ISBN:0815316194 - - - - - microvilli - NIF_Subcellular:sao671419673 - - - - - - - - - A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. - https://github.com/geneontology/go-ontology/issues/22122 - cell-cell contact region - cell-cell contact zone - NIF_Subcellular:sao1922892319 - intercellular junction - cellular_component - GO:0005911 - cell-cell junction - - - - - A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. - GOC:aruk - GOC:bc - GOC:dgh - GOC:hb - GOC:mah - PMID:21422226 - PMID:28096264 - - - - - intercellular junction - NIF_Subcellular:sao1395777368 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. - - - - - - - GO:0072372 - FMA:67181 - NIF_Subcellular:sao787716553 - Wikipedia:Cilium - eukaryotic flagellum - microtubule-based flagellum - primary cilium - cellular_component - flagellum - GO:0005929 - - - - - Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. - cilium - - - - - A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. - GOC:cilia - GOC:curators - GOC:kmv - GOC:vw - ISBN:0198547684 - PMID:16824949 - PMID:17009929 - PMID:20144998 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. - GO:0035085 - GO:0035086 - Wikipedia:Axoneme - ciliary axoneme - cilium axoneme - flagellar axoneme - flagellum axoneme - cellular_component - GO:0005930 - - Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane. - axoneme - - - - - The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. - GOC:bf - GOC:cilia - ISBN:0198547684 - - - - - - - - - - - - - - - - - - - - - - - - - - The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. - Wikipedia:Cell_cortex - cellular_component - cell periphery - peripheral cytoplasm - GO:0005938 - - - cell cortex - - - - - The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. - GOC:mah - ISBN:0815316194 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. - https://github.com/geneontology/go-ontology/issues/22880 - jl - 2012-10-23T15:40:34Z - GO:0044261 - GO:0044723 - Wikipedia:Carbohydrate_metabolism - carbohydrate metabolism - biological_process - GO:0005975 - - - - - - - - - - - - carbohydrate metabolic process - - - - - The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. - GOC:mah - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. - GO:0044263 - polysaccharide metabolism - glycan metabolic process - glycan metabolism - multicellular organismal polysaccharide metabolic process - biological_process - GO:0005976 - - polysaccharide metabolic process - - - - - The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. - ISBN:0198547684 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. - glycogen metabolism - biological_process - GO:0005977 - glycogen metabolic process - - - - - The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. - MetaCyc:GLYCOGENSYNTH-PWY - glycogen anabolism - glycogen biosynthesis - glycogen formation - glycogen synthesis - biological_process - GO:0005978 - glycogen biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. - regulation of glycogen anabolism - regulation of glycogen biosynthesis - regulation of glycogen formation - regulation of glycogen synthesis - biological_process - GO:0005979 - regulation of glycogen biosynthetic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. - MetaCyc:GLYCOCAT-PWY - glycogen breakdown - glycogen catabolism - glycogen degradation - glycogenolysis - biological_process - GO:0005980 - glycogen catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. - ISBN:0198506732 - - - - - glycogenolysis - GOC:sl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. - regulation of glycogen breakdown - regulation of glycogen catabolism - regulation of glycogen degradation - regulation of glycogenolysis - biological_process - GO:0005981 - regulation of glycogen catabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. - GOC:go_curators - - - - - regulation of glycogenolysis - GOC:sl - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. - monosaccharide metabolism - biological_process - GO:0005996 - monosaccharide metabolic process - - - - - The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. - cellular glucose metabolic process - glucose metabolism - biological_process - GO:0006006 - glucose metabolic process - - - - - The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. - ISBN:0198506732 - - - - - cellular glucose metabolic process - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. - glucose breakdown - glucose catabolism - glucose degradation - biological_process - GO:0006007 - glucose catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. - aminoglycan metabolism - biological_process - GO:0006022 - aminoglycan metabolic process - - - - - The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. - GOC:ai - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. - aminoglycan anabolism - aminoglycan biosynthesis - aminoglycan formation - aminoglycan synthesis - biological_process - GO:0006023 - aminoglycan biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. - GOC:ai - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. - glycosaminoglycan anabolism - glycosaminoglycan biosynthesis - glycosaminoglycan formation - glycosaminoglycan synthesis - biological_process - GO:0006024 - glycosaminoglycan biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. - ISBN:0192800981 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. - aminoglycan breakdown - aminoglycan catabolism - aminoglycan degradation - biological_process - GO:0006026 - aminoglycan catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. - GOC:ai - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. - glycosaminoglycan breakdown - glycosaminoglycan catabolism - glycosaminoglycan degradation - biological_process - GO:0006027 - glycosaminoglycan catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. - ISBN:0192800981 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. - organic acid metabolism - biological_process - GO:0006082 - - organic acid metabolic process - - - - - The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving acetate, the anion of acetic acid. - acetate metabolism - biological_process - GO:0006083 - acetate metabolic process - - - - - The chemical reactions and pathways involving acetate, the anion of acetic acid. - GOC:go_curators - - - - - - - - - The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. - energy pathways - biological_process - intermediary metabolism - metabolic energy generation - GO:0006091 - - - - - - - - - - - generation of precursor metabolites and energy - - - - - The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. - GOC:jl - - - - - intermediary metabolism - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. - MetaCyc:GLUCONEO-PWY - Wikipedia:Gluconeogenesis - glucose biosynthesis - glucose biosynthetic process - biological_process - GO:0006094 - gluconeogenesis - - - - - The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. - MetaCyc:GLUCONEO-PWY - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. - regulation of carbohydrate metabolism - biological_process - GO:0006109 - regulation of carbohydrate metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. - tb - 2013-01-18T12:47:43Z - GO:0090526 - regulation of glucose biosynthesis - regulation of glucose biosynthetic process - biological_process - regulation of gluconeogenesis involved in cellular glucose homeostasis - GO:0006111 - regulation of gluconeogenesis - - - - - Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. - GOC:go_curators - - - - - - - - - The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. - energy reserve metabolism - biological_process - GO:0006112 - - energy reserve metabolic process - - - - - The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. - GO:0055134 - cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism - nucleobase, nucleoside, nucleotide and nucleic acid metabolism - biological_process - nucleobase, nucleoside and nucleotide metabolic process - nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - GO:0006139 - - - nucleobase-containing compound metabolic process - - - - - Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. - GOC:ai - - - - - nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. - GO:0055132 - DNA metabolism - cellular DNA metabolism - biological_process - GO:0006259 - - - - - - - - DNA metabolic process - - - - - Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. - DNA breakdown - DNA catabolism - DNA degradation - biological_process - GO:0006308 - DNA catabolic process - - - - - The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. - GOC:go_curators - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. - https://github.com/geneontology/go-ontology/issues/24396 - GO:0008178 - DNA fragmentation - chromatinolysis - DNA catabolic process during apoptosis - DNA catabolism during apoptosis - DNA fragmentation involved in apoptotic nuclear change - endonucleolytic DNA catabolic process involved in apoptosis - biological_process - GO:0006309 - DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). - apoptotic DNA fragmentation - - - - - The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. - GOC:dph - GOC:mah - GOC:mtg_apoptosis - GOC:tb - ISBN:0721639976 - PMID:15723341 - PMID:23379520 - - - - - chromatinolysis - GOC:mtg_apoptosis - - - - - DNA fragmentation involved in apoptotic nuclear change - GOC:cjm - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. - https://github.com/geneontology/go-ontology/issues/22130 - https://github.com/geneontology/go-ontology/issues/23549 - GO:0006333 - GO:0006336 - GO:0016568 - GO:0031497 - GO:0034724 - chromatin maintenance - chromatin organisation - establishment of chromatin architecture - establishment or maintenance of chromatin architecture - DNA replication-independent chromatin assembly - DNA replication-independent chromatin organization - DNA replication-independent nucleosome organisation - DNA replication-independent nuclesome assembly - chromatin assembly - transcription-coupled nucleosome assembly - biological_process - chromatin assembly or disassembly - chromatin assembly/disassembly - chromatin modification - GO:0006325 - - - - chromatin organization - - - - - The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. - PMID:20404130 - - - - - chromatin organisation - GOC:mah - - - - - establishment of chromatin architecture - GOC:mah - - - - - establishment or maintenance of chromatin architecture - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. - RNA breakdown - RNA catabolism - RNA degradation - biological_process - GO:0006401 - - RNA catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. - ISBN:0198506732 - - - - - - - - - A process in which RNA is transported to, or maintained in, a specific location. - RNA localisation - establishment and maintenance of RNA localization - biological_process - GO:0006403 - - RNA localization - - - - - A process in which RNA is transported to, or maintained in, a specific location. - GOC:ai - - - - - RNA localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. - GO:0006416 - GO:0006453 - GO:0043037 - Wikipedia:Translation_(genetics) - protein anabolism - protein biosynthesis - protein biosynthetic process - protein formation - protein synthesis - protein translation - biological_process - GO:0006412 - - - - - - - - translation - - - - - The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. - GO:0006440 - GO:0006454 - biopolymerisation - biopolymerization - protein synthesis initiation - translation initiation - biological_process - GO:0006413 - - translational initiation - - - - - The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. - ISBN:019879276X - - - - - - - - - - - - - - - The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. - GO:0006442 - GO:0006455 - protein synthesis elongation - translation elongation - biological_process - GO:0006414 - - translational elongation - - - - - The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. - GOC:ems - - - - - - - - - - - - - - - The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). - GO:0006443 - GO:0006456 - protein synthesis termination - translation termination - translational complex disassembly - biological_process - GO:0006415 - translational termination - - - - - The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). - GOC:hjd - ISBN:019879276X - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. - GO:0006445 - regulation of protein anabolism - regulation of protein biosynthesis - regulation of protein formation - regulation of protein synthesis - biological_process - GO:0006417 - - regulation of translation - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. - GOC:isa_complete - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of translational initiation. - biological_process - GO:0006446 - regulation of translational initiation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of translational initiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, extent or accuracy of translational elongation. - biological_process - GO:0006448 - regulation of translational elongation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate, extent or accuracy of translational elongation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of translational termination. - biological_process - GO:0006449 - regulation of translational termination - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of translational termination. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. - glycoprotein breakdown - glycoprotein catabolism - glycoprotein degradation - biological_process - GO:0006516 - glycoprotein catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. - GOC:go_curators - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. - peptide metabolism - biological_process - GO:0006518 - - peptide metabolic process - - - - - The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. - https://github.com/geneontology/go-ontology/issues/17904 - GO:0006519 - cellular amino acid metabolic process - cellular amino acid metabolism - biological_process - amino acid and derivative metabolism - cellular amino acid and derivative metabolic process - GO:0006520 - - - - - - - - amino acid metabolic process - - - - - The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. - regulation of amino acid metabolism - biological_process - GO:0006521 - regulation of cellular amino acid metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. - GOC:go_curators - - - - - - - - - The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. - biogenic amine metabolism - cellular biogenic amine metabolic process - biological_process - GO:0006576 - biogenic amine metabolic process - - - - - The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. - GOC:jl - ISBN:0395825172 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline. - acetylcholine breakdown - acetylcholine catabolism - acetylcholine degradation - biological_process - GO:0006581 - acetylcholine catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline. - GOC:jl - ISBN:0192800752 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. - catecholamine metabolism - biological_process - GO:0006584 - catecholamine metabolic process - - - - - The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. - indolamine metabolic process - indolamine metabolism - indolalkylamine metabolism - biological_process - GO:0006586 - indolalkylamine metabolic process - - - - - The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. - GOC:curators - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. - Wikipedia:Lipid_metabolism - lipid metabolism - biological_process - GO:0006629 - - - - - - - - - - - - - lipid metabolic process - - - - - The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. - GOC:ma - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. - Wikipedia:Steroid_metabolisms#Steroid_biosynthesis - steroid anabolism - steroid biosynthesis - steroid formation - steroid synthesis - steroidogenesis - biological_process - GO:0006694 - steroid biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. - bile acid anabolism - bile acid biosynthesis - bile acid formation - bile acid synthesis - biological_process - GO:0006699 - bile acid biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. - steroid breakdown - steroid catabolism - steroid degradation - biological_process - GO:0006706 - steroid catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. - aromatic compound metabolism - aromatic hydrocarbon metabolic process - aromatic hydrocarbon metabolism - biological_process - GO:0006725 - - cellular aromatic compound metabolic process - - - - - The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. - GOC:ai - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. - Wikipedia:Sulfur_metabolism - sulfur metabolism - sulphur metabolic process - sulphur metabolism - biological_process - GO:0006790 - - - - - - - sulfur compound metabolic process - - - - - The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4). - phosphorus metabolism - biological_process - GO:0006793 - - phosphorus metabolic process - - - - - The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4). - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. - phosphate metabolism - biological_process - phosphate metabolic process - GO:0006796 - phosphate-containing compound metabolic process - - - - - The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. - nitrogen compound metabolism - biological_process - GO:0006807 - - - nitrogen compound metabolic process - - - - - The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. - GOC:jl - ISBN:0198506732 - - - - - - - - - The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. - https://github.com/geneontology/go-ontology/issues/20292 - jl - 2012-12-13T16:25:32Z - GO:0015457 - GO:0015460 - GO:0044765 - biological_process - single-organism transport - GO:0006810 - - - - - - - - Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. - transport - - - - - The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. - GOC:dos - GOC:dph - GOC:jl - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. - ion transport - biological_process - GO:0006811 - - - - monoatomic ion transport - - - - - The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. - GO:0006819 - GO:0015674 - GO:0072512 - cation transport - di-, tri-valent inorganic cation transport - trivalent inorganic cation transport - biological_process - GO:0006812 - monoatomic cation transport - - - - - The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. - GOC:ai - - - - - di-, tri-valent inorganic cation transport - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GO:0006834 - GO:0016974 - sodium/potassium transport - sodium transport - mitochondrial sodium/calcium ion exchange - sodium:calcium exchange - sodium:solute transport - biological_process - sodium channel auxiliary protein activity - GO:0006814 - sodium ion transport - - - - - The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - sodium channel auxiliary protein activity - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - phosphate transport - GO:0006817 - phosphate ion transport - - - - - The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GO:0006841 - biological_process - sodium:dicarboxylate transport - GO:0006835 - dicarboxylic acid transport - - - - - The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:krc - - - - - - - - - - - - - - - - - - - - - The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. - sodium:neurotransmitter transport - biological_process - GO:0006836 - - neurotransmitter transport - - - - - The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. - biological_process - GO:0006837 - serotonin transport - - - - - The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0006846 - acetate transport - - - - - The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of acetate across a plasma membrane. - biological_process - GO:0006847 - plasma membrane acetate transport - - - - - The directed movement of acetate across a plasma membrane. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The transport of substances that occurs outside cells. - biological_process - GO:0006858 - extracellular transport - - - - - The transport of substances that occurs outside cells. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed extracellular movement of amino acids. - biological_process - GO:0006860 - extracellular amino acid transport - - - - - The directed extracellular movement of amino acids. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GO:0006866 - biological_process - GO:0006865 - - - amino acid transport - - - - - The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. - biological_process - GO:0006869 - - - - lipid transport - - - - - The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. - GO:0032779 - biological_process - copper-induced intracellular protein transport - GO:0006886 - - - intracellular protein transport - - - - - The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. - GOC:mah - - - - - copper-induced intracellular protein transport - GOC:al - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. - GO:0016194 - GO:0016195 - Wikipedia:Exocytosis - vesicle exocytosis - biological_process - nonselective vesicle exocytosis - GO:0006887 - - exocytosis - - - - - A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. - GOC:mah - ISBN:0716731363 - PMID:22323285 - - - - - - - - - The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. - post-Golgi transport - biological_process - GO:0006892 - post-Golgi vesicle-mediated transport - - - - - The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. - GOC:ai - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. - Golgi to plasma membrane vesicle-mediated transport - biological_process - GO:0006893 - Golgi to plasma membrane transport - - - - - The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. - ISBN:0716731363 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of substances from the Golgi to the vacuole. - Golgi to vacuole vesicle-mediated transport - biological_process - GO:0006896 - Golgi to vacuole transport - - - - - The directed movement of substances from the Golgi to the vacuole. - GOC:ai - - - - - - - - - - - - - - - - - - - - - The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. - biological_process - GO:0006903 - vesicle targeting - - - - - The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. - GOC:mah - PMID:17335816 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Fusion of the membrane of a transport vesicle with its target membrane. - biological_process - GO:0006906 - vesicle fusion - - - - - Fusion of the membrane of a transport vesicle with its target membrane. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. - - - GO:0006917 - GO:0008632 - cell suicide - cellular suicide - Wikipedia:Apoptosis - apoptotic cell death - apoptotic programmed cell death - programmed cell death by apoptosis - activation of apoptosis - apoptosis - apoptosis signaling - apoptotic program - type I programmed cell death - biological_process - apoptosis activator activity - caspase-dependent programmed cell death - commitment to apoptosis - induction of apoptosis - induction of apoptosis by p53 - signaling (initiator) caspase activity - GO:0006915 - apoptotic process - - - - - A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. - GOC:cjm - GOC:dhl - GOC:ecd - GOC:go_curators - GOC:mtg_apoptosis - GOC:tb - ISBN:0198506732 - PMID:18846107 - PMID:21494263 - - - - - apoptotic cell death - GOC:sl - - - - - apoptotic program - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. - cellular component disassembly involved in apoptotic process - disassembly of cell structures - cellular component disassembly involved in apoptosis - biological_process - GO:0006921 - cellular component disassembly involved in execution phase of apoptosis - - - - - The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. - GOC:dph - GOC:mah - GOC:mtg_apoptosis - GOC:tb - - - - - - - - - - - - - - - A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. - Wikipedia:Muscle_contraction - biological_process - GO:0006936 - - muscle contraction - - - - - A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. - GOC:ef - GOC:mtg_muscle - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of muscle contraction. - biological_process - GO:0006937 - regulation of muscle contraction - - - - - Any process that modulates the frequency, rate or extent of muscle contraction. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. - visceral muscle contraction - biological_process - GO:0006939 - smooth muscle contraction - - - - - A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. - GOC:ef - GOC:jl - GOC:mtg_muscle - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of smooth muscle contraction. - biological_process - GO:0006940 - regulation of smooth muscle contraction - - - - - Any process that modulates the frequency, rate or extent of smooth muscle contraction. - GOC:go_curators - - - - - - - - - - - - - - - A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. - sarcomeric muscle contraction - biological_process - GO:0006941 - striated muscle contraction - - - - - A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. - GOC:jl - GOC:mtg_muscle - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of striated muscle contraction. - biological_process - GO:0006942 - regulation of striated muscle contraction - - - - - Any process that modulates the frequency, rate or extent of striated muscle contraction. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. - biological_process - GO:0006949 - - syncytium formation - - - - - The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. - ISBN:0198506732 - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). - biological_process - response to abiotic stress - response to biotic stress - GO:0006950 - - - - - - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - response to stress - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). - GOC:mah - - - - - - - - - - Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. - biological_process - GO:0006955 - - immune response - - - - - Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. - GOC:add - GO_REF:0000022 - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. - jl - 2013-12-19T15:25:51Z - GO:1902589 - organelle organisation - single organism organelle organization - biological_process - organelle organization and biogenesis - single-organism organelle organization - GO:0006996 - - - organelle organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. - GOC:mah - - - - - single organism organelle organization - GOC:TermGenie - - - - - organelle organization and biogenesis - GOC:dph - GOC:jl - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. - GO:0048287 - nuclear organisation - nuclear organization - biological_process - nuclear morphology - nuclear organization and biogenesis - nucleus organization and biogenesis - GO:0006997 - - - - - nucleus organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. - GOC:dph - GOC:ems - GOC:jl - GOC:mah - - - - - nuclear organization and biogenesis - GOC:mah - - - - - nucleus organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. - nuclear envelope organisation - biological_process - nuclear envelope organization and biogenesis - GO:0006998 - nuclear envelope organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. - GOC:dph - GOC:ems - GOC:jl - GOC:mah - - - - - nuclear envelope organisation - GOC:mah - - - - - nuclear envelope organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus. - nucleolus organisation - biological_process - nucleolus organization and biogenesis - GO:0007000 - nucleolus organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus. - GOC:dph - GOC:jid - GOC:jl - GOC:mah - - - - - nucleolus organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. - plasma membrane organisation - biological_process - plasma membrane organization and biogenesis - GO:0007009 - - plasma membrane organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. - GOC:dph - GOC:jl - GOC:mah - - - - - plasma membrane organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. - cytoskeleton organisation - biological_process - cytoskeletal organization and biogenesis - cytoskeletal regulator activity - cytoskeleton organization and biogenesis - GO:0007010 - - - - - - - cytoskeleton organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. - GOC:dph - GOC:jl - GOC:mah - - - - - cytoskeletal organization and biogenesis - GOC:mah - - - - - cytoskeleton organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. - actin filament organisation - regulation of actin filament localization - biological_process - GO:0007015 - actin filament organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. - https://github.com/geneontology/go-ontology/issues/19809 - biological_process - GO:0007017 - - microtubule-based process - - - - - Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. - GOC:mah - - - - - - - - - A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. - biological_process - GO:0007018 - - - microtubule-based movement - - - - - A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. - GOC:cjm - ISBN:0815316194 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The removal of tubulin heterodimers from one or both ends of a microtubule. - microtubule disassembly - microtubule shortening - microtubule catastrophe - microtubule depolymerization during nuclear congression - biological_process - GO:0007019 - microtubule depolymerization - - - - - The removal of tubulin heterodimers from one or both ends of a microtubule. - ISBN:0815316194 - - - - - microtubule catastrophe - GOC:dph - GOC:tb - - - - - - - - - - - - - - - The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). - Wikipedia:Microtubule_nucleation - biological_process - GO:0007020 - microtubule nucleation - - - - - The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). - GOC:go_curators - ISBN:0815316194 - PMID:12517712 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol. - down regulation of microtubule depolymerization - down-regulation of microtubule depolymerization - downregulation of microtubule depolymerization - microtubule stabilization - negative regulation of microtubule disassembly - inhibition of microtubule depolymerization - microtubule rescue - negative regulation of microtubule catastrophe - biological_process - GO:0007026 - negative regulation of microtubule depolymerization - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol. - GOC:mah - ISBN:0815316194 - - - - - microtubule rescue - GOC:dph - GOC:tb - - - - - negative regulation of microtubule catastrophe - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme. - axonemal microtubule stabilization - biological_process - negative regulation of microtubule depolymerization in axoneme - GO:0007027 - negative regulation of axonemal microtubule depolymerization - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme. - GOC:dph - GOC:mah - - - - - negative regulation of microtubule depolymerization in axoneme - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. - cytoplasm organisation - biological_process - cytoplasm organization and biogenesis - GO:0007028 - - cytoplasm organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. - GOC:curators - GOC:dph - GOC:jl - GOC:mah - - - - - cytoplasm organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. - Golgi apparatus organization - Golgi organisation - biological_process - Golgi organization and biogenesis - GO:0007030 - - Golgi organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. - GOC:dph - GOC:jl - GOC:mah - - - - - Golgi organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. - GO:0044086 - vacuole organisation - vacuolar assembly - biological_process - vacuole biogenesis - vacuole organization and biogenesis - GO:0007033 - - - - vacuole organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. - GOC:mah - - - - - vacuolar assembly - GOC:mah - - - - - vacuole biogenesis - GOC:mah - - - - - vacuole organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of substances into, out of or within a vacuole. - biological_process - GO:0007034 - - vacuolar transport - - - - - The directed movement of substances into, out of or within a vacuole. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases. - biological_process - vacuolar protein breakdown - vacuolar protein catabolic process - vacuolar protein catabolism - vacuolar protein degradation - GO:0007039 - protein catabolic process in the vacuole - - - - - The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases. - GOC:mah - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of a set of components to form a junction between cells. - intercellular junction assembly - biological_process - GO:0007043 - cell-cell junction assembly - - - - - The aggregation, arrangement and bonding together of a set of components to form a junction between cells. - GOC:ai - - - - - - - - - The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. - Wikipedia:Cell_cycle - cell-division cycle - biological_process - GO:0007049 - - - - - - - - cell cycle - - - - - The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. - GOC:go_curators - GOC:mtg_cell_cycle - - - - - - - - - The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. - Wikipedia:Chromosome_segregation - chromosome division - biological_process - chromosome transmission - GO:0007059 - - - - - - - chromosome segregation - - - - - The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. - GOC:jl - GOC:mah - GOC:mtg_cell_cycle - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. - biological_process - GO:0007076 - mitotic chromosome condensation - - - - - The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. - GOC:mah - ISBN:0815316194 - - - - - - - - - - - - - - - - - - - - - - - - - - - The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis. - NEB - local NEB - nuclear envelope breakdown - mitotic nuclear envelope breakdown - biological_process - mitotic nuclear envelope catabolism - mitotic nuclear envelope degradation - mitotic nuclear envelope disassembly - GO:0007077 - mitotic nuclear membrane disassembly - - - - - The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis. - GOC:bf - PMID:32848252 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of mitosis. - regulation of mitosis - biological_process - GO:0007088 - regulation of mitotic nuclear division - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of mitosis. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of the nucleus to a specific location within a cell. - GO:0040023 - establishment of position of nucleus - nuclear movement - nuclear positioning - nucleus migration - nucleus positioning - positioning of nucleus - biological_process - establishment of cell nucleus localization - establishment of localization of nucleus - establishment of nucleus localisation - establishment of nucleus localization - GO:0007097 - nuclear migration - - - - - The directed movement of the nucleus to a specific location within a cell. - GOC:ai - - - - - establishment of nucleus localisation - GOC:mah - - - - - - - - - A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell. - Wikipedia:Mitosis#Endomitosis - biological_process - endomitosis - GO:0007113 - Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins. - endomitotic cell cycle - - - - - A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell. - GOC:curators - GOC:dos - GOC:expert_vm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. - - female meiosis - female meiotic division - biological_process - GO:0007143 - Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'. - female meiotic nuclear division - - - - - A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. - GOC:dph - GOC:ems - GOC:mah - GOC:vw - - - - - - - - - Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - Wikipedia:Cell_signaling - biological_process - GO:0007154 - - - cell communication - - - - - Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - GOC:mah - - - - - - - - - Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. - GO:0030012 - GO:0030467 - biological_process - cell polarity - establishment and/or maintenance of cell polarity - establishment and/or maintenance of cell polarization - GO:0007163 - - - - - establishment or maintenance of cell polarity - - - - - Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. - GOC:mah - - - - - cell polarity - GOC:mah - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - - - The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. - GO:0023014 - GO:0023015 - GO:0023016 - GO:0023033 - GO:0023045 - Wikipedia:Signal_transduction - signal transduction by cis-phosphorylation - signal transduction by conformational transition - signal transduction by protein phosphorylation - signal transduction by trans-phosphorylation - signaling cascade - signalling cascade - biological_process - signaling pathway - signalling pathway - GO:0007165 - - - - - Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. - signal transduction - - - - - The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. - GOC:go_curators - GOC:mtg_signaling_feb11 - - - - - signalling pathway - GOC:mah - - - - - - - - - - Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. - cell-cell signalling - biological_process - GO:0007267 - - - cell-cell signaling - - - - - Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. - GOC:dos - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. - signal transmission across a synapse - synaptic transmission - Wikipedia:Neurotransmission - biological_process - neurotransmission - GO:0007268 - - chemical synaptic transmission - - - - - The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. - GOC:jl - MeSH:D009435 - - - - - neurotransmission - GOC:dph - - - - - - - - - - - - - - - - - The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. - GO:0010554 - neurotransmitter release - neurotransmitter secretory pathway - biological_process - GO:0007269 - - A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. - neurotransmitter secretion - - - - - The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. - GOC:dph - - - - - - - - - - - - - - - The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. - cholinergic synaptic transmission - biological_process - GO:0007271 - synaptic transmission, cholinergic - - - - - The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. - GOC:dos - Wikipedia:Cholinergic - - - - - - - - - - - - - - - - - - - - - - - - - - - The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). - https://github.com/geneontology/go-ontology/issues/21234 - biological_process - GO:0007275 - - - - Note that this term was 'developmental process'. - multicellular organism development - - - - - The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). - GOC:dph - GOC:ems - GOC:isa_complete - GOC:tb - - - - - - - - - - - - - - - The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. - GO:0009552 - biological_process - gametogenesis - GO:0007276 - gamete generation - - - - - The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. - GOC:ems - GOC:mtg_sensu - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. - germ-cell development - gametogenesis - primordial germ cell development - biological_process - GO:0007281 - germ cell development - - - - - The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. - GOC:go_curators - - - - - - - - - Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. - biological_process - GO:0007292 - female gamete generation - - - - - Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. - GOC:dph - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster. - biological_process - GO:0007293 - germarium-derived egg chamber formation - - - - - Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster. - GOC:mtg_sensu - ISBN:0879694238 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster. - GO:0048110 - oocyte arrangement - biological_process - GO:0007308 - oocyte construction - - - - - The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster. - GOC:dph - GOC:ems - GOC:mtg_sensu - GOC:tb - ISBN:0198506732 - - - - - oocyte arrangement - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate or extent of progress through the mitotic cell cycle. - mitotic cell cycle modulation - mitotic cell cycle regulation - modulation of mitotic cell cycle progression - regulation of mitotic cell cycle progression - regulation of progression through mitotic cell cycle - biological_process - mitotic cell cycle regulator - GO:0007346 - regulation of mitotic cell cycle - - - - - Any process that modulates the rate or extent of progress through the mitotic cell cycle. - GOC:dph - GOC:go_curators - GOC:tb - - - - - regulation of progression through mitotic cell cycle - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. - Wikipedia:Gastrulation - biological_process - GO:0007369 - - gastrulation - - - - - A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. - GOC:curators - ISBN:9780878933846 - - - - - - - - - - - - - - - Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. - biological_process - pattern biosynthesis - pattern formation - GO:0007389 - - pattern specification process - - - - - Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. - GOC:go_curators - GOC:isa_complete - ISBN:0521436125 - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. - biological_process - GO:0007398 - ectoderm development - - - - - The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. - biological_process - pan-neural process - GO:0007399 - - nervous system development - - - - - The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. - GOC:dgh - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. - GO:0043349 - GO:0043350 - biological_process - GO:0007405 - neuroblast proliferation - - - - - The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. - GOC:ai - GOC:mtg_sensu - GOC:sart - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts. - down regulation of neuroblast proliferation - down-regulation of neuroblast proliferation - downregulation of neuroblast proliferation - suppression of neuroblast proliferation - inhibition of neuroblast proliferation - biological_process - GO:0007406 - negative regulation of neuroblast proliferation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). - Wikipedia:Synaptogenesis - synapse biogenesis - synaptogenesis - biological_process - GO:0007416 - - synapse assembly - - - - - The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). - GOC:mah - - - - - synapse biogenesis - GOC:mah - - - - - synaptogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. - Wikipedia:Neural_development - CNS development - biological_process - GO:0007417 - central nervous system development - - - - - The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. - GOC:bf - GOC:jid - ISBN:0582227089 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). - biological_process - GO:0007420 - brain development - - - - - The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). - GOC:dph - GOC:jid - GOC:tb - UBERON:0000955 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. - biological_process - GO:0007422 - peripheral nervous system development - - - - - The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. - GOC:go_curators - UBERON:0000010 - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. - sense organ development - biological_process - GO:0007423 - - sensory organ development - - - - - The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. - GOC:go_curators - - - - - sense organ development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm. - biological_process - ectodermal gut development - GO:0007439 - ectodermal digestive tract development - - - - - The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm. - GOC:curators - - - - - ectodermal gut development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the foregut are generated and organized. - biological_process - GO:0007440 - foregut morphogenesis - - - - - The process in which the anatomical structures of the foregut are generated and organized. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the hindgut are generated and organized. - biological_process - GO:0007442 - hindgut morphogenesis - - - - - The process in which the anatomical structures of the hindgut are generated and organized. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. - biological_process - GO:0007492 - endoderm development - - - - - The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. - biological_process - GO:0007494 - midgut development - - - - - The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. - GOC:jid - UBERON:0001045 - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. - biological_process - GO:0007498 - - mesoderm development - - - - - The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism. - biological_process - GO:0007506 - gonadal mesoderm development - - - - - The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. - GO:0007511 - Wikipedia:Heart_development - dorsal vessel development - biological_process - cardiac development - GO:0007507 - heart development - - - - - The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. - GOC:jid - UBERON:0000948 - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. - biological_process - GO:0007517 - muscle organ development - - - - - The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. - GOC:jid - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. - GO:0048637 - biological_process - myogenesis - GO:0007519 - skeletal muscle tissue development - - - - - The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. - neuromuscular junction organization - biological_process - NMJ stability - neuromuscular junction stability - GO:0007528 - neuromuscular junction development - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. - GOC:mtg_OBO2OWL_2013 - - - - - NMJ stability - GOC:pr - - - - - neuromuscular junction stability - GOC:pr - - - - - - - - - The establishment of the sex of an organism by physical differentiation. - Wikipedia:Sexual_differentiation - biological_process - GO:0007548 - sex differentiation - - - - - The establishment of the sex of an organism by physical differentiation. - GOC:ai - - - - - - - - - The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. - breathing - respiration - biological_process - GO:0007585 - - respiratory gaseous exchange by respiratory system - - - - - The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. - ISBN:0198506732 - - - - - - - - - The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. - Wikipedia:Digestion - biological_process - GO:0007586 - - - digestion - - - - - The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. - GOC:isa_complete - ISBN:0198506732 - - - - - - - - - The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. - https://github.com/geneontology/go-ontology/issues/22368 - Wikipedia:Excretion - biological_process - GO:0007588 - - - excretion - - - - - The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. - ISBN:0192801023 - - - - - - - - - The controlled release of a fluid by a cell or tissue in an animal. - biological_process - GO:0007589 - body fluid secretion - - - - - The controlled release of a fluid by a cell or tissue in an animal. - GOC:ai - GOC:dph - GOC:mah - GOC:tb - - - - - - - - - The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. - Wikipedia:Perception - biological_process - GO:0007600 - - sensory perception - - - - - The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. - GOC:ai - GOC:dph - - - - - - - - - The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. - Wikipedia:Visual_perception - sense of sight - sensory visual perception - vision - biological_process - GO:0007601 - visual perception - - - - - The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. - GOC:ai - - - - - - - - - The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. - Wikipedia:Hearing_(sense) - hearing - perception of sound - biological_process - GO:0007605 - sensory perception of sound - - - - - The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. - GOC:ai - - - - - - - - - The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. - chemosensory perception - biological_process - GO:0007606 - sensory perception of chemical stimulus - - - - - The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. - jl - 2012-09-20T14:06:08Z - GO:0023032 - GO:0044708 - GO:0044709 - Wikipedia:Behavior - behavioral response to stimulus - behaviour - behavioural response to stimulus - biological_process - single-organism behavior - GO:0007610 - - - - 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews. -2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis). - behavior - - - - - The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. - GOC:ems - GOC:jl - ISBN:0395448956 - PMID:20160973 - - - - - - - - - The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. - behavior via locomotion - locomotion in response to stimulus - locomotory behavioral response to stimulus - locomotory behaviour - locomotory behavioural response to stimulus - biological_process - GO:0007626 - - locomotory behavior - - - - - The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. - GOC:dph - - - - - - - - - The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. - GO:0070261 - biological_process - hemolymph circulation - GO:0008015 - - blood circulation - - - - - The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. - GOC:mtg_heart - ISBN:0192800825 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. - regulation of cardiac contraction - biological_process - GO:0008016 - regulation of heart contraction - - - - - Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. - GOC:dph - GOC:go_curators - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. - GO:0008505 - Reactome:R-HSA-429749 - Reactome:R-HSA-433698 - Reactome:R-HSA-5624211 - Reactome:R-HSA-9645220 - monocarboxylate carrier - prostaglandin/thromboxane transporter activity - molecular_function - GO:0008028 - monocarboxylic acid transmembrane transporter activity - - - - - Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. - GOC:ai - - - - - Reactome:R-HSA-429749 - SLC5A8 transports monocarboxylates from extracellular region to cytosol - - - - - Reactome:R-HSA-433698 - SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - - - - - Reactome:R-HSA-5624211 - Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol - - - - - Reactome:R-HSA-9645220 - SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of organelles or molecules along microtubules in neuron projections. - Wikipedia:Axoplasmic_transport - axon cargo transport - axonal transport - axoplasmic transport - biological_process - GO:0008088 - - axo-dendritic transport - - - - - The directed movement of organelles or molecules along microtubules in neuron projections. - ISBN:0815316194 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a protein is transported to, or maintained in, a specific location. - https://github.com/geneontology/go-ontology/issues/23112 - GO:0008105 - GO:0016249 - GO:0034613 - cellular protein localisation - cellular protein localization - protein localisation - channel localizer activity - biological_process - asymmetric protein localisation - asymmetric protein localization - establishment and maintenance of asymmetric protein localization - establishment and maintenance of protein localization - GO:0008104 - - protein localization - - - - - Any process in which a protein is transported to, or maintained in, a specific location. - GOC:ai - - - - - cellular protein localisation - GOC:mah - - - - - protein localisation - GOC:mah - - - - - channel localizer activity - GOC:mah - - - - - asymmetric protein localisation - GOC:mah - - - - - - - - - A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. - https://github.com/geneontology/go-ontology/issues/24968 - jl - 2012-09-19T15:05:24Z - GO:0000004 - GO:0007582 - GO:0044699 - Wikipedia:Biological_process - biological process - physiological process - biological_process - single organism process - single-organism process - GO:0008150 - - - - - - - - Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. - biological_process - - - - - A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. - GOC:pdt - - - - - - - - - - The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. - jl - 2012-10-17T15:46:40Z - GO:0044236 - GO:0044710 - Wikipedia:Metabolism - metabolism - metabolic process resulting in cell growth - metabolism resulting in cell growth - multicellular organism metabolic process - biological_process - single-organism metabolic process - GO:0008152 - - - - - - Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. - metabolic process - - - - - The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. - GOC:go_curators - ISBN:0198547684 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. - Wikipedia:Steroid_metabolism - steroid metabolism - biological_process - GO:0008202 - steroid metabolic process - - - - - The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. - ISBN:0198547684 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. - bile acid metabolism - biological_process - GO:0008206 - bile acid metabolic process - - - - - The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. - GOC:go_curators - - - - - - - - - Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). - https://github.com/geneontology/go-ontology/issues/24680 - biological_process - accidental cell death - necrosis - GO:0008219 - - This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms. - cell death - - - - - Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). - GOC:mah - GOC:mtg_apoptosis - PMID:25236395 - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GO:0006870 - sulphate transport - biological_process - GO:0008272 - sulfate transport - - - - - The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of cells, resulting in the expansion of a cell population. - - biological_process - cell proliferation - GO:0008283 - - - - - - - This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. - cell population proliferation - - - - - The multiplication or reproduction of cells, resulting in the expansion of a cell population. - GOC:mah - GOC:mb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the rate or extent of cell proliferation. - - up regulation of cell proliferation - up-regulation of cell proliferation - upregulation of cell proliferation - activation of cell proliferation - stimulation of cell proliferation - biological_process - positive regulation of cell proliferation - GO:0008284 - positive regulation of cell population proliferation - - - - - Any process that activates or increases the rate or extent of cell proliferation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the rate or extent of cell proliferation. - - down regulation of cell proliferation - down-regulation of cell proliferation - downregulation of cell proliferation - inhibition of cell proliferation - biological_process - negative regulation of cell proliferation - GO:0008285 - negative regulation of cell population proliferation - - - - - Any process that stops, prevents or reduces the rate or extent of cell proliferation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. - acetylcholine metabolism - biological_process - GO:0008291 - acetylcholine metabolic process - - - - - The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. - GOC:jl - GOC:nln - ISBN:0192800752 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline. - acetylcholine anabolism - acetylcholine biosynthesis - acetylcholine formation - acetylcholine synthesis - biological_process - GO:0008292 - acetylcholine biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline. - GOC:jl - ISBN:0192800752 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of a protein from one side of a membrane to the other. - GO:0015266 - GO:0015463 - Reactome:R-HSA-1268022 - Reactome:R-HSA-1299475 - Reactome:R-HSA-184269 - Reactome:R-HSA-3149434 - Reactome:R-HSA-5205661 - Reactome:R-HSA-5210943 - Reactome:R-HSA-5210947 - Reactome:R-HSA-5228406 - Reactome:R-HSA-5229111 - Reactome:R-HSA-5244404 - Reactome:R-HSA-5244428 - Reactome:R-HSA-5244506 - Reactome:R-HSA-5246514 - Reactome:R-HSA-5250616 - Reactome:R-HSA-5250884 - Reactome:R-HSA-5250972 - Reactome:R-HSA-5336420 - Reactome:R-HSA-9636375 - Reactome:R-HSA-9698930 - Reactome:R-HSA-9698933 - molecular_function - protein channel activity - GO:0008320 - protein transmembrane transporter activity - - - - - - - - - - - GO_REF:0000090 - - - - - Enables the transfer of a protein from one side of a membrane to the other. - GOC:jl - - - - - Reactome:R-HSA-1268022 - TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space - - - - - Reactome:R-HSA-1299475 - TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix - - - - - Reactome:R-HSA-184269 - Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex - - - - - Reactome:R-HSA-3149434 - Transport of GAG to the Plasma Membrane - - - - - Reactome:R-HSA-5205661 - Pink1 is recruited from the cytoplasm to the mitochondria - - - - - Reactome:R-HSA-5210943 - pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol) - - - - - Reactome:R-HSA-5210947 - pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) - - - - - Reactome:R-HSA-5228406 - tetX HC transports tetX LC from target cell endosome membrane into cytosol - - - - - Reactome:R-HSA-5229111 - AP4 transports APP from trans-Golgi network to endosome lumen - - - - - Reactome:R-HSA-5244404 - botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol - - - - - Reactome:R-HSA-5244428 - botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol - - - - - Reactome:R-HSA-5244506 - botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol - - - - - Reactome:R-HSA-5246514 - botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol - - - - - Reactome:R-HSA-5250616 - botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol - - - - - Reactome:R-HSA-5250884 - botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol - - - - - Reactome:R-HSA-5250972 - botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol - - - - - Reactome:R-HSA-5336420 - DT fragment B transports DT fragment A from target cell endosome membrane - - - - - Reactome:R-HSA-9636375 - SecA2 transports SapM from cytoplasm to cytosol - - - - - Reactome:R-HSA-9698930 - HCMV C Nucleocapsid Translocation - - - - - Reactome:R-HSA-9698933 - HCMV B Nucleocapsid Translocation - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of cation from one side of a membrane to the other. - https://github.com/geneontology/go-ontology/issues/24479 - cation transmembrane transporter activity - transmembrane cation transporter activity - molecular_function - GO:0008324 - monoatomic cation transmembrane transporter activity - - - - - Enables the transfer of cation from one side of a membrane to the other. - GOC:dgf - GOC:mtg_transport - ISBN:0815340729 - - - - - - - - - The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. - Wikipedia:Asymmetric_cell_division - asymmetrical cell division - biological_process - asymmetric cytokinesis - asymmetrical cytokinesis - GO:0008356 - asymmetric cell division - - - - - The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. - PMID:11672519 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. - gonadogenesis - biological_process - GO:0008406 - gonad development - - - - - The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. - GOC:ems - ISBN:0198506732 - - - - - gonadogenesis - GOC:cjm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other. - GO:0015201 - Reactome:R-HSA-372542 - Reactome:R-HSA-379393 - Reactome:R-HSA-380586 - Reactome:R-HSA-380620 - Reactome:R-HSA-444160 - Reactome:R-HSA-5660706 - molecular_function - GO:0008504 - monoamine transmembrane transporter activity - - - - - Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other. - GOC:mah - - - - - Reactome:R-HSA-372542 - Loading of dopamine into synaptic veiscles - - - - - Reactome:R-HSA-379393 - SLC6A3 cotransports DA, Na+ from extracellular region to cytosol - - - - - Reactome:R-HSA-380586 - loading of Serotonin in synaptic vesicles - - - - - Reactome:R-HSA-380620 - Reuptake of serotonin from the synapse - - - - - Reactome:R-HSA-444160 - VMAT1/2 can mediate the transport of biogenic amines - - - - - Reactome:R-HSA-5660706 - Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. - Reactome:R-HSA-2142859 - Reactome:R-HSA-561041 - Reactome:R-HSA-9794830 - molecular_function - GO:0008514 - organic anion transmembrane transporter activity - - - - - Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. - GOC:ai - - - - - Reactome:R-HSA-2142859 - Growing HA is extruded from the cell by ABCC5 - - - - - Reactome:R-HSA-561041 - OAT1-3 transport organic anions with antiport of dicarboxylic acids - - - - - Reactome:R-HSA-9794830 - SLC22A8 transports Cipro into renal cell - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. - - biological_process - hypodermis development - GO:0008544 - epidermis development - - - - - The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. - GOC:go_curators - UBERON:0001003 - - - - - hypodermis development - GOC:kmv - GOC:rk - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. - - GO:0061039 - biological_process - ovarian development - ovary development - GO:0008585 - female gonad development - - - - - The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. - GOC:dph - GOC:jid - GOC:tb - - - - - ovarian development - GOC:sl - - - - - ovary development - GOC:sl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster. - biological_process - photoreceptor development - GO:0008594 - photoreceptor cell morphogenesis - - - - - The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster. - GOC:jid - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. - lipid anabolism - lipid biosynthesis - lipid formation - lipid synthesis - lipogenesis - biological_process - GO:0008610 - lipid biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. - GOC:go_curators - - - - - lipogenesis - GOC:sl - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. - GO:0006861 - GO:0008644 - sugar transport - biological_process - GO:0008643 - - - carbohydrate transport - - - - - The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule. - bf - 2010-04-08T10:27:23Z - GO:0008646 - GO:0008647 - GO:0035428 - high-affinity hexose transport - low-affinity hexose transport - biological_process - hexose membrane transport - hexose transport - GO:0008645 - Note that this term is not intended for use in annotating lateral movement within membranes. - hexose transmembrane transport - - - - - The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule. - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. - https://github.com/geneontology/go-ontology/issues/17904 - Wikipedia:Amino_acid_synthesis - amino acid anabolism - amino acid biosynthesis - amino acid formation - amino acid synthesis - cellular amino acid biosynthetic process - biological_process - GO:0008652 - amino acid biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. - ISBN:0198506732 - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. - jl - 2012-10-17T15:52:35Z - GO:0044243 - GO:0044712 - Wikipedia:Catabolism - breakdown - catabolism - degradation - multicellular organismal catabolic process - biological_process - single-organism catabolic process - GO:0009056 - - - - catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. - ISBN:0198547684 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GO:0043285 - GO:0044266 - biopolymer catabolic process - macromolecule breakdown - macromolecule catabolism - macromolecule degradation - multicellular organismal macromolecule catabolic process - biological_process - cellular macromolecule catabolic process - cellular macromolecule catabolism - cellular macromolecule degradation - GO:0009057 - - macromolecule catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:mah - - - - - biopolymer catabolic process - GOC:mtg_chebi_dec09 - - - - - - - - - The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. - jl - 2012-10-17T15:52:18Z - GO:0044274 - GO:0044711 - formation - Wikipedia:Anabolism - anabolism - biosynthesis - synthesis - multicellular organismal biosynthetic process - biological_process - single-organism biosynthetic process - GO:0009058 - - - - biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. - GOC:curators - ISBN:0198547684 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - https://github.com/geneontology/go-ontology/issues/15249 - https://github.com/geneontology/go-ontology/issues/25418 - GO:0043284 - biopolymer biosynthetic process - macromolecule anabolism - macromolecule biosynthesis - macromolecule formation - macromolecule synthesis - biological_process - GO:0009059 - - macromolecule biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:mah - - - - - biopolymer biosynthetic process - GOC:mtg_chebi_dec09 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. - https://github.com/geneontology/go-ontology/issues/17904 - amino acid breakdown - amino acid catabolism - amino acid degradation - cellular amino acid catabolic process - biological_process - GO:0009063 - amino acid catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. - glycoprotein metabolism - biological_process - GO:0009100 - - glycoprotein metabolic process - - - - - The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. - GOC:go_curators - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. - glycoprotein anabolism - glycoprotein biosynthesis - glycoprotein formation - glycoprotein synthesis - biological_process - GO:0009101 - glycoprotein biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. - GOC:go_curators - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine. - nucleobase metabolism - biological_process - GO:0009112 - nucleobase metabolic process - - - - - The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine. - GOC:ma - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. - glucan anabolism - glucan biosynthesis - glucan formation - glucan synthesis - biological_process - GO:0009250 - glucan biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues. - glucan breakdown - glucan catabolism - glucan degradation - biological_process - GO:0009251 - glucan catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The controlled release of proteins from a cell. - GO:0045166 - GO:0045731 - glycoprotein secretion - protein secretion during cell fate commitment - protein secretion resulting in cell fate commitment - biological_process - GO:0009306 - protein secretion - - - - - The controlled release of proteins from a cell. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. - jl - 2009-07-15T11:55:44Z - GO:0044106 - amine metabolism - cellular amine metabolic process - biological_process - GO:0009308 - - - amine metabolic process - - - - - The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. - amine anabolism - amine biosynthesis - amine formation - amine synthesis - biological_process - GO:0009309 - amine biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. - amine breakdown - amine catabolism - amine degradation - biological_process - GO:0009310 - amine catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. - GOC:jl - ISBN:0198506732 - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. - response to electromagnetic radiation stimulus - response to radiation stimulus - biological_process - GO:0009314 - Note that 'radiation' refers to electromagnetic radiation of any wavelength. - response to radiation - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. - GOC:jl - Wikipedia:Electromagnetic_radiation - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. - biological_process - GO:0009416 - - response to light stimulus - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. - GOC:go_curators - ISBN:0582227089 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). - https://github.com/geneontology/go-ontology/issues/20176 - Wikipedia:Fertilisation - syngamy - biological_process - GO:0009566 - fertilization - - - - - The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). - GOC:tb - ISBN:0198506732 - - - - - - - - - - The series of events in which an external stimulus is received by a cell and converted into a molecular signal. - biological_process - perception of external stimulus - GO:0009581 - detection of external stimulus - - - - - The series of events in which an external stimulus is received by a cell and converted into a molecular signal. - GOC:hb - - - - - - - - - - The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. - biological_process - perception of abiotic stimulus - GO:0009582 - detection of abiotic stimulus - - - - - The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. - GOC:hb - - - - - - - - - - - The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. - detection of light - biological_process - perception of light - GO:0009583 - detection of light stimulus - - - - - The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. - GOC:go_curators - - - - - - - - - The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. - biological_process - perception of visible light - GO:0009584 - detection of visible light - - - - - The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. - GOC:go_curators - ISBN:0198506732 - - - - - - - - - - - - - - - The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal. - chemoperception - detection of chemical substance - biological_process - chemoreception - perception of chemical stimulus - perception of chemical substance - GO:0009593 - detection of chemical stimulus - - - - - The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal. - GOC:jl - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. - response to environmental stimulus - biological_process - GO:0009605 - - - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - response to external stimulus - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. - GOC:hb - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. - response to biotic stress - biological_process - GO:0009607 - - - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - response to biotic stimulus - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. - GOC:hb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. - GO:0009618 - GO:0009680 - response to bacteria - biological_process - GO:0009617 - response to bacterium - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. - GOC:hb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. - GO:0009621 - response to fungi - biological_process - GO:0009620 - response to fungus - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. - GOC:hb - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. - https://github.com/geneontology/go-ontology/issues/16572 - response to abiotic stress - biological_process - GO:0009628 - - - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - response to abiotic stimulus - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. - GOC:hb - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. - detoxification response - biological_process - toxin resistance - toxin susceptibility/resistance - GO:0009636 - - response to toxic substance - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. - GOC:lr - - - - - - - - - - - - - - - - - The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. - embryogenesis and morphogenesis - Wikipedia:Morphogenesis - anatomical structure organization - morphogenesis - biological_process - GO:0009653 - anatomical structure morphogenesis - - - - - The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. - GOC:go_curators - ISBN:0521436125 - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. - biological_process - catechol metabolic process - catechol metabolism - GO:0009712 - catechol-containing compound metabolic process - - - - - The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. - GOC:sm - ISBN:0198547684 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. - biological_process - catechol anabolism - catechol biosynthesis - catechol biosynthetic process - catechol formation - catechol synthesis - GO:0009713 - catechol-containing compound biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. - GOC:go_curators - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. - biological_process - GO:0009719 - - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - response to endogenous stimulus - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. - GOC:sm - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. - response to hormone stimulus - biological_process - growth regulator - GO:0009725 - response to hormone - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. - GOC:jl - - - - - response to hormone stimulus - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. - response to carbohydrate stimulus - biological_process - GO:0009743 - response to carbohydrate - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. - GOC:jl - - - - - response to carbohydrate stimulus - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. - response to hexose stimulus - biological_process - GO:0009746 - response to hexose - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. - GOC:jl - - - - - response to hexose stimulus - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. - response to glucose stimulus - biological_process - GO:0009749 - response to glucose - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. - GOC:jl - - - - - response to glucose stimulus - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of asymmetric cell division. - biological_process - GO:0009786 - regulation of asymmetric cell division - - - - - Any process that modulates the frequency, rate or extent of asymmetric cell division. - GOC:lr - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. - GO:0009795 - embryogenesis and morphogenesis - Wikipedia:Embryogenesis - embryogenesis - embryonal development - biological_process - GO:0009790 - - - - embryo development - - - - - The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. - GOC:go_curators - GOC:isa_complete - GOC:mtg_sensu - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. - biological_process - GO:0009791 - - post-embryonic development - - - - - The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. - embryogenesis - biological_process - GO:0009792 - embryo development ending in birth or egg hatching - - - - - The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. - GOC:go_curators - GOC:isa_complete - GOC:mtg_sensu - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). - alkaloid metabolism - biological_process - GO:0009820 - - alkaloid metabolic process - - - - - The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). - GOC:lr - ISBN:0122146743 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases). - UM-BBD_enzymeID:e0711 - alkaloid anabolism - alkaloid biosynthesis - alkaloid formation - alkaloid synthesis - biological_process - GO:0009821 - alkaloid biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases). - GOC:lr - ISBN:0122146743 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). - alkaloid breakdown - alkaloid catabolism - alkaloid degradation - biological_process - GO:0009822 - alkaloid catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). - GOC:lr - ISBN:0122146743 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. - histogenesis and organogenesis - biological_process - GO:0009887 - animal organ morphogenesis - - - - - Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. - GOC:dgh - GOC:go_curators - ISBN:0471245208 - ISBN:0721662544 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. - - - - - - histogenesis and organogenesis - Wikipedia:Histogenesis - histogenesis - biological_process - GO:0009888 - tissue development - - - - - The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. - ISBN:0471245208 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. - regulation of anabolism - regulation of biosynthesis - regulation of formation - regulation of synthesis - biological_process - GO:0009889 - regulation of biosynthetic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. - down regulation of biosynthetic process - down-regulation of biosynthetic process - downregulation of biosynthetic process - negative regulation of anabolism - negative regulation of biosynthesis - negative regulation of formation - negative regulation of synthesis - inhibition of biosynthetic process - biological_process - GO:0009890 - negative regulation of biosynthetic process - - - - - Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. - positive regulation of anabolism - positive regulation of biosynthesis - positive regulation of formation - positive regulation of synthesis - up regulation of biosynthetic process - up-regulation of biosynthetic process - upregulation of biosynthetic process - activation of biosynthetic process - stimulation of biosynthetic process - biological_process - GO:0009891 - positive regulation of biosynthetic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - GO:0044252 - down regulation of metabolic process - down-regulation of metabolic process - downregulation of metabolic process - negative regulation of metabolism - negative regulation of organismal metabolism - inhibition of metabolic process - inhibition of organismal metabolic process - negative regulation of multicellular organismal metabolic process - biological_process - GO:0009892 - negative regulation of metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - GO:0044253 - positive regulation of metabolism - up regulation of metabolic process - up-regulation of metabolic process - upregulation of metabolic process - activation of metabolic process - positive regulation of multicellular organismal metabolic process - positive regulation of organismal metabolism - stimulation of metabolic process - stimulation of organismal metabolic process - up-regulation of organismal metabolic process - biological_process - GO:0009893 - positive regulation of metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. - regulation of breakdown - regulation of catabolism - regulation of degradation - biological_process - GO:0009894 - regulation of catabolic process - - - - - Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. - down regulation of catabolic process - down-regulation of catabolic process - downregulation of catabolic process - negative regulation of breakdown - negative regulation of catabolism - negative regulation of degradation - inhibition of catabolic process - biological_process - GO:0009895 - negative regulation of catabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. - positive regulation of breakdown - positive regulation of catabolism - positive regulation of degradation - up regulation of catabolic process - up-regulation of catabolic process - upregulation of catabolic process - activation of catabolic process - stimulation of catabolic process - biological_process - GO:0009896 - positive regulation of catabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. - GO:0043355 - biological_process - hypodermal cell differentiation - GO:0009913 - epidermal cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. - GOC:dph - GOC:go_curators - GOC:mtg_sensu - GOC:sdb_2009 - GOC:tb - - - - - hypodermal cell differentiation - GOC:kmv - GOC:rk - - - - - - - - - The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0009914 - - hormone transport - - - - - The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:tb - - - - - - - - - The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. - biological_process - anterior/posterior pattern formation - GO:0009952 - anterior/posterior pattern specification - - - - - The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. - GOC:dph - GOC:go_curators - GOC:isa_complete - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of signal transduction. - GO:0035466 - biological_process - regulation of signaling pathway - regulation of signalling pathway - GO:0009966 - regulation of signal transduction - - - - - Any process that modulates the frequency, rate or extent of signal transduction. - GOC:sm - - - - - regulation of signalling pathway - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of signal transduction. - GO:0035468 - up regulation of signal transduction - up-regulation of signal transduction - upregulation of signal transduction - activation of signal transduction - stimulation of signal transduction - biological_process - positive regulation of signaling pathway - positive regulation of signalling pathway - GO:0009967 - positive regulation of signal transduction - - - - - Any process that activates or increases the frequency, rate or extent of signal transduction. - GOC:sm - - - - - positive regulation of signalling pathway - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. - GO:0035467 - down regulation of signal transduction - down-regulation of signal transduction - downregulation of signal transduction - inhibition of signal transduction - biological_process - negative regulation of signaling pathway - negative regulation of signalling pathway - GO:0009968 - negative regulation of signal transduction - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. - GOC:sm - - - - - negative regulation of signalling pathway - GOC:mah - - - - - - - - - Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - jl - 2012-12-11T16:56:55Z - GO:0008151 - GO:0044763 - GO:0050875 - cell physiology - cellular physiological process - cell growth and/or maintenance - biological_process - single-organism cellular process - GO:0009987 - - - This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. - cellular process - - - - - Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GOC:go_curators - GOC:isa_complete - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. - oocyte cell differentiation - biological_process - GO:0009994 - oocyte differentiation - - - - - The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. - GOC:go_curators - GOC:mtg_sensu - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. - GO:0007404 - GO:0043360 - glia cell differentiation - neuroglia differentiation - biological_process - GO:0010001 - glial cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. - GOC:go_curators - GOC:mtg_sensu - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. - cardiac precursor cell differentiation - cardioblast cell differentiation - biological_process - cardiomyocyte generation - GO:0010002 - cardioblast differentiation - - - - - The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. - GOC:go_curators - - - - - cardiac precursor cell differentiation - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - Compaction of chromatin structure prior to meiosis in eukaryotic cells. - chromosome condensation involved in meiotic cell cycle - biological_process - GO:0010032 - meiotic chromosome condensation - - - - - Compaction of chromatin structure prior to meiosis in eukaryotic cells. - PMID:10072401 - - - - - chromosome condensation involved in meiotic cell cycle - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. - GO:1990367 - process resulting in tolerance to organic substance - biological_process - GO:0010033 - response to organic substance - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. - GOC:sm - PMID:23356676 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus. - biological_process - GO:0010034 - response to acetate - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus. - GOC:sm - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. - biological_process - GO:0010035 - response to inorganic substance - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. - GOC:sm - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. - response to metal - response to heavy metal - biological_process - heavy metal sensitivity/resistance - GO:0010038 - response to metal ion - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. - GOC:sm - - - - - - - - - - - - - - - - - - - - - - - - - - The division of the zygote into two daughter cells that will adopt developmentally distinct potentials. - biological_process - zygote asymmetric cytokinesis - GO:0010070 - zygote asymmetric cell division - - - - - The division of the zygote into two daughter cells that will adopt developmentally distinct potentials. - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues. - GO:0048862 - organ boundary specification - biological_process - GO:0010160 - formation of animal organ boundary - - - - - The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues. - GOC:dph - GOC:isa_complete - PMID:9611175 - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the soma are generated and organized. - biological_process - GO:0010171 - body morphogenesis - - - - - The process in which the anatomical structures of the soma are generated and organized. - GOC:ems - ISBN:0140512888 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. - response to organic nitrogen - biological_process - GO:0010243 - response to organonitrogen compound - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. - PMID:9869419 - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. - endomembrane organization - endomembrane system organisation - biological_process - GO:0010256 - - endomembrane system organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. - GOC:mah - GOC:sm - - - - - endomembrane system organisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. - biological_process - GO:0010453 - regulation of cell fate commitment - - - - - Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. - biological_process - GO:0010454 - negative regulation of cell fate commitment - - - - - Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. - biological_process - GO:0010455 - positive regulation of cell fate commitment - - - - - Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. - biological_process - GO:0010463 - mesenchymal cell proliferation - - - - - The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. - biological_process - GO:0010464 - regulation of mesenchymal cell proliferation - - - - - Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. - GOC:dph - GOC:tb - - - - - - - - - The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. - https://github.com/geneontology/go-ontology/issues/22557 - https://github.com/geneontology/go-ontology/issues/25419 - Wikipedia:Gene_expression - biological_process - GO:0010467 - - gene expression - - - - - The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. - GOC:txnOH-2018 - PMID:25934543 - PMID:31580950 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). - https://github.com/geneontology/go-ontology/issues/22557 - Wikipedia:Regulation_of_gene_expression - regulation of protein expression - biological_process - gene regulation - regulation of gene product expression - GO:0010468 - This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation. - regulation of gene expression - - - - - Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). - GOC:txnOH-2018 - - - - - gene regulation - GOC:cjm - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. - biological_process - GO:0010470 - regulation of gastrulation - - - - - Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells. - biological_process - hypodermal cell division - GO:0010481 - epidermal cell division - - - - - Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells. - PMID:17450124 - - - - - hypodermal cell division - GOC:kmv - GOC:rk - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis. - biological_process - regulation of hypodermal cell division - GO:0010482 - regulation of epidermal cell division - - - - - Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis. - PMID:17450124 - - - - - regulation of hypodermal cell division - GOC:kmv - GOC:rk - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The movement of substances between cells. - jl - 2013-12-19T13:24:56Z - GO:1902585 - biological_process - single organism intercellular transport - single-organism intercellular transport - GO:0010496 - intercellular transport - - - - - The movement of substances between cells. - GOC:dhl - - - - - single organism intercellular transport - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of membrane disassembly. - biological_process - GO:0010549 - regulation of membrane disassembly - - - - - Any process that modulates the frequency, rate or extent of membrane disassembly. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - biological_process - GO:0010556 - regulation of macromolecule biosynthetic process - - - - - Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - biological_process - GO:0010557 - positive regulation of macromolecule biosynthetic process - - - - - Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - biological_process - GO:0010558 - negative regulation of macromolecule biosynthetic process - - - - - Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. - biological_process - GO:0010559 - regulation of glycoprotein biosynthetic process - - - - - Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. - biological_process - GO:0010560 - positive regulation of glycoprotein biosynthetic process - - - - - Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. - biological_process - GO:0010561 - negative regulation of glycoprotein biosynthetic process - - - - - Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. - biological_process - GO:0010562 - positive regulation of phosphorus metabolic process - - - - - Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. - biological_process - GO:0010563 - negative regulation of phosphorus metabolic process - - - - - Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. - biological_process - GO:0010564 - regulation of cell cycle process - - - - - Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. - biological_process - GO:0010565 - regulation of cellular ketone metabolic process - - - - - Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells. - biological_process - GO:0010566 - regulation of ketone biosynthetic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells. - biological_process - GO:0010567 - regulation of ketone catabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - biological_process - GO:0010604 - positive regulation of macromolecule metabolic process - - - - - Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - biological_process - GO:0010605 - negative regulation of macromolecule metabolic process - - - - - Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:dph - GOC:tb - - - - - - - - - Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. - posttranscriptional regulation of gene expression - biological_process - GO:0010608 - post-transcriptional regulation of gene expression - - - - - Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. - biological_process - GO:0010611 - regulation of cardiac muscle hypertrophy - - - - - Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. - biological_process - GO:0010612 - regulation of cardiac muscle adaptation - - - - - Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. - biological_process - GO:0010613 - positive regulation of cardiac muscle hypertrophy - - - - - Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. - GOC:BHF - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. - biological_process - GO:0010614 - negative regulation of cardiac muscle hypertrophy - - - - - Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. - GOC:BHF - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. - biological_process - GO:0010615 - positive regulation of cardiac muscle adaptation - - - - - Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. - GOC:BHF - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. - biological_process - GO:0010616 - negative regulation of cardiac muscle adaptation - - - - - Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. - GOC:BHF - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - The activation of endogenous cellular processes that result in the death of a cell as part of its development. - developmental programmed cell death - programmed cell death involved in development - biological_process - GO:0010623 - This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure. - programmed cell death involved in cell development - - - - - The activation of endogenous cellular processes that result in the death of a cell as part of its development. - GOC:dph - GOC:mtg_apoptosis - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). - https://github.com/geneontology/go-ontology/issues/22557 - biological_process - GO:0010628 - positive regulation of gene expression - - - - - Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). - GOC:txnOH-2018 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). - https://github.com/geneontology/go-ontology/issues/22557 - biological_process - gene silencing - GO:0010629 - This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. - negative regulation of gene expression - - - - - Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). - GOC:txnOH-2018 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. - positive regulation of organelle organisation - biological_process - positive regulation of organelle organization and biogenesis - GO:0010638 - positive regulation of organelle organization - - - - - Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. - GOC:dph - GOC:tb - - - - - positive regulation of organelle organisation - GOC:mah - - - - - positive regulation of organelle organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. - negative regulation of organelle organisation - biological_process - negative regulation of organelle organization and biogenesis - GO:0010639 - negative regulation of organelle organization - - - - - Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. - GOC:dph - GOC:tb - - - - - negative regulation of organelle organisation - GOC:mah - - - - - negative regulation of organelle organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - biological_process - GO:0010646 - regulation of cell communication - - - - - Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - biological_process - GO:0010647 - positive regulation of cell communication - - - - - Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - biological_process - GO:0010648 - negative regulation of cell communication - - - - - Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. - negative regulation of muscle cell apoptosis - biological_process - GO:0010656 - negative regulation of muscle cell apoptotic process - - - - - Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. - GOC:dph - GOC:mtg_apoptosis - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle. - muscle cell apoptosis - biological_process - GO:0010657 - muscle cell apoptotic process - - - - - A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle. - CL:0000187 - GOC:dph - GOC:mtg_apoptosis - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations. - striated muscle cell apoptosis - biological_process - GO:0010658 - striated muscle cell apoptotic process - - - - - A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations. - CL:0000737 - GOC:dph - GOC:mtg_apoptosis - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. - cardiac muscle cell apoptosis - biological_process - GO:0010659 - cardiac muscle cell apoptotic process - - - - - A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. - CL:0000746 - GOC:dph - GOC:mtg_apoptosis - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. - regulation of muscle cell apoptosis - biological_process - GO:0010660 - regulation of muscle cell apoptotic process - - - - - Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. - GOC:dph - GOC:mtg_apoptosis - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. - positive regulation of muscle cell apoptosis - biological_process - GO:0010661 - positive regulation of muscle cell apoptotic process - - - - - Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. - GOC:dph - GOC:mtg_apoptosis - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. - regulation of striated muscle cell apoptosis - biological_process - GO:0010662 - regulation of striated muscle cell apoptotic process - - - - - Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. - GOC:dph - GOC:mtg_apoptosis - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. - positive regulation of striated muscle cell apoptosis - biological_process - GO:0010663 - positive regulation of striated muscle cell apoptotic process - - - - - Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. - GOC:dph - GOC:mtg_apoptosis - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. - down regulation of striated muscle cell apoptosis - down-regulation of striated muscle cell apoptosis - downregulation of striated muscle cell apoptosis - inhibition of striated muscle cell apoptosis - negative regulation of striated muscle cell apoptosis - biological_process - GO:0010664 - negative regulation of striated muscle cell apoptotic process - - - - - Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. - GOC:BHF - GOC:dph - GOC:mtg_apoptosis - GOC:rl - GOC:tb - - - - - down regulation of striated muscle cell apoptosis - GOC:dph - GOC:rl - GOC:tb - - - - - down-regulation of striated muscle cell apoptosis - GOC:dph - GOC:rl - GOC:tb - - - - - downregulation of striated muscle cell apoptosis - GOC:dph - GOC:rl - GOC:tb - - - - - inhibition of striated muscle cell apoptosis - GOC:dph - GOC:rl - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. - regulation of cardiac muscle cell apoptosis - biological_process - GO:0010665 - regulation of cardiac muscle cell apoptotic process - - - - - Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. - GOC:dph - GOC:mtg_apoptosis - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. - positive regulation of cardiac muscle cell apoptosis - biological_process - GO:0010666 - positive regulation of cardiac muscle cell apoptotic process - - - - - Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. - GOC:dph - GOC:mtg_apoptosis - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. - down regulation of cardiac muscle cell apoptosis - down-regulation of cardiac muscle cell apoptosis - downregulation of cardiac muscle cell apoptosis - inhibition of cardiac muscle cell apoptosis - negative regulation of cardiac muscle cell apoptosis - biological_process - GO:0010667 - negative regulation of cardiac muscle cell apoptotic process - - - - - Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. - GOC:BHF - GOC:dph - GOC:mtg_apoptosis - GOC:rl - GOC:tb - - - - - down regulation of cardiac muscle cell apoptosis - GOC:dph - GOC:rl - GOC:tb - - - - - down-regulation of cardiac muscle cell apoptosis - GOC:dph - GOC:rl - GOC:tb - - - - - downregulation of cardiac muscle cell apoptosis - GOC:dph - GOC:rl - GOC:tb - - - - - inhibition of cardiac muscle cell apoptosis - GOC:dph - GOC:rl - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate. - biological_process - GO:0010668 - ectodermal cell differentiation - - - - - The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine. - biological_process - GO:0010700 - negative regulation of norepinephrine secretion - - - - - Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. - biological_process - GO:0010701 - positive regulation of norepinephrine secretion - - - - - Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. - regulation of collagen breakdown - regulation of collagen catabolism - regulation of collagen degradation - biological_process - GO:0010710 - regulation of collagen catabolic process - - - - - Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. - GOC:BHF - GOC:dph - GOC:tb - - - - - regulation of collagen breakdown - GOC:dph - GOC:tb - - - - - regulation of collagen catabolism - GOC:dph - GOC:tb - - - - - regulation of collagen degradation - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. - down regulation of collagen catabolic process - down-regulation of collagen catabolic process - downregulation of collagen catabolic process - negative regulation of collagen breakdown - negative regulation of collagen catabolism - negative regulation of collagen degradation - inhibition of collagen catabolic process - biological_process - GO:0010711 - negative regulation of collagen catabolic process - - - - - Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. - GOC:BHF - GOC:dph - GOC:tb - - - - - down regulation of collagen catabolic process - GOC:dph - GOC:tb - - - - - down-regulation of collagen catabolic process - GOC:dph - GOC:tb - - - - - downregulation of collagen catabolic process - GOC:dph - GOC:tb - - - - - negative regulation of collagen breakdown - GOC:dph - GOC:tb - - - - - negative regulation of collagen catabolism - GOC:dph - GOC:tb - - - - - negative regulation of collagen degradation - GOC:dph - GOC:tb - - - - - inhibition of collagen catabolic process - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. - regulation of collagen metabolism - biological_process - GO:0010712 - regulation of collagen metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. - GOC:dph - GOC:tb - - - - - regulation of collagen metabolism - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. - biological_process - GO:0010713 - negative regulation of collagen metabolic process - - - - - Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. - positive regulation of collagen metabolism - biological_process - GO:0010714 - positive regulation of collagen metabolic process - - - - - Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. - GOC:dph - GOC:tb - - - - - positive regulation of collagen metabolism - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. - regulation of extracellular matrix breakdown - regulation of extracellular matrix degradation - biological_process - GO:0010715 - regulation of extracellular matrix disassembly - - - - - Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. - GOC:BHF - GOC:dph - GOC:tb - - - - - regulation of extracellular matrix breakdown - GOC:dph - GOC:tb - - - - - regulation of extracellular matrix degradation - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. - down regulation of extracellular matrix disassembly - down-regulation of extracellular matrix disassembly - downregulation of extracellular matrix disassembly - negative regulation of extracellular matrix breakdown - negative regulation of extracellular matrix degradation - inhibition of extracellular matrix disassembly - biological_process - GO:0010716 - negative regulation of extracellular matrix disassembly - - - - - Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. - GOC:BHF - GOC:dph - GOC:tb - - - - - down regulation of extracellular matrix disassembly - GOC:dph - GOC:tb - - - - - down-regulation of extracellular matrix disassembly - GOC:dph - GOC:tb - - - - - downregulation of extracellular matrix disassembly - GOC:dph - GOC:tb - - - - - negative regulation of extracellular matrix breakdown - GOC:dph - GOC:tb - - - - - negative regulation of extracellular matrix degradation - GOC:dph - GOC:tb - - - - - inhibition of extracellular matrix disassembly - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. - biological_process - GO:0010717 - regulation of epithelial to mesenchymal transition - - - - - Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. - GOC:BHF - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. - biological_process - GO:0010718 - positive regulation of epithelial to mesenchymal transition - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. - GOC:BHF - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. - biological_process - GO:0010719 - negative regulation of epithelial to mesenchymal transition - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. - GOC:BHF - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. - biological_process - GO:0010720 - positive regulation of cell development - - - - - Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. - GOC:BHF - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. - biological_process - GO:0010721 - negative regulation of cell development - - - - - Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. - GOC:BHF - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0010765 - positive regulation of sodium ion transport - - - - - Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0010766 - negative regulation of sodium ion transport - - - - - Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. - https://github.com/geneontology/go-ontology/issues/24299 - biological_process - GO:0010770 - positive regulation of cell morphogenesis - - - - - Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. - https://github.com/geneontology/go-ontology/issues/24299 - biological_process - GO:0010771 - negative regulation of cell morphogenesis - - - - - Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - regulation of glucose transport - GO:0010827 - regulation of glucose transmembrane transport - - - - - Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - positive regulation of glucose transport - GO:0010828 - positive regulation of glucose transmembrane transport - - - - - Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:BHF - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - negative regulation of glucose transport - GO:0010829 - negative regulation of glucose transmembrane transport - - - - - Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:BHF - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. - biological_process - GO:0010830 - regulation of myotube differentiation - - - - - Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. - biological_process - GO:0010831 - positive regulation of myotube differentiation - - - - - Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. - biological_process - GO:0010832 - negative regulation of myotube differentiation - - - - - Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. - retinal lamination - retinal layer formation - biological_process - GO:0010842 - retina layer formation - - - - - The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. - GOC:ascb_2009 - GOC:dph - GOC:tb - PMID:1270266 - - - - - retinal lamination - GOC:dph - GOC:tb - - - - - retinal layer formation - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a lipid is transported to, or maintained in, a specific location. - lipid localisation - biological_process - GO:0010876 - lipid localization - - - - - Any process in which a lipid is transported to, or maintained in, a specific location. - GOC:BHF - GOC:dph - GOC:tb - - - - - lipid localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. - biological_process - GO:0010893 - positive regulation of steroid biosynthetic process - - - - - Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. - biological_process - GO:0010894 - negative regulation of steroid biosynthetic process - - - - - Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. - GOC:BHF - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. - regulation of glucose metabolism - biological_process - GO:0010906 - regulation of glucose metabolic process - - - - - Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. - GOC:BHF - GOC:tb - - - - - regulation of glucose metabolism - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. - positive regulation of glucose metabolism - biological_process - GO:0010907 - positive regulation of glucose metabolic process - - - - - Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. - GOC:BHF - GOC:tb - - - - - positive regulation of glucose metabolism - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The cellular component assembly that is part of the initial shaping of the component during its developmental progression. - biological_process - GO:0010927 - cellular component assembly involved in morphogenesis - - - - - The cellular component assembly that is part of the initial shaping of the component during its developmental progression. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization. - biological_process - GO:0010937 - regulation of cytoplasmic microtubule depolymerization - - - - - Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule. - biological_process - GO:0010938 - cytoplasmic microtubule depolymerization - - - - - The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. - tb - 2009-04-27T09:53:22Z - biological_process - GO:0010948 - negative regulation of cell cycle process - - - - - Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - tb - 2009-05-06T11:40:55Z - biological_process - GO:0010959 - regulation of metal ion transport - - - - - Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. - tb - 2009-05-11T12:17:53Z - biological_process - GO:0010962 - regulation of glucan biosynthetic process - - - - - Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - tb - 2009-05-20T11:42:50Z - biological_process - GO:0010966 - regulation of phosphate transport - - - - - Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. - tb - 2009-05-20T11:51:21Z - biological_process - GO:0010968 - regulation of microtubule nucleation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity. - tb - 2009-05-27T10:56:08Z - microtubule-based transport - establishment of localization by movement along microtubule - movement along microtubule - biological_process - GO:0010970 - transport along microtubule - - - - - The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity. - GOC:dph - GOC:mah - GOC:tb - - - - - establishment of localization by movement along microtubule - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). - tb - 2009-06-01T10:44:45Z - regulation of neurite biosynthesis - regulation of neurite development - regulation of neurite formation - regulation of neurite growth - biological_process - GO:0010975 - regulation of neuron projection development - - - - - Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). - GOC:dph - GOC:tb - - - - - regulation of neurite biosynthesis - GOC:mah - - - - - regulation of neurite development - GOC:mah - - - - - regulation of neurite formation - GOC:mah - - - - - regulation of neurite growth - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). - tb - 2009-06-01T10:46:44Z - positive regulation of neurite biosynthesis - positive regulation of neurite development - positive regulation of neurite formation - positive regulation of neurite growth - biological_process - GO:0010976 - positive regulation of neuron projection development - - - - - Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). - GOC:dph - GOC:tb - - - - - positive regulation of neurite biosynthesis - GOC:mah - - - - - positive regulation of neurite development - GOC:mah - - - - - positive regulation of neurite formation - GOC:mah - - - - - positive regulation of neurite growth - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). - tb - 2009-06-01T10:47:42Z - negative regulation of neurite biosynthesis - negative regulation of neurite development - negative regulation of neurite formation - negative regulation of neurite growth - biological_process - growth cone collapse - GO:0010977 - negative regulation of neuron projection development - - - - - Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). - GOC:dph - GOC:tb - - - - - negative regulation of neurite biosynthesis - GOC:mah - - - - - negative regulation of neurite development - GOC:mah - - - - - negative regulation of neurite formation - GOC:mah - - - - - negative regulation of neurite growth - GOC:mah - - - - - growth cone collapse - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. - https://github.com/geneontology/go-ontology/issues/24835 - GO:0016244 - regulated cell death - Wikipedia:Programmed_cell_death - caspase-independent cell death - non-apoptotic programmed cell death - nonapoptotic programmed cell death - biological_process - PCD - RCD - caspase-independent apoptosis - GO:0012501 - - - - - - - - Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children. - programmed cell death - - - - - A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. - GOC:lr - GOC:mtg_apoptosis - - - - - - - - - - - - - - - - - - - - - - - - - - - A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. - Wikipedia:Endomembrane_system - cellular_component - GO:0012505 - - - - endomembrane system - - - - - A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. - GOC:lh - - - - - - - - - - - - - - - - - - - - - - - - - - The lipid bilayer surrounding any membrane-bounded vesicle in the cell. - NIF_Subcellular:sao1153182838 - cellular_component - GO:0012506 - vesicle membrane - - - - - The lipid bilayer surrounding any membrane-bounded vesicle in the cell. - GOC:mah - GOC:vesicle - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others. - glia proliferation - biological_process - GO:0014009 - glial cell proliferation - - - - - The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others. - GOC:ef - ISBN:0878932585 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. - biological_process - GO:0014013 - regulation of gliogenesis - - - - - Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. - down regulation of gliogenesis - down-regulation of gliogenesis - downregulation of gliogenesis - inhibition of gliogenesis - biological_process - GO:0014014 - negative regulation of gliogenesis - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. - up regulation of gliogenesis - up-regulation of gliogenesis - upregulation of gliogenesis - activation of gliogenesis - stimulation of gliogenesis - biological_process - GO:0014015 - positive regulation of gliogenesis - - - - - Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts. - biological_process - GO:0014016 - neuroblast differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts. - GOC:ef - ISBN:0878932585 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron. - biological_process - GO:0014019 - neuroblast development - - - - - The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron. - GOC:ef - ISBN:0878932585 - - - - - - - - - - - - - - - The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube. - GO:0014024 - primary neural tube morphogenesis - primary neurulation - biological_process - neural rod cavitation - GO:0014020 - primary neural tube formation - - - - - The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube. - GOC:ef - ISBN:0878932585 - PMID:15327780 - - - - - primary neural tube morphogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts. - biological_process - GO:0014023 - neural rod formation - - - - - The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts. - GOC:dh - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts. - biological_process - GO:0014025 - neural keel formation - - - - - The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts. - GOC:dh - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column. - biological_process - GO:0014028 - notochord formation - - - - - The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column. - GOC:dh - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. - biological_process - GO:0014029 - neural crest formation - - - - - The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. - GOC:dh - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. - biological_process - GO:0014031 - mesenchymal cell development - - - - - The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. - GOC:dh - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. - biological_process - GO:0014032 - neural crest cell development - - - - - The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. - GOC:dh - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. - biological_process - GO:0014033 - neural crest cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. - GOC:dh - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change. - biological_process - GO:0014041 - regulation of neuron maturation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change. - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of neuron maturation. - up regulation of neuron maturation - up-regulation of neuron maturation - upregulation of neuron maturation - activation of neuron maturation - stimulation of neuron maturation - biological_process - GO:0014042 - positive regulation of neuron maturation - - - - - Any process that activates or increases the frequency, rate or extent of neuron maturation. - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation. - down regulation of neuron maturation - down-regulation of neuron maturation - downregulation of neuron maturation - inhibition of neuron maturation - biological_process - GO:0014043 - negative regulation of neuron maturation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation. - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS). - biological_process - GO:0014055 - acetylcholine secretion, neurotransmission - - - - - The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS). - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine. - biological_process - GO:0014056 - regulation of acetylcholine secretion, neurotransmission - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine. - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine. - up regulation of acetylcholine secretion - up-regulation of acetylcholine secretion - upregulation of acetylcholine secretion - activation of acetylcholine secretion - stimulation of acetylcholine secretion - biological_process - GO:0014057 - positive regulation of acetylcholine secretion, neurotransmission - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine. - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine. - down regulation of acetylcholine secretion - down-regulation of acetylcholine secretion - downregulation of acetylcholine secretion - inhibition of acetylcholine secretion - biological_process - GO:0014058 - negative regulation of acetylcholine secretion, neurotransmission - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine. - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. - regulation of noradrenaline secretion - biological_process - GO:0014061 - regulation of norepinephrine secretion - - - - - Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the regulated release of serotonin. - biological_process - regulation of serotonin release - GO:0014062 - regulation of serotonin secretion - - - - - Any process that modulates the frequency, rate or extent of the regulated release of serotonin. - GOC:ef - - - - - regulation of serotonin release - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. - down regulation of serotonin secretion - down-regulation of serotonin secretion - downregulation of serotonin secretion - inhibition of serotonin secretion - biological_process - positive regulation of serotonin release - GO:0014063 - negative regulation of serotonin secretion - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. - GOC:ef - - - - - positive regulation of serotonin release - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin. - up regulation of serotonin secretion - up-regulation of serotonin secretion - upregulation of serotonin secretion - activation of serotonin secretion - stimulation of serotonin secretion - biological_process - positive regulation of serotonin release - GO:0014064 - positive regulation of serotonin secretion - - - - - Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin. - GOC:ef - - - - - positive regulation of serotonin release - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. - response to organic cyclic substance - biological_process - GO:0014070 - response to organic cyclic compound - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. - GOC:ef - - - - - response to organic cyclic substance - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. - response to amine stimulus - biological_process - GO:0014075 - response to amine - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. - GOC:ef - - - - - response to amine stimulus - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells. - biological_process - GO:0014706 - striated muscle tissue development - - - - - The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells. - CL:0000737 - GOC:dph - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. - biological_process - regulation of skeletal muscle plasticity - GO:0014733 - regulation of skeletal muscle adaptation - - - - - Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. - biological_process - GO:0014734 - skeletal muscle hypertrophy - - - - - The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. - biological_process - GO:0014741 - negative regulation of muscle hypertrophy - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of muscle hypertrophy. - biological_process - GO:0014742 - positive regulation of muscle hypertrophy - - - - - Any process that activates or increases the frequency, rate or extent of muscle hypertrophy. - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of muscle hypertrophy. - biological_process - GO:0014743 - regulation of muscle hypertrophy - - - - - Any process that modulates the frequency, rate or extent of muscle hypertrophy. - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of muscle adaptation. - biological_process - positive regulation of muscle plasticity - GO:0014744 - positive regulation of muscle adaptation - - - - - Any process that activates or increases the frequency, rate or extent of muscle adaptation. - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation. - biological_process - negative regulation of muscle plasticity - GO:0014745 - negative regulation of muscle adaptation - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation. - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. - biological_process - smooth muscle plasticity - GO:0014805 - smooth muscle adaptation - - - - - Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of somitogenesis. - biological_process - GO:0014807 - regulation of somitogenesis - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of somitogenesis. - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle contraction. - biological_process - GO:0014819 - regulation of skeletal muscle contraction - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle contraction. - GOC:ef - GOC:mtg_muscle - - - - - - - - - A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. - biological_process - GO:0014821 - phasic smooth muscle contraction - - - - - A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. - GOC:mtg_muscle - - - - - - - - - - A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine. - biological_process - GO:0014827 - intestine smooth muscle contraction - - - - - A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine. - GOC:mtg_muscle - MA:0001539 - MSH:D007422 - - - - - - - - - A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract). - biological_process - GO:0014831 - gastro-intestinal system smooth muscle contraction - - - - - A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract). - GOC:mtg_muscle - MA:0001523 - MSH:D041981 - - - - - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system. - biological_process - GO:0014852 - regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system. - GOC:ef - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. - biological_process - GO:0014855 - striated muscle cell proliferation - - - - - The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. - CL:0000737 - GOC:ef - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population. - biological_process - GO:0014856 - skeletal muscle cell proliferation - - - - - The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population. - CL:0000188 - GOC:ef - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation. - biological_process - GO:0014857 - regulation of skeletal muscle cell proliferation - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation. - CL:0000188 - GOC:ef - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation. - biological_process - GO:0014858 - positive regulation of skeletal muscle cell proliferation - - - - - Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation. - CL:0000188 - GOC:ef - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation. - biological_process - GO:0014859 - negative regulation of skeletal muscle cell proliferation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation. - CL:0000188 - GOC:ef - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. - neurotransmitter secretion involved in control of skeletal muscle contraction - biological_process - GO:0014860 - neurotransmitter secretion involved in regulation of skeletal muscle contraction - - - - - The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. - GOC:dph - GOC:mtg_muscle - GOC:tb - - - - - neurotransmitter secretion involved in control of skeletal muscle contraction - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes. - biological_process - regulation of skeletal muscle contraction via membrane action potential - GO:0014861 - regulation of skeletal muscle contraction via regulation of action potential - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells. - biological_process - GO:0014866 - skeletal myofibril assembly - - - - - The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells. - GOC:ef - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. - biological_process - GO:0014872 - myoblast division - - - - - The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. - CL:0000056 - GOC:ef - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. - biological_process - response to stimulus involved in regulation of muscle plasticity - GO:0014874 - response to stimulus involved in regulation of muscle adaptation - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. - GOC:ef - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation. - biological_process - response to electrical stimulus involved in regulation of muscle plasticity - GO:0014878 - response to electrical stimulus involved in regulation of muscle adaptation - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation. - GOC:ef - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation. - biological_process - GO:0014879 - detection of electrical stimulus involved in regulation of muscle adaptation - - - - - The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation. - GOC:ef - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. - biological_process - cardiac muscle plasticity - GO:0014887 - cardiac muscle adaptation - - - - - The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. - biological_process - striated muscle plasticity - GO:0014888 - striated muscle adaptation - - - - - Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy. - biological_process - GO:0014895 - smooth muscle hypertrophy - - - - - The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy. - GOC:mtg_muscle - - - - - - - - - - - - - - - The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. - Wikipedia:Muscle_hypertrophy - biological_process - GO:0014896 - muscle hypertrophy - - - - - The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. - biological_process - GO:0014897 - striated muscle hypertrophy - - - - - The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. - biological_process - GO:0014902 - myotube differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. - biological_process - GO:0014904 - myotube cell development - - - - - The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GO:0015831 - enzyme transport - biological_process - GO:0015031 - - - - protein transport - - - - - The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of an ion from one side of a membrane to the other. - https://github.com/geneontology/go-ontology/issues/24479 - ion transmembrane transporter activity - ion transporter activity - molecular_function - GO:0015075 - monoatomic ion transmembrane transporter activity - - - - - - - - - - - GO_REF:0000090 - - - - - Enables the transfer of an ion from one side of a membrane to the other. - GOC:dgf - GOC:mtg_transport - ISBN:0815340729 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. - https://github.com/geneontology/go-ontology/issues/24076 - GO:0022816 - RHEA:34963 - sodium transporter activity - molecular_function - GO:0015081 - sodium ion transmembrane transporter activity - - - - - Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. - GOC:BHF - GOC:ai - RHEA:34963 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. - Reactome:R-HSA-2161500 - Reactome:R-HSA-549129 - Reactome:R-HSA-549279 - Reactome:R-HSA-549304 - Reactome:R-HSA-549322 - Reactome:R-HSA-561054 - Reactome:R-HSA-561072 - Reactome:R-HSA-9794270 - Reactome:R-HSA-9794523 - Reactome:R-HSA-9795207 - molecular_function - GO:0015101 - organic cation transmembrane transporter activity - - - - - Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. - GOC:ai - GOC:mtg_transport - ISBN:0815340729 - - - - - Reactome:R-HSA-2161500 - abacavir [extracellular] => abacavir [cytosol] - - - - - Reactome:R-HSA-549129 - OCT1 transports organic cations into hepatic cells - - - - - Reactome:R-HSA-549279 - OCT2 mediates tubular uptake of organic cations in the kidney - - - - - Reactome:R-HSA-549304 - OCT3 mediates renal clearance of organic cations - - - - - Reactome:R-HSA-549322 - OCT1 transports organic cations out of hepatic cells - - - - - Reactome:R-HSA-561054 - OCT2 mediates tubular secretion of organic cations in the kidney - - - - - Reactome:R-HSA-561072 - OCT3 mediates renal uptake of organic cations - - - - - Reactome:R-HSA-9794270 - SLCO1A2 transports Cipro(1+) into the cytosol - - - - - Reactome:R-HSA-9794523 - SLC22A1 transports Cipro into renal cell - - - - - Reactome:R-HSA-9795207 - SLC22A1 transports Cipro into hepatic cell - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. - molecular_function - GO:0015103 - inorganic anion transmembrane transporter activity - - - - - Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. - RHEA:28695 - Reactome:R-HSA-2752067 - molecular_function - GO:0015106 - bicarbonate transmembrane transporter activity - - - - - Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. - GOC:ai - - - - - Reactome:R-HSA-2752067 - BESTs transport cytosolic HCO3- to extracellular region - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other. - pr - 2012-11-22T15:43:10Z - GO:1901677 - RHEA:32823 - molecular_function - phosphate transmembrane transporter activity - GO:0015114 - phosphate ion transmembrane transporter activity - - - - - - - - - - - GO_REF:0000090 - - - - - Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other. - GOC:ai - - - - - phosphate transmembrane transporter activity - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. - RHEA:34983 - Reactome:R-HSA-3560789 - Reactome:R-HSA-427555 - Reactome:R-HSA-8875871 - sulphate transporter activity - molecular_function - sulfate permease activity - GO:0015116 - sulfate transmembrane transporter activity - - - - - - - - - - - GO_REF:0000090 - - - - - Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. - GOC:ai - - - - - Reactome:R-HSA-3560789 - Defective SLC26A2 does not cotransport extracellular SO4(2-), H+ to cytosol - - - - - Reactome:R-HSA-427555 - SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol - - - - - Reactome:R-HSA-8875871 - SLC26A11 transports SO4(2-) from extracellular region to cytosol - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid. - molecular_function - GO:0015123 - acetate transmembrane transporter activity - - - - - - - - - - - GO_REF:0000090 - - - - - Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. - Reactome:R-HSA-194079 - Reactome:R-HSA-194083 - Reactome:R-HSA-194130 - Reactome:R-HSA-5661184 - Reactome:R-HSA-5661198 - Reactome:R-HSA-9733964 - molecular_function - GO:0015125 - bile acid transmembrane transporter activity - - - - - Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. - GOC:ai - - - - - Reactome:R-HSA-194079 - SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol - - - - - Reactome:R-HSA-194083 - SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol - - - - - Reactome:R-HSA-194130 - Transport (influx) of bile salts and acids by OATP-A - - - - - Reactome:R-HSA-5661184 - Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) - - - - - Reactome:R-HSA-5661198 - Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) - - - - - Reactome:R-HSA-9733964 - SLC51A:SLC51B transports bile salts from cytosol to extracellular region - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile. - Reactome:R-HSA-5679031 - Reactome:R-HSA-5679041 - Reactome:R-HSA-9661417 - molecular_function - GO:0015127 - bilirubin transmembrane transporter activity - - - - - Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile. - GOC:ai - ISBN:0198547684 - - - - - Reactome:R-HSA-5679031 - Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region - - - - - Reactome:R-HSA-5679041 - ABCC2 transports BMG,BDG from cytosol to extracellular region - - - - - Reactome:R-HSA-9661417 - ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of carbohydrate from one side of a membrane to the other. - GO:1901476 - sugar transporter - molecular_function - carbohydrate transporter activity - GO:0015144 - carbohydrate transmembrane transporter activity - - - - - - - - - - - GO_REF:0000090 - - - - - Enables the transfer of carbohydrate from one side of a membrane to the other. - GOC:jl - GOC:mtg_transport - ISBN:0815340729 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of a monosaccharide from one side of a membrane to the other. - molecular_function - GO:0015145 - monosaccharide transmembrane transporter activity - - - - - Enables the transfer of a monosaccharide from one side of a membrane to the other. - GOC:jl - GOC:mtg_transport - ISBN:0815340729 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other. - Reactome:R-HSA-189242 - Reactome:R-HSA-5638222 - molecular_function - GO:0015149 - hexose transmembrane transporter activity - - - - - - - - - - - GO_REF:0000090 - - - - - Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other. - GOC:ai - GOC:mtg_transport - ISBN:0815340729 - - - - - Reactome:R-HSA-189242 - SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region - - - - - Reactome:R-HSA-5638222 - Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. - molecular_function - GO:0015159 - polysaccharide transmembrane transporter activity - - - - - Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. - GOC:ai - GOC:mtg_transport - ISBN:0815340729 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. - GO:0015359 - amino acid transporter activity - Reactome:R-HSA-210439 - Reactome:R-HSA-212642 - Reactome:R-HSA-351963 - Reactome:R-HSA-351987 - Reactome:R-HSA-352029 - Reactome:R-HSA-352052 - Reactome:R-HSA-352059 - Reactome:R-HSA-352103 - Reactome:R-HSA-352107 - Reactome:R-HSA-352108 - Reactome:R-HSA-352119 - Reactome:R-HSA-352136 - Reactome:R-HSA-352158 - Reactome:R-HSA-352174 - Reactome:R-HSA-352182 - Reactome:R-HSA-352191 - Reactome:R-HSA-352232 - Reactome:R-HSA-352347 - Reactome:R-HSA-352354 - Reactome:R-HSA-352364 - Reactome:R-HSA-352371 - Reactome:R-HSA-352379 - Reactome:R-HSA-352385 - Reactome:R-HSA-375405 - Reactome:R-HSA-375417 - Reactome:R-HSA-375473 - Reactome:R-HSA-375487 - Reactome:R-HSA-375768 - Reactome:R-HSA-375770 - Reactome:R-HSA-375776 - Reactome:R-HSA-375790 - Reactome:R-HSA-376200 - Reactome:R-HSA-378513 - Reactome:R-HSA-379415 - Reactome:R-HSA-379426 - Reactome:R-HSA-379432 - Reactome:R-HSA-5653850 - Reactome:R-HSA-5655702 - Reactome:R-HSA-5659674 - Reactome:R-HSA-5659734 - Reactome:R-HSA-5659755 - Reactome:R-HSA-5660694 - Reactome:R-HSA-5660890 - Reactome:R-HSA-5660910 - Reactome:R-HSA-888592 - Reactome:R-HSA-8952726 - amino acid permease activity - amino acid/choline transmembrane transporter activity - molecular_function - general amino acid permease activity - hydroxy/aromatic amino acid permease activity - GO:0015171 - amino acid transmembrane transporter activity - - - - - - - - - - - GO_REF:0000090 - - - - - Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. - GOC:ai - GOC:mtg_transport - ISBN:0815340729 - - - - - Reactome:R-HSA-210439 - glutamate uptake by astrocytes - - - - - Reactome:R-HSA-212642 - L-Glutamine transport into neurons - - - - - Reactome:R-HSA-351963 - SLC6A18 transports Gly from extracellular region to cytosol - - - - - Reactome:R-HSA-351987 - SLC6A6-mediated uptake of taurine and beta-alanine - - - - - Reactome:R-HSA-352029 - SLC6A12 (BGT-1)-mediated uptake of GABA and betaine - - - - - Reactome:R-HSA-352052 - SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol - - - - - Reactome:R-HSA-352059 - SLC6A15-mediated amino acid uptake - - - - - Reactome:R-HSA-352103 - SLC43A1 (LAT3)-mediated uptake of large neutral amino acids - - - - - Reactome:R-HSA-352107 - SLC43A2 (LAT4)-mediated uptake of large neutral amino acids - - - - - Reactome:R-HSA-352108 - SLC38A2 (ATA2)-mediated uptake of neutral amino acids - - - - - Reactome:R-HSA-352119 - SLC38A1 (ATA1)-mediated uptake of neutral amino acids - - - - - Reactome:R-HSA-352136 - SLC38A4 (ATA3)-mediated uptake of arginine and lysine - - - - - Reactome:R-HSA-352158 - SLC16A10-mediated uptake of aromatic amino acids - - - - - Reactome:R-HSA-352174 - SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine - - - - - Reactome:R-HSA-352182 - SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine - - - - - Reactome:R-HSA-352191 - SLC7A8-mediated uptake of neutral amino acids - - - - - Reactome:R-HSA-352232 - SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - - - - - Reactome:R-HSA-352347 - SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine - - - - - Reactome:R-HSA-352354 - SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine - - - - - Reactome:R-HSA-352364 - SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - - - - - Reactome:R-HSA-352371 - SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine - - - - - Reactome:R-HSA-352379 - SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane - - - - - Reactome:R-HSA-352385 - SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane - - - - - Reactome:R-HSA-375405 - SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol - - - - - Reactome:R-HSA-375417 - SLC36A1-mediated uptake of glycine, proline, and alanine - - - - - Reactome:R-HSA-375473 - SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol - - - - - Reactome:R-HSA-375487 - SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol - - - - - Reactome:R-HSA-375768 - SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids - - - - - Reactome:R-HSA-375770 - SLC7A3 (CAT-3)-mediated uptake of cationic amino acids - - - - - Reactome:R-HSA-375776 - SLC7A1 (CAT-1)-mediated uptake of cationic amino acids - - - - - Reactome:R-HSA-375790 - SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids - - - - - Reactome:R-HSA-376200 - SLC7A10-mediated uptake of small neutral amino acids - - - - - Reactome:R-HSA-378513 - SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate - - - - - Reactome:R-HSA-379415 - SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - - - - - Reactome:R-HSA-379426 - SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - - - - - Reactome:R-HSA-379432 - SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu - - - - - Reactome:R-HSA-5653850 - Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol - - - - - Reactome:R-HSA-5655702 - Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu - - - - - Reactome:R-HSA-5659674 - Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol - - - - - Reactome:R-HSA-5659734 - Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol - - - - - Reactome:R-HSA-5659755 - Defective SLC6A18 does not transport Gly from extracellular region to cytosol - - - - - Reactome:R-HSA-5660694 - Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol - - - - - Reactome:R-HSA-5660890 - Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu - - - - - Reactome:R-HSA-5660910 - Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane - - - - - Reactome:R-HSA-888592 - Loading of GABA into clathrin sculpted GABA transport vesicle lumen - - - - - Reactome:R-HSA-8952726 - SLC38A9 transports L-Arg from lysosomal lumen to cytosol - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other. - GO:0015392 - molecular_function - GO:0015205 - nucleobase transmembrane transporter activity - - - - - Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon. - https://github.com/geneontology/go-ontology/issues/14372 - inorganic solute uptake transmembrane transporter activity - inorganic uptake permease activity - molecular_function - GO:0015318 - - inorganic molecular entity transmembrane transporter activity - - - - - Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon. - GOC:mtg_transport - ISBN:0815340729 - - - - - - - - - The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. - cellular_component - GO:0015629 - actin cytoskeleton - - - - - The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. - GOC:jl - ISBN:0395825172 - ISBN:0815316194 - - - - - - - - - The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. - cellular_component - GO:0015630 - microtubule cytoskeleton - - - - - The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. - GOC:jl - ISBN:0395825172 - - - - - - - - - The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0015669 - - gas transport - - - - - The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0015671 - oxygen transport - - - - - The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. - biological_process - GO:0015695 - organic cation transport - - - - - The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. - biological_process - GO:0015698 - inorganic anion transport - - - - - The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0015701 - bicarbonate transport - - - - - The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. - biological_process - GO:0015711 - organic anion transport - - - - - The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. - GOC:ai - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0015718 - monocarboxylic acid transport - - - - - The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - bile acid transport - bile salt transport - biological_process - GO:0015721 - bile acid and bile salt transport - - - - - The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:dph - GOC:krc - PMID:12663868 - PMID:14699511 - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0015723 - bilirubin transport - - - - - The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. - vw - 2017-02-19T10:41:27Z - GO:1905950 - biological_process - monosaccharide transport - GO:0015749 - monosaccharide transmembrane transport - - - - - The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. - GOC:TermGenie - GOC:vw - GO_REF:0000069 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. - biological_process - GO:0015774 - polysaccharide transport - - - - - The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0015833 - - peptide transport - - - - - The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - amine/polyamine transport - GO:0015837 - - amine transport - - - - - The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GO:0015873 - biological_process - GO:0015844 - monoamine transport - - - - - The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0015849 - - organic acid transport - - - - - The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. - organic alcohol transport - biological_process - GO:0015850 - organic hydroxy compound transport - - - - - The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - nucleobase transmembrane transport - biological_process - GO:0015851 - nucleobase transport - - - - - The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - ISBN:0198506732 - - - - - nucleobase transmembrane transport - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - DNA-protein complex transport - biological_process - GO:0015869 - protein-DNA complex transport - - - - - The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - DNA-protein complex transport - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. - biological_process - GO:0015870 - acetylcholine transport - - - - - The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. - levarterenol transport - noradrenaline transport - biological_process - GO:0015874 - norepinephrine transport - - - - - The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. - GOC:ai - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - nucleobase, nucleoside, nucleotide and nucleic acid transport - GO:0015931 - - - nucleobase-containing compound transport - - - - - The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - nucleobase, nucleoside, nucleotide and nucleic acid transport - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. - molecular_function - nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity - GO:0015932 - nucleobase-containing compound transmembrane transporter activity - - - - - Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. - GOC:ai - - - - - nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity - GOC:dph - GOC:tb - - - - - - - - - The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. - chemoorganotrophy - biological_process - GO:0015980 - energy derivation by oxidation of organic compounds - - - - - The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. - GOC:mah - - - - - - - - - - A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. - 2014-03-06T11:37:54Z - GO:0016021 - GO:0098589 - GO:0098805 - Wikipedia:Biological_membrane - Wikipedia:Transmembrane_protein - integral component of membrane - integral to membrane - membrane region - region of membrane - whole membrane - cellular_component - transmembrane - GO:0016020 - - - - - - - - membrane - - - - - A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. - GOC:dos - GOC:mah - ISBN:0815316194 - - - - - transmembrane - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. - GO:0006724 - GO:0044240 - Wikipedia:Lipid_catabolism - lipid breakdown - lipid catabolism - lipid degradation - lipolysis - multicellular organism lipid catabolic process - multicellular organismal lipid catabolic process - biological_process - GO:0016042 - lipid catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. - GO:0044235 - GO:0071842 - cell organisation - cellular component organisation at cellular level - cellular component organisation in other organism - cellular component organization at cellular level - cellular component organization in other organism - biological_process - cell organization and biogenesis - GO:0016043 - - - - - cellular component organization - - - - - A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. - GOC:ai - GOC:jl - GOC:mah - - - - - cellular component organisation at cellular level - GOC:mah - - - - - cellular component organisation in other organism - GOC:mah - - - - - cell organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. - GO:0048591 - cellular growth - growth of cell - biological_process - cell expansion - metabolic process resulting in cell growth - metabolism resulting in cell growth - non-developmental cell growth - non-developmental growth of a unicellular organism - GO:0016049 - - - - - cell growth - - - - - The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. - GOC:ai - - - - - non-developmental cell growth - GOC:mah - - - - - non-developmental growth of a unicellular organism - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. - vesicle organisation - biological_process - vesicle organization and biogenesis - GO:0016050 - - - vesicle organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. - GOC:mah - - - - - vesicle organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. - GO:0006093 - anabolic carbohydrate metabolic process - anabolic carbohydrate metabolism - carbohydrate anabolism - carbohydrate biosynthesis - carbohydrate formation - carbohydrate synthesis - biological_process - GO:0016051 - carbohydrate biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. - jl - 2012-10-23T16:34:39Z - GO:0006095 - GO:0044276 - GO:0044724 - carbohydrate breakdown - carbohydrate catabolism - carbohydrate degradation - catabolic carbohydrate metabolic process - catabolic carbohydrate metabolism - multicellular organismal carbohydrate catabolic process - biological_process - single-organism carbohydrate catabolic process - GO:0016052 - carbohydrate catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. - organic acid anabolism - organic acid biosynthesis - organic acid formation - organic acid synthesis - biological_process - GO:0016053 - organic acid biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. - organic acid breakdown - organic acid catabolism - organic acid degradation - biological_process - GO:0016054 - organic acid catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon. - changes in polarization state of photoreceptor cell membrane - biological_process - GO:0016057 - regulation of membrane potential in photoreceptor cell - - - - - Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon. - GOC:dph - GOC:hb - GOC:tb - - - - - changes in polarization state of photoreceptor cell membrane - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. - RNA metabolism - biological_process - GO:0016070 - - - - - - RNA metabolic process - - - - - The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. - https://github.com/geneontology/go-ontology/issues/25421 - GO:0006899 - vesicle transport - vesicular transport - nonselective vesicle transport - biological_process - protein sorting along secretory pathway - vesicle trafficking - GO:0016192 - - - - - - - vesicle-mediated transport - - - - - A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. - GOC:ai - GOC:mah - ISBN:08789310662000 - - - - - vesicular transport - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of striated muscle development. - biological_process - GO:0016202 - regulation of striated muscle tissue development - - - - - Any process that modulates the frequency, rate or extent of striated muscle development. - GOC:go_curators - - - - - - - - - Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. - Reactome:R-HSA-6788855 - Reactome:R-HSA-6788867 - phosphokinase activity - molecular_function - GO:0016301 - - - - - - Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. - kinase activity - - - - - Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. - ISBN:0198506732 - - - - - Reactome:R-HSA-6788855 - FN3KRP phosphorylates PsiAm, RibAm - - - - - Reactome:R-HSA-6788867 - FN3K phosphorylates ketosamines - - - - - - - - - The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. - Wikipedia:Phosphorylation - biological_process - GO:0016310 - - - phosphorylation - - - - - The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female. - biological_process - GO:0016321 - female meiosis chromosome segregation - - - - - The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster. - GO:0048130 - oocyte microtubule cytoskeleton organisation - biological_process - GO:0016325 - oocyte microtubule cytoskeleton organization - - - - - Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster. - GOC:mtg_sensu - PMID:11231123 - - - - - - - - - - The process in which the anatomical structures of embryonic epithelia are generated and organized. - biological_process - GO:0016331 - morphogenesis of embryonic epithelium - - - - - The process in which the anatomical structures of embryonic epithelia are generated and organized. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. - https://github.com/geneontology/go-ontology/issues/24787 - - Wikipedia:Cell_migration - biological_process - GO:0016477 - cell migration - - - - - The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. - GOC:cjm - GOC:dph - GOC:ems - GOC:pf - Wikipedia:Cell_migration - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. - down regulation of angiogenesis - down-regulation of angiogenesis - downregulation of angiogenesis - inhibition of angiogenesis - biological_process - GO:0016525 - negative regulation of angiogenesis - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. - - Wikipedia:Sarcoplasm - cellular_component - GO:0016528 - sarcoplasm - - - - - The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. - ISBN:0198547684 - - - - - - - - - Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. - EC:2.-.-.- - Reactome:R-HSA-1483089 - Reactome:R-HSA-1483186 - Reactome:R-HSA-5668414 - Reactome:R-HSA-8868783 - molecular_function - GO:0016740 - - - - - - - - - - - transferase activity - - - - - Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. - ISBN:0198506732 - - - - - Reactome:R-HSA-1483089 - PE is converted to PS by PTDSS2 - - - - - Reactome:R-HSA-1483186 - PC is converted to PS by PTDSS1 - - - - - Reactome:R-HSA-5668414 - TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK - - - - - Reactome:R-HSA-8868783 - TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248 - - - - - - - - - Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). - EC:2.7.-.- - molecular_function - GO:0016772 - - Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. - transferase activity, transferring phosphorus-containing groups - - - - - Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). - GOC:jl - ISBN:0198506732 - - - - - - - - - Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. - EC:3.-.-.- - Reactome:R-HSA-1236938 - Reactome:R-HSA-2029475 - Reactome:R-HSA-5694583 - Reactome:R-HSA-5695964 - Reactome:R-HSA-6786190 - Reactome:R-HSA-6788295 - Reactome:R-HSA-8938314 - Reactome:R-HSA-8952137 - molecular_function - GO:0016787 - - - - - - - - - - - hydrolase activity - - - - - Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. - ISBN:0198506732 - - - - - Reactome:R-HSA-1236938 - Partial proteolysis of antigen in phagolysosomes - - - - - Reactome:R-HSA-2029475 - Production of AA by iPLA2 upon FCGR activation - - - - - Reactome:R-HSA-5694583 - ABHD4 hydrolyses NAPE - - - - - Reactome:R-HSA-5695964 - ABHD14B hydrolyses PNPB - - - - - Reactome:R-HSA-6786190 - CMBL hydrolyses OM to OLMS - - - - - Reactome:R-HSA-6788295 - HDHD1:Mg2+ dephosphorylates PURIDP - - - - - Reactome:R-HSA-8938314 - ENPPs hydrolyse CoA-SH to PPANT, PAP - - - - - Reactome:R-HSA-8952137 - Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate - - - - - - - - - Catalysis of the hydrolysis of any ester bond. - EC:3.1.-.- - Reactome:R-HSA-162729 - Reactome:R-HSA-9023617 - Reactome:R-HSA-9023619 - Reactome:R-HSA-9749609 - esterase activity - molecular_function - GO:0016788 - - hydrolase activity, acting on ester bonds - - - - - Catalysis of the hydrolysis of any ester bond. - GOC:jl - - - - - Reactome:R-HSA-162729 - uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid - - - - - Reactome:R-HSA-9023617 - Butyrylcholinesterase hydrolyzes acyl Ghrelin - - - - - Reactome:R-HSA-9023619 - Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin - - - - - Reactome:R-HSA-9749609 - BCHE hydrolyzes ASA- - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects. - biological_process - insecticide resistance - insecticide susceptibility/resistance - GO:0017085 - response to insecticide - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects. - GOC:curators - - - - - - - - - - - - - - - - - - - - - - - - - - - A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. - nucleolus biogenesis - nucleolus assembly - biological_process - GO:0017126 - nucleologenesis - - - - - A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. - GOC:jl - ISBN:0198506732 - - - - - nucleolus assembly - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. - stem cell renewal - biological_process - GO:0017145 - stem cell division - - - - - The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. - GOC:jid - ISBN:0582227089 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. - GO:0016478 - down regulation of protein biosynthetic process - down-regulation of protein biosynthetic process - downregulation of protein biosynthetic process - negative regulation of protein anabolism - negative regulation of protein biosynthesis - negative regulation of protein biosynthetic process - negative regulation of protein formation - negative regulation of protein synthesis - inhibition of protein biosynthetic process - biological_process - protein biosynthesis inhibitor activity - protein biosynthetic process inhibitor activity - GO:0017148 - negative regulation of translation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. - GOC:isa_complete - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of exocytosis. - biological_process - GO:0017157 - regulation of exocytosis - - - - - Any process that modulates the frequency, rate or extent of exocytosis. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). - heterocycle anabolism - heterocycle biosynthesis - heterocycle formation - heterocycle synthesis - biological_process - GO:0018130 - heterocycle biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). - ISBN:0198547684 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. - UM-BBD_pathwayID:phe - carbolic acid metabolic process - carbolic acid metabolism - hydroxybenzene metabolic process - hydroxybenzene metabolism - phenol-containing compound metabolism - biological_process - GO:0018958 - Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. - phenol-containing compound metabolic process - - - - - The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The specific behavior of an organism that is associated with reproduction. - https://github.com/geneontology/go-ontology/issues/23491 - jl - 2012-09-19T16:01:37Z - GO:0033057 - GO:0044704 - GO:0044705 - reproductive behavior in a multicellular organism - reproductive behaviour - multi-organism reproductive behavior - multicellular organism reproductive behavior - biological_process - single-organism reproductive behavior - GO:0019098 - reproductive behavior - - - - - The specific behavior of an organism that is associated with reproduction. - GOC:jl - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. - regulation of lipid metabolism - biological_process - GO:0019216 - regulation of lipid metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. - regulation of steroid metabolism - biological_process - GO:0019218 - regulation of steroid metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. - regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism - biological_process - regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - GO:0019219 - regulation of nucleobase-containing compound metabolic process - - - - - Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. - GOC:go_curators - - - - - regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates. - regulation of phosphate metabolism - biological_process - GO:0019220 - regulation of phosphate metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - GO:0044246 - regulation of metabolism - regulation of multicellular organismal metabolic process - regulation of organismal metabolic process - biological_process - GO:0019222 - - regulation of metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. - GOC:go_curators - - - - - regulation of organismal metabolic process - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. - conduction of nerve impulse - signal transmission along a neuron - biological_process - GO:0019226 - transmission of nerve impulse - - - - - The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. - GOC:curators - ISBN:0815316194 - - - - - conduction of nerve impulse - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An action potential that occurs in a neuron. - biological_process - generation of action potential - GO:0019228 - neuronal action potential - - - - - An action potential that occurs in a neuron. - GOC:dph - GOC:isa_complete - GOC:tb - - - - - generation of action potential - GOC:dph - GOC:tb - - - - - - - - - The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. - Wikipedia:Nociception - perception of physiological pain - biological_process - nociception - GO:0019233 - sensory perception of pain - - - - - The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. - GOC:curators - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. - hexose metabolism - biological_process - GO:0019318 - hexose metabolic process - - - - - The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. - hexose anabolism - hexose biosynthesis - hexose formation - hexose synthesis - biological_process - GO:0019319 - hexose biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. - hexose breakdown - hexose catabolism - hexose degradation - biological_process - GO:0019320 - hexose catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. - MetaCyc:PHENOLDEG-PWY - phenol-containing compound breakdown - phenol-containing compound catabolism - phenol-containing compound degradation - biological_process - GO:0019336 - phenol-containing compound catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid. - acetate anabolism - acetate biosynthesis - acetate formation - acetate synthesis - biological_process - GO:0019413 - acetate biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring. - aromatic compound anabolism - aromatic compound biosynthesis - aromatic compound formation - aromatic compound synthesis - aromatic hydrocarbon biosynthesis - aromatic hydrocarbon biosynthetic process - biological_process - GO:0019438 - aromatic compound biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. - aromatic compound breakdown - aromatic compound catabolism - aromatic compound degradation - aromatic hydrocarbon catabolic process - aromatic hydrocarbon catabolism - biological_process - GO:0019439 - aromatic compound catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving a protein. Includes protein modification. - https://github.com/geneontology/go-ontology/issues/23112 - GO:0006411 - GO:0044267 - GO:0044268 - Wikipedia:Protein_metabolism - cellular protein metabolic process - cellular protein metabolism - protein metabolic process and modification - protein metabolism - protein metabolism and modification - multicellular organismal protein metabolic process - biological_process - GO:0019538 - - - - - - protein metabolic process - - - - - The chemical reactions and pathways involving a protein. Includes protein modification. - GOC:ma - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. - biological_process - catechol breakdown - catechol catabolic process - catechol catabolism - catechol degradation - GO:0019614 - catechol-containing compound catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process involved in the maintenance of an internal steady state at the level of the cell. - biological_process - GO:0019725 - - - cellular homeostasis - - - - - Any process involved in the maintenance of an internal steady state at the level of the cell. - GOC:isa_complete - GOC:jl - ISBN:0395825172 - - - - - - - - - The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. - Wikipedia:Secondary_metabolism - secondary metabolism - secondary metabolite metabolic process - secondary metabolite metabolism - biological_process - GO:0019748 - - - - - secondary metabolic process - - - - - The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). - carboxylic acid metabolism - biological_process - GO:0019752 - carboxylic acid metabolic process - - - - - The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - one carbon compound transport - biological_process - GO:0019755 - one-carbon compound transport - - - - - The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. - cellular_component - GO:0019867 - - outer membrane - - - - - The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. - GOC:go_curators - - - - - - - - - A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid). - https://github.com/geneontology/go-ontology/issues/22929 - Wikipedia:Sexual_reproduction - biological_process - GO:0019953 - Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. - sexual reproduction - - - - - A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid). - Wikipedia:Sexual_reproduction - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells. - biological_process - GO:0021501 - prechordal plate formation - - - - - The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. - biological_process - GO:0021510 - spinal cord development - - - - - The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. - biological_process - GO:0021514 - ventral spinal cord interneuron differentiation - - - - - The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - PMID:11262869 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. - biological_process - GO:0021515 - cell differentiation in spinal cord - - - - - The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - PMID:11262869 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. - biological_process - GO:0021517 - ventral spinal cord development - - - - - The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. - biological_process - GO:0021522 - spinal cord motor neuron differentiation - - - - - The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - PMID:11262869 - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. - biological_process - GO:0021523 - somatic motor neuron differentiation - - - - - The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - PMID:11262869 - - - - - - - - - - - - - - - The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. - biological_process - GO:0021532 - neural tube patterning - - - - - The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. - biological_process - GO:0021533 - cell differentiation in hindbrain - - - - - The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain. - biological_process - GO:0021534 - cell proliferation in hindbrain - - - - - The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The orderly movement of a cell that will reside in the hindbrain. - biological_process - GO:0021535 - cell migration in hindbrain - - - - - The orderly movement of a cell that will reside in the hindbrain. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. - biological_process - GO:0021545 - cranial nerve development - - - - - The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. - biological_process - GO:0021546 - rhombomere development - - - - - The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. - MHB biosynthesis - MHB formation - midbrain-hindbrain boundary biosynthesis - midbrain-hindbrain boundary formation - biological_process - isthmus biosynthesis - isthmus formation - GO:0021547 - midbrain-hindbrain boundary initiation - - - - - The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. - GOC:cls - GOC:dgh - GOC:dph - GOC:isa_complete - GOC:jid - GO_REF:0000021 - PMID:15541513 - - - - - MHB biosynthesis - GOC:cls - - - - - MHB formation - GOC:cls - - - - - midbrain-hindbrain boundary biosynthesis - GOC:cls - - - - - midbrain-hindbrain boundary formation - GOC:cls - - - - - isthmus biosynthesis - GOC:cls - - - - - isthmus formation - GOC:cls - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. - biological_process - GO:0021548 - pons development - - - - - The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. - biological_process - medulla development - myelencephalon development - GO:0021550 - medulla oblongata development - - - - - The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - medulla development - GOC:cls - - - - - myelencephalon development - GOC:cls - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. - biological_process - GO:0021551 - central nervous system morphogenesis - - - - - The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0582227089 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. - MHB morphogenesis - isthmus morphogenesis - biological_process - GO:0021555 - midbrain-hindbrain boundary morphogenesis - - - - - The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - PMID:15541513 - - - - - MHB morphogenesis - GOC:cls - - - - - isthmus morphogenesis - GOC:cls - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. - biological_process - GO:0021556 - central nervous system formation - - - - - The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0582227089 - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. - cranial nerve 5 development - cranial nerve V development - biological_process - CN V development - GO:0021559 - trigeminal nerve development - - - - - The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - cranial nerve 5 development - GOC:cls - - - - - cranial nerve V development - GOC:cls - - - - - CN V development - GOC:cls - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. - biological_process - rhombencephalon morphogenesis - GO:0021575 - hindbrain morphogenesis - - - - - The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. - biological_process - GO:0021576 - hindbrain formation - - - - - The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. - biological_process - GO:0021578 - hindbrain maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. - biological_process - medulla morphogenesis - myelencephalon morphogenesis - GO:0021579 - medulla oblongata morphogenesis - - - - - The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. - biological_process - medulla biosynthesis - medulla formation - myelencephalon biosynthesis - myelencephalon formation - GO:0021580 - medulla oblongata formation - - - - - The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. - biological_process - medulla maturation - myelencephalon maturation - GO:0021582 - medulla oblongata maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. - biological_process - GO:0021583 - pons morphogenesis - - - - - The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. - biological_process - GO:0021584 - pons formation - - - - - The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. - biological_process - GO:0021586 - pons maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. - biological_process - GO:0021593 - rhombomere morphogenesis - - - - - The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. - biological_process - GO:0021594 - rhombomere formation - - - - - The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. - biological_process - GO:0021602 - cranial nerve morphogenesis - - - - - The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. - biological_process - GO:0021603 - cranial nerve formation - - - - - The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. - biological_process - GO:0021605 - cranial nerve maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. - biological_process - GO:0021626 - central nervous system maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0582227089 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. - biological_process - CN V maturation - GO:0021635 - trigeminal nerve maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. - biological_process - CN V morphogenesis - GO:0021636 - trigeminal nerve morphogenesis - - - - - The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. - biological_process - CN V biosynthesis - CN V formation - GO:0021638 - trigeminal nerve formation - - - - - The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. - biological_process - GO:0021654 - rhombomere boundary formation - - - - - The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. - biological_process - GO:0021675 - nerve development - - - - - The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state. - biological_process - GO:0021682 - nerve maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. - biological_process - GO:0021700 - - developmental maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. - locus caeruleus development - locus coeruleus development - biological_process - GO:0021703 - locus ceruleus development - - - - - The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. - biological_process - GO:0021704 - locus ceruleus morphogenesis - - - - - The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. - biological_process - GO:0021705 - locus ceruleus formation - - - - - The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. - biological_process - GO:0021706 - locus ceruleus maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. - biological_process - superior olive development - GO:0021718 - superior olivary nucleus development - - - - - The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. - biological_process - superior olive morphogenesis - GO:0021719 - superior olivary nucleus morphogenesis - - - - - The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. - biological_process - GO:0021720 - superior olivary nucleus formation - - - - - The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. - biological_process - superior olive maturation - GO:0021722 - superior olivary nucleus maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0838580343 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. - biological_process - MHB maturation - isthmus maturation - GO:0021732 - midbrain-hindbrain boundary maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - PMID:15541513 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure. - biological_process - GO:0021751 - salivary nucleus development - - - - - The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure. - GOC:cls - GOC:curators - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure. - biological_process - GO:0021753 - superior salivary nucleus development - - - - - The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure. - GOC:cls - GOC:curators - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. - biological_process - GO:0021782 - glial cell development - - - - - The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - The process in which the neural tube is divided into specific regions along the rostrocaudal axis. - biological_process - anterior-posterior neural tube patterning - GO:0021903 - rostrocaudal neural tube patterning - - - - - The process in which the neural tube is divided into specific regions along the rostrocaudal axis. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - PMID:11262869 - - - - - anterior-posterior neural tube patterning - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the formation of the hindbrain-spinal cord boundary. - biological_process - GO:0021906 - hindbrain-spinal cord boundary formation - - - - - The process whose specific outcome is the formation of the hindbrain-spinal cord boundary. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - PMID:11262869 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. - biological_process - GO:0021915 - neural tube development - - - - - The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. - biological_process - GO:0021953 - central nervous system neuron differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. - biological_process - GO:0021954 - central nervous system neuron development - - - - - The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. - biological_process - GO:0021990 - neural plate formation - - - - - The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - ISBN:0878932437 - ISBN:0878932585 - PMID:15806586 - - - - - - - - - - The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate. - biological_process - neural plate anterior/posterior pattern formation - GO:0021999 - neural plate anterior/posterior regionalization - - - - - The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - neural plate anterior/posterior pattern formation - GOC:dph - - - - - - - - - - - - - - - Generation of cells within the nervous system. - Wikipedia:Neurogenesis - nervous system cell generation - biological_process - neural cell differentiation - GO:0022008 - neurogenesis - - - - - Generation of cells within the nervous system. - GOC:cls - GOC:curators - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - nervous system cell generation - - - - - - neural cell differentiation - GOC:BHF - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier. - https://github.com/geneontology/go-ontology/issues/21480 - biological_process - GO:0022009 - central nervous system vasculogenesis - - - - - The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere. - biological_process - GO:0022035 - rhombomere cell migration - - - - - The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere. - GOC:cls - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - PMID:15629700 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. - biological_process - GO:0022037 - metencephalon development - - - - - The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. - GOC:cls - GOC:curators - GOC:dgh - GOC:dph - GOC:jid - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. - biological_process - GO:0022402 - - cell cycle process - - - - - The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. - GOC:isa_complete - GOC:mtg_cell_cycle - - - - - - - - - The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. - biological_process - GO:0022406 - - membrane docking - - - - - The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. - GOC:isa_complete - PMID:27875684 - - - - - - - - - - - - - - - - - - - - - - - - - - - A cellular process that results in the breakdown of a cellular component. - GO:0071845 - cell structure disassembly - cellular component disassembly at cellular level - biological_process - GO:0022411 - - cellular component disassembly - - - - - A cellular process that results in the breakdown of a cellular component. - GOC:isa_complete - - - - - - - - - - - - - - - - - - - - - - - - - - - A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. - reproductive cellular process in multicellular organism - biological_process - GO:0022412 - cellular process involved in reproduction in multicellular organism - - - - - A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. - GOC:isa_complete - - - - - - - - - - - - - - - - - - - - - - - - - - A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. - jl - 2012-09-19T15:56:06Z - GO:0044702 - biological_process - single organism reproductive process - GO:0022414 - - reproductive process - - - - - A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. - GOC:dph - GOC:isa_complete - - - - - - - - - - - - - - - - - - - - - - - - - - A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. - biological_process - GO:0022600 - - digestive system process - - - - - A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. - GOC:isa_complete - GOC:jid - GOC:mtg_cardio - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. - regulation of morphogenesis - biological_process - GO:0022603 - regulation of anatomical structure morphogenesis - - - - - Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. - biological_process - negative regulation of cell shape and cell size - positive regulation of cell shape and cell size - regulation of cell shape and cell size - GO:0022604 - regulation of cell morphogenesis - - - - - Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. - GOC:isa_complete - - - - - negative regulation of cell shape and cell size - GOC:dph - GOC:tb - - - - - positive regulation of cell shape and cell size - GOC:dph - GOC:tb - - - - - regulation of cell shape and cell size - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of a cellular component. - GO:0071844 - cell structure assembly - cellular component assembly at cellular level - biological_process - GO:0022607 - - - cellular component assembly - - - - - The aggregation, arrangement and bonding together of a cellular component. - GOC:isa_complete - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of a gland are generated and organized. - biological_process - GO:0022612 - gland morphogenesis - - - - - The process in which the anatomical structures of a gland are generated and organized. - GOC:isa_complete - - - - - - - - - A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. - RNA-protein complex biogenesis - ribonucleoprotein complex biogenesis and assembly - biological_process - GO:0022613 - ribonucleoprotein complex biogenesis - - - - - A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. - GOC:isa_complete - GOC:mah - - - - - RNA-protein complex biogenesis - GOC:mah - - - - - ribonucleoprotein complex biogenesis and assembly - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that results in the breakdown of the extracellular matrix. - biological_process - GO:0022617 - extracellular matrix disassembly - - - - - A process that results in the breakdown of the extracellular matrix. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. - RNA-protein complex assembly - RNP complex assembly - ribonucleoprotein complex assembly - biological_process - GO:0022618 - - protein-RNA complex assembly - - - - - The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. - GOC:jl - - - - - - - - - Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. - active carrier activity - carrier activity - permease activity - pump activity - molecular_function - GO:0022804 - active transmembrane transporter activity - - - - - Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. - GOC:mtg_transport - ISBN:0815340729 - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction. - https://github.com/geneontology/go-ontology/issues/24479 - active ion transmembrane transporter activity - molecular_function - GO:0022853 - active monoatomic ion transmembrane transporter activity - - - - - Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction. - GOC:mtg_transport - ISBN:0815340729 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. - GO:0005386 - GO:0015563 - GO:0015646 - GO:0022891 - GO:0022892 - Reactome:R-HSA-1236947 - Reactome:R-HSA-429036 - Reactome:R-HSA-434650 - Reactome:R-HSA-5638209 - Reactome:R-HSA-5671707 - Reactome:R-HSA-6784434 - Reactome:R-HSA-6784436 - molecular_function - substrate-specific transmembrane transporter activity - substrate-specific transporter activity - uptake permease activity - uptake transmembrane transporter activity - GO:0022857 - - - - transmembrane transporter activity - - - - - Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. - GOC:jid - GOC:mtg_transport - ISBN:0815340729 - - - - - Reactome:R-HSA-1236947 - Egress of internalized antigen to the cytosol via sec61 - - - - - Reactome:R-HSA-429036 - SLC2A9 transports Fru, Glc, urate - - - - - Reactome:R-HSA-434650 - MATEs mediate extrusion of xenobiotics - - - - - Reactome:R-HSA-5638209 - Defective SLC2A9 does not transport Fru, Glc, urate - - - - - Reactome:R-HSA-5671707 - Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA - - - - - Reactome:R-HSA-6784434 - An unknown carrier transports cytosolic glyoxylate to the peroxisome - - - - - Reactome:R-HSA-6784436 - An unknown carrier transports mitochondrial glyoxylate to the cytosol - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of a macromolecule from one side of a membrane to the other. - molecular_function - GO:0022884 - macromolecule transmembrane transporter activity - - - - - Enables the transfer of a macromolecule from one side of a membrane to the other. - GOC:mtg_transport - ISBN:0815340729 - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. - GO:0015077 - GO:0015082 - GO:0072509 - GO:0072510 - di-, tri-valent inorganic cation transmembrane transporter activity - divalent inorganic cation transmembrane transporter activity - monovalent inorganic cation transmembrane transporter activity - trivalent inorganic cation transmembrane transporter activity - molecular_function - GO:0022890 - inorganic cation transmembrane transporter activity - - - - - Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. - GOC:ai - GOC:mtg_transport - ISBN:0815340729 - - - - - di-, tri-valent inorganic cation transmembrane transporter activity - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of transmembrane transporter activity. - biological_process - GO:0022898 - - regulation of transmembrane transporter activity - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of transmembrane transporter activity. - GOC:dph - GOC:mtg_cardio - GOC:mtg_transport - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. - 2010-02-16T09:30:50Z - biological_process - regulation of gene expression as a consequence of signal transmission - GO:0023019 - signal transduction involved in regulation of gene expression - - - - - Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. - GOC:mtg_signal - - - - - regulation of gene expression as a consequence of signal transmission - GOC:bf - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a signaling process. - 2010-02-16T09:30:50Z - biological_process - regulation of signaling process - regulation of signalling process - GO:0023051 - regulation of signaling - - - - - Any process that modulates the frequency, rate or extent of a signaling process. - GOC:mtg_signal - - - - - regulation of signaling process - GOC:bf - - - - - regulation of signalling process - GOC:mah - - - - - - - - - The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. - jl - 2010-02-16T09:30:50Z - GO:0023046 - GO:0044700 - biological signaling - signaling process - signalling - biological_process - signalling process - single organism signaling - GO:0023052 - - - - - - - - Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. - signaling - - - - - The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. - GOC:mtg_signal - GOC:mtg_signaling_feb11 - GOC:signaling - - - - - signalling process - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. - 2010-02-16T09:30:50Z - positive regulation of signalling process - biological_process - positive regulation of signaling process - GO:0023056 - positive regulation of signaling - - - - - Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. - GOC:mtg_signal - - - - - positive regulation of signalling process - GOC:mah - - - - - positive regulation of signaling process - GOC:bf - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. - 2010-02-16T09:30:50Z - biological_process - negative regulation of signaling process - negative regulation of signalling process - GO:0023057 - negative regulation of signaling - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. - GOC:mtg_signal - - - - - negative regulation of signaling process - GOC:bf - - - - - negative regulation of signalling process - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. - 2010-02-16T09:30:50Z - signal secretion - biological_process - GO:0023061 - signal release - - - - - The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. - GOC:mtg_signal - - - - - signal secretion - GOC:bf - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - https://github.com/geneontology/go-ontology/issues/23033 - mah - 2009-07-31T01:07:46Z - GO:0070838 - GO:0070839 - divalent metal ion export - divalent metal ion transport - heavy metal ion transport - metal ion export - biological_process - GO:0030001 - metal ion transport - - - - - The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - The specification and formation of anisotropic intracellular organization or cell growth patterns. - GO:0000283 - GO:0030468 - cell polarization - bud site selection/establishment of cell polarity - biological_process - GO:0030010 - establishment of cell polarity - - - - - The specification and formation of anisotropic intracellular organization or cell growth patterns. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. - Wikipedia:Myofibril - cellular_component - GO:0030016 - myofibril - - - - - The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. - ISBN:0815316194 - - - - - - - - - - - - - - - - - - - - - - The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. - Wikipedia:Sarcomere - cellular_component - GO:0030017 - sarcomere - - - - - The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. - ISBN:0815316194 - - - - - - - - - - - - - - - - - - - - - - - - - - Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. - biological_process - microfilament-based process - GO:0030029 - actin filament-based process - - - - - Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. - cell projection organisation - biological_process - cell projection organization and biogenesis - cell surface structure organization and biogenesis - GO:0030030 - - cell projection organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. - GOC:jl - GOC:mah - http://www.cogsci.princeton.edu/~wn/ - - - - - cell projection organization and biogenesis - GOC:mah - - - - - cell surface structure organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. - formation of a cell surface projection - biological_process - cell projection biogenesis - GO:0030031 - cell projection assembly - - - - - Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. - GOC:jl - GOC:mah - http://www.cogsci.princeton.edu/~wn/ - - - - - cell projection biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. - biological_process - microvillus biogenesis - GO:0030033 - microvillus assembly - - - - - Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. - GOC:mah - ISBN:0815316194 - - - - - microvillus biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. - https://github.com/geneontology/go-ontology/issues/23114 - actin cytoskeleton organisation - biological_process - actin cytoskeleton organization and biogenesis - actin modulating activity - GO:0030036 - - actin cytoskeleton organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. - GOC:dph - GOC:jl - GOC:mah - - - - - actin cytoskeleton organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. - https://github.com/geneontology/go-ontology/issues/19809 - biological_process - GO:0030048 - actin filament-based movement - - - - - Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. - GOC:BHF - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Movement of a vesicle along an actin filament, mediated by motor proteins. - biological_process - GO:0030050 - vesicle transport along actin filament - - - - - Movement of a vesicle along an actin filament, mediated by motor proteins. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. - - Wikipedia:Cell_junction - cellular_component - GO:0030054 - - - - cell junction - - - - - A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. - GOC:aruk - GOC:bc - GOC:mah - ISBN:0198506732 - PMID:26820516 - PMID:28096264 - http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html - - - - - - - - - - - - - - - - - - - - - - - - - - - The regulated release of a peptide hormone from a cell. - biological_process - GO:0030072 - peptide hormone secretion - - - - - The regulated release of a peptide hormone from a cell. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. - https://github.com/geneontology/go-ontology/issues/11255#issuecomment-426191045 - biological_process - GO:0030073 - insulin secretion - - - - - The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. - GOC:mah - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. - https://github.com/geneontology/go-ontology/issues/22178 - Wikipedia:Haematopoiesis - blood cell biosynthesis - blood cell formation - haemopoiesis - hematopoiesis - biological_process - GO:0030097 - hemopoiesis - - - - - The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. - GOC:dgh - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. - biological_process - GO:0030099 - myeloid cell differentiation - - - - - The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. - GOC:add - ISBN:0781735149 - - - - - - - - - - - - - - - Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. - NIF_Subcellular:sao885490876 - constitutive secretory pathway transport vesicle - Golgi to vacuole transport vesicle - Golgi-vacuole transport vesicle - cellular_component - secretory vesicle - GO:0030133 - Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'. - transport vesicle - - - - - Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. - GOC:mah - PMID:22160157 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. - - secretory vesicle - cellular_component - GO:0030141 - Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'. - secretory granule - - - - - A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. - GOC:mah - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. - https://github.com/geneontology/go-ontology/issues/24390 - Wikipedia:Cellular_differentiation - biological_process - GO:0030154 - - - - - - - cell differentiation - - - - - The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. - https://github.com/geneontology/go-ontology/issues/23112 - GO:0044254 - GO:0044257 - Wikipedia:Protein_catabolism - cellular protein breakdown - cellular protein catabolic process - cellular protein catabolism - cellular protein degradation - protein breakdown - protein catabolism - protein degradation - multicellular organismal protein catabolic process - biological_process - pheromone catabolic process - pheromone catabolism - GO:0030163 - - - - - - This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children. - protein catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a neuron. - biological_process - GO:0030182 - neuron differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a neuron. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. - extracellular matrix organisation - biological_process - extracellular matrix organization and biogenesis - GO:0030198 - - - - extracellular matrix organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. - GOC:mah - - - - - extracellular matrix organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. - - collagen fibril organisation - fibrillar collagen organization - biological_process - GO:0030199 - collagen fibril organization - - - - - Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. - GOC:mah - ISBN:0815316194 - - - - - fibrillar collagen organization - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. - glycosaminoglycan metabolism - biological_process - GO:0030203 - glycosaminoglycan metabolic process - - - - - The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. - ISBN:0192800981 - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. - hyaluronan metabolism - biological_process - GO:0030212 - hyaluronan metabolic process - - - - - The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. - GOC:mah - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. - hyaluronan anabolism - hyaluronan biosynthesis - hyaluronan formation - hyaluronan synthesis - biological_process - GO:0030213 - hyaluronan biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. - GOC:mah - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. - hyaluronan breakdown - hyaluronan catabolism - hyaluronan degradation - biological_process - GO:0030214 - hyaluronan catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. - GOC:mah - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. - Wikipedia:Erythropoiesis - RBC differentiation - erythrocyte cell differentiation - erythropoiesis - red blood cell differentiation - biological_process - GO:0030218 - erythrocyte differentiation - - - - - The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. - GOC:mah - - - - - RBC differentiation - CL:0000232 - - - - - erythropoiesis - GOC:add - GOC:dph - - - - - red blood cell differentiation - CL:0000232 - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. - megakaryocyte cell differentiation - biological_process - GO:0030219 - megakaryocyte differentiation - - - - - The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Formation of myofibrils, the repeating units of striated muscle. - biological_process - GO:0030239 - myofibril assembly - - - - - Formation of myofibrils, the repeating units of striated muscle. - GOC:mah - - - - - - - - - The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. - GO:0000068 - DNA condensation - eukaryotic chromosome condensation - nuclear chromosome condensation - biological_process - GO:0030261 - chromosome condensation - - - - - The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. - GOC:mah - ISBN:0815316194 - - - - - DNA condensation - Wikipedia:DNA_condensation - - - - - eukaryotic chromosome condensation - GOC:bf - - - - - nuclear chromosome condensation - GOC:bf - - - - - - - - - Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. - apoptotic nuclear change - biological_process - GO:0030262 - apoptotic nuclear changes - - - - - Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. - GOC:mah - GOC:mtg_apoptosis - - - - - - - - - - - - - - - The compaction of chromatin during apoptosis. - Wikipedia:Pyknosis - pyknosis - biological_process - GO:0030263 - apoptotic chromosome condensation - - - - - The compaction of chromatin during apoptosis. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA. - apoptotic nuclear fragmentation - nucleus fragmentation - biological_process - nuclear fragmentation during apoptosis - GO:0030264 - nuclear fragmentation involved in apoptotic nuclear change - - - - - The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA. - GOC:dph - GOC:mah - GOC:mtg_apoptosis - GOC:tb - ISBN:0721639976 - - - - - nuclear fragmentation during apoptosis - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. - regulation of bone biosynthesis - regulation of bone formation - biological_process - GO:0030278 - regulation of ossification - - - - - Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. - down regulation of ossification - down-regulation of ossification - downregulation of ossification - negative regulation of bone biosynthesis - negative regulation of bone formation - inhibition of ossification - biological_process - GO:0030279 - negative regulation of ossification - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate, extent or direction of cell growth. - up regulation of cell growth - up-regulation of cell growth - upregulation of cell growth - activation of cell growth - stimulation of cell growth - biological_process - GO:0030307 - positive regulation of cell growth - - - - - Any process that activates or increases the frequency, rate, extent or direction of cell growth. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. - down regulation of cell growth - down-regulation of cell growth - downregulation of cell growth - inhibition of cell growth - biological_process - GO:0030308 - negative regulation of cell growth - - - - - Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space. - cellular_component - GO:0030312 - - - - - - The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'. - external encapsulating structure - - - - - A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract. - biological_process - GO:0030323 - respiratory tube development - - - - - The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. - biological_process - GO:0030324 - lung development - - - - - The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. - GOC:jid - UBERON:0002048 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cell migration. - biological_process - GO:0030334 - regulation of cell migration - - - - - Any process that modulates the frequency, rate or extent of cell migration. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cell migration. - up regulation of cell migration - up-regulation of cell migration - upregulation of cell migration - activation of cell migration - stimulation of cell migration - biological_process - GO:0030335 - positive regulation of cell migration - - - - - Any process that activates or increases the frequency, rate or extent of cell migration. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. - down regulation of cell migration - down-regulation of cell migration - downregulation of cell migration - inhibition of cell migration - biological_process - GO:0030336 - negative regulation of cell migration - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. - membrane breakdown - membrane catabolism - membrane degradation - biological_process - GO:0030397 - membrane disassembly - - - - - The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. - GOC:mah - - - - - - - - - - - - - - - - The expulsion of feces from the rectum. - Wikipedia:Defecation - biological_process - GO:0030421 - defecation - - - - - The expulsion of feces from the rectum. - GOC:mah - - - - - - - - - A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. - Wikipedia:Peristalsis - biological_process - GO:0030432 - peristalsis - - - - - A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins. - GO:0000065 - nuclear movement, microtubule-mediated - nucleus migration - microtubule cytoskeleton-dependent nuclear positioning - microtubule cytoskeleton-dependent nucleus positioning - microtubule-dependent nuclear positioning - microtubule-dependent nucleus positioning - microtubule-mediated nuclear migration - nuclear migration, microtubule-mediated - transport of nucleus by microtubules - transport of nucleus, microtubule-mediated - biological_process - GO:0030473 - nuclear migration along microtubule - - - - - The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins. - GOC:mah - GOC:sgd_curators - - - - - - - - - - - - - - - - - - - - - - - - - - The contractile fiber of smooth muscle cells. - cellular_component - GO:0030485 - smooth muscle contractile fiber - - - - - The contractile fiber of smooth muscle cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile. - GO:0019613 - bile acid breakdown - bile acid catabolism - bile acid degradation - bile acid 7alpha-dehydroxylation pathway - cholate catabolic process - biological_process - GO:0030573 - bile acid catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. - collagen breakdown - collagen catabolism - collagen degradation - biological_process - GO:0030574 - collagen catabolic process - - - - - The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. - GOC:mah - ISBN:0815316194 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The lipid bilayer surrounding a transport vesicle. - secretory vesicle membrane - constitutive secretory pathway transport vesicle membrane - cellular_component - GO:0030658 - transport vesicle membrane - - - - - The lipid bilayer surrounding a transport vesicle. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The lipid bilayer surrounding a cytoplasmic vesicle. - cellular_component - GO:0030659 - cytoplasmic vesicle membrane - - - - - The lipid bilayer surrounding a cytoplasmic vesicle. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. - cellular_component - Golgi vesicle membrane - GO:0030660 - Golgi-associated vesicle membrane - - - - - The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The lipid bilayer surrounding a secretory granule. - secretory vesicle membrane - cellular_component - GO:0030667 - secretory granule membrane - - - - - The lipid bilayer surrounding a secretory granule. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. - biological_process - GO:0030705 - - - cytoskeleton-dependent intracellular transport - - - - - The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber. - establishment and maintenance of oocyte localization in egg chamber - establishment and maintenance of oocyte position during oogenesis - oocyte localisation involved in germarium-derived egg chamber formation - oogenesis, establishment and maintenance of oocyte localization - oogenesis, oocyte localization - oocyte positioning during oogenesis - biological_process - oocyte localization during germarium-derived egg chamber formation - oocyte localization during oogenesis - GO:0030720 - oocyte localization involved in germarium-derived egg chamber formation - - - - - Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber. - GOC:mtg_sensu - PMID:10449356 - - - - - oocyte localisation involved in germarium-derived egg chamber formation - GOC:mah - - - - - oocyte localization during germarium-derived egg chamber formation - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. - biological_process - GO:0030855 - epithelial cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. - GOC:ecd - PMID:11839751 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of epithelial cell differentiation. - biological_process - GO:0030856 - regulation of epithelial cell differentiation - - - - - Any process that modulates the frequency, rate or extent of epithelial cell differentiation. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. - down regulation of epithelial cell differentiation - down-regulation of epithelial cell differentiation - downregulation of epithelial cell differentiation - inhibition of epithelial cell differentiation - biological_process - GO:0030857 - negative regulation of epithelial cell differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. - up regulation of epithelial cell differentiation - up-regulation of epithelial cell differentiation - upregulation of epithelial cell differentiation - activation of epithelial cell differentiation - stimulation of epithelial cell differentiation - biological_process - GO:0030858 - positive regulation of epithelial cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). - mesencephalon development - biological_process - GO:0030901 - midbrain development - - - - - The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). - http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=midbrain - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). - rhombencephalon development - biological_process - GO:0030902 - hindbrain development - - - - - The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). - http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=hindbrain - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. - biological_process - GO:0030903 - notochord development - - - - - The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. - GOC:dgh - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. - MHB development - isthmic organizer development - isthmomesencephalic boundary development - isthmus development - midbrain-hindbrain orgainizer development - biological_process - GO:0030917 - midbrain-hindbrain boundary development - - - - - The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. - GOC:dgh - - - - - - - - - - - - - - - - - - - - - - - - - - - Any collagen trimer that passes through a lipid bilayer membrane. - MACIT - cellular_component - GO:0030936 - transmembrane collagen trimer - - - - - Any collagen trimer that passes through a lipid bilayer membrane. - ISBN:0721639976 - - - - - MACIT - ISBN:0198599587 - - - - - - - - - - Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures. - biological_process - GO:0030951 - establishment or maintenance of microtubule cytoskeleton polarity - - - - - Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures. - GOC:mah - - - - - - - - - - Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures. - biological_process - cytoskeleton polarization - GO:0030952 - establishment or maintenance of cytoskeleton polarity - - - - - Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures. - GOC:mah - - - - - - - - - - - - - - - A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. - intraflagellar transport complex - intraflagellar transport particle - cellular_component - IFT complex - GO:0030990 - - Note that we deem cilia and microtubule-based flagella to be equivalent. - intraciliary transport particle - - - - - A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. - GOC:cilia - GOC:kmv - PMID:14570576 - PMID:22118932 - PMID:23945166 - - - - - - - - - - - A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. - GO:0005578 - NIF_Subcellular:nlx_subcell_20090513 - Wikipedia:Extracellular_matrix - proteinaceous extracellular matrix - matrisome - cellular_component - GO:0031012 - - - - - - extracellular matrix - - - - - A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. - GOC:BHF - GOC:mah - GOC:rph - NIF_Subcellular:nlx_subcell_20090513 - PMID:21123617 - PMID:28089324 - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones. - https://github.com/geneontology/go-ontology/issues/23777 - Wikipedia:Pancreas - biological_process - GO:0031016 - pancreas development - - - - - The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones. - GOC:cvs - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells. - biological_process - GO:0031017 - exocrine pancreas development - - - - - The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells. - GOC:cvs - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. - biological_process - GO:0031018 - endocrine pancreas development - - - - - The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. - GOC:cvs - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins. - nuclear migration, microfilament-mediated - biological_process - GO:0031022 - nuclear migration along microfilament - - - - - The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. - actomyosin organization - actomyosin structure organisation - biological_process - actomyosin structure organization and biogenesis - GO:0031032 - Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins. - actomyosin structure organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. - GOC:dph - GOC:jl - GOC:mah - - - - - actomyosin structure organization and biogenesis - GOC:mah - - - - - - - - - Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. - NIF_Subcellular:sao772007592 - dense core vesicle - cellular_component - GO:0031045 - dense core granule - - - - - Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. - NIF_Subcellular:sao772007592 - PMID:14690495 - - - - - dense core vesicle - GOC:kmv - - - - - - - - - - - The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. - embryonic eye development - biological_process - GO:0031076 - embryonic camera-type eye development - - - - - The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. - GOC:mah - GOC:mtg_sensu - - - - - - - - - - - - - - - - - - - - - - - - - - A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. - NIF_Subcellular:sao830981606 - cellular_component - intracellular membrane - GO:0031090 - organelle membrane - - - - - A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. - GOC:dos - GOC:mah - - - - - intracellular membrane - NIF_Subcellular:sao830981606 - - - - - - - - - Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. - https://github.com/geneontology/go-ontology/issues/23195 - microtubule dynamics - biological_process - GO:0031109 - microtubule polymerization or depolymerization - - - - - Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. - biological_process - GO:0031110 - regulation of microtubule polymerization or depolymerization - - - - - Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization. - down regulation of microtubule polymerization or depolymerization - down-regulation of microtubule polymerization or depolymerization - downregulation of microtubule polymerization or depolymerization - inhibition of microtubule polymerization or depolymerization - biological_process - GO:0031111 - negative regulation of microtubule polymerization or depolymerization - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. - up regulation of microtubule polymerization or depolymerization - up-regulation of microtubule polymerization or depolymerization - upregulation of microtubule polymerization or depolymerization - activation of microtubule polymerization or depolymerization - stimulation of microtubule polymerization or depolymerization - biological_process - GO:0031112 - positive regulation of microtubule polymerization or depolymerization - - - - - Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of microtubule polymerization. - biological_process - GO:0031113 - regulation of microtubule polymerization - - - - - Any process that modulates the frequency, rate or extent of microtubule polymerization. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of microtubule depolymerization. - regulation of microtubule disassembly - biological_process - GO:0031114 - regulation of microtubule depolymerization - - - - - Any process that modulates the frequency, rate or extent of microtubule depolymerization. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization. - down regulation of microtubule polymerization - down-regulation of microtubule polymerization - downregulation of microtubule polymerization - inhibition of microtubule polymerization - biological_process - GO:0031115 - negative regulation of microtubule polymerization - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of microtubule polymerization. - up regulation of microtubule polymerization - up-regulation of microtubule polymerization - upregulation of microtubule polymerization - activation of microtubule polymerization - stimulation of microtubule polymerization - biological_process - GO:0031116 - positive regulation of microtubule polymerization - - - - - Any process that activates or increases the frequency, rate or extent of microtubule polymerization. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of microtubule depolymerization. - microtubule destabilization - positive regulation of microtubule disassembly - up regulation of microtubule depolymerization - up-regulation of microtubule depolymerization - upregulation of microtubule depolymerization - activation of microtubule depolymerization - positive regulation of microtubule catastrophe - stimulation of microtubule depolymerization - biological_process - GO:0031117 - positive regulation of microtubule depolymerization - - - - - Any process that activates or increases the frequency, rate or extent of microtubule depolymerization. - GOC:mah - - - - - positive regulation of microtubule catastrophe - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. - cytoplasmic microtubule organisation - biological_process - cytoplasmic microtubule organization and biogenesis - GO:0031122 - cytoplasmic microtubule organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. - GOC:mah - - - - - cytoplasmic microtubule organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). - - biological_process - GO:0031128 - developmental induction - - - - - A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). - GOC:cjm - GOC:dph - GOC:mah - PMID:24503535 - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). - neurite biosynthesis - neurite development - neurite formation - neurite growth - neurite outgrowth - biological_process - GO:0031175 - neuron projection development - - - - - The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). - GOC:mah - - - - - neurite development - GOC:dph - - - - - - - - - - - - - - - The area of a motile cell closest to the direction of movement. - front of cell - leading edge of cell - cellular_component - GO:0031252 - - cell leading edge - - - - - The area of a motile cell closest to the direction of movement. - GOC:pg - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. - cellular_component - membrane extension - membrane projection - GO:0031253 - cell projection membrane - - - - - The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. - GOC:krc - GOC:mah - - - - - - - - - - - - - - - - - - - - - The portion of the plasma membrane surrounding the leading edge of a motile cell. - cellular_component - GO:0031256 - leading edge membrane - - - - - The portion of the plasma membrane surrounding the leading edge of a motile cell. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. - regulation of cellular metabolism - biological_process - GO:0031323 - - regulation of cellular metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. - down regulation of cellular metabolic process - down-regulation of cellular metabolic process - downregulation of cellular metabolic process - negative regulation of cellular metabolism - inhibition of cellular metabolic process - biological_process - GO:0031324 - - negative regulation of cellular metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. - positive regulation of cellular metabolism - up regulation of cellular metabolic process - up-regulation of cellular metabolic process - upregulation of cellular metabolic process - activation of cellular metabolic process - stimulation of cellular metabolic process - biological_process - GO:0031325 - - positive regulation of cellular metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. - regulation of cellular anabolism - regulation of cellular biosynthesis - regulation of cellular formation - regulation of cellular synthesis - biological_process - GO:0031326 - regulation of cellular biosynthetic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. - down regulation of cellular biosynthetic process - down-regulation of cellular biosynthetic process - downregulation of cellular biosynthetic process - negative regulation of cellular anabolism - negative regulation of cellular biosynthesis - negative regulation of cellular formation - negative regulation of cellular synthesis - inhibition of cellular biosynthetic process - biological_process - GO:0031327 - negative regulation of cellular biosynthetic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. - positive regulation of cellular anabolism - positive regulation of cellular biosynthesis - positive regulation of cellular formation - positive regulation of cellular synthesis - up regulation of cellular biosynthetic process - up-regulation of cellular biosynthetic process - upregulation of cellular biosynthetic process - activation of cellular biosynthetic process - stimulation of cellular biosynthetic process - biological_process - GO:0031328 - positive regulation of cellular biosynthetic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. - regulation of cellular breakdown - regulation of cellular catabolism - regulation of cellular degradation - biological_process - GO:0031329 - regulation of cellular catabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. - down regulation of cellular catabolic process - down-regulation of cellular catabolic process - downregulation of cellular catabolic process - negative regulation of cellular breakdown - negative regulation of cellular catabolism - negative regulation of cellular degradation - inhibition of cellular catabolic process - biological_process - GO:0031330 - negative regulation of cellular catabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. - positive regulation of cellular breakdown - positive regulation of cellular catabolism - positive regulation of cellular degradation - up regulation of cellular catabolic process - up-regulation of cellular catabolic process - upregulation of cellular catabolic process - activation of cellular catabolic process - stimulation of cellular catabolic process - biological_process - GO:0031331 - positive regulation of cellular catabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. - down regulation of protein complex assembly - down-regulation of protein complex assembly - downregulation of protein complex assembly - inhibition of protein complex assembly - biological_process - negative regulation of protein complex assembly - GO:0031333 - negative regulation of protein-containing complex assembly - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of protein complex assembly. - up regulation of protein complex assembly - up-regulation of protein complex assembly - upregulation of protein complex assembly - activation of protein complex assembly - stimulation of protein complex assembly - biological_process - positive regulation of protein complex assembly - GO:0031334 - positive regulation of protein-containing complex assembly - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of protein complex assembly. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of vesicle fusion. - biological_process - GO:0031338 - regulation of vesicle fusion - - - - - Any process that modulates the frequency, rate or extent of vesicle fusion. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion. - down regulation of vesicle fusion - down-regulation of vesicle fusion - downregulation of vesicle fusion - inhibition of vesicle fusion - biological_process - GO:0031339 - negative regulation of vesicle fusion - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of vesicle fusion. - up regulation of vesicle fusion - up-regulation of vesicle fusion - upregulation of vesicle fusion - activation of vesicle fusion - stimulation of vesicle fusion - biological_process - GO:0031340 - positive regulation of vesicle fusion - - - - - Any process that activates or increases the frequency, rate or extent of vesicle fusion. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. - regulation of cell projection organisation - biological_process - regulation of cell projection organization and biogenesis - GO:0031344 - regulation of cell projection organization - - - - - Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. - GOC:mah - - - - - regulation of cell projection organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. - down regulation of cell projection organization - down-regulation of cell projection organization - downregulation of cell projection organization - negative regulation of cell projection organisation - inhibition of cell projection organization - biological_process - negative regulation of cell projection organization and biogenesis - GO:0031345 - negative regulation of cell projection organization - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. - GOC:mah - - - - - down regulation of cell projection organization - GOC:mah - - - - - negative regulation of cell projection organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. - positive regulation of cell projection organisation - up regulation of cell projection organization - up-regulation of cell projection organization - upregulation of cell projection organization - activation of cell projection organization - stimulation of cell projection organization - biological_process - positive regulation of cell projection organization and biogenesis - GO:0031346 - positive regulation of cell projection organization - - - - - Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. - GOC:mah - - - - - positive regulation of cell projection organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A vesicle found in the cytoplasm of a cell. - GO:0016023 - NIF_Subcellular:sao180601769 - cellular_component - cytoplasmic membrane bounded vesicle - cytoplasmic membrane-enclosed vesicle - cytoplasmic, membrane-bounded vesicle - GO:0031410 - - - - - - - cytoplasmic vesicle - - - - - A vesicle found in the cytoplasm of a cell. - GOC:ai - GOC:mah - GOC:vesicles - - - - - - - - - - - - - - - - - - - - - - - - - - A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. - https://github.com/geneontology/go-ontology/issues/22021 - GO:0034629 - establishment and maintenance of protein complex localization - protein complex localisation - biological_process - cellular protein complex localisation - cellular protein complex localization - cellular protein-containing complex localization - establishment and maintenance of cellular protein complex localization - protein complex localization - GO:0031503 - protein-containing complex localization - - - - - A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. - GOC:mah - - - - - protein complex localisation - GOC:mah - - - - - cellular protein complex localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. - NIF_Subcellular:sao1124888485 - Wikipedia:Neuromuscular_junction - cellular_component - NMJ - motor endplate - GO:0031594 - In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT. - neuromuscular junction - - - - - The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. - GOC:nln - - - - - NMJ - GOC:ha - - - - - motor endplate - NIF_Subcellular:nlx_subcell_20090512 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. - regulation of neurological process - regulation of neurological system process - regulation of neurophysiological process - biological_process - GO:0031644 - regulation of nervous system process - - - - - Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. - GOC:dph - GOC:mah - GOC:tb - - - - - regulation of neurological process - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. - down regulation of neurological process - down-regulation of neurological process - downregulation of neurological process - negative regulation of neurological process - negative regulation of neurological system process - negative regulation of neurophysiological process - inhibition of neurological process - biological_process - GO:0031645 - negative regulation of nervous system process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. - GOC:dph - GOC:mah - GOC:tb - - - - - negative regulation of neurological process - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of a neurophysiological process. - positive regulation of neurological process - positive regulation of neurological system process - positive regulation of neurophysiological process - up regulation of neurological process - up-regulation of neurological process - upregulation of neurological process - activation of neurological process - stimulation of neurological process - biological_process - GO:0031646 - positive regulation of nervous system process - - - - - Any process that activates or increases the frequency, rate or extent of a neurophysiological process. - GOC:dph - GOC:mah - GOC:tb - - - - - positive regulation of neurological process - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. - NIF_Subcellular:sao1687101204 - cellular_component - GO:0031965 - nuclear membrane - - - - - Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. - GOC:mah - GOC:pz - - - - - - - - - - - - - - - - - - - - - A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. - cellular_component - GO:0031967 - - organelle envelope - - - - - A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. - GOC:mah - GOC:pz - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope. - cellular_component - GO:0031968 - organelle outer membrane - - - - - The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope. - GOC:mah - - - - - - - - - - The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen. - cellular_component - GO:0031974 - membrane-enclosed lumen - - - - - The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen. - GOC:add - GOC:mah - - - - - - - - - - - - - - - A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. - cellular_component - GO:0031975 - envelope - - - - - A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. - GOC:mah - GOC:pz - - - - - - - - - - - - - - - The volume enclosed by the nuclear inner membrane. - cellular_component - GO:0031981 - nuclear lumen - - - - - The volume enclosed by the nuclear inner membrane. - GOC:mah - GOC:pz - - - - - - - - - Any small, fluid-filled, spherical organelle enclosed by membrane. - GO:0031988 - NIF_Subcellular:sao221389602 - Wikipedia:Vesicle_(biology) - cellular_component - membrane-bounded vesicle - membrane-enclosed vesicle - GO:0031982 - - vesicle - - - - - Any small, fluid-filled, spherical organelle enclosed by membrane. - GOC:mah - GOC:pz - GOC:vesicles - - - - - - - - - - - - - - - - - - - - - - - - - - Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. - locomotion during locomotory behaviour - biological_process - GO:0031987 - locomotion involved in locomotory behavior - - - - - Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. - up regulation of insulin secretion - up-regulation of insulin secretion - upregulation of insulin secretion - activation of insulin secretion - stimulation of insulin secretion - biological_process - GO:0032024 - positive regulation of insulin secretion - - - - - Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress. - down regulation of translation initiation in response to stress - down-regulation of translation initiation in response to stress - downregulation of translation initiation in response to stress - inhibition of translation initiation in response to stress - biological_process - GO:0032057 - negative regulation of translational initiation in response to stress - - - - - Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress. - up regulation of translation initiation in response to stress - up-regulation of translation initiation in response to stress - upregulation of translation initiation in response to stress - activation of translation initiation in response to stress - stimulation of translation initiation in response to stress - biological_process - GO:0032058 - positive regulation of translational initiation in response to stress - - - - - Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress. - GOC:mah - - - - - - - - - A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. - Wikipedia:Bleb_(cell_biology) - plasma membrane bleb - cellular_component - GO:0032059 - - bleb - - - - - A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. - GOC:mtg_apoptosis - PMID:12083798 - PMID:16624291 - Wikipedia:Bleb_(cell_biology) - - - - - plasma membrane bleb - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. - blebbing - membrane blebbing - cell blebbing - plasma membrane bleb assembly - plasma membrane blebbing - biological_process - GO:0032060 - bleb assembly - - - - - The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. - GOC:mah - GOC:mtg_apoptosis - PMID:12083798 - PMID:16624291 - Wikipedia:Bleb_(cell_biology) - - - - - blebbing - GOC:pr - - - - - membrane blebbing - GOC:pr - - - - - plasma membrane bleb assembly - GOC:pr - - - - - plasma membrane blebbing - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. - biological_process - nuclease regulator activity - GO:0032069 - - regulation of nuclease activity - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. - biological_process - DNase regulator - deoxyribonuclease regulator - GO:0032070 - - regulation of deoxyribonuclease activity - - - - - Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids. - down regulation of nuclease activity - down-regulation of nuclease activity - downregulation of nuclease activity - inhibition of nuclease activity - biological_process - nuclease inhibitor - GO:0032074 - - negative regulation of nuclease activity - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. - up regulation of nuclease activity - up-regulation of nuclease activity - upregulation of nuclease activity - activation of nuclease activity - stimulation of nuclease activity - biological_process - nuclease activator - GO:0032075 - - positive regulation of nuclease activity - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. - down regulation of deoxyribonuclease activity - down-regulation of deoxyribonuclease activity - downregulation of deoxyribonuclease activity - inhibition of deoxyribonuclease activity - biological_process - DNase inhibitor - deoxyribonuclease inhibitor - GO:0032076 - - negative regulation of deoxyribonuclease activity - - - - - Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. - up regulation of deoxyribonuclease activity - up-regulation of deoxyribonuclease activity - upregulation of deoxyribonuclease activity - activation of deoxyribonuclease activity - stimulation of deoxyribonuclease activity - biological_process - DNase activator - deoxyribonuclease activator - GO:0032077 - - positive regulation of deoxyribonuclease activity - - - - - Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a response to an external stimulus. - biological_process - GO:0032101 - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - regulation of response to external stimulus - - - - - Any process that modulates the frequency, rate or extent of a response to an external stimulus. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. - down regulation of response to external stimulus - down-regulation of response to external stimulus - downregulation of response to external stimulus - inhibition of response to external stimulus - biological_process - GO:0032102 - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - negative regulation of response to external stimulus - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the rate of a response to an external stimulus. - up regulation of response to external stimulus - up-regulation of response to external stimulus - upregulation of response to external stimulus - activation of response to external stimulus - stimulation of response to external stimulus - biological_process - GO:0032103 - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - positive regulation of response to external stimulus - - - - - Any process that activates, maintains or increases the rate of a response to an external stimulus. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The lipid bilayer surrounding a dense core granule. - dense core vesicle membrane - cellular_component - GO:0032127 - dense core granule membrane - - - - - The lipid bilayer surrounding a dense core granule. - GOC:mah - - - - - dense core vesicle membrane - GOC:kmv - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. - biological_process - GO:0032222 - regulation of synaptic transmission, cholinergic - - - - - Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. - down regulation of synaptic transmission, cholinergic - down-regulation of synaptic transmission, cholinergic - downregulation of synaptic transmission, cholinergic - inhibition of synaptic transmission, cholinergic - biological_process - GO:0032223 - negative regulation of synaptic transmission, cholinergic - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. - up regulation of synaptic transmission, cholinergic - up-regulation of synaptic transmission, cholinergic - upregulation of synaptic transmission, cholinergic - activation of synaptic transmission, cholinergic - stimulation of synaptic transmission, cholinergic - biological_process - GO:0032224 - positive regulation of synaptic transmission, cholinergic - - - - - Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. - regulation of actin cable assembly - biological_process - regulation of actin filament bundle formation - GO:0032231 - regulation of actin filament bundle assembly - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. - GOC:mah - - - - - regulation of actin cable assembly - GOC:dph - GOC:tb - - - - - regulation of actin filament bundle formation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. - down regulation of actin filament bundle formation - down-regulation of actin filament bundle formation - downregulation of actin filament bundle formation - inhibition of actin filament bundle formation - biological_process - GO:0032232 - negative regulation of actin filament bundle assembly - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. - up regulation of actin filament bundle formation - up-regulation of actin filament bundle formation - upregulation of actin filament bundle formation - activation of actin filament bundle formation - stimulation of actin filament bundle formation - biological_process - GO:0032233 - positive regulation of actin filament bundle assembly - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport - GO:0032239 - regulation of nucleobase-containing compound transport - - - - - Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:mah - - - - - regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport - down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport - downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport - inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport - biological_process - negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport - GO:0032240 - negative regulation of nucleobase-containing compound transport - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:mah - - - - - negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport - up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport - upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport - activation of nucleobase, nucleoside, nucleotide and nucleic acid transport - stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport - biological_process - positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport - GO:0032241 - positive regulation of nucleobase-containing compound transport - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:mah - - - - - positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell. - secretory granule localisation - biological_process - secretory granule clustering - GO:0032252 - secretory granule localization - - - - - Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell. - GOC:mah - - - - - secretory granule localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell. - dense core granule localisation - dense core vesicle localization - biological_process - dense core granule clustering - GO:0032253 - dense core granule localization - - - - - Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell. - GOC:mah - - - - - dense core granule localisation - GOC:mah - - - - - dense core vesicle localization - GOC:kmv - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the process of creating protein polymers. - regulation of protein polymerisation - biological_process - GO:0032271 - regulation of protein polymerization - - - - - Any process that modulates the frequency, rate or extent of the process of creating protein polymers. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers. - down regulation of protein polymerization - down-regulation of protein polymerization - downregulation of protein polymerization - inhibition of protein polymerization - biological_process - GO:0032272 - negative regulation of protein polymerization - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. - up regulation of protein polymerization - up-regulation of protein polymerization - upregulation of protein polymerization - activation of protein polymerization - stimulation of protein polymerization - biological_process - GO:0032273 - positive regulation of protein polymerization - - - - - Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of chondrocyte differentiation. - biological_process - GO:0032330 - regulation of chondrocyte differentiation - - - - - Any process that modulates the frequency, rate or extent of chondrocyte differentiation. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. - down regulation of chondrocyte differentiation - down-regulation of chondrocyte differentiation - downregulation of chondrocyte differentiation - inhibition of chondrocyte differentiation - biological_process - GO:0032331 - negative regulation of chondrocyte differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. - up regulation of chondrocyte differentiation - up-regulation of chondrocyte differentiation - upregulation of chondrocyte differentiation - activation of chondrocyte differentiation - stimulation of chondrocyte differentiation - biological_process - GO:0032332 - positive regulation of chondrocyte differentiation - - - - - Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of lipids within cells. - biological_process - GO:0032365 - intracellular lipid transport - - - - - The directed movement of lipids within cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0032368 - regulation of lipid transport - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - down regulation of lipid transport - down-regulation of lipid transport - downregulation of lipid transport - inhibition of lipid transport - biological_process - GO:0032369 - negative regulation of lipid transport - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - up regulation of lipid transport - up-regulation of lipid transport - upregulation of lipid transport - activation of lipid transport - stimulation of lipid transport - biological_process - GO:0032370 - positive regulation of lipid transport - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells. - biological_process - GO:0032377 - regulation of intracellular lipid transport - - - - - Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells. - down regulation of intracellular lipid transport - down-regulation of intracellular lipid transport - downregulation of intracellular lipid transport - inhibition of intracellular lipid transport - biological_process - GO:0032378 - negative regulation of intracellular lipid transport - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells. - up regulation of intracellular lipid transport - up-regulation of intracellular lipid transport - upregulation of intracellular lipid transport - activation of intracellular lipid transport - stimulation of intracellular lipid transport - biological_process - GO:0032379 - positive regulation of intracellular lipid transport - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. - biological_process - GO:0032386 - regulation of intracellular transport - - - - - Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. - down regulation of intracellular transport - down-regulation of intracellular transport - downregulation of intracellular transport - inhibition of intracellular transport - biological_process - GO:0032387 - negative regulation of intracellular transport - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. - up regulation of intracellular transport - up-regulation of intracellular transport - upregulation of intracellular transport - activation of intracellular transport - stimulation of intracellular transport - biological_process - GO:0032388 - positive regulation of intracellular transport - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the activity of a transporter. - biological_process - GO:0032409 - - regulation of transporter activity - - - - - Any process that modulates the activity of a transporter. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops or reduces the activity of a transporter. - down regulation of transporter activity - down-regulation of transporter activity - downregulation of transporter activity - inhibition of transporter activity - biological_process - GO:0032410 - - negative regulation of transporter activity - - - - - Any process that stops or reduces the activity of a transporter. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the activity of a transporter. - up regulation of transporter activity - up-regulation of transporter activity - upregulation of transporter activity - activation of transporter activity - stimulation of transporter activity - biological_process - GO:0032411 - - positive regulation of transporter activity - - - - - Any process that activates or increases the activity of a transporter. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the activity of an ion transporter. - regulation of ion transmembrane transporter activity - regulation of ion transporter activity - biological_process - GO:0032412 - - regulation of monoatomic ion transmembrane transporter activity - - - - - Any process that modulates the activity of an ion transporter. - GOC:mah - GOC:tb - - - - - regulation of ion transporter activity - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops or reduces the activity of an ion transporter. - down regulation of ion transporter activity - down-regulation of ion transporter activity - downregulation of ion transporter activity - negative regulation of ion transporter activity - inhibition of ion transporter activity - biological_process - GO:0032413 - - negative regulation of ion transmembrane transporter activity - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops or reduces the activity of an ion transporter. - GOC:mah - GOC:tb - - - - - negative regulation of ion transporter activity - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the activity of an ion transporter. - positive regulation of ion transporter activity - up regulation of ion transporter activity - up-regulation of ion transporter activity - upregulation of ion transporter activity - activation of ion transporter activity - stimulation of ion transporter activity - biological_process - GO:0032414 - - positive regulation of ion transmembrane transporter activity - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the activity of an ion transporter. - GOC:mah - GOC:tb - - - - - positive regulation of ion transporter activity - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. - GO:0000141 - GO:0030482 - cellular_component - actin cable - GO:0032432 - actin filament bundle - - - - - An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. - GOC:mah - - - - - actin cable - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any biological process, occurring at the level of a multicellular organism, pertinent to its function. - - - - - jl - 2012-09-19T16:07:47Z - GO:0044707 - GO:0050874 - organismal physiological process - biological_process - single-multicellular organism process - GO:0032501 - - - multicellular organismal process - - - - - Any biological process, occurring at the level of a multicellular organism, pertinent to its function. - GOC:curators - GOC:dph - GOC:isa_complete - GOC:tb - - - - - - - - - A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. - jl - 2012-12-19T12:21:31Z - GO:0044767 - development - biological_process - single-organism developmental process - GO:0032502 - - - - developmental process - - - - - A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. - GOC:isa_complete - - - - - - - - - - The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. - biological_process - GO:0032504 - - multicellular organism reproduction - - - - - The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. - GOC:isa_complete - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. - - microvillus organisation - biological_process - microvillus organization and biogenesis - GO:0032528 - microvillus organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. - GOC:mah - - - - - microvillus organisation - GOC:mah - - - - - microvillus organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. - regulation of microvillus organisation - biological_process - regulation of microvillus organization and biogenesis - GO:0032530 - regulation of microvillus organization - - - - - Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. - GOC:mah - - - - - regulation of microvillus organisation - GOC:mah - - - - - regulation of microvillus organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that modulates the formation of a microvillus. - biological_process - regulation of microvillus biogenesis - GO:0032534 - regulation of microvillus assembly - - - - - A process that modulates the formation of a microvillus. - GOC:mah - - - - - regulation of microvillus biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The portion of the plasma membrane surrounding a neuron projection. - cellular_component - GO:0032589 - neuron projection membrane - - - - - The portion of the plasma membrane surrounding a neuron projection. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a protein from one location to another within a lipid bilayer. - protein translocation within membrane - receptor translocation within membrane - receptor transport within lipid bilayer - biological_process - GO:0032594 - protein transport within lipid bilayer - - - - - The directed movement of a protein from one location to another within a lipid bilayer. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication. - GO:0062103 - RNA anabolism - RNA biosynthesis - RNA formation - RNA synthesis - double-stranded RNA biosynthesis - double-stranded RNA biosynthetic process - dsRNA biosynthesis - dsRNA biosynthetic process - biological_process - GO:0032774 - - Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. - RNA biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication. - GOC:mah - GOC:txnOH - - - - - dsRNA biosynthetic process - GOC:BHF - GOC:BHF_telomere - GOC:nc - GOC:rl - - - - - - - - - - - - - - - - - - - - - - - - - - - The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue. - biological_process - GO:0032782 - bile acid secretion - - - - - The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue. - GOC:ecd - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). - monocarboxylate metabolic process - monocarboxylic acid metabolism - biological_process - GO:0032787 - - monocarboxylic acid metabolic process - - - - - The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). - GOC:vk - - - - - - - - - - - - - - - - - - - - - - - - - - The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits. - ribosome recycling - biological_process - ribosome dissociation factor - GO:0032790 - ribosome disassembly - - - - - The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits. - GOC:mah - GOC:vk - - - - - ribosome recycling - GOC:db - PMID:9463391 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection. - cellular_component - GO:0032838 - plasma membrane bounded cell projection cytoplasm - - - - - All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection. - GOC:krc - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. - response to insulin stimulus - biological_process - GO:0032868 - response to insulin - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. - GOC:mah - ISBN:0198506732 - - - - - response to insulin stimulus - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion. - biological_process - GO:0032871 - regulation of karyogamy - - - - - Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. - biological_process - GO:0032878 - regulation of establishment or maintenance of cell polarity - - - - - Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. - regulation of localisation - biological_process - GO:0032879 - regulation of localization - - - - - Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. - GOC:mah - - - - - regulation of localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. - https://github.com/geneontology/go-ontology/issues/22021 - jl - 2015-01-20T14:32:14Z - GO:1903827 - regulation of cellular protein localisation - regulation of cellular protein localization - regulation of protein localisation - biological_process - GO:0032880 - - regulation of protein localization - - - - - Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. - GOC:dph - GOC:mah - GOC:tb - - - - - regulation of cellular protein localisation - GOC:TermGenie - - - - - regulation of protein localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. - biological_process - GO:0032881 - regulation of polysaccharide metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides. - biological_process - GO:0032885 - regulation of polysaccharide biosynthetic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. - biological_process - GO:0032886 - regulation of microtubule-based process - - - - - Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0032890 - regulation of organic acid transport - - - - - Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - down regulation of organic acid transport - down-regulation of organic acid transport - downregulation of organic acid transport - inhibition of organic acid transport - biological_process - GO:0032891 - negative regulation of organic acid transport - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - up regulation of organic acid transport - up-regulation of organic acid transport - upregulation of organic acid transport - activation of organic acid transport - stimulation of organic acid transport - biological_process - GO:0032892 - positive regulation of organic acid transport - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:mah - - - - - - - - - - The controlled release of a substance by a cell. - Wikipedia:Secretion - cellular secretion - biological_process - GO:0032940 - secretion by cell - - - - - The controlled release of a substance by a cell. - GOC:mah - - - - - - - - - - The controlled release of a substance by a tissue. - tissue secretion - biological_process - expulsion of gland contents - GO:0032941 - secretion by tissue - - - - - The controlled release of a substance by a tissue. - GOC:mah - - - - - expulsion of gland contents - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form. - PBMC proliferation - peripheral blood mononuclear cell proliferation - biological_process - GO:0032943 - mononuclear cell proliferation - - - - - The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of mononuclear cell proliferation. - regulation of PBMC proliferation - regulation of peripheral blood mononuclear cell proliferation - biological_process - GO:0032944 - regulation of mononuclear cell proliferation - - - - - Any process that modulates the frequency, rate or extent of mononuclear cell proliferation. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation. - negative regulation of PBMC proliferation - negative regulation of peripheral blood mononuclear cell proliferation - biological_process - GO:0032945 - negative regulation of mononuclear cell proliferation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. - up regulation of mononuclear cell proliferation - up-regulation of mononuclear cell proliferation - upregulation of mononuclear cell proliferation - activation of mononuclear cell proliferation - positive regulation of PBMC proliferation - positive regulation of peripheral blood mononuclear cell proliferation - stimulation of mononuclear cell proliferation - biological_process - GO:0032946 - positive regulation of mononuclear cell proliferation - - - - - Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. - regulation of actin cytoskeleton organisation - biological_process - regulation of actin cytoskeleton organization and biogenesis - GO:0032956 - regulation of actin cytoskeleton organization - - - - - Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. - GOC:mah - - - - - regulation of actin cytoskeleton organisation - GOC:mah - - - - - regulation of actin cytoskeleton organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). - collagen metabolism - biological_process - GO:0032963 - collagen metabolic process - - - - - The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). - GOC:mah - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). - collagen anabolism - collagen biosynthesis - collagen formation - collagen synthesis - biological_process - GO:0032964 - collagen biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). - GOC:mah - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. - regulation of collagen anabolism - regulation of collagen biosynthesis - regulation of collagen formation - regulation of collagen synthesis - biological_process - GO:0032965 - regulation of collagen biosynthetic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. - negative regulation of collagen anabolism - negative regulation of collagen biosynthesis - negative regulation of collagen formation - negative regulation of collagen synthesis - biological_process - GO:0032966 - negative regulation of collagen biosynthetic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. - positive regulation of collagen anabolism - positive regulation of collagen biosynthesis - positive regulation of collagen formation - positive regulation of collagen synthesis - biological_process - GO:0032967 - positive regulation of collagen biosynthetic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton. - biological_process - GO:0032970 - regulation of actin filament-based process - - - - - Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The disaggregation of a protein-containing macromolecular complex into its constituent components. - https://github.com/geneontology/go-ontology/issues/22580 - GO:0034623 - GO:0043241 - GO:0043624 - protein complex disassembly - biological_process - cellular macromolecule complex disassembly - cellular protein complex disassembly - macromolecule complex disassembly - GO:0032984 - protein-containing complex disassembly - - - - - The disaggregation of a protein-containing macromolecular complex into its constituent components. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The disaggregation of a protein-DNA complex into its constituent components. - DNA-protein complex disassembly - biological_process - GO:0032986 - protein-DNA complex disassembly - - - - - The disaggregation of a protein-DNA complex into its constituent components. - GOC:mah - - - - - DNA-protein complex disassembly - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The disaggregation of a protein-RNA complex into its constituent components. - https://github.com/geneontology/go-ontology/issues/25143 - RNA-protein complex disassembly - RNP complex disassembly - ribonucleoprotein complex disassembly - biological_process - GO:0032988 - protein-RNA complex disassembly - - - - - The disaggregation of a protein-RNA complex into its constituent components. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which cellular structures, including whole cells or cell parts, are generated and organized. - https://github.com/geneontology/go-ontology/issues/25496 - cellular structure morphogenesis - biological_process - GO:0032989 - - cellular component morphogenesis - - - - - The process in which cellular structures, including whole cells or cell parts, are generated and organized. - GOC:dph - GOC:mah - GOC:tb - - - - - cellular structure morphogenesis - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of a cell part are generated and organized. - biological_process - GO:0032990 - cell part morphogenesis - - - - - The process in which the anatomical structures of a cell part are generated and organized. - GOC:mah - - - - - - - - - - - - - - - - - A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. - GO:0043234 - macromolecular complex - macromolecule complex - protein containing complex - protein complex - protein-protein complex - cellular_component - GO:0032991 - - - - - - A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. - protein-containing complex - - - - - A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. - GOC:dos - GOC:mah - - - - - - - - - - - - - - - - - - - - - A macromolecular complex containing both protein and DNA molecules. - DNA-protein complex - cellular_component - GO:0032993 - - Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here. - protein-DNA complex - - - - - A macromolecular complex containing both protein and DNA molecules. - GOC:mah - - - - - DNA-protein complex - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The expansion of a muscle cell population by cell division. - myocyte proliferation - biological_process - GO:0033002 - muscle cell proliferation - - - - - The expansion of a muscle cell population by cell division. - CL:0000187 - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. - tetrapyrrole metabolism - biological_process - GO:0033013 - - - tetrapyrrole metabolic process - - - - - The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. - tetrapyrrole anabolism - tetrapyrrole biosynthesis - tetrapyrrole formation - tetrapyrrole synthesis - biological_process - GO:0033014 - tetrapyrrole biosynthetic process - - - - - The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. - tetrapyrrole breakdown - tetrapyrrole catabolism - tetrapyrrole degradation - biological_process - GO:0033015 - tetrapyrrole catabolic process - - - - - The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. - apoptosis of myeloid cells - myeloid cell apoptosis - biological_process - GO:0033028 - myeloid cell apoptotic process - - - - - Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. - CL:0000763 - GOC:add - GOC:mtg_apoptosis - PMID:11292031 - PMID:15330259 - PMID:17133093 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. - regulation of myeloid cell apoptosis - biological_process - GO:0033032 - regulation of myeloid cell apoptotic process - - - - - Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. - GOC:add - GOC:mtg_apoptosis - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process. - down regulation of myeloid cell apoptosis - down-regulation of myeloid cell apoptosis - downregulation of myeloid cell apoptosis - inhibition of myeloid cell apoptosis - negative regulation of myeloid cell apoptosis - biological_process - GO:0033033 - negative regulation of myeloid cell apoptotic process - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process. - GOC:add - GOC:mtg_apoptosis - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process. - up regulation of myeloid cell apoptosis - up-regulation of myeloid cell apoptosis - upregulation of myeloid cell apoptosis - activation of myeloid cell apoptosis - positive regulation of myeloid cell apoptosis - stimulation of myeloid cell apoptosis - biological_process - GO:0033034 - positive regulation of myeloid cell apoptotic process - - - - - Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process. - GOC:add - GOC:mtg_apoptosis - - - - - - - - - Any process in which a macromolecule is transported to, or maintained in, a specific location. - macromolecule localisation - biological_process - GO:0033036 - - macromolecule localization - - - - - Any process in which a macromolecule is transported to, or maintained in, a specific location. - GOC:mah - - - - - macromolecule localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a polysaccharide is transported to, or maintained in, a specific location. - polysaccharide localisation - biological_process - GO:0033037 - polysaccharide localization - - - - - Any process in which a polysaccharide is transported to, or maintained in, a specific location. - GOC:mah - - - - - polysaccharide localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. - regulation of organelle organisation - biological_process - regulation of organelle organization and biogenesis - GO:0033043 - - regulation of organelle organization - - - - - Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. - GOC:mah - - - - - regulation of organelle organisation - GOC:mah - - - - - regulation of organelle organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. - regulation of chromosome organisation - biological_process - regulation of chromosome organization and biogenesis - GO:0033044 - regulation of chromosome organization - - - - - Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. - GOC:mah - - - - - regulation of chromosome organisation - GOC:mah - - - - - regulation of chromosome organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of sister chromatid segregation. - biological_process - GO:0033045 - regulation of sister chromatid segregation - - - - - Any process that modulates the frequency, rate or extent of sister chromatid segregation. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation. - biological_process - GO:0033046 - negative regulation of sister chromatid segregation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis. - biological_process - GO:0033047 - regulation of mitotic sister chromatid segregation - - - - - Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis. - biological_process - GO:0033048 - negative regulation of mitotic sister chromatid segregation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis. - GOC:mah - - - - - - - - - - The deposition or aggregation of coloring matter in a cell. - biological_process - GO:0033059 - cellular pigmentation - - - - - The deposition or aggregation of coloring matter in a cell. - GOC:mtg_MIT_16mar07 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. - biological_process - GO:0033157 - regulation of intracellular protein transport - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. - regulation of amine metabolism - regulation of cellular amine metabolic process - biological_process - GO:0033238 - regulation of amine metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines. - negative regulation of amine metabolism - negative regulation of cellular amine metabolic process - biological_process - GO:0033239 - negative regulation of amine metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. - positive regulation of amine metabolism - positive regulation of cellular amine metabolic process - biological_process - GO:0033240 - positive regulation of amine metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. - regulation of amine breakdown - regulation of amine catabolism - regulation of amine degradation - regulation of cellular amine catabolic process - biological_process - GO:0033241 - regulation of amine catabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. - negative regulation of amine breakdown - negative regulation of amine catabolism - negative regulation of amine degradation - negative regulation of cellular amine catabolic process - biological_process - GO:0033242 - negative regulation of amine catabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. - positive regulation of amine breakdown - positive regulation of amine catabolism - positive regulation of amine degradation - biological_process - GO:0033243 - positive regulation of amine catabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain. - cell proliferation in mesencephalon - biological_process - mesencepahalic cell proliferation - GO:0033278 - cell proliferation in midbrain - - - - - The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain. - GOC:dgf - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. - secretory granule organisation - biological_process - secretory granule organization and biogenesis - GO:0033363 - secretory granule organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. - GOC:mah - - - - - secretory granule organisation - GOC:mah - - - - - secretory granule organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, a location within an organelle. - protein localisation to organelle - protein localization in organelle - biological_process - GO:0033365 - protein localization to organelle - - - - - A process in which a protein is transported to, or maintained in, a location within an organelle. - GOC:mah - - - - - protein localisation to organelle - GOC:mah - - - - - protein localization in organelle - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, a location within a secretory granule. - protein localisation in secretory granule - protein localization in secretory granule - biological_process - GO:0033366 - protein localization to secretory granule - - - - - A process in which a protein is transported to, or maintained in, a location within a secretory granule. - GOC:mah - - - - - protein localisation in secretory granule - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. - down regulation of catecholamine secretion - down-regulation of catecholamine secretion - downregulation of catecholamine secretion - inhibition of catecholamine secretion - biological_process - GO:0033604 - negative regulation of catecholamine secretion - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. - up regulation of catecholamine secretion - up-regulation of catecholamine secretion - upregulation of catecholamine secretion - activation of catecholamine secretion - stimulation of catecholamine secretion - biological_process - GO:0033605 - positive regulation of catecholamine secretion - - - - - Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. - down regulation of kinase activity - down-regulation of kinase activity - downregulation of kinase activity - inhibition of kinase activity - kinase inhibitor - biological_process - GO:0033673 - - negative regulation of kinase activity - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. - up regulation of kinase activity - up-regulation of kinase activity - upregulation of kinase activity - kinase activator - stimulation of kinase activity - biological_process - GO:0033674 - - positive regulation of kinase activity - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a ribosome is transported to, and/or maintained in, a specific location. - GO:0033753 - biological_process - establishment of ribosome localisation - establishment of ribosome localization - ribosome localisation - GO:0033750 - ribosome localization - - - - - A process in which a ribosome is transported to, and/or maintained in, a specific location. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. - response to glucagon stimulus - biological_process - GO:0033762 - response to glucagon - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. - GOC:sl - - - - - response to glucagon stimulus - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. - biological_process - GO:0033993 - response to lipid - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. - GOC:sl - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. - mah - 2011-02-14T02:26:36Z - GO:0000042 - GO:0072600 - protein localisation in Golgi apparatus - protein localization in Golgi apparatus - establishment of protein localisation to Golgi - establishment of protein localization in Golgi - establishment of protein localization to Golgi - establishment of protein localization to Golgi apparatus - biological_process - protein targeting to Golgi - protein-Golgi targeting - GO:0034067 - protein localization to Golgi apparatus - - - - - A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. - GOC:mah - - - - - protein localisation in Golgi apparatus - GOC:mah - - - - - establishment of protein localisation to Golgi - GOC:mah - - - - - establishment of protein localization to Golgi apparatus - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process of regulating the production and elimination of erythrocytes within an organism. - RBC homeostasis - red blood cell homeostasis - biological_process - GO:0034101 - erythrocyte homeostasis - - - - - Any process of regulating the production and elimination of erythrocytes within an organism. - GOC:add - PMID:10694114 - PMID:14754397 - - - - - RBC homeostasis - CL:0000232 - - - - - red blood cell homeostasis - CL:0000232 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a carbohydrate is transported across a membrane. - carbohydrate membrane transport - transmembrane carbohydrate transport - biological_process - GO:0034219 - Note that this term is not intended for use in annotating lateral movement within membranes. - carbohydrate transmembrane transport - - - - - The process in which a carbohydrate is transported across a membrane. - GOC:mah - - - - - transmembrane carbohydrate transport - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. - GO:0099131 - ion transmembrane transport - ion membrane transport - transmembrane ion transport - ATP hydrolysis coupled ion transmembrane transport - biological_process - GO:0034220 - Note that this term is not intended for use in annotating lateral movement within membranes. - monoatomic ion transmembrane transport - - - - - A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. - GOC:mah - - - - - transmembrane ion transport - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. - biological_process - GO:0034242 - negative regulation of syncytium formation by plasma membrane fusion - - - - - Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. - regulation of amide metabolism - regulation of cellular amide metabolic process - biological_process - GO:0034248 - regulation of amide metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. - negative regulation of amide metabolism - negative regulation of cellular amide metabolic process - biological_process - GO:0034249 - negative regulation of amide metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. - positive regulation of amide metabolism - positive regulation of cellular amide metabolic process - biological_process - GO:0034250 - positive regulation of amide metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. - regulation of amide breakdown - regulation of amide catabolism - regulation of amide degradation - regulation of cellular amide catabolic process - biological_process - GO:0034251 - regulation of amide catabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. - negative regulation of amide breakdown - negative regulation of amide catabolism - negative regulation of cellular amide catabolic process - biological_process - negative regulation of amide degradation - GO:0034252 - negative regulation of amide catabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. - positive regulation of amide breakdown - positive regulation of amide catabolism - positive regulation of cellular amide catabolic process - biological_process - positive regulation of amide degradation - GO:0034253 - positive regulation of amide catabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus. - response to monosaccharide stimulus - biological_process - GO:0034284 - response to monosaccharide - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus. - GOC:mah - - - - - response to monosaccharide stimulus - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. - biological_process - GO:0034329 - cell junction assembly - - - - - A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. - cell junction assembly and maintenance - cell junction organisation - biological_process - cell junction biogenesis - GO:0034330 - - - cell junction organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. - GOC:dph - GOC:jl - GOC:mah - - - - - cell junction organisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system. - apoptosis of glia - apoptosis of glial cells - glia apoptosis - glia programmed cell death by apoptosis - glial cell programmed cell death by apoptosis - programmed cell death of glia by apoptosis - programmed cell death of glial cells by apoptosis - programmed cell death, glia - programmed cell death, glial cells - glial cell apoptosis - biological_process - GO:0034349 - glial cell apoptotic process - - - - - Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system. - CL:0000125 - GOC:mtg_apoptosis - GOC:sart - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of glial cell apoptotic process. - biological_process - regulation of glial cell apoptosis - GO:0034350 - regulation of glial cell apoptotic process - - - - - Any process that modulates the frequency, rate, or extent of glial cell apoptotic process. - GOC:mah - GOC:mtg_apoptosis - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process. - down regulation of glial cell apoptosis - down-regulation of glial cell apoptosis - downregulation of glial cell apoptosis - inhibition of glial cell apoptosis - negative regulation of glial cell apoptosis - biological_process - GO:0034351 - negative regulation of glial cell apoptotic process - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process. - GOC:mah - GOC:mtg_apoptosis - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process. - up regulation of glial cell apoptosis - up-regulation of glial cell apoptosis - upregulation of glial cell apoptosis - activation of glial cell apoptosis - positive regulation of glial cell apoptosis - stimulation of glial cell apoptosis - biological_process - GO:0034352 - positive regulation of glial cell apoptotic process - - - - - Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process. - GOC:mah - GOC:mtg_apoptosis - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. - SMC apoptosis - apoptosis of smooth muscle cells - programmed cell death of smooth muscle cells by apoptosis - programmed cell death, smooth muscle cells - smooth muscle cell programmed cell death by apoptosis - smooth muscle cell apoptosis - biological_process - GO:0034390 - smooth muscle cell apoptotic process - - - - - Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. - CL:0000192 - GOC:BHF - GOC:mah - GOC:mtg_apoptosis - GOC:rl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process. - regulation of SMC apoptosis - regulation of smooth muscle cell apoptosis - biological_process - GO:0034391 - regulation of smooth muscle cell apoptotic process - - - - - Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process. - GOC:BHF - GOC:mtg_apoptosis - GOC:rl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process. - down regulation of smooth muscle cell apoptosis - down-regulation of smooth muscle cell apoptosis - downregulation of smooth muscle cell apoptosis - negative regulation of SMC apoptosis - inhibition of smooth muscle cell apoptosis - negative regulation of smooth muscle cell apoptosis - biological_process - GO:0034392 - negative regulation of smooth muscle cell apoptotic process - - - - - Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process. - GOC:BHF - GOC:mtg_apoptosis - GOC:rl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process. - positive regulation of SMC apoptosis - up regulation of smooth muscle cell apoptosis - up-regulation of smooth muscle cell apoptosis - upregulation of smooth muscle cell apoptosis - activation of smooth muscle cell apoptosis - positive regulation of smooth muscle cell apoptosis - stimulation of smooth muscle cell apoptosis - biological_process - GO:0034393 - positive regulation of smooth muscle cell apoptotic process - - - - - Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process. - GOC:BHF - GOC:mtg_apoptosis - GOC:rl - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0034436 - glycoprotein transport - - - - - The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:BHF - GOC:mah - GOC:rl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a solute is transported from one side of the vacuolar membrane to the other. - vacuolar membrane transport - biological_process - GO:0034486 - Note that this term is not intended for use in annotating lateral movement within membranes. - vacuolar transmembrane transport - - - - - The process in which a solute is transported from one side of the vacuolar membrane to the other. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which an amino acid is transported from one side of the vacuolar membrane to the other. - vacuolar amino acid membrane transport - biological_process - GO:0034487 - Note that this term is not intended for use in annotating lateral movement within membranes. - vacuolar amino acid transmembrane transport - - - - - The process in which an amino acid is transported from one side of the vacuolar membrane to the other. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. - protein localisation to chromosome - condensin localization to chromosome - biological_process - GO:0034502 - protein localization to chromosome - - - - - Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. - GOC:mah - - - - - protein localisation to chromosome - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein transports or maintains the localization of another protein to the nucleus. - 2012-11-07T15:45:54Z - GO:0044744 - protein localisation to nucleus - protein localization in cell nucleus - protein localization in nucleus - biological_process - protein targeting to nucleus - GO:0034504 - protein localization to nucleus - - - - - A process in which a protein transports or maintains the localization of another protein to the nucleus. - GOC:ecd - - - - - protein localisation to nucleus - GOC:mah - - - - - protein localization in nucleus - GOC:mah - - - - - - - - - - The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells. - cellular nitrogen compound metabolism - biological_process - GO:0034641 - - cellular nitrogen compound metabolic process - - - - - The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids. - nucleobase, nucleoside, nucleotide and nucleic acid anabolism - nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis - nucleobase, nucleoside, nucleotide and nucleic acid formation - nucleobase, nucleoside, nucleotide and nucleic acid synthesis - biological_process - GO:0034654 - nucleobase-containing compound biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids. - nucleobase, nucleoside, nucleotide and nucleic acid breakdown - nucleobase, nucleoside, nucleotide and nucleic acid catabolism - nucleobase, nucleoside, nucleotide and nucleic acid degradation - biological_process - nucleobase, nucleoside, nucleotide and nucleic acid catabolic process - GO:0034655 - - nucleobase-containing compound catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids. - GOC:mah - - - - - nucleobase, nucleoside, nucleotide and nucleic acid catabolic process - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. - regulation of membrane transport - biological_process - GO:0034762 - regulation of transmembrane transport - - - - - Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. - down regulation of transmembrane transport - down-regulation of transmembrane transport - downregulation of transmembrane transport - negative regulation of membrane transport - inhibition of transmembrane transport - biological_process - GO:0034763 - negative regulation of transmembrane transport - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. - positive regulation of membrane transport - up regulation of transmembrane transport - up-regulation of transmembrane transport - upregulation of transmembrane transport - activation of transmembrane transport - stimulation of transmembrane transport - biological_process - GO:0034764 - positive regulation of transmembrane transport - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. - regulation of ion transmembrane transport - regulation of ion membrane transport - regulation of transmembrane ion transport - biological_process - GO:0034765 - regulation of monoatomic ion transmembrane transport - - - - - Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. - GOC:mah - - - - - regulation of transmembrane ion transport - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. - negative regulation of ion transmembrane transport - down regulation of transmembrane ion transport - down-regulation of transmembrane ion transport - downregulation of transmembrane ion transport - negative regulation of ion membrane transport - negative regulation of transmembrane ion transport - inhibition of transmembrane ion transport - biological_process - GO:0034766 - negative regulation of monoatomic ion transmembrane transport - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. - GOC:mah - - - - - negative regulation of transmembrane ion transport - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. - positive regulation of ion transmembrane transport - positive regulation of ion membrane transport - positive regulation of transmembrane ion transport - up regulation of transmembrane ion transport - up-regulation of transmembrane ion transport - upregulation of transmembrane ion transport - activation of transmembrane ion transport - stimulation of transmembrane ion transport - biological_process - GO:0034767 - positive regulation of monoatomic ion transmembrane transport - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion. - dph - 2009-08-13T11:27:24Z - GO:0060881 - biological_process - basal lamina disassembly - GO:0034769 - Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer. - basement membrane disassembly - - - - - The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion. - GOC:sart - PMID:17301221 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. - biological_process - GO:0035050 - embryonic heart tube development - - - - - The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. - cardiac cell differentiation - heart cell differentiation - biological_process - GO:0035051 - cardiocyte differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. - GOC:bf - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. - GO:0035083 - GO:0035084 - ciliary axoneme assembly - cilium axoneme assembly - flagellar axoneme assembly - flagellum axoneme assembly - biological_process - axoneme biogenesis - cilium axoneme biogenesis - GO:0035082 - Note that cilia and eukaryotic flagella are deemed to be equivalent. - axoneme assembly - - - - - The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. - GOC:bf - GOC:cilia - GOC:jl - ISBN:0815316194 - - - - - axoneme biogenesis - GOC:mah - - - - - cilium axoneme biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. - biological_process - GO:0035107 - appendage morphogenesis - - - - - The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. - ISBN:0582227089 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal. - biological_process - genital morphogenesis - GO:0035112 - genitalia morphogenesis - - - - - The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal. - GOC:bf - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. - tube lumen formation - biological_process - lumen formation in an anatomical structure - GO:0035148 - tube formation - - - - - Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. - GOC:bf - - - - - tube lumen formation - GOC:dph - GOC:mah - - - - - lumen formation in an anatomical structure - GOC:dph - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex. - biological_process - GO:0035190 - syncytial nuclear migration - - - - - The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex. - GOC:bf - ISBN:0879694238 - PMID:8314839 - - - - - - - - - - - - - - - - - - - - - - - - - - - Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. - programmed cell death of ectopic germ cells - programmed cell death, ectopic germ cells - biological_process - GO:0035234 - ectopic germ cell programmed cell death - - - - - Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. - PMID:12814944 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. - biological_process - GO:0035239 - tube morphogenesis - - - - - The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. - GOC:bf - PMID:14624839 - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals. - biological_process - GO:0035260 - internal genitalia morphogenesis - - - - - The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals. - http://www.ndif.org/Terms/genitalia.html - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals. - biological_process - GO:0035261 - external genitalia morphogenesis - - - - - The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals. - http://www.ndif.org/Terms/genitalia.html - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals. - biological_process - GO:0035262 - gonad morphogenesis - - - - - The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals. - ISBN:0198612001 - - - - - - - - - - - - - - - - - - - - - - - - - - - The increase in size or mass of an entire multicellular organism, as opposed to cell growth. - biological_process - body growth - GO:0035264 - multicellular organism growth - - - - - The increase in size or mass of an entire multicellular organism, as opposed to cell growth. - GOC:bf - GOC:curators - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. - biological_process - GO:0035265 - organ growth - - - - - The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. - GOC:bf - ISBN:0471245208 - ISBN:0721662544 - - - - - - - - - - - - - - - - - - - - - - - - - - Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. - biological_process - GO:0035270 - endocrine system development - - - - - Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. - GOC:bf - Wikipedia:Development_of_the_endocrine_system - - - - - - - - - - - - - - - - - - - - - - - - - - Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. - biological_process - GO:0035272 - exocrine system development - - - - - Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. - GOC:bf - Wikipedia:Exocrine_gland - - - - - - - - - The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. - Wikipedia:Segmentation_(biology) - biological_process - GO:0035282 - segmentation - - - - - The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. - PMID:10611687 - PMID:9706689 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. - biological_process - GO:0035295 - tube development - - - - - The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. - PMID:12526790 - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained at, a microtubule. - bf - 2010-03-11T11:00:56Z - protein localisation to microtubule - biological_process - GO:0035372 - protein localization to microtubule - - - - - A process in which a protein is transported to, or maintained at, a microtubule. - GOC:bf - GOC:lb - - - - - protein localisation to microtubule - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. - bf - 2010-03-29T10:58:53Z - protein localisation to synapse - biological_process - GO:0035418 - protein localization to synapse - - - - - Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. - GOC:bf - - - - - protein localisation to synapse - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which acetate is transported across a membrane. Acetate is the 2-carbon carboxylic acid ethanoic acid. - bf - 2010-04-08T10:59:01Z - acetate membrane transport - biological_process - GO:0035433 - Note that this term is not intended for use in annotating lateral movement within membranes. - acetate transmembrane transport - - - - - The process in which acetate is transported across a membrane. Acetate is the 2-carbon carboxylic acid ethanoic acid. - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a phosphate is transported across a membrane. - bf - 2010-04-08T11:24:06Z - phosphate ion membrane transport - biological_process - GO:0035435 - Note that this term is not intended for use in annotating lateral movement within membranes. - phosphate ion transmembrane transport - - - - - The process in which a phosphate is transported across a membrane. - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes. - bf - 2010-04-09T03:53:01Z - biological_process - GO:0035441 - cell migration involved in vasculogenesis - - - - - The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes. - GOC:dgh - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. - bf - 2010-05-14T01:14:37Z - GO:0007242 - GO:0007243 - GO:0023013 - GO:0023034 - intracellular signaling chain - intracellular protein kinase cascade - intracellular signal transduction pathway - protein kinase cascade - signal transmission via intracellular cascade - biological_process - intracellular signaling cascade - intracellular signaling pathway - signal transduction via intracellular signaling cascade - GO:0035556 - - intracellular signal transduction - - - - - The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. - GOC:bf - GOC:jl - GOC:signaling - ISBN:3527303782 - - - - - intracellular signaling chain - ISBN:3527303782 - - - - - intracellular protein kinase cascade - GOC:signaling - - - - - protein kinase cascade - GOC:signaling - - - - - intracellular signaling cascade - GOC:signaling - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a protein to a specific location within the extracellular region. - bf - 2010-11-09T10:25:08Z - establishment of protein localisation in extracellular region - establishment of protein localization in extracellular region - biological_process - GO:0035592 - establishment of protein localization to extracellular region - - - - - The directed movement of a protein to a specific location within the extracellular region. - GOC:BHF - GOC:bf - - - - - establishment of protein localisation in extracellular region - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver). - bf - 2010-12-08T04:10:50Z - IHBD development - intrahepatic biliary duct development - biological_process - GO:0035622 - intrahepatic bile duct development - - - - - The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver). - GOC:bf - PMID:20614624 - - - - - IHBD development - PMID:20614624 - - - - - intrahepatic biliary duct development - PMID:20614624 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gallbladder to the common bile duct. - bf - 2010-12-10T01:24:28Z - biological_process - GO:0035628 - cystic duct development - - - - - The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gallbladder to the common bile duct. - PMID:20614624 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine. - bf - 2011-01-21T02:58:58Z - intestinal smooth muscle cell differentiation - biological_process - GO:0035645 - enteric smooth muscle cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine. - CL:0002504 - GOC:BHF - - - - - intestinal smooth muscle cell differentiation - CL:0002504 - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. - bf - 2011-03-10T02:52:36Z - sodium ion membrane transport - biological_process - GO:0035725 - Note that this term is not intended for use in annotating lateral movement within membranes. - sodium ion transmembrane transport - - - - - A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly. - bf - 2011-03-17T10:55:42Z - intraflagellar transport - Reactome:R-HSA-5620924.2 - biological_process - intraciliary transport involved in cilium morphogenesis - intraflagellar transport involved in cilium morphogenesis - GO:0035735 - intraciliary transport involved in cilium assembly - - - - - The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly. - GOC:bf - GOC:cilia - Reactome:R-HSA-5620924.2 - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis. - bf - 2011-03-17T10:57:03Z - biological_process - GO:0035736 - cell proliferation involved in compound eye morphogenesis - - - - - The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis. - GOC:bf - GOC:sart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells). - bf - 2011-04-04T11:10:38Z - angioblastic mesenchymal cell differentiation - biological_process - GO:0035779 - angioblast cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells). - CL:0000566 - GOC:yaf - - - - - angioblastic mesenchymal cell differentiation - CL:0000566 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. - bf - 2011-04-19T02:07:23Z - vitelline membrane - zona pellucida - cellular_component - GO:0035805 - egg coat - - - - - A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. - PMID:16944418 - PMID:17163408 - - - - - vitelline membrane - PMID:16944418 - PMID:17163408 - - - - - zona pellucida - PMID:16944418 - PMID:17163408 - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton. - bf - 2011-05-04T03:17:44Z - indole alkaloid metabolism - biological_process - GO:0035834 - indole alkaloid metabolic process - - - - - The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton. - GOC:yaf - - - - - indole alkaloid metabolism - GOC:bf - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton. - bf - 2011-05-04T03:18:31Z - indole alkaloid anabolism - indole alkaloid biosynthesis - indole alkaloid formation - indole alkaloid synthesis - biological_process - GO:0035835 - indole alkaloid biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton. - GOC:yaf - - - - - indole alkaloid anabolism - GOC:bf - - - - - indole alkaloid biosynthesis - GOC:bf - - - - - indole alkaloid formation - GOC:bf - - - - - indole alkaloid synthesis - GOC:bf - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates. - bf - 2011-05-06T01:54:35Z - cloacal development - biological_process - GO:0035844 - cloaca development - - - - - The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates. - GOC:dgh - ISBN:0582227089 - - - - - cloacal development - GOC:bf - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. - bf - 2011-05-13T01:28:06Z - megakaryocyte cell development - biological_process - GO:0035855 - megakaryocyte development - - - - - The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. - CL:0000556 - GOC:BHF - GOC:vk - - - - - megakaryocyte cell development - GOC:bf - - - - - - - - - - - - - - - A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm. - bf - 2011-05-25T03:09:58Z - cilial transition zone - cilium transition zone - cellular_component - connecting cilium - GO:0035869 - Depending on the species, this region may have a distinct geometrically shaped electron-dense structure within the axonemal lumen visible in electron microscopy images; most animals don't display this inner structure. The axoneme extends through the ciliary transition zone, but only consists of the outer doublets. The central pair, axonemal spokes, and dynein complexes are not found in this part of the ciliary shaft. Note that the connecting cilium of the photoreceptor cells is thought to be equivalent to the transition zone. - ciliary transition zone - - - - - A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm. - GOC:cilia - GOC:kmv - PMID:21422230 - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. - bf - 2011-06-06T11:48:51Z - biological_process - GO:0035883 - enteroendocrine cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. - CL:0000164 - GOC:bf - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. - bf - 2011-06-08T11:23:52Z - VSMC differentiation - vascular smooth muscle cell differentiation - biological_process - GO:0035886 - vascular associated smooth muscle cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. - GOC:sl - PMID:16151017 - PMID:18267954 - - - - - VSMC differentiation - PMID:16151017 - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta. - bf - 2011-06-08T11:34:26Z - biological_process - GO:0035887 - aortic smooth muscle cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta. - GOC:sl - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. - bf - 2011-06-24T11:00:07Z - biological_process - GO:0035904 - aorta development - - - - - The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. - GOC:bf - GOC:dgh - MA:0000062 - UBERON:0000947 - Wikipedia:Aorta - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. - bf - 2011-06-24T11:02:01Z - biological_process - GO:0035905 - ascending aorta development - - - - - The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. - GOC:bf - GOC:dgh - MA:0002570 - UBERON:0001496 - Wikipedia:Ascending_aorta - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. - bf - 2011-06-24T11:05:22Z - biological_process - GO:0035906 - descending aorta development - - - - - The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. - GOC:bf - GOC:dgh - MA:0002571 - UBERON:0001514 - Wikipedia:Descending_aorta - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. - bf - 2011-06-24T11:07:01Z - biological_process - GO:0035907 - dorsal aorta development - - - - - The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. - GOC:bf - GOC:dgh - UBERON:0005805 - Wikipedia:Aorta - ZFA:0000014 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. - bf - 2011-06-24T11:11:11Z - biological_process - GO:0035909 - aorta morphogenesis - - - - - The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. - GOC:bf - GOC:dgh - MA:0000062 - UBERON:0000947 - Wikipedia:Aorta - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. - bf - 2011-06-24T11:14:52Z - biological_process - GO:0035910 - ascending aorta morphogenesis - - - - - The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. - GOC:bf - GOC:dgh - MA:0002570 - UBERON:0001496 - Wikipedia:Ascending_aorta - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. - bf - 2011-06-24T11:19:24Z - biological_process - GO:0035911 - descending aorta morphogenesis - - - - - The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. - GOC:bf - GOC:dgh - MA:0002571 - UBERON:0001514 - Wikipedia:Descending_aorta - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. - bf - 2011-06-24T11:22:14Z - biological_process - GO:0035912 - dorsal aorta morphogenesis - - - - - The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. - GOC:bf - GOC:dgh - UBERON:0005805 - Wikipedia:Aorta - ZFA:0000014 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. - bf - 2011-06-24T02:36:19Z - biological_process - GO:0035914 - skeletal muscle cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. - CL:0000188 - GOC:BHF - GOC:vk - - - - - - - - - - - - - - - - - - - - - - - - - - - The regulated release of any steroid that acts as a hormone into the circulatory system. - bf - 2011-07-20T01:01:00Z - biological_process - GO:0035929 - steroid hormone secretion - - - - - The regulated release of any steroid that acts as a hormone into the circulatory system. - GOC:sl - - - - - - - - - The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates. - bf - 2011-07-20T01:11:31Z - biological_process - GO:0035935 - androgen secretion - - - - - The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates. - GOC:sl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. - bf - 2011-08-25T04:50:36Z - endoderm cell differentiation - biological_process - GO:0035987 - endodermal cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. - CL:0000223 - GOC:yaf - PMID:17624332 - - - - - endoderm cell differentiation - CL:0000223 - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force. - bf - 2011-08-26T04:14:30Z - biological_process - sinew development - GO:0035989 - tendon development - - - - - The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force. - GOC:yaf - PMID:21412429 - UBERON:0000043 - - - - - sinew development - UBERON:0000043 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts. - bf - 2011-08-30T01:35:10Z - biological_process - GO:0035992 - tendon formation - - - - - The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts. - GOC:yaf - PMID:17567668 - UBERON:0000043 - - - - - - - - - The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues. - bf - 2011-12-19T01:47:22Z - biological_process - GO:0036072 - direct ossification - - - - - The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues. - GO_REF:0000034 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population. - bf - 2012-01-17T04:06:27Z - biological_process - GO:0036093 - germ cell proliferation - - - - - The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population. - CL:0000586 - GOC:kmv - - - - - - - - - - - - - - - - - - - - - - - - - - - A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. - bf - 2012-04-20T10:20:47Z - myocyte projection - muscle arm - myopodia - cellular_component - GO:0036194 - muscle cell projection - - - - - A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. - CL:0000187 - GOC:kmv - PMID:15930100 - PMID:22464329 - - - - - myocyte projection - CL:0000187 - - - - - muscle arm - GOC:kmv - - - - - myopodia - GOC:kmv - - - - - - - - - - - - - - - - - - - - - - - - - - - The portion of the plasma membrane surrounding a muscle cell projection. - bf - 2012-04-20T10:21:51Z - cellular_component - GO:0036195 - muscle cell projection membrane - - - - - The portion of the plasma membrane surrounding a muscle cell projection. - CL:0000187 - GOC:kmv - PMID:15930100 - PMID:22464329 - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. - bf - 2012-07-20T01:05:46Z - response to lowered oxygen levels - biological_process - GO:0036293 - This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'. - response to decreased oxygen levels - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. - GOC:al - - - - - response to lowered oxygen levels - GOC:bf - - - - - - - - - - - - - - - - - - - - - - - - - - Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules. - bf - 2012-09-05T10:17:07Z - biological_process - GO:0036333 - hepatocyte homeostasis - - - - - Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules. - CL:0000182 - GOC:nhn - PMID:19878874 - - - - - - - - - - - - - - - - - - - - - - - - - - Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells. - bf - 2012-09-05T10:21:23Z - biological_process - GO:0036334 - epidermal stem cell homeostasis - - - - - Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells. - CL:1000428 - GOC:nhn - PMID:17666529 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. - bf - 2012-09-11T13:54:49Z - biological_process - GO:0036342 - post-anal tail morphogenesis - - - - - The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. - GOC:bf - GOC:kmv - Wikipedia:Chordate - - - - - - - - - - - - - - - The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. - bf - 2014-07-24T10:06:19Z - cellular_component - GO:0036477 - somatodendritic compartment - - - - - The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. - GOC:PARL - GOC:pad - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane. - bf - 2015-05-21T10:05:06Z - Golgi apparatus membrane fusion - membrane fusion involved in Golgi reassembly - post-mitotic fusion of Golgi membranes - biological_process - GO:0036504 - Golgi membrane fusion - - - - - The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane. - GOC:PARL - GOC:bf - PMID:12473691 - - - - - membrane fusion involved in Golgi reassembly - GOC:bf - - - - - post-mitotic fusion of Golgi membranes - PMID:10811609 - - - - - - - - - - - - - - - - - - - - - The increase in size or mass of an entire organism, a part of an organism or a cell. - GO:0048590 - biological_process - growth pattern - non-developmental growth - GO:0040007 - - - - - See also the biological process term 'cell growth ; GO:0016049'. - growth - - - - - The increase in size or mass of an entire organism, a part of an organism or a cell. - GOC:bf - GOC:ma - - - - - non-developmental growth - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. - biological_process - GO:0040008 - regulation of growth - - - - - Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. - GOC:ems - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Self-propelled movement of a cell or organism from one location to another. - - biological_process - GO:0040011 - - - locomotion - - - - - Self-propelled movement of a cell or organism from one location to another. - GOC:dgh - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. - biological_process - GO:0040012 - regulation of locomotion - - - - - Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. - GOC:ems - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. - down regulation of locomotion - down-regulation of locomotion - downregulation of locomotion - inhibition of locomotion - biological_process - GO:0040013 - negative regulation of locomotion - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. - regulation of body growth - regulation of body size - biological_process - GO:0040014 - regulation of multicellular organism growth - - - - - Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. - GOC:dph - GOC:ems - GOC:tb - - - - - regulation of body growth - GOC:dph - GOC:tb - - - - - regulation of body size - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. - negative regulation of body growth - negative regulation of body size - biological_process - GO:0040015 - negative regulation of multicellular organism growth - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. - GOC:dph - GOC:ems - GOC:tb - - - - - negative regulation of body growth - GOC:dph - GOC:tb - - - - - negative regulation of body size - GOC:dph - GOC:tb - - - - - - - - - - - - - - - The first few specialized divisions of an activated animal egg. - biological_process - GO:0040016 - embryonic cleavage - - - - - The first few specialized divisions of an activated animal egg. - GOC:clt - ISBN:0070524300 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. - up regulation of locomotion - up-regulation of locomotion - upregulation of locomotion - activation of locomotion - stimulation of locomotion - biological_process - GO:0040017 - positive regulation of locomotion - - - - - Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. - positive regulation of body growth - positive regulation of body size - biological_process - GO:0040018 - positive regulation of multicellular organism growth - - - - - Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. - GOC:dph - GOC:go_curators - GOC:tb - - - - - positive regulation of body growth - GOC:dph - GOC:tb - - - - - positive regulation of body size - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of embryonic development. - up regulation of embryonic development - up-regulation of embryonic development - upregulation of embryonic development - activation of embryonic development - stimulation of embryonic development - biological_process - GO:0040019 - positive regulation of embryonic development - - - - - Any process that activates or increases the frequency, rate or extent of embryonic development. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. - regulation of meiosis - biological_process - GO:0040020 - regulation of meiotic nuclear division - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. - GOC:ems - GOC:ma - - - - - regulation of meiosis - GOC:vw - - - - - - - - - Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. - heterochronic regulation of development - temporal regulation of development - biological_process - developmental timing - GO:0040034 - regulation of development, heterochronic - - - - - Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. - PMID:9442909 - - - - - - - - - - - - - - - - - - - - - - - - - - The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. - glial cell generation - biological_process - GO:0042063 - gliogenesis - - - - - The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. - GOC:dgh - GOC:jid - - - - - glial cell generation - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. - biological_process - GO:0042065 - glial cell growth - - - - - Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. - GOC:dph - GOC:isa_complete - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. - regulation of catecholamine metabolism - biological_process - GO:0042069 - regulation of catecholamine metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. - - - - - - - GO:0035734 - Wikipedia:Intraflagellar_transport - intraflagellar transport - intraflagellar transport involved in cilium organization - intraflagellar transport involved in microtubule-based flagellum organisation - biological_process - IFT - GO:0042073 - Note that we deem cilium and microtubule-based flagellum to be equivalent. - intraciliary transport - - - - - The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. - GOC:cilia - GOC:kmv - PMID:17981739 - PMID:18180368 - PMID:22869374 - Reactome:R-HSA-5620924.2 - - - - - - - - - - - - - - - - - - - - - - - - - - The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). - biological_process - GO:0042074 - cell migration involved in gastrulation - - - - - The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). - GOC:jl - ISBN:0878932437 - http://www.cellmigration.org/ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes. - GO:0048131 - germ-line stem cell renewal - biological_process - GO:0042078 - germ-line stem cell division - - - - - The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes. - GOC:jid - PMID:2279698 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cell proliferation. - - biological_process - regulation of cell proliferation - GO:0042127 - regulation of cell population proliferation - - - - - Any process that modulates the frequency, rate or extent of cell proliferation. - GOC:jl - - - - - - - - - - - - - - - The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. - nuclear membrane-ER network - nuclear membrane-endoplasmic reticulum continuum - cellular_component - NE-ER continuum - NE-ER network - nuclear envelope-ER network - nuclear envelope-endoplasmic reticulum continuum - nuclear envelope-endoplasmic reticulum network - GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network - - - - - The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. - GOC:bf - GOC:jl - GOC:mah - GOC:mcc - GOC:pr - GOC:vw - - - - - nuclear membrane-ER network - GOC:mah - - - - - nuclear membrane-endoplasmic reticulum continuum - GOC:mah - - - - - nuclear envelope-endoplasmic reticulum network - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. - https://github.com/geneontology/go-ontology/issues/23112 - kmv - 2014-08-21T15:05:45Z - GO:1903362 - GO:2000598 - regulation of cellular protein breakdown - regulation of cellular protein catabolic process - regulation of cellular protein catabolism - regulation of cellular protein degradation - regulation of protein breakdown - regulation of protein catabolism - regulation of protein degradation - regulation of cyclin breakdown - regulation of cyclin catabolic process - regulation of cyclin catabolism - regulation of cyclin degradation - regulation of degradation of cyclin - biological_process - GO:0042176 - regulation of protein catabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. - GOC:go_curators - GOC:jl - - - - - regulation of cellular protein breakdown - GOC:TermGenie - - - - - regulation of cellular protein catabolism - GOC:TermGenie - - - - - regulation of cellular protein degradation - GOC:TermGenie - - - - - regulation of cyclin breakdown - GOC:obol - - - - - regulation of cyclin catabolism - GOC:obol - - - - - regulation of cyclin degradation - GOC:obol - - - - - regulation of degradation of cyclin - GOC:obol - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process. - https://github.com/geneontology/go-ontology/issues/23112 - GO:1903363 - GO:2000599 - down regulation of cellular protein breakdown - down regulation of cellular protein catabolic process - down regulation of cellular protein catabolism - down regulation of cellular protein degradation - down regulation of protein catabolic process - down-regulation of cellular protein breakdown - down-regulation of cellular protein catabolic process - down-regulation of cellular protein catabolism - down-regulation of cellular protein degradation - down-regulation of protein catabolic process - downregulation of cellular protein breakdown - downregulation of cellular protein catabolic process - downregulation of cellular protein catabolism - downregulation of cellular protein degradation - downregulation of protein catabolic process - negative regulation of cellular protein breakdown - negative regulation of cellular protein catabolic process - negative regulation of cellular protein catabolism - negative regulation of cellular protein degradation - negative regulation of protein breakdown - negative regulation of protein catabolism - negative regulation of protein degradation - inhibition of cellular protein breakdown - inhibition of cellular protein catabolic process - inhibition of cellular protein catabolism - inhibition of cellular protein degradation - inhibition of protein catabolic process - biological_process - GO:0042177 - negative regulation of protein catabolic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process. - GOC:TermGenie - GOC:kmv - GOC:obol - GO_REF:0000058 - PMID:24785082 - - - - - down regulation of cellular protein breakdown - GOC:TermGenie - - - - - down regulation of cellular protein catabolic process - GOC:TermGenie - - - - - down regulation of cellular protein catabolism - GOC:TermGenie - - - - - down regulation of cellular protein degradation - GOC:TermGenie - - - - - down-regulation of cellular protein breakdown - GOC:TermGenie - - - - - down-regulation of cellular protein catabolic process - GOC:TermGenie - - - - - down-regulation of cellular protein catabolism - GOC:TermGenie - - - - - down-regulation of cellular protein degradation - GOC:TermGenie - - - - - downregulation of cellular protein breakdown - GOC:TermGenie - - - - - downregulation of cellular protein catabolic process - GOC:TermGenie - - - - - downregulation of cellular protein catabolism - GOC:TermGenie - - - - - downregulation of cellular protein degradation - GOC:TermGenie - - - - - negative regulation of cellular protein breakdown - GOC:TermGenie - - - - - negative regulation of cellular protein catabolism - GOC:TermGenie - - - - - negative regulation of cellular protein degradation - GOC:TermGenie - - - - - inhibition of cellular protein breakdown - GOC:TermGenie - - - - - inhibition of cellular protein catabolic process - GOC:TermGenie - - - - - inhibition of cellular protein catabolism - GOC:TermGenie - - - - - inhibition of cellular protein degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. - ketone metabolism - biological_process - GO:0042180 - - cellular ketone metabolic process - - - - - The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. - GOC:jl - ISBN:0787650153 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. - ketone anabolism - ketone biosynthesis - ketone formation - ketone synthesis - biological_process - GO:0042181 - ketone biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. - ketone breakdown - ketone catabolism - ketone degradation - biological_process - GO:0042182 - ketone catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. - response to chemical stimulus - response to chemical substance - biological_process - GO:0042221 - - - - - - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - response to chemical - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. - GOC:jl - - - - - response to chemical stimulus - GOC:dos - - - - - - - - - A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. - GO:0007046 - ribosome biogenesis and assembly - biological_process - GO:0042254 - - - - - - - - ribosome biogenesis - - - - - A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. - GOC:ma - PMID:26404467 - Wikipedia:Ribosome_biogenesis - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. - GO:0042257 - ribosomal subunit assembly - biological_process - GO:0042255 - - ribosome assembly - - - - - The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. - GOC:ma - PMID:30467428 - - - - - ribosomal subunit assembly - GOC:mah - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule. - biological_process - GO:0042325 - regulation of phosphorylation - - - - - Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. - down regulation of phosphorylation - down-regulation of phosphorylation - downregulation of phosphorylation - inhibition of phosphorylation - biological_process - GO:0042326 - negative regulation of phosphorylation - - - - - Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule. - up regulation of phosphorylation - up-regulation of phosphorylation - upregulation of phosphorylation - activation of phosphorylation - stimulation of phosphorylation - biological_process - GO:0042327 - positive regulation of phosphorylation - - - - - Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule. - GOC:jl - - - - - - - - - - - - - - - Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. - biological_process - GO:0042391 - regulation of membrane potential - - - - - Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. - GOC:jl - GOC:mtg_cardio - GOC:tb - ISBN:0198506732 - - - - - - - - - - The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. - biogenic amine anabolism - biogenic amine biosynthesis - biogenic amine formation - biogenic amine synthesis - cellular biogenic amine biosynthetic process - biological_process - GO:0042401 - biogenic amine biosynthetic process - - - - - The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. - GOC:jl - ISBN:0395825172 - - - - - - - - - The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. - biogenic amine breakdown - biogenic amine catabolism - biogenic amine degradation - biological_process - GO:0042402 - cellular biogenic amine catabolic process - - - - - The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. - GOC:go_curators - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. - levarterenol metabolic process - levarterenol metabolism - noradrenaline metabolic process - noradrenaline metabolism - norepinephrine metabolism - biological_process - GO:0042415 - norepinephrine metabolic process - - - - - The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. - levarterenol biosynthesis - levarterenol biosynthetic process - noradrenaline biosynthesis - noradrenaline biosynthetic process - norepinephrine anabolism - norepinephrine biosynthesis - norepinephrine formation - norepinephrine synthesis - biological_process - GO:0042421 - norepinephrine biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. - Wikipedia:Norepinephrine#Degradation - levarterenol catabolic process - levarterenol catabolism - noradrenaline catabolic process - noradrenaline catabolism - norepinephrine breakdown - norepinephrine catabolism - norepinephrine degradation - biological_process - GO:0042422 - norepinephrine catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. - Wikipedia:Catecholamines - catecholamine anabolism - catecholamine biosynthesis - catecholamine formation - catecholamine synthesis - biological_process - GO:0042423 - catecholamine biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. - catecholamine breakdown - catecholamine catabolism - catecholamine degradation - biological_process - GO:0042424 - catecholamine catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. - Wikipedia:Serotonin - serotonin anabolism - serotonin biosynthesis - serotonin formation - serotonin synthesis - biological_process - GO:0042427 - serotonin biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. - serotonin metabolism - biological_process - GO:0042428 - serotonin metabolic process - - - - - The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. - serotonin breakdown - serotonin catabolism - serotonin degradation - biological_process - GO:0042429 - serotonin catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. - GO:0042434 - indole and derivative metabolic process - indole and derivative metabolism - indole-containing compound metabolism - ketole metabolic process - ketole metabolism - indole derivative metabolic process - indole derivative metabolism - biological_process - GO:0042430 - indole-containing compound metabolic process - - - - - The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. - GOC:jl - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton. - indole derivative biosynthesis - indole derivative biosynthetic process - indole-containing compound anabolism - indole-containing compound biosynthesis - indole-containing compound formation - indole-containing compound synthesis - biological_process - GO:0042435 - indole-containing compound biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton. - indole derivative catabolic process - indole derivative catabolism - indole-containing compound breakdown - indole-containing compound catabolism - indole-containing compound degradation - biological_process - GO:0042436 - indole-containing compound catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. - GO:0046531 - photoreceptor morphogenesis - biological_process - GO:0042461 - photoreceptor cell development - - - - - Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. - biological_process - GO:0042462 - eye photoreceptor cell development - - - - - Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. - GOC:jl - ISBN:0192800981 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of eye photoreceptor development. - regulation of eye photoreceptor development - biological_process - GO:0042478 - regulation of eye photoreceptor cell development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of eye photoreceptor development. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of eye photoreceptor development. - positive regulation of eye photoreceptor development - up regulation of eye photoreceptor cell development - up-regulation of eye photoreceptor cell development - upregulation of eye photoreceptor cell development - activation of eye photoreceptor cell development - stimulation of eye photoreceptor cell development - biological_process - GO:0042479 - positive regulation of eye photoreceptor cell development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of eye photoreceptor development. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development. - down regulation of eye photoreceptor cell development - down-regulation of eye photoreceptor cell development - downregulation of eye photoreceptor cell development - negative regulation of eye photoreceptor development - inhibition of eye photoreceptor cell development - biological_process - GO:0042480 - negative regulation of eye photoreceptor cell development - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. - biological_process - GO:0042551 - neuron maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. - GOC:dph - GOC:jl - - - - - - - - - A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. - cellular_component - GO:0042588 - zymogen granule - - - - - A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The lipid bilayer surrounding a zymogen granule. - cellular_component - GO:0042589 - zymogen granule membrane - - - - - The lipid bilayer surrounding a zymogen granule. - GOC:jl - - - - - - - - - Any biological process involved in the maintenance of an internal steady state. - GO:0032844 - GO:0032845 - GO:0032846 - homeostasis - activation of homeostatic process - inhibition of homeostatic process - biological_process - negative regulation of homeostatic process - positive regulation of homeostatic process - regulation of homeostatic process - GO:0042592 - - - - homeostatic process - - - - - Any biological process involved in the maintenance of an internal steady state. - GOC:jl - ISBN:0395825172 - - - - - - - - - - - - - - - - - - - - - Any complex of actin, myosin, and accessory proteins. - actomyosin complex - actomyosin structure - cellular_component - GO:0042641 - actomyosin - - - - - Any complex of actin, myosin, and accessory proteins. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell. - biological_process - GO:0042670 - retinal cone cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. - biological_process - myogenesis - GO:0042692 - muscle cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. - CL:0000187 - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur. - regulation of sulfur metabolism - regulation of sulphur metabolic process - regulation of sulphur metabolism - biological_process - GO:0042762 - regulation of sulfur metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0042886 - - amide transport - - - - - The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other. - amine/amide/polyamine channel activity - molecular_function - GO:0042887 - amide transmembrane transporter activity - - - - - Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other. - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the occurrence or rate of cell death by apoptotic process. - regulation of apoptosis - biological_process - apoptosis regulator activity - GO:0042981 - This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. - regulation of apoptotic process - - - - - Any process that modulates the occurrence or rate of cell death by apoptotic process. - GOC:jl - GOC:mtg_apoptosis - - - - - - - - - - - - - - - A prolongation or process extending from a cell, e.g. a flagellum or axon. - cell process - cellular process - cellular projection - cellular_component - GO:0042995 - - - - - - cell projection - - - - - A prolongation or process extending from a cell, e.g. a flagellum or axon. - GOC:jl - http://www.cogsci.princeton.edu/~wn/ - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. - biological_process - GO:0042996 - regulation of Golgi to plasma membrane protein transport - - - - - Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. - down regulation of Golgi to plasma membrane protein transport - down-regulation of Golgi to plasma membrane protein transport - downregulation of Golgi to plasma membrane protein transport - inhibition of Golgi to plasma membrane protein transport - biological_process - GO:0042997 - negative regulation of Golgi to plasma membrane protein transport - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. - up regulation of Golgi to plasma membrane protein transport - up-regulation of Golgi to plasma membrane protein transport - upregulation of Golgi to plasma membrane protein transport - activation of Golgi to plasma membrane protein transport - stimulation of Golgi to plasma membrane protein transport - biological_process - GO:0042998 - positive regulation of Golgi to plasma membrane protein transport - - - - - Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. - biological_process - GO:0043001 - Golgi to plasma membrane protein transport - - - - - The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. - ISBN:0716731363 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. - - NIF_Subcellular:sao867568886 - neuron process - neuron protrusion - neuronal cell projection - neurite - cellular_component - nerve fiber - GO:0043005 - - neuron projection - - - - - A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. - GOC:jl - http://www.cogsci.princeton.edu/~wn/ - - - - - neuron protrusion - NIF_Subcellular:sao250931889 - - - - - nerve fiber - GOC:dph - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. - biological_process - GO:0043009 - chordate embryonic development - - - - - The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. - GOC:mtg_sensu - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. - - GO:0001747 - GO:0031075 - biological_process - GO:0043010 - camera-type eye development - - - - - The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. - GOC:go_curators - GOC:mtg_sensu - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. - NIF_Subcellular:sao1044911821 - Wikipedia:Soma_(biology) - neuron cell body - neuronal cell soma - cellular_component - GO:0043025 - - Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. - neuronal cell body - - - - - The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. - peptide anabolism - peptide biosynthesis - peptide formation - peptide synthesis - biological_process - GO:0043043 - peptide biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. - GOC:dph - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. - extracellular structure organisation - extracellular structure organization and biogenesis - biological_process - GO:0043062 - - - extracellular structure organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. - GOC:ai - GOC:dph - GOC:jl - GOC:mah - - - - - extracellular structure organization and biogenesis - GOC:dph - GOC:jl - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. - up regulation of apoptosis - up-regulation of apoptosis - upregulation of apoptosis - activation of apoptosis - positive regulation of apoptosis - stimulation of apoptosis - biological_process - pro-apoptosis - GO:0043065 - - This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. - positive regulation of apoptotic process - - - - - Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. - GOC:jl - GOC:mtg_apoptosis - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. - GO:0006916 - anti-apoptosis - down regulation of apoptosis - down-regulation of apoptosis - downregulation of apoptosis - inhibition of apoptosis - negative regulation of apoptosis - biological_process - apoptosis inhibitor activity - pro-survival - GO:0043066 - This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. - negative regulation of apoptotic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. - GOC:jl - GOC:mtg_apoptosis - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. - GO:0043070 - regulation of non-apoptotic programmed cell death - biological_process - GO:0043067 - regulation of programmed cell death - - - - - Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. - GO:0043071 - up regulation of programmed cell death - up-regulation of programmed cell death - upregulation of programmed cell death - activation of programmed cell death - positive regulation of non-apoptotic programmed cell death - stimulation of programmed cell death - biological_process - GO:0043068 - positive regulation of programmed cell death - - - - - Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. - GO:0043072 - down regulation of programmed cell death - down-regulation of programmed cell death - downregulation of programmed cell death - inhibition of programmed cell death - negative regulation of non-apoptotic programmed cell death - biological_process - GO:0043069 - negative regulation of programmed cell death - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - The nucleus of a germ cell, a reproductive cell in multicellular organisms. - germ-cell nucleus - cellular_component - GO:0043073 - germ cell nucleus - - - - - The nucleus of a germ cell, a reproductive cell in multicellular organisms. - CL:0000586 - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the activity of an enzyme. - GO:0048554 - positive regulation of enzyme activity - up regulation of enzyme activity - up-regulation of enzyme activity - upregulation of enzyme activity - activation of enzyme activity - activation of metalloenzyme activity - positive regulation of metalloenzyme activity - stimulation of enzyme activity - stimulation of metalloenzyme activity - up regulation of metalloenzyme activity - up-regulation of metalloenzyme activity - upregulation of metalloenzyme activity - biological_process - GO:0043085 - - - positive regulation of catalytic activity - - - - - Any process that activates or increases the activity of an enzyme. - GOC:ebc - GOC:jl - GOC:tb - GOC:vw - - - - - positive regulation of enzyme activity - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops or reduces the activity of an enzyme. - GO:0048553 - down regulation of enzyme activity - down-regulation of enzyme activity - down-regulation of metalloenzyme activity - downregulation of enzyme activity - negative regulation of enzyme activity - down regulation of metalloenzyme activity - downregulation of metalloenzyme activity - inhibition of enzyme activity - inhibition of metalloenzyme activity - negative regulation of metalloenzyme activity - biological_process - GO:0043086 - - negative regulation of catalytic activity - - - - - Any process that stops or reduces the activity of an enzyme. - GOC:ebc - GOC:jl - GOC:tb - GOC:vw - - - - - negative regulation of enzyme activity - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine. - biological_process - GO:0043133 - hindgut contraction - - - - - A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine. - GOC:jl - GOC:mtg_muscle - UBERON:0001046 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. - biological_process - GO:0043134 - regulation of hindgut contraction - - - - - Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. - GOC:jl - UBERON:0001046 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location. - establishment and maintenance of translational machinery localization - establishment and maintenance of translational protein localization - regulation of translation by machinery localisation - translational machinery localization - translational protein localization - biological_process - GO:0043143 - regulation of translation by machinery localization - - - - - Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location. - GOC:jl - - - - - regulation of translation by machinery localisation - GOC:mah - - - - - translational machinery localization - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GO:0034960 - GO:0043283 - GO:0044259 - biopolymer metabolic process - macromolecule metabolism - organismal macromolecule metabolism - multicellular organismal macromolecule metabolic process - biological_process - GO:0043170 - - macromolecule metabolic process - - - - - The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:mah - - - - - biopolymer metabolic process - GOC:mtg_chebi_dec09 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. - peptide breakdown - peptide catabolism - peptide degradation - biological_process - GO:0043171 - peptide catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. - GO:0010237 - response to amino acid stimulus - biological_process - GO:0043200 - response to amino acid - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. - GOC:ef - GOC:mlg - - - - - response to amino acid stimulus - GOC:dos - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things. - biological_process - GO:0043207 - response to external biotic stimulus - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things. - GOC:go_curators - - - - - - - - - Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. - NIF_Subcellular:sao1539965131 - Wikipedia:Organelle - cellular_component - GO:0043226 - - - - - organelle - - - - - Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. - NIF_Subcellular:sao414196390 - membrane-enclosed organelle - cellular_component - GO:0043227 - membrane-bounded organelle - - - - - Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. - GOC:go_curators - - - - - - - - - Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. - https://github.com/geneontology/go-ontology/issues/21881 - NIF_Subcellular:sao1456184038 - non-membrane-enclosed organelle - cellular_component - biological condensate - GO:0043228 - - non-membrane-bounded organelle - - - - - Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. - cellular_component - GO:0043229 - - intracellular organelle - - - - - Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi. - cellular_component - GO:0043230 - - extracellular organelle - - - - - Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi. - GOC:jl - PMID:9914479 - - - - - - - - - - - - - - - - - - - - - - - - - - - Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. - intracellular membrane-enclosed organelle - cellular_component - GO:0043231 - - intracellular membrane-bounded organelle - - - - - Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. - intracellular non-membrane-enclosed organelle - cellular_component - GO:0043232 - - intracellular non-membrane-bounded organelle - - - - - Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen. - cellular_component - GO:0043233 - - organelle lumen - - - - - The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen. - GOC:jl - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. - down regulation of protein complex disassembly - down-regulation of protein complex disassembly - downregulation of protein complex disassembly - inhibition of protein complex disassembly - biological_process - negative regulation of protein complex disassembly - GO:0043242 - negative regulation of protein-containing complex disassembly - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. - up regulation of protein complex disassembly - up-regulation of protein complex disassembly - upregulation of protein complex disassembly - activation of protein complex disassembly - stimulation of protein complex disassembly - biological_process - positive regulation of protein complex disassembly - GO:0043243 - positive regulation of protein-containing complex disassembly - - - - - Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. - biological_process - regulation of protein complex disassembly - GO:0043244 - regulation of protein-containing complex disassembly - - - - - Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. - RBC maturation - red blood cell maturation - biological_process - GO:0043249 - erythrocyte maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. - GOC:devbiol - GOC:jl - - - - - RBC maturation - CL:0000232 - - - - - red blood cell maturation - CL:0000232 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of protein complex assembly. - biological_process - regulation of protein complex assembly - GO:0043254 - regulation of protein-containing complex assembly - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of protein complex assembly. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. - regulation of carbohydrate anabolism - regulation of carbohydrate biosynthesis - regulation of carbohydrate formation - regulation of carbohydrate synthesis - biological_process - GO:0043255 - regulation of carbohydrate biosynthetic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. - extracellular non-membrane-enclosed organelle - cellular_component - GO:0043264 - extracellular non-membrane-bounded organelle - - - - - Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - regulation of ion transport - biological_process - GO:0043269 - regulation of monoatomic ion transport - - - - - Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - up regulation of ion transport - up-regulation of ion transport - upregulation of ion transport - activation of ion transport - stimulation of ion transport - biological_process - GO:0043270 - positive regulation of monoatomic ion transport - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - negative regulation of ion transport - down regulation of ion transport - down-regulation of ion transport - downregulation of ion transport - inhibition of ion transport - biological_process - GO:0043271 - negative regulation of monoatomic ion transport - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. - biological_process - GO:0043279 - response to alkaloid - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. - contractile fibre - cellular_component - GO:0043292 - contractile fiber - - - - - Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. - GOC:go_curators - ISBN:0815316194 - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus. - enucleate RBC differentiation - enucleate red blood cell differentiation - biological_process - GO:0043353 - enucleate erythrocyte differentiation - - - - - The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus. - GOC:go_curators - - - - - enucleate RBC differentiation - CL:0000232 - - - - - enucleate red blood cell differentiation - CL:0000232 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus. - enucleate RBC maturation - enucleate red blood cell maturation - biological_process - GO:0043354 - enucleate erythrocyte maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus. - GOC:go_curators - - - - - enucleate RBC maturation - CL:0000232 - - - - - enucleate red blood cell maturation - CL:0000232 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus. - nucleate RBC maturation - nucleate red blood cell maturation - biological_process - GO:0043362 - nucleate erythrocyte maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus. - GOC:devbiol - GOC:jl - - - - - nucleate RBC maturation - CL:0000232 - - - - - nucleate red blood cell maturation - CL:0000232 - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds. - nucleate RBC differentiation - nucleate red blood cell differentiation - biological_process - GO:0043363 - nucleate erythrocyte differentiation - - - - - The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds. - GOC:jl - - - - - nucleate RBC differentiation - CL:0000232 - - - - - nucleate red blood cell differentiation - CL:0000232 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. - response to peptide hormone stimulus - response to polypeptide hormone stimulus - biological_process - GO:0043434 - response to peptide hormone - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. - PMID:11027914 - PMID:15134857 - Wikipedia:Peptide_hormone - - - - - response to peptide hormone stimulus - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). - keto acid metabolic process - keto acid metabolism - ketoacid metabolic process - ketoacid metabolism - oxo acid metabolic process - oxo acid metabolism - oxoacid metabolism - biological_process - GO:0043436 - oxoacid metabolic process - - - - - The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). - Wikipedia:Oxyacid - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. - regulation of secondary metabolism - biological_process - GO:0043455 - regulation of secondary metabolic process - - - - - Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. - biological_process - GO:0043467 - regulation of generation of precursor metabolites and energy - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. - biological_process - GO:0043470 - regulation of carbohydrate catabolic process - - - - - Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. - GOC:mlg - - - - - - - - - - - - - - - - - - - - - The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. - biological_process - GO:0043473 - - - pigmentation - - - - - The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. - GOC:jl - - - - - - - - - - - - - - - - A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. - biological_process - muscle plasticity - GO:0043500 - - muscle adaptation - - - - - A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. - GOC:mtg_muscle - PMID:11181628 - PMID:11449884 - PMID:12605307 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. - biological_process - skeletal muscle plasticity - GO:0043501 - skeletal muscle adaptation - - - - - Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. - GOC:mtg_muscle - PMID:11181628 - PMID:11449884 - PMID:12605307 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of muscle adaptation. - biological_process - regulation of muscle plasticity - GO:0043502 - regulation of muscle adaptation - - - - - Any process that modulates the frequency, rate or extent of muscle adaptation. - GOC:go_curators - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. - regulation of apoptosis of neuronal cells - regulation of apoptosis of neurons - regulation of neuron programmed cell death - regulation of neuronal cell programmed cell death - regulation of programmed cell death of neuronal cells - regulation of programmed cell death, neurons - regulation of neuron apoptosis - biological_process - GO:0043523 - regulation of neuron apoptotic process - - - - - Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. - GOC:go_curators - GOC:mtg_apoptosis - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. - down regulation of neuron apoptosis - down-regulation of neuron apoptosis - downregulation of neuron apoptosis - negative regulation of programmed cell death, neurons - inhibition of neuron apoptosis - negative regulation of neuron apoptosis - neuron survival - biological_process - GO:0043524 - negative regulation of neuron apoptotic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. - GOC:go_curators - GOC:mtg_apoptosis - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. - positive regulation of programmed cell death, neurons - up regulation of neuron apoptosis - up-regulation of neuron apoptosis - upregulation of neuron apoptosis - activation of neuron apoptosis - positive regulation of neuron apoptosis - stimulation of neuron apoptosis - biological_process - GO:0043525 - positive regulation of neuron apoptotic process - - - - - Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. - GOC:go_curators - GOC:mtg_apoptosis - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. - biological_process - GO:0043549 - - regulation of kinase activity - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. - GOC:bf - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. - biological_process - GO:0043576 - regulation of respiratory gaseous exchange - - - - - Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. - - - animal skin development - biological_process - GO:0043588 - skin development - - - - - The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. - GOC:jl - UBERON:0002097 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. - biological_process - GO:0043589 - skin morphogenesis - - - - - The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. - GOC:jl - UBERON:0002097 - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. - amide metabolism - cellular amide metabolic process - biological_process - GO:0043603 - - amide metabolic process - - - - - The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. - GOC:curators - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. - biological_process - GO:0043604 - amide biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. - GOC:curators - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. - cellular amide catabolic process - biological_process - GO:0043605 - amide catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. - GOC:curators - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). - dicarboxylate metabolic process - dicarboxylate metabolism - dicarboxylic acid metabolism - biological_process - GO:0043648 - dicarboxylic acid metabolic process - - - - - The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. - dicarboxylate catabolic process - dicarboxylate catabolism - dicarboxylic acid breakdown - dicarboxylic acid catabolism - dicarboxylic acid degradation - biological_process - GO:0043649 - dicarboxylic acid catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. - dicarboxylate biosynthesis - dicarboxylate biosynthetic process - dicarboxylic acid anabolism - dicarboxylic acid biosynthesis - dicarboxylic acid formation - dicarboxylic acid synthesis - biological_process - GO:0043650 - dicarboxylic acid biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state. - ossification involved in skeletal development - ossification involved in bone modeling - biological_process - GO:0043931 - ossification involved in bone maturation - - - - - The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state. - GOC:dph - GOC:mah - GOC:mtg_mpo - - - - - ossification involved in skeletal development - GOC:dph - - - - - ossification involved in bone modeling - GO_REF:0000034 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. - https://github.com/geneontology/go-ontology/issues/22580 - mah - 2010-09-08T10:01:42Z - GO:0034600 - GO:0034621 - GO:0071822 - protein complex subunit organisation - protein complex subunit organization - biological_process - cellular macromolecular complex organization - cellular macromolecular complex subunit organisation - cellular macromolecular complex subunit organization - macromolecular complex organization - macromolecular complex subunit organisation - macromolecular complex subunit organization - protein-containing complex subunit organization - GO:0043933 - protein-containing complex organization - - - - - Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. - GOC:mah - - - - - protein complex subunit organisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. - glucan metabolism - biological_process - GO:0044042 - glucan metabolic process - - - - - The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. - biological_process - GO:0044057 - regulation of system process - - - - - Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. - biological_process - GO:0044058 - regulation of digestive system process - - - - - Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. - regulation of endocrine system process - biological_process - GO:0044060 - regulation of endocrine process - - - - - Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. - biological_process - GO:0044062 - regulation of excretion - - - - - Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. - biological_process - GO:0044065 - regulation of respiratory system process - - - - - Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. - GOC:jl - - - - - - - - - A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. - GO:0071843 - cellular component biogenesis at cellular level - biological_process - GO:0044085 - - cellular component biogenesis - - - - - A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. - GOC:jl - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. - biological_process - GO:0044087 - regulation of cellular component biogenesis - - - - - Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. - regulation of vacuole organisation - biological_process - regulation of vacuole biogenesis - GO:0044088 - regulation of vacuole organization - - - - - Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. - GOC:jl - GOC:mah - - - - - regulation of vacuole organisation - GOC:mah - - - - - regulation of vacuole biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. - biological_process - GO:0044089 - positive regulation of cellular component biogenesis - - - - - Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. - positive regulation of vacuole organisation - biological_process - positive regulation of vacuole biogenesis - GO:0044090 - positive regulation of vacuole organization - - - - - Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. - GOC:jl - GOC:mah - - - - - positive regulation of vacuole organisation - GOC:mah - - - - - positive regulation of vacuole biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. - biological_process - GO:0044091 - membrane biogenesis - - - - - A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. - jl - 2009-04-21T04:07:27Z - biological_process - GO:0044092 - - negative regulation of molecular function - - - - - Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. - GO:jl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. - jl - 2009-04-21T04:11:06Z - biological_process - GO:0044093 - - positive regulation of molecular function - - - - - Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. - GO:jl - - - - - - - - - - - - - - - A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). - jl - 2009-10-22T02:38:55Z - translation initiation (ternary) complex - Met-tRNA/eIF2.GTP ternary complex - cellular_component - GO:0044207 - translation initiation ternary complex - - - - - A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). - GOC:jl - - - - - - - - - - The chemical reactions and pathways by which individual cells transform chemical substances. - cellular metabolism - biological_process - intermediary metabolism - GO:0044237 - - This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. - cellular metabolic process - - - - - The chemical reactions and pathways by which individual cells transform chemical substances. - GOC:go_curators - - - - - intermediary metabolism - GOC:mah - - - - - - - - - The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. - primary metabolism - biological_process - GO:0044238 - - primary metabolic process - - - - - The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. - GOC:go_curators - http://www.metacyc.org - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. - cellular breakdown - cellular catabolism - cellular degradation - biological_process - GO:0044248 - cellular catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. - GOC:jl - - - - - - - - - - The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. - cellular anabolism - cellular biosynthesis - cellular formation - cellular synthesis - biological_process - GO:0044249 - cellular biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas. - intestinal lipid breakdown - intestinal lipid catabolism - intestinal lipid degradation - biological_process - GO:0044258 - intestinal lipid catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas. - GOC:jl - http://www.emc.maricopa.edu/ - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds. - nitrogen compound breakdown - nitrogen compound catabolism - nitrogen compound degradation - biological_process - GO:0044270 - cellular nitrogen compound catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds. - GOC:jl - ISBN:0198506732 - - - - - - - - - - The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds. - nitrogen compound anabolism - nitrogen compound biosynthesis - nitrogen compound formation - nitrogen compound synthesis - biological_process - GO:0044271 - cellular nitrogen compound biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds. - GOC:jl - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. - sulfur compound anabolism - sulfur compound biosynthesis - sulfur compound formation - sulfur compound synthesis - sulfur biosynthesis - sulfur biosynthetic process - biological_process - GO:0044272 - sulfur compound biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. - sulfur compound breakdown - sulfur compound catabolism - sulfur compound degradation - sulfur catabolic process - sulfur catabolism - biological_process - GO:0044273 - sulfur compound catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. - GOC:jl - - - - - - - - - The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. - jl - 2010-01-26T12:05:20Z - small molecule metabolism - biological_process - GO:0044281 - - - - Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. - small molecule metabolic process - - - - - The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. - GOC:curators - GOC:pde - GOC:vw - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. - jl - 2010-01-26T12:06:10Z - small molecule catabolism - biological_process - GO:0044282 - Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. - small molecule catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. - GOC:curators - GOC:vw - - - - - - - - - - The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. - jl - 2010-01-26T12:06:49Z - small molecule biosynthesis - biological_process - GO:0044283 - - Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. - small molecule biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. - GOC:curators - GOC:pde - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. - - jl - 2010-02-05T10:37:16Z - FBbt:00005107 - FMA:67301 - Wikipedia:Cell_body - cell soma - cellular_component - GO:0044297 - Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. - cell body - - - - - The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin. - jl - 2010-08-25T01:44:51Z - pancreatic B cell proliferation - pancreatic beta cell proliferation - biological_process - GO:0044342 - type B pancreatic cell proliferation - - - - - The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin. - GOC:jl - GOC:yaf - - - - - pancreatic B cell proliferation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. - jl - 2010-09-23T11:33:38Z - fibroblast apoptosis - biological_process - GO:0044346 - fibroblast apoptotic process - - - - - Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. - CL:0000057 - GOC:jl - GOC:mtg_apoptosis - GOC:yaf - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. - jl - 2011-12-13T11:43:24Z - protein localisation to cytoskeleton - biological_process - GO:0044380 - protein localization to cytoskeleton - - - - - A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. - GOC:jl - - - - - protein localisation to cytoskeleton - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process evolved to enable an interaction with an organism of a different species. - https://github.com/geneontology/go-ontology/issues/20191 - - interaction with another species - interspecies interaction - interspecies interaction between organisms - interspecies interaction with other organisms - biological_process - GO:0044419 - - - - biological process involved in interspecies interaction between organisms - - - - - Any process evolved to enable an interaction with an organism of a different species. - GOC:cc - - - - - - - - - - The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. - jl - 2012-03-29T01:55:18Z - secondary metabolite biosynthesis - biological_process - GO:0044550 - - secondary metabolite biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. - jl - 2013-03-27T15:09:58Z - microtubule-based flagellum organization - biological_process - GO:0044782 - - - Note that we deem cilium and microtubule-based flagellum to be equivalent. - cilium organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. - GOC:cilia - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell. - GO:0006947 - cell fusion - cell-cell fusion - biological_process - GO:0045026 - plasma membrane fusion - - - - - The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell. - GOC:elh - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. - biological_process - GO:0045132 - meiotic chromosome segregation - - - - - The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. - GOC:ai - GOC:mah - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. - biological_process - GO:0045137 - development of primary sexual characteristics - - - - - The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. - GOC:ai - - - - - - - - - - - - - - - The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate. - https://github.com/geneontology/go-ontology/issues/24390 - biological_process - GO:0045165 - Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created. - cell fate commitment - - - - - The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate. - ISBN:0716731185 - - - - - - - - - - - - - - - - - - - - - - - - - - Signaling at long or short range between cells that results in the commitment of a cell to a certain fate. - cell fate commitment, cell-cell signaling - cell fate commitment, cell-cell signalling - cell-cell signaling during in cell fate commitment - cell-cell signaling resulting in cell fate commitment - cell-cell signalling during cell fate commitment - cell-cell signalling resulting in cell fate commitment - cell-cell signalling involved in cell fate specification - biological_process - GO:0045168 - cell-cell signaling involved in cell fate commitment - - - - - Signaling at long or short range between cells that results in the commitment of a cell to a certain fate. - GOC:dph - GOC:go_curators - GOC:tb - - - - - cell-cell signalling involved in cell fate specification - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a protein to a specific location. - establishment of protein localisation - protein positioning - protein recruitment - biological_process - GO:0045184 - establishment of protein localization - - - - - The directed movement of a protein to a specific location. - GOC:bf - - - - - establishment of protein localisation - GOC:mah - - - - - - - - - - - - - - - Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. - GO:0043339 - GO:0043342 - establishment and/or maintenance of neuroblast cell polarity - biological_process - GO:0045196 - establishment or maintenance of neuroblast polarity - - - - - Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. - GOC:bf - GOC:mah - GOC:mtg_sensu - PMID:19375318 - PMID:20066083 - - - - - - - - - - - - - - - - - - - - - - - - - - - The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. - GO:0043340 - GO:0043343 - establishment of neuroblast cell polarity - biological_process - GO:0045200 - establishment of neuroblast polarity - - - - - The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. - GOC:bf - GOC:mtg_sensu - - - - - - - - - - - - - - - - - - - - - The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. - NIF_Subcellular:sao914572699 - Wikipedia:Chemical_synapse - synaptic junction - mixed synapse - cellular_component - electrotonic synapse - GO:0045202 - - - - - - - synapse - - - - - The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. - GOC:aruk - ISBN:0198506732 - PMID:24619342 - PMID:29383328 - PMID:31998110 - - - - - mixed synapse - NIF_Subcellular:sao1506103497 - - - - - electrotonic synapse - NIF_Subcellular:sao1311109124 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. - GO:0006938 - sarcomere alignment - sarcomere organisation - biological_process - GO:0045214 - sarcomere organization - - - - - The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. - GOC:bf - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells. - cell-cell junction assembly and maintenance - cell-cell junction organisation - intercellular junction assembly and maintenance - biological_process - cell-cell junction biogenesis - GO:0045216 - cell-cell junction organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells. - GOC:ai - GOC:dph - GOC:jl - GOC:mah - - - - - cell-cell junction organisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions. - CD4 anabolism - CD4 biosynthesis - CD4 formation - CD4 synthesis - biological_process - GO:0045222 - CD4 biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions. - GOC:go_curators - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. - regulation of CD4 anabolism - regulation of CD4 biosynthesis - regulation of CD4 biosynthetic process - regulation of CD4 formation - regulation of CD4 synthesis - biological_process - GO:0045223 - regulation of CD4 production - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. - positive regulation of CD4 anabolism - positive regulation of CD4 biosynthesis - positive regulation of CD4 biosynthetic process - positive regulation of CD4 formation - positive regulation of CD4 synthesis - up regulation of CD4 biosynthetic process - up-regulation of CD4 biosynthetic process - upregulation of CD4 biosynthetic process - activation of CD4 biosynthetic process - stimulation of CD4 biosynthetic process - biological_process - GO:0045224 - positive regulation of CD4 production - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. - down regulation of CD4 biosynthetic process - down-regulation of CD4 biosynthetic process - downregulation of CD4 biosynthetic process - negative regulation of CD4 anabolism - negative regulation of CD4 biosynthesis - negative regulation of CD4 biosynthetic process - negative regulation of CD4 formation - negative regulation of CD4 synthesis - inhibition of CD4 biosynthetic process - biological_process - GO:0045225 - negative regulation of CD4 production - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell. - external encapsulating structure organisation - external encapsulating structure organization and biogenesis - biological_process - GO:0045229 - - external encapsulating structure organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell. - GOC:ai - GOC:dph - GOC:jl - GOC:mah - - - - - external encapsulating structure organization and biogenesis - GOC:dph - GOC:jl - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. - adipocyte cell differentiation - adipocyte differentiation - adipose cell differentiation - biological_process - adipogenesis - GO:0045444 - fat cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. - CL:0000136 - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. - myoblast cell differentiation - biological_process - GO:0045445 - myoblast differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. - CL:0000056 - GOC:go_curators - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. - biological_process - GO:0045446 - endothelial cell differentiation - - - - - The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. - CL:0000115 - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. - biological_process - GO:0045595 - regulation of cell differentiation - - - - - Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. - down regulation of cell differentiation - down-regulation of cell differentiation - downregulation of cell differentiation - inhibition of cell differentiation - biological_process - GO:0045596 - negative regulation of cell differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cell differentiation. - up regulation of cell differentiation - up-regulation of cell differentiation - upregulation of cell differentiation - activation of cell differentiation - stimulation of cell differentiation - biological_process - GO:0045597 - positive regulation of cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of cell differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of adipocyte differentiation. - regulation of adipocyte cell differentiation - regulation of adipocyte differentiation - biological_process - GO:0045598 - regulation of fat cell differentiation - - - - - Any process that modulates the frequency, rate or extent of adipocyte differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. - down regulation of fat cell differentiation - down-regulation of fat cell differentiation - downregulation of fat cell differentiation - negative regulation of adipocyte cell differentiation - negative regulation of adipocyte differentiation - inhibition of fat cell differentiation - biological_process - GO:0045599 - negative regulation of fat cell differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. - positive regulation of adipocyte cell differentiation - positive regulation of adipocyte differentiation - up regulation of fat cell differentiation - up-regulation of fat cell differentiation - upregulation of fat cell differentiation - activation of fat cell differentiation - stimulation of fat cell differentiation - biological_process - GO:0045600 - positive regulation of fat cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of endothelial cell differentiation. - biological_process - GO:0045601 - regulation of endothelial cell differentiation - - - - - Any process that modulates the frequency, rate or extent of endothelial cell differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation. - down regulation of endothelial cell differentiation - down-regulation of endothelial cell differentiation - downregulation of endothelial cell differentiation - inhibition of endothelial cell differentiation - biological_process - GO:0045602 - negative regulation of endothelial cell differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. - up regulation of endothelial cell differentiation - up-regulation of endothelial cell differentiation - upregulation of endothelial cell differentiation - activation of endothelial cell differentiation - stimulation of endothelial cell differentiation - biological_process - GO:0045603 - positive regulation of endothelial cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of epidermal cell differentiation. - biological_process - regulation of hypodermal cell differentiation - GO:0045604 - regulation of epidermal cell differentiation - - - - - Any process that modulates the frequency, rate or extent of epidermal cell differentiation. - GOC:go_curators - - - - - regulation of hypodermal cell differentiation - GOC:kmv - GOC:rk - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. - down regulation of epidermal cell differentiation - down-regulation of epidermal cell differentiation - downregulation of epidermal cell differentiation - inhibition of epidermal cell differentiation - biological_process - negative regulation of hypodermal cell differentiation - GO:0045605 - negative regulation of epidermal cell differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. - GOC:go_curators - - - - - negative regulation of hypodermal cell differentiation - GOC:kmv - GOC:rk - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. - up regulation of epidermal cell differentiation - up-regulation of epidermal cell differentiation - upregulation of epidermal cell differentiation - activation of epidermal cell differentiation - stimulation of epidermal cell differentiation - biological_process - positive regulation of hypodermal cell differentiation - GO:0045606 - positive regulation of epidermal cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. - GOC:go_curators - - - - - positive regulation of hypodermal cell differentiation - GOC:kmv - GOC:rk - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of myeloid cell differentiation. - biological_process - GO:0045637 - regulation of myeloid cell differentiation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of myeloid cell differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. - down regulation of myeloid cell differentiation - down-regulation of myeloid cell differentiation - downregulation of myeloid cell differentiation - inhibition of myeloid cell differentiation - biological_process - GO:0045638 - negative regulation of myeloid cell differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. - up regulation of myeloid cell differentiation - up-regulation of myeloid cell differentiation - upregulation of myeloid cell differentiation - activation of myeloid cell differentiation - stimulation of myeloid cell differentiation - biological_process - GO:0045639 - positive regulation of myeloid cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of erythrocyte differentiation. - regulation of RBC differentiation - regulation of red blood cell differentiation - biological_process - GO:0045646 - regulation of erythrocyte differentiation - - - - - Any process that modulates the frequency, rate or extent of erythrocyte differentiation. - GOC:go_curators - - - - - regulation of RBC differentiation - CL:0000232 - - - - - regulation of red blood cell differentiation - CL:0000232 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation. - down regulation of erythrocyte differentiation - down-regulation of erythrocyte differentiation - downregulation of erythrocyte differentiation - negative regulation of RBC differentiation - negative regulation of red blood cell differentiation - inhibition of erythrocyte differentiation - biological_process - GO:0045647 - negative regulation of erythrocyte differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation. - GOC:go_curators - - - - - negative regulation of RBC differentiation - CL:0000232 - - - - - negative regulation of red blood cell differentiation - CL:0000232 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. - positive regulation of RBC differentiation - positive regulation of red blood cell differentiation - up regulation of erythrocyte differentiation - up-regulation of erythrocyte differentiation - upregulation of erythrocyte differentiation - activation of erythrocyte differentiation - stimulation of erythrocyte differentiation - biological_process - GO:0045648 - positive regulation of erythrocyte differentiation - - - - - Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. - GOC:go_curators - - - - - positive regulation of RBC differentiation - CL:0000232 - - - - - positive regulation of red blood cell differentiation - CL:0000232 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. - biological_process - GO:0045652 - regulation of megakaryocyte differentiation - - - - - Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. - down regulation of megakaryocyte differentiation - down-regulation of megakaryocyte differentiation - downregulation of megakaryocyte differentiation - inhibition of megakaryocyte differentiation - biological_process - GO:0045653 - negative regulation of megakaryocyte differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation. - up regulation of megakaryocyte differentiation - up-regulation of megakaryocyte differentiation - upregulation of megakaryocyte differentiation - activation of megakaryocyte differentiation - stimulation of megakaryocyte differentiation - biological_process - GO:0045654 - positive regulation of megakaryocyte differentiation - - - - - Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. - biological_process - GO:0045661 - regulation of myoblast differentiation - - - - - Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. - CL:0000056 - GOC:go_curators - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. - down regulation of myoblast differentiation - down-regulation of myoblast differentiation - downregulation of myoblast differentiation - inhibition of myoblast differentiation - biological_process - GO:0045662 - negative regulation of myoblast differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. - CL:0000056 - GOC:go_curators - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. - up regulation of myoblast differentiation - up-regulation of myoblast differentiation - upregulation of myoblast differentiation - activation of myoblast differentiation - stimulation of myoblast differentiation - biological_process - GO:0045663 - positive regulation of myoblast differentiation - - - - - Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. - CL:0000056 - GOC:go_curators - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of neuron differentiation. - biological_process - GO:0045664 - regulation of neuron differentiation - - - - - Any process that modulates the frequency, rate or extent of neuron differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. - down regulation of neuron differentiation - down-regulation of neuron differentiation - downregulation of neuron differentiation - inhibition of neuron differentiation - biological_process - GO:0045665 - negative regulation of neuron differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of neuron differentiation. - up regulation of neuron differentiation - up-regulation of neuron differentiation - upregulation of neuron differentiation - activation of neuron differentiation - stimulation of neuron differentiation - biological_process - GO:0045666 - positive regulation of neuron differentiation - - - - - Any process that activates or increases the frequency, rate or extent of neuron differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of epidermis development. - regulation of epidermal development - biological_process - regulation of hypodermis development - GO:0045682 - regulation of epidermis development - - - - - Any process that modulates the frequency, rate or extent of epidermis development. - GOC:go_curators - - - - - regulation of hypodermis development - GOC:kmv - GOC:rk - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. - down regulation of epidermis development - down-regulation of epidermis development - downregulation of epidermis development - negative regulation of epidermal development - inhibition of epidermis development - biological_process - negative regulation of hypodermis development - GO:0045683 - negative regulation of epidermis development - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. - GOC:go_curators - - - - - negative regulation of hypodermis development - GOC:kmv - GOC:rk - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of epidermis development. - positive regulation of epidermal development - up regulation of epidermis development - up-regulation of epidermis development - upregulation of epidermis development - activation of epidermis development - stimulation of epidermis development - biological_process - positive regulation of hypodermis development - GO:0045684 - positive regulation of epidermis development - - - - - Any process that activates or increases the frequency, rate or extent of epidermis development. - GOC:go_curators - - - - - positive regulation of hypodermis development - GOC:kmv - GOC:rk - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of glia cell differentiation. - regulation of glia cell differentiation - regulation of neuroglia differentiation - biological_process - GO:0045685 - regulation of glial cell differentiation - - - - - Any process that modulates the frequency, rate or extent of glia cell differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. - down regulation of glial cell differentiation - down-regulation of glial cell differentiation - downregulation of glial cell differentiation - negative regulation of glia cell differentiation - negative regulation of neuroglia differentiation - inhibition of glial cell differentiation - biological_process - GO:0045686 - negative regulation of glial cell differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of glia cell differentiation. - positive regulation of glia cell differentiation - positive regulation of neuroglia differentiation - up regulation of glial cell differentiation - up-regulation of glial cell differentiation - upregulation of glial cell differentiation - activation of glial cell differentiation - stimulation of glial cell differentiation - biological_process - GO:0045687 - positive regulation of glial cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of glia cell differentiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. - down regulation of glycogen biosynthetic process - down-regulation of glycogen biosynthetic process - downregulation of glycogen biosynthetic process - negative regulation of glycogen anabolism - negative regulation of glycogen biosynthesis - negative regulation of glycogen formation - negative regulation of glycogen synthesis - inhibition of glycogen biosynthetic process - biological_process - GO:0045719 - negative regulation of glycogen biosynthetic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. - down regulation of gluconeogenesis - down-regulation of gluconeogenesis - downregulation of gluconeogenesis - inhibition of gluconeogenesis - biological_process - GO:0045721 - negative regulation of gluconeogenesis - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of gluconeogenesis. - up regulation of gluconeogenesis - up-regulation of gluconeogenesis - upregulation of gluconeogenesis - activation of gluconeogenesis - stimulation of gluconeogenesis - biological_process - GO:0045722 - positive regulation of gluconeogenesis - - - - - Any process that activates or increases the frequency, rate or extent of gluconeogenesis. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the formation of a cilium. - positive regulation of flagellum assembly - up regulation of cilium assembly - up-regulation of cilium assembly - upregulation of cilium assembly - activation of cilium assembly - stimulation of cilium assembly - biological_process - positive regulation of flagellum biogenesis - GO:0045724 - positive regulation of cilium assembly - - - - - Any process that activates or increases the frequency, rate or extent of the formation of a cilium. - GOC:cilia - GOC:go_curators - - - - - positive regulation of flagellum biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. - positive regulation of glycogen anabolism - positive regulation of glycogen biosynthesis - positive regulation of glycogen formation - positive regulation of glycogen synthesis - up regulation of glycogen biosynthetic process - up-regulation of glycogen biosynthetic process - upregulation of glycogen biosynthetic process - activation of glycogen biosynthetic process - stimulation of glycogen biosynthetic process - biological_process - GO:0045725 - positive regulation of glycogen biosynthetic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. - GO:0045946 - positive regulation of protein anabolism - positive regulation of protein biosynthesis - positive regulation of protein biosynthetic process - positive regulation of protein formation - positive regulation of protein synthesis - up regulation of protein biosynthetic process - up-regulation of protein biosynthetic process - upregulation of protein biosynthetic process - activation of protein biosynthetic process - stimulation of protein biosynthetic process - biological_process - GO:0045727 - positive regulation of translation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. - GOC:dph - GOC:go_curators - GOC:tb - - - - - positive regulation of protein biosynthetic process - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. - https://github.com/geneontology/go-ontology/issues/23112 - GO:1903364 - GO:2000600 - positive regulation of cellular protein breakdown - positive regulation of cellular protein catabolic process - positive regulation of cellular protein catabolism - positive regulation of cellular protein degradation - positive regulation of protein breakdown - positive regulation of protein catabolism - positive regulation of protein degradation - up regulation of cellular protein breakdown - up regulation of cellular protein catabolic process - up regulation of cellular protein catabolism - up regulation of cellular protein degradation - up regulation of protein catabolic process - up-regulation of cellular protein breakdown - up-regulation of cellular protein catabolic process - up-regulation of cellular protein catabolism - up-regulation of cellular protein degradation - up-regulation of protein catabolic process - upregulation of cellular protein breakdown - upregulation of cellular protein catabolic process - upregulation of cellular protein catabolism - upregulation of cellular protein degradation - upregulation of protein catabolic process - activation of cellular protein breakdown - activation of cellular protein catabolic process - activation of cellular protein catabolism - activation of cellular protein degradation - activation of protein catabolic process - positive regulation of cyclin breakdown - positive regulation of cyclin catabolic process - positive regulation of cyclin catabolism - positive regulation of cyclin degradation - positive regulation of degradation of cyclin - stimulation of protein catabolic process - biological_process - GO:0045732 - positive regulation of protein catabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. - GOC:go_curators - - - - - positive regulation of cellular protein breakdown - GOC:TermGenie - - - - - positive regulation of cellular protein catabolism - GOC:TermGenie - - - - - positive regulation of cellular protein degradation - GOC:TermGenie - - - - - up regulation of cellular protein breakdown - GOC:TermGenie - - - - - up regulation of cellular protein catabolic process - GOC:TermGenie - - - - - up regulation of cellular protein catabolism - GOC:TermGenie - - - - - up regulation of cellular protein degradation - GOC:TermGenie - - - - - up-regulation of cellular protein breakdown - GOC:TermGenie - - - - - up-regulation of cellular protein catabolic process - GOC:TermGenie - - - - - up-regulation of cellular protein catabolism - GOC:TermGenie - - - - - up-regulation of cellular protein degradation - GOC:TermGenie - - - - - upregulation of cellular protein breakdown - GOC:TermGenie - - - - - upregulation of cellular protein catabolic process - GOC:TermGenie - - - - - upregulation of cellular protein catabolism - GOC:TermGenie - - - - - upregulation of cellular protein degradation - GOC:TermGenie - - - - - activation of cellular protein breakdown - GOC:TermGenie - - - - - activation of cellular protein catabolic process - GOC:TermGenie - - - - - activation of cellular protein catabolism - GOC:TermGenie - - - - - activation of cellular protein degradation - GOC:TermGenie - - - - - positive regulation of cyclin breakdown - GOC:obol - - - - - positive regulation of cyclin catabolism - GOC:obol - - - - - positive regulation of cyclin degradation - GOC:obol - - - - - positive regulation of degradation of cyclin - GOC:obol - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid. - GO:0019663 - acetate breakdown - acetate catabolism - acetate degradation - biological_process - homoacetate catabolic process - GO:0045733 - acetate catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid. - regulation of acetate breakdown - regulation of acetate catabolism - regulation of acetate degradation - biological_process - GO:0045734 - regulation of acetate catabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate. - down regulation of acetate catabolic process - down-regulation of acetate catabolic process - downregulation of acetate catabolic process - negative regulation of acetate breakdown - negative regulation of acetate catabolism - negative regulation of acetate degradation - inhibition of acetate catabolic process - biological_process - GO:0045753 - negative regulation of acetate catabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate. - positive regulation of acetate breakdown - positive regulation of acetate catabolism - positive regulation of acetate degradation - up regulation of acetate catabolic process - up-regulation of acetate catabolic process - upregulation of acetate catabolic process - activation of acetate catabolic process - stimulation of acetate catabolic process - biological_process - GO:0045754 - positive regulation of acetate catabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. - down regulation of action potential - down-regulation of action potential - downregulation of action potential - inhibition of action potential - biological_process - GO:0045759 - negative regulation of action potential - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. - up regulation of action potential - up-regulation of action potential - upregulation of action potential - activation of action potential - stimulation of action potential - biological_process - GO:0045760 - positive regulation of action potential - - - - - Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid. - down regulation of amino acid metabolic process - down-regulation of amino acid metabolic process - downregulation of amino acid metabolic process - negative regulation of amino acid metabolism - inhibition of amino acid metabolic process - biological_process - GO:0045763 - negative regulation of cellular amino acid metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid. - positive regulation of amino acid metabolism - positive regulation of cellular amino acid metabolic process - up regulation of amino acid metabolic process - up-regulation of amino acid metabolic process - upregulation of amino acid metabolic process - activation of amino acid metabolic process - stimulation of amino acid metabolic process - biological_process - GO:0045764 - positive regulation of amino acid metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of angiogenesis. - biological_process - GO:0045765 - regulation of angiogenesis - - - - - Any process that modulates the frequency, rate or extent of angiogenesis. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases angiogenesis. - up regulation of angiogenesis - up-regulation of angiogenesis - upregulation of angiogenesis - activation of angiogenesis - stimulation of angiogenesis - biological_process - GO:0045766 - positive regulation of angiogenesis - - - - - Any process that activates or increases angiogenesis. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division. - down regulation of asymmetric cell division - down-regulation of asymmetric cell division - downregulation of asymmetric cell division - inhibition of asymmetric cell division - biological_process - GO:0045769 - negative regulation of asymmetric cell division - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of asymmetric cell division. - up regulation of asymmetric cell division - up-regulation of asymmetric cell division - upregulation of asymmetric cell division - activation of asymmetric cell division - stimulation of asymmetric cell division - biological_process - GO:0045770 - positive regulation of asymmetric cell division - - - - - Any process that activates or increases the frequency, rate or extent of asymmetric cell division. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. - positive regulation of bone biosynthesis - positive regulation of bone formation - up regulation of ossification - up-regulation of ossification - upregulation of ossification - activation of ossification - stimulation of ossification - biological_process - GO:0045778 - positive regulation of ossification - - - - - Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. - down regulation of progression through cell cycle - down-regulation of progression through cell cycle - downregulation of progression through cell cycle - negative regulation of cell cycle progression - negative regulation of progression through cell cycle - inhibition of progression through cell cycle - biological_process - GO:0045786 - negative regulation of cell cycle - - - - - Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. - GOC:dph - GOC:go_curators - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the rate or extent of progression through the cell cycle. - positive regulation of cell cycle progression - positive regulation of progression through cell cycle - up regulation of progression through cell cycle - up-regulation of progression through cell cycle - upregulation of progression through cell cycle - activation of progression through cell cycle - stimulation of progression through cell cycle - biological_process - GO:0045787 - positive regulation of cell cycle - - - - - Any process that activates or increases the rate or extent of progression through the cell cycle. - GOC:go_curators - - - - - positive regulation of progression through cell cycle - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. - down regulation of glycogen catabolic process - down-regulation of glycogen catabolic process - downregulation of glycogen catabolic process - negative regulation of glycogen breakdown - negative regulation of glycogen catabolism - negative regulation of glycogen degradation - negative regulation of glycogenolysis - inhibition of glycogen catabolic process - biological_process - GO:0045818 - negative regulation of glycogen catabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. - GOC:go_curators - - - - - negative regulation of glycogenolysis - GOC:sl - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. - positive regulation of glycogen breakdown - positive regulation of glycogen catabolism - positive regulation of glycogen degradation - positive regulation of glycogenolysis - up regulation of glycogen catabolic process - up-regulation of glycogen catabolic process - upregulation of glycogen catabolic process - activation of glycogen catabolic process - stimulation of glycogen catabolic process - biological_process - GO:0045819 - positive regulation of glycogen catabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. - GOC:go_curators - - - - - positive regulation of glycogenolysis - GOC:sl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. - down regulation of heart contraction - down-regulation of heart contraction - downregulation of heart contraction - inhibition of heart contraction - biological_process - negative regulation of cardiac contraction - GO:0045822 - negative regulation of heart contraction - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of heart contraction. - positive regulation of cardiac contraction - up regulation of heart contraction - up-regulation of heart contraction - upregulation of heart contraction - activation of heart contraction - stimulation of heart contraction - biological_process - GO:0045823 - positive regulation of heart contraction - - - - - Any process that activates or increases the frequency, rate or extent of heart contraction. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. - down regulation of lipid metabolic process - down-regulation of lipid metabolic process - downregulation of lipid metabolic process - negative regulation of lipid metabolism - inhibition of lipid metabolic process - biological_process - GO:0045833 - negative regulation of lipid metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. - positive regulation of lipid metabolism - up regulation of lipid metabolic process - up-regulation of lipid metabolic process - upregulation of lipid metabolic process - activation of lipid metabolic process - stimulation of lipid metabolic process - biological_process - GO:0045834 - positive regulation of lipid metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. - down regulation of meiosis - down-regulation of meiosis - downregulation of meiosis - negative regulation of meiosis - inhibition of meiosis - biological_process - GO:0045835 - negative regulation of meiotic nuclear division - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of meiosis. - positive regulation of meiosis - up regulation of meiosis - up-regulation of meiosis - upregulation of meiosis - activation of meiosis - stimulation of meiosis - biological_process - GO:0045836 - positive regulation of meiotic nuclear division - - - - - Any process that activates or increases the frequency, rate or extent of meiosis. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. - down regulation of mitosis - down-regulation of mitosis - downregulation of mitosis - negative regulation of mitosis - inhibition of mitosis - biological_process - GO:0045839 - negative regulation of mitotic nuclear division - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. - GOC:dph - GOC:go_curators - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of mitosis. - positive regulation of mitosis - up regulation of mitosis - up-regulation of mitosis - upregulation of mitosis - activation of mitosis - mitogenic activity - stimulation of mitosis - biological_process - GO:0045840 - positive regulation of mitotic nuclear division - - - - - Any process that activates or increases the frequency, rate or extent of mitosis. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development. - down regulation of striated muscle development - down-regulation of striated muscle development - downregulation of striated muscle development - inhibition of striated muscle development - biological_process - GO:0045843 - negative regulation of striated muscle tissue development - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of striated muscle development. - up regulation of striated muscle development - up-regulation of striated muscle development - upregulation of striated muscle development - activation of striated muscle development - stimulation of striated muscle development - biological_process - GO:0045844 - positive regulation of striated muscle tissue development - - - - - Any process that activates or increases the frequency, rate or extent of striated muscle development. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation. - down regulation of translational elongation - down-regulation of translational elongation - downregulation of translational elongation - inhibition of translational elongation - biological_process - GO:0045900 - negative regulation of translational elongation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of translational elongation. - up regulation of translational elongation - up-regulation of translational elongation - upregulation of translational elongation - activation of translational elongation - stimulation of translational elongation - biological_process - GO:0045901 - positive regulation of translational elongation - - - - - Any process that activates or increases the frequency, rate or extent of translational elongation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination. - down regulation of translational termination - down-regulation of translational termination - downregulation of translational termination - inhibition of translational termination - biological_process - GO:0045904 - negative regulation of translational termination - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of translational termination. - up regulation of translational termination - up-regulation of translational termination - upregulation of translational termination - activation of translational termination - stimulation of translational termination - biological_process - GO:0045905 - positive regulation of translational termination - - - - - Any process that activates or increases the frequency, rate or extent of translational termination. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. - down regulation of carbohydrate metabolic process - down-regulation of carbohydrate metabolic process - downregulation of carbohydrate metabolic process - negative regulation of carbohydrate metabolism - inhibition of carbohydrate metabolic process - biological_process - GO:0045912 - negative regulation of carbohydrate metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. - positive regulation of carbohydrate metabolism - up regulation of carbohydrate metabolic process - up-regulation of carbohydrate metabolic process - upregulation of carbohydrate metabolic process - activation of carbohydrate metabolic process - stimulation of carbohydrate metabolic process - biological_process - GO:0045913 - positive regulation of carbohydrate metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. - down regulation of catecholamine metabolic process - down-regulation of catecholamine metabolic process - downregulation of catecholamine metabolic process - negative regulation of catecholamine metabolism - inhibition of catecholamine metabolic process - biological_process - GO:0045914 - negative regulation of catecholamine metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. - positive regulation of catecholamine metabolism - up regulation of catecholamine metabolic process - up-regulation of catecholamine metabolic process - upregulation of catecholamine metabolic process - activation of catecholamine metabolic process - stimulation of catecholamine metabolic process - biological_process - GO:0045915 - positive regulation of catecholamine metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. - down regulation of exocytosis - down-regulation of exocytosis - downregulation of exocytosis - inhibition of exocytosis - biological_process - GO:0045920 - negative regulation of exocytosis - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of exocytosis. - up regulation of exocytosis - up-regulation of exocytosis - upregulation of exocytosis - activation of exocytosis - stimulation of exocytosis - biological_process - GO:0045921 - positive regulation of exocytosis - - - - - Any process that activates or increases the frequency, rate or extent of exocytosis. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. - down regulation of growth - down-regulation of growth - downregulation of growth - inhibition of growth - biological_process - GO:0045926 - negative regulation of growth - - - - - Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. - up regulation of growth - up-regulation of growth - upregulation of growth - activation of growth - stimulation of growth - biological_process - GO:0045927 - positive regulation of growth - - - - - Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. - down regulation of progression through mitotic cell cycle - down-regulation of progression through mitotic cell cycle - downregulation of progression through mitotic cell cycle - negative regulation of mitotic cell cycle progression - negative regulation of progression through mitotic cell cycle - inhibition of progression through mitotic cell cycle - biological_process - GO:0045930 - negative regulation of mitotic cell cycle - - - - - Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. - GOC:dph - GOC:go_curators - GOC:tb - - - - - negative regulation of progression through mitotic cell cycle - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. - positive regulation of mitotic cell cycle progression - positive regulation of progression through mitotic cell cycle - up regulation of progression through mitotic cell cycle - up-regulation of progression through mitotic cell cycle - upregulation of progression through mitotic cell cycle - activation of progression through mitotic cell cycle - stimulation of progression through mitotic cell cycle - biological_process - GO:0045931 - positive regulation of mitotic cell cycle - - - - - Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. - GOC:dph - GOC:go_curators - GOC:tb - - - - - positive regulation of progression through mitotic cell cycle - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. - down regulation of muscle contraction - down-regulation of muscle contraction - downregulation of muscle contraction - inhibition of muscle contraction - biological_process - GO:0045932 - negative regulation of muscle contraction - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of muscle contraction. - up regulation of muscle contraction - up-regulation of muscle contraction - upregulation of muscle contraction - activation of muscle contraction - stimulation of muscle contraction - biological_process - GO:0045933 - positive regulation of muscle contraction - - - - - Any process that activates or increases the frequency, rate or extent of muscle contraction. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. - down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism - inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - biological_process - negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - GO:0045934 - negative regulation of nucleobase-containing compound metabolic process - - - - - Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. - GOC:go_curators - - - - - negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. - positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism - up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - biological_process - positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - GO:0045935 - positive regulation of nucleobase-containing compound metabolic process - - - - - Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. - GOC:go_curators - - - - - positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates. - down regulation of phosphate metabolic process - down-regulation of phosphate metabolic process - downregulation of phosphate metabolic process - negative regulation of phosphate metabolism - inhibition of phosphate metabolic process - biological_process - GO:0045936 - negative regulation of phosphate metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates. - positive regulation of phosphate metabolism - up regulation of phosphate metabolic process - up-regulation of phosphate metabolic process - upregulation of phosphate metabolic process - activation of phosphate metabolic process - stimulation of phosphate metabolic process - biological_process - GO:0045937 - positive regulation of phosphate metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. - down regulation of steroid metabolic process - down-regulation of steroid metabolic process - downregulation of steroid metabolic process - negative regulation of steroid metabolism - inhibition of steroid metabolic process - biological_process - GO:0045939 - negative regulation of steroid metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. - positive regulation of steroid metabolism - up regulation of steroid metabolic process - up-regulation of steroid metabolic process - upregulation of steroid metabolic process - activation of steroid metabolic process - stimulation of steroid metabolic process - biological_process - GO:0045940 - positive regulation of steroid metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. - down regulation of translational initiation - down-regulation of translational initiation - downregulation of translational initiation - inhibition of translational initiation - biological_process - GO:0045947 - negative regulation of translational initiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of translational initiation. - up regulation of translational initiation - up-regulation of translational initiation - upregulation of translational initiation - activation of translational initiation - stimulation of translational initiation - biological_process - GO:0045948 - positive regulation of translational initiation - - - - - Any process that activates or increases the frequency, rate or extent of translational initiation. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. - down regulation of smooth muscle contraction - down-regulation of smooth muscle contraction - downregulation of smooth muscle contraction - inhibition of smooth muscle contraction - biological_process - smooth muscle relaxation - GO:0045986 - negative regulation of smooth muscle contraction - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. - up regulation of smooth muscle contraction - up-regulation of smooth muscle contraction - upregulation of smooth muscle contraction - activation of smooth muscle contraction - stimulation of smooth muscle contraction - biological_process - GO:0045987 - positive regulation of smooth muscle contraction - - - - - Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction. - down regulation of striated muscle contraction - down-regulation of striated muscle contraction - downregulation of striated muscle contraction - inhibition of striated muscle contraction - biological_process - GO:0045988 - negative regulation of striated muscle contraction - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of striated muscle contraction. - up regulation of striated muscle contraction - up-regulation of striated muscle contraction - upregulation of striated muscle contraction - activation of striated muscle contraction - stimulation of striated muscle contraction - biological_process - GO:0045989 - positive regulation of striated muscle contraction - - - - - Any process that activates or increases the frequency, rate or extent of striated muscle contraction. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. - down regulation of embryonic development - down-regulation of embryonic development - downregulation of embryonic development - inhibition of embryonic development - biological_process - GO:0045992 - negative regulation of embryonic development - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of embryonic development. - biological_process - GO:0045995 - regulation of embryonic development - - - - - Any process that modulates the frequency, rate or extent of embryonic development. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. - nucleobase anabolism - nucleobase biosynthesis - nucleobase formation - nucleobase synthesis - biological_process - GO:0046112 - nucleobase biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. - nucleobase breakdown - nucleobase catabolism - nucleobase degradation - biological_process - GO:0046113 - nucleobase catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. - phenol-containing compound anabolism - phenol-containing compound biosynthesis - phenol-containing compound formation - phenol-containing compound synthesis - biological_process - GO:0046189 - phenol-containing compound biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. - indolalkylamine anabolism - indolalkylamine biosynthesis - indolalkylamine formation - indolalkylamine synthesis - biological_process - GO:0046219 - indolalkylamine biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. - GOC:curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. - monosaccharide anabolism - monosaccharide biosynthesis - monosaccharide formation - monosaccharide synthesis - biological_process - GO:0046364 - monosaccharide biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. - monosaccharide breakdown - monosaccharide catabolism - monosaccharide degradation - biological_process - GO:0046365 - monosaccharide catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. - carboxylic acid anabolism - carboxylic acid biosynthesis - carboxylic acid formation - carboxylic acid synthesis - biological_process - GO:0046394 - carboxylic acid biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. - carboxylic acid breakdown - carboxylic acid catabolism - carboxylic acid degradation - biological_process - GO:0046395 - carboxylic acid catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). - heterocycle metabolism - biological_process - GO:0046483 - - heterocycle metabolic process - - - - - The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. - GO:0007467 - biological_process - GO:0046530 - photoreceptor cell differentiation - - - - - The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. - GOC:ai - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. - GO:0045673 - regulation of photoreceptor differentiation - biological_process - GO:0046532 - regulation of photoreceptor cell differentiation - - - - - Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. - GO:0045674 - down regulation of photoreceptor cell differentiation - down regulation of photoreceptor differentiation - down-regulation of photoreceptor cell differentiation - down-regulation of photoreceptor differentiation - downregulation of photoreceptor cell differentiation - downregulation of photoreceptor differentiation - negative regulation of photoreceptor differentiation - inhibition of photoreceptor cell differentiation - inhibition of photoreceptor differentiation - biological_process - GO:0046533 - negative regulation of photoreceptor cell differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. - GO:0045675 - positive regulation of photoreceptor differentiation - up regulation of photoreceptor cell differentiation - up regulation of photoreceptor differentiation - up-regulation of photoreceptor cell differentiation - up-regulation of photoreceptor differentiation - upregulation of photoreceptor cell differentiation - upregulation of photoreceptor differentiation - activation of photoreceptor cell differentiation - activation of photoreceptor differentiation - stimulation of photoreceptor cell differentiation - stimulation of photoreceptor differentiation - biological_process - GO:0046534 - positive regulation of photoreceptor cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. - GOC:go_curators - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion. - biological_process - GO:0046545 - development of primary female sexual characteristics - - - - - The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light. - biological_process - GO:0046548 - retinal rod cell development - - - - - Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision. - biological_process - GO:0046549 - retinal cone cell development - - - - - Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of growth of an organ of an organism. - biological_process - GO:0046620 - regulation of organ growth - - - - - Any process that modulates the frequency, rate or extent of growth of an organ of an organism. - GOC:bf - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism. - biological_process - GO:0046621 - negative regulation of organ growth - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism. - GOC:bf - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. - biological_process - GO:0046622 - positive regulation of organ growth - - - - - Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. - GOC:bf - GOC:tb - - - - - - - - - - - - - - - The establishment of the sex of a female organism by physical differentiation. - biological_process - GO:0046660 - female sex differentiation - - - - - The establishment of the sex of a female organism by physical differentiation. - GOC:bf - - - - - - - - - - - - - - - Programmed cell death that occurs in the developing retina. - programmed cell death, retina cells - programmed cell death, retinal cells - retina cell programmed cell death - retina programmed cell death - retinal programmed cell death - biological_process - GO:0046666 - retinal cell programmed cell death - - - - - Programmed cell death that occurs in the developing retina. - GOC:bf - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium. - biological_process - GO:0046667 - compound eye retinal cell programmed cell death - - - - - Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium. - PMID:12006672 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina. - regulation of retinal programmed cell death - biological_process - GO:0046668 - regulation of retinal cell programmed cell death - - - - - Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina. - GOC:ai - GOC:tb - - - - - regulation of retinal programmed cell death - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. - regulation of retinal cell programmed cell death - biological_process - GO:0046669 - regulation of compound eye retinal cell programmed cell death - - - - - Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina. - positive regulation of retinal programmed cell death - up regulation of retinal programmed cell death - up-regulation of retinal programmed cell death - upregulation of retinal programmed cell death - activation of retinal programmed cell death - stimulation of retinal programmed cell death - biological_process - GO:0046670 - positive regulation of retinal cell programmed cell death - - - - - Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina. - GOC:ai - GOC:tb - - - - - positive regulation of retinal programmed cell death - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina. - down regulation of retinal programmed cell death - down-regulation of retinal programmed cell death - downregulation of retinal programmed cell death - negative regulation of retinal programmed cell death - inhibition of retinal programmed cell death - biological_process - GO:0046671 - negative regulation of retinal cell programmed cell death - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina. - GOC:ai - GOC:tb - - - - - negative regulation of retinal programmed cell death - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. - activation of retinal cell programmed cell death - positive regulation of retinal cell programmed cell death - stimulation of retinal cell programmed cell death - up regulation of retinal cell programmed cell death - up-regulation of retinal cell programmed cell death - upregulation of retinal cell programmed cell death - biological_process - GO:0046672 - positive regulation of compound eye retinal cell programmed cell death - - - - - Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. - down regulation of retinal cell programmed cell death - down-regulation of retinal cell programmed cell death - downregulation of retinal cell programmed cell death - inhibition of retinal cell programmed cell death - negative regulation of retina cell programmed cell death - negative regulation of retinal cell programmed cell death - biological_process - GO:0046673 - negative regulation of compound eye retinal cell programmed cell death - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. - down regulation of insulin secretion - down-regulation of insulin secretion - downregulation of insulin secretion - inhibition of insulin secretion - biological_process - GO:0046676 - negative regulation of insulin secretion - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase. - biological_process - carbamate resistance - carbamate susceptibility/resistance - GO:0046681 - response to carbamate - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase. - ISBN:0721662544 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). - heterocycle breakdown - heterocycle catabolism - heterocycle degradation - biological_process - GO:0046700 - heterocycle catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. - https://github.com/geneontology/go-ontology/issues/24218 - - muscle fiber maintenance - biological_process - muscle homeostasis - GO:0046716 - muscle cell cellular homeostasis - - - - - The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. - GOC:mah - PMID:3091429 - PMID:7781901 - - - - - muscle fiber maintenance - GOC:dph - GOC:tb - - - - - muscle homeostasis - GOC:dph - - - - - - - - - The controlled release of acid by a cell or a tissue. - biological_process - GO:0046717 - acid secretion - - - - - The controlled release of acid by a cell or a tissue. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The addition of tubulin heterodimers to one or both ends of a microtubule. - microtubule assembly - biological_process - microtubule formation - GO:0046785 - microtubule polymerization - - - - - The addition of tubulin heterodimers to one or both ends of a microtubule. - GOC:ai - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of metal ions from one side of a membrane to the other. - heavy metal ion porter activity - heavy metal ion transporter activity - heavy metal ion:hydrogen symporter activity - heavy metal-exporting ATPase activity - high affinity metal ion uptake transporter activity - low affinity metal ion uptake transporter activity - molecular_function - GO:0046873 - metal ion transmembrane transporter activity - - - - - Enables the transfer of metal ions from one side of a membrane to the other. - GOC:ai - - - - - - - - - - The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. - biological_process - GO:0046879 - hormone secretion - - - - - The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. - biological_process - GO:0046883 - regulation of hormone secretion - - - - - Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. - up regulation of hormone secretion - up-regulation of hormone secretion - upregulation of hormone secretion - activation of hormone secretion - stimulation of hormone secretion - biological_process - GO:0046887 - positive regulation of hormone secretion - - - - - Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. - down regulation of hormone secretion - down-regulation of hormone secretion - downregulation of hormone secretion - inhibition of hormone secretion - biological_process - GO:0046888 - negative regulation of hormone secretion - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. - positive regulation of lipid anabolism - positive regulation of lipid biosynthesis - positive regulation of lipid formation - positive regulation of lipid synthesis - positive regulation of lipogenesis - up regulation of lipid biosynthetic process - up-regulation of lipid biosynthetic process - upregulation of lipid biosynthetic process - activation of lipid biosynthetic process - stimulation of lipid biosynthetic process - biological_process - GO:0046889 - positive regulation of lipid biosynthetic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. - GOC:ai - - - - - positive regulation of lipogenesis - GOC:sl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. - regulation of lipid anabolism - regulation of lipid biosynthesis - regulation of lipid formation - regulation of lipid synthesis - regulation of lipogenesis - biological_process - GO:0046890 - regulation of lipid biosynthetic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. - GOC:ai - - - - - regulation of lipogenesis - GOC:sl - - - - - - - - - The controlled release of a substance by a cell or a tissue. - biological_process - GO:0046903 - - secretion - - - - - The controlled release of a substance by a cell or a tissue. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of substances within a cell. - jl - 2013-12-18T14:04:50Z - GO:1902582 - biological_process - single organism intracellular transport - single-organism intracellular transport - GO:0046907 - intracellular transport - - - - - The directed movement of substances within a cell. - GOC:ai - - - - - single organism intracellular transport - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell. - biological_process - GO:0046928 - regulation of neurotransmitter secretion - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter. - down regulation of neurotransmitter secretion - down-regulation of neurotransmitter secretion - downregulation of neurotransmitter secretion - conotoxin activity - inhibition of neurotransmitter secretion - biological_process - GO:0046929 - negative regulation of neurotransmitter secretion - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). - biological_process - GO:0046942 - carboxylic acid transport - - - - - The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). - Reactome:R-HSA-390347 - molecular_function - GO:0046943 - carboxylic acid transmembrane transporter activity - - - - - Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). - GOC:ai - - - - - Reactome:R-HSA-390347 - Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. - microtubule-based vesicle localization - biological_process - GO:0047496 - vesicle transport along microtubule - - - - - The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. - GOC:ecd - GOC:rl - - - - - microtubule-based vesicle localization - GOC:rl - - - - - - - - - - The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. - biological_process - GO:0048048 - embryonic eye morphogenesis - - - - - The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. - GOC:jid - - - - - - - - - The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. - biological_process - pigmentation during development - GO:0048066 - developmental pigmentation - - - - - The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. - ISBN:0582227089 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. - regulation of pigmentation during development - biological_process - GO:0048070 - regulation of developmental pigmentation - - - - - Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. - GOC:dph - GOC:jid - GOC:tb - - - - - regulation of pigmentation during development - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. - down regulation of developmental pigmentation - down-regulation of developmental pigmentation - downregulation of developmental pigmentation - inhibition of pigmentation - biological_process - GO:0048086 - negative regulation of developmental pigmentation - - - - - Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. - GOC:dph - GOC:jid - GOC:tb - - - - - down regulation of developmental pigmentation - GOC:dph - GOC:tb - - - - - down-regulation of developmental pigmentation - GOC:dph - GOC:tb - - - - - downregulation of developmental pigmentation - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. - up regulation of developmental pigmentation - up-regulation of developmental pigmentation - upregulation of developmental pigmentation - activation of developmental pigmentation - stimulation of developmental pigmentation - biological_process - GO:0048087 - positive regulation of developmental pigmentation - - - - - Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. - GOC:dph - GOC:jid - GOC:tb - - - - - up regulation of developmental pigmentation - GOC:dph - - - - - up-regulation of developmental pigmentation - GOC:dph - GOC:tb - - - - - upregulation of developmental pigmentation - GOC:dph - GOC:tb - - - - - activation of developmental pigmentation - GOC:dph - GOC:tb - - - - - stimulation of developmental pigmentation - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. - somatic stem cell renewal - biological_process - GO:0048103 - somatic stem cell division - - - - - The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. - GOC:jid - ISBN:0582227089 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes. - GO:0048141 - female germ-line stem cell renewal - biological_process - GO:0048132 - female germ-line stem cell asymmetric division - - - - - The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes. - GOC:jid - GOC:mtg_sensu - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population. - biological_process - GO:0048144 - fibroblast proliferation - - - - - The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. - biological_process - GO:0048145 - regulation of fibroblast proliferation - - - - - Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. - up regulation of fibroblast proliferation - up-regulation of fibroblast proliferation - upregulation of fibroblast proliferation - activation of fibroblast proliferation - stimulation of fibroblast proliferation - biological_process - GO:0048146 - positive regulation of fibroblast proliferation - - - - - Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. - down regulation of fibroblast proliferation - down-regulation of fibroblast proliferation - downregulation of fibroblast proliferation - inhibition of fibroblast proliferation - biological_process - GO:0048147 - negative regulation of fibroblast proliferation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. - biological_process - Golgi-derived vesicle transport - GO:0048193 - - Golgi vesicle transport - - - - - The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. - GOC:jid - ISBN:0716731363 - PMID:10219233 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation. - Golgi vesicle targeting - dictyosome vesicle targeting - vesicle targeting, to, from or within dictyosome - biological_process - GO:0048199 - vesicle targeting, to, from or within Golgi - - - - - The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation. - GOC:jid - GOC:mah - ISBN:0716731363 - PMID:10219233 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus. - regulation of Golgi vesicle targeting - biological_process - GO:0048209 - regulation of vesicle targeting, to, from or within Golgi - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus. - GOC:jid - GOC:mah - ISBN:0716731363 - PMID:10219233 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system. - noradrenaline secretion - biological_process - GO:0048243 - norepinephrine secretion - - - - - The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system. - GOC:ef - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching. - elastic fibre assembly - elastin fiber assembly - elastin fibre assembly - biological_process - GO:0048251 - elastic fiber assembly - - - - - Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching. - GOC:jid - PMID:10841810 - PMID:12615674 - - - - - elastin fiber assembly - GOC:BHF - - - - - elastin fibre assembly - GOC:BHF - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. - biological_process - GO:0048280 - vesicle fusion with Golgi apparatus - - - - - The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - The creation of a single organelle from two or more organelles. - biological_process - GO:0048284 - - - organelle fusion - - - - - The creation of a single organelle from two or more organelles. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - The creation of two or more organelles by division of one organelle. - biological_process - GO:0048285 - - - organelle fission - - - - - The creation of two or more organelles by division of one organelle. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei. - biological_process - nuclear membrane fusion during karyogamy - GO:0048288 - nuclear membrane fusion involved in karyogamy - - - - - The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei. - GOC:jid - - - - - nuclear membrane fusion during karyogamy - GOC:dph - GOC:tb - - - - - - - - - The partitioning of organelles between daughter cells at cell division. - biological_process - GO:0048308 - - - organelle inheritance - - - - - The partitioning of organelles between daughter cells at cell division. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - The partitioning of Golgi apparatus between daughter cells at cell division. - Golgi apparatus inheritance - Golgi division - Golgi partitioning - biological_process - GO:0048313 - Golgi inheritance - - - - - The partitioning of Golgi apparatus between daughter cells at cell division. - GOC:jid - PMID:12851069 - - - - - Golgi division - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. - biological_process - GO:0048318 - axial mesoderm development - - - - - The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. - GOC:dgh - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the axial mesoderm are generated and organized. - biological_process - GO:0048319 - axial mesoderm morphogenesis - - - - - The process in which the anatomical structures of the axial mesoderm are generated and organized. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. - biological_process - GO:0048320 - axial mesoderm formation - - - - - The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. - GOC:dgh - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the mesoderm are generated and organized. - biological_process - GO:0048332 - mesoderm morphogenesis - - - - - The process in which the anatomical structures of the mesoderm are generated and organized. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. - mesoderm cell differentiation - biological_process - GO:0048333 - mesodermal cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. - GOC:dgh - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. - biological_process - GO:0048339 - paraxial mesoderm development - - - - - The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. - GOC:dgh - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the paraxial mesoderm are generated and organized. - biological_process - GO:0048340 - paraxial mesoderm morphogenesis - - - - - The process in which the anatomical structures of the paraxial mesoderm are generated and organized. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. - biological_process - GO:0048341 - paraxial mesoderm formation - - - - - The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. - GOC:dgh - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. - lateral plate mesoderm development - biological_process - GO:0048368 - lateral mesoderm development - - - - - The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the lateral mesoderm are generated and organized. - lateral plate mesoderm morphogenesis - biological_process - GO:0048369 - lateral mesoderm morphogenesis - - - - - The process in which the anatomical structures of the lateral mesoderm are generated and organized. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts. - lateral plate mesoderm biosynthesis - lateral plate mesoderm formation - biological_process - GO:0048370 - lateral mesoderm formation - - - - - The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. - biological_process - GO:0048389 - intermediate mesoderm development - - - - - The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. - GOC:dgh - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the intermediate mesoderm are generated and organized. - biological_process - GO:0048390 - intermediate mesoderm morphogenesis - - - - - The process in which the anatomical structures of the intermediate mesoderm are generated and organized. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts. - biological_process - GO:0048391 - intermediate mesoderm formation - - - - - The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts. - GOC:dgh - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place. - https://github.com/geneontology/go-ontology/issues/24390 - biological_process - terminal differentiation - GO:0048468 - - cell development - - - - - The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place. - GOC:go_curators - - - - - terminal differentiation - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state. - https://github.com/geneontology/go-ontology/issues/24390 - biological_process - functional differentiation - GO:0048469 - - cell maturation - - - - - The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state. - GOC:go_curators - - - - - functional differentiation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. - GO:0009993 - GO:0048157 - Wikipedia:Oogenesis - ovum development - biological_process - GO:0048477 - oogenesis - - - - - The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. - GOC:kmv - GOC:mtg_sensu - GOC:pr - - - - - ovum development - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. - biological_process - GO:0048483 - autonomic nervous system development - - - - - The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. - FMA:9905 - GOC:jid - GOC:sr - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. - biological_process - GO:0048485 - sympathetic nervous system development - - - - - The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. - FMA:9906 - GOC:jid - GOC:sr - - - - - - - - - - The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development. - biological_process - timing of cell differentiation - GO:0048505 - regulation of timing of cell differentiation - - - - - The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development. - GOC:bf - GOC:dph - GOC:jid - GOC:tb - - - - - - - - - Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. - https://github.com/geneontology/go-ontology/issues/25943 - Wikipedia:Organogenesis - development of an organ - organogenesis - biological_process - GO:0048513 - animal organ development - - - - - Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. - GOC:dph - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. - biological_process - GO:0048514 - blood vessel morphogenesis - - - - - The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - GO:0043119 - positive regulation of physiological process - up regulation of biological process - up-regulation of biological process - upregulation of biological process - activation of biological process - stimulation of biological process - biological_process - GO:0048518 - - positive regulation of biological process - - - - - Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - GO:0043118 - down regulation of biological process - down-regulation of biological process - downregulation of biological process - negative regulation of physiological process - inhibition of biological process - biological_process - GO:0048519 - - negative regulation of biological process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. - up regulation of behavior - up-regulation of behavior - upregulation of behavior - activation of behavior - stimulation of behavior - biological_process - GO:0048520 - positive regulation of behavior - - - - - Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. - GOC:jid - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. - down regulation of behavior - down-regulation of behavior - downregulation of behavior - inhibition of behavior - biological_process - GO:0048521 - negative regulation of behavior - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. - GOC:jid - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GO:0051242 - positive regulation of cellular physiological process - up regulation of cellular process - up-regulation of cellular process - upregulation of cellular process - activation of cellular process - stimulation of cellular process - biological_process - GO:0048522 - - positive regulation of cellular process - - - - - Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GO:0051243 - down regulation of cellular process - down-regulation of cellular process - downregulation of cellular process - negative regulation of cellular physiological process - inhibition of cellular process - biological_process - GO:0048523 - - negative regulation of cellular process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GOC:jid - - - - - - - - - - - - - - - The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. - haematopoietic or lymphoid organ development - haemopoietic or lymphoid organ development - hemopoietic or lymphoid organ development - biological_process - GO:0048534 - hematopoietic or lymphoid organ development - - - - - The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. - GOC:add - GOC:rl - ISBN:0781735149 - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. - biological_process - GO:0048536 - spleen development - - - - - The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. - GOC:add - ISBN:0781735149 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure. - biological_process - GO:0048539 - bone marrow development - - - - - The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure. - GOC:add - ISBN:0781735149 - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. - response to steroid hormone stimulus - biological_process - GO:0048545 - response to steroid hormone - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. - GOC:go_curators - - - - - response to steroid hormone stimulus - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. - GO:0048547 - gut morphogenesis - alimentary canal morphogenesis - digestive tube morphogenesis - gastrointestinal tract morphogenesis - intestinal morphogenesis - biological_process - GO:0048546 - digestive tract morphogenesis - - - - - The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. - GOC:dph - GOC:go_curators - PMID:12618131 - - - - - gut morphogenesis - GOC:dph - - - - - - - - - - - - - - - - Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. - biological_process - GO:0048562 - embryonic organ morphogenesis - - - - - Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. - gut development - intestinal development - intestine development - biological_process - GO:0048565 - digestive tract development - - - - - The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. - GOC:go_curators - - - - - gut development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. - embryonic organogenesis - biological_process - GO:0048568 - embryonic organ development - - - - - Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. - biological_process - GO:0048570 - notochord morphogenesis - - - - - The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. - biological_process - GO:0048580 - regulation of post-embryonic development - - - - - Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. - down regulation of post-embryonic development - down-regulation of post-embryonic development - downregulation of post-embryonic development - inhibition of post-embryonic development - biological_process - GO:0048581 - negative regulation of post-embryonic development - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. - up regulation of post-embryonic development - up-regulation of post-embryonic development - upregulation of post-embryonic development - activation of post-embryonic development - stimulation of post-embryonic development - biological_process - GO:0048582 - positive regulation of post-embryonic development - - - - - Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. - biological_process - GO:0048583 - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - regulation of response to stimulus - - - - - Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. - up regulation of response to stimulus - up-regulation of response to stimulus - upregulation of response to stimulus - activation of response to stimulus - stimulation of response to stimulus - biological_process - GO:0048584 - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - positive regulation of response to stimulus - - - - - Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. - down regulation of response to stimulus - down-regulation of response to stimulus - downregulation of response to stimulus - inhibition of response to stimulus - biological_process - GO:0048585 - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - negative regulation of response to stimulus - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. - GOC:jid - - - - - - - - - - - - - - - - The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. - developmental growth of a unicellular organism - biological_process - GO:0048588 - developmental cell growth - - - - - The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. - GOC:go_curators - GOC:isa_complete - - - - - - - - - - - - - - - - - - - - - - - - - - The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. - biological_process - GO:0048589 - developmental growth - - - - - The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the eye are generated and organized. - GO:0048748 - biological_process - GO:0048592 - eye morphogenesis - - - - - The process in which the anatomical structures of the eye are generated and organized. - GOC:jid - GOC:mtg_sensu - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. - GO:0048594 - GO:0048595 - camera-style eye morphogenesis - biological_process - GO:0048593 - camera-type eye morphogenesis - - - - - The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. - GOC:jid - GOC:mtg_sensu - - - - - camera-style eye morphogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the eye are generated and organized during embryonic development. - embryonic eye morphogenesis - biological_process - GO:0048596 - embryonic camera-type eye morphogenesis - - - - - The process in which the anatomical structures of the eye are generated and organized during embryonic development. - GOC:jid - GOC:mtg_sensu - - - - - - - - - - - - - - - The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. - GO:0048828 - embryonic anatomical structure morphogenesis - biological_process - GO:0048598 - embryonic morphogenesis - - - - - The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. - GOC:jid - GOC:mtg_sensu - - - - - embryonic anatomical structure morphogenesis - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. - biological_process - GO:0048599 - oocyte development - - - - - The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte. - oocyte morphogenesis during differentiation - biological_process - GO:0048601 - oocyte morphogenesis - - - - - The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte. - GOC:go_curators - - - - - - - - - - - - - - - - The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. - https://github.com/geneontology/go-ontology/issues/23445 - biological_process - GO:0048608 - reproductive structure development - - - - - The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. - GOC:dph - GOC:isa_complete - GOC:jid - - - - - - - - - - - - - - - The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. - organismal reproductive process - reproductive process in a multicellular organism - biological_process - GO:0048609 - multicellular organismal reproductive process - - - - - The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. - GOC:dph - GOC:jid - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. - biological_process - GO:0048627 - myoblast development - - - - - The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. - CL:0000056 - GOC:dph - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. - biological_process - GO:0048628 - myoblast maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. - CL:0000056 - GOC:dph - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size. - biological_process - GO:0048630 - skeletal muscle tissue growth - - - - - The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size. - GOC:lm - PMID:15726494 - PMID:15907921 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle growth. - biological_process - GO:0048631 - regulation of skeletal muscle tissue growth - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle growth. - GOC:lm - PMID:15726494 - PMID:15907921 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth. - down regulation of skeletal muscle growth - down-regulation of skeletal muscle growth - downregulation of skeletal muscle growth - inhibition of skeletal muscle growth - biological_process - GO:0048632 - negative regulation of skeletal muscle tissue growth - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth. - GOC:lm - PMID:15726494 - PMID:15907921 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the rate of skeletal muscle growth. - up regulation of skeletal muscle growth - up-regulation of skeletal muscle growth - upregulation of skeletal muscle growth - activation of skeletal muscle growth - stimulation of skeletal muscle growth - biological_process - GO:0048633 - positive regulation of skeletal muscle tissue growth - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates, maintains or increases the rate of skeletal muscle growth. - GOC:lm - PMID:15726494 - PMID:15907921 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of muscle development. - biological_process - GO:0048634 - regulation of muscle organ development - - - - - Any process that modulates the frequency, rate or extent of muscle development. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. - down regulation of muscle development - down-regulation of muscle development - downregulation of muscle development - inhibition of muscle development - biological_process - GO:0048635 - negative regulation of muscle organ development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the rate of muscle development. - up regulation of muscle development - up-regulation of muscle development - upregulation of muscle development - activation of muscle development - stimulation of muscle development - biological_process - GO:0048636 - positive regulation of muscle organ development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates, maintains or increases the rate of muscle development. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of developmental growth. - biological_process - GO:0048638 - regulation of developmental growth - - - - - Any process that modulates the frequency, rate or extent of developmental growth. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the rate of developmental growth. - up regulation of developmental growth - up-regulation of developmental growth - upregulation of developmental growth - activation of developmental growth - stimulation of developmental growth - biological_process - GO:0048639 - positive regulation of developmental growth - - - - - Any process that activates, maintains or increases the rate of developmental growth. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. - down regulation of developmental growth - down-regulation of developmental growth - downregulation of developmental growth - inhibition of developmental growth - biological_process - GO:0048640 - negative regulation of developmental growth - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle tissue development. - biological_process - GO:0048641 - regulation of skeletal muscle tissue development - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle tissue development. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development. - down regulation of skeletal muscle development - down-regulation of skeletal muscle development - downregulation of skeletal muscle development - inhibition of skeletal muscle development - biological_process - GO:0048642 - negative regulation of skeletal muscle tissue development - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the rate of skeletal muscle tissue development. - up regulation of skeletal muscle development - up-regulation of skeletal muscle development - upregulation of skeletal muscle development - activation of skeletal muscle development - stimulation of skeletal muscle development - biological_process - GO:0048643 - positive regulation of skeletal muscle tissue development - - - - - Any process that activates, maintains or increases the rate of skeletal muscle tissue development. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of muscle are generated and organized. - biological_process - GO:0048644 - muscle organ morphogenesis - - - - - The process in which the anatomical structures of muscle are generated and organized. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. - animal organ primordium initiation - initiation of an animal organ primordium - biological_process - GO:0048645 - animal organ formation - - - - - The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. - GOC:dph - GOC:jid - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. - formation of an anatomical structure involved in morphogenesis - biological_process - GO:0048646 - - Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. - anatomical structure formation involved in morphogenesis - - - - - The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. - GOC:dph - GOC:jid - GOC:tb - - - - - formation of an anatomical structure involved in morphogenesis - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population. - SMC proliferation - biological_process - GO:0048659 - smooth muscle cell proliferation - - - - - The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population. - CL:0000192 - GOC:ebc - PMID:1840698 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. - regulation of SMC proliferation - biological_process - GO:0048660 - regulation of smooth muscle cell proliferation - - - - - Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. - CL:0000192 - GOC:ebc - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the rate or extent of smooth muscle cell proliferation. - positive regulation of SMC proliferation - up regulation of smooth muscle cell proliferation - up-regulation of smooth muscle cell proliferation - upregulation of smooth muscle cell proliferation - activation of smooth muscle cell proliferation - stimulation of smooth muscle cell proliferation - biological_process - GO:0048661 - positive regulation of smooth muscle cell proliferation - - - - - Any process that activates or increases the rate or extent of smooth muscle cell proliferation. - CL:0000192 - GOC:ebc - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. - down regulation of smooth muscle cell proliferation - down-regulation of smooth muscle cell proliferation - downregulation of smooth muscle cell proliferation - negative regulation of SMC proliferation - inhibition of smooth muscle cell proliferation - biological_process - GO:0048662 - negative regulation of smooth muscle cell proliferation - - - - - Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. - CL:0000192 - GOC:ebc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. - biological_process - GO:0048666 - neuron development - - - - - The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. - neuron morphogenesis involved in differentiation - biological_process - GO:0048667 - cell morphogenesis involved in neuron differentiation - - - - - The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. - GOC:dph - GOC:tb - - - - - neuron morphogenesis involved in differentiation - GOC:dph - GOC:tb - - - - - - - - - The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. - neuron generation - biological_process - GO:0048699 - generation of neurons - - - - - The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. - GOC:nln - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the skeleton are generated and organized. - skeletal morphogenesis - biological_process - GO:0048705 - skeletal system morphogenesis - - - - - The process in which the anatomical structures of the skeleton are generated and organized. - GOC:dph - GOC:dsf - GOC:jid - GOC:tb - - - - - skeletal morphogenesis - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of a tissue are generated and organized. - biological_process - GO:0048729 - tissue morphogenesis - - - - - The process in which the anatomical structures of a tissue are generated and organized. - GOC:dph - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. - biological_process - hypodermis morphogenesis - GO:0048730 - epidermis morphogenesis - - - - - The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. - GOC:jid - UBERON:0001003 - - - - - hypodermis morphogenesis - GOC:kmv - GOC:rk - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. - biological_process - GO:0048731 - - system development - - - - - The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. - GOC:dph - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. - biological_process - GO:0048732 - gland development - - - - - The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. - biological_process - GO:0048736 - appendage development - - - - - The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. - GOC:jid - GOC:rc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. - heart muscle development - biological_process - GO:0048738 - cardiac muscle tissue development - - - - - The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. - GOC:dph - GOC:jid - GOC:lm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. - skeletal muscle fibre development - skeletal myofiber development - skeletal myofibre development - biological_process - GO:0048741 - skeletal muscle fiber development - - - - - The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. - GOC:dph - GOC:ef - GOC:jid - GOC:lm - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. - regulation of skeletal muscle fibre development - regulation of skeletal myofiber development - regulation of skeletal myofibre development - biological_process - GO:0048742 - regulation of skeletal muscle fiber development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. - GOC:dph - GOC:jid - GOC:mtg_muscle - GOC:sm - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. - positive regulation of skeletal muscle fibre development - positive regulation of skeletal myofiber development - positive regulation of skeletal myofibre development - up regulation of skeletal muscle fiber development - up-regulation of skeletal muscle fiber development - upregulation of skeletal muscle fiber development - activation of skeletal muscle fiber development - stimulation of skeletal muscle fiber development - biological_process - GO:0048743 - positive regulation of skeletal muscle fiber development - - - - - Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. - GOC:dph - GOC:jid - GOC:lm - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. - down regulation of skeletal muscle fiber development - down-regulation of skeletal muscle fiber development - downregulation of skeletal muscle fiber development - negative regulation of skeletal muscle fibre development - negative regulation of skeletal myofiber development - negative regulation of skeletal myofibre development - inhibition of skeletal muscle fiber development - biological_process - GO:0048744 - negative regulation of skeletal muscle fiber development - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. - GOC:dph - GOC:jid - GOC:lm - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. - biological_process - GO:0048745 - smooth muscle tissue development - - - - - The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. - GOC:dph - GOC:jid - GOC:lm - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye. - GO:0007456 - insect-type retina development - biological_process - GO:0048749 - compound eye development - - - - - The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye. - GOC:jid - GOC:mtg_sensu - Wikipedia:Eye - - - - - insect-type retina development - PMID:11735386 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. - pigment granule organisation - biological_process - pigment granule organization and biogenesis - GO:0048753 - - pigment granule organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. - GOC:rc - - - - - pigment granule organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. - biological_process - tubulogenesis - GO:0048754 - branching morphogenesis of an epithelial tube - - - - - The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. - GOC:dgh - GOC:dph - GOC:jid - - - - - tubulogenesis - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron). - biological_process - GO:0048755 - branching morphogenesis of a nerve - - - - - The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron). - GOC:dgh - GOC:dph - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. - biological_process - GO:0048762 - mesenchymal cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. - GOC:dph - GOC:jid - - - - - - - - - A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. - cellular_component - GO:0048770 - pigment granule - - - - - A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. - GOC:jid - GOC:mh - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. - biological_process - GO:0048799 - animal organ maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. - GOC:curators - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. - genital development - biological_process - GO:0048806 - genitalia development - - - - - The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. - neurite biosynthesis - neurite formation - neurite growth - biological_process - neurite morphogenesis - GO:0048812 - neuron projection morphogenesis - - - - - The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. - GOC:mah - - - - - neurite morphogenesis - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. - RBC development - red blood cell development - biological_process - GO:0048821 - erythrocyte development - - - - - The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. - GOC:devbiol - - - - - RBC development - CL:0000232 - - - - - red blood cell development - CL:0000232 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. - enucleate RBC development - enucleate red blood cell development - biological_process - GO:0048822 - enucleate erythrocyte development - - - - - The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. - GOC:devbiol - - - - - enucleate RBC development - CL:0000232 - - - - - enucleate red blood cell development - CL:0000232 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. - nucleate RBC development - nucleate red blood cell development - biological_process - GO:0048823 - nucleate erythrocyte development - - - - - The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. - GOC:devbiol - - - - - nucleate RBC development - CL:0000232 - - - - - nucleate red blood cell development - CL:0000232 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. - arterial morphogenesis - arteriogenesis - biological_process - GO:0048844 - artery morphogenesis - - - - - The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. - GOC:dsf - PMID:16740480 - - - - - arteriogenesis - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart. - vein morphogenesis - venous morphogenesis - biological_process - GO:0048845 - venous blood vessel morphogenesis - - - - - The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart. - GOC:dsf - PMID:16740480 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). - biological_process - GO:0048854 - brain morphogenesis - - - - - The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). - GOC:dgh - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. - development of an anatomical structure - biological_process - GO:0048856 - - - - anatomical structure development - - - - - The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. - biological_process - GO:0048857 - neural nucleus development - - - - - The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of a cell projection are generated and organized. - biological_process - GO:0048858 - cell projection morphogenesis - - - - - The process in which the anatomical structures of a cell projection are generated and organized. - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. - biological_process - GO:0048859 - formation of anatomical boundary - - - - - The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. - GO_REF:0000021 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. - - Wikipedia:Stem_cell_differentiation - biological_process - GO:0048863 - stem cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. - CL:0000034 - GOC:isa_complete - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate. - biological_process - GO:0048864 - stem cell development - - - - - The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate. - CL:0000034 - GOC:isa_complete - - - - - - - - - - A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. - biological_process - GO:0048869 - cellular developmental process - - - - - A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. - GOC:isa_complete - - - - - - - - - Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. - https://github.com/geneontology/go-ontology/issues/19809 - cell locomotion - movement of a cell - biological_process - cell movement - GO:0048870 - - - - - cell motility - - - - - Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. - GOC:dgh - GOC:dph - GOC:isa_complete - GOC:mlg - - - - - - - - - - Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. - biological_process - GO:0048871 - multicellular organismal-level homeostasis - - - - - Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. - GOC:isa_complete - - - - - - - - - Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. - https://github.com/geneontology/go-ontology/issues/24218 - cell population homeostasis - homeostasis of cell number - biological_process - GO:0048872 - homeostasis of number of cells - - - - - Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. - GOC:isa_complete - - - - - homeostasis of cell number - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure. - biological_process - GO:0048880 - sensory system development - - - - - The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure. - GOC:dgh - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. - biological_process - GO:0048934 - peripheral nervous system neuron differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. - GOC:dgh - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. - biological_process - GO:0048935 - peripheral nervous system neuron development - - - - - The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. - GOC:dgh - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a chromosome is transported to, or maintained in, a specific location. - chromosome localisation - establishment and maintenance of chromosome localization - establishment and maintenance of chromosome position - biological_process - GO:0050000 - chromosome localization - - - - - Any process in which a chromosome is transported to, or maintained in, a specific location. - GOC:ai - - - - - chromosome localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. - biological_process - GO:0050432 - catecholamine secretion - - - - - The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. - GOC:ai - GOC:ef - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. - biological_process - GO:0050433 - regulation of catecholamine secretion - - - - - Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0050657 - nucleic acid transport - - - - - The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0050658 - RNA transport - - - - - The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. - biological_process - GO:0050673 - epithelial cell proliferation - - - - - The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. - ISBN:0721662544 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of epithelial cell proliferation. - biological_process - GO:0050678 - regulation of epithelial cell proliferation - - - - - Any process that modulates the frequency, rate or extent of epithelial cell proliferation. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the rate or extent of epithelial cell proliferation. - up regulation of epithelial cell proliferation - up-regulation of epithelial cell proliferation - upregulation of epithelial cell proliferation - activation of epithelial cell proliferation - stimulation of epithelial cell proliferation - biological_process - GO:0050679 - positive regulation of epithelial cell proliferation - - - - - Any process that activates or increases the rate or extent of epithelial cell proliferation. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. - down regulation of epithelial cell proliferation - down-regulation of epithelial cell proliferation - downregulation of epithelial cell proliferation - inhibition of epithelial cell proliferation - biological_process - GO:0050680 - negative regulation of epithelial cell proliferation - - - - - Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. - biological_process - GO:0050708 - regulation of protein secretion - - - - - Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. - down regulation of protein secretion - down-regulation of protein secretion - downregulation of protein secretion - inhibition of protein secretion - biological_process - GO:0050709 - negative regulation of protein secretion - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. - up regulation of protein secretion - up-regulation of protein secretion - upregulation of protein secretion - activation of protein secretion - stimulation of protein secretion - biological_process - GO:0050714 - positive regulation of protein secretion - - - - - Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. - biological_process - GO:0050767 - regulation of neurogenesis - - - - - Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. - down regulation of neurogenesis - down-regulation of neurogenesis - downregulation of neurogenesis - inhibition of neurogenesis - biological_process - GO:0050768 - negative regulation of neurogenesis - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. - up regulation of neurogenesis - up-regulation of neurogenesis - upregulation of neurogenesis - activation of neurogenesis - stimulation of neurogenesis - biological_process - GO:0050769 - positive regulation of neurogenesis - - - - - Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. - biological_process - GO:0050776 - regulation of immune response - - - - - Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. - down regulation of immune response - down-regulation of immune response - downregulation of immune response - inhibition of immune response - biological_process - GO:0050777 - negative regulation of immune response - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. - up regulation of immune response - up-regulation of immune response - upregulation of immune response - stimulation of immune response - biological_process - GO:0050778 - positive regulation of immune response - - - - - Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - GO:0050791 - regulation of physiological process - biological_process - GO:0050789 - - - - regulation of biological process - - - - - Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. - GOC:ai - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the activity of an enzyme. - GO:0048552 - regulation of enzyme activity - regulation of metalloenzyme activity - biological_process - GO:0050790 - - - regulation of catalytic activity - - - - - Any process that modulates the activity of an enzyme. - GOC:ai - GOC:ebc - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). - biological_process - GO:0050793 - regulation of developmental process - - - - - Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GO:0051244 - regulation of cellular physiological process - biological_process - GO:0050794 - - regulation of cellular process - - - - - Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. - regulation of behaviour - biological_process - GO:0050795 - regulation of behavior - - - - - Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. - GOC:go_curators - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the regulated release of insulin. - biological_process - GO:0050796 - regulation of insulin secretion - - - - - Any process that modulates the frequency, rate or extent of the regulated release of insulin. - GOC:ai - - - - - - - - - - - - - - - - - - - - Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). - biological_process - GO:0050803 - regulation of synapse structure or activity - - - - - Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. - modulation of synaptic transmission - regulation of chemical synaptic transmission - regulation of synaptic transmission - biological_process - GO:0050804 - - modulation of chemical synaptic transmission - - - - - Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. - down regulation of synaptic transmission - down-regulation of synaptic transmission - downregulation of synaptic transmission - inhibition of synaptic transmission - biological_process - GO:0050805 - negative regulation of synaptic transmission - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. - up regulation of synaptic transmission - up-regulation of synaptic transmission - upregulation of synaptic transmission - activation of synaptic transmission - stimulation of synaptic transmission - biological_process - GO:0050806 - positive regulation of synaptic transmission - - - - - Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). - regulation of synapse organisation - regulation of synapse structure - biological_process - regulation of synapse organization and biogenesis - GO:0050807 - - regulation of synapse organization - - - - - Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). - GOC:ai - GOC:dph - GOC:tb - - - - - regulation of synapse organisation - GOC:mah - - - - - regulation of synapse organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). - synapse organisation - biological_process - synapse development - synapse morphogenesis - synapse organization and biogenesis - GO:0050808 - - - synapse organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). - GOC:ai - GOC:pr - - - - - synapse development - GOC:aruk - - - - - synapse morphogenesis - GOC:BHF - - - - - synapse organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. - regulation of steroid anabolism - regulation of steroid biosynthesis - regulation of steroid formation - regulation of steroid synthesis - regulation of steroidogenesis - biological_process - GO:0050810 - regulation of steroid biosynthetic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A organ system process carried out by any of the organs or tissues of neurological system. - https://github.com/geneontology/go-ontology/issues/13824 - neurological system process - neurophysiological process - biological_process - pan-neural process - GO:0050877 - - - - - - nervous system process - - - - - A organ system process carried out by any of the organs or tissues of neurological system. - GOC:ai - GOC:mtg_cardio - - - - - - - - - Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. - biological_process - GO:0050879 - - multicellular organismal movement - - - - - Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. - GOC:dph - GOC:mtg_muscle - GOC:tb - - - - - - - - - - The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. - biological_process - GO:0050881 - musculoskeletal movement - - - - - The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. - GOC:dph - - - - - - - - - The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. - endocrine physiological process - endocrine physiology - biological_process - GO:0050886 - - - endocrine process - - - - - The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. - ISBN:0721662544 - - - - - - - - - The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. - Wikipedia:Cognition - biological_process - GO:0050890 - - cognition - - - - - The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. - ISBN:0721619908 - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. - GO:0051869 - physiological response to stimulus - biological_process - GO:0050896 - - - - - - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - response to stimulus - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. - GOC:ai - GOC:bf - - - - - - - - - Any process pertaining to the functions of the nervous and muscular systems of an organism. - neuromotor process - neuromuscular physiological process - biological_process - GO:0050905 - neuromuscular process - - - - - Any process pertaining to the functions of the nervous and muscular systems of an organism. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal. - Wikipedia:Transduction_(physiology) - sensory detection of stimulus - sensory perception, sensory transduction of stimulus - sensory perception, stimulus detection - sensory transduction - biological_process - GO:0050906 - detection of stimulus involved in sensory perception - - - - - The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal. - GOC:ai - GOC:dos - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception. - sensory detection of chemical stimulus - sensory detection of chemical stimulus during sensory perception - sensory perception, sensory detection of chemical stimulus - sensory perception, sensory transduction of chemical stimulus - sensory transduction of chemical stimulus - sensory transduction of chemical stimulus during sensory perception - biological_process - GO:0050907 - detection of chemical stimulus involved in sensory perception - - - - - The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception. - GOC:ai - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. - sensory detection of light during visual perception - sensory detection of light stimulus during visual perception - sensory transduction of light during visual perception - sensory transduction of light stimulus during visual perception - visual perception, detection of light stimulus - visual perception, sensory transduction during perception of light - visual perception, sensory transduction of light stimulus - biological_process - GO:0050908 - detection of light stimulus involved in visual perception - - - - - The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. - GOC:ai - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. - GO:0043357 - GO:0043358 - chromatophore differentiation - pigmented cell differentiation - biological_process - GO:0050931 - Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore. - pigment cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. - GOC:dgh - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of pigmented cell differentiation. - biological_process - GO:0050932 - regulation of pigment cell differentiation - - - - - Any process that modulates the frequency, rate or extent of pigmented cell differentiation. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation. - down regulation of pigment cell differentiation - down-regulation of pigment cell differentiation - downregulation of pigment cell differentiation - inhibition of pigment cell differentiation - biological_process - GO:0050941 - negative regulation of pigment cell differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of pigment cell differentiation. - up regulation of pigment cell differentiation - up-regulation of pigment cell differentiation - upregulation of pigment cell differentiation - activation of pigment cell differentiation - stimulation of pigment cell differentiation - biological_process - GO:0050942 - positive regulation of pigment cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of pigment cell differentiation. - GOC:ai - - - - - - - - - The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. - biological_process - GO:0050952 - sensory perception of electrical stimulus - - - - - The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. - GOC:ai - - - - - - - - - The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. - biological_process - GO:0050953 - sensory perception of light stimulus - - - - - The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. - GOC:ai - - - - - - - - - The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. - mechanosensory perception - perception of mechanical stimulus - biological_process - chemi-mechanical coupling - GO:0050954 - sensory perception of mechanical stimulus - - - - - The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. - GOC:ai - - - - - - - - - The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location. - Wikipedia:Electroreception - electroception sense - electroceptive sense - biological_process - GO:0050956 - electroception - - - - - The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location. - GOC:ai - PMID:10210663 - Wikipedia:Electroreception - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. - sensory detection of light stimulus - sensory detection of light stimulus during sensory perception - sensory perception, sensory detection of light stimulus - sensory perception, sensory transduction of light stimulus - sensory transduction of light stimulus - sensory transduction of light stimulus during sensory perception - biological_process - GO:0050962 - detection of light stimulus involved in sensory perception - - - - - The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. - GOC:ai - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception. - sensory detection of electrical stimulus - sensory detection of electrical stimulus during sensory perception - sensory perception, sensory detection of electrical stimulus - sensory perception, sensory transduction of electrical stimulus - sensory transduction of electrical stimulus - sensory transduction of electrical stimulus during sensory perception - biological_process - GO:0050963 - detection of electrical stimulus involved in sensory perception - - - - - The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception. - GOC:ai - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal. - electroception, detection of electrical stimulus - electroception, sensory detection of electrical stimulus - electroception, sensory transduction - electroception, sensory transduction of electrical stimulus - biological_process - detection of electrical stimulus during electroreception - sensory detection of electrical stimulus during electroception - sensory transduction of electrical stimulus during electroception - GO:0050964 - detection of electrical stimulus involved in electroception - - - - - The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal. - GOC:ai - GOC:dos - - - - - detection of electrical stimulus during electroreception - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal. - perception of pain, detection of electrical stimulus - perception of pain, sensory detection of electrical stimulus - perception of pain, sensory transduction of electrical stimulus - biological_process - detection of electrical stimulus during sensory perception of pain - sensory detection of electrical stimulus during perception of pain - sensory transduction of electrical stimulus during perception of pain - GO:0050967 - detection of electrical stimulus involved in sensory perception of pain - - - - - The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal. - GOC:ai - GOC:dos - GOC:dph - GOC:tb - - - - - detection of electrical stimulus during sensory perception of pain - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal. - perception of pain, detection of chemical stimulus - perception of pain, sensory detection of chemical stimulus - perception of pain, sensory transduction of chemical stimulus - sensory detection of chemical stimulus during perception of pain - sensory transduction of chemical stimulus during perception of pain - biological_process - chemical nociception - GO:0050968 - detection of chemical stimulus involved in sensory perception of pain - - - - - The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal. - GOC:ai - - - - - chemical nociception - GOC:pr - - - - - - - - - The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). - Wikipedia:Touch - perception of touch - tactile sense - taction - tactition - biological_process - GO:0050975 - sensory perception of touch - - - - - The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). - GOC:ai - - - - - - - - - - The series of events by which an electrical stimulus is received and converted into a molecular signal. - biological_process - GO:0050981 - detection of electrical stimulus - - - - - The series of events by which an electrical stimulus is received and converted into a molecular signal. - GOC:ai - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. - regulation of lipid breakdown - regulation of lipid catabolism - regulation of lipid degradation - biological_process - GO:0050994 - regulation of lipid catabolic process - - - - - Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. - down regulation of lipid catabolic process - down-regulation of lipid catabolic process - downregulation of lipid catabolic process - negative regulation of lipid breakdown - negative regulation of lipid catabolism - negative regulation of lipid degradation - inhibition of lipid catabolic process - biological_process - GO:0050995 - negative regulation of lipid catabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. - positive regulation of lipid breakdown - positive regulation of lipid catabolism - positive regulation of lipid degradation - up regulation of lipid catabolic process - up-regulation of lipid catabolic process - upregulation of lipid catabolic process - activation of lipid catabolic process - stimulation of lipid catabolic process - biological_process - GO:0050996 - positive regulation of lipid catabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. - GO:0045011 - biological_process - actin bundling activity - actin cable assembly - actin cable formation - GO:0051017 - actin filament bundle assembly - - - - - The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. - GOC:ai - - - - - actin cable assembly - GOC:mah - - - - - actin cable formation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0051027 - DNA transport - - - - - The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information. - molecular_function - GO:0051032 - nucleic acid transmembrane transporter activity - - - - - Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other. - Reactome:R-HSA-203906 - molecular_function - GO:0051033 - RNA transmembrane transporter activity - - - - - Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other. - GOC:ai - - - - - Reactome:R-HSA-203906 - Exportin complex translocates pre-miRNA to cytosol - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other. - molecular_function - GO:0051035 - DNA transmembrane transporter activity - - - - - Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. - biological_process - GO:0051046 - regulation of secretion - - - - - Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. - up regulation of secretion - up-regulation of secretion - upregulation of secretion - activation of secretion - stimulation of secretion - biological_process - GO:0051047 - positive regulation of secretion - - - - - Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. - down regulation of secretion - down-regulation of secretion - downregulation of secretion - inhibition of secretion - biological_process - GO:0051048 - negative regulation of secretion - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0051049 - - regulation of transport - - - - - Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - up regulation of transport - up-regulation of transport - upregulation of transport - activation of transport - stimulation of transport - biological_process - GO:0051050 - positive regulation of transport - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - down regulation of transport - down-regulation of transport - downregulation of transport - inhibition of transport - biological_process - GO:0051051 - negative regulation of transport - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. - regulation of DNA metabolism - biological_process - GO:0051052 - - regulation of DNA metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. - down regulation of DNA metabolic process - down-regulation of DNA metabolic process - downregulation of DNA metabolic process - negative regulation of DNA metabolism - inhibition of DNA metabolic process - biological_process - GO:0051053 - negative regulation of DNA metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. - positive regulation of DNA metabolism - up regulation of DNA metabolic process - up-regulation of DNA metabolic process - upregulation of DNA metabolic process - activation of DNA metabolic process - stimulation of DNA metabolic process - biological_process - GO:0051054 - positive regulation of DNA metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. - down regulation of lipid biosynthetic process - down-regulation of lipid biosynthetic process - downregulation of lipid biosynthetic process - negative regulation of lipid anabolism - negative regulation of lipid biosynthesis - negative regulation of lipid formation - negative regulation of lipid synthesis - negative regulation of lipogenesis - inhibition of lipid biosynthetic process - biological_process - GO:0051055 - negative regulation of lipid biosynthetic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. - GOC:ai - - - - - negative regulation of lipogenesis - GOC:sl - - - - - - - - - - - - - - - - - - - - - - - - - - - The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs. - biological_process - meiotic nuclear envelope breakdown - meiotic nuclear envelope catabolism - meiotic nuclear envelope degradation - meiotic nuclear envelope disassembly - GO:0051078 - meiotic nuclear membrane disassembly - - - - - The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs. - GOC:bf - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The controlled breakdown of the nuclear membranes, for example during cellular division. - biological_process - nuclear envelope breakdown - nuclear envelope catabolism - nuclear envelope degradation - nuclear envelope disassembly - GO:0051081 - nuclear membrane disassembly - - - - - The controlled breakdown of the nuclear membranes, for example during cellular division. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). - down regulation of developmental process - down-regulation of developmental process - downregulation of developmental process - inhibition of developmental process - biological_process - GO:0051093 - negative regulation of developmental process - - - - - Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). - up regulation of developmental process - up-regulation of developmental process - upregulation of developmental process - activation of developmental process - stimulation of developmental process - biological_process - GO:0051094 - positive regulation of developmental process - - - - - Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). - GOC:ai - - - - - - - - - Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. - Reactome:R-HSA-428779 - Reactome:R-HSA-8875902 - Reactome:R-HSA-8876319 - sugar/polyol channel activity - molecular_function - GO:0051119 - sugar transmembrane transporter activity - - - - - Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. - GOC:ai - GOC:mtg_transport - ISBN:0815340729 - - - - - Reactome:R-HSA-428779 - GLUT7 and GLUT11 transport glucose and fructose - - - - - Reactome:R-HSA-8875902 - SLC45A3 transports Glc from extracellular region to cytosol - - - - - Reactome:R-HSA-8876319 - SLC50A1 transports Glc from cytosol to extracellular region - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. - regulation of cellular component organisation - biological_process - regulation of cell organisation - regulation of cell organization - regulation of cellular component organization and biogenesis - GO:0051128 - regulation of cellular component organization - - - - - Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. - GOC:ai - - - - - regulation of cell organisation - GOC:mah - - - - - regulation of cell organization - GOC:mah - - - - - regulation of cellular component organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. - down regulation of cell organization - down-regulation of cell organization - downregulation of cell organization - inhibition of cell organization - biological_process - negative regulation of cell organisation - negative regulation of cellular component organization and biogenesis - GO:0051129 - negative regulation of cellular component organization - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. - GOC:ai - - - - - negative regulation of cell organisation - GOC:mah - - - - - negative regulation of cellular component organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. - positive regulation of cell organisation - up regulation of cell organization - up-regulation of cell organization - upregulation of cell organization - activation of cell organization - stimulation of cell organization - biological_process - positive regulation of cellular component organization and biogenesis - GO:0051130 - positive regulation of cellular component organization - - - - - Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. - GOC:ai - - - - - positive regulation of cellular component organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. - nonstriated muscle cell differentiation - biological_process - GO:0051145 - smooth muscle cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. - CL:0000192 - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. - voluntary muscle cell differentiation - biological_process - GO:0051146 - striated muscle cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. - CL:0000737 - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of muscle cell differentiation. - biological_process - GO:0051147 - regulation of muscle cell differentiation - - - - - Any process that modulates the frequency, rate or extent of muscle cell differentiation. - CL:0000187 - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. - down regulation of muscle cell differentiation - down-regulation of muscle cell differentiation - downregulation of muscle cell differentiation - inhibition of muscle cell differentiation - biological_process - GO:0051148 - negative regulation of muscle cell differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. - CL:0000187 - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. - up regulation of muscle cell differentiation - up-regulation of muscle cell differentiation - upregulation of muscle cell differentiation - activation of muscle cell differentiation - stimulation of muscle cell differentiation - biological_process - GO:0051149 - positive regulation of muscle cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. - CL:0000187 - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. - biological_process - GO:0051150 - regulation of smooth muscle cell differentiation - - - - - Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. - CL:0000192 - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation. - down regulation of smooth muscle cell differentiation - down-regulation of smooth muscle cell differentiation - downregulation of smooth muscle cell differentiation - inhibition of smooth muscle cell differentiation - biological_process - GO:0051151 - negative regulation of smooth muscle cell differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation. - CL:0000192 - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation. - up regulation of smooth muscle cell differentiation - up-regulation of smooth muscle cell differentiation - upregulation of smooth muscle cell differentiation - activation of smooth muscle cell differentiation - stimulation of smooth muscle cell differentiation - biological_process - GO:0051152 - positive regulation of smooth muscle cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation. - CL:0000192 - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. - biological_process - GO:0051153 - regulation of striated muscle cell differentiation - - - - - Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. - CL:0000737 - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. - down regulation of striated muscle cell differentiation - down-regulation of striated muscle cell differentiation - downregulation of striated muscle cell differentiation - inhibition of striated muscle cell differentiation - biological_process - GO:0051154 - negative regulation of striated muscle cell differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. - CL:0000737 - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. - up regulation of striated muscle cell differentiation - up-regulation of striated muscle cell differentiation - upregulation of striated muscle cell differentiation - activation of striated muscle cell differentiation - stimulation of striated muscle cell differentiation - biological_process - GO:0051155 - positive regulation of striated muscle cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. - CL:0000737 - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of substances into, out of, or within the nucleus. - Wikipedia:Nuclear_transport - nucleus transport - biological_process - GO:0051169 - - nuclear transport - - - - - The directed movement of substances into, out of, or within the nucleus. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. - regulation of nitrogen metabolic process - regulation of nitrogen metabolism - biological_process - GO:0051171 - regulation of nitrogen compound metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. - GOC:ai - GOC:tb - - - - - regulation of nitrogen metabolic process - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. - down regulation of nitrogen metabolic process - down-regulation of nitrogen metabolic process - downregulation of nitrogen metabolic process - negative regulation of nitrogen metabolic process - negative regulation of nitrogen metabolism - inhibition of nitrogen metabolic process - biological_process - GO:0051172 - negative regulation of nitrogen compound metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. - GOC:ai - GOC:tb - - - - - negative regulation of nitrogen metabolic process - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. - positive regulation of nitrogen metabolic process - positive regulation of nitrogen metabolism - up regulation of nitrogen metabolic process - up-regulation of nitrogen metabolic process - upregulation of nitrogen metabolic process - activation of nitrogen metabolic process - stimulation of nitrogen metabolic process - biological_process - GO:0051173 - positive regulation of nitrogen compound metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. - GOC:ai - GOC:tb - - - - - positive regulation of nitrogen metabolic process - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. - regulation of phosphorus metabolism - biological_process - GO:0051174 - regulation of phosphorus metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur. - down regulation of sulfur metabolic process - down-regulation of sulfur metabolic process - downregulation of sulfur metabolic process - negative regulation of sulfur metabolism - negative regulation of sulphur metabolic process - negative regulation of sulphur metabolism - inhibition of sulfur metabolic process - biological_process - GO:0051175 - negative regulation of sulfur metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur. - positive regulation of sulfur metabolism - positive regulation of sulphur metabolic process - positive regulation of sulphur metabolism - up regulation of sulfur metabolic process - up-regulation of sulfur metabolic process - upregulation of sulfur metabolic process - activation of sulfur metabolic process - stimulation of sulfur metabolic process - biological_process - GO:0051176 - positive regulation of sulfur metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur. - GOC:ai - - - - - - - - - Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. - jl - 2013-12-18T13:51:04Z - GO:1902578 - establishment and maintenance of localization - establishment and maintenance of position - localisation - establishment and maintenance of cellular component location - establishment and maintenance of substance location - establishment and maintenance of substrate location - biological_process - single organism localization - single-organism localization - GO:0051179 - - localization - - - - - Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. - GOC:ai - GOC:dos - - - - - localisation - GOC:mah - - - - - single organism localization - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. - Wikipedia:Chondrogenesis - cartilage biogenesis - cartilage biosynthesis - cartilage element development - cartilage formation - cartilage organ development - chondrogenesis - biological_process - GO:0051216 - cartilage development - - - - - The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. - GOC:cjm - PMID:23251424 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - up regulation of protein transport - up-regulation of protein transport - upregulation of protein transport - activation of protein transport - stimulation of protein transport - biological_process - GO:0051222 - positive regulation of protein transport - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0051223 - regulation of protein transport - - - - - Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - down regulation of protein transport - down-regulation of protein transport - downregulation of protein transport - inhibition of protein transport - biological_process - GO:0051224 - negative regulation of protein transport - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. - https://github.com/geneontology/go-ontology/issues/24200 - establishment of localisation - biological_process - GO:0051234 - - - - - - establishment of localization - - - - - Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. - GOC:ai - GOC:dos - - - - - establishment of localisation - GOC:mah - - - - - - - - - - - - - - - The directed movement of RNA to a specific location. - RNA positioning - RNA recruitment - establishment of RNA localisation - biological_process - GO:0051236 - establishment of RNA localization - - - - - The directed movement of RNA to a specific location. - GOC:ai - - - - - establishment of RNA localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. - biological_process - GO:0051239 - regulation of multicellular organismal process - - - - - Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. - GOC:ai - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. - up regulation of multicellular organismal process - up-regulation of multicellular organismal process - upregulation of multicellular organismal process - activation of multicellular organismal process - stimulation of multicellular organismal process - biological_process - GO:0051240 - positive regulation of multicellular organismal process - - - - - Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. - down regulation of multicellular organismal process - down-regulation of multicellular organismal process - downregulation of multicellular organismal process - inhibition of multicellular organismal process - biological_process - GO:0051241 - negative regulation of multicellular organismal process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. - https://github.com/geneontology/go-ontology/issues/23112 - GO:0032268 - regulation of protein metabolism - biological_process - regulation of cellular protein metabolic process - regulation of cellular protein metabolism - GO:0051246 - regulation of protein metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. - https://github.com/geneontology/go-ontology/issues/23112 - GO:0032270 - positive regulation of cellular protein metabolic process - positive regulation of cellular protein metabolism - positive regulation of protein metabolism - up regulation of cellular protein metabolic process - up regulation of protein metabolic process - up-regulation of cellular protein metabolic process - up-regulation of protein metabolic process - upregulation of cellular protein metabolic process - upregulation of protein metabolic process - activation of cellular protein metabolic process - activation of protein metabolic process - stimulation of cellular protein metabolic process - stimulation of protein metabolic process - biological_process - GO:0051247 - positive regulation of protein metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. - https://github.com/geneontology/go-ontology/issues/23112 - GO:0032269 - down regulation of cellular protein metabolic process - down regulation of protein metabolic process - down-regulation of cellular protein metabolic process - down-regulation of protein metabolic process - downregulation of cellular protein metabolic process - downregulation of protein metabolic process - negative regulation of cellular protein metabolic process - negative regulation of cellular protein metabolism - negative regulation of protein metabolism - inhibition of cellular protein metabolic process - inhibition of protein metabolic process - biological_process - GO:0051248 - negative regulation of protein metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. - regulation of RNA metabolism - biological_process - GO:0051252 - regulation of RNA metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA. - down regulation of RNA metabolic process - down-regulation of RNA metabolic process - downregulation of RNA metabolic process - negative regulation of RNA metabolism - inhibition of RNA metabolic process - biological_process - GO:0051253 - negative regulation of RNA metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA. - positive regulation of RNA metabolism - up regulation of RNA metabolic process - up-regulation of RNA metabolic process - upregulation of RNA metabolic process - activation of RNA metabolic process - stimulation of RNA metabolic process - biological_process - GO:0051254 - positive regulation of RNA metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA. - GOC:ai - - - - - - - - - The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. - protein polymer biosynthesis - protein polymer biosynthetic process - protein polymer formation - biological_process - GO:0051258 - - protein polymerization - - - - - The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. - GOC:ai - - - - - - - - - The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. - protein polymer breakdown - protein polymer catabolic process - protein polymer catabolism - protein polymer degradation - biological_process - GO:0051261 - - protein depolymerization - - - - - The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. - https://github.com/geneontology/go-ontology/issues/22811 - https://github.com/geneontology/go-ontology/issues/4585 - GO:0006323 - GO:0007001 - GO:0051277 - DNA condensation - chromosome organisation - DNA packaging - biological_process - chromosome organization and biogenesis - maintenance of genome integrity - nuclear genome maintenance - GO:0051276 - - - - chromosome organization - - - - - A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. - GOC:ai - GOC:dph - GOC:jl - GOC:mah - - - - - chromosome organization and biogenesis - GOC:mah - - - - - - - - - The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. - Wikipedia:Cell_division - biological_process - GO:0051301 - - - - Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. - cell division - - - - - The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. - GOC:di - GOC:go_curators - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. - biological_process - GO:0051302 - regulation of cell division - - - - - Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. - GOC:go_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a chromosome to a specific location. - chromosome positioning - establishment of chromosome localisation - biological_process - GO:0051303 - establishment of chromosome localization - - - - - The directed movement of a chromosome to a specific location. - GOC:ai - - - - - establishment of chromosome localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. - https://github.com/geneontology/go-ontology/issues/24599 - GO:0007126 - Wikipedia:Meiosis - biological_process - meiosis - GO:0051321 - - - Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. - meiotic cell cycle - - - - - Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. - hydrolase regulator - biological_process - GO:0051336 - - regulation of hydrolase activity - - - - - Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. - transferase regulator - biological_process - GO:0051338 - - - This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. - regulation of transferase activity - - - - - Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. - hydrolase activator - up regulation of hydrolase activity - up-regulation of hydrolase activity - upregulation of hydrolase activity - activation of hydrolase activity - stimulation of hydrolase activity - biological_process - GO:0051345 - - positive regulation of hydrolase activity - - - - - Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. - down regulation of hydrolase activity - down-regulation of hydrolase activity - downregulation of hydrolase activity - hydrolase inhibitor - inhibition of hydrolase activity - biological_process - GO:0051346 - - negative regulation of hydrolase activity - - - - - Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. - transferase activator - up regulation of transferase activity - up-regulation of transferase activity - upregulation of transferase activity - activation of transferase activity - stimulation of transferase activity - biological_process - GO:0051347 - - - This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. - positive regulation of transferase activity - - - - - Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. - down regulation of transferase activity - down-regulation of transferase activity - downregulation of transferase activity - transferase inhibitor - inhibition of transferase activity - biological_process - GO:0051348 - - - This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. - negative regulation of transferase activity - - - - - Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. - apoptosis of neuronal cells - apoptosis of neurons - neuron programmed cell death by apoptosis - neuronal cell apoptosis - neuronal cell programmed cell death by apoptosis - programmed cell death of neuronal cells by apoptosis - programmed cell death of neurons by apoptosis - programmed cell death, neuronal cells - programmed cell death, neurons - neuron apoptosis - biological_process - GO:0051402 - neuron apoptotic process - - - - - Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. - CL:0000540 - GOC:mtg_apoptosis - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. - detoxification of nitrogenous compound - nitric oxide (NO) detoxification - biological_process - GO:0051410 - detoxification of nitrogen compound - - - - - Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate or extent of progression through the meiotic cell cycle. - meiotic cell cycle modulation - meiotic cell cycle regulation - modulation of meiotic cell cycle progression - regulation of meiotic cell cycle progression - regulation of progression through meiotic cell cycle - biological_process - meiotic cell cycle regulator - GO:0051445 - regulation of meiotic cell cycle - - - - - Any process that modulates the rate or extent of progression through the meiotic cell cycle. - GOC:ai - GOC:dph - GOC:tb - - - - - regulation of progression through meiotic cell cycle - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. - positive regulation of meiotic cell cycle progression - positive regulation of progression through meiotic cell cycle - up regulation of progression through meiotic cell cycle - up-regulation of progression through meiotic cell cycle - upregulation of progression through meiotic cell cycle - activation of progression through meiotic cell cycle - stimulation of progression through meiotic cell cycle - biological_process - GO:0051446 - positive regulation of meiotic cell cycle - - - - - Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. - GOC:ai - GOC:dph - GOC:tb - - - - - positive regulation of progression through meiotic cell cycle - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. - down regulation of progression through meiotic cell cycle - down-regulation of progression through meiotic cell cycle - downregulation of progression through meiotic cell cycle - negative regulation of meiotic cell cycle progression - negative regulation of progression through meiotic cell cycle - inhibition of progression through meiotic cell cycle - biological_process - GO:0051447 - negative regulation of meiotic cell cycle - - - - - Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. - GOC:ai - GOC:dph - GOC:tb - - - - - negative regulation of progression through meiotic cell cycle - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. - biological_process - GO:0051450 - myoblast proliferation - - - - - The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. - CL:0000056 - GOC:ai - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole. - GO:0042146 - biological_process - heterotypic vacuole fusion (non-autophagic) - heterotypic vacuole fusion, non-autophagic - GO:0051469 - vesicle fusion with vacuole - - - - - The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. - regulation of cytoskeleton organisation - biological_process - regulation of cytoskeleton organization and biogenesis - GO:0051493 - regulation of cytoskeleton organization - - - - - Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. - GOC:ai - - - - - regulation of cytoskeleton organisation - GOC:mah - - - - - regulation of cytoskeleton organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. - down regulation of cytoskeleton organization - down-regulation of cytoskeleton organization - downregulation of cytoskeleton organization - negative regulation of cytoskeleton organisation - inhibition of cytoskeleton organization - biological_process - negative regulation of cytoskeleton organization and biogenesis - GO:0051494 - negative regulation of cytoskeleton organization - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. - GOC:ai - - - - - negative regulation of cytoskeleton organisation - GOC:mah - - - - - negative regulation of cytoskeleton organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. - positive regulation of cytoskeleton organisation - up regulation of cytoskeleton organization - up-regulation of cytoskeleton organization - upregulation of cytoskeleton organization - activation of cytoskeleton organization - stimulation of cytoskeleton organization - biological_process - positive regulation of cytoskeleton organization and biogenesis - GO:0051495 - positive regulation of cytoskeleton organization - - - - - Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. - GOC:ai - - - - - positive regulation of cytoskeleton organisation - GOC:mah - - - - - positive regulation of cytoskeleton organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0051588 - regulation of neurotransmitter transport - - - - - Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - down regulation of neurotransmitter transport - down-regulation of neurotransmitter transport - downregulation of neurotransmitter transport - inhibition of neurotransmitter transport - biological_process - GO:0051589 - negative regulation of neurotransmitter transport - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - up regulation of neurotransmitter transport - up-regulation of neurotransmitter transport - upregulation of neurotransmitter transport - activation of neurotransmitter transport - stimulation of neurotransmitter transport - biological_process - GO:0051590 - positive regulation of neurotransmitter transport - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. - biological_process - response to electricity - GO:0051602 - response to electrical stimulus - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. - GOC:ai - - - - - - - - - The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. - stimulus detection - biological_process - perception of stimulus - stimulus sensing - GO:0051606 - - detection of stimulus - - - - - The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. - GOC:add - GOC:ai - GOC:dph - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. - levarterenol reuptake - levarterenol uptake - noradrenaline reuptake - noradrenaline uptake - norepinephrine import - norepinephrine reuptake - biological_process - GO:0051620 - norepinephrine uptake - - - - - The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. - GOC:ai - - - - - norepinephrine import - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell. - regulation of levarterenol uptake - regulation of noradrenaline uptake - regulation of norepinephrine import - biological_process - GO:0051621 - regulation of norepinephrine uptake - - - - - Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell. - GOC:ai - - - - - regulation of norepinephrine import - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell. - down regulation of norepinephrine uptake - down-regulation of norepinephrine uptake - downregulation of norepinephrine uptake - negative regulation of levarterenol uptake - negative regulation of noradrenaline uptake - negative regulation of norepinephrine import - biological_process - GO:0051622 - negative regulation of norepinephrine uptake - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell. - GOC:ai - - - - - negative regulation of norepinephrine import - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell. - positive regulation of levarterenol uptake - positive regulation of noradrenaline uptake - positive regulation of norepinephrine import - up regulation of norepinephrine uptake - up-regulation of norepinephrine uptake - upregulation of norepinephrine uptake - activation of norepinephrine uptake - stimulation of norepinephrine uptake - biological_process - GO:0051623 - positive regulation of norepinephrine uptake - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell. - GOC:ai - - - - - positive regulation of norepinephrine import - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. - acetylcholine import - biological_process - GO:0051630 - acetylcholine uptake - - - - - The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. - GOC:ai - - - - - acetylcholine import - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell. - regulation of acetylcholine import - biological_process - GO:0051631 - regulation of acetylcholine uptake - - - - - Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell. - GOC:ai - - - - - regulation of acetylcholine import - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell. - down regulation of acetylcholine uptake - down-regulation of acetylcholine uptake - downregulation of acetylcholine uptake - negative regulation of acetylcholine import - biological_process - GO:0051632 - negative regulation of acetylcholine uptake - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell. - GOC:ai - - - - - negative regulation of acetylcholine import - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell. - positive regulation of acetylcholine import - up regulation of acetylcholine uptake - up-regulation of acetylcholine uptake - upregulation of acetylcholine uptake - activation of acetylcholine uptake - stimulation of acetylcholine uptake - biological_process - GO:0051633 - positive regulation of acetylcholine uptake - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell. - GOC:ai - - - - - positive regulation of acetylcholine import - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which an organelle is transported to, and/or maintained in, a specific location. - https://github.com/geneontology/go-ontology/issues/19809 - establishment and maintenance of organelle localization - organelle localisation - biological_process - GO:0051640 - - organelle localization - - - - - Any process in which an organelle is transported to, and/or maintained in, a specific location. - GOC:ai - - - - - organelle localisation - GOC:mah - - - - - - - - - - A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane. - jl - 2013-12-18T14:04:32Z - GO:1902580 - cellular localisation - establishment and maintenance of cellular localization - establishment and maintenance of localization in cell or cell membrane - single organism cellular localization - intracellular localization - localization within cell - biological_process - single-organism cellular localization - GO:0051641 - - cellular localization - - - - - A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane. - GOC:tb - GOC:vw - - - - - cellular localisation - GOC:mah - - - - - single organism cellular localization - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. - Golgi apparatus localization - Golgi body localization - Golgi localisation - establishment and maintenance of Golgi localization - biological_process - GO:0051645 - Golgi localization - - - - - Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. - GOC:ai - - - - - Golgi localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. - cell nucleus localization - establishment and maintenance of nucleus localization - localization of nucleus - nucleus localisation - biological_process - GO:0051647 - nucleus localization - - - - - Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. - GOC:ai - - - - - nucleus localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. - cytoplasmic vesicle localization - establishment and maintenance of vesicle localization - vesicle localisation - biological_process - GO:0051648 - vesicle localization - - - - - Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. - GOC:ai - - - - - vesicle localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. - establishment of localisation in cell - establishment of intracellular localization - establishment of localization within cell - positioning within cell - biological_process - establishment of cellular localization - GO:0051649 - establishment of localization in cell - - - - - Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. - GOC:ai - GOC:dos - GOC:dph - GOC:tb - - - - - establishment of localisation in cell - GOC:mah - - - - - establishment of cellular localization - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a vesicle to a specific location. - establishment of vesicle localisation - biological_process - GO:0051650 - establishment of vesicle localization - - - - - The directed movement of a vesicle to a specific location. - GOC:ai - - - - - establishment of vesicle localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of an organelle to a specific location. - establishment of organelle localisation - biological_process - GO:0051656 - establishment of organelle localization - - - - - The directed movement of an organelle to a specific location. - GOC:ai - - - - - establishment of organelle localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. - establishment and maintenance of localization in membrane - establishment and maintenance of position in membrane - localisation within membrane - localization to membrane - positioning within membrane - biological_process - GO:0051668 - localization within membrane - - - - - Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. - GOC:ai - - - - - localisation within membrane - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a cell is transported to, and/or maintained in, a specific location. - cell localization - establishment and maintenance of cell localization - establishment and maintenance of localization of cell - localisation of cell - biological_process - GO:0051674 - localization of cell - - - - - Any process in which a cell is transported to, and/or maintained in, a specific location. - GOC:ai - - - - - localisation of cell - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of the Golgi to a specific location. - establishment of Golgi apparatus localization - establishment of Golgi body localization - establishment of Golgi localisation - biological_process - GO:0051683 - establishment of Golgi localization - - - - - The directed movement of the Golgi to a specific location. - GOC:ai - - - - - establishment of Golgi localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism. - GO:0009613 - GO:0042828 - biological_process - GO:0051707 - response to other organism - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism. - GOC:ai - - - - - - - - - - Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. - biological_process - GO:0051716 - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - cellular response to stimulus - - - - - Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. - GOC:bf - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate or extent of progression through the cell cycle. - GO:0000074 - GO:0007050 - GO:0071156 - GO:0071157 - GO:0071158 - GO:0071850 - cell cycle modulation - cell cycle regulation - control of cell cycle progression - modulation of cell cycle progression - regulation of cell cycle progression - regulation of progression through cell cycle - arrest of mitotic cell cycle progression - cell cycle arrest - mitotic cell cycle arrest - negative regulation of cell cycle arrest - positive regulation of cell cycle arrest - regulation of cell cycle arrest - biological_process - cell cycle regulator - tumor suppressor - GO:0051726 - - regulation of cell cycle - - - - - Any process that modulates the rate or extent of progression through the cell cycle. - GOC:ai - GOC:dph - GOC:tb - - - - - arrest of mitotic cell cycle progression - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cell division. - up regulation of cell division - up-regulation of cell division - upregulation of cell division - activation of cell division - stimulation of cell division - biological_process - GO:0051781 - positive regulation of cell division - - - - - Any process that activates or increases the frequency, rate or extent of cell division. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. - down regulation of cell division - down-regulation of cell division - downregulation of cell division - inhibition of cell division - biological_process - GO:0051782 - negative regulation of cell division - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. - biological_process - GO:0051783 - regulation of nuclear division - - - - - Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. - down regulation of nuclear division - down-regulation of nuclear division - downregulation of nuclear division - inhibition of nuclear division - biological_process - GO:0051784 - negative regulation of nuclear division - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. - up regulation of nuclear division - up-regulation of nuclear division - upregulation of nuclear division - activation of nuclear division - stimulation of nuclear division - biological_process - GO:0051785 - positive regulation of nuclear division - - - - - Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. - pigment granule localisation - biological_process - GO:0051875 - pigment granule localization - - - - - Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. - GOC:ai - - - - - pigment granule localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. - biological_process - GO:0051890 - regulation of cardioblast differentiation - - - - - Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. - up regulation of cardioblast differentiation - up-regulation of cardioblast differentiation - upregulation of cardioblast differentiation - activation of cardioblast differentiation - stimulation of cardioblast differentiation - biological_process - GO:0051891 - positive regulation of cardioblast differentiation - - - - - Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. - down regulation of cardioblast differentiation - down-regulation of cardioblast differentiation - downregulation of cardioblast differentiation - inhibition of cardioblast differentiation - biological_process - GO:0051892 - negative regulation of cardioblast differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - pigment granule translocation - biological_process - GO:0051904 - pigment granule transport - - - - - The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - The directed movement of a pigment granule to a specific location. - establishment of pigment granule localisation - biological_process - GO:0051905 - establishment of pigment granule localization - - - - - The directed movement of a pigment granule to a specific location. - GOC:ai - - - - - establishment of pigment granule localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. - biological_process - GO:0051930 - regulation of sensory perception of pain - - - - - Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. - biological_process - GO:0051931 - regulation of sensory perception - - - - - Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. - biological_process - GO:0051937 - catecholamine transport - - - - - The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. - GOC:ai - ISBN:0198506732 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0051952 - regulation of amine transport - - - - - Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - down regulation of amine transport - down-regulation of amine transport - downregulation of amine transport - inhibition of amine transport - biological_process - GO:0051953 - negative regulation of amine transport - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - up regulation of amine transport - up-regulation of amine transport - upregulation of amine transport - activation of amine transport - stimulation of amine transport - biological_process - GO:0051954 - positive regulation of amine transport - - - - - Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0051955 - regulation of amino acid transport - - - - - Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - down regulation of amino acid transport - down-regulation of amino acid transport - downregulation of amino acid transport - negative regulation of amino acid transmembrane transport - inhibition of amino acid transport - biological_process - GO:0051956 - negative regulation of amino acid transport - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - negative regulation of amino acid transmembrane transport - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - positive regulation of amino acid transmembrane transport - up regulation of amino acid transport - up-regulation of amino acid transport - upregulation of amino acid transport - activation of amino acid transport - stimulation of amino acid transport - biological_process - GO:0051957 - positive regulation of amino acid transport - - - - - Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - positive regulation of amino acid transmembrane transport - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. - biological_process - GO:0051960 - regulation of nervous system development - - - - - Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. - down regulation of nervous system development - down-regulation of nervous system development - downregulation of nervous system development - inhibition of nervous system development - biological_process - GO:0051961 - negative regulation of nervous system development - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. - up regulation of nervous system development - up-regulation of nervous system development - upregulation of nervous system development - activation of nervous system development - stimulation of nervous system development - biological_process - GO:0051962 - positive regulation of nervous system development - - - - - Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. - regulation of synapse biogenesis - regulation of synaptogenesis - biological_process - GO:0051963 - - regulation of synapse assembly - - - - - Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. - GOC:ai - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. - down regulation of synapse assembly - down-regulation of synapse assembly - downregulation of synapse assembly - negative regulation of synapse biogenesis - negative regulation of synaptogenesis - inhibition of synapse assembly - biological_process - GO:0051964 - negative regulation of synapse assembly - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. - GOC:ai - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. - positive regulation of synapse biogenesis - positive regulation of synaptogenesis - up regulation of synapse assembly - up-regulation of synapse assembly - upregulation of synapse assembly - activation of synapse assembly - stimulation of synapse assembly - biological_process - GO:0051965 - positive regulation of synapse assembly - - - - - Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. - GOC:ai - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. - regulation of conduction of nerve impulse - biological_process - GO:0051969 - regulation of transmission of nerve impulse - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. - GOC:ai - - - - - regulation of conduction of nerve impulse - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. - down regulation of transmission of nerve impulse - down-regulation of transmission of nerve impulse - downregulation of transmission of nerve impulse - negative regulation of conduction of nerve impulse - inhibition of transmission of nerve impulse - biological_process - GO:0051970 - negative regulation of transmission of nerve impulse - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. - GOC:ai - - - - - negative regulation of conduction of nerve impulse - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. - positive regulation of conduction of nerve impulse - up regulation of transmission of nerve impulse - up-regulation of transmission of nerve impulse - upregulation of transmission of nerve impulse - activation of transmission of nerve impulse - stimulation of transmission of nerve impulse - biological_process - GO:0051971 - positive regulation of transmission of nerve impulse - - - - - Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. - GOC:ai - - - - - positive regulation of conduction of nerve impulse - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. - biological_process - GO:0051983 - regulation of chromosome segregation - - - - - Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. - up regulation of chromosome segregation - up-regulation of chromosome segregation - upregulation of chromosome segregation - activation of chromosome segregation - stimulation of chromosome segregation - biological_process - GO:0051984 - positive regulation of chromosome segregation - - - - - Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. - down regulation of chromosome segregation - down-regulation of chromosome segregation - downregulation of chromosome segregation - inhibition of chromosome segregation - biological_process - GO:0051985 - negative regulation of chromosome segregation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. - GO:0048747 - muscle fiber development - muscle fibre development - myofiber development - myofibre development - biological_process - GO:0055001 - muscle cell development - - - - - The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. - CL:0000187 - GOC:devbiol - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. - biological_process - GO:0055002 - striated muscle cell development - - - - - The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. - CL:0000737 - GOC:devbiol - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. - cardiac myofibril development - cardiac myofibril morphogenesis - biological_process - heart myofibril assembly - GO:0055003 - cardiac myofibril assembly - - - - - The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. - GOC:devbiol - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. - cardiocyte development - biological_process - heart cell development - GO:0055006 - cardiac cell development - - - - - The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. - GOC:devbiol - - - - - cardiocyte development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. - cardiomyocyte differentiation - biological_process - heart muscle cell differentiation - GO:0055007 - cardiac muscle cell differentiation - - - - - The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. - GOC:devbiol - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of cardiac muscle tissue are generated and organized. - myocardium morphogenesis - heart muscle morphogenesis - biological_process - GO:0055008 - cardiac muscle tissue morphogenesis - - - - - The process in which the anatomical structures of cardiac muscle tissue are generated and organized. - GOC:devbiol - - - - - myocardium morphogenesis - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of cardiac atrium muscle is generated and organized. - atrial heart muscle morphogenesis - atrial myocardium morphogenesis - cardiac atrium muscle morphogenesis - biological_process - GO:0055009 - atrial cardiac muscle tissue morphogenesis - - - - - The process in which the anatomical structure of cardiac atrium muscle is generated and organized. - GOC:devbiol - - - - - atrial myocardium morphogenesis - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. - cardiac ventricle muscle morphogenesis - ventricular heart muscle morphogenesis - biological_process - GO:0055010 - ventricular cardiac muscle tissue morphogenesis - - - - - The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. - GOC:devbiol - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state. - GO:0048739 - cardiac muscle fiber development - cardiac muscle fibre development - cardiomyocyte cell development - heart muscle cell development - biological_process - heart muscle fiber development - GO:0055013 - cardiac muscle cell development - - - - - The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state. - GOC:devbiol - GOC:mtg_heart - - - - - cardiomyocyte cell development - GOC:mtg_muscle - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. - heart muscle growth - biological_process - GO:0055017 - cardiac muscle tissue growth - - - - - The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. - GOC:devbiol - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cardiac muscle fiber development. - regulation of cardiac muscle fibre development - regulation of heart muscle fiber development - biological_process - GO:0055018 - regulation of cardiac muscle fiber development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of cardiac muscle fiber development. - GOC:vk - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development. - down regulation of cardiac muscle fiber development - down-regulation of cardiac muscle fiber development - downregulation of cardiac muscle fiber development - negative regulation of cardiac muscle fibre development - inhibition of cardiac muscle fiber development - biological_process - negative regulation of heart muscle fiber development - GO:0055019 - negative regulation of cardiac muscle fiber development - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development. - GOC:vk - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development. - positive regulation of cardiac muscle fibre development - positive regulation of heart muscle fiber development - up regulation of cardiac muscle fiber development - up-regulation of cardiac muscle fiber development - upregulation of cardiac muscle fiber development - activation of cardiac muscle fiber development - stimulation of cardiac muscle fiber development - biological_process - GO:0055020 - positive regulation of cardiac muscle fiber development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development. - GOC:vk - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cardiac muscle growth. - biological_process - GO:0055021 - regulation of cardiac muscle tissue growth - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of cardiac muscle growth. - GOC:vk - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. - down regulation of cardiac muscle growth - down-regulation of cardiac muscle growth - downregulation of cardiac muscle growth - inhibition of cardiac muscle growth - biological_process - negative regulation of heart muscle growth - GO:0055022 - negative regulation of cardiac muscle tissue growth - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. - GOC:vk - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth. - positive regulation of heart muscle growth - up regulation of cardiac muscle growth - up-regulation of cardiac muscle growth - upregulation of cardiac muscle growth - activation of cardiac muscle growth - stimulation of cardiac muscle growth - biological_process - GO:0055023 - positive regulation of cardiac muscle tissue growth - - - - - Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth. - GOC:vk - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cardiac muscle tissue development. - regulation of heart muscle development - biological_process - GO:0055024 - regulation of cardiac muscle tissue development - - - - - Any process that modulates the frequency, rate or extent of cardiac muscle tissue development. - GOC:vk - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development. - positive regulation of heart muscle development - up regulation of cardiac muscle development - up-regulation of cardiac muscle development - upregulation of cardiac muscle development - activation of cardiac muscle development - stimulation of cardiac muscle development - biological_process - GO:0055025 - positive regulation of cardiac muscle tissue development - - - - - Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development. - GOC:vk - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development. - down regulation of cardiac muscle development - down-regulation of cardiac muscle development - downregulation of cardiac muscle development - negative regulation of heart muscle development - inhibition of cardiac muscle development - biological_process - GO:0055026 - negative regulation of cardiac muscle tissue development - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development. - GOC:vk - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. - neuroblast cell division - biological_process - GO:0055057 - neuroblast division - - - - - The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. - PMID:11163136 - PMID:11250167 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials. - biological_process - GO:0055059 - asymmetric neuroblast division - - - - - The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. - tb - 2015-10-21T13:22:47Z - GO:0090662 - membrane transport - ATP hydrolysis coupled transmembrane transport - biological_process - GO:0055085 - - - - - - Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes. - transmembrane transport - - - - - The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. - GOC:dph - GOC:jid - - - - - - - - - - The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. - nucleobase, nucleoside and nucleotide metabolism - biological_process - nucleobase, nucleoside and nucleotide metabolic process - GO:0055086 - - - - - - nucleobase-containing small molecule metabolic process - - - - - The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex. - biological_process - GO:0055107 - Golgi to secretory granule transport - - - - - The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex. - GOC:curators - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. - biological_process - GO:0055108 - Golgi to transport vesicle transport - - - - - The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cardiac muscle contraction. - biological_process - GO:0055117 - regulation of cardiac muscle contraction - - - - - Any process that modulates the frequency, rate or extent of cardiac muscle contraction. - GOC:ecd - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction. - biological_process - GO:0055118 - negative regulation of cardiac muscle contraction - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction. - GOC:ecd - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. - biological_process - GO:0055123 - digestive system development - - - - - The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. - GOC:jid - - - - - - - - - - - - - - - - - - - - - - - - - - The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. - palatum development - biological_process - GO:0060021 - roof of mouth development - - - - - The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. - GOC:dph - ISBN:0721662544 - - - - - palatum development - ISBN:0721662544 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. - biological_process - GO:0060037 - pharyngeal system development - - - - - The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The expansion of a cardiac muscle cell population by cell division. - cardiac myocyte proliferation - heart muscle cell proliferation - biological_process - cardiomyocyte proliferation - GO:0060038 - cardiac muscle cell proliferation - - - - - The expansion of a cardiac muscle cell population by cell division. - GOC:dph - GOC:rph - PMID:11161571 - - - - - cardiomyocyte proliferation - GOC:dph - PMID:10074473 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. - biological_process - GO:0060039 - pericardium development - - - - - The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. - GOC:dph - GOC:rph - PMID:15138308 - PMID:16376438 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. - GO:0002073 - retina development in camera-style eye - biological_process - retinal development - GO:0060041 - retina development in camera-type eye - - - - - The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. - GOC:bf - GOC:dph - ISBN:0815340729 - - - - - retinal development - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of the retina is generated and organized. - retina morphogenesis in camera-style eye - retinogenesis - biological_process - GO:0060042 - retina morphogenesis in camera-type eye - - - - - The process in which the anatomical structure of the retina is generated and organized. - GOC:bf - GOC:dph - GOC:mtg_sensu - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. - regulation of heart muscle cell proliferation - biological_process - regulation of cardiomyocyte proliferation - GO:0060043 - regulation of cardiac muscle cell proliferation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. - GOC:dph - GOC:rph - - - - - regulation of cardiomyocyte proliferation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation. - negative regulation of heart muscle cell proliferation - biological_process - GO:0060044 - negative regulation of cardiac muscle cell proliferation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation. - GOC:dph - GOC:rph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. - biological_process - positive regulation of heart muscle cell proliferation - GO:0060045 - positive regulation of cardiac muscle cell proliferation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. - GOC:dph - GOC:rph - - - - - - - - - - - - - - - The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body. - heart beating - biological_process - cardiac contraction - hemolymph circulation - GO:0060047 - heart contraction - - - - - The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Muscle contraction of cardiac muscle tissue. - heart muscle contraction - biological_process - GO:0060048 - cardiac muscle contraction - - - - - Muscle contraction of cardiac muscle tissue. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter. - biological_process - serotonin release, neurotransmission - GO:0060096 - serotonin secretion, neurotransmission - - - - - The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter. - GOC:dph - - - - - serotonin release, neurotransmission - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. - biological_process - GO:0060142 - regulation of syncytium formation by plasma membrane fusion - - - - - Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. - biological_process - GO:0060143 - positive regulation of syncytium formation by plasma membrane fusion - - - - - Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The portion of the plasma membrane surrounding a cilium. - GO:0020017 - cilial membrane - cilium membrane - flagellar membrane - flagellum membrane - cellular_component - GO:0060170 - Note that cilia and eukaryotic flagella are deemed to be equivalent. - ciliary membrane - - - - - The portion of the plasma membrane surrounding a cilium. - GOC:cilia - GOC:dph - GOC:rph - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. - Wikipedia:Limb_development - paired limb/fin development - limb bud development - biological_process - GO:0060173 - limb development - - - - - The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. - GOC:dgh - GOC:dph - PMID:11487378 - - - - - limb bud development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. - biological_process - GO:0060214 - endocardium formation - - - - - Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. - GOC:bf - GOC:dph - PMID:17722983 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. - haematopoietic stem cell differentiation - haemopoietic stem cell differentiation - hemopoietic stem cell differentiation - biological_process - GO:0060218 - hematopoietic stem cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. - GOC:BHF - GOC:bf - GOC:dph - GOC:rl - PMID:15378083 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. - biological_process - GO:0060219 - camera-type eye photoreceptor cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell. - biological_process - GO:0060221 - retinal rod cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. - epithelial cell differentiation from mesenchymal cell - mesenchymal-epithelial transition - biological_process - GO:0060231 - mesenchymal to epithelial transition - - - - - A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - epithelial cell differentiation from mesenchymal cell - GOC:BHF - GOC:dph - GOC:rl - - - - - mesenchymal-epithelial transition - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of glial cell proliferation. - biological_process - GO:0060251 - regulation of glial cell proliferation - - - - - Any process that modulates the frequency, rate or extent of glial cell proliferation. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the rate or extent of glial cell proliferation. - biological_process - GO:0060252 - positive regulation of glial cell proliferation - - - - - Any process that activates or increases the rate or extent of glial cell proliferation. - GOC:dph - GOC:sl - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops or decreases the rate or extent of glial cell proliferation. - biological_process - GO:0060253 - negative regulation of glial cell proliferation - - - - - Any process that stops or decreases the rate or extent of glial cell proliferation. - GOC:dph - GOC:sl - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - biological_process - GO:0060255 - regulation of macromolecule metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. - - - - - - - GO:0042384 - Reactome:R-HSA-5617833.2 - ciliogenesis - cilium formation - microtubule-based flagellum assembly - biological_process - cilium biogenesis - cilium morphogenesis - cilium organization - GO:0060271 - Note that we deem cilium and microtubule-based flagellum to be equivalent. - cilium assembly - - - - - The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. - GOC:BHF - GOC:cilia - GOC:dph - GOC:kmv - GOC:pr - GOC:vw - ISBN:0198506732 - PMID:13978319 - PMID:27350441 - Reactome:R-HSA-5617833.2 - - - - - cilium biogenesis - GOC:mah - - - - - cilium organization - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. - biological_process - GO:0060281 - regulation of oocyte development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. - GOC:dph - GOC:tb - PMID:2394318 - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. - biological_process - GO:0060282 - positive regulation of oocyte development - - - - - Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. - biological_process - GO:0060283 - negative regulation of oocyte development - - - - - Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. - biological_process - GO:0060284 - regulation of cell development - - - - - Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. - regulation of sarcomere organisation - biological_process - GO:0060297 - regulation of sarcomere organization - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. - GOC:BHF - GOC:dph - GOC:tb - - - - - regulation of sarcomere organisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. - positive regulation of sarcomere organisation - biological_process - GO:0060298 - positive regulation of sarcomere organization - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. - GOC:BHF - GOC:dph - GOC:tb - - - - - positive regulation of sarcomere organisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. - negative regulation of sarcomere organisation - biological_process - GO:0060299 - negative regulation of sarcomere organization - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. - GOC:BHF - GOC:dph - GOC:tb - - - - - negative regulation of sarcomere organisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. - biological_process - GO:0060322 - head development - - - - - The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. - biological_process - GO:0060323 - head morphogenesis - - - - - The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. - biological_process - GO:0060324 - face development - - - - - The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head. - biological_process - GO:0060325 - face morphogenesis - - - - - The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. - regulation of cellular localisation - biological_process - GO:0060341 - regulation of cellular localization - - - - - Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. - GOC:dph - GOC:tb - - - - - regulation of cellular localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. - trabeculation - biological_process - trabecula biogenesis - GO:0060343 - trabecula formation - - - - - The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. - GOC:dph - - - - - trabeculation - GOC:dph - - - - - trabecula biogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod. - liver trabeculation - biological_process - liver trabecula biogenesis - GO:0060344 - liver trabecula formation - - - - - The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod. - GOC:dph - - - - - liver trabeculation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod. - spleen trabeculation - biological_process - spleen trabecula biogenesis - GO:0060345 - spleen trabecula formation - - - - - The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod. - GOC:dph - - - - - spleen trabeculation - GOC:dph - - - - - spleen trabecula biogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. - cardiac trabecula formation - cardiac trabeculation - heart trabeculation - biological_process - heart trabecula biogenesis - GO:0060347 - heart trabecula formation - - - - - The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. - GOC:dph - - - - - cardiac trabecula formation - GOC:dph - - - - - cardiac trabeculation - GOC:dph - - - - - heart trabeculation - GOC:dph - - - - - heart trabecula biogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. - biological_process - GO:0060348 - bone development - - - - - The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which bones are generated and organized. - biological_process - GO:0060349 - bone morphogenesis - - - - - The process in which bones are generated and organized. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. - biological_process - GO:0060350 - endochondral bone morphogenesis - - - - - The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. - GOC:dph - PMID:11680679 - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. - biological_process - GO:0060351 - cartilage development involved in endochondral bone morphogenesis - - - - - The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. - GO:1903717 - response to ammonia - biological_process - GO:0060359 - response to ammonium ion - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. - GOC:TermGenie - GO_REF:0000071 - PMID:23509267 - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. - myocardial precursor cell differentiation - biological_process - cardiac myoblast differentiation - GO:0060379 - cardiac muscle cell myoblast differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. - GOC:dph - GOC:tb - - - - - myocardial precursor cell differentiation - GOC:mtg_heart - - - - - cardiac myoblast differentiation - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules. - biological_process - GO:0060404 - axonemal microtubule depolymerization - - - - - The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules. - GOC:cilia - GOC:dph - GOC:krc - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. - biological_process - GO:0060408 - regulation of acetylcholine metabolic process - - - - - Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. - biological_process - GO:0060409 - positive regulation of acetylcholine metabolic process - - - - - Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. - biological_process - GO:0060410 - negative regulation of acetylcholine metabolic process - - - - - Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. - GO:0003280 - heart septum morphogenesis - biological_process - GO:0060411 - cardiac septum morphogenesis - - - - - The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. - GOC:dph - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. - interventricular septum morphogenesis - biological_process - GO:0060412 - ventricular septum morphogenesis - - - - - The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. - GOC:dph - - - - - interventricular septum morphogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. - GO:0003287 - interatrial septum morphogenesis - biological_process - GO:0060413 - atrial septum morphogenesis - - - - - The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. - GOC:dph - GOC:mtg_heart - - - - - interatrial septum morphogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. - biological_process - GO:0060414 - aorta smooth muscle tissue morphogenesis - - - - - The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. - GOC:bf - GOC:dgh - GOC:dph - Wikipedia:Aorta - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function. - biological_process - GO:0060415 - muscle tissue morphogenesis - - - - - The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The increase in size or mass of the heart. - biological_process - GO:0060419 - heart growth - - - - - The increase in size or mass of the heart. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. - biological_process - GO:0060420 - regulation of heart growth - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. - biological_process - GO:0060421 - positive regulation of heart growth - - - - - Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. - GOC:BHF - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the lung are generated and organized. - biological_process - GO:0060425 - lung morphogenesis - - - - - The process in which the anatomical structures of the lung are generated and organized. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs. - pulmonary vasculature development - biological_process - GO:0060426 - lung vasculature development - - - - - The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs. - GOC:dph - GOC:mtg_lung - - - - - pulmonary vasculature development - GOC:dph - GOC:mtg_lung - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs. - pulmonary connective tissue development - biological_process - GO:0060427 - lung connective tissue development - - - - - The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs. - GOC:dph - GOC:mtg_lung - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. - pulmonary epithelium development - biological_process - GO:0060428 - lung epithelium development - - - - - The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. - GOC:dph - GOC:mtg_lung - - - - - pulmonary epithelium development - GOC:dph - GOC:mtg_lung - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. - biological_process - GO:0060429 - - epithelium development - - - - - The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. - GOC:dph - GOC:mtg_lung - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds. - lung formation - biological_process - GO:0060431 - primary lung bud formation - - - - - The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds. - GOC:dph - GOC:mtg_lung - - - - - lung formation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. - biological_process - GO:0060437 - lung growth - - - - - The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. - biological_process - GO:0060438 - trachea development - - - - - The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. - biological_process - GO:0060439 - trachea morphogenesis - - - - - The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches. - biological_process - GO:0060440 - trachea formation - - - - - The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. - lung branching morphogenesis - biological_process - GO:0060441 - epithelial tube branching involved in lung morphogenesis - - - - - The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. - GOC:dph - GOC:mtg_lung - - - - - lung branching morphogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. - biological_process - GO:0060450 - positive regulation of hindgut contraction - - - - - Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. - biological_process - GO:0060451 - negative regulation of hindgut contraction - - - - - Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of cardiac muscle contraction. - biological_process - GO:0060452 - positive regulation of cardiac muscle contraction - - - - - Any process that increases the frequency, rate or extent of cardiac muscle contraction. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. - biological_process - GO:0060453 - regulation of gastric acid secretion - - - - - Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. - biological_process - GO:0060454 - positive regulation of gastric acid secretion - - - - - Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. - biological_process - GO:0060455 - negative regulation of gastric acid secretion - - - - - Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. - biological_process - GO:0060456 - positive regulation of digestive system process - - - - - Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. - biological_process - GO:0060457 - negative regulation of digestive system process - - - - - Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect. - right pulmonary development - biological_process - GO:0060458 - right lung development - - - - - The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect. - GOC:dph - GOC:mtg_lung - - - - - right pulmonary development - GOC:dph - GOC:mtg_lung - - - - - - - - - - - - - - - - - - - - - - - - - - The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect. - left pulmonary development - biological_process - GO:0060459 - left lung development - - - - - The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect. - GOC:dph - GOC:mtg_lung - - - - - left pulmonary development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which anatomical structures of the left lung are generated and organized. - biological_process - GO:0060460 - left lung morphogenesis - - - - - The process in which anatomical structures of the left lung are generated and organized. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which anatomical structures of the right lung are generated and organized. - biological_process - GO:0060461 - right lung morphogenesis - - - - - The process in which anatomical structures of the right lung are generated and organized. - GOC:dph - GOC:mtg_lung - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung. - biological_process - GO:0060462 - lung lobe development - - - - - The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung. - biological_process - GO:0060463 - lung lobe morphogenesis - - - - - The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung. - biological_process - GO:0060464 - lung lobe formation - - - - - The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth. - biological_process - pharyngeal development - GO:0060465 - pharynx development - - - - - The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth. - GOC:dph - GOC:rk - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). - biological_process - GO:0060467 - negative regulation of fertilization - - - - - Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). - GOC:dph - - - - - - - - - - - - - - - The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. - pulmonary cell differentiation - biological_process - GO:0060479 - lung cell differentiation - - - - - The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. - GOC:dph - GOC:mtg_lung - - - - - pulmonary cell differentiation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. - mesenchymal development - biological_process - GO:0060485 - mesenchyme development - - - - - The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. - GOC:dph - - - - - mesenchymal development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung. - biological_process - pulmonary epithelial cell differentiation - GO:0060487 - lung epithelial cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung. - GOC:dph - - - - - pulmonary epithelial cell differentiation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of cell projection assembly. - biological_process - regulation of cell projection formation - GO:0060491 - regulation of cell projection assembly - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the rate, frequency, or extent of cell projection assembly. - GOC:dph - GOC:tb - - - - - regulation of cell projection formation - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure. - cell-cell signalling involved in lung development - biological_process - GO:0060495 - cell-cell signaling involved in lung development - - - - - Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure. - GOC:dph - GOC:mtg_lung - - - - - cell-cell signalling involved in lung development - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape. - biological_process - GO:0060501 - positive regulation of epithelial cell proliferation involved in lung morphogenesis - - - - - Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung. - biological_process - GO:0060502 - epithelial cell proliferation involved in lung morphogenesis - - - - - The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of cartilage are generated and organized. - dph - 2009-04-10T09:13:27Z - biological_process - GO:0060536 - cartilage morphogenesis - - - - - The process in which the anatomical structures of cartilage are generated and organized. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. - dph - 2009-04-10T08:05:37Z - biological_process - GO:0060537 - muscle tissue development - - - - - The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. - dph - 2009-04-10T08:25:12Z - biological_process - GO:0060538 - skeletal muscle organ development - - - - - The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs. - - dph - 2009-04-10T08:44:56Z - biological_process - GO:0060539 - diaphragm development - - - - - The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the diaphragm are generated and organized. - - dph - 2009-04-10T08:47:51Z - biological_process - GO:0060540 - diaphragm morphogenesis - - - - - The process in which the anatomical structures of the diaphragm are generated and organized. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. - dph - 2009-04-10T08:55:42Z - biological_process - GO:0060541 - - respiratory system development - - - - - The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. - dph - 2009-04-28T08:42:53Z - differential growth - biological_process - GO:0060560 - developmental growth involved in morphogenesis - - - - - The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. - GOC:dph - - - - - differential growth - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process that contributes to the shaping of an anatomical structure. - dph - 2009-04-28T09:17:27Z - apoptosis involved in morphogenesis - biological_process - apoptosis involved in development - morphogenetic apoptosis - GO:0060561 - apoptotic process involved in morphogenesis - - - - - Any apoptotic process that contributes to the shaping of an anatomical structure. - GOC:dph - GOC:mtg_apoptosis - - - - - morphogenetic apoptosis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. - dph - 2009-04-28T09:33:36Z - biological_process - GO:0060562 - epithelial tube morphogenesis - - - - - The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which epiblast cells acquire specialized features of neuroepithelial cells. - dph - 2009-04-29T01:50:05Z - biological_process - GO:0060563 - neuroepithelial cell differentiation - - - - - The process in which epiblast cells acquire specialized features of neuroepithelial cells. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The morphogenetic process in which an epithelial sheet bends along a linear axis. - dph - 2009-04-30T09:27:17Z - epithelial folding - biological_process - folding of an epithelial sheet - GO:0060571 - morphogenesis of an epithelial fold - - - - - The morphogenetic process in which an epithelial sheet bends along a linear axis. - GOC:dph - - - - - epithelial folding - GOC:dph - - - - - folding of an epithelial sheet - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding. - dph - 2009-04-30T09:38:35Z - biological_process - GO:0060572 - morphogenesis of an epithelial bud - - - - - The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus. - dph - 2009-05-06T08:10:41Z - biological_process - GO:0060574 - intestinal epithelial cell maturation - - - - - The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus. - GOC:dph - PMID:18824147 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. - dph - 2009-05-06T08:17:56Z - biological_process - GO:0060575 - intestinal epithelial cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. - dph - 2009-05-06T08:20:24Z - biological_process - GO:0060576 - intestinal epithelial cell development - - - - - The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart. - dph - 2009-05-06T08:44:04Z - biological_process - pulmonary venous blood vessel morphogenesis - GO:0060577 - pulmonary vein morphogenesis - - - - - The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart. - GOC:dph - - - - - pulmonary venous blood vessel morphogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart. - dph - 2009-05-06T08:47:21Z - biological_process - GO:0060578 - superior vena cava morphogenesis - - - - - The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type. - dph - 2009-05-07T12:40:55Z - biological_process - GO:0060581 - cell fate commitment involved in pattern specification - - - - - The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes. - dph - 2009-05-11T07:47:36Z - biological_process - chondrocyte progenitor cell differentiation - GO:0060591 - chondroblast differentiation - - - - - The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes. - GOC:dph - - - - - chondrocyte progenitor cell differentiation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. - dph - 2009-05-15T12:36:28Z - biological_process - adipogenesis - GO:0060612 - adipose tissue development - - - - - The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. - GOC:dph - - - - - adipogenesis - GOC:mah - GOC:sl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. - dph - 2009-05-18T02:12:13Z - biological_process - GO:0060623 - regulation of chromosome condensation - - - - - Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. - dph - 2009-05-18T02:29:43Z - biological_process - GO:0060627 - regulation of vesicle-mediated transport - - - - - Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. - dph - 2009-05-18T03:07:02Z - biological_process - GO:0060632 - regulation of microtubule-based movement - - - - - Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. - dph - 2009-06-05T12:41:44Z - biological_process - GO:0060688 - regulation of morphogenesis of a branching structure - - - - - Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. - dph - 2009-08-04T12:15:57Z - biological_process - GO:0060788 - ectodermal placode formation - - - - - The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. - GOC:dph - GOC:sdb_2009 - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. - dph - 2009-08-04T03:11:22Z - biological_process - GO:0060795 - cell fate commitment involved in formation of primary germ layer - - - - - The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. - GOC:dph - GOC:sdb_2009 - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels. - dph - 2009-08-11T03:47:36Z - biological_process - GO:0060837 - blood vessel endothelial cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels. - GOC:dph - GOC:sdb_2009 - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. - dph - 2009-08-12T10:10:51Z - biological_process - GO:0060840 - artery development - - - - - The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. - GOC:dph - GOC:sdb_2009 - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. - dph - 2009-08-12T10:14:07Z - biological_process - GO:0060841 - venous blood vessel development - - - - - The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. - GOC:dph - GOC:sdb_2009 - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries. - dph - 2009-08-12T10:41:34Z - biological_process - GO:0060842 - arterial endothelial cell differentiation - - - - - The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries. - GOC:dph - GOC:sdb_2009 - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins. - dph - 2009-08-12T10:43:40Z - biological_process - GO:0060843 - venous endothelial cell differentiation - - - - - The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins. - GOC:dph - GOC:sdb_2009 - GOC:tb - - - - - - - - - The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate. - dph - 2009-08-13T02:06:27Z - biological_process - GO:0060896 - neural plate pattern specification - - - - - The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate. - GOC:dph - GOC:sdb_2009 - GOC:tb - - - - - - - - - - The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. - dph - 2009-08-13T02:09:04Z - biological_process - GO:0060897 - neural plate regionalization - - - - - The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. - GOC:dph - GOC:sdb_2009 - GOC:tb - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. - dph - 2009-08-13T02:26:54Z - biological_process - GO:0060900 - embryonic camera-type eye formation - - - - - The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. - GOC:dph - GOC:sdb_2009 - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable. - dph - 2009-09-17T09:02:13Z - biological_process - cardiogenesis - GO:0060914 - heart formation - - - - - The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable. - GOC:mtg_heart - - - - - cardiogenesis - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. - dph - 2009-09-18T11:45:33Z - biological_process - GO:0060915 - mesenchymal cell differentiation involved in lung development - - - - - The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. - dph - 2009-09-18T11:50:17Z - biological_process - GO:0060916 - mesenchymal cell proliferation involved in lung development - - - - - The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. - dph - 2009-09-29T11:01:31Z - pacemaker cell differentiation - biological_process - GO:0060920 - cardiac pacemaker cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. - GOC:mtg_cardiac_conduct_nov11 - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node. - dph - 2009-09-29T11:03:30Z - SA node cell differentiation - SAN cell differentiation - sinus node cell differentiation - biological_process - GO:0060921 - sinoatrial node cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node. - GOC:mtg_heart - - - - - SA node cell differentiation - GOC:mtg_heart - - - - - SAN cell differentiation - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - sinus node cell differentiation - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node. - dph - 2009-09-29T11:07:06Z - biological_process - AV node cell differentiation - GO:0060922 - atrioventricular node cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node. - GOC:mtg_heart - - - - - AV node cell differentiation - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. - dph - 2009-09-29T11:51:55Z - pacemaker cell development - biological_process - GO:0060926 - cardiac pacemaker cell development - - - - - The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. - GOC:mtg_cardiac_conduct_nov11 - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state. - dph - 2009-09-29T11:59:26Z - AV node cell development - biological_process - GO:0060928 - atrioventricular node cell development - - - - - The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state. - GOC:mtg_heart - - - - - AV node cell development - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node. - dph - 2009-09-29T12:05:47Z - SA node cell development - SAN cell development - sinus node cell development - biological_process - GO:0060931 - sinoatrial node cell development - - - - - The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node. - GOC:mtg_heart - - - - - SA node cell development - GOC:mtg_heart - - - - - SAN cell development - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - sinus node cell development - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles. - dph - 2009-09-29T01:10:32Z - biological_process - GO:0060932 - His-Purkinje system cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles. - dph - 2009-09-29T01:15:02Z - biological_process - GO:0060933 - His-Purkinje system cell development - - - - - The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. - dph - 2009-09-29T01:20:04Z - biological_process - GO:0060935 - cardiac fibroblast cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules. - dph - 2009-09-29T01:23:03Z - biological_process - GO:0060936 - cardiac fibroblast cell development - - - - - The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart. - dph - 2009-09-29T02:45:33Z - heart neuron differentiation - biological_process - GO:0060945 - cardiac neuron differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart. - GOC:mtg_heart - - - - - heart neuron differentiation - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels. - dph - 2009-09-29T02:48:55Z - biological_process - GO:0060946 - cardiac blood vessel endothelial cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart. - dph - 2009-09-29T03:06:37Z - biological_process - GO:0060950 - cardiac glial cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell. - dph - 2009-09-29T03:09:24Z - biological_process - GO:0060952 - cardiac glial cell development - - - - - The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers. - dph - 2009-09-29T03:20:39Z - biological_process - GO:0060956 - endocardial cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. - dph - 2009-09-29T03:26:59Z - biological_process - GO:0060958 - endocardial cell development - - - - - The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state. - dph - 2009-09-30T10:14:56Z - heart neuron development - biological_process - GO:0060959 - cardiac neuron development - - - - - The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state. - GOC:mtg_heart - - - - - heart neuron development - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. - dph - 2009-10-06T10:53:49Z - biological_process - GO:0060973 - cell migration involved in heart development - - - - - The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells. - dph - 2009-10-06T10:56:33Z - biological_process - GO:0060974 - cell migration involved in heart formation - - - - - The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. - dph - 2009-10-06T12:15:23Z - cardiac blood vessel development - cardiac vasculature development - coronary blood vessel development - heart blood vessel development - heart vasculature development - biological_process - GO:0060976 - coronary vasculature development - - - - - The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. - GOC:mtg_heart - - - - - cardiac blood vessel development - GOC:mtg_heart - - - - - cardiac vasculature development - GOC:mtg_heart - - - - - coronary blood vessel development - GOC:mtg_heart - - - - - heart blood vessel development - GOC:mtg_heart - - - - - heart vasculature development - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood. - dph - 2009-10-06T12:28:23Z - cardiac blood vessel morphogenesis - cardiac vasculature morphogenesis - coronary blood vessel morphogenesis - heart blood vessel morphogenesis - heart vasculature morphogenesis - biological_process - GO:0060977 - coronary vasculature morphogenesis - - - - - The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood. - GOC:mtg_heart - - - - - cardiac blood vessel morphogenesis - GOC:mtg_heart - - - - - cardiac vasculature morphogenesis - GOC:mtg_heart - - - - - coronary blood vessel morphogenesis - GOC:mtg_heart - - - - - heart blood vessel morphogenesis - GOC:mtg_heart - - - - - heart vasculature morphogenesis - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels. - dph - 2009-10-06T02:02:12Z - angiogenesis involved in cardiac vascular morphogenesis - angiogenesis involved in heart vascular morphogenesis - coronary blood vessel angiogenesis - coronary vasculature angiogenesis - biological_process - GO:0060978 - angiogenesis involved in coronary vascular morphogenesis - - - - - Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels. - GOC:mtg_heart - - - - - angiogenesis involved in cardiac vascular morphogenesis - GOC:mtg_heart - - - - - angiogenesis involved in heart vascular morphogenesis - GOC:mtg_heart - - - - - coronary blood vessel angiogenesis - GOC:mtg_heart - - - - - coronary vasculature angiogenesis - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes. - dph - 2009-10-06T02:19:42Z - coronary vasculogenesis - vasculogenesis involved in coronary blood vessel morphogenesis - biological_process - GO:0060979 - vasculogenesis involved in coronary vascular morphogenesis - - - - - The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes. - GOC:mtg_heart - - - - - coronary vasculogenesis - GOC:mtg_heart - - - - - vasculogenesis involved in coronary blood vessel morphogenesis - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - - The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart. - dph - 2009-10-06T02:33:06Z - biological_process - GO:0060980 - cell migration involved in coronary vasculogenesis - - - - - The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart. - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels. - dph - 2009-10-06T02:49:12Z - biological_process - GO:0060981 - cell migration involved in coronary angiogenesis - - - - - The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels. - GOC:mtg_heart - - - - - - - - - - - - - - - The regulated release of a hormone into the circulatory system. - dph - 2010-01-11T09:03:48Z - biological_process - GO:0060986 - endocrine hormone secretion - - - - - The regulated release of a hormone into the circulatory system. - GOC:dph - - - - - - - - - An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. - dph - 2010-01-22T09:09:10Z - hepatobiliary system process - biological_process - GO:0061007 - - hepaticobiliary system process - - - - - An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. - GOC:dph - - - - - hepatobiliary system process - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. - dph - 2010-01-22T09:11:59Z - hepatobiliary system development - biological_process - GO:0061008 - hepaticobiliary system development - - - - - The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. - GOC:dph - - - - - hepatobiliary system development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine. - dph - 2010-01-22T09:17:13Z - EHBD development - extrahepatic bile duct development - CBD development - bile duct development - biological_process - GO:0061009 - common bile duct development - - - - - The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine. - PMID:20614624 - - - - - EHBD development - PMID:20614624 - - - - - extrahepatic bile duct development - PMID:20614624 - - - - - CBD development - PMID:20614624 - - - - - bile duct development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile. - dph - 2010-01-22T09:38:44Z - biological_process - GO:0061010 - gallbladder development - - - - - The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct. - dph - 2010-01-22T09:44:39Z - biological_process - GO:0061011 - hepatic duct development - - - - - The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct. - GOC:dph - PMID:20614624 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes. - dph - 2010-02-02T09:08:03Z - biological_process - GO:0061017 - hepatoblast differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes. - GOC:dph - PMID:15226394 - - - - - - - - - - - - - - - - - - - - - - - - - - A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. - jl - 2010-02-08T02:43:11Z - GO:0016044 - GO:0044802 - cellular membrane organisation - cellular membrane organization - membrane organisation - biological_process - membrane organization and biogenesis - single-organism membrane organization - GO:0061024 - - - - - - - membrane organization - - - - - A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. - GOC:dph - GOC:tb - - - - - membrane organisation - GOC:mah - - - - - membrane organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The membrane organization process that joins two lipid bilayers to form a single membrane. - jl - 2010-02-08T02:48:06Z - GO:0006944 - GO:0044801 - Wikipedia:Lipid_bilayer_fusion - cellular membrane fusion - biological_process - single-organism membrane fusion - GO:0061025 - - membrane fusion - - - - - The membrane organization process that joins two lipid bilayers to form a single membrane. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium. - dph - 2010-02-09T09:52:49Z - epicardium development - biological_process - GO:0061032 - visceral serous pericardium development - - - - - The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium. - GOC:dph - GOC:yaf - - - - - epicardium development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. - dph - 2010-02-09T03:41:35Z - biological_process - GO:0061035 - regulation of cartilage development - - - - - Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. - dph - 2010-02-09T03:41:35Z - biological_process - GO:0061036 - positive regulation of cartilage development - - - - - Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. - dph - 2010-02-09T03:41:35Z - biological_process - GO:0061037 - negative regulation of cartilage development - - - - - Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a female gonad is generated and organized. - dph - 2010-02-22T11:29:28Z - biological_process - ovary morphogenesis - GO:0061040 - female gonad morphogenesis - - - - - The process in which a female gonad is generated and organized. - GOC:BHF - GOC:dph - - - - - ovary morphogenesis - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. - dph - 2010-02-25T10:41:38Z - biological_process - GO:0061046 - regulation of branching involved in lung morphogenesis - - - - - Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. - GOC:dph - GOC:yaf - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. - dph - 2010-02-25T10:50:01Z - biological_process - GO:0061047 - positive regulation of branching involved in lung morphogenesis - - - - - Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. - GOC:dph - GOC:yaf - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. - dph - 2010-02-25T10:51:31Z - biological_process - GO:0061048 - negative regulation of branching involved in lung morphogenesis - - - - - Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. - GOC:dph - GOC:yaf - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. - dph - 2010-02-25T12:56:07Z - biological_process - cardiac muscle cell hypertrophy - cardiomyocyte growth - heart muscle cell growth - GO:0061049 - cell growth involved in cardiac muscle cell development - - - - - The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. - GOC:dph - - - - - cardiac muscle cell hypertrophy - GOC:dph - - - - - cardiomyocyte growth - GOC:dph - - - - - heart muscle cell growth - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. - dph - 2010-02-25T01:05:16Z - biological_process - GO:0061050 - regulation of cell growth involved in cardiac muscle cell development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. - dph - 2010-02-25T01:08:08Z - biological_process - GO:0061051 - positive regulation of cell growth involved in cardiac muscle cell development - - - - - Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. - dph - 2010-02-25T01:11:30Z - biological_process - GO:0061052 - negative regulation of cell growth involved in cardiac muscle cell development - - - - - Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. - dph - 2010-03-02T12:05:13Z - biological_process - GO:0061053 - somite development - - - - - The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. - dph - 2010-03-02T12:07:37Z - biological_process - GO:0061054 - dermatome development - - - - - The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle. - dph - 2010-03-02T12:11:01Z - biological_process - GO:0061055 - myotome development - - - - - The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. - dph - 2010-03-02T12:12:40Z - biological_process - GO:0061056 - sclerotome development - - - - - The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. - dph - 2010-03-09T08:55:14Z - biological_process - GO:0061061 - - muscle structure development - - - - - The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. - dph - 2010-03-11T12:59:21Z - biological_process - GO:0061062 - regulation of nematode larval development - - - - - Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. - GOC:dph - GOC:kmv - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. - dph - 2010-03-11T01:03:34Z - biological_process - GO:0061063 - positive regulation of nematode larval development - - - - - Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. - GOC:dph - GOC:kmv - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. - dph - 2010-03-11T01:04:39Z - biological_process - GO:0061064 - negative regulation of nematode larval development - - - - - Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. - GOC:dph - GOC:kmv - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina. - dph - 2010-03-16T10:48:42Z - biological_process - GO:0061072 - iris morphogenesis - - - - - The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes. - dph - 2010-03-16T10:55:19Z - biological_process - GO:0061073 - ciliary body morphogenesis - - - - - The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. - dph - 2010-03-16T11:47:05Z - biological_process - GO:0061074 - regulation of neural retina development - - - - - Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. - dph - 2010-03-16T11:59:48Z - biological_process - GO:0061075 - positive regulation of neural retina development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. - dph - 2010-03-16T12:46:11Z - biological_process - GO:0061076 - negative regulation of neural retina development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the right horn of the sinus venosus from its formation to the mature structure. - dph - 2010-04-08T02:45:10Z - biological_process - GO:0061080 - right horn of sinus venosus development - - - - - The progression of the right horn of the sinus venosus from its formation to the mature structure. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium. - dph - 2010-04-27T03:28:46Z - biological_process - GO:0061100 - lung neuroendocrine cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium. - GOC:dph - PMID:9126746 - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance. - dph - 2010-04-28T09:42:20Z - biological_process - GO:0061101 - neuroendocrine cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium. - dph - 2010-04-28T09:47:07Z - biological_process - gastric neuroendocrine cell differentiation - GO:0061102 - stomach neuroendocrine cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium. - GOC:dph - PMID:18173746 - - - - - gastric neuroendocrine cell differentiation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. - dph - 2010-04-29T12:19:37Z - biological_process - GO:0061105 - regulation of stomach neuroendocrine cell differentiation - - - - - Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. - dph - 2010-04-29T12:23:05Z - biological_process - GO:0061106 - negative regulation of stomach neuroendocrine cell differentiation - - - - - Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells. - dph - 2010-05-01T09:34:37Z - dense core granule organisation - biological_process - GO:0061109 - dense core granule organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells. - GOC:dph - - - - - dense core granule organisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized. - dph - 2010-05-05T11:55:30Z - biological_process - GO:0061113 - pancreas morphogenesis - - - - - Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the branches of the pancreas are generated and organized. - dph - 2010-05-05T12:03:04Z - biological_process - GO:0061114 - branching involved in pancreas morphogenesis - - - - - The process in which the branches of the pancreas are generated and organized. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. - dph - 2010-05-17T07:31:28Z - biological_process - GO:0061117 - negative regulation of heart growth - - - - - Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. - GOC:dph - GOC:hjd - - - - - - - - - - - - - - - - - - - - - - - - - - - - The morphogenetic process in which the foregut region specified to become the pancreas forms a bud. - dph - 2010-05-17T09:33:40Z - biological_process - GO:0061130 - pancreatic bud formation - - - - - The morphogenetic process in which the foregut region specified to become the pancreas forms a bud. - GOC:dph - - - - - - - - - - The process in which the anatomical structures of a branched epithelium are generated and organized. - dph - 2010-05-25T09:05:34Z - biological_process - GO:0061138 - morphogenesis of a branching epithelium - - - - - The process in which the anatomical structures of a branched epithelium are generated and organized. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part. - dph - 2010-05-25T09:28:53Z - biological_process - GO:0061140 - lung secretory cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells. - dph - 2010-05-25T09:31:14Z - biological_process - GO:0061141 - lung ciliated cell differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells. - GOC:cilia - GOC:dph - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. - dph - 2010-06-03T09:15:31Z - biological_process - GO:0061147 - endocardial endothelium development - - - - - The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. - dph - 2010-06-03T09:18:02Z - extracellular matrix organisation involved in endocardium development - biological_process - GO:0061148 - extracellular matrix organization involved in endocardium development - - - - - A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. - GOC:dph - - - - - extracellular matrix organisation involved in endocardium development - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. - dph - 2010-06-15T09:05:00Z - biological_process - GO:0061154 - endothelial tube morphogenesis - - - - - The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. - GOC:dph - GOC:yaf - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery. - dph - 2010-06-15T09:09:04Z - biological_process - GO:0061155 - pulmonary artery endothelial tube morphogenesis - - - - - The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery. - GOC:dph - GOC:yaf - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs. - dph - 2010-06-15T09:13:47Z - biological_process - GO:0061156 - pulmonary artery morphogenesis - - - - - The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs. - GOC:dph - GOC:yaf - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. - dph - 2010-07-14T08:28:52Z - biological_process - GO:0061181 - regulation of chondrocyte development - - - - - Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. - GOC:BHF - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. - dph - 2010-07-14T08:33:05Z - biological_process - GO:0061182 - negative regulation of chondrocyte development - - - - - Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. - GOC:BHF - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. - dph - 2010-07-14T08:40:26Z - biological_process - GO:0061183 - regulation of dermatome development - - - - - Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. - GOC:BHF - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. - dph - 2010-07-14T08:42:03Z - biological_process - GO:0061184 - positive regulation of dermatome development - - - - - Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. - GOC:BHF - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. - dph - 2010-07-14T08:43:08Z - biological_process - GO:0061185 - negative regulation of dermatome development - - - - - Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. - GOC:BHF - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. - dph - 2010-07-14T09:17:23Z - biological_process - GO:0061189 - positive regulation of sclerotome development - - - - - Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. - GOC:BHF - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. - dph - 2010-07-14T09:19:47Z - biological_process - GO:0061190 - regulation of sclerotome development - - - - - Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. - dph - 2010-09-06T03:27:06Z - retinal vasculature development - biological_process - GO:0061298 - retina vasculature development in camera-type eye - - - - - The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. - GOC:BHF - GOC:dph - - - - - retinal vasculature development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the vasculature of the retina is generated and organized. - dph - 2010-09-06T03:28:25Z - retinal vasculature morphogenesis - biological_process - GO:0061299 - retina vasculature morphogenesis in camera-type eye - - - - - The process in which the vasculature of the retina is generated and organized. - GOC:BHF - GOC:dph - - - - - retinal vasculature morphogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye. - dph - 2010-09-14T02:09:08Z - biological_process - GO:0061303 - cornea development in camera-type eye - - - - - The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure. - dph - 2010-09-16T09:02:59Z - biological_process - GO:0061304 - retinal blood vessel morphogenesis - - - - - The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure. - GOC:BHF - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches. - dph - 2010-09-23T08:50:56Z - biological_process - GO:0061307 - cardiac neural crest cell differentiation involved in heart development - - - - - The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches. - GOC:dph - GOC:mtg_heart - PMID:19705442 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart. - dph - 2010-09-23T09:01:49Z - biological_process - GO:0061308 - cardiac neural crest cell development involved in heart development - - - - - The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart. - GOC:dph - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract. - dph - 2010-09-23T09:08:37Z - biological_process - GO:0061309 - cardiac neural crest cell development involved in outflow tract morphogenesis - - - - - The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract. - GOC:dph - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart. - dph - 2010-09-28T09:05:26Z - biological_process - GO:0061323 - cell proliferation involved in heart morphogenesis - - - - - The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart. - GOC:dph - GOC:mtg_heart - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract. - dph - 2010-09-28T09:29:30Z - biological_process - GO:0061325 - cell proliferation involved in outflow tract morphogenesis - - - - - The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract. - GOC:dph - GOC:mtg_heart - - - - - - - - - Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. - dph - 2010-09-29T08:46:05Z - biological_process - GO:0061337 - cardiac conduction - - - - - Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. - GOC:dph - - - - - - - - - The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. - dph - 2010-10-01T11:06:04Z - biological_process - GO:0061351 - neural precursor cell proliferation - - - - - The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. - GOC:dph - GOC:yaf - - - - - - - - - - - - - - - - - - - - - - - - - - The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. - dph - 2010-12-02T08:51:45Z - biological_process - GO:0061383 - trabecula morphogenesis - - - - - The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. - dph - 2010-12-02T08:54:20Z - biological_process - GO:0061384 - heart trabecula morphogenesis - - - - - The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart. - dph - 2011-02-10T01:41:59Z - biological_process - GO:0061385 - fibroblast proliferation involved in heart morphogenesis - - - - - The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of a connective tissue over time, from its formation to the mature structure. - dph - 2012-03-22T12:53:41Z - biological_process - GO:0061448 - connective tissue development - - - - - The progression of a connective tissue over time, from its formation to the mature structure. - GOC:BHF - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction. - dph - 2012-07-20T08:20:50Z - biological_process - ICC differentiation - GO:0061453 - interstitial cell of Cajal differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction. - GOC:dph - - - - - ICC differentiation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. - dph - 2012-08-22T17:47:53Z - biological_process - GO:0061458 - reproductive system development - - - - - The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation. - dph - 2012-11-01T13:16:23Z - biological_process - GO:0061469 - regulation of type B pancreatic cell proliferation - - - - - Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells. - dph - 2012-12-04T09:41:02Z - biological_process - GO:0061484 - hematopoietic stem cell homeostasis - - - - - Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells. - GOC:dph - PMID:21508411 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, a location within a cilium. - - - - - - - dph - 2013-03-22T15:41:44Z - biological_process - GO:0061512 - protein localization to cilium - - - - - A process in which a protein is transported to, or maintained in, a location within a cilium. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. - dph - 2013-04-18T13:03:16Z - biological_process - GO:0061515 - myeloid cell development - - - - - The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - A cellular process that results in the breakdown of a cilium. - dph - 2013-04-18T14:59:59Z - cilium resorption - biological_process - GO:0061523 - Note that we deem cilium and microtubule-based flagellum to be equivalent. - cilium disassembly - - - - - A cellular process that results in the breakdown of a cilium. - GOC:cilia - GOC:dph - PMID:17604723 - PMID:27350441 - - - - - cilium resorption - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut. - dph - 2013-06-14T11:22:21Z - biological_process - GO:0061525 - hindgut development - - - - - The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - The regulated release of acetylcholine by a cell. - dph - 2013-06-21T15:40:39Z - biological_process - GO:0061526 - acetylcholine secretion - - - - - The regulated release of acetylcholine by a cell. - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter. - dph - 2013-06-21T16:05:08Z - noradrenaline secretion, neurotransmission - biological_process - GO:0061533 - norepinephrine secretion, neurotransmission - - - - - The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter. - GOC:dph - - - - - noradrenaline secretion, neurotransmission - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. - dph - 2013-07-10T08:36:12Z - gangliogenesis - biological_process - ganglia development - GO:0061548 - ganglion development - - - - - The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. - GOC:dph - - - - - gangliogenesis - GOC:BHF - GOC:rl - - - - - ganglia development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure. - dph - 2013-07-10T08:38:01Z - biological_process - sympathetic ganglia development - GO:0061549 - sympathetic ganglion development - - - - - The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure. - GOC:BHF - GOC:rl - - - - - sympathetic ganglia development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure. - dph - 2013-07-10T08:40:14Z - biological_process - cranial ganglia development - GO:0061550 - cranial ganglion development - - - - - The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure. - GOC:dph - - - - - cranial ganglia development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure. - dph - 2013-07-10T08:42:19Z - biological_process - trigeminal ganglia development - GO:0061551 - trigeminal ganglion development - - - - - The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure. - GOC:dph - - - - - trigeminal ganglia development - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of ganglion are generated and organized. - dph - 2013-07-10T08:44:57Z - biological_process - ganglia morphogenesis - GO:0061552 - ganglion morphogenesis - - - - - The process in which the anatomical structures of ganglion are generated and organized. - GOC:dph - - - - - ganglia morphogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state. - dph - 2013-07-10T08:45:59Z - biological_process - ganglia maturation - GO:0061553 - ganglion maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state. - GOC:dph - - - - - ganglia maturation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts. - dph - 2013-07-10T08:51:50Z - biological_process - ganglia formation - GO:0061554 - ganglion formation - - - - - The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts. - GOC:dph - - - - - ganglia formation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of a trigeminal ganglion is generated and organized. - dph - 2013-07-10T08:57:12Z - biological_process - trigeminal ganglia morphogenesis - GO:0061556 - trigeminal ganglion morphogenesis - - - - - The process in which the anatomical structure of a trigeminal ganglion is generated and organized. - GOC:dph - - - - - trigeminal ganglia morphogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state. - dph - 2013-07-10T08:58:24Z - biological_process - trigeminal ganglia maturation - GO:0061557 - trigeminal ganglion maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state. - GOC:dph - - - - - trigeminal ganglia maturation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state. - dph - 2013-07-10T08:59:52Z - biological_process - cranial ganglia maturation - GO:0061558 - cranial ganglion maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state. - GOC:dph - - - - - cranial ganglia maturation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structure of a cranial ganglion is generated and organized. - dph - 2013-07-10T09:02:15Z - biological_process - cranial ganglia morphogenesis - GO:0061559 - cranial ganglion morphogenesis - - - - - The process in which the anatomical structure of a cranial ganglion is generated and organized. - GOC:dph - - - - - cranial ganglia morphogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts. - dph - 2013-07-10T09:07:27Z - biological_process - cranial ganglia formation - GO:0061560 - cranial ganglion formation - - - - - The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts. - GOC:dph - - - - - cranial ganglia formation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts. - dph - 2013-07-10T09:08:13Z - biological_process - trigeminal ganglia formation - GO:0061561 - trigeminal ganglion formation - - - - - The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts. - GOC:dph - - - - - trigeminal ganglia formation - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. - dph - 2013-08-02T11:24:11Z - biological_process - actin filament cable organization - GO:0061572 - actin filament bundle organization - - - - - A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. - GOC:dph - - - - - actin filament cable organization - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery. - dph - 2014-05-09T15:34:06Z - aortic arch artery morphogenesis - biological_process - GO:0061626 - pharyngeal arch artery morphogenesis - - - - - The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery. - GOC:BHF - GOC:dph - PMID:20122914 - - - - - aortic arch artery morphogenesis - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds. - dph - 2015-03-09T09:16:23Z - biological_process - GO:0061687 - detoxification of inorganic compound - - - - - Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds. - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). - dph - 2015-05-06T11:22:38Z - cellular_component - GO:0061695 - transferase complex, transferring phosphorus-containing groups - - - - - A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). - GOC:bhm - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - - Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling. - dph - 2016-09-09T13:24:34Z - biological_process - GO:0061792 - secretory granule maturation - - - - - Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling. - GOC:PARL - GOC:bf - GOC:dph - PMID:16618809 - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to or maintained in a location within the somatodendritic compartment. - dph - 2017-09-08T13:22:26Z - somatodendritic protein localization - biological_process - GO:0061938 - protein localization to somatodendritic compartment - - - - - A process in which a protein is transported to or maintained in a location within the somatodendritic compartment. - PMID:18341993 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a protein to a specific location in a plasma membrane. - dph - 2017-10-26T12:55:15Z - biological_process - GO:0061951 - establishment of protein localization to plasma membrane - - - - - The directed movement of a protein to a specific location in a plasma membrane. - GOC:dph - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone. - dph - 2018-02-12T18:10:59Z - biological_process - GO:0061971 - replacement bone morphogenesis - - - - - The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone. - PMID:29852585 - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which bone which forms superficially in the organism are generated and organized. - dph - 2018-02-12T18:16:21Z - biological_process - GO:0061972 - dermal bone morphogenesis - - - - - The process in which bone which forms superficially in the organism are generated and organized. - PMID:12588850 - PMID:15003632 - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which bone which forms deep in the organism are generated and organized. - dph - 2018-02-12T18:21:09Z - biological_process - GO:0061973 - membrane bone morphogenesis - - - - - The process in which bone which forms deep in the organism are generated and organized. - PMID:14579374 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of a small molecule metabolic process. - dph - 2018-03-19T14:11:54Z - regulation of small molecule metabolism - biological_process - GO:0062012 - regulation of small molecule metabolic process - - - - - Any process that modulates the rate, frequency or extent of a small molecule metabolic process. - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process. - dph - 2018-03-19T14:25:10Z - positive regulation of small molecule metabolism - biological_process - GO:0062013 - positive regulation of small molecule metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process. - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process. - dph - 2018-03-19T14:27:23Z - negative regulation of small molecule metabolism - biological_process - GO:0062014 - negative regulation of small molecule metabolic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process. - GOC:vw - - - - - - - - - - - - - - - - - - - - - An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. - dph - 2018-04-13T12:47:21Z - cellular_component - GO:0062023 - collagen-containing extracellular matrix - - - - - An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. - GOC:BHF - GOC:rph - PMID:21123617 - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis. - dph - 2018-04-23T14:32:23Z - biological_process - GO:0062033 - positive regulation of mitotic sister chromatid segregation - - - - - Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis. - PMID:12773390 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. - dph - 2018-11-20T18:15:45Z - biological_process - GO:0062094 - stomach development - - - - - The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. - PMID:11967278 - - - - - - - - - - - - - - - - - - - - - - - - - - The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal. - dph - 2019-09-13T13:48:47Z - biological_process - GO:0062149 - detection of stimulus involved in sensory perception of pain - - - - - The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal. - PMID:19837031 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell. - dph - 2020-04-20T13:58:43Z - biological_process - GO:0062237 - protein localization to postsynapse - - - - - Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell. - PMID:31189538 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. - intracellular membrane translocation of a protein - intracellular protein membrane transport - intracellular protein transport across a membrane - biological_process - GO:0065002 - Note that this term is not intended for use in annotating lateral movement within membranes. - intracellular protein transmembrane transport - - - - - The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. - GOC:isa_complete - - - - - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. - https://github.com/geneontology/go-ontology/issues/22580 - GO:0006461 - GO:0034622 - GO:0043623 - cellular protein complex assembly - biological_process - cellular macromolecule complex assembly - cellular protein-containing complex assembly - chaperone activity - macromolecular complex assembly - macromolecule complex assembly - protein complex assembly - protein complex formation - GO:0065003 - - - - - - - - protein-containing complex assembly - - - - - The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. - DNA-protein complex assembly - biological_process - GO:0065004 - protein-DNA complex assembly - - - - - The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. - GOC:jl - - - - - DNA-protein complex assembly - GOC:mah - - - - - - - - - Any process that modulates a measurable attribute of any biological process, quality or function. - regulation - biological_process - GO:0065007 - - - biological regulation - - - - - Any process that modulates a measurable attribute of any biological process, quality or function. - GOC:dph - GOC:isa_complete - GOC:mah - GOC:pr - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. - regulation of a molecular function - biological_process - GO:0065009 - - - - regulation of molecular function - - - - - Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. - GOC:isa_complete - - - - - - - - - - - - - - - - - - - - - - - - - - - Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. - extracellular membrane-enclosed organelle - cellular_component - GO:0065010 - extracellular membrane-bounded organelle - - - - - Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. - GOC:isa_complete - - - - - - - - - - - - - - - - - - - - - - - - - - An organelle lumen that is part of an intracellular organelle. - cellular_component - GO:0070013 - intracellular organelle lumen - - - - - An organelle lumen that is part of an intracellular organelle. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. - https://github.com/geneontology/go-ontology/issues/24218 - neuron maintenance - biological_process - GO:0070050 - neuron cellular homeostasis - - - - - The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. - GOC:BHF - GOC:mah - - - - - - - - - - - - - - - A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. - exosome - extracellular vesicular exosome - cellular_component - GO:0070062 - extracellular exosome - - - - - A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. - GOC:BHF - GOC:mah - GOC:vesicles - PMID:15908444 - PMID:17641064 - PMID:19442504 - PMID:19498381 - PMID:22418571 - PMID:24009894 - - - - - exosome - GOC:pr - - - - - extracellular vesicular exosome - GOC:vesicles - - - - - - - - - - - - - - - - - - - - - - - - - - The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans). - biological_process - GO:0070091 - glucagon secretion - - - - - The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans). - GOC:BHF - GOC:rl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the regulated release of glucagon. - biological_process - GO:0070092 - regulation of glucagon secretion - - - - - Any process that modulates the frequency, rate or extent of the regulated release of glucagon. - GOC:BHF - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon. - down regulation of glucagon secretion - down-regulation of glucagon secretion - downregulation of glucagon secretion - inhibition of glucagon secretion - biological_process - GO:0070093 - negative regulation of glucagon secretion - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon. - GOC:BHF - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon. - up regulation of glucagon secretion - up-regulation of glucagon secretion - upregulation of glucagon secretion - activation of glucagon secretion - stimulation of glucagon secretion - biological_process - GO:0070094 - positive regulation of glucagon secretion - - - - - Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon. - GOC:BHF - GOC:mah - - - - - - - - - A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. - anchoring cell junction - cellular_component - GO:0070161 - anchoring junction - - - - - A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. - ISBN:0815332181 - - - - - anchoring cell junction - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - A process of chromosome organization that is involved in a meiotic cell cycle. - chromosome organisation involved in meiosis - meiotic chromosome organization - biological_process - GO:0070192 - chromosome organization involved in meiotic cell cycle - - - - - A process of chromosome organization that is involved in a meiotic cell cycle. - GOC:mah - - - - - chromosome organisation involved in meiosis - GOC:mah - - - - - meiotic chromosome organization - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a protein to a specific location on a chromosome. - establishment of protein localisation to chromosome - biological_process - GO:0070199 - establishment of protein localization to chromosome - - - - - The directed movement of a protein to a specific location on a chromosome. - GOC:BHF - GOC:mah - - - - - establishment of protein localisation to chromosome - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. - regulation of establishment of protein localisation - biological_process - GO:0070201 - regulation of establishment of protein localization - - - - - Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. - GOC:BHF - GOC:mah - - - - - regulation of establishment of protein localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome. - regulation of establishment of protein localisation to chromosome - biological_process - GO:0070202 - regulation of establishment of protein localization to chromosome - - - - - Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome. - GOC:BHF - GOC:mah - - - - - regulation of establishment of protein localisation to chromosome - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The regulated release of somatostatin from secretory granules in the D cells of the pancreas. - biological_process - GO:0070253 - somatostatin secretion - - - - - The regulated release of somatostatin from secretory granules in the D cells of the pancreas. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. - mucus production - biological_process - GO:0070254 - mucus secretion - - - - - The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. - GOC:add - ISBN:068340007X - ISBN:0721662544 - - - - - mucus production - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. - regulation of mucus production - biological_process - GO:0070255 - regulation of mucus secretion - - - - - Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. - GOC:add - - - - - regulation of mucus production - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. - negative regulation of mucus production - biological_process - GO:0070256 - negative regulation of mucus secretion - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. - GOC:add - - - - - negative regulation of mucus production - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. - positive regulation of mucus production - biological_process - GO:0070257 - positive regulation of mucus secretion - - - - - Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. - GOC:add - - - - - positive regulation of mucus production - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate. - biological_process - GO:0070285 - pigment cell development - - - - - The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate. - GOC:cvs - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat. - adipocyte proliferation - adipose cell proliferation - biological_process - GO:0070341 - fat cell proliferation - - - - - The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat. - GOC:mah - GOC:sl - - - - - adipocyte proliferation - GOC:sl - - - - - adipose cell proliferation - GOC:sl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of fat cell proliferation. - regulation of adipocyte proliferation - regulation of adipose cell proliferation - biological_process - GO:0070344 - regulation of fat cell proliferation - - - - - Any process that modulates the frequency, rate or extent of fat cell proliferation. - GOC:mah - GOC:sl - - - - - regulation of adipocyte proliferation - GOC:sl - - - - - regulation of adipose cell proliferation - GOC:sl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops or decreases the rate or extent of fat cell proliferation. - down regulation of fat cell proliferation - down-regulation of fat cell proliferation - downregulation of fat cell proliferation - negative regulation of adipocyte proliferation - negative regulation of adipose cell proliferation - inhibition of fat cell proliferation - biological_process - GO:0070345 - negative regulation of fat cell proliferation - - - - - Any process that stops or decreases the rate or extent of fat cell proliferation. - GOC:mah - GOC:sl - - - - - down regulation of fat cell proliferation - GOC:mah - - - - - down-regulation of fat cell proliferation - GOC:mah - - - - - downregulation of fat cell proliferation - GOC:mah - - - - - negative regulation of adipocyte proliferation - GOC:sl - - - - - negative regulation of adipose cell proliferation - GOC:sl - - - - - inhibition of fat cell proliferation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the rate or extent of fat cell proliferation. - positive regulation of adipocyte proliferation - positive regulation of adipose cell proliferation - up regulation of fat cell proliferation - up-regulation of fat cell proliferation - upregulation of fat cell proliferation - activation of fat cell proliferation - stimulation of fat cell proliferation - biological_process - GO:0070346 - positive regulation of fat cell proliferation - - - - - Any process that activates or increases the rate or extent of fat cell proliferation. - GOC:mah - GOC:sl - - - - - positive regulation of adipocyte proliferation - GOC:sl - - - - - positive regulation of adipose cell proliferation - GOC:sl - - - - - up regulation of fat cell proliferation - GOC:mah - - - - - up-regulation of fat cell proliferation - GOC:mah - - - - - upregulation of fat cell proliferation - GOC:mah - - - - - activation of fat cell proliferation - GOC:mah - - - - - stimulation of fat cell proliferation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver. - liver cell differentiation - biological_process - GO:0070365 - hepatocyte differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver. - CL:0000182 - PMID:7588884 - - - - - liver cell differentiation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of hepatocyte differentiation. - regulation of liver cell differentiation - biological_process - GO:0070366 - regulation of hepatocyte differentiation - - - - - Any process that modulates the frequency, rate or extent of hepatocyte differentiation. - GOC:mah - GOC:sl - - - - - regulation of liver cell differentiation - GOC:sl - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops or decreases the rate or extent of hepatocyte differentiation. - down regulation of hepatocyte differentiation - down-regulation of hepatocyte differentiation - downregulation of hepatocyte differentiation - negative regulation of liver cell differentiation - inhibition of hepatocyte differentiation - biological_process - GO:0070367 - negative regulation of hepatocyte differentiation - - - - - Any process that stops or decreases the rate or extent of hepatocyte differentiation. - GOC:mah - GOC:sl - - - - - down regulation of hepatocyte differentiation - GOC:mah - - - - - down-regulation of hepatocyte differentiation - GOC:mah - - - - - downregulation of hepatocyte differentiation - GOC:mah - - - - - negative regulation of liver cell differentiation - GOC:sl - - - - - inhibition of hepatocyte differentiation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the rate or extent of hepatocyte differentiation. - positive regulation of liver cell differentiation - up regulation of hepatocyte differentiation - up-regulation of hepatocyte differentiation - upregulation of hepatocyte differentiation - activation of hepatocyte differentiation - stimulation of hepatocyte differentiation - biological_process - GO:0070368 - positive regulation of hepatocyte differentiation - - - - - Any process that activates or increases the rate or extent of hepatocyte differentiation. - GOC:mah - GOC:sl - - - - - positive regulation of liver cell differentiation - GOC:sl - - - - - up regulation of hepatocyte differentiation - GOC:mah - - - - - up-regulation of hepatocyte differentiation - GOC:mah - - - - - upregulation of hepatocyte differentiation - GOC:mah - - - - - activation of hepatocyte differentiation - GOC:mah - - - - - stimulation of hepatocyte differentiation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. - exocytic constitutive secretory pathway transport vesicle - exocytotic vesicle - cellular_component - GO:0070382 - exocytic vesicle - - - - - A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. - GOC:kad - GOC:mah - - - - - exocytotic vesicle - GOC:kad - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. - biological_process - GO:0070482 - response to oxygen levels - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. - GOC:BHF - GOC:mah - - - - - - - - - - The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. - detection of reduced oxygen levels - biological_process - GO:0070483 - detection of hypoxia - - - - - The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. - GOC:BHF - GOC:mah - - - - - detection of reduced oxygen levels - GOC:vk - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. - regulation of microtubule cytoskeleton organisation - regulation of microtubule dynamics - biological_process - GO:0070507 - regulation of microtubule cytoskeleton organization - - - - - Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. - GOC:mah - - - - - regulation of microtubule cytoskeleton organisation - GOC:mah - - - - - regulation of microtubule dynamics - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a substance from one side of an epithelium to the other. - mah - 2009-05-06T03:31:02Z - biological_process - GO:0070633 - transepithelial transport - - - - - The directed movement of a substance from one side of an epithelium to the other. - GOC:mah - GOC:yaf - ISBN:0716731363 - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of ammonium ions from one side of an epithelium to the other. - mah - 2009-05-06T03:34:43Z - biological_process - GO:0070634 - transepithelial ammonium transport - - - - - The directed movement of ammonium ions from one side of an epithelium to the other. - GOC:mah - GOC:yaf - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The expansion of a leukocyte population by cell division. - mah - 2009-05-28T05:25:28Z - biological_process - GO:0070661 - leukocyte proliferation - - - - - The expansion of a leukocyte population by cell division. - GOC:add - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of leukocyte proliferation. - mah - 2009-05-28T05:30:39Z - biological_process - GO:0070663 - regulation of leukocyte proliferation - - - - - Any process that modulates the frequency, rate or extent of leukocyte proliferation. - GOC:add - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. - mah - 2009-05-28T05:34:50Z - down regulation of leukocyte proliferation - down-regulation of leukocyte proliferation - downregulation of leukocyte proliferation - inhibition of leukocyte proliferation - biological_process - GO:0070664 - negative regulation of leukocyte proliferation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. - GOC:add - GOC:mah - - - - - down regulation of leukocyte proliferation - GOC:mah - - - - - down-regulation of leukocyte proliferation - GOC:mah - - - - - downregulation of leukocyte proliferation - GOC:mah - - - - - inhibition of leukocyte proliferation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. - mah - 2009-05-28T05:36:46Z - up regulation of leukocyte proliferation - up-regulation of leukocyte proliferation - upregulation of leukocyte proliferation - activation of leukocyte proliferation - stimulation of leukocyte proliferation - biological_process - GO:0070665 - positive regulation of leukocyte proliferation - - - - - Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. - GOC:add - GOC:mah - - - - - up regulation of leukocyte proliferation - GOC:mah - - - - - up-regulation of leukocyte proliferation - GOC:mah - - - - - upregulation of leukocyte proliferation - GOC:mah - - - - - activation of leukocyte proliferation - GOC:mah - - - - - stimulation of leukocyte proliferation - GOC:mah - - - - - - - - - - Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. - mah - 2009-06-16T04:08:29Z - cellular macromolecule localisation - biological_process - GO:0070727 - cellular macromolecule localization - - - - - Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. - GOC:mah - - - - - cellular macromolecule localisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. - mah - 2009-07-23T05:01:51Z - biological_process - GO:0070831 - Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer. - basement membrane assembly - - - - - The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. - mah - 2009-08-14T03:09:02Z - regulation of bile acid anabolism - regulation of bile acid biosynthesis - regulation of bile acid formation - regulation of bile acid synthesis - biological_process - GO:0070857 - regulation of bile acid biosynthetic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. - GOC:BHF - GOC:mah - - - - - regulation of bile acid anabolism - GOC:mah - - - - - regulation of bile acid biosynthesis - GOC:mah - - - - - regulation of bile acid formation - GOC:mah - - - - - regulation of bile acid synthesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. - mah - 2009-08-14T03:16:40Z - down regulation of bile acid biosynthetic process - down-regulation of bile acid biosynthetic process - downregulation of bile acid biosynthetic process - negative regulation of bile acid anabolism - negative regulation of bile acid biosynthesis - negative regulation of bile acid formation - negative regulation of bile acid synthesis - inhibition of bile acid biosynthetic process - biological_process - GO:0070858 - negative regulation of bile acid biosynthetic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. - GOC:BHF - GOC:mah - - - - - down regulation of bile acid biosynthetic process - GOC:mah - - - - - down-regulation of bile acid biosynthetic process - GOC:mah - - - - - downregulation of bile acid biosynthetic process - GOC:mah - - - - - negative regulation of bile acid anabolism - GOC:mah - - - - - negative regulation of bile acid biosynthesis - GOC:mah - - - - - negative regulation of bile acid formation - GOC:mah - - - - - negative regulation of bile acid synthesis - GOC:mah - - - - - inhibition of bile acid biosynthetic process - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. - mah - 2009-08-14T03:22:58Z - positive regulation of bile acid anabolism - positive regulation of bile acid biosynthesis - positive regulation of bile acid formation - positive regulation of bile acid synthesis - up regulation of bile acid biosynthetic process - up-regulation of bile acid biosynthetic process - upregulation of bile acid biosynthetic process - activation of bile acid biosynthetic process - stimulation of bile acid biosynthetic process - biological_process - GO:0070859 - positive regulation of bile acid biosynthetic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. - GOC:BHF - GOC:mah - - - - - positive regulation of bile acid anabolism - GOC:mah - - - - - positive regulation of bile acid biosynthesis - GOC:mah - - - - - positive regulation of bile acid formation - GOC:mah - - - - - positive regulation of bile acid synthesis - GOC:mah - - - - - up regulation of bile acid biosynthetic process - GOC:mah - - - - - up-regulation of bile acid biosynthetic process - GOC:mah - - - - - upregulation of bile acid biosynthetic process - GOC:mah - - - - - activation of bile acid biosynthetic process - GOC:mah - - - - - stimulation of bile acid biosynthetic process - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. - mah - 2009-08-20T02:44:53Z - regulation of glycogen metabolism - biological_process - GO:0070873 - regulation of glycogen metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. - GOC:mah - - - - - regulation of glycogen metabolism - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen. - mah - 2009-08-20T02:50:41Z - negative regulation of glycogen metabolism - biological_process - GO:0070874 - negative regulation of glycogen metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen. - GOC:mah - - - - - negative regulation of glycogen metabolism - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. - mah - 2009-08-20T02:53:55Z - positive regulation of glycogen metabolism - biological_process - GO:0070875 - positive regulation of glycogen metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. - GOC:mah - - - - - positive regulation of glycogen metabolism - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. - mah - 2009-09-15T03:00:51Z - biological_process - GO:0070925 - - organelle assembly - - - - - The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. - mah - 2009-10-05T04:35:31Z - biological_process - GO:0070977 - bone maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. - GOC:dph - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. - mah - 2009-11-20T11:51:20Z - protein localisation to chromatin - biological_process - GO:0071168 - protein localization to chromatin - - - - - Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. - GOC:mah - - - - - protein localisation to chromatin - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a protein to a part of a chromosome that is organized into chromatin. - mah - 2009-11-20T11:52:43Z - establishment of protein localisation to chromatin - biological_process - GO:0071169 - establishment of protein localization to chromatin - - - - - The directed movement of a protein to a part of a chromosome that is organized into chromatin. - GOC:mah - - - - - establishment of protein localisation to chromatin - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. - mah - 2009-12-16T10:22:52Z - hemopoietic stem cell proliferation - biological_process - GO:0071425 - hematopoietic stem cell proliferation - - - - - The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. - CL:0000037 - GOC:BHF - GOC:add - GOC:mah - GOC:rl - - - - - - - - - The process of biting and mashing food with the teeth prior to swallowing. - mah - 2010-02-10T11:19:48Z - chewing - biological_process - GO:0071626 - mastication - - - - - The process of biting and mashing food with the teeth prior to swallowing. - GOC:gvg - - - - - chewing - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location. - mah - 2010-02-25T04:00:13Z - protein localisation in extracellular region - protein localization in extracellular region - biological_process - GO:0071692 - protein localization to extracellular region - - - - - Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location. - GOC:mah - - - - - protein localisation in extracellular region - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. - mah - 2010-03-02T11:43:38Z - biological_process - GO:0071695 - anatomical structure maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. - mah - 2010-03-02T11:48:01Z - biological_process - GO:0071696 - ectodermal placode development - - - - - The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. - mah - 2010-03-02T11:49:51Z - biological_process - GO:0071697 - ectodermal placode morphogenesis - - - - - The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. - mah - 2010-03-08T02:15:14Z - biological_process - GO:0071702 - organic substance transport - - - - - The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. - mah - 2010-03-08T03:32:18Z - organic molecular entity metabolic process - organic molecular entity metabolism - organic substance metabolism - biological_process - GO:0071704 - organic substance metabolic process - - - - - The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - mah - 2010-03-08T03:56:28Z - biological_process - GO:0071705 - nitrogen compound transport - - - - - The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of a set of components to form a membrane. - mah - 2010-03-10T11:19:17Z - biological_process - GO:0071709 - membrane assembly - - - - - The aggregation, arrangement and bonding together of a set of components to form a membrane. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. - mah - 2010-03-10T11:57:10Z - basement membrane organisation - biological_process - GO:0071711 - Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer. - basement membrane organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. - GOC:mah - - - - - basement membrane organisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane. - mah - 2010-03-29T03:59:35Z - nuclear membrane organisation - biological_process - nuclear membrane organization and biogenesis - GO:0071763 - nuclear membrane organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane. - GOC:mah - - - - - nuclear membrane organisation - GOC:mah - - - - - nuclear membrane organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane. - mah - 2010-03-29T04:03:37Z - nuclear outer membrane organisation - biological_process - nuclear outer membrane organization and biogenesis - GO:0071764 - nuclear outer membrane organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane. - GOC:mah - - - - - nuclear outer membrane organisation - GOC:mah - - - - - nuclear outer membrane organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a protein is transported across a membrane. - mah - 2010-09-03T02:54:26Z - protein membrane transport - biological_process - GO:0071806 - Note that this term is not intended for use in annotating lateral movement within membranes. - protein transmembrane transport - - - - - The process in which a protein is transported across a membrane. - GOC:mah - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. - mah - 2010-09-08T10:03:26Z - DNA-protein complex subunit organization - protein-DNA complex subunit organisation - protein-DNA complex subunit organization - biological_process - GO:0071824 - protein-DNA complex organization - - - - - Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. - GOC:mah - - - - - DNA-protein complex subunit organization - GOC:mah - - - - - protein-DNA complex subunit organisation - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. - https://github.com/geneontology/go-ontology/issues/25143 - mah - 2010-09-08T10:10:35Z - RNA-protein complex subunit organization - protein-RNA complex subunit organization - ribonucleoprotein complex subunit organisation - ribonucleoprotein complex subunit organization - biological_process - GO:0071826 - protein-RNA complex organization - - - - - Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. - GOC:mah - - - - - RNA-protein complex subunit organization - GOC:mah - - - - - protein-RNA complex subunit organization - GOC:mah - - - - - ribonucleoprotein complex subunit organisation - GOC:mah - - - - - - - - - A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. - mah - 2010-09-10T01:39:16Z - GO:0071841 - cellular component organisation or biogenesis - cellular component organisation or biogenesis at cellular level - cellular component organization or biogenesis at cellular level - biological_process - GO:0071840 - - - cellular component organization or biogenesis - - - - - A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. - GOC:mah - - - - - cellular component organisation or biogenesis - GOC:mah - - - - - cellular component organisation or biogenesis at cellular level - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan. - mah - 2010-09-13T02:36:37Z - response to monoamine stimulus - biological_process - GO:0071867 - response to monoamine - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan. - GOC:mah - - - - - response to monoamine stimulus - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. - mah - 2010-09-13T02:51:13Z - response to catecholamine stimulus - biological_process - GO:0071869 - response to catecholamine - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. - GOC:BHF - GOC:mah - - - - - response to catecholamine stimulus - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system. - mah - 2010-09-13T03:31:53Z - response to noradrenaline stimulus - response to norepinephrine stimulus - biological_process - GO:0071873 - Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. - response to norepinephrine - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system. - GOC:BHF - GOC:mah - - - - - response to noradrenaline stimulus - GOC:mah - - - - - response to norepinephrine stimulus - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. - mah - 2010-09-14T12:44:09Z - leukocyte apoptosis - biological_process - GO:0071887 - Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). - leukocyte apoptotic process - - - - - Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. - CL:0000738 - GOC:BHF - GOC:mah - GOC:mtg_apoptosis - - - - - - - - - - - - - - - - - - - - - - - - - - - - The biosynthetic process resulting in the formation of DNA. - mah - 2010-09-15T02:14:33Z - DNA anabolism - DNA biosynthesis - DNA formation - DNA synthesis - biological_process - GO:0071897 - DNA biosynthetic process - - - - - The biosynthetic process resulting in the formation of DNA. - GOC:mah - - - - - DNA anabolism - GOC:mah - - - - - DNA biosynthesis - GOC:mah - - - - - DNA formation - GOC:mah - - - - - DNA synthesis - GOC:mah - - - - - - - - - The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. - mah - 2010-10-04T01:51:47Z - cellular_component - GO:0071944 - - cell periphery - - - - - The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. - GOC:pdt - - - - - - - - - - - - - - - An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. - mah - 2010-10-11T11:44:57Z - elastic fibre - elastin fiber - cellular_component - GO:0071953 - elastic fiber - - - - - An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. - GOC:BHF - GOC:mah - PMID:20236620 - - - - - elastic fibre - GOC:mah - - - - - elastin fiber - GOC:BHF - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm. - mah - 2010-10-18T03:44:18Z - extracellular vesicular exosome assembly - biological_process - GO:0071971 - extracellular exosome assembly - - - - - The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm. - GOC:mah - GOC:tfm - PMID:19442504 - PMID:27462458 - - - - - extracellular vesicular exosome assembly - GOC:vesicles - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels. - mah - 2010-01-25T10:31:00Z - urinary system development - urinary tract development - biological_process - GO:0072001 - - renal system development - - - - - The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels. - GOC:mtg_kidney_jan10 - GOC:yaf - http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System - - - - - urinary system development - GOC:yaf - - - - - urinary tract development - GOC:yaf - PMID:17881463 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. - mah - 2010-02-08T02:03:36Z - biological_process - GO:0072089 - stem cell proliferation - - - - - The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. - GOC:mtg_kidney_jan10 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. - mah - 2010-02-08T02:09:03Z - biological_process - GO:0072091 - regulation of stem cell proliferation - - - - - Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. - GOC:mtg_kidney_jan10 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. - mah - 2010-02-22T02:17:15Z - biological_process - GO:0072132 - mesenchyme morphogenesis - - - - - The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. - GOC:mtg_kidney_jan10 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of an epithelial tube. - https://github.com/geneontology/go-ontology/issues/22302 - mah - 2010-02-26T02:15:40Z - biological_process - GO:0072175 - epithelial tube formation - - - - - The developmental process pertaining to the initial formation of an epithelial tube. - GOC:mtg_kidney_jan10 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. - mah - 2010-03-01T03:43:29Z - biological_process - GO:0072201 - negative regulation of mesenchymal cell proliferation - - - - - Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. - GOC:mtg_kidney_jan10 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. - mah - 2010-11-02T04:41:55Z - biological_process - GO:0072329 - monocarboxylic acid catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. - mah - 2010-11-02T04:51:32Z - monocarboxylic acid anabolism - monocarboxylic acid biosynthesis - monocarboxylic acid formation - monocarboxylic acid synthesis - biological_process - GO:0072330 - monocarboxylic acid biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. - GOC:mah - - - - - monocarboxylic acid anabolism - GOC:mah - - - - - monocarboxylic acid biosynthesis - GOC:mah - - - - - monocarboxylic acid formation - GOC:mah - - - - - monocarboxylic acid synthesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - mah - 2010-11-11T11:43:56Z - sulfur-containing compound transport - biological_process - GO:0072348 - sulfur compound transport - - - - - The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:mah - - - - - sulfur-containing compound transport - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. - mah - 2010-11-16T11:27:39Z - GO:0072358 - cardiovascular system development - biological_process - GO:0072359 - - circulatory system development - - - - - The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. - GOC:mah - UBERON:0001009 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis. - mah - 2010-11-16T11:46:55Z - biological_process - GO:0072360 - vascular cord development - - - - - The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis. - GOC:mah - PMID:7084422 - ZFA:0005077 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. - mah - 2010-12-01T04:59:11Z - microtubule-based organelle localization - biological_process - GO:0072384 - organelle transport along microtubule - - - - - The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. - GOC:mah - - - - - microtubule-based organelle localization - GOC:rl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+. - https://github.com/geneontology/go-ontology/issues/22228 - mah - 2010-12-10T10:29:57Z - GO:0015696 - ammonia transport - ammonium transport - ammonium membrane transport - biological_process - GO:0072488 - Note that this term is not intended for use in annotating lateral movement within membranes. - ammonium transmembrane transport - - - - - The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. - mah - 2011-01-27T01:57:14Z - pancreatic B cell maturation - pancreatic beta cell maturation - biological_process - GO:0072560 - These processes continue to 60 DPA in Gossypium spp. - type B pancreatic cell maturation - - - - - A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. - CL:0000169 - GOC:BHF - - - - - pancreatic B cell maturation - CL:0000169 - GOC:mah - - - - - pancreatic beta cell maturation - CL:0000169 - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver. - mah - 2011-02-02T03:37:50Z - biological_process - GO:0072575 - epithelial cell proliferation involved in liver morphogenesis - - - - - The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver. - GOC:BHF - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of the liver are generated and organized. - mah - 2011-02-02T03:41:30Z - biological_process - GO:0072576 - liver morphogenesis - - - - - The process in which the anatomical structures of the liver are generated and organized. - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. - mah - 2011-02-02T03:56:24Z - apoptosis of endothelial cells - endothelial cell programmed cell death by apoptosis - killing of endothelial cells - programmed cell death of endothelial cells by apoptosis - programmed cell death, endothelial cells - endothelial cell apoptosis - biological_process - GO:0072577 - endothelial cell apoptotic process - - - - - Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. - CL:0000115 - GOC:BHF - GOC:mah - GOC:mtg_apoptosis - - - - - apoptosis of endothelial cells - GOC:mah - - - - - endothelial cell programmed cell death by apoptosis - GOC:mah - - - - - killing of endothelial cells - GOC:mah - - - - - programmed cell death of endothelial cells by apoptosis - GOC:mah - - - - - programmed cell death, endothelial cells - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving diatomic oxygen (O2). - mah - 2011-02-11T10:46:51Z - diatomic oxygen metabolic process - oxygen metabolism - biological_process - GO:0072592 - oxygen metabolic process - - - - - The chemical reactions and pathways involving diatomic oxygen (O2). - GOC:mah - - - - - diatomic oxygen metabolic process - CHEBI:33263 - - - - - oxygen metabolism - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. - mah - 2011-02-14T01:56:51Z - establishment of protein localisation to organelle - biological_process - GO:0072594 - establishment of protein localization to organelle - - - - - The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. - GOC:mah - - - - - establishment of protein localisation to organelle - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, a specific location in a membrane. - mah - 2011-02-14T02:35:18Z - protein localisation in membrane - protein localization in membrane - biological_process - GO:0072657 - - protein localization to membrane - - - - - A process in which a protein is transported to, or maintained in, a specific location in a membrane. - GOC:mah - - - - - protein localisation in membrane - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. - tb - 2009-07-10T10:29:23Z - GO:0072661 - GO:0090002 - biological_process - protein localisation in plasma membrane - protein localization in plasma membrane - protein targeting to plasma membrane - protein-plasma membrane targeting - GO:0072659 - - - protein localization to plasma membrane - - - - - A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. - GOC:mah - - - - - protein localisation in plasma membrane - GOC:mah - - - - - protein-plasma membrane targeting - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained at, a location in a vacuole. - mah - 2011-02-14T02:55:35Z - protein localisation to vacuole - biological_process - GO:0072665 - protein localization to vacuole - - - - - A process in which a protein is transported to, or maintained at, a location in a vacuole. - GOC:ecd - - - - - protein localisation to vacuole - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a protein to a specific location in a vacuole. - mah - 2011-02-14T02:56:29Z - establishment of protein localisation to vacuole - biological_process - GO:0072666 - establishment of protein localization to vacuole - - - - - The directed movement of a protein to a specific location in a vacuole. - GOC:mah - - - - - establishment of protein localisation to vacuole - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, the cell cortex. - mah - 2012-04-11T01:16:33Z - protein localisation to cell cortex - biological_process - GO:0072697 - protein localization to cell cortex - - - - - A process in which a protein is transported to, or maintained in, the cell cortex. - GOC:mah - - - - - protein localisation to cell cortex - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton. - mah - 2012-04-11T01:19:35Z - protein localisation to microtubule cytoskeleton - biological_process - GO:0072698 - protein localization to microtubule cytoskeleton - - - - - A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton. - GOC:mah - - - - - protein localisation to microtubule cytoskeleton - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. - dhl - 2009-04-22T04:30:52Z - biological_process - GO:0080090 - regulation of primary metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. - PMID:19211694 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). - dhl - 2009-05-06T04:51:28Z - biological_process - GO:0080134 - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - regulation of response to stress - - - - - Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). - GOC:dhl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). - dhl - 2010-09-01T03:44:27Z - biological_process - GO:0080154 - regulation of fertilization - - - - - Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). - GOC:DHL - PMID:20478994 - - - - - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of the extracellular matrix. - jl - 2010-07-14T12:52:49Z - biological_process - GO:0085029 - extracellular matrix assembly - - - - - The aggregation, arrangement and bonding together of the extracellular matrix. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - An action potential that occurs in a cardiac muscle cell. - tb - 2011-11-10T07:45:11Z - biological_process - GO:0086001 - cardiac muscle cell action potential - - - - - An action potential that occurs in a cardiac muscle cell. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An action potential that occurs in a sinoatrial node cardiac muscle cell. - tb - 2011-11-10T08:50:15Z - SA node cardiac muscle cell action potential - SAN cardiac muscle cell action potential - sinoatrial node cardiac muscle cell action potential - sinus node cardiac muscle cell action potential - biological_process - GO:0086015 - SA node cell action potential - - - - - An action potential that occurs in a sinoatrial node cardiac muscle cell. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An action potential that occurs in an atrioventricular node cardiac muscle cell. - tb - 2011-11-10T08:58:56Z - AV node cardiac muscle cell action potential - atrioventricular node cardiac muscle cell action potential - biological_process - GO:0086016 - AV node cell action potential - - - - - An action potential that occurs in an atrioventricular node cardiac muscle cell. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An action potential that occurs in a Purkinje myocyte. - tb - 2011-11-10T08:58:56Z - biological_process - GO:0086017 - Purkinje myocyte action potential - - - - - An action potential that occurs in a Purkinje myocyte. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - - - - - - Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte. - tb - 2011-11-10T09:15:01Z - SA node cardiac muscle cell to atrial cardiac muscle cell signalling - SA node cardiomyocyte to atrial cardiomyocyte signalling - SAN cardiomyocyte to atrial cardiomyocyte signalling - sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling - sinus node cardiomyocyte to atrial cardiomyocyte signalling - biological_process - GO:0086018 - SA node cell to atrial cardiac muscle cell signaling - - - - - Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. - dph - 2011-11-16T03:43:52Z - cell-cell signalling involved in cardiac conduction - biological_process - GO:0086019 - cell-cell signaling involved in cardiac conduction - - - - - Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - cell-cell signalling involved in cardiac conduction - GOC:mah - - - - - - - - - - Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte. - tb - 2011-11-11T02:02:14Z - AV node cell to bundle of His cell signalling - atrioventricular node to bundle of His cell signaling - biological_process - GO:0086027 - AV node cell to bundle of His cell signaling - - - - - Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - AV node cell to bundle of His cell signalling - GOC:mah - - - - - - - - - - Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell. - tb - 2011-11-11T02:02:14Z - Purkinje myocyte to ventricular cardiac muscle cell signalling - biological_process - GO:0086029 - Purkinje myocyte to ventricular cardiac muscle cell signaling - - - - - Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - Purkinje myocyte to ventricular cardiac muscle cell signalling - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - dph - 2011-11-22T08:57:02Z - biological_process - GO:0086065 - cell communication involved in cardiac conduction - - - - - Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - - - - - The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - dph - 2011-11-22T09:11:44Z - atrioventricular node cell to bundle of His cell communication - biological_process - GO:0086067 - AV node cell to bundle of His cell communication - - - - - The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - - - - - The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - dph - 2011-11-22T09:14:49Z - biological_process - GO:0086068 - Purkinje myocyte to ventricular cardiac muscle cell communication - - - - - The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - - - - - The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - dph - 2011-11-22T09:32:45Z - SA node cardiac muscle cell to atrial cardiac muscle cell communication - SA node cardiomyocyte to atrial cardiomyocyte communication - SAN cardiomyocyte to atrial cardiomyocyte communication - sinoatrial node cardiomyocyte to atrial cardiomyocyte communication - sinus node cardiomyocyte to atrial cardiomyocyte communication - biological_process - GO:0086070 - SA node cell to atrial cardiac muscle cell communication - - - - - The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. - tb - 2009-08-12T11:33:09Z - biological_process - GO:0090063 - positive regulation of microtubule nucleation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. - tb - 2009-09-09T11:39:52Z - biological_process - GO:0090068 - positive regulation of cell cycle process - - - - - Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. - tb - 2009-09-11T10:32:17Z - biological_process - GO:0090069 - regulation of ribosome biogenesis - - - - - Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. - tb - 2009-09-11T10:32:17Z - biological_process - GO:0090070 - positive regulation of ribosome biogenesis - - - - - Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. - tb - 2009-09-11T10:32:17Z - biological_process - GO:0090071 - negative regulation of ribosome biogenesis - - - - - Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - tb - 2009-10-23T11:21:38Z - biological_process - GO:0090087 - regulation of peptide transport - - - - - Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. - tb - 2009-11-04T10:03:25Z - biological_process - GO:0090091 - positive regulation of extracellular matrix disassembly - - - - - Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a protein to a specific location in a membrane. - tb - 2009-12-08T03:18:51Z - establishment of protein localisation in membrane - establishment of protein localization in membrane - biological_process - GO:0090150 - establishment of protein localization to membrane - - - - - The directed movement of a protein to a specific location in a membrane. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - establishment of protein localisation in membrane - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The specification and formation of anisotropic intracellular organization of an epithelial cell. - tb - 2009-12-08T08:58:27Z - biological_process - GO:0090162 - establishment of epithelial cell polarity - - - - - The specification and formation of anisotropic intracellular organization of an epithelial cell. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance. - tb - 2009-12-08T09:15:11Z - Golgi apparatus disassembly - biological_process - GO:0090166 - Golgi disassembly - - - - - A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance. - tb - 2009-12-08T09:15:11Z - Golgi apparatus reassembly - biological_process - GO:0090168 - Golgi reassembly - - - - - The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division. - tb - 2009-12-11T10:21:59Z - biological_process - GO:0090170 - regulation of Golgi inheritance - - - - - Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte. - tb - 2009-12-11T10:36:02Z - biological_process - GO:0090171 - chondrocyte morphogenesis - - - - - The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - The joining of two lipid bilayers to form a single organelle membrane. - tb - 2009-12-11T11:44:58Z - biological_process - GO:0090174 - organelle membrane fusion - - - - - The joining of two lipid bilayers to form a single organelle membrane. - GOC:ascb_2009 - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. - tb - 2010-02-03T11:48:13Z - biological_process - GO:0090257 - regulation of muscle system process - - - - - Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. - tb - 2010-02-05T02:54:14Z - biological_process - GO:0090273 - regulation of somatostatin secretion - - - - - Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. - GOC:BHF - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. - tb - 2010-02-05T02:54:14Z - biological_process - GO:0090274 - positive regulation of somatostatin secretion - - - - - Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. - GOC:BHF - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. - tb - 2010-02-05T02:54:14Z - biological_process - GO:0090275 - negative regulation of somatostatin secretion - - - - - Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. - GOC:BHF - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. - tb - 2010-02-05T02:56:39Z - biological_process - GO:0090276 - regulation of peptide hormone secretion - - - - - Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. - tb - 2010-02-05T02:56:39Z - biological_process - GO:0090277 - positive regulation of peptide hormone secretion - - - - - Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. - tb - 2010-02-05T02:56:39Z - biological_process - GO:0090278 - negative regulation of peptide hormone secretion - - - - - Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. - tb - 2010-03-12T04:08:26Z - biological_process - GO:0090299 - regulation of neural crest formation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. - tb - 2010-03-12T04:08:26Z - biological_process - GO:0090300 - positive regulation of neural crest formation - - - - - Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. - tb - 2010-03-12T04:08:26Z - biological_process - GO:0090301 - negative regulation of neural crest formation - - - - - Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any cellular metabolic process involving nucleic acids. - tb - 2010-04-07T10:18:47Z - biological_process - GO:0090304 - nucleic acid metabolic process - - - - - Any cellular metabolic process involving nucleic acids. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. - tb - 2010-04-16T03:45:07Z - biological_process - GO:0090316 - positive regulation of intracellular protein transport - - - - - Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. - tb - 2010-04-16T03:45:07Z - biological_process - GO:0090317 - negative regulation of intracellular protein transport - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. - tb - 2010-05-14T10:24:29Z - biological_process - GO:0090325 - regulation of locomotion involved in locomotory behavior - - - - - Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. - GOC:dph - GOC:kmv - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. - tb - 2010-05-14T10:26:58Z - biological_process - GO:0090326 - positive regulation of locomotion involved in locomotory behavior - - - - - Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. - GOC:dph - GOC:kmv - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. - tb - 2010-05-14T10:26:58Z - biological_process - GO:0090327 - negative regulation of locomotion involved in locomotory behavior - - - - - Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. - GOC:dph - GOC:kmv - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini. - tb - 2012-05-04T09:24:48Z - biological_process - GO:0090425 - acinar cell differentiation - - - - - The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained at, a location within a nuclear envelope. - tb - 2012-07-30T01:50:41Z - protein localization in nuclear envelope - biological_process - GO:0090435 - protein localization to nuclear envelope - - - - - A process in which a protein is transported to, or maintained at, a location within a nuclear envelope. - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of catecholamine into a cell. - tb - 2012-10-17T11:06:17Z - biological_process - GO:0090493 - catecholamine uptake - - - - - The directed movement of catecholamine into a cell. - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. - tb - 2014-08-22T13:23:20Z - biological_process - GO:0090596 - sensory organ morphogenesis - - - - - Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. - GOC:kmv - ISBN:978-0199210893 - - - - - - - - - - - - - - - - - - - - - - - - - - A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus. - tb - 2016-07-19T17:00:49Z - RNA localisation to nucleus - biological_process - GO:0090685 - RNA localization to nucleus - - - - - A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus. - GOC:mah - PMID:26305931 - - - - - RNA localisation to nucleus - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any membrane that is part of a pigment granule. - tb - 2017-05-16T22:33:39Z - cellular_component - GO:0090741 - pigment granule membrane - - - - - Any membrane that is part of a pigment granule. - PMID:11294610 - - - - - - - - - - - - - - - - - - - - - - - - - - All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. - pr - 2011-03-23T01:52:31Z - cilium plasm - microtubule-based flagellar matrix - microtubule-based flagellum matrix - cellular_component - cilial cytoplasm - ciliary cytoplasm - cilium cytoplasm - microtubule-based flagellar cytoplasm - microtubule-based flagellum cytoplasm - GO:0097014 - Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm". - ciliary plasm - - - - - All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. - GOC:BHF - GOC:cilia - GOC:dos - PMID:17895364 - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. - pr - 2011-05-04T02:21:43Z - motoneuron apoptosis - motor neuron apoptosis - biological_process - GO:0097049 - motor neuron apoptotic process - - - - - Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. - CL:0000100 - GOC:BHF - GOC:mtg_apoptosis - PMID:14523086 - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin. - pr - 2011-05-04T02:24:38Z - pancreatic B cell apoptosis - pancreatic beta cell apoptosis - type B pancreatic cell apoptosis - biological_process - GO:0097050 - type B pancreatic cell apoptotic process - - - - - Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin. - CL:0000169 - GOC:BHF - GOC:mtg_apoptosis - PMID:16087305 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. - pr - 2011-06-07T11:22:09Z - cellular_component - GO:0097060 - - synaptic membrane - - - - - A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. - GOC:BHF - PMID:20410104 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. - pr - 2011-06-20T04:03:08Z - vascular smooth muscle cell development - biological_process - GO:0097084 - vascular associated smooth muscle cell development - - - - - The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. - GOC:BHF - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. - pr - 2011-09-06T02:31:59Z - mesenchymal cell apoptosis - biological_process - GO:0097152 - mesenchymal cell apoptotic process - - - - - Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. - CL:0000134 - GOC:mtg_apoptosis - GOC:yaf - PMID:18231833 - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving the ammonium ion. - pr - 2011-09-28T04:21:30Z - ammonium ion metabolism - biological_process - ammonium metabolic process - GO:0097164 - ammonium ion metabolic process - - - - - The chemical reactions and pathways involving the ammonium ion. - GOC:dhl - GOC:tb - PMID:14671018 - - - - - - - - - - - - - - - The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. - pr - 2011-11-23T09:30:23Z - GO:0008624 - apoptotic signalling pathway - induction of apoptosis by extracellular signals - biological_process - GO:0097190 - This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways. - apoptotic signaling pathway - - - - - The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. - GOC:mtg_apoptosis - - - - - apoptotic signalling pathway - GOC:mah - - - - - - - - - - - - - - - - - - - - - A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. - pr - 2011-11-23T09:45:24Z - execution phase of apoptotic process - apoptosis - biological_process - GO:0097194 - execution phase of apoptosis - - - - - A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. - GOC:mtg_apoptosis - PMID:21760595 - - - - - - - - Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. - pr - 2012-02-02T12:23:31Z - biological_process - GO:0097237 - cellular response to toxic substance - - - - - Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. - GOC:pr - - - - - - - - - - The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. - https://github.com/geneontology/go-ontology/issues/22368 - pr - 2012-03-05T02:03:58Z - biological_process - GO:0097254 - renal tubular secretion - - - - - The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. - GOC:rph - PMID:25287933 - Wikipedia:Renal_secretion#Secretion - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in a hepatocyte, the main structural component of the liver. - pr - 2012-03-29T10:23:21Z - hepatocyte apoptosis - biological_process - GO:0097284 - hepatocyte apoptotic process - - - - - Any apoptotic process in a hepatocyte, the main structural component of the liver. - CL:0000182 - GOC:jc - GOC:mtg_apoptosis - PMID:15856020 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin. - pr - 2012-07-03T03:19:07Z - protein localisation to heterochromatin - biological_process - GO:0097355 - protein localization to heterochromatin - - - - - Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin. - GOC:mah - - - - - protein localisation to heterochromatin - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - A prolongation or process extending from a glial cell. - pr - 2012-10-22T13:55:54Z - cellular_component - glial process - glial projection - GO:0097386 - glial cell projection - - - - - A prolongation or process extending from a glial cell. - GOC:mc - - - - - - - - - - - - - - - - - - - - - An arrangement of closely apposed microtubules running parallel to each other. - pr - 2012-11-07T15:01:27Z - NIF_Subcellular:sao1872343973 - microtubule fascicle - cellular_component - GO:0097427 - microtubule bundle - - - - - An arrangement of closely apposed microtubules running parallel to each other. - NIF_Subcellular:sao1872343973 - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. - pr - 2012-11-27T15:46:25Z - GO:0043206 - extracellular fibril organisation - extracellular fibril organization - extracellular fibril organization and biogenesis - biological_process - fibril organisation - fibril organization - GO:0097435 - supramolecular fiber organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. - GOC:pr - - - - - extracellular fibril organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina. - pr - 2013-03-21T09:44:45Z - rod photoreceptor apoptotic process - biological_process - GO:0097473 - retinal rod cell apoptotic process - - - - - Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina. - CL:0000604 - GOC:jc - PMID:17202487 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina. - pr - 2013-03-21T09:46:22Z - cone photoreceptor apoptotic process - biological_process - GO:0097474 - retinal cone cell apoptotic process - - - - - Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina. - CL:0000573 - GOC:jc - - - - - - - - - - - - - - - - - - - - - - - - - - A cardiac myofibril is a myofibril specific to cardiac muscle cells. - pr - 2013-10-16T13:04:58Z - cellular_component - GO:0097512 - cardiac myofibril - - - - - A cardiac myofibril is a myofibril specific to cardiac muscle cells. - GOC:cjm - GOC:devbiol - - - - - - - - - - - - - - - - - - - - - - - - - - - Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. - pr - 2014-02-28T09:49:31Z - biological_process - GO:0097576 - vacuole fusion - - - - - Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. - GOC:pr - GOC:vw - Wikipedia:Vacuole - - - - - - - - - - - - - - - - - - - - - - - - - - - Any vesicle that is part of the intracellular region. - pr - 2016-03-29T17:39:45Z - cellular_component - GO:0097708 - intracellular vesicle - - - - - Any vesicle that is part of the intracellular region. - GOC:vesicles - - - - - - - - - - - - - - - The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane. - pr - 2016-08-05T16:12:33Z - Reactome:R-HSA-5620912.1 - ciliary basal body docking - biological_process - anchoring of the basal body to the plasma membrane - GO:0097711 - Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella. - ciliary basal body-plasma membrane docking - - - - - The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane. - GOC:cilia - PMID:13978319 - PMID:23348840 - PMID:23530209 - PMID:25686250 - PMID:26981235 - Reactome:R-HSA-5620912.1 - - - - - - - - - - - - - - - The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces. - pr - 2016-08-05T16:16:28Z - biological_process - GO:0097712 - vesicle targeting, trans-Golgi to periciliary membrane compartment - - - - - The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces. - GOC:cilia - PMID:20106869 - PMID:23351793 - PMID:24814148 - PMID:26485645 - Reactome:R-HSA-5620920.1 - - - - - - - - - The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. - pr - 2016-10-03T14:35:25Z - exosome assembly or secretion - exosome biogenesis - exosome production - biological_process - ILV assembly - intraluminal vesicle assembly - GO:0097734 - extracellular exosome biogenesis - - - - - The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. - GOC:PARL - GOC:bf - PMID:19442504 - PMID:25392495 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A neuromuscular junction in which the target muscle cell is a myotube. - dos - 2013-10-14T12:05:12Z - cellular_component - GO:0098523 - In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting the myotubes of skeletal muscle (AKA skeletal muscle fibers). Neuromuscular junctions targeting other muscle cell types exist in invertebrates such as the mononucleate somatic muscles of nematodes. - neuromuscular junction of myotube - - - - - A neuromuscular junction in which the target muscle cell is a myotube. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract. - dos - 2013-10-15T14:00:34Z - biological_process - GO:0098528 - skeletal muscle fiber differentiation - - - - - The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - The lipid bilayer that forms the outer-most layer of an organelle. - dos - 2014-02-26T13:41:31Z - cellular_component - GO:0098588 - Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes. - bounding membrane of organelle - - - - - The lipid bilayer that forms the outer-most layer of an organelle. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - A membrane that is a (regional) part of the plasma membrane. - dos - 2014-03-06T11:55:32Z - region of plasma membrane - cellular_component - GO:0098590 - - Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. - plasma membrane region - - - - - A membrane that is a (regional) part of the plasma membrane. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A collagen trimer that forms networks. - cellular_component - GO:0098642 - network-forming collagen trimer - - - - - A collagen trimer that forms networks. - PMID:21421911 - - - - - - - - - - - - - - - - - - - - - - A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). - cellular_component - GO:0098643 - banded collagen fibril - - - - - A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). - GOC:dos - PMID:21421911 - - - - - - - - - - - - - - - - - - - - - - A complex of collagen trimers such as a fibril or collagen network. - Supramolecular aggregate of collagen - Supramolecular collagen assembly - cellular_component - GO:0098644 - complex of collagen trimers - - - - - A complex of collagen trimers such as a fibril or collagen network. - GOC:dos - - - - - Supramolecular aggregate of collagen - PMID:19693541 - - - - - Supramolecular collagen assembly - PMID:21421911 - - - - - - - - - - - - - - - - A supramolecular complex that consists of collagen triple helices associated to form a network. - cellular_component - GO:0098645 - collagen network - - - - - A supramolecular complex that consists of collagen triple helices associated to form a network. - GOC:dos - PMID:21421911 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any collagen timer that is part of a basement membrane. - cellular_component - GO:0098651 - basement membrane collagen trimer - - - - - Any collagen timer that is part of a basement membrane. - GOC:dos - PMID:21421911 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. - GO:0099132 - cation transmembrane transport - ATP hydrolysis coupled cation transmembrane transport - biological_process - GO:0098655 - monoatomic cation transmembrane transport - - - - - The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. - GOC:dos - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. - uptake - biological_process - GO:0098657 - import into cell - - - - - The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which an inorganic ion is transported across a membrane. - inorganic ion membrane transport - transmembrane inorganic ion transport - biological_process - GO:0098660 - Note that this term is not intended for use in annotating lateral movement within membranes. - inorganic ion transmembrane transport - - - - - The process in which an inorganic ion is transported across a membrane. - GOC:mah - - - - - transmembrane inorganic ion transport - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which an inorganic anion is transported across a membrane. - inorganic anion membrane transport - transmembrane inorganic anion transport - biological_process - GO:0098661 - Note that this term is not intended for use in annotating lateral movement within membranes. - inorganic anion transmembrane transport - - - - - The process in which an inorganic anion is transported across a membrane. - GOC:mah - - - - - transmembrane inorganic anion transport - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. - GO:0015672 - GO:0072511 - inorganic cation membrane transport - transmembrane inorganic cation transport - divalent inorganic cation transport - monovalent inorganic cation transport - biological_process - GO:0098662 - Note that this term is not intended for use in annotating lateral movement within membranes. - inorganic cation transmembrane transport - - - - - A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. - GOC:mah - - - - - transmembrane inorganic cation transport - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity. - biological_process - GO:0098722 - asymmetric stem cell division - - - - - Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity. - GOC:dos - PMID:18513950 - - - - - - - - - - - - - - - - - - - - - - - - - - A myofibril of a skeletal muscle fiber. - cellular_component - GO:0098723 - skeletal muscle myofibril - - - - - A myofibril of a skeletal muscle fiber. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes. - biological_process - GO:0098728 - germline stem cell asymmetric division - - - - - The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. - biological_process - GO:0098751 - - Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development. - bone cell development - - - - - The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. - GOC:dos - - - - - - - - - - - - - - - Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. - biological_process - GO:0098754 - - - - detoxification - - - - - Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. - biological_process - GO:0098773 - skin epidermis development - - - - - The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. - GOC:dos - - - - - - - - - - - - - - - - - - - - - The part of a synapse that is part of the presynaptic cell. - presynaptic terminal - cellular_component - GO:0098793 - - presynapse - - - - - The part of a synapse that is part of the presynaptic cell. - GOC:dos - - - - - - - - - - - - - - - - - - - - - The part of a synapse that is part of the post-synaptic cell. - cellular_component - GO:0098794 - - postsynapse - - - - - The part of a synapse that is part of the post-synaptic cell. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - Any protein complex that is part of a membrane. - cellular_component - GO:0098796 - - membrane protein complex - - - - - Any protein complex that is part of a membrane. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - Any protein complex that is part of the plasma membrane. - cellular_component - GO:0098797 - plasma membrane protein complex - - - - - Any protein complex that is part of the plasma membrane. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. - biological_process - GO:0098801 - regulation of renal system process - - - - - Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. - GOC:dos - - - - - - - - - - - - - - - The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. - biological_process - GO:0098813 - nuclear chromosome segregation - - - - - The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a protein along a microtubule, mediated by motor proteins. - microtubule-based protein transport - biological_process - GO:0098840 - protein transport along microtubule - - - - - The directed movement of a protein along a microtubule, mediated by motor proteins. - PMID:25987607 - - - - - - - - - - - - - - - A cell projection supported by an assembly of actin filaments, and which lacks microtubules. - cellular_component - GO:0098858 - actin-based cell projection - - - - - A cell projection supported by an assembly of actin filaments, and which lacks microtubules. - PMID:15661519 - - - - - - - - - - - - - - - - - - - - - - - - - - The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone. - biological_process - GO:0098867 - intramembranous bone growth - - - - - The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone. - PMID:26399686 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The increase in size or mass of a bone that contributes to the shaping of that bone. - biological_process - GO:0098868 - bone growth - - - - - The increase in size or mass of a bone that contributes to the shaping of that bone. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - The actin cytoskeleton that is part of a postsynapse. - cellular_component - GO:0098871 - - postsynaptic actin cytoskeleton - - - - - The actin cytoskeleton that is part of a postsynapse. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis. - biological_process - GO:0098876 - vesicle-mediated transport to the plasma membrane - - - - - The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared. - synapse clearance - synapse disassembly - synapse elimination - synapse removal - biological_process - GO:0098883 - - synapse pruning - - - - - A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared. - GOC:dos - PMID:12062020 - PMID:18083105 - PMID:22632716 - PMID:29844190 - - - - - synapse clearance - GOC:aruk - GOC:bc - PMID:22632716 - - - - - synapse disassembly - PMID:12062020 - - - - - - synapse elimination - GOC:aruk - GOC:bc - PMID:18083105 - PMID:29844190 - - - - - synapse removal - GOC:aruk - GOC:bc - PMID:22632716 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. - biological_process - GO:0098900 - The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term. - regulation of action potential - - - - - Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. - GOC:dos - GOC:dph - GOC:go_curators - GOC:tb - ISBN:978-0-07-139011-8 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. - biological_process - GO:0098901 - regulation of cardiac muscle cell action potential - - - - - Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. - GOC:dos - GOC:mtg_cardiac_conduct_nov11 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. - tb - 2011-11-10T08:58:56Z - regulation of AV node cardiac muscle cell action potential - regulation of atrioventricular node cardiac muscle cell action potential - biological_process - GO:0098904 - regulation of AV node cell action potential - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. - tb - 2011-11-10T08:58:56Z - biological_process - GO:0098906 - regulation of Purkinje myocyte action potential - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. - tb - 2011-11-10T08:50:15Z - regulation of SA node cardiac muscle cell action potential - regulation of SAN cardiac muscle cell action potential - regulation of sinoatrial node cardiac muscle cell action potential - regulation of sinus node cardiac muscle cell action potential - biological_process - GO:0098907 - regulation of SA node cell action potential - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. - GOC:BHF - GOC:mtg_cardiac_conduct_nov11 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. - biological_process - generation of action potential - GO:0098908 - regulation of neuronal action potential - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. - GOC:dph - GOC:isa_complete - GOC:tb - - - - - generation of action potential - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Cell-cell signaling from pre to post-synapse, across the synaptic cleft. - biological_process - GO:0098916 - anterograde trans-synaptic signaling - - - - - Cell-cell signaling from pre to post-synapse, across the synaptic cleft. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Cell-cell signaling from post to pre-synapse, across the synaptic cleft. - biological_process - GO:0098917 - retrograde trans-synaptic signaling - - - - - Cell-cell signaling from post to pre-synapse, across the synaptic cleft. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand. - biological_process - GO:0098920 - - retrograde trans-synaptic signaling by lipid - - - - - Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Signal transduction in which the initial step occurs in a postsynapse. - postsynaptic signaling pathway - biological_process - GO:0098926 - - postsynaptic signal transduction - - - - - Signal transduction in which the initial step occurs in a postsynapse. - GOC:dos - - - - - postsynaptic signaling pathway - - - - - - - - - - - - - - - - - - - - - - - - - - - Signal transduction in which the initial step occurs in a presynapse. - presynaptic signaling pathway - biological_process - GO:0098928 - - presynaptic signal transduction - - - - - Signal transduction in which the initial step occurs in a presynapse. - GOC:dos - - - - - presynaptic signaling pathway - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton. - biological_process - GO:0098974 - - postsynaptic actin cytoskeleton organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma. - cellular_component - GO:0098975 - postsynapse of neuromuscular junction - - - - - The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma. - GOC:dos - Wikipedia:Neuromuscular_junction&oldid=723623502 - - - - - - - - - - - - - - - - - - - - - - - - - - A synapse that uses acetylcholine as a neurotransmitter. - cellular_component - GO:0098981 - - cholinergic synapse - - - - - A synapse that uses acetylcholine as a neurotransmitter. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. - cellular_component - GO:0098992 - - neuronal dense core vesicle - - - - - A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. - GOC:dos - ISBN:978-0-07-181001-2 - Wikipedia:Neuropeptide&oldid=713905176 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any vesicle-mediated transport that occurs in a synapse. - biological_process - GO:0099003 - - vesicle-mediated transport in synapse - - - - - Any vesicle-mediated transport that occurs in a synapse. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The lipid bilayer surrounding a neuronal dense core vesicle. - cellular_component - GO:0099012 - - neuronal dense core vesicle membrane - - - - - The lipid bilayer surrounding a neuronal dense core vesicle. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle. - biological_process - GO:0099014 - neuronal dense core vesicle organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of a set of components to form a presynapse. - presynapse biogenesis - presynaptic terminal assembly - biological_process - GO:0099054 - - presynapse assembly - - - - - The aggregation, arrangement and bonding together of a set of components to form a presynapse. - GOC:PARL - GOC:bf - GOC:dos - PMID:24449494 - - - - - presynapse biogenesis - GOC:mah - - - - - presynaptic terminal assembly - PMID:24449494 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of a set of components to form a postsynapse. - postsynapse biogenesis - biological_process - GO:0099068 - postsynapse assembly - - - - - The aggregation, arrangement and bonding together of a set of components to form a postsynapse. - GOC:bf - GOC:dos - GOCL:PARL - - - - - postsynapse biogenesis - GOC:mah - - - - - - - - - A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. - cellular_component - GO:0099080 - supramolecular complex - - - - - A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - A polymeric supramolecular structure. - cellular_component - GO:0099081 - supramolecular polymer - - - - - A polymeric supramolecular structure. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide. - biological_process - GO:0099082 - - retrograde trans-synaptic signaling by neuropeptide - - - - - Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide. - GOC:PARL - GOC:bf - GOC:dos - PMID:19448629 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Modulation of synaptic transmittion by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide. - biological_process - GO:0099083 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission - - - - - Modulation of synaptic transmittion by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide. - GOC:PARL - GOC:bf - GOC:dos - PMID:19448629 - - - - - - - - - - - - - - - - - - - - - - - - - - The movement of a cellular component as a result of microtubule polymerization. - biological_process - GO:0099098 - microtubule polymerization based movement - - - - - The movement of a cellular component as a result of microtubule polymerization. - GOC:cjm - ISBN:0815316194 - - - - - - - - - - - - - - - - - - - - - - - - - - A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. - biological_process - GO:0099111 - microtubule-based transport - - - - - A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. - GOC:cjm - ISBN:0815316194 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The transport of a protein driven by polymerization of a microtubule to which it is attached. - biological_process - GO:0099112 - microtubule polymerization based protein transport - - - - - The transport of a protein driven by polymerization of a microtubule to which it is attached. - GOC:dos - GOC:vw - PMID:11018050 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A microtubule-based process that results in the transport of proteins. - biological_process - GO:0099118 - microtubule-based protein transport - - - - - A microtubule-based process that results in the transport of proteins. - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton. - dos - 2017-06-09T18:34:19Z - biological_process - GO:0099140 - - presynaptic actin cytoskeleton organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - The actin cytoskeleton that is part of a presynapse. - dos - 2017-06-09T18:36:19Z - cellular_component - GO:0099143 - - presynaptic actin cytoskeleton - - - - - The actin cytoskeleton that is part of a presynapse. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - Cell-cell signaling in which the ligand is carried between cells by an exosome. - dos - 2017-07-05T16:40:45Z - exosome mediated - biological_process - GO:0099156 - cell-cell signaling via exosome - - - - - Cell-cell signaling in which the ligand is carried between cells by an exosome. - GOC:dos - PMID:19837038 - - - - - - - - - - - - - - - - - - - - - - - - - - - Transynaptic signaling in which the ligand is carried across the synapse by an exosome. - dos - 2017-07-05T16:49:44Z - exosome mediated transynaptic signalling - trans-synaptic signalling via exosome - biological_process - GO:0099157 - - trans-synaptic signaling via exosome - - - - - Transynaptic signaling in which the ligand is carried across the synapse by an exosome. - GOC:dos - PMID:19837038 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission. - dos - 2017-09-11T17:09:17Z - biological_process - GO:0099170 - - postsynaptic modulation of chemical synaptic transmission - - - - - Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - Any process, acting in the presynapse that results in modulation of chemical synaptic transmission. - dos - 2017-09-11T17:09:31Z - biological_process - GO:0099171 - - presynaptic modulation of chemical synaptic transmission - - - - - Any process, acting in the presynapse that results in modulation of chemical synaptic transmission. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse. - presynapse development - presynapse organisation - biological_process - presynapse morphogenesis - presynapse organization and biogenesis - GO:0099172 - - presynapse organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse. - GOC:dos - - - - - presynapse morphogenesis - GOC:BHF - - - - - presynapse organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse. - postsynapse development - postsynapse organisation - biological_process - postsynapse morphogenesis - postsynapse organization and biogenesis - GO:0099173 - - postsynapse organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse. - GOC:dos - - - - - postsynapse morphogenesis - GOC:BHF - - - - - postsynapse organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the physical form of a presynapse. - regulation of presynapse organisation - regulation of presynapse structure - biological_process - regulation of presynapse organization and biogenesis - GO:0099174 - - regulation of presynapse organization - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the physical form of a presynapse. - GOC:ai - GOC:dph - GOC:tb - - - - - regulation of presynapse organisation - GOC:mah - - - - - regulation of presynapse organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the physical form of a postsynapse. - regulation of postsynapse organisation - regulation of postsynapse structure - biological_process - regulation of postsynapse organization and biogenesis - GO:0099175 - - regulation of postsynapse organization - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the physical form of a postsynapse. - GOC:ai - GOC:dph - GOC:tb - - - - - regulation of postsynapse organisation - GOC:mah - - - - - regulation of postsynapse organization and biogenesis - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of trans-synaptic signaling. - biological_process - GO:0099177 - regulation of trans-synaptic signaling - - - - - Any process that modulates the frequency, rate or extent of trans-synaptic signaling. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton. - dos - 2017-12-20T15:05:34Z - biological_process - GO:0099187 - presynaptic cytoskeleton organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton. - dos - 2017-12-20T15:06:57Z - biological_process - GO:0099188 - - postsynaptic cytoskeleton organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. - biological_process - GO:0099500 - vesicle fusion to plasma membrane - - - - - Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. - GOC:aruk - GOC:bc - ISBN:0071120009 - PMID:18618940 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The lipid bilayer surrounding an exocytic vesicle. - secretory vesicle membrane - cellular_component - GO:0099501 - exocytic vesicle membrane - - - - - The lipid bilayer surrounding an exocytic vesicle. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. - cellular_component - GO:0099503 - - secretory vesicle - - - - - A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. - GO:0043205 - cellular_component - fibril - GO:0099512 - supramolecular fiber - - - - - A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits. - cellular_component - GO:0099513 - polymeric cytoskeletal fiber - - - - - A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - The transport of organelles or other particles from one location in the cell to another along actin filaments. - tb - 2009-05-27T10:56:08Z - biological_process - GO:0099515 - actin filament-based transport - - - - - The transport of organelles or other particles from one location in the cell to another along actin filaments. - GOC:dos - GOC:dph - GOC:mah - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. - cytoskeletal fiber-based vesicle localization - vesicle cytoskeletal transport - biological_process - GO:0099518 - vesicle cytoskeletal trafficking - - - - - The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. - GOC:ecd - GOC:rl - - - - - cytoskeletal fiber-based vesicle localization - GOC:rl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. - biological_process - GO:0099531 - - - presynaptic process involved in chemical synaptic transmission - - - - - The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Cell-cell signaling to, from or within a synapse. - biological_process - GO:0099536 - - - synaptic signaling - - - - - Cell-cell signaling to, from or within a synapse. - GOC:dos - - - - - - - - - Cell-cell signaling in either direction across the synaptic cleft. - biological_process - GO:0099537 - - trans-synaptic signaling - - - - - Cell-cell signaling in either direction across the synaptic cleft. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - Cell-cell signaling to or from a synapse, mediated by a peptide. - biological_process - GO:0099538 - - synaptic signaling via neuropeptide - - - - - Cell-cell signaling to or from a synapse, mediated by a peptide. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft. - biological_process - GO:0099540 - - trans-synaptic signaling by neuropeptide - - - - - Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid. - biological_process - GO:0099541 - - trans-synaptic signaling by lipid - - - - - Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission. - biological_process - GO:0099546 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - protein catabolic process, modulating synaptic transmission - - - - - Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission. - GOC:dos - PMID:23083742 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates synaptic transmission by regulating translation occurring at the synapse. - biological_process - GO:0099547 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - regulation of translation at synapse, modulating synaptic transmission - - - - - Any process that modulates synaptic transmission by regulating translation occurring at the synapse. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse. - biological_process - GO:0099550 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - trans-synaptic signaling, modulating synaptic transmission - - - - - Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse. - biological_process - GO:0099551 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - trans-synaptic signaling by neuropeptide, modulating synaptic transmission - - - - - Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse. - biological_process - GO:0099552 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - trans-synaptic signaling by lipid, modulating synaptic transmission - - - - - Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse. - GOC:dos - PMID:21531987 - - - - - - - - - - - - - - - - - - - - - - - - - - Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. - cellular_component - GO:0099568 - - cytoplasmic region - - - - - Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - The portion of the cytoskeleton contained within the presynapse. - cellular_component - GO:0099569 - - presynaptic cytoskeleton - - - - - The portion of the cytoskeleton contained within the presynapse. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - The portion of the cytoskeleton contained within the postsynapse. - cellular_component - GO:0099571 - - postsynaptic cytoskeleton - - - - - The portion of the cytoskeleton contained within the postsynapse. - GOC:dos - PMID:19889835 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates synaptic transmission by regulating protein degradation at the synapse. - biological_process - GO:0099574 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - regulation of protein catabolic process at synapse, modulating synaptic transmission - - - - - Any process that modulates synaptic transmission by regulating protein degradation at the synapse. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse. - biological_process - GO:0099575 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - regulation of protein catabolic process at presynapse, modulating synaptic transmission - - - - - Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse. - biological_process - GO:0099576 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - regulation of protein catabolic process at postsynapse, modulating synaptic transmission - - - - - Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates synaptic transmission by regulating translation occurring at the presynapse. - biological_process - GO:0099577 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - regulation of translation at presynapse, modulating synaptic transmission - - - - - Any process that modulates synaptic transmission by regulating translation occurring at the presynapse. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse. - biological_process - GO:0099578 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - regulation of translation at postsynapse, modulating synaptic transmission - - - - - Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which protein is transported from one region of the plasma membrane to another. - biological_process - GO:0099632 - protein transport within plasma membrane - - - - - A process in which protein is transported from one region of the plasma membrane to another. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of proteins along microtubules in neuron projections. - axonal protein transport - biological_process - GO:0099640 - - axo-dendritic protein transport - - - - - The directed movement of proteins along microtubules in neuron projections. - ISBN:0815316194 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any signal release from a synapse. - biological_process - GO:0099643 - - signal release from synapse - - - - - Any signal release from a synapse. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - The complete extent of cell cortex that underlies some some region of the plasma membrane. - perimembrane region - cellular_component - GO:0099738 - - cell cortex region - - - - - The complete extent of cell cortex that underlies some some region of the plasma membrane. - GOC:dos - - - - - - - - - - - - - - - - - - - - - - - - - - - Any action potential process that regulates skeletal muscle contraction. - cjm - 2015-04-02T04:13:19Z - biological_process - GO:0100001 - regulation of skeletal muscle contraction by action potential - - - - - Any action potential process that regulates skeletal muscle contraction. - GOC:cjm - GOC:obol - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population. - biological_process - GO:0101023 - vascular endothelial cell proliferation - - - - - The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population. - GOC:BHF - GOC:BHF_telomere - GOC:nc - PMID:23201774 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis. - https://github.com/geneontology/go-ontology/issues/19949 - nuclear membrane organization involved in mitotic nuclear division - biological_process - GO:0101024 - This process only occurs in organisms which undergo 'closed mitosis' without nuclear breakdown. - mitotic nuclear membrane organization - - - - - A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis. - GOC:vw - PMID:15147872 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a nuclear membrane is synthesized, aggregates, and bonds together. - biological_process - GO:0101025 - nuclear membrane biogenesis - - - - - The process in which a nuclear membrane is synthesized, aggregates, and bonds together. - GOC:vw - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite. - hjd - 2017-06-23T18:30:18Z - biological_process - GO:0106027 - neuron projection organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite. - GOC:aruk - GOC:bc - PMID:11585923 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus. - hjd - 2019-06-27T15:12:22Z - biological_process - GO:0106214 - regulation of vesicle fusion with Golgi apparatus - - - - - Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus. - GOC:se - PMID:26195667 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus. - hjd - 2019-06-27T15:17:17Z - biological_process - GO:0106215 - negative regulation of vesicle fusion with Golgi apparatus - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus. - GOC:se - PMID:26195667 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus. - hjd - 2019-06-27T15:20:59Z - biological_process - GO:0106216 - positive regulation of vesicle fusion with Golgi apparatus - - - - - Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus. - GOC:se - PMID:26195667 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane. - kmv - biological_process - GO:0110011 - regulation of basement membrane organization - - - - - Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane. - GOC:ha - PMID:27404358 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. - kmv - 2017-06-20T19:28:58Z - biological_process - GO:0110020 - regulation of actomyosin structure organization - - - - - Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. - GOC:lf - PMID:22790195 - - - - - - - - - - - - - - - - - - - - - - - - - - The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. - kmv - 2017-06-29T14:35:24Z - biological_process - GO:0110021 - cardiac muscle myoblast proliferation - - - - - The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. - GOC:BHF - GOC:BHF_miRNA - GOC:rph - PMID:26512644 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation. - kmv - 2017-06-29T15:11:47Z - biological_process - GO:0110022 - regulation of cardiac muscle myoblast proliferation - - - - - Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation. - GOC:BHF - GOC:BHF_miRNA - GOC:rph - PMID:26512644 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation. - kmv - 2017-06-29T15:18:30Z - biological_process - GO:0110023 - negative regulation of cardiac muscle myoblast proliferation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation. - GOC:BHF - GOC:BHF_miRNA - GOC:rph - PMID:26512644 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation. - kmv - 2017-06-29T15:24:16Z - biological_process - GO:0110024 - positive regulation of cardiac muscle myoblast proliferation - - - - - Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation. - GOC:BHF - GOC:BHF_miRNA - GOC:rph - PMID:26512644 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of actin filament organization. - kmv - 2017-09-20T19:52:57Z - biological_process - GO:0110053 - regulation of actin filament organization - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of actin filament organization. - GOC:kmv - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation. - kmv - 2017-10-23T14:32:09Z - biological_process - GO:0110057 - regulation of blood vessel endothelial cell differentiation - - - - - Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation. - GOC:BHF - GOC:BHF_miRNA - GOC:rph - PMID:23072816 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation. - kmv - 2017-10-23T14:38:19Z - biological_process - GO:0110058 - positive regulation of blood vessel endothelial cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation. - GOC:BHF - GOC:BHF_miRNA - GOC:rph - PMID:23072816 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation. - kmv - 2017-10-23T14:47:29Z - biological_process - GO:0110059 - negative regulation of blood vessel endothelial cell differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation. - GOC:BHF - GOC:BHF_miRNA - GOC:rph - PMID:23072816 - - - - - - - - - - - - - - - - - - - - - - - - - - - A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane. - kmv - 2018-01-29T14:46:52Z - biological_process - GO:0110077 - vesicle-mediated intercellular transport - - - - - A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane. - GOC:sp - PMID:29328915 - PMID:29328916 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis. - kmv - 2018-07-05T14:10:14Z - biological_process - GO:0110110 - positive regulation of animal organ morphogenesis - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis. - GOC:kmv - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis. - kmv - 2018-07-05T14:25:21Z - biological_process - GO:0110111 - negative regulation of animal organ morphogenesis - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis. - GOC:kmv - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate, or extent of lipid transporter activity. - kmv - 2018-07-06T18:53:55Z - biological_process - GO:0110112 - - regulation of lipid transporter activity - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate, or extent of lipid transporter activity. - GOC:BHF - GOC:BHF_miRNA - GOC:rph - PMID:27365390 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that increases the frequency, rate, or extent of lipid transporter activity. - kmv - 2018-07-06T19:14:13Z - biological_process - GO:0110113 - - positive regulation of lipid transporter activity - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that increases the frequency, rate, or extent of lipid transporter activity. - GOC:BHF - GOC:BHF_miRNA - GOC:rph - PMID:27365390 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that decreases the frequency, rate, or extent of lipid transporter activity. - kmv - 2018-07-06T19:21:44Z - biological_process - GO:0110114 - - negative regulation of lipid transporter activity - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that decreases the frequency, rate, or extent of lipid transporter activity. - GOC:BHF - GOC:BHF_miRNA - GOC:rph - PMID:27365390 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation. - kmv - 2018-07-16T18:08:49Z - biological_process - GO:0110116 - regulation of compound eye photoreceptor cell differentiation - - - - - Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation. - GOC:ha - PMID:16377567 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation. - kmv - 2018-07-16T18:13:28Z - biological_process - GO:0110117 - positive regulation of compound eye photoreceptor cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation. - GOC:ha - PMID:16377567 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation. - kmv - 2018-07-16T18:15:52Z - biological_process - GO:0110118 - negative regulation of compound eye photoreceptor cell differentiation - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation. - GOC:ha - PMID:16377567 - - - - - - - - - - - A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. - https://github.com/geneontology/go-ontology/issues/24200 - kmv - 2019-08-12T18:01:37Z - cellular_component - GO:0110165 - - - cellular anatomical entity - - - - - A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. - GOC:kmv - - - - - - - - - - - - - - - - - - - - - - - - - - A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. - https://github.com/geneontology/go-ontology/issues/13193 - krc - 2017-03-21T17:26:07Z - cellular_component - GO:0120025 - plasma membrane bounded cell projection - - - - - A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - - Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. - https://github.com/geneontology/go-ontology/issues/13298 - krc - 2017-04-24T23:56:08Z - eupodium - biological_process - GO:0120031 - plasma membrane bounded cell projection assembly - - - - - Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. - GOC:krc - - - - - eupodium - GOC:krc - GOC:rjd - PMID:10328951 - PMID:9096956 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly. - https://github.com/geneontology/go-ontology/issues/13298 - krc - 2017-04-26T04:27:04Z - biological_process - GO:0120032 - regulation of plasma membrane bounded cell projection assembly - - - - - Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly. - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly. - https://github.com/geneontology/go-ontology/issues/13298 - krc - 2017-04-26T04:34:31Z - biological_process - GO:0120033 - negative regulation of plasma membrane bounded cell projection assembly - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly. - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly. - https://github.com/geneontology/go-ontology/issues/13298 - krc - 2017-04-26T04:34:45Z - biological_process - GO:0120034 - positive regulation of plasma membrane bounded cell projection assembly - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly. - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections. - https://github.com/geneontology/go-ontology/issues/13298 - krc - 2017-04-26T16:02:06Z - biological_process - GO:0120035 - regulation of plasma membrane bounded cell projection organization - - - - - Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections. - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon. - https://github.com/geneontology/go-ontology/issues/13298 - krc - 2017-04-26T16:07:02Z - biological_process - GO:0120036 - plasma membrane bounded cell projection organization - - - - - A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon. - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized. - https://github.com/geneontology/go-ontology/issues/13298 - krc - 2017-04-28T23:39:37Z - biological_process - GO:0120039 - plasma membrane bounded cell projection morphogenesis - - - - - The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized. - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection. - https://github.com/geneontology/go-ontology/issues/14472 - krc - 2017-11-01T18:58:12Z - cellular_component - GO:0120111 - neuron projection cytoplasm - - - - - All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection. - GOC:ha - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. - https://github.com/geneontology/go-ontology/issues/15720 - krc - 2018-05-11T16:31:42Z - positive regulation of collagen breakdown - positive regulation of collagen catabolism - positive regulation of collagen degradation - up regulation of collagen catabolic process - up-regulation of collagen catabolic process - upregulation of collagen catabolic process - activation of collagen catabolic process - biological_process - GO:0120158 - positive regulation of collagen catabolic process - - - - - Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. - GOC:dph - GOC:tb - - - - - positive regulation of collagen breakdown - GOC:dph - GOC:tb - - - - - positive regulation of collagen catabolism - GOC:dph - GOC:tb - - - - - positive regulation of collagen degradation - GOC:dph - GOC:tb - - - - - up regulation of collagen catabolic process - GOC:dph - GOC:tb - - - - - up-regulation of collagen catabolic process - GOC:dph - GOC:tb - - - - - upregulation of collagen catabolic process - GOC:dph - GOC:tb - - - - - activation of collagen catabolic process - GOC:dph - GOC:tb - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. - https://github.com/geneontology/go-ontology/issues/16000 - krc - 2019-05-20T22:34:00Z - biological_process - GO:0120178 - steroid hormone biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. - GOC:krc - GOC:nln - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin. - https://github.com/geneontology/go-ontology/issues/16012 - krc - 2018-07-14T00:19:32Z - negative regulation of protein localisation to chromatin - biological_process - GO:0120186 - negative regulation of protein localization to chromatin - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin. - PMID:20889714 - PMID:29899453 - - - - - negative regulation of protein localisation to chromatin - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to chromatin. - https://github.com/geneontology/go-ontology/issues/16012 - krc - 2018-07-14T00:21:28Z - positive regulation of protein localisation to chromatin - biological_process - GO:0120187 - positive regulation of protein localization to chromatin - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to chromatin. - PMID:20889714 - PMID:29899453 - - - - - positive regulation of protein localisation to chromatin - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. - https://github.com/geneontology/go-ontology/issues/16040 - krc - 2018-07-16T22:28:58Z - biological_process - GO:0120188 - regulation of bile acid secretion - - - - - Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. - GOC:BHF - GOC:BHF_miRNA - GOC:rph - PMID:22767443 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. - https://github.com/geneontology/go-ontology/issues/16040 - krc - 2018-07-16T22:36:17Z - biological_process - GO:0120189 - positive regulation of bile acid secretion - - - - - Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. - GOC:BHF - GOC:BHF_miRNA - GOC:rph - PMID:22767443 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. - https://github.com/geneontology/go-ontology/issues/16040 - krc - 2018-07-16T22:38:34Z - biological_process - GO:0120190 - negative regulation of bile acid secretion - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. - GOC:BHF - GOC:BHF_miRNA - GOC:rph - PMID:22767443 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of blastocyst development. - https://github.com/geneontology/go-ontology/issues/18871 - krc - 2020-02-17T19:59:20Z - biological_process - GO:0120222 - regulation of blastocyst development - - - - - Any process that modulates the frequency, rate or extent of blastocyst development. - GOC:krc - PMID:29593216 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism. - https://github.com/geneontology/go-ontology/issues/20524 - krc - 2021-02-09T19:37:35Z - biological_process - GO:0120305 - regulation of pigmentation - - - - - Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism. - GOC:krc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process pertaining to the initial formation of an endothelial tube. - https://github.com/geneontology/go-ontology/issues/22302 - krc - 2022-05-25T16:17:59Z - biological_process - GO:0120331 - endothelial tube formation - - - - - The developmental process pertaining to the initial formation of an endothelial tube. - GOC:sl - PMID:23239824 - - - - - - - - - - - - - - - - - - - - - - - - - - - One of the two nuclear divisions that occur as part of the meiotic cell cycle. - https://github.com/geneontology/go-ontology/issues/19910 - pg - 2017-03-23T09:40:00Z - meiosis - biological_process - GO:0140013 - - meiotic nuclear division - - - - - One of the two nuclear divisions that occur as part of the meiotic cell cycle. - PMID:9334324 - - - - - - - - - - - - - - - - - - - - - - - - - - - A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. - https://github.com/geneontology/go-ontology/issues/19910 - pg - 2017-03-23T14:44:23Z - mitosis - biological_process - GO:0140014 - - - mitotic nuclear division - - - - - A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. - ISBN:0198547684 - - - - - - - - - - - - - - - - - - - - - - - - - - The cellular processes that contribute to exocytosis. - pg - 2017-05-15T13:20:45Z - biological_process - GO:0140029 - - exocytic process - - - - - The cellular processes that contribute to exocytosis. - Wikipedia:Exocytosis - - - - - - - - - - The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other. - pg - 2017-06-27T09:58:51Z - biological_process - GO:0140056 - - organelle localization by membrane tethering - - - - - The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other. - PMID:27875684 - - - - - - - - - - - - - - - - - - - - - - - - - - Catalytic activity that acts to modify a protein. - https://github.com/geneontology/go-ontology/issues/14225 - pg - 2017-09-14T10:32:59Z - molecular_function - GO:0140096 - - - catalytic activity, acting on a protein - - - - - Catalytic activity that acts to modify a protein. - GOC:molecular_function_refactoring - GOC:pdt - - - - - - - - - - - - - - - - - - - - - - - - - - Catalytic activity that acts to modify DNA. - https://github.com/geneontology/go-ontology/issues/14225 - pg - 2017-09-14T12:03:51Z - molecular_function - GO:0140097 - - - catalytic activity, acting on DNA - - - - - Catalytic activity that acts to modify DNA. - GOC:molecular_function_refactoring - GOC:pdt - - - - - - - - - - - - - - - - - - - - - - - - - - Catalytic activity that acts to modify RNA, driven by ATP hydrolysis. - https://github.com/geneontology/go-ontology/issues/14225 - https://github.com/geneontology/go-ontology/issues/21612 - pg - 2017-09-14T12:05:21Z - molecular_function - GO:0140098 - - - catalytic activity, acting on RNA - - - - - Catalytic activity that acts to modify RNA, driven by ATP hydrolysis. - GOC:molecular_function_refactoring - GOC:pdt - - - - - - - - - - - - - - - - - - - - - - - - - - Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein. - https://github.com/geneontology/go-ontology/issues/14225 - pg - 2017-09-15T19:27:54Z - molecular_function - GO:0140103 - catalytic activity, acting on a glycoprotein - - - - - Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein. - GOC:molecular_function_refactoring - GOC:pdt - - - - - - - - - The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content. - https://github.com/geneontology/go-ontology/issues/14256 - pg - 2017-10-23T11:53:42Z - extracellular vesicle assembly - biological_process - GO:0140112 - extracellular vesicle biogenesis - - - - - The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content. - PMID:28736435 - - - - - - - - - - - - - - - - - - - - - - - - - - Translation that occurs at the presynapse. - https://github.com/geneontology/synapse/issues/216 - pg - 2018-07-13T13:00:33Z - biological_process - GO:0140236 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - translation at presynapse - - - - - Translation that occurs at the presynapse. - PMID:27321671 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Translation that occurs at the presynapse, and that modulates chemical synaptic transmission. - https://github.com/geneontology/synapse/issues/216 - pg - 2018-07-13T13:07:23Z - biological_process - GO:0140237 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - translation at presynapse, modulating chemical synaptic transmission - - - - - Translation that occurs at the presynapse, and that modulates chemical synaptic transmission. - PMID:27321671 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Translation that occurs at the synapse. - https://github.com/geneontology/synapse/issues/210 - pg - 2018-07-15T09:23:12Z - biological_process - GO:0140241 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - translation at synapse - - - - - Translation that occurs at the synapse. - PMID:23083742 - - - - - - - - - - - - - - - - - - - - - - - - - - Translation that occurs at the postsynapse. - https://github.com/geneontology/synapse/issues/210 - pg - 2018-07-15T09:26:27Z - biological_process - GO:0140242 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - translation at postsynapse - - - - - Translation that occurs at the postsynapse. - PMID:20427644 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that regulates translation occurring at the synapse. - https://github.com/geneontology/synapse/issues/210 - pg - 2018-07-15T09:38:26Z - biological_process - GO:0140243 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - regulation of translation at synapse - - - - - Any process that regulates translation occurring at the synapse. - PMID:20427644 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that regulates translation occurring at the presynapse. - https://github.com/geneontology/synapse/issues/210 - pg - 2018-07-15T09:38:33Z - biological_process - GO:0140244 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - regulation of translation at presynapse - - - - - Any process that regulates translation occurring at the presynapse. - PMID:20427644 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that regulates translation occurring at the postsynapse. - https://github.com/geneontology/synapse/issues/210 - pg - 2018-07-15T09:38:54Z - biological_process - GO:0140245 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - regulation of translation at postsynapse - - - - - Any process that regulates translation occurring at the postsynapse. - PMID:20427644 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of a protein at a synapse. - https://github.com/geneontology/synapse/issues/210 - pg - 2018-07-15T10:12:51Z - biological_process - GO:0140246 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - protein catabolic process at synapse - - - - - The chemical reactions and pathways resulting in the breakdown of a protein at a synapse. - PMID:17062563 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse. - https://github.com/geneontology/synapse/issues/204 - pg - 2018-07-15T10:23:49Z - biological_process - GO:0140247 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - protein catabolic process at presynapse - - - - - The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse. - PMID:27764673 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse. - https://github.com/geneontology/synapse/issues/204 - pg - 2018-07-15T10:25:04Z - biological_process - GO:0140249 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - protein catabolic process at postsynapse - - - - - The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse. - PMID:17062563 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse. - https://github.com/geneontology/synapse/issues/204 - pg - 2018-07-15T10:34:56Z - biological_process - GO:0140250 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - regulation protein catabolic process at synapse - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse. - PMID:23083742 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse. - https://github.com/geneontology/synapse/issues/204 - pg - 2018-07-15T10:35:39Z - biological_process - GO:0140251 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - regulation protein catabolic process at presynapse - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse. - PMID:27764673 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse. - https://github.com/geneontology/synapse/issues/204 - pg - 2018-07-15T10:35:56Z - biological_process - GO:0140252 - - Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. - regulation protein catabolic process at postsynapse - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse. - PMID:17062563 - - - - - - - - - - - - - - - A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium. - https://github.com/geneontology/go-ontology/issues/15939 - pg - 2018-08-13T18:38:18Z - cell fusion - cell cell fusion - biological_process - GO:0140253 - cell-cell fusion - - - - - A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium. - Wikipedia:Cell_fusion - - - - - - - - - - - - - - - - - - - - - - - - - - Directly binding to a specific protein and delivering it to a specific cellular location. - https://github.com/geneontology/go-ontology/issues/17073 - pg - 2019-04-01T10:41:38Z - Reactome:R-HSA-2248891 - Reactome:R-HSA-9662747 - Reactome:R-HSA-9662818 - molecular_function - protein carrier activity - protein transport chaperone - GO:0140318 - Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation. - protein transporter activity - - - - - Directly binding to a specific protein and delivering it to a specific cellular location. - PMID:18706423 - - - - - Reactome:R-HSA-2248891 - M6PR transports activated ARSA to the lysosome - - - - - Reactome:R-HSA-9662747 - iRHOM2 transports ADAM17 from ER to the Golgi-network - - - - - Reactome:R-HSA-9662818 - iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis. - pg - 2019-05-22T11:20:45Z - efflux - biological_process - GO:0140352 - export from cell - - - - - The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis. - GOC:pg - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a lipid from a cell, into the extracellular region. - pg - 2019-05-22T11:33:07Z - lipid efflux - biological_process - GO:0140353 - lipid export from cell - - - - - The directed movement of a lipid from a cell, into the extracellular region. - GOC:pg - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. - pg - 2019-05-22T11:38:15Z - lipid uptake - biological_process - GO:0140354 - lipid import into cell - - - - - The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. - GOC:pg - - - - - - - - - - - - - - - - - - - - - - - - - - A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. - pg - 2020-09-09T05:12:38Z - nuclear complex - cellular_component - GO:0140513 - - nuclear protein-containing complex - - - - - A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. - GOC:pg - - - - - - - - - - - - - - - - - - - - - - - - - - The division of a vacuole within a cell to form two or more separate vacuoles. - https://github.com/geneontology/go-ontology/issues/20639 - pg - 2021-01-04T10:17:58Z - biological_process - GO:0140572 - vacuole fission - - - - - The division of a vacuole within a cell to form two or more separate vacuoles. - PMID:19643199 - - - - - - - - - - - - - - - - - - - - - - - - - - Catalytic activity that acts to modify a nucleic acid. - https://github.com/geneontology/go-ontology/issues/21402 - pg - 2021-05-11T06:31:07Z - molecular_function - GO:0140640 - catalytic activity, acting on a nucleic acid - - - - - Catalytic activity that acts to modify a nucleic acid. - GOC:pg - - - - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle. - https://github.com/geneontology/go-ontology/issues/21939 - pg - 2021-08-09T15:30:06Z - non-membrane-bounded organelle formation - non-membrane-enclosed organelle assembly - non-membrane-enclosed organelle formation - biological_process - GO:0140694 - non-membrane-bounded organelle assembly - - - - - The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle. - PMID:28225081 - - - - - - - - - - - - - - - - - - - - - - - - - - The elimination of ammonium ions from an excretory cell. - https://github.com/geneontology/go-ontology/issues/22368 - pg - 2021-11-24T17:55:51Z - biological_process - ammonia excretion - GO:0140734 - ammonium excretion - - - - - The elimination of ammonium ions from an excretory cell. - PMID:25740900 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process carried out at the cellular level that reduces or removes the toxicity of a metal ion. - pg - 2022-12-07T15:35:18Z - cellular detoxification of metal cation - biological_process - GO:0140961 - cellular detoxification of metal ion - - - - - Any process carried out at the cellular level that reduces or removes the toxicity of a metal ion. - PMID:26729300 - PMID:33046888 - PMID:34442707 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse. - bc - 2018-05-08T16:38:55Z - biological_process - GO:0150052 - - regulation of postsynapse assembly - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse. - GOC:aruk - GOC:bc - PMID:16394100 - PMID:16672654 - PMID:28185854 - - - - - - - - - The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways. - bc - 2018-07-23T10:31:58Z - biological_process - optic pathway development - visual pathway development - GO:0150063 - visual system development - - - - - The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways. - GOC:aruk - GOC:bc - GOC:krc - PMID:15004427 - PMID:20647017 - PMID:22632727 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum. - bc - 2018-12-17T12:28:09Z - glia-neuron signaling - glia-neuron signalling - glia-neurone signaling - glia-neurone signalling - glial cell- neuron signalling - glial cell-neurone signalling - glial cell-neurone singaling - biological_process - GO:0150098 - glial cell-neuron signaling - - - - - Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum. - GOC:aruk - GOC:bc - PMID:14980203 - PMID:16144764 - PMID:16547515 - PMID:18685038 - PMID:27788368 - PMID:9459440 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine. - bc - 2018-12-17T12:30:12Z - neuron-glia signaling - neuron-glia signalling - neuron-glial cell signalling - neurone-glia signaling - neurone-glia signalling - neurone-glial cell signaling - neurone-glial cell signalling - biological_process - GO:0150099 - neuron-glial cell signaling - - - - - Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine. - GOC:aruk - GOC:bc - PMID:10195197 - PMID:10196584 - PMID:10377338 - PMID:10493741 - PMID:11356870 - PMID:11399439 - PMID:15252819 - PMID:27788368 - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained, in a location within a cell-cell junction. - bc - 2019-06-11T11:00:18Z - biological_process - GO:0150105 - protein localization to cell-cell junction - - - - - A process in which a protein is transported to, or maintained, in a location within a cell-cell junction. - GOC:aruk - GOC:bc - PMID:26706435 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction. - bc - 2019-06-11T11:17:15Z - biological_process - GO:0150106 - regulation of protein localization to cell-cell junction - - - - - Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction. - GOC:aruk - GOC:bc - PMID:26706435 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction. - bc - 2019-06-11T11:23:58Z - biological_process - GO:0150107 - positive regulation of protein localization to cell-cell junction - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction. - GOC:aruk - GOC:bc - PMID:26706435 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of transepithelial transport. - bc - 2019-09-15T07:16:49Z - biological_process - GO:0150111 - regulation of transepithelial transport - - - - - Any process that modulates the frequency, rate or extent of transepithelial transport. - GOC:aruk - PMID:27593915 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction. - bc - 2019-11-21T13:53:34Z - negative regulation of protein localisation to cell-cell junction - biological_process - GO:0150119 - negative regulation of protein localization to cell-cell junction - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction. - GOC:aruk - GOC:bc - - - - - - - - - - - - - - - - - - - - - - - - - - - The disaggregation of a cell junction into its constituent components. - bc - 2019-12-08T11:12:13Z - biological_process - GO:0150146 - cell junction disassembly - - - - - The disaggregation of a cell junction into its constituent components. - GOC:aruk - PMID:25490267 - - - - - - - - - - - - - - - - - - - - - - - - - - - The disaggregation of a cell-cell junction into its constituent components. - bc - 2019-12-08T11:16:14Z - biological_process - GO:0150147 - cell-cell junction disassembly - - - - - The disaggregation of a cell-cell junction into its constituent components. - GOC:aruk - PMID:25490267 - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain. - rynl - 2022-07-07T16:49:26Z - somatosensory system development - biological_process - GO:0160038 - somatic sensory system development - - - - - The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain. - PMID:25832476 - PMID:31399790 - - - - - - - - - - - - - - - - - - - - - - - - - - - The regulated release of catecholamine by a cell in which the catecholamine acts as a neurotransmitter. - https://github.com/geneontology/go-ontology/issues/23804 - rynl - 2022-08-17T00:36:44Z - biological_process - GO:0160043 - catecholamine secretion, neurotransmission - - - - - The regulated release of catecholamine by a cell in which the catecholamine acts as a neurotransmitter. - PMID:10191060 - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure. - https://github.com/geneontology/go-ontology/issues/18285 - rynl - 2023-08-29T21:05:28Z - biological_process - GO:0160093 - chordate pharynx development - - - - - The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure. - PMID:23020903 - - - - - - - - - - - - - - - - - - - - - - - - - - Any regulation of signal transduction that takes place in the extracellular region. - bf - 2012-02-22T10:21:48Z - regulation of signaling pathway in extracellular region - regulation of signalling pathway in extracellular region - biological_process - GO:1900115 - extracellular regulation of signal transduction - - - - - Any regulation of signal transduction that takes place in the extracellular region. - GOC:TermGenie - GOC:signaling - - - - - regulation of signaling pathway in extracellular region - GOC:TermGenie - - - - - regulation of signalling pathway in extracellular region - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any negative regulation of signal transduction that takes place in extracellular region. - bf - 2012-02-22T10:27:56Z - down regulation of signal transduction in extracellular region - down-regulation of signal transduction in extracellular region - downregulation of signal transduction in extracellular region - negative regulation of signaling pathway in extracellular region - negative regulation of signalling pathway in extracellular region - extracellular inhibition of signaling pathway - inhibition of signal transduction in extracellular region - biological_process - GO:1900116 - extracellular negative regulation of signal transduction - - - - - Any negative regulation of signal transduction that takes place in extracellular region. - GOC:TermGenie - GOC:signaling - - - - - down regulation of signal transduction in extracellular region - GOC:TermGenie - - - - - down-regulation of signal transduction in extracellular region - GOC:TermGenie - - - - - downregulation of signal transduction in extracellular region - GOC:TermGenie - - - - - negative regulation of signaling pathway in extracellular region - GOC:TermGenie - - - - - negative regulation of signalling pathway in extracellular region - GOC:TermGenie - - - - - extracellular inhibition of signaling pathway - GOC:bf - - - - - inhibition of signal transduction in extracellular region - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of execution phase of apoptosis. - pr - 2012-02-22T11:26:20Z - biological_process - GO:1900117 - regulation of execution phase of apoptosis - - - - - Any process that modulates the frequency, rate or extent of execution phase of apoptosis. - GOC:TermGenie - GOC:mtg_apoptosis - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis. - pr - 2012-02-22T11:26:24Z - down regulation of execution phase of apoptosis - down-regulation of execution phase of apoptosis - downregulation of execution phase of apoptosis - inhibition of execution phase of apoptosis - biological_process - GO:1900118 - negative regulation of execution phase of apoptosis - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis. - GOC:TermGenie - GOC:mtg_apoptosis - - - - - down regulation of execution phase of apoptosis - GOC:TermGenie - - - - - down-regulation of execution phase of apoptosis - GOC:TermGenie - - - - - downregulation of execution phase of apoptosis - GOC:TermGenie - - - - - inhibition of execution phase of apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. - pr - 2012-02-22T11:26:27Z - up regulation of execution phase of apoptosis - up-regulation of execution phase of apoptosis - upregulation of execution phase of apoptosis - activation of execution phase of apoptosis - biological_process - GO:1900119 - positive regulation of execution phase of apoptosis - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. - GOC:TermGenie - GOC:mtg_apoptosis - - - - - up regulation of execution phase of apoptosis - GOC:TermGenie - - - - - up-regulation of execution phase of apoptosis - GOC:TermGenie - - - - - upregulation of execution phase of apoptosis - GOC:TermGenie - - - - - activation of execution phase of apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process. - yaf - 2012-02-23T01:09:21Z - regulation of hyaluronan anabolism - regulation of hyaluronan biosynthesis - regulation of hyaluronan formation - regulation of hyaluronan synthesis - biological_process - GO:1900125 - regulation of hyaluronan biosynthetic process - - - - - Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process. - GOC:TermGenie - GOC:yaf - - - - - regulation of hyaluronan anabolism - GOC:TermGenie - - - - - regulation of hyaluronan biosynthesis - GOC:TermGenie - - - - - regulation of hyaluronan formation - GOC:TermGenie - - - - - regulation of hyaluronan synthesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process. - yaf - 2012-02-23T01:09:29Z - down regulation of hyaluronan anabolism - down regulation of hyaluronan biosynthesis - down regulation of hyaluronan biosynthetic process - down regulation of hyaluronan formation - down regulation of hyaluronan synthesis - down-regulation of hyaluronan anabolism - down-regulation of hyaluronan biosynthesis - down-regulation of hyaluronan biosynthetic process - down-regulation of hyaluronan formation - down-regulation of hyaluronan synthesis - downregulation of hyaluronan anabolism - downregulation of hyaluronan biosynthesis - downregulation of hyaluronan biosynthetic process - downregulation of hyaluronan formation - downregulation of hyaluronan synthesis - inhibition of hyaluronan anabolism - inhibition of hyaluronan biosynthesis - inhibition of hyaluronan formation - inhibition of hyaluronan synthesis - negative regulation of hyaluronan anabolism - negative regulation of hyaluronan biosynthesis - negative regulation of hyaluronan formation - negative regulation of hyaluronan synthesis - inhibition of hyaluronan biosynthetic process - biological_process - GO:1900126 - negative regulation of hyaluronan biosynthetic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process. - GOC:TermGenie - GOC:yaf - - - - - down regulation of hyaluronan anabolism - GOC:TermGenie - - - - - down regulation of hyaluronan biosynthesis - GOC:TermGenie - - - - - down regulation of hyaluronan biosynthetic process - GOC:TermGenie - - - - - down regulation of hyaluronan formation - GOC:TermGenie - - - - - down regulation of hyaluronan synthesis - GOC:TermGenie - - - - - down-regulation of hyaluronan anabolism - GOC:TermGenie - - - - - down-regulation of hyaluronan biosynthesis - GOC:TermGenie - - - - - down-regulation of hyaluronan biosynthetic process - GOC:TermGenie - - - - - down-regulation of hyaluronan formation - GOC:TermGenie - - - - - down-regulation of hyaluronan synthesis - GOC:TermGenie - - - - - downregulation of hyaluronan anabolism - GOC:TermGenie - - - - - downregulation of hyaluronan biosynthesis - GOC:TermGenie - - - - - downregulation of hyaluronan biosynthetic process - GOC:TermGenie - - - - - downregulation of hyaluronan formation - GOC:TermGenie - - - - - downregulation of hyaluronan synthesis - GOC:TermGenie - - - - - inhibition of hyaluronan anabolism - GOC:TermGenie - - - - - inhibition of hyaluronan biosynthesis - GOC:TermGenie - - - - - inhibition of hyaluronan formation - GOC:TermGenie - - - - - inhibition of hyaluronan synthesis - GOC:TermGenie - - - - - negative regulation of hyaluronan anabolism - GOC:TermGenie - - - - - negative regulation of hyaluronan biosynthesis - GOC:TermGenie - - - - - negative regulation of hyaluronan formation - GOC:TermGenie - - - - - negative regulation of hyaluronan synthesis - GOC:TermGenie - - - - - inhibition of hyaluronan biosynthetic process - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process. - yaf - 2012-02-23T01:09:33Z - activation of hyaluronan anabolism - activation of hyaluronan biosynthesis - activation of hyaluronan formation - activation of hyaluronan synthesis - positive regulation of hyaluronan anabolism - positive regulation of hyaluronan biosynthesis - positive regulation of hyaluronan formation - positive regulation of hyaluronan synthesis - up regulation of hyaluronan anabolism - up regulation of hyaluronan biosynthesis - up regulation of hyaluronan biosynthetic process - up regulation of hyaluronan formation - up regulation of hyaluronan synthesis - up-regulation of hyaluronan anabolism - up-regulation of hyaluronan biosynthesis - up-regulation of hyaluronan biosynthetic process - up-regulation of hyaluronan formation - up-regulation of hyaluronan synthesis - upregulation of hyaluronan anabolism - upregulation of hyaluronan biosynthesis - upregulation of hyaluronan biosynthetic process - upregulation of hyaluronan formation - upregulation of hyaluronan synthesis - activation of hyaluronan biosynthetic process - biological_process - GO:1900127 - positive regulation of hyaluronan biosynthetic process - - - - - Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process. - GOC:TermGenie - GOC:yaf - - - - - activation of hyaluronan anabolism - GOC:TermGenie - - - - - activation of hyaluronan biosynthesis - GOC:TermGenie - - - - - activation of hyaluronan formation - GOC:TermGenie - - - - - activation of hyaluronan synthesis - GOC:TermGenie - - - - - positive regulation of hyaluronan anabolism - GOC:TermGenie - - - - - positive regulation of hyaluronan biosynthesis - GOC:TermGenie - - - - - positive regulation of hyaluronan formation - GOC:TermGenie - - - - - positive regulation of hyaluronan synthesis - GOC:TermGenie - - - - - up regulation of hyaluronan anabolism - GOC:TermGenie - - - - - up regulation of hyaluronan biosynthesis - GOC:TermGenie - - - - - up regulation of hyaluronan biosynthetic process - GOC:TermGenie - - - - - up regulation of hyaluronan formation - GOC:TermGenie - - - - - up regulation of hyaluronan synthesis - GOC:TermGenie - - - - - up-regulation of hyaluronan anabolism - GOC:TermGenie - - - - - up-regulation of hyaluronan biosynthesis - GOC:TermGenie - - - - - up-regulation of hyaluronan biosynthetic process - GOC:TermGenie - - - - - up-regulation of hyaluronan formation - GOC:TermGenie - - - - - up-regulation of hyaluronan synthesis - GOC:TermGenie - - - - - upregulation of hyaluronan anabolism - GOC:TermGenie - - - - - upregulation of hyaluronan biosynthesis - GOC:TermGenie - - - - - upregulation of hyaluronan biosynthetic process - GOC:TermGenie - - - - - upregulation of hyaluronan formation - GOC:TermGenie - - - - - upregulation of hyaluronan synthesis - GOC:TermGenie - - - - - activation of hyaluronan biosynthetic process - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of protein localization to nucleus. - bf - 2012-03-12T01:23:44Z - regulation of protein localisation to nucleus - regulation of protein localization in cell nucleus - regulation of protein localization in nucleus - biological_process - GO:1900180 - regulation of protein localization to nucleus - - - - - Any process that modulates the frequency, rate or extent of protein localization to nucleus. - GOC:TermGenie - - - - - regulation of protein localisation to nucleus - GOC:TermGenie - - - - - regulation of protein localization in cell nucleus - GOC:TermGenie - - - - - regulation of protein localization in nucleus - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus. - bf - 2012-03-12T01:23:48Z - down regulation of protein localisation to nucleus - down regulation of protein localization in cell nucleus - down regulation of protein localization in nucleus - down regulation of protein localization to nucleus - down-regulation of protein localisation to nucleus - down-regulation of protein localization in cell nucleus - down-regulation of protein localization in nucleus - down-regulation of protein localization to nucleus - downregulation of protein localisation to nucleus - downregulation of protein localization in cell nucleus - downregulation of protein localization in nucleus - downregulation of protein localization to nucleus - negative regulation of protein localisation to nucleus - negative regulation of protein localization in cell nucleus - negative regulation of protein localization in nucleus - inhibition of protein localisation to nucleus - inhibition of protein localization in cell nucleus - inhibition of protein localization in nucleus - inhibition of protein localization to nucleus - biological_process - GO:1900181 - negative regulation of protein localization to nucleus - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus. - GOC:TermGenie - - - - - down regulation of protein localisation to nucleus - GOC:TermGenie - - - - - down regulation of protein localization in cell nucleus - GOC:TermGenie - - - - - down regulation of protein localization in nucleus - GOC:TermGenie - - - - - down regulation of protein localization to nucleus - GOC:TermGenie - - - - - down-regulation of protein localisation to nucleus - GOC:TermGenie - - - - - down-regulation of protein localization in cell nucleus - GOC:TermGenie - - - - - down-regulation of protein localization in nucleus - GOC:TermGenie - - - - - down-regulation of protein localization to nucleus - GOC:TermGenie - - - - - downregulation of protein localisation to nucleus - GOC:TermGenie - - - - - downregulation of protein localization in cell nucleus - GOC:TermGenie - - - - - downregulation of protein localization in nucleus - GOC:TermGenie - - - - - downregulation of protein localization to nucleus - GOC:TermGenie - - - - - negative regulation of protein localisation to nucleus - GOC:TermGenie - - - - - negative regulation of protein localization in cell nucleus - GOC:TermGenie - - - - - negative regulation of protein localization in nucleus - GOC:TermGenie - - - - - inhibition of protein localisation to nucleus - GOC:TermGenie - - - - - inhibition of protein localization in cell nucleus - GOC:TermGenie - - - - - inhibition of protein localization in nucleus - GOC:TermGenie - - - - - inhibition of protein localization to nucleus - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. - bf - 2012-03-12T01:23:52Z - activation of protein localization in nucleus - positive regulation of protein localisation to nucleus - positive regulation of protein localization in cell nucleus - positive regulation of protein localization in nucleus - up regulation of protein localisation to nucleus - up regulation of protein localization in cell nucleus - up regulation of protein localization in nucleus - up regulation of protein localization to nucleus - up-regulation of protein localisation to nucleus - up-regulation of protein localization in cell nucleus - up-regulation of protein localization in nucleus - up-regulation of protein localization to nucleus - upregulation of protein localisation to nucleus - upregulation of protein localization in cell nucleus - upregulation of protein localization in nucleus - upregulation of protein localization to nucleus - activation of protein localisation to nucleus - activation of protein localization in cell nucleus - activation of protein localization to nucleus - biological_process - GO:1900182 - positive regulation of protein localization to nucleus - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. - GOC:TermGenie - - - - - activation of protein localization in nucleus - GOC:TermGenie - - - - - positive regulation of protein localisation to nucleus - GOC:TermGenie - - - - - positive regulation of protein localization in cell nucleus - GOC:TermGenie - - - - - positive regulation of protein localization in nucleus - GOC:TermGenie - - - - - up regulation of protein localisation to nucleus - GOC:TermGenie - - - - - up regulation of protein localization in cell nucleus - GOC:TermGenie - - - - - up regulation of protein localization in nucleus - GOC:TermGenie - - - - - up regulation of protein localization to nucleus - GOC:TermGenie - - - - - up-regulation of protein localisation to nucleus - GOC:TermGenie - - - - - up-regulation of protein localization in cell nucleus - GOC:TermGenie - - - - - up-regulation of protein localization in nucleus - GOC:TermGenie - - - - - up-regulation of protein localization to nucleus - GOC:TermGenie - - - - - upregulation of protein localisation to nucleus - GOC:TermGenie - - - - - upregulation of protein localization in cell nucleus - GOC:TermGenie - - - - - upregulation of protein localization in nucleus - GOC:TermGenie - - - - - upregulation of protein localization to nucleus - GOC:TermGenie - - - - - activation of protein localisation to nucleus - GOC:TermGenie - - - - - activation of protein localization in cell nucleus - GOC:TermGenie - - - - - activation of protein localization to nucleus - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of oocyte maturation. - kmv - 2012-03-19T09:41:18Z - biological_process - GO:1900193 - regulation of oocyte maturation - - - - - Any process that modulates the frequency, rate or extent of oocyte maturation. - GOC:TermGenie - GOC:kmv - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation. - kmv - 2012-03-19T09:41:27Z - down regulation of oocyte maturation - down-regulation of oocyte maturation - downregulation of oocyte maturation - inhibition of oocyte maturation - biological_process - GO:1900194 - negative regulation of oocyte maturation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation. - GOC:TermGenie - GOC:kmv - - - - - down regulation of oocyte maturation - GOC:TermGenie - - - - - down-regulation of oocyte maturation - GOC:TermGenie - - - - - downregulation of oocyte maturation - GOC:TermGenie - - - - - inhibition of oocyte maturation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of oocyte maturation. - kmv - 2012-03-19T09:41:35Z - up regulation of oocyte maturation - up-regulation of oocyte maturation - upregulation of oocyte maturation - activation of oocyte maturation - biological_process - GO:1900195 - positive regulation of oocyte maturation - - - - - Any process that activates or increases the frequency, rate or extent of oocyte maturation. - GOC:TermGenie - GOC:kmv - - - - - up regulation of oocyte maturation - GOC:TermGenie - - - - - up-regulation of oocyte maturation - GOC:TermGenie - - - - - upregulation of oocyte maturation - GOC:TermGenie - - - - - activation of oocyte maturation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process. - di - 2012-04-17T01:55:23Z - regulation of secondary metabolite biosynthesis - biological_process - GO:1900376 - regulation of secondary metabolite biosynthetic process - - - - - Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process. - GOC:TermGenie - GOC:di - - - - - regulation of secondary metabolite biosynthesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process. - di - 2012-04-17T01:55:32Z - down regulation of secondary metabolite biosynthesis - down regulation of secondary metabolite biosynthetic process - down-regulation of secondary metabolite biosynthesis - down-regulation of secondary metabolite biosynthetic process - downregulation of secondary metabolite biosynthesis - downregulation of secondary metabolite biosynthetic process - inhibition of secondary metabolite biosynthesis - negative regulation of secondary metabolite biosynthesis - inhibition of secondary metabolite biosynthetic process - biological_process - GO:1900377 - negative regulation of secondary metabolite biosynthetic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process. - GOC:TermGenie - GOC:di - - - - - down regulation of secondary metabolite biosynthesis - GOC:TermGenie - - - - - down regulation of secondary metabolite biosynthetic process - GOC:TermGenie - - - - - down-regulation of secondary metabolite biosynthesis - GOC:TermGenie - - - - - down-regulation of secondary metabolite biosynthetic process - GOC:TermGenie - - - - - downregulation of secondary metabolite biosynthesis - GOC:TermGenie - - - - - downregulation of secondary metabolite biosynthetic process - GOC:TermGenie - - - - - inhibition of secondary metabolite biosynthesis - GOC:TermGenie - - - - - negative regulation of secondary metabolite biosynthesis - GOC:TermGenie - - - - - inhibition of secondary metabolite biosynthetic process - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process. - di - 2012-04-17T01:55:41Z - activation of secondary metabolite biosynthesis - positive regulation of secondary metabolite biosynthesis - up regulation of secondary metabolite biosynthesis - up regulation of secondary metabolite biosynthetic process - up-regulation of secondary metabolite biosynthesis - up-regulation of secondary metabolite biosynthetic process - upregulation of secondary metabolite biosynthesis - upregulation of secondary metabolite biosynthetic process - activation of secondary metabolite biosynthetic process - biological_process - GO:1900378 - positive regulation of secondary metabolite biosynthetic process - - - - - Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process. - GOC:TermGenie - GOC:di - - - - - activation of secondary metabolite biosynthesis - GOC:TermGenie - - - - - positive regulation of secondary metabolite biosynthesis - GOC:TermGenie - - - - - up regulation of secondary metabolite biosynthesis - GOC:TermGenie - - - - - up regulation of secondary metabolite biosynthetic process - GOC:TermGenie - - - - - up-regulation of secondary metabolite biosynthesis - GOC:TermGenie - - - - - up-regulation of secondary metabolite biosynthetic process - GOC:TermGenie - - - - - upregulation of secondary metabolite biosynthesis - GOC:TermGenie - - - - - upregulation of secondary metabolite biosynthetic process - GOC:TermGenie - - - - - activation of secondary metabolite biosynthetic process - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid. - bf - 2012-05-16T12:29:51Z - acetate ester metabolism - acetyl ester metabolic process - acetyl ester metabolism - biological_process - GO:1900619 - acetate ester metabolic process - - - - - The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid. - GOC:TermGenie - - - - - acetate ester metabolism - GOC:TermGenie - - - - - acetyl ester metabolic process - CHEBI:47622 - - - - - acetyl ester metabolism - CHEBI:47622 - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of an acetate esteran acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid. - bf - 2012-05-16T12:30:12Z - acetate ester anabolism - acetate ester biosynthesis - acetate ester formation - acetate ester synthesis - acetyl ester biosynthesis - acetyl ester biosynthetic process - biological_process - GO:1900620 - acetate ester biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of an acetate esteran acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid. - GOC:TermGenie - PMID:15042596 - - - - - acetate ester anabolism - GOC:TermGenie - - - - - acetate ester biosynthesis - GOC:TermGenie - - - - - acetate ester formation - GOC:TermGenie - - - - - acetate ester synthesis - GOC:TermGenie - - - - - acetyl ester biosynthesis - CHEBI:47622 - - - - - acetyl ester biosynthetic process - CHEBI:47622 - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving carbohydrate derivative. - bf - 2012-07-12T04:05:09Z - carbohydrate derivative metabolism - biological_process - GO:1901135 - - - - - carbohydrate derivative metabolic process - - - - - The chemical reactions and pathways involving carbohydrate derivative. - GOC:TermGenie - - - - - carbohydrate derivative metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative. - bf - 2012-07-12T04:05:31Z - carbohydrate derivative breakdown - carbohydrate derivative catabolism - carbohydrate derivative degradation - biological_process - GO:1901136 - carbohydrate derivative catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative. - GOC:TermGenie - - - - - carbohydrate derivative breakdown - GOC:TermGenie - - - - - carbohydrate derivative catabolism - GOC:TermGenie - - - - - carbohydrate derivative degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of carbohydrate derivative. - bf - 2012-07-12T04:05:39Z - carbohydrate derivative anabolism - carbohydrate derivative biosynthesis - carbohydrate derivative formation - carbohydrate derivative synthesis - biological_process - GO:1901137 - carbohydrate derivative biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of carbohydrate derivative. - GOC:TermGenie - - - - - carbohydrate derivative anabolism - GOC:TermGenie - - - - - carbohydrate derivative biosynthesis - GOC:TermGenie - - - - - carbohydrate derivative formation - GOC:TermGenie - - - - - carbohydrate derivative synthesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving insulin. - - pm - 2012-07-13T12:32:40Z - insulin metabolism - biological_process - GO:1901142 - insulin metabolic process - - - - - The chemical reactions and pathways involving insulin. - GOC:TermGenie - - - - - insulin metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of insulin. - pm - 2012-07-13T12:33:03Z - insulin breakdown - insulin catabolism - insulin degradation - biological_process - GO:1901143 - insulin catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of insulin. - GOC:TermGenie - - - - - insulin breakdown - GOC:TermGenie - - - - - insulin catabolism - GOC:TermGenie - - - - - insulin degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form. - bf - 2012-07-16T03:29:30Z - expression of extracellular matrix proteins - biological_process - extracellular matrix protein production - GO:1901148 - gene expression involved in extracellular matrix organization - - - - - Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form. - GOC:TermGenie - GOC:pg - PMID:18668558 - - - - - expression of extracellular matrix proteins - GOC:bf - - - - - extracellular matrix protein production - GOC:pg - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving primary amino compound. - bf - 2012-07-18T04:44:39Z - primary amino compound metabolism - biological_process - GO:1901160 - primary amino compound metabolic process - - - - - The chemical reactions and pathways involving primary amino compound. - GOC:TermGenie - - - - - primary amino compound metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of primary amino compound. - bf - 2012-07-18T04:45:06Z - primary amino compound breakdown - primary amino compound catabolism - primary amino compound degradation - biological_process - GO:1901161 - primary amino compound catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of primary amino compound. - GOC:TermGenie - - - - - primary amino compound breakdown - GOC:TermGenie - - - - - primary amino compound catabolism - GOC:TermGenie - - - - - primary amino compound degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of primary amino compound. - bf - 2012-07-18T04:45:14Z - primary amino compound anabolism - primary amino compound biosynthesis - primary amino compound formation - primary amino compound synthesis - biological_process - GO:1901162 - primary amino compound biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of primary amino compound. - GOC:TermGenie - - - - - primary amino compound anabolism - GOC:TermGenie - - - - - primary amino compound biosynthesis - GOC:TermGenie - - - - - primary amino compound formation - GOC:TermGenie - - - - - primary amino compound synthesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex. - ss - 2012-07-25T02:26:58Z - regulation of translation initiation ternary complex assembly - biological_process - GO:1901190 - regulation of formation of translation initiation ternary complex - - - - - Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex. - GOC:TermGenie - - - - - regulation of translation initiation ternary complex assembly - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex. - ss - 2012-07-25T02:27:21Z - down regulation of formation of translation initiation ternary complex - down regulation of translation initiation ternary complex assembly - down-regulation of formation of translation initiation ternary complex - down-regulation of translation initiation ternary complex assembly - downregulation of formation of translation initiation ternary complex - downregulation of translation initiation ternary complex assembly - inhibition of translation initiation ternary complex assembly - negative regulation of translation initiation ternary complex assembly - inhibition of formation of translation initiation ternary complex - biological_process - GO:1901191 - negative regulation of formation of translation initiation ternary complex - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex. - GOC:TermGenie - - - - - down regulation of formation of translation initiation ternary complex - GOC:TermGenie - - - - - down regulation of translation initiation ternary complex assembly - GOC:TermGenie - - - - - down-regulation of formation of translation initiation ternary complex - GOC:TermGenie - - - - - down-regulation of translation initiation ternary complex assembly - GOC:TermGenie - - - - - downregulation of formation of translation initiation ternary complex - GOC:TermGenie - - - - - downregulation of translation initiation ternary complex assembly - GOC:TermGenie - - - - - inhibition of translation initiation ternary complex assembly - GOC:TermGenie - - - - - negative regulation of translation initiation ternary complex assembly - GOC:TermGenie - - - - - inhibition of formation of translation initiation ternary complex - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex. - ss - 2012-07-25T02:27:29Z - activation of translation initiation ternary complex assembly - positive regulation of translation initiation ternary complex assembly - up regulation of formation of translation initiation ternary complex - up regulation of translation initiation ternary complex assembly - up-regulation of formation of translation initiation ternary complex - up-regulation of translation initiation ternary complex assembly - upregulation of formation of translation initiation ternary complex - upregulation of translation initiation ternary complex assembly - activation of formation of translation initiation ternary complex - biological_process - GO:1901192 - positive regulation of formation of translation initiation ternary complex - - - - - Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex. - GOC:TermGenie - - - - - activation of translation initiation ternary complex assembly - GOC:TermGenie - - - - - positive regulation of translation initiation ternary complex assembly - GOC:TermGenie - - - - - up regulation of formation of translation initiation ternary complex - GOC:TermGenie - - - - - up regulation of translation initiation ternary complex assembly - GOC:TermGenie - - - - - up-regulation of formation of translation initiation ternary complex - GOC:TermGenie - - - - - up-regulation of translation initiation ternary complex assembly - GOC:TermGenie - - - - - upregulation of formation of translation initiation ternary complex - GOC:TermGenie - - - - - upregulation of translation initiation ternary complex assembly - GOC:TermGenie - - - - - activation of formation of translation initiation ternary complex - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of extracellular matrix assembly. - rl - 2012-07-27T04:04:00Z - biological_process - GO:1901201 - regulation of extracellular matrix assembly - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of extracellular matrix assembly. - GOC:BHF - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly. - rl - 2012-07-27T04:04:24Z - down regulation of extracellular matrix assembly - down-regulation of extracellular matrix assembly - downregulation of extracellular matrix assembly - inhibition of extracellular matrix assembly - biological_process - GO:1901202 - negative regulation of extracellular matrix assembly - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly. - GOC:BHF - GOC:TermGenie - - - - - down regulation of extracellular matrix assembly - GOC:TermGenie - - - - - down-regulation of extracellular matrix assembly - GOC:TermGenie - - - - - downregulation of extracellular matrix assembly - GOC:TermGenie - - - - - inhibition of extracellular matrix assembly - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly. - rl - 2012-07-27T04:04:32Z - up regulation of extracellular matrix assembly - up-regulation of extracellular matrix assembly - upregulation of extracellular matrix assembly - activation of extracellular matrix assembly - biological_process - GO:1901203 - positive regulation of extracellular matrix assembly - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly. - GOC:BHF - GOC:TermGenie - - - - - up regulation of extracellular matrix assembly - GOC:TermGenie - - - - - up-regulation of extracellular matrix assembly - GOC:TermGenie - - - - - upregulation of extracellular matrix assembly - GOC:TermGenie - - - - - activation of extracellular matrix assembly - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cardiac chamber formation. - rl - 2012-07-31T07:18:35Z - regulation of heart chamber formation - biological_process - GO:1901210 - regulation of cardiac chamber formation - - - - - Any process that modulates the frequency, rate or extent of cardiac chamber formation. - GOC:BHF - GOC:TermGenie - - - - - regulation of heart chamber formation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation. - rl - 2012-07-31T07:18:57Z - down regulation of cardiac chamber formation - down regulation of heart chamber formation - down-regulation of cardiac chamber formation - down-regulation of heart chamber formation - downregulation of cardiac chamber formation - downregulation of heart chamber formation - inhibition of heart chamber formation - negative regulation of heart chamber formation - inhibition of cardiac chamber formation - biological_process - GO:1901211 - negative regulation of cardiac chamber formation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation. - GOC:BHF - GOC:TermGenie - - - - - down regulation of cardiac chamber formation - GOC:TermGenie - - - - - down regulation of heart chamber formation - GOC:TermGenie - - - - - down-regulation of cardiac chamber formation - GOC:TermGenie - - - - - down-regulation of heart chamber formation - GOC:TermGenie - - - - - downregulation of cardiac chamber formation - GOC:TermGenie - - - - - downregulation of heart chamber formation - GOC:TermGenie - - - - - inhibition of heart chamber formation - GOC:TermGenie - - - - - negative regulation of heart chamber formation - GOC:TermGenie - - - - - inhibition of cardiac chamber formation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cardiac chamber formation. - rl - 2012-07-31T07:19:05Z - activation of heart chamber formation - positive regulation of heart chamber formation - up regulation of cardiac chamber formation - up regulation of heart chamber formation - up-regulation of cardiac chamber formation - up-regulation of heart chamber formation - upregulation of cardiac chamber formation - upregulation of heart chamber formation - activation of cardiac chamber formation - biological_process - GO:1901212 - positive regulation of cardiac chamber formation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of cardiac chamber formation. - GOC:BHF - GOC:TermGenie - - - - - activation of heart chamber formation - GOC:TermGenie - - - - - positive regulation of heart chamber formation - GOC:TermGenie - - - - - up regulation of cardiac chamber formation - GOC:TermGenie - - - - - up regulation of heart chamber formation - GOC:TermGenie - - - - - up-regulation of cardiac chamber formation - GOC:TermGenie - - - - - up-regulation of heart chamber formation - GOC:TermGenie - - - - - upregulation of cardiac chamber formation - GOC:TermGenie - - - - - upregulation of heart chamber formation - GOC:TermGenie - - - - - activation of cardiac chamber formation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis. - rl - 2012-08-06T17:59:11Z - regulation of heart chamber morphogenesis - biological_process - GO:1901219 - regulation of cardiac chamber morphogenesis - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis. - GOC:BHF - GOC:TermGenie - - - - - regulation of heart chamber morphogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis. - rl - 2012-08-06T17:59:34Z - down regulation of cardiac chamber morphogenesis - down regulation of heart chamber morphogenesis - down-regulation of cardiac chamber morphogenesis - down-regulation of heart chamber morphogenesis - downregulation of cardiac chamber morphogenesis - downregulation of heart chamber morphogenesis - negative regulation of heart chamber morphogenesis - inhibition of cardiac chamber morphogenesis - inhibition of heart chamber morphogenesis - biological_process - GO:1901220 - negative regulation of cardiac chamber morphogenesis - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis. - GOC:BHF - GOC:TermGenie - - - - - down regulation of cardiac chamber morphogenesis - GOC:TermGenie - - - - - down regulation of heart chamber morphogenesis - GOC:TermGenie - - - - - down-regulation of cardiac chamber morphogenesis - GOC:TermGenie - - - - - down-regulation of heart chamber morphogenesis - GOC:TermGenie - - - - - downregulation of cardiac chamber morphogenesis - GOC:TermGenie - - - - - downregulation of heart chamber morphogenesis - GOC:TermGenie - - - - - negative regulation of heart chamber morphogenesis - GOC:TermGenie - - - - - inhibition of cardiac chamber morphogenesis - GOC:TermGenie - - - - - inhibition of heart chamber morphogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis. - rl - 2012-08-06T17:59:42Z - positive regulation of heart chamber morphogenesis - up regulation of cardiac chamber morphogenesis - up regulation of heart chamber morphogenesis - up-regulation of cardiac chamber morphogenesis - up-regulation of heart chamber morphogenesis - upregulation of cardiac chamber morphogenesis - upregulation of heart chamber morphogenesis - activation of cardiac chamber morphogenesis - activation of heart chamber morphogenesis - biological_process - GO:1901221 - positive regulation of cardiac chamber morphogenesis - - - - - Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis. - GOC:BHF - GOC:TermGenie - - - - - positive regulation of heart chamber morphogenesis - GOC:TermGenie - - - - - up regulation of cardiac chamber morphogenesis - GOC:TermGenie - - - - - up regulation of heart chamber morphogenesis - GOC:TermGenie - - - - - up-regulation of cardiac chamber morphogenesis - GOC:TermGenie - - - - - up-regulation of heart chamber morphogenesis - GOC:TermGenie - - - - - upregulation of cardiac chamber morphogenesis - GOC:TermGenie - - - - - upregulation of heart chamber morphogenesis - GOC:TermGenie - - - - - activation of cardiac chamber morphogenesis - GOC:TermGenie - - - - - activation of heart chamber morphogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation. - vk - 2012-08-08T08:58:34Z - biological_process - GO:1901246 - regulation of lung ciliated cell differentiation - - - - - Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation. - GOC:BHF - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation. - vk - 2012-08-08T08:58:58Z - down regulation of lung ciliated cell differentiation - down-regulation of lung ciliated cell differentiation - downregulation of lung ciliated cell differentiation - inhibition of lung ciliated cell differentiation - biological_process - GO:1901247 - negative regulation of lung ciliated cell differentiation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation. - GOC:BHF - GOC:TermGenie - - - - - down regulation of lung ciliated cell differentiation - GOC:TermGenie - - - - - down-regulation of lung ciliated cell differentiation - GOC:TermGenie - - - - - downregulation of lung ciliated cell differentiation - GOC:TermGenie - - - - - inhibition of lung ciliated cell differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation. - vk - 2012-08-08T08:59:05Z - up regulation of lung ciliated cell differentiation - up-regulation of lung ciliated cell differentiation - upregulation of lung ciliated cell differentiation - activation of lung ciliated cell differentiation - biological_process - GO:1901248 - positive regulation of lung ciliated cell differentiation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation. - GOC:BHF - GOC:TermGenie - - - - - up regulation of lung ciliated cell differentiation - GOC:TermGenie - - - - - up-regulation of lung ciliated cell differentiation - GOC:TermGenie - - - - - upregulation of lung ciliated cell differentiation - GOC:TermGenie - - - - - activation of lung ciliated cell differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - bf - 2012-08-16T14:51:22Z - biological_process - GO:1901264 - carbohydrate derivative transport - - - - - The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:TermGenie - GOC:bf - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of vasculature development. - bf - 2012-09-06T09:16:15Z - biological_process - regulation of vascular system development - GO:1901342 - regulation of vasculature development - - - - - Any process that modulates the frequency, rate or extent of vasculature development. - GOC:TermGenie - - - - - regulation of vascular system development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. - bf - 2012-09-06T09:17:24Z - down regulation of vasculature development - down-regulation of vasculature development - downregulation of vasculature development - inhibition of vasculature development - biological_process - down regulation of vascular system development - down-regulation of vascular system development - downregulation of vascular system development - inhibition of vascular system development - negative regulation of vascular system development - GO:1901343 - negative regulation of vasculature development - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. - GOC:TermGenie - - - - - down regulation of vasculature development - GOC:TermGenie - - - - - down-regulation of vasculature development - GOC:TermGenie - - - - - downregulation of vasculature development - GOC:TermGenie - - - - - inhibition of vasculature development - GOC:TermGenie - - - - - down regulation of vascular system development - GOC:TermGenie - - - - - down-regulation of vascular system development - GOC:TermGenie - - - - - downregulation of vascular system development - GOC:TermGenie - - - - - inhibition of vascular system development - GOC:TermGenie - - - - - negative regulation of vascular system development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving organic cyclic compound. - bf - 2012-09-14T09:03:51Z - organic cyclic compound metabolism - biological_process - GO:1901360 - organic cyclic compound metabolic process - - - - - The chemical reactions and pathways involving organic cyclic compound. - GOC:TermGenie - - - - - organic cyclic compound metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. - bf - 2012-09-14T09:05:04Z - organic cyclic compound breakdown - organic cyclic compound catabolism - organic cyclic compound degradation - biological_process - GO:1901361 - organic cyclic compound catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. - GOC:TermGenie - - - - - organic cyclic compound breakdown - GOC:TermGenie - - - - - organic cyclic compound catabolism - GOC:TermGenie - - - - - organic cyclic compound degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of organic cyclic compound. - bf - 2012-09-14T09:05:22Z - organic cyclic compound anabolism - organic cyclic compound biosynthesis - organic cyclic compound formation - organic cyclic compound synthesis - biological_process - GO:1901362 - organic cyclic compound biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of organic cyclic compound. - GOC:TermGenie - - - - - organic cyclic compound anabolism - GOC:TermGenie - - - - - organic cyclic compound biosynthesis - GOC:TermGenie - - - - - organic cyclic compound formation - GOC:TermGenie - - - - - organic cyclic compound synthesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - bf - 2012-09-28T10:42:13Z - biological_process - GO:1901374 - acetate ester transport - - - - - The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of an acetate ester from one side of a membrane to the other. - bf - 2012-09-28T10:47:08Z - molecular_function - GO:1901375 - acetate ester transmembrane transporter activity - - - - - Enables the transfer of an acetate ester from one side of a membrane to the other. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process. - tt - 2012-10-01T14:34:03Z - regulation of tetrapyrrole metabolism - biological_process - GO:1901401 - regulation of tetrapyrrole metabolic process - - - - - Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process. - GOC:TermGenie - GOC:mengo_curators - - - - - regulation of tetrapyrrole metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole metabolic process. - tt - 2012-10-01T14:35:11Z - down regulation of tetrapyrrole metabolic process - down regulation of tetrapyrrole metabolism - down-regulation of tetrapyrrole metabolic process - down-regulation of tetrapyrrole metabolism - downregulation of tetrapyrrole metabolic process - downregulation of tetrapyrrole metabolism - inhibition of tetrapyrrole metabolism - negative regulation of tetrapyrrole metabolism - inhibition of tetrapyrrole metabolic process - biological_process - GO:1901402 - negative regulation of tetrapyrrole metabolic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole metabolic process. - GOC:TermGenie - GOC:mengo_curators - - - - - down regulation of tetrapyrrole metabolic process - GOC:TermGenie - - - - - down regulation of tetrapyrrole metabolism - GOC:TermGenie - - - - - down-regulation of tetrapyrrole metabolic process - GOC:TermGenie - - - - - down-regulation of tetrapyrrole metabolism - GOC:TermGenie - - - - - downregulation of tetrapyrrole metabolic process - GOC:TermGenie - - - - - downregulation of tetrapyrrole metabolism - GOC:TermGenie - - - - - inhibition of tetrapyrrole metabolism - GOC:TermGenie - - - - - negative regulation of tetrapyrrole metabolism - GOC:TermGenie - - - - - inhibition of tetrapyrrole metabolic process - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of tetrapyrrole metabolic process. - tt - 2012-10-01T14:35:29Z - activation of tetrapyrrole metabolism - positive regulation of tetrapyrrole metabolism - up regulation of tetrapyrrole metabolic process - up regulation of tetrapyrrole metabolism - up-regulation of tetrapyrrole metabolic process - up-regulation of tetrapyrrole metabolism - upregulation of tetrapyrrole metabolic process - upregulation of tetrapyrrole metabolism - activation of tetrapyrrole metabolic process - biological_process - GO:1901403 - positive regulation of tetrapyrrole metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of tetrapyrrole metabolic process. - GOC:TermGenie - GOC:mengo_curators - - - - - activation of tetrapyrrole metabolism - GOC:TermGenie - - - - - positive regulation of tetrapyrrole metabolism - GOC:TermGenie - - - - - up regulation of tetrapyrrole metabolic process - GOC:TermGenie - - - - - up regulation of tetrapyrrole metabolism - GOC:TermGenie - - - - - up-regulation of tetrapyrrole metabolic process - GOC:TermGenie - - - - - up-regulation of tetrapyrrole metabolism - GOC:TermGenie - - - - - upregulation of tetrapyrrole metabolic process - GOC:TermGenie - - - - - upregulation of tetrapyrrole metabolism - GOC:TermGenie - - - - - activation of tetrapyrrole metabolic process - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of tetrapyrrole catabolic process. - tt - 2012-10-01T14:38:12Z - regulation of tetrapyrrole breakdown - regulation of tetrapyrrole catabolism - regulation of tetrapyrrole degradation - biological_process - GO:1901404 - regulation of tetrapyrrole catabolic process - - - - - Any process that modulates the frequency, rate or extent of tetrapyrrole catabolic process. - GOC:TermGenie - GOC:mengo_curators - - - - - regulation of tetrapyrrole breakdown - GOC:TermGenie - - - - - regulation of tetrapyrrole catabolism - GOC:TermGenie - - - - - regulation of tetrapyrrole degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole catabolic process. - tt - 2012-10-01T14:39:22Z - down regulation of tetrapyrrole breakdown - down regulation of tetrapyrrole catabolic process - down regulation of tetrapyrrole catabolism - down regulation of tetrapyrrole degradation - down-regulation of tetrapyrrole breakdown - down-regulation of tetrapyrrole catabolic process - down-regulation of tetrapyrrole catabolism - down-regulation of tetrapyrrole degradation - downregulation of tetrapyrrole breakdown - downregulation of tetrapyrrole catabolic process - downregulation of tetrapyrrole catabolism - downregulation of tetrapyrrole degradation - inhibition of tetrapyrrole breakdown - inhibition of tetrapyrrole catabolism - inhibition of tetrapyrrole degradation - negative regulation of tetrapyrrole breakdown - negative regulation of tetrapyrrole catabolism - negative regulation of tetrapyrrole degradation - inhibition of tetrapyrrole catabolic process - biological_process - GO:1901405 - negative regulation of tetrapyrrole catabolic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole catabolic process. - GOC:TermGenie - GOC:mengo_curators - - - - - down regulation of tetrapyrrole breakdown - GOC:TermGenie - - - - - down regulation of tetrapyrrole catabolic process - GOC:TermGenie - - - - - down regulation of tetrapyrrole catabolism - GOC:TermGenie - - - - - down regulation of tetrapyrrole degradation - GOC:TermGenie - - - - - down-regulation of tetrapyrrole breakdown - GOC:TermGenie - - - - - down-regulation of tetrapyrrole catabolic process - GOC:TermGenie - - - - - down-regulation of tetrapyrrole catabolism - GOC:TermGenie - - - - - down-regulation of tetrapyrrole degradation - GOC:TermGenie - - - - - downregulation of tetrapyrrole breakdown - GOC:TermGenie - - - - - downregulation of tetrapyrrole catabolic process - GOC:TermGenie - - - - - downregulation of tetrapyrrole catabolism - GOC:TermGenie - - - - - downregulation of tetrapyrrole degradation - GOC:TermGenie - - - - - inhibition of tetrapyrrole breakdown - GOC:TermGenie - - - - - inhibition of tetrapyrrole catabolism - GOC:TermGenie - - - - - inhibition of tetrapyrrole degradation - GOC:TermGenie - - - - - negative regulation of tetrapyrrole breakdown - GOC:TermGenie - - - - - negative regulation of tetrapyrrole catabolism - GOC:TermGenie - - - - - negative regulation of tetrapyrrole degradation - GOC:TermGenie - - - - - inhibition of tetrapyrrole catabolic process - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of tetrapyrrole catabolic process. - tt - 2012-10-01T14:39:40Z - activation of tetrapyrrole breakdown - activation of tetrapyrrole catabolism - activation of tetrapyrrole degradation - positive regulation of tetrapyrrole breakdown - positive regulation of tetrapyrrole catabolism - positive regulation of tetrapyrrole degradation - up regulation of tetrapyrrole breakdown - up regulation of tetrapyrrole catabolic process - up regulation of tetrapyrrole catabolism - up regulation of tetrapyrrole degradation - up-regulation of tetrapyrrole breakdown - up-regulation of tetrapyrrole catabolic process - up-regulation of tetrapyrrole catabolism - up-regulation of tetrapyrrole degradation - upregulation of tetrapyrrole breakdown - upregulation of tetrapyrrole catabolic process - upregulation of tetrapyrrole catabolism - upregulation of tetrapyrrole degradation - activation of tetrapyrrole catabolic process - biological_process - GO:1901406 - positive regulation of tetrapyrrole catabolic process - - - - - Any process that activates or increases the frequency, rate or extent of tetrapyrrole catabolic process. - GOC:TermGenie - GOC:mengo_curators - - - - - activation of tetrapyrrole breakdown - GOC:TermGenie - - - - - activation of tetrapyrrole catabolism - GOC:TermGenie - - - - - activation of tetrapyrrole degradation - GOC:TermGenie - - - - - positive regulation of tetrapyrrole breakdown - GOC:TermGenie - - - - - positive regulation of tetrapyrrole catabolism - GOC:TermGenie - - - - - positive regulation of tetrapyrrole degradation - GOC:TermGenie - - - - - up regulation of tetrapyrrole breakdown - GOC:TermGenie - - - - - up regulation of tetrapyrrole catabolic process - GOC:TermGenie - - - - - up regulation of tetrapyrrole catabolism - GOC:TermGenie - - - - - up regulation of tetrapyrrole degradation - GOC:TermGenie - - - - - up-regulation of tetrapyrrole breakdown - GOC:TermGenie - - - - - up-regulation of tetrapyrrole catabolic process - GOC:TermGenie - - - - - up-regulation of tetrapyrrole catabolism - GOC:TermGenie - - - - - up-regulation of tetrapyrrole degradation - GOC:TermGenie - - - - - upregulation of tetrapyrrole breakdown - GOC:TermGenie - - - - - upregulation of tetrapyrrole catabolic process - GOC:TermGenie - - - - - upregulation of tetrapyrrole catabolism - GOC:TermGenie - - - - - upregulation of tetrapyrrole degradation - GOC:TermGenie - - - - - activation of tetrapyrrole catabolic process - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of response to acetate. - tt - 2012-10-02T14:25:06Z - biological_process - GO:1901457 - regulation of response to acetate - - - - - Any process that modulates the frequency, rate or extent of response to acetate. - GOC:TermGenie - GOC:mengo_curators - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of response to acetate. - tt - 2012-10-02T14:26:15Z - down regulation of response to acetate - down-regulation of response to acetate - downregulation of response to acetate - inhibition of response to acetate - biological_process - GO:1901458 - negative regulation of response to acetate - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of response to acetate. - GOC:TermGenie - GOC:mengo_curators - - - - - down regulation of response to acetate - GOC:TermGenie - - - - - down-regulation of response to acetate - GOC:TermGenie - - - - - downregulation of response to acetate - GOC:TermGenie - - - - - inhibition of response to acetate - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of response to acetate. - tt - 2012-10-02T14:26:34Z - up regulation of response to acetate - up-regulation of response to acetate - upregulation of response to acetate - activation of response to acetate - biological_process - GO:1901459 - positive regulation of response to acetate - - - - - Any process that activates or increases the frequency, rate or extent of response to acetate. - GOC:TermGenie - GOC:mengo_curators - - - - - up regulation of response to acetate - GOC:TermGenie - - - - - up-regulation of response to acetate - GOC:TermGenie - - - - - upregulation of response to acetate - GOC:TermGenie - - - - - activation of response to acetate - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process. - tt - 2012-10-02T14:34:14Z - regulation of tetrapyrrole anabolism - regulation of tetrapyrrole biosynthesis - regulation of tetrapyrrole formation - regulation of tetrapyrrole synthesis - biological_process - GO:1901463 - regulation of tetrapyrrole biosynthetic process - - - - - Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process. - GOC:TermGenie - GOC:mengo_curators - - - - - regulation of tetrapyrrole anabolism - GOC:TermGenie - - - - - regulation of tetrapyrrole biosynthesis - GOC:TermGenie - - - - - regulation of tetrapyrrole formation - GOC:TermGenie - - - - - regulation of tetrapyrrole synthesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process. - tt - 2012-10-02T14:35:26Z - down regulation of tetrapyrrole anabolism - down regulation of tetrapyrrole biosynthesis - down regulation of tetrapyrrole biosynthetic process - down regulation of tetrapyrrole formation - down regulation of tetrapyrrole synthesis - down-regulation of tetrapyrrole anabolism - down-regulation of tetrapyrrole biosynthesis - down-regulation of tetrapyrrole biosynthetic process - down-regulation of tetrapyrrole formation - down-regulation of tetrapyrrole synthesis - downregulation of tetrapyrrole anabolism - downregulation of tetrapyrrole biosynthesis - downregulation of tetrapyrrole biosynthetic process - downregulation of tetrapyrrole formation - downregulation of tetrapyrrole synthesis - inhibition of tetrapyrrole anabolism - inhibition of tetrapyrrole biosynthesis - inhibition of tetrapyrrole formation - inhibition of tetrapyrrole synthesis - negative regulation of tetrapyrrole anabolism - negative regulation of tetrapyrrole biosynthesis - negative regulation of tetrapyrrole formation - negative regulation of tetrapyrrole synthesis - inhibition of tetrapyrrole biosynthetic process - biological_process - GO:1901464 - negative regulation of tetrapyrrole biosynthetic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process. - GOC:TermGenie - GOC:mengo_curators - - - - - down regulation of tetrapyrrole anabolism - GOC:TermGenie - - - - - down regulation of tetrapyrrole biosynthesis - GOC:TermGenie - - - - - down regulation of tetrapyrrole biosynthetic process - GOC:TermGenie - - - - - down regulation of tetrapyrrole formation - GOC:TermGenie - - - - - down regulation of tetrapyrrole synthesis - GOC:TermGenie - - - - - down-regulation of tetrapyrrole anabolism - GOC:TermGenie - - - - - down-regulation of tetrapyrrole biosynthesis - GOC:TermGenie - - - - - down-regulation of tetrapyrrole biosynthetic process - GOC:TermGenie - - - - - down-regulation of tetrapyrrole formation - GOC:TermGenie - - - - - down-regulation of tetrapyrrole synthesis - GOC:TermGenie - - - - - downregulation of tetrapyrrole anabolism - GOC:TermGenie - - - - - downregulation of tetrapyrrole biosynthesis - GOC:TermGenie - - - - - downregulation of tetrapyrrole biosynthetic process - GOC:TermGenie - - - - - downregulation of tetrapyrrole formation - GOC:TermGenie - - - - - downregulation of tetrapyrrole synthesis - GOC:TermGenie - - - - - inhibition of tetrapyrrole anabolism - GOC:TermGenie - - - - - inhibition of tetrapyrrole biosynthesis - GOC:TermGenie - - - - - inhibition of tetrapyrrole formation - GOC:TermGenie - - - - - inhibition of tetrapyrrole synthesis - GOC:TermGenie - - - - - negative regulation of tetrapyrrole anabolism - GOC:TermGenie - - - - - negative regulation of tetrapyrrole biosynthesis - GOC:TermGenie - - - - - negative regulation of tetrapyrrole formation - GOC:TermGenie - - - - - negative regulation of tetrapyrrole synthesis - GOC:TermGenie - - - - - inhibition of tetrapyrrole biosynthetic process - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process. - tt - 2012-10-02T14:35:43Z - activation of tetrapyrrole anabolism - activation of tetrapyrrole biosynthesis - activation of tetrapyrrole formation - activation of tetrapyrrole synthesis - positive regulation of tetrapyrrole anabolism - positive regulation of tetrapyrrole biosynthesis - positive regulation of tetrapyrrole formation - positive regulation of tetrapyrrole synthesis - up regulation of tetrapyrrole anabolism - up regulation of tetrapyrrole biosynthesis - up regulation of tetrapyrrole biosynthetic process - up regulation of tetrapyrrole formation - up regulation of tetrapyrrole synthesis - up-regulation of tetrapyrrole anabolism - up-regulation of tetrapyrrole biosynthesis - up-regulation of tetrapyrrole biosynthetic process - up-regulation of tetrapyrrole formation - up-regulation of tetrapyrrole synthesis - upregulation of tetrapyrrole anabolism - upregulation of tetrapyrrole biosynthesis - upregulation of tetrapyrrole biosynthetic process - upregulation of tetrapyrrole formation - upregulation of tetrapyrrole synthesis - activation of tetrapyrrole biosynthetic process - biological_process - GO:1901465 - positive regulation of tetrapyrrole biosynthetic process - - - - - Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process. - GOC:TermGenie - GOC:mengo_curators - - - - - activation of tetrapyrrole anabolism - GOC:TermGenie - - - - - activation of tetrapyrrole biosynthesis - GOC:TermGenie - - - - - activation of tetrapyrrole formation - GOC:TermGenie - - - - - activation of tetrapyrrole synthesis - GOC:TermGenie - - - - - positive regulation of tetrapyrrole anabolism - GOC:TermGenie - - - - - positive regulation of tetrapyrrole biosynthesis - GOC:TermGenie - - - - - positive regulation of tetrapyrrole formation - GOC:TermGenie - - - - - positive regulation of tetrapyrrole synthesis - GOC:TermGenie - - - - - up regulation of tetrapyrrole anabolism - GOC:TermGenie - - - - - up regulation of tetrapyrrole biosynthesis - GOC:TermGenie - - - - - up regulation of tetrapyrrole biosynthetic process - GOC:TermGenie - - - - - up regulation of tetrapyrrole formation - GOC:TermGenie - - - - - up regulation of tetrapyrrole synthesis - GOC:TermGenie - - - - - up-regulation of tetrapyrrole anabolism - GOC:TermGenie - - - - - up-regulation of tetrapyrrole biosynthesis - GOC:TermGenie - - - - - up-regulation of tetrapyrrole biosynthetic process - GOC:TermGenie - - - - - up-regulation of tetrapyrrole formation - GOC:TermGenie - - - - - up-regulation of tetrapyrrole synthesis - GOC:TermGenie - - - - - upregulation of tetrapyrrole anabolism - GOC:TermGenie - - - - - upregulation of tetrapyrrole biosynthesis - GOC:TermGenie - - - - - upregulation of tetrapyrrole biosynthetic process - GOC:TermGenie - - - - - upregulation of tetrapyrrole formation - GOC:TermGenie - - - - - upregulation of tetrapyrrole synthesis - GOC:TermGenie - - - - - activation of tetrapyrrole biosynthetic process - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of carbohydrate derivative from one side of a membrane to the other. - pr - 2012-10-17T10:31:22Z - molecular_function - carbohydrate derivative transporter activity - GO:1901505 - carbohydrate derivative transmembrane transporter activity - - - - - - - - - - - GO_REF:0000090 - - - - - Enables the transfer of carbohydrate derivative from one side of a membrane to the other. - GOC:TermGenie - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis. - dph - 2012-10-17T14:30:40Z - biological_process - GO:1901509 - regulation of endothelial tube morphogenesis - - - - - Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis. - GOC:TermGenie - GOC:dph - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation. - vk - 2012-10-24T11:23:01Z - regulation of haematopoietic progenitor cell differentiation - regulation of haemopoietic progenitor cell differentiation - regulation of hemopoietic progenitor cell differentiation - biological_process - GO:1901532 - regulation of hematopoietic progenitor cell differentiation - - - - - Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation. - GOC:BHF - GOC:TermGenie - GOC:rl - - - - - regulation of haematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - regulation of haemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation. - vk - 2012-10-24T11:23:06Z - down regulation of haematopoietic progenitor cell differentiation - down regulation of haemopoietic progenitor cell differentiation - down regulation of hemopoietic progenitor cell differentiation - down-regulation of haematopoietic progenitor cell differentiation - down-regulation of haemopoietic progenitor cell differentiation - down-regulation of hemopoietic progenitor cell differentiation - downregulation of haematopoietic progenitor cell differentiation - downregulation of haemopoietic progenitor cell differentiation - downregulation of hemopoietic progenitor cell differentiation - inhibition of haematopoietic progenitor cell differentiation - inhibition of haemopoietic progenitor cell differentiation - negative regulation of haematopoietic progenitor cell differentiation - negative regulation of haemopoietic progenitor cell differentiation - negative regulation of hemopoietic progenitor cell differentiation - inhibition of hemopoietic progenitor cell differentiation - biological_process - down regulation of hematopoietic progenitor cell differentiation - down-regulation of hematopoietic progenitor cell differentiation - downregulation of hematopoietic progenitor cell differentiation - inhibition of hematopoietic progenitor cell differentiation - GO:1901533 - negative regulation of hematopoietic progenitor cell differentiation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation. - GOC:BHF - GOC:TermGenie - GOC:rl - - - - - down regulation of haematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - down regulation of haemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - down regulation of hemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - down-regulation of haematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - down-regulation of haemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - down-regulation of hemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - downregulation of haematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - downregulation of haemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - downregulation of hemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - inhibition of haematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - inhibition of haemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - negative regulation of haematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - negative regulation of haemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - inhibition of hemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - down regulation of hematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - down-regulation of hematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - downregulation of hematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - inhibition of hematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation. - vk - 2012-10-24T11:23:14Z - activation of haematopoietic progenitor cell differentiation - activation of haemopoietic progenitor cell differentiation - positive regulation of haematopoietic progenitor cell differentiation - positive regulation of haemopoietic progenitor cell differentiation - positive regulation of hemopoietic progenitor cell differentiation - up regulation of haematopoietic progenitor cell differentiation - up regulation of haemopoietic progenitor cell differentiation - up regulation of hemopoietic progenitor cell differentiation - up-regulation of haematopoietic progenitor cell differentiation - up-regulation of haemopoietic progenitor cell differentiation - up-regulation of hemopoietic progenitor cell differentiation - upregulation of haematopoietic progenitor cell differentiation - upregulation of haemopoietic progenitor cell differentiation - upregulation of hemopoietic progenitor cell differentiation - activation of hemopoietic progenitor cell differentiation - biological_process - activation of hematopoietic progenitor cell differentiation - up regulation of hematopoietic progenitor cell differentiation - up-regulation of hematopoietic progenitor cell differentiation - upregulation of hematopoietic progenitor cell differentiation - GO:1901534 - positive regulation of hematopoietic progenitor cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation. - GOC:BHF - GOC:TermGenie - GOC:rl - - - - - activation of haematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - activation of haemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - positive regulation of haematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - positive regulation of haemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - up regulation of haematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - up regulation of haemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - up regulation of hemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - up-regulation of haematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - up-regulation of haemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - up-regulation of hemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - upregulation of haematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - upregulation of haemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - upregulation of hemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - activation of hemopoietic progenitor cell differentiation - GOC:TermGenie - - - - - activation of hematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - up regulation of hematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - up-regulation of hematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - upregulation of hematopoietic progenitor cell differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of endothelial cell development. - pr - 2012-10-30T12:59:50Z - biological_process - GO:1901550 - regulation of endothelial cell development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of endothelial cell development. - GOC:TermGenie - GOC:pr - PMID:19470579 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development. - pr - 2012-10-30T12:59:54Z - down regulation of endothelial cell development - down-regulation of endothelial cell development - downregulation of endothelial cell development - inhibition of endothelial cell development - biological_process - GO:1901551 - negative regulation of endothelial cell development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development. - GOC:TermGenie - GOC:pr - PMID:19470579 - - - - - down regulation of endothelial cell development - GOC:TermGenie - - - - - down-regulation of endothelial cell development - GOC:TermGenie - - - - - downregulation of endothelial cell development - GOC:TermGenie - - - - - inhibition of endothelial cell development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of endothelial cell development. - pr - 2012-10-30T12:59:58Z - up regulation of endothelial cell development - up-regulation of endothelial cell development - upregulation of endothelial cell development - activation of endothelial cell development - biological_process - GO:1901552 - positive regulation of endothelial cell development - - - - - Any process that activates or increases the frequency, rate or extent of endothelial cell development. - GOC:TermGenie - GOC:pr - PMID:19470579 - - - - - up regulation of endothelial cell development - GOC:TermGenie - - - - - up-regulation of endothelial cell development - GOC:TermGenie - - - - - upregulation of endothelial cell development - GOC:TermGenie - - - - - activation of endothelial cell development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving organonitrogen compound. - pr - 2012-11-04T15:17:52Z - organonitrogen compound metabolism - biological_process - GO:1901564 - organonitrogen compound metabolic process - - - - - The chemical reactions and pathways involving organonitrogen compound. - GOC:TermGenie - GOC:pr - - - - - organonitrogen compound metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. - pr - 2012-11-04T15:17:56Z - organonitrogen compound breakdown - organonitrogen compound catabolism - organonitrogen compound degradation - biological_process - GO:1901565 - organonitrogen compound catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. - GOC:TermGenie - GOC:pr - - - - - organonitrogen compound breakdown - GOC:TermGenie - - - - - organonitrogen compound catabolism - GOC:TermGenie - - - - - organonitrogen compound degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of organonitrogen compound. - pr - 2012-11-04T15:18:00Z - organonitrogen compound anabolism - organonitrogen compound biosynthesis - organonitrogen compound formation - organonitrogen compound synthesis - biological_process - GO:1901566 - organonitrogen compound biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of organonitrogen compound. - GOC:TermGenie - GOC:pr - - - - - organonitrogen compound anabolism - GOC:TermGenie - - - - - organonitrogen compound biosynthesis - GOC:TermGenie - - - - - organonitrogen compound formation - GOC:TermGenie - - - - - organonitrogen compound synthesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon. - pr - 2012-11-05T11:04:36Z - organic molecular entity breakdown - organic molecular entity catabolic process - organic molecular entity catabolism - organic molecular entity degradation - organic substance breakdown - organic substance catabolism - organic substance degradation - biological_process - GO:1901575 - organic substance catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon. - GOC:TermGenie - GOC:pr - - - - - organic molecular entity breakdown - GOC:TermGenie - - - - - organic molecular entity catabolism - GOC:TermGenie - - - - - organic molecular entity degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. - pr - 2012-11-05T11:04:40Z - organic molecular entity anabolism - organic molecular entity biosynthesis - organic molecular entity biosynthetic process - organic molecular entity formation - organic molecular entity synthesis - organic substance anabolism - organic substance biosynthesis - organic substance formation - organic substance synthesis - biological_process - GO:1901576 - organic substance biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. - GOC:TermGenie - GOC:pr - - - - - organic molecular entity anabolism - GOC:TermGenie - - - - - organic molecular entity biosynthesis - GOC:TermGenie - - - - - organic molecular entity formation - GOC:TermGenie - - - - - organic molecular entity synthesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving an alpha-amino acid. - tb - 2012-11-08T17:39:50Z - alpha-amino acid metabolism - biological_process - GO:1901605 - alpha-amino acid metabolic process - - - - - The chemical reactions and pathways involving an alpha-amino acid. - GOC:TermGenie - - - - - alpha-amino acid metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid. - tb - 2012-11-08T17:39:54Z - alpha-amino acid breakdown - alpha-amino acid catabolism - alpha-amino acid degradation - biological_process - GO:1901606 - alpha-amino acid catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid. - GOC:TermGenie - - - - - alpha-amino acid breakdown - GOC:TermGenie - - - - - alpha-amino acid catabolism - GOC:TermGenie - - - - - alpha-amino acid degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of an alpha-amino acid. - tb - 2012-11-08T17:39:58Z - alpha-amino acid anabolism - alpha-amino acid biosynthesis - alpha-amino acid formation - alpha-amino acid synthesis - biological_process - GO:1901607 - alpha-amino acid biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of an alpha-amino acid. - GOC:TermGenie - - - - - alpha-amino acid anabolism - GOC:TermGenie - - - - - alpha-amino acid biosynthesis - GOC:TermGenie - - - - - alpha-amino acid formation - GOC:TermGenie - - - - - alpha-amino acid synthesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of vesicle transport along microtubule. - hjd - 2012-11-08T21:49:44Z - regulation of microtubule-based vesicle localization - biological_process - GO:1901608 - regulation of vesicle transport along microtubule - - - - - Any process that modulates the frequency, rate or extent of vesicle transport along microtubule. - GOC:TermGenie - - - - - regulation of microtubule-based vesicle localization - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule. - hjd - 2012-11-08T21:49:48Z - down regulation of microtubule-based vesicle localization - down regulation of vesicle transport along microtubule - down-regulation of microtubule-based vesicle localization - down-regulation of vesicle transport along microtubule - downregulation of microtubule-based vesicle localization - downregulation of vesicle transport along microtubule - inhibition of microtubule-based vesicle localization - negative regulation of microtubule-based vesicle localization - inhibition of vesicle transport along microtubule - biological_process - GO:1901609 - negative regulation of vesicle transport along microtubule - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule. - GOC:TermGenie - - - - - down regulation of microtubule-based vesicle localization - GOC:TermGenie - - - - - down regulation of vesicle transport along microtubule - GOC:TermGenie - - - - - down-regulation of microtubule-based vesicle localization - GOC:TermGenie - - - - - down-regulation of vesicle transport along microtubule - GOC:TermGenie - - - - - downregulation of microtubule-based vesicle localization - GOC:TermGenie - - - - - downregulation of vesicle transport along microtubule - GOC:TermGenie - - - - - inhibition of microtubule-based vesicle localization - GOC:TermGenie - - - - - negative regulation of microtubule-based vesicle localization - GOC:TermGenie - - - - - inhibition of vesicle transport along microtubule - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule. - hjd - 2012-11-08T21:49:53Z - activation of microtubule-based vesicle localization - positive regulation of microtubule-based vesicle localization - up regulation of microtubule-based vesicle localization - up regulation of vesicle transport along microtubule - up-regulation of microtubule-based vesicle localization - up-regulation of vesicle transport along microtubule - upregulation of microtubule-based vesicle localization - upregulation of vesicle transport along microtubule - activation of vesicle transport along microtubule - biological_process - GO:1901610 - positive regulation of vesicle transport along microtubule - - - - - Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule. - GOC:TermGenie - - - - - activation of microtubule-based vesicle localization - GOC:TermGenie - - - - - positive regulation of microtubule-based vesicle localization - GOC:TermGenie - - - - - up regulation of microtubule-based vesicle localization - GOC:TermGenie - - - - - up regulation of vesicle transport along microtubule - GOC:TermGenie - - - - - up-regulation of microtubule-based vesicle localization - GOC:TermGenie - - - - - up-regulation of vesicle transport along microtubule - GOC:TermGenie - - - - - upregulation of microtubule-based vesicle localization - GOC:TermGenie - - - - - upregulation of vesicle transport along microtubule - GOC:TermGenie - - - - - activation of vesicle transport along microtubule - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving organic hydroxy compound. - pr - 2012-11-13T12:54:27Z - organic hydroxy compound metabolism - biological_process - GO:1901615 - organic hydroxy compound metabolic process - - - - - The chemical reactions and pathways involving organic hydroxy compound. - GOC:TermGenie - GOC:pr - - - - - organic hydroxy compound metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. - pr - 2012-11-13T12:54:31Z - organic hydroxy compound breakdown - organic hydroxy compound catabolism - organic hydroxy compound degradation - biological_process - GO:1901616 - organic hydroxy compound catabolic process - - - - - The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. - GOC:TermGenie - GOC:pr - - - - - organic hydroxy compound breakdown - GOC:TermGenie - - - - - organic hydroxy compound catabolism - GOC:TermGenie - - - - - organic hydroxy compound degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of organic hydroxy compound. - pr - 2012-11-13T12:54:36Z - organic hydroxy compound anabolism - organic hydroxy compound biosynthesis - organic hydroxy compound formation - organic hydroxy compound synthesis - biological_process - GO:1901617 - organic hydroxy compound biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of organic hydroxy compound. - GOC:TermGenie - GOC:pr - - - - - organic hydroxy compound anabolism - GOC:TermGenie - - - - - organic hydroxy compound biosynthesis - GOC:TermGenie - - - - - organic hydroxy compound formation - GOC:TermGenie - - - - - organic hydroxy compound synthesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of organic hydroxy compound from one side of a membrane to the other. - pr - 2012-11-13T12:59:01Z - molecular_function - GO:1901618 - organic hydroxy compound transmembrane transporter activity - - - - - Enables the transfer of organic hydroxy compound from one side of a membrane to the other. - GOC:TermGenie - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. - pr - 2012-11-20T09:45:15Z - biological_process - GO:1901652 - response to peptide - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. - GOC:TermGenie - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - - A response that results in a state of tolerance to ketone. - pr - 2012-11-20T10:55:47Z - GO:1990369 - process resulting in tolerance to ketone - biological_process - GO:1901654 - response to ketone - - - - - A response that results in a state of tolerance to ketone. - GOC:mengo_curators - PMID:23356676 - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of a sulfur compound from one side of a membrane to the other. - pr - 2012-11-26T20:45:29Z - sulfur molecular entity transmembrane transporter activity - molecular_function - GO:1901682 - sulfur compound transmembrane transporter activity - - - - - Enables the transfer of a sulfur compound from one side of a membrane to the other. - GOC:TermGenie - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process. - pr - 2012-12-12T10:28:35Z - biological_process - GO:1901692 - regulation of compound eye retinal cell apoptotic process - - - - - Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process. - GOC:TermGenie - GOC:mtg_apoptosis - PMID:12021768 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process. - pr - 2012-12-12T10:28:40Z - down regulation of compound eye retinal cell apoptotic process - down-regulation of compound eye retinal cell apoptotic process - downregulation of compound eye retinal cell apoptotic process - inhibition of compound eye retinal cell apoptotic process - biological_process - GO:1901693 - negative regulation of compound eye retinal cell apoptotic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process. - GOC:TermGenie - GOC:mtg_apoptosis - PMID:12021768 - - - - - down regulation of compound eye retinal cell apoptotic process - GOC:TermGenie - - - - - down-regulation of compound eye retinal cell apoptotic process - GOC:TermGenie - - - - - downregulation of compound eye retinal cell apoptotic process - GOC:TermGenie - - - - - inhibition of compound eye retinal cell apoptotic process - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process. - pr - 2012-12-12T10:28:45Z - GO:0046675 - up regulation of compound eye retinal cell apoptotic process - up-regulation of compound eye retinal cell apoptotic process - upregulation of compound eye retinal cell apoptotic process - activation of compound eye retinal cell apoptotic process - biological_process - induction of compound eye retinal cell programmed cell death - GO:1901694 - positive regulation of compound eye retinal cell apoptotic process - - - - - Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process. - GOC:TermGenie - GOC:mtg_apoptosis - PMID:12021768 - - - - - up regulation of compound eye retinal cell apoptotic process - GOC:TermGenie - - - - - up-regulation of compound eye retinal cell apoptotic process - GOC:TermGenie - - - - - upregulation of compound eye retinal cell apoptotic process - GOC:TermGenie - - - - - activation of compound eye retinal cell apoptotic process - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. - pr - 2012-12-13T15:06:08Z - response to nitrogen molecular entity - biological_process - GO:1901698 - response to nitrogen compound - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. - GOC:TermGenie - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. - pr - 2012-12-13T15:11:37Z - response to oxygen molecular entity - biological_process - GO:1901700 - response to oxygen-containing compound - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. - GOC:TermGenie - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of salt from one side of a membrane to the other. - pr - 2012-12-13T15:14:47Z - molecular_function - GO:1901702 - salt transmembrane transporter activity - - - - - Enables the transfer of salt from one side of a membrane to the other. - GOC:TermGenie - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state. - hjd - 2012-12-14T16:04:16Z - biological_process - GO:1901706 - mesenchymal cell differentiation involved in bone development - - - - - The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state. - GOC:TermGenie - GOC:hjd - PMID:21571217 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of muscle tissue development. - yaf - 2013-02-01T10:30:47Z - biological_process - GO:1901861 - regulation of muscle tissue development - - - - - Any process that modulates the frequency, rate or extent of muscle tissue development. - GOC:TermGenie - GOC:yaf - PMID:23150719 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. - yaf - 2013-02-01T10:30:52Z - down regulation of muscle tissue development - down-regulation of muscle tissue development - downregulation of muscle tissue development - inhibition of muscle tissue development - biological_process - GO:1901862 - negative regulation of muscle tissue development - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. - GOC:TermGenie - GOC:yaf - PMID:23150719 - - - - - down regulation of muscle tissue development - GOC:TermGenie - - - - - down-regulation of muscle tissue development - GOC:TermGenie - - - - - downregulation of muscle tissue development - GOC:TermGenie - - - - - inhibition of muscle tissue development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of muscle tissue development. - yaf - 2013-02-01T10:30:57Z - up regulation of muscle tissue development - up-regulation of muscle tissue development - upregulation of muscle tissue development - activation of muscle tissue development - biological_process - GO:1901863 - positive regulation of muscle tissue development - - - - - Any process that activates or increases the frequency, rate or extent of muscle tissue development. - GOC:TermGenie - GOC:yaf - PMID:23150719 - - - - - up regulation of muscle tissue development - GOC:TermGenie - - - - - up-regulation of muscle tissue development - GOC:TermGenie - - - - - upregulation of muscle tissue development - GOC:TermGenie - - - - - activation of muscle tissue development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of protein depolymerization. - rl - 2013-02-06T13:57:23Z - regulation of protein polymer breakdown - regulation of protein polymer catabolic process - regulation of protein polymer catabolism - regulation of protein polymer degradation - biological_process - GO:1901879 - regulation of protein depolymerization - - - - - Any process that modulates the frequency, rate or extent of protein depolymerization. - GOC:BHF - GOC:TermGenie - GOC:rl - PMID:12032137 - - - - - regulation of protein polymer breakdown - GOC:TermGenie - - - - - regulation of protein polymer catabolic process - GOC:TermGenie - - - - - regulation of protein polymer catabolism - GOC:TermGenie - - - - - regulation of protein polymer degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization. - rl - 2013-02-06T13:57:28Z - down regulation of protein depolymerization - down regulation of protein polymer breakdown - down regulation of protein polymer catabolic process - down regulation of protein polymer catabolism - down regulation of protein polymer degradation - down-regulation of protein depolymerization - down-regulation of protein polymer breakdown - down-regulation of protein polymer catabolic process - down-regulation of protein polymer catabolism - down-regulation of protein polymer degradation - downregulation of protein depolymerization - downregulation of protein polymer breakdown - downregulation of protein polymer catabolic process - downregulation of protein polymer catabolism - downregulation of protein polymer degradation - inhibition of protein polymer breakdown - inhibition of protein polymer catabolic process - inhibition of protein polymer catabolism - inhibition of protein polymer degradation - negative regulation of protein polymer breakdown - negative regulation of protein polymer catabolic process - negative regulation of protein polymer catabolism - negative regulation of protein polymer degradation - inhibition of protein depolymerization - biological_process - GO:1901880 - negative regulation of protein depolymerization - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization. - GOC:BHF - GOC:TermGenie - GOC:rl - PMID:12032137 - - - - - down regulation of protein depolymerization - GOC:TermGenie - - - - - down regulation of protein polymer breakdown - GOC:TermGenie - - - - - down regulation of protein polymer catabolic process - GOC:TermGenie - - - - - down regulation of protein polymer catabolism - GOC:TermGenie - - - - - down regulation of protein polymer degradation - GOC:TermGenie - - - - - down-regulation of protein depolymerization - GOC:TermGenie - - - - - down-regulation of protein polymer breakdown - GOC:TermGenie - - - - - down-regulation of protein polymer catabolic process - GOC:TermGenie - - - - - down-regulation of protein polymer catabolism - GOC:TermGenie - - - - - down-regulation of protein polymer degradation - GOC:TermGenie - - - - - downregulation of protein depolymerization - GOC:TermGenie - - - - - downregulation of protein polymer breakdown - GOC:TermGenie - - - - - downregulation of protein polymer catabolic process - GOC:TermGenie - - - - - downregulation of protein polymer catabolism - GOC:TermGenie - - - - - downregulation of protein polymer degradation - GOC:TermGenie - - - - - inhibition of protein polymer breakdown - GOC:TermGenie - - - - - inhibition of protein polymer catabolic process - GOC:TermGenie - - - - - inhibition of protein polymer catabolism - GOC:TermGenie - - - - - inhibition of protein polymer degradation - GOC:TermGenie - - - - - negative regulation of protein polymer breakdown - GOC:TermGenie - - - - - negative regulation of protein polymer catabolic process - GOC:TermGenie - - - - - negative regulation of protein polymer catabolism - GOC:TermGenie - - - - - negative regulation of protein polymer degradation - GOC:TermGenie - - - - - inhibition of protein depolymerization - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of protein depolymerization. - rl - 2013-02-06T13:57:32Z - activation of protein polymer breakdown - activation of protein polymer catabolic process - activation of protein polymer catabolism - activation of protein polymer degradation - positive regulation of protein polymer breakdown - positive regulation of protein polymer catabolic process - positive regulation of protein polymer catabolism - positive regulation of protein polymer degradation - up regulation of protein depolymerization - up regulation of protein polymer breakdown - up regulation of protein polymer catabolic process - up regulation of protein polymer catabolism - up regulation of protein polymer degradation - up-regulation of protein depolymerization - up-regulation of protein polymer breakdown - up-regulation of protein polymer catabolic process - up-regulation of protein polymer catabolism - up-regulation of protein polymer degradation - upregulation of protein depolymerization - upregulation of protein polymer breakdown - upregulation of protein polymer catabolic process - upregulation of protein polymer catabolism - upregulation of protein polymer degradation - activation of protein depolymerization - biological_process - GO:1901881 - positive regulation of protein depolymerization - - - - - Any process that activates or increases the frequency, rate or extent of protein depolymerization. - GOC:BHF - GOC:TermGenie - GOC:rl - PMID:12032137 - - - - - activation of protein polymer breakdown - GOC:TermGenie - - - - - activation of protein polymer catabolic process - GOC:TermGenie - - - - - activation of protein polymer catabolism - GOC:TermGenie - - - - - activation of protein polymer degradation - GOC:TermGenie - - - - - positive regulation of protein polymer breakdown - GOC:TermGenie - - - - - positive regulation of protein polymer catabolic process - GOC:TermGenie - - - - - positive regulation of protein polymer catabolism - GOC:TermGenie - - - - - positive regulation of protein polymer degradation - GOC:TermGenie - - - - - up regulation of protein depolymerization - GOC:TermGenie - - - - - up regulation of protein polymer breakdown - GOC:TermGenie - - - - - up regulation of protein polymer catabolic process - GOC:TermGenie - - - - - up regulation of protein polymer catabolism - GOC:TermGenie - - - - - up regulation of protein polymer degradation - GOC:TermGenie - - - - - up-regulation of protein depolymerization - GOC:TermGenie - - - - - up-regulation of protein polymer breakdown - GOC:TermGenie - - - - - up-regulation of protein polymer catabolic process - GOC:TermGenie - - - - - up-regulation of protein polymer catabolism - GOC:TermGenie - - - - - up-regulation of protein polymer degradation - GOC:TermGenie - - - - - upregulation of protein depolymerization - GOC:TermGenie - - - - - upregulation of protein polymer breakdown - GOC:TermGenie - - - - - upregulation of protein polymer catabolic process - GOC:TermGenie - - - - - upregulation of protein polymer catabolism - GOC:TermGenie - - - - - upregulation of protein polymer degradation - GOC:TermGenie - - - - - activation of protein depolymerization - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cell junction assembly. - tb - 2013-02-06T19:40:32Z - biological_process - GO:1901888 - regulation of cell junction assembly - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of cell junction assembly. - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. - tb - 2013-02-06T19:40:41Z - down regulation of cell junction assembly - down-regulation of cell junction assembly - downregulation of cell junction assembly - inhibition of cell junction assembly - biological_process - GO:1901889 - negative regulation of cell junction assembly - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. - GOC:TermGenie - - - - - down regulation of cell junction assembly - GOC:TermGenie - - - - - down-regulation of cell junction assembly - GOC:TermGenie - - - - - downregulation of cell junction assembly - GOC:TermGenie - - - - - inhibition of cell junction assembly - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cell junction assembly. - tb - 2013-02-06T19:40:46Z - up regulation of cell junction assembly - up-regulation of cell junction assembly - upregulation of cell junction assembly - activation of cell junction assembly - biological_process - GO:1901890 - positive regulation of cell junction assembly - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of cell junction assembly. - GOC:TermGenie - - - - - up regulation of cell junction assembly - GOC:TermGenie - - - - - up-regulation of cell junction assembly - GOC:TermGenie - - - - - upregulation of cell junction assembly - GOC:TermGenie - - - - - activation of cell junction assembly - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. - dph - 2013-02-20T20:30:26Z - biological_process - GO:1901963 - regulation of cell proliferation involved in outflow tract morphogenesis - - - - - Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. - GOC:TermGenie - GOC:dph - GOC:mtg_heart - PMID:21419760 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. - dph - 2013-02-20T20:30:31Z - up regulation of cell proliferation involved in outflow tract morphogenesis - up-regulation of cell proliferation involved in outflow tract morphogenesis - upregulation of cell proliferation involved in outflow tract morphogenesis - activation of cell proliferation involved in outflow tract morphogenesis - biological_process - GO:1901964 - positive regulation of cell proliferation involved in outflow tract morphogenesis - - - - - Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. - GOC:TermGenie - GOC:dph - GOC:mtg_heart - PMID:21419760 - - - - - up regulation of cell proliferation involved in outflow tract morphogenesis - GOC:TermGenie - - - - - up-regulation of cell proliferation involved in outflow tract morphogenesis - GOC:TermGenie - - - - - upregulation of cell proliferation involved in outflow tract morphogenesis - GOC:TermGenie - - - - - activation of cell proliferation involved in outflow tract morphogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cilium assembly. - dph - 2013-03-26T18:10:51Z - regulation of ciliogenesis - biological_process - regulation of cilium biogenesis - GO:1902017 - regulation of cilium assembly - - - - - Any process that modulates the frequency, rate or extent of cilium assembly. - GOC:TermGenie - GOC:cilia - GOC:dph - PMID:17719545 - - - - - regulation of ciliogenesis - GOC:TermGenie - - - - - regulation of cilium biogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly. - dph - 2013-03-26T18:10:56Z - down regulation of ciliogenesis - down regulation of cilium assembly - down-regulation of ciliogenesis - down-regulation of cilium assembly - downregulation of ciliogenesis - downregulation of cilium assembly - inhibition of ciliogenesis - negative regulation of ciliogenesis - inhibition of cilium assembly - biological_process - down regulation of cilium biogenesis - down-regulation of cilium biogenesis - downregulation of cilium biogenesis - inhibition of cilium biogenesis - negative regulation of cilium biogenesis - GO:1902018 - negative regulation of cilium assembly - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly. - GOC:TermGenie - GOC:cilia - GOC:dph - PMID:17719545 - - - - - down regulation of ciliogenesis - GOC:TermGenie - - - - - down regulation of cilium assembly - GOC:TermGenie - - - - - down-regulation of ciliogenesis - GOC:TermGenie - - - - - down-regulation of cilium assembly - GOC:TermGenie - - - - - downregulation of ciliogenesis - GOC:TermGenie - - - - - downregulation of cilium assembly - GOC:TermGenie - - - - - inhibition of ciliogenesis - GOC:TermGenie - - - - - negative regulation of ciliogenesis - GOC:TermGenie - - - - - inhibition of cilium assembly - GOC:TermGenie - - - - - down regulation of cilium biogenesis - GOC:TermGenie - - - - - down-regulation of cilium biogenesis - GOC:TermGenie - - - - - downregulation of cilium biogenesis - GOC:TermGenie - - - - - inhibition of cilium biogenesis - GOC:TermGenie - - - - - negative regulation of cilium biogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation. - ss - 2013-04-02T05:13:19Z - regulation of hemopoietic stem cell proliferation - biological_process - GO:1902033 - regulation of hematopoietic stem cell proliferation - - - - - Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation. - GOC:TermGenie - PMID:23403623 - - - - - regulation of hemopoietic stem cell proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation. - ss - 2013-04-02T05:13:24Z - down regulation of hematopoietic stem cell proliferation - down regulation of hemopoietic stem cell proliferation - down-regulation of hematopoietic stem cell proliferation - down-regulation of hemopoietic stem cell proliferation - downregulation of hematopoietic stem cell proliferation - downregulation of hemopoietic stem cell proliferation - negative regulation of hemopoietic stem cell proliferation - inhibition of hematopoietic stem cell proliferation - inhibition of hemopoietic stem cell proliferation - biological_process - GO:1902034 - negative regulation of hematopoietic stem cell proliferation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation. - GOC:TermGenie - PMID:23403623 - - - - - down regulation of hematopoietic stem cell proliferation - GOC:TermGenie - - - - - down regulation of hemopoietic stem cell proliferation - GOC:TermGenie - - - - - down-regulation of hematopoietic stem cell proliferation - GOC:TermGenie - - - - - down-regulation of hemopoietic stem cell proliferation - GOC:TermGenie - - - - - downregulation of hematopoietic stem cell proliferation - GOC:TermGenie - - - - - downregulation of hemopoietic stem cell proliferation - GOC:TermGenie - - - - - negative regulation of hemopoietic stem cell proliferation - GOC:TermGenie - - - - - inhibition of hematopoietic stem cell proliferation - GOC:TermGenie - - - - - inhibition of hemopoietic stem cell proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation. - ss - 2013-04-02T05:13:31Z - positive regulation of hemopoietic stem cell proliferation - up regulation of hematopoietic stem cell proliferation - up regulation of hemopoietic stem cell proliferation - up-regulation of hematopoietic stem cell proliferation - up-regulation of hemopoietic stem cell proliferation - upregulation of hematopoietic stem cell proliferation - upregulation of hemopoietic stem cell proliferation - activation of hematopoietic stem cell proliferation - activation of hemopoietic stem cell proliferation - biological_process - GO:1902035 - positive regulation of hematopoietic stem cell proliferation - - - - - Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation. - GOC:TermGenie - PMID:23403623 - - - - - positive regulation of hemopoietic stem cell proliferation - GOC:TermGenie - - - - - up regulation of hematopoietic stem cell proliferation - GOC:TermGenie - - - - - up regulation of hemopoietic stem cell proliferation - GOC:TermGenie - - - - - up-regulation of hematopoietic stem cell proliferation - GOC:TermGenie - - - - - up-regulation of hemopoietic stem cell proliferation - GOC:TermGenie - - - - - upregulation of hematopoietic stem cell proliferation - GOC:TermGenie - - - - - upregulation of hemopoietic stem cell proliferation - GOC:TermGenie - - - - - activation of hematopoietic stem cell proliferation - GOC:TermGenie - - - - - activation of hemopoietic stem cell proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation. - ss - 2013-04-02T05:19:09Z - regulation of haematopoietic stem cell differentiation - regulation of haemopoietic stem cell differentiation - regulation of hemopoietic stem cell differentiation - biological_process - GO:1902036 - regulation of hematopoietic stem cell differentiation - - - - - Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation. - GOC:TermGenie - PMID:23403623 - - - - - regulation of haematopoietic stem cell differentiation - GOC:TermGenie - - - - - regulation of haemopoietic stem cell differentiation - GOC:TermGenie - - - - - regulation of hemopoietic stem cell differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation. - ss - 2013-04-02T05:19:14Z - down regulation of haematopoietic stem cell differentiation - down regulation of haemopoietic stem cell differentiation - down regulation of hematopoietic stem cell differentiation - down regulation of hemopoietic stem cell differentiation - down-regulation of haematopoietic stem cell differentiation - down-regulation of haemopoietic stem cell differentiation - down-regulation of hematopoietic stem cell differentiation - down-regulation of hemopoietic stem cell differentiation - downregulation of haematopoietic stem cell differentiation - downregulation of haemopoietic stem cell differentiation - downregulation of hematopoietic stem cell differentiation - downregulation of hemopoietic stem cell differentiation - negative regulation of haematopoietic stem cell differentiation - negative regulation of haemopoietic stem cell differentiation - negative regulation of hemopoietic stem cell differentiation - inhibition of haematopoietic stem cell differentiation - inhibition of haemopoietic stem cell differentiation - inhibition of hematopoietic stem cell differentiation - inhibition of hemopoietic stem cell differentiation - biological_process - GO:1902037 - negative regulation of hematopoietic stem cell differentiation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation. - GOC:TermGenie - PMID:23403623 - - - - - down regulation of haematopoietic stem cell differentiation - GOC:TermGenie - - - - - down regulation of haemopoietic stem cell differentiation - GOC:TermGenie - - - - - down regulation of hematopoietic stem cell differentiation - GOC:TermGenie - - - - - down regulation of hemopoietic stem cell differentiation - GOC:TermGenie - - - - - down-regulation of haematopoietic stem cell differentiation - GOC:TermGenie - - - - - down-regulation of haemopoietic stem cell differentiation - GOC:TermGenie - - - - - down-regulation of hematopoietic stem cell differentiation - GOC:TermGenie - - - - - down-regulation of hemopoietic stem cell differentiation - GOC:TermGenie - - - - - downregulation of haematopoietic stem cell differentiation - GOC:TermGenie - - - - - downregulation of haemopoietic stem cell differentiation - GOC:TermGenie - - - - - downregulation of hematopoietic stem cell differentiation - GOC:TermGenie - - - - - downregulation of hemopoietic stem cell differentiation - GOC:TermGenie - - - - - negative regulation of haematopoietic stem cell differentiation - GOC:TermGenie - - - - - negative regulation of haemopoietic stem cell differentiation - GOC:TermGenie - - - - - negative regulation of hemopoietic stem cell differentiation - GOC:TermGenie - - - - - inhibition of haematopoietic stem cell differentiation - GOC:TermGenie - - - - - inhibition of haemopoietic stem cell differentiation - GOC:TermGenie - - - - - inhibition of hematopoietic stem cell differentiation - GOC:TermGenie - - - - - inhibition of hemopoietic stem cell differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation. - ss - 2013-04-02T05:19:19Z - positive regulation of haematopoietic stem cell differentiation - positive regulation of haemopoietic stem cell differentiation - positive regulation of hemopoietic stem cell differentiation - up regulation of haematopoietic stem cell differentiation - up regulation of haemopoietic stem cell differentiation - up regulation of hematopoietic stem cell differentiation - up regulation of hemopoietic stem cell differentiation - up-regulation of haematopoietic stem cell differentiation - up-regulation of haemopoietic stem cell differentiation - up-regulation of hematopoietic stem cell differentiation - up-regulation of hemopoietic stem cell differentiation - upregulation of haematopoietic stem cell differentiation - upregulation of haemopoietic stem cell differentiation - upregulation of hematopoietic stem cell differentiation - upregulation of hemopoietic stem cell differentiation - activation of haematopoietic stem cell differentiation - activation of haemopoietic stem cell differentiation - activation of hematopoietic stem cell differentiation - activation of hemopoietic stem cell differentiation - biological_process - GO:1902038 - positive regulation of hematopoietic stem cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation. - GOC:TermGenie - PMID:23403623 - - - - - positive regulation of haematopoietic stem cell differentiation - GOC:TermGenie - - - - - positive regulation of haemopoietic stem cell differentiation - GOC:TermGenie - - - - - positive regulation of hemopoietic stem cell differentiation - GOC:TermGenie - - - - - up regulation of haematopoietic stem cell differentiation - GOC:TermGenie - - - - - up regulation of haemopoietic stem cell differentiation - GOC:TermGenie - - - - - up regulation of hematopoietic stem cell differentiation - GOC:TermGenie - - - - - up regulation of hemopoietic stem cell differentiation - GOC:TermGenie - - - - - up-regulation of haematopoietic stem cell differentiation - GOC:TermGenie - - - - - up-regulation of haemopoietic stem cell differentiation - GOC:TermGenie - - - - - up-regulation of hematopoietic stem cell differentiation - GOC:TermGenie - - - - - up-regulation of hemopoietic stem cell differentiation - GOC:TermGenie - - - - - upregulation of haematopoietic stem cell differentiation - GOC:TermGenie - - - - - upregulation of haemopoietic stem cell differentiation - GOC:TermGenie - - - - - upregulation of hematopoietic stem cell differentiation - GOC:TermGenie - - - - - upregulation of hemopoietic stem cell differentiation - GOC:TermGenie - - - - - activation of haematopoietic stem cell differentiation - GOC:TermGenie - - - - - activation of haemopoietic stem cell differentiation - GOC:TermGenie - - - - - activation of hematopoietic stem cell differentiation - GOC:TermGenie - - - - - activation of hemopoietic stem cell differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus. - mls - 2013-04-22T15:41:57Z - response to salinity - biological_process - GO:1902074 - response to salt - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus. - GOC:TermGenie - GOC:mls - PMID:16666921 - - - - - response to salinity - GOC:mls - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of leukocyte differentiation. - pr - 2013-05-02T17:32:42Z - regulation of immune cell differentiation - regulation of leucocyte differentiation - biological_process - GO:1902105 - regulation of leukocyte differentiation - - - - - Any process that modulates the frequency, rate or extent of leukocyte differentiation. - GOC:TermGenie - GOC:add - - - - - regulation of immune cell differentiation - GOC:TermGenie - - - - - regulation of leucocyte differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. - pr - 2013-05-02T17:32:47Z - down regulation of immune cell differentiation - down regulation of leucocyte differentiation - down regulation of leukocyte differentiation - down-regulation of immune cell differentiation - down-regulation of leucocyte differentiation - down-regulation of leukocyte differentiation - downregulation of immune cell differentiation - downregulation of leucocyte differentiation - downregulation of leukocyte differentiation - negative regulation of immune cell differentiation - negative regulation of leucocyte differentiation - inhibition of immune cell differentiation - inhibition of leucocyte differentiation - inhibition of leukocyte differentiation - biological_process - GO:1902106 - negative regulation of leukocyte differentiation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. - GOC:TermGenie - GOC:add - - - - - down regulation of immune cell differentiation - GOC:TermGenie - - - - - down regulation of leucocyte differentiation - GOC:TermGenie - - - - - down regulation of leukocyte differentiation - GOC:TermGenie - - - - - down-regulation of immune cell differentiation - GOC:TermGenie - - - - - down-regulation of leucocyte differentiation - GOC:TermGenie - - - - - down-regulation of leukocyte differentiation - GOC:TermGenie - - - - - downregulation of immune cell differentiation - GOC:TermGenie - - - - - downregulation of leucocyte differentiation - GOC:TermGenie - - - - - downregulation of leukocyte differentiation - GOC:TermGenie - - - - - negative regulation of immune cell differentiation - GOC:TermGenie - - - - - negative regulation of leucocyte differentiation - GOC:TermGenie - - - - - inhibition of immune cell differentiation - GOC:TermGenie - - - - - inhibition of leucocyte differentiation - GOC:TermGenie - - - - - inhibition of leukocyte differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. - pr - 2013-05-02T17:32:52Z - positive regulation of immune cell differentiation - positive regulation of leucocyte differentiation - up regulation of immune cell differentiation - up regulation of leucocyte differentiation - up regulation of leukocyte differentiation - up-regulation of immune cell differentiation - up-regulation of leucocyte differentiation - up-regulation of leukocyte differentiation - upregulation of immune cell differentiation - upregulation of leucocyte differentiation - upregulation of leukocyte differentiation - activation of immune cell differentiation - activation of leucocyte differentiation - activation of leukocyte differentiation - biological_process - GO:1902107 - positive regulation of leukocyte differentiation - - - - - Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. - GOC:TermGenie - GOC:add - - - - - positive regulation of immune cell differentiation - GOC:TermGenie - - - - - positive regulation of leucocyte differentiation - GOC:TermGenie - - - - - up regulation of immune cell differentiation - GOC:TermGenie - - - - - up regulation of leucocyte differentiation - GOC:TermGenie - - - - - up regulation of leukocyte differentiation - GOC:TermGenie - - - - - up-regulation of immune cell differentiation - GOC:TermGenie - - - - - up-regulation of leucocyte differentiation - GOC:TermGenie - - - - - up-regulation of leukocyte differentiation - GOC:TermGenie - - - - - upregulation of immune cell differentiation - GOC:TermGenie - - - - - upregulation of leucocyte differentiation - GOC:TermGenie - - - - - upregulation of leukocyte differentiation - GOC:TermGenie - - - - - activation of immune cell differentiation - GOC:TermGenie - - - - - activation of leucocyte differentiation - GOC:TermGenie - - - - - activation of leukocyte differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of organelle assembly. - pr - 2013-05-14T09:43:21Z - biological_process - GO:1902115 - regulation of organelle assembly - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of organelle assembly. - GOC:TermGenie - GOC:pr - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly. - pr - 2013-05-14T09:43:31Z - down regulation of organelle assembly - down-regulation of organelle assembly - downregulation of organelle assembly - inhibition of organelle assembly - biological_process - GO:1902116 - negative regulation of organelle assembly - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly. - GOC:TermGenie - GOC:pr - - - - - down regulation of organelle assembly - GOC:TermGenie - - - - - down-regulation of organelle assembly - GOC:TermGenie - - - - - downregulation of organelle assembly - GOC:TermGenie - - - - - inhibition of organelle assembly - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of organelle assembly. - pr - 2013-05-14T09:43:36Z - up regulation of organelle assembly - up-regulation of organelle assembly - upregulation of organelle assembly - activation of organelle assembly - biological_process - GO:1902117 - positive regulation of organelle assembly - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of organelle assembly. - GOC:TermGenie - GOC:pr - - - - - up regulation of organelle assembly - GOC:TermGenie - - - - - up-regulation of organelle assembly - GOC:TermGenie - - - - - upregulation of organelle assembly - GOC:TermGenie - - - - - activation of organelle assembly - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in an erythrocyte. - - rl - 2013-06-13T10:02:29Z - RBC apoptotic process - red blood cell apoptotic process - RBC apoptosis - erythrocyte apoptosis - red blood cell apoptosis - biological_process - GO:1902217 - erythrocyte apoptotic process - - - - - Any apoptotic process in an erythrocyte. - GOC:BHF - GOC:TermGenie - GOC:mtg_apoptosis - GOC:rl - PMID:14569084 - - - - - RBC apoptotic process - GOC:TermGenie - - - - - red blood cell apoptotic process - GOC:TermGenie - - - - - RBC apoptosis - GOC:TermGenie - - - - - erythrocyte apoptosis - GOC:TermGenie - - - - - red blood cell apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process. - rl - 2013-06-20T19:30:53Z - regulation of RBC apoptotic process - regulation of red blood cell apoptotic process - regulation of RBC apoptosis - regulation of erythrocyte apoptosis - regulation of red blood cell apoptosis - biological_process - GO:1902250 - regulation of erythrocyte apoptotic process - - - - - Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process. - GOC:BHF - GOC:TermGenie - GOC:mtg_apoptosis - GOC:rl - PMID:14569084 - - - - - regulation of RBC apoptotic process - GOC:TermGenie - - - - - regulation of red blood cell apoptotic process - GOC:TermGenie - - - - - regulation of RBC apoptosis - GOC:TermGenie - - - - - regulation of erythrocyte apoptosis - GOC:TermGenie - - - - - regulation of red blood cell apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process. - - rl - 2013-06-20T19:30:59Z - down regulation of RBC apoptotic process - down regulation of erythrocyte apoptotic process - down regulation of red blood cell apoptotic process - down-regulation of RBC apoptotic process - down-regulation of erythrocyte apoptotic process - down-regulation of red blood cell apoptotic process - downregulation of RBC apoptotic process - downregulation of erythrocyte apoptotic process - downregulation of red blood cell apoptotic process - negative regulation of RBC apoptotic process - negative regulation of red blood cell apoptotic process - down regulation of RBC apoptosis - down regulation of erythrocyte apoptosis - down regulation of red blood cell apoptosis - down-regulation of RBC apoptosis - down-regulation of erythrocyte apoptosis - down-regulation of red blood cell apoptosis - downregulation of RBC apoptosis - downregulation of erythrocyte apoptosis - downregulation of red blood cell apoptosis - inhibition of RBC apoptosis - inhibition of RBC apoptotic process - inhibition of erythrocyte apoptosis - inhibition of erythrocyte apoptotic process - inhibition of red blood cell apoptosis - inhibition of red blood cell apoptotic process - negative regulation of RBC apoptosis - negative regulation of erythrocyte apoptosis - negative regulation of red blood cell apoptosis - biological_process - GO:1902251 - negative regulation of erythrocyte apoptotic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process. - GOC:BHF - GOC:TermGenie - GOC:mtg_apoptosis - GOC:rl - PMID:14569084 - - - - - down regulation of RBC apoptotic process - GOC:TermGenie - - - - - down regulation of erythrocyte apoptotic process - GOC:TermGenie - - - - - down regulation of red blood cell apoptotic process - GOC:TermGenie - - - - - down-regulation of RBC apoptotic process - GOC:TermGenie - - - - - down-regulation of erythrocyte apoptotic process - GOC:TermGenie - - - - - down-regulation of red blood cell apoptotic process - GOC:TermGenie - - - - - downregulation of RBC apoptotic process - GOC:TermGenie - - - - - downregulation of erythrocyte apoptotic process - GOC:TermGenie - - - - - downregulation of red blood cell apoptotic process - GOC:TermGenie - - - - - negative regulation of RBC apoptotic process - GOC:TermGenie - - - - - negative regulation of red blood cell apoptotic process - GOC:TermGenie - - - - - down regulation of RBC apoptosis - GOC:TermGenie - - - - - down regulation of erythrocyte apoptosis - GOC:TermGenie - - - - - down regulation of red blood cell apoptosis - GOC:TermGenie - - - - - down-regulation of RBC apoptosis - GOC:TermGenie - - - - - down-regulation of erythrocyte apoptosis - GOC:TermGenie - - - - - down-regulation of red blood cell apoptosis - GOC:TermGenie - - - - - downregulation of RBC apoptosis - GOC:TermGenie - - - - - downregulation of erythrocyte apoptosis - GOC:TermGenie - - - - - downregulation of red blood cell apoptosis - GOC:TermGenie - - - - - inhibition of RBC apoptosis - GOC:TermGenie - - - - - inhibition of RBC apoptotic process - GOC:TermGenie - - - - - inhibition of erythrocyte apoptosis - GOC:TermGenie - - - - - inhibition of erythrocyte apoptotic process - GOC:TermGenie - - - - - inhibition of red blood cell apoptosis - GOC:TermGenie - - - - - inhibition of red blood cell apoptotic process - GOC:TermGenie - - - - - negative regulation of RBC apoptosis - GOC:TermGenie - - - - - negative regulation of erythrocyte apoptosis - GOC:TermGenie - - - - - negative regulation of red blood cell apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process. - - rl - 2013-06-20T19:31:04Z - positive regulation of RBC apoptotic process - positive regulation of red blood cell apoptotic process - up regulation of RBC apoptotic process - up regulation of erythrocyte apoptotic process - up regulation of red blood cell apoptotic process - up-regulation of RBC apoptotic process - up-regulation of erythrocyte apoptotic process - up-regulation of red blood cell apoptotic process - upregulation of RBC apoptotic process - upregulation of erythrocyte apoptotic process - upregulation of red blood cell apoptotic process - activation of RBC apoptosis - activation of RBC apoptotic process - activation of erythrocyte apoptosis - activation of erythrocyte apoptotic process - activation of red blood cell apoptosis - activation of red blood cell apoptotic process - positive regulation of RBC apoptosis - positive regulation of erythrocyte apoptosis - positive regulation of red blood cell apoptosis - up regulation of RBC apoptosis - up regulation of erythrocyte apoptosis - up regulation of red blood cell apoptosis - up-regulation of RBC apoptosis - up-regulation of erythrocyte apoptosis - up-regulation of red blood cell apoptosis - upregulation of RBC apoptosis - upregulation of erythrocyte apoptosis - upregulation of red blood cell apoptosis - biological_process - GO:1902252 - positive regulation of erythrocyte apoptotic process - - - - - Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process. - GOC:BHF - GOC:TermGenie - GOC:mtg_apoptosis - GOC:rl - PMID:14569084 - - - - - positive regulation of RBC apoptotic process - GOC:TermGenie - - - - - positive regulation of red blood cell apoptotic process - GOC:TermGenie - - - - - up regulation of RBC apoptotic process - GOC:TermGenie - - - - - up regulation of erythrocyte apoptotic process - GOC:TermGenie - - - - - up regulation of red blood cell apoptotic process - GOC:TermGenie - - - - - up-regulation of RBC apoptotic process - GOC:TermGenie - - - - - up-regulation of erythrocyte apoptotic process - GOC:TermGenie - - - - - up-regulation of red blood cell apoptotic process - GOC:TermGenie - - - - - upregulation of RBC apoptotic process - GOC:TermGenie - - - - - upregulation of erythrocyte apoptotic process - GOC:TermGenie - - - - - upregulation of red blood cell apoptotic process - GOC:TermGenie - - - - - activation of RBC apoptosis - GOC:TermGenie - - - - - activation of RBC apoptotic process - GOC:TermGenie - - - - - activation of erythrocyte apoptosis - GOC:TermGenie - - - - - activation of erythrocyte apoptotic process - GOC:TermGenie - - - - - activation of red blood cell apoptosis - GOC:TermGenie - - - - - activation of red blood cell apoptotic process - GOC:TermGenie - - - - - positive regulation of RBC apoptosis - GOC:TermGenie - - - - - positive regulation of erythrocyte apoptosis - GOC:TermGenie - - - - - positive regulation of red blood cell apoptosis - GOC:TermGenie - - - - - up regulation of RBC apoptosis - GOC:TermGenie - - - - - up regulation of erythrocyte apoptosis - GOC:TermGenie - - - - - up regulation of red blood cell apoptosis - GOC:TermGenie - - - - - up-regulation of RBC apoptosis - GOC:TermGenie - - - - - up-regulation of erythrocyte apoptosis - GOC:TermGenie - - - - - up-regulation of red blood cell apoptosis - GOC:TermGenie - - - - - upregulation of RBC apoptosis - GOC:TermGenie - - - - - upregulation of erythrocyte apoptosis - GOC:TermGenie - - - - - upregulation of red blood cell apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. - dph - 2013-06-24T19:12:24Z - regulation of apoptosis involved in outflow tract morphogenesis - biological_process - GO:1902256 - regulation of apoptotic process involved in outflow tract morphogenesis - - - - - Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. - GOC:TermGenie - GOC:dph - GOC:mtg_apoptosis - PMID:16839542 - - - - - regulation of apoptosis involved in outflow tract morphogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. - dph - 2013-06-24T19:12:30Z - down regulation of apoptotic process involved in outflow tract morphogenesis - down-regulation of apoptotic process involved in outflow tract morphogenesis - downregulation of apoptotic process involved in outflow tract morphogenesis - down regulation of apoptosis involved in outflow tract morphogenesis - down-regulation of apoptosis involved in outflow tract morphogenesis - downregulation of apoptosis involved in outflow tract morphogenesis - inhibition of apoptosis involved in outflow tract morphogenesis - inhibition of apoptotic process involved in outflow tract morphogenesis - negative regulation of apoptosis involved in outflow tract morphogenesis - biological_process - GO:1902257 - negative regulation of apoptotic process involved in outflow tract morphogenesis - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. - GOC:TermGenie - GOC:dph - GOC:mtg_apoptosis - PMID:16839542 - - - - - down regulation of apoptotic process involved in outflow tract morphogenesis - GOC:TermGenie - - - - - down-regulation of apoptotic process involved in outflow tract morphogenesis - GOC:TermGenie - - - - - downregulation of apoptotic process involved in outflow tract morphogenesis - GOC:TermGenie - - - - - down regulation of apoptosis involved in outflow tract morphogenesis - GOC:TermGenie - - - - - down-regulation of apoptosis involved in outflow tract morphogenesis - GOC:TermGenie - - - - - downregulation of apoptosis involved in outflow tract morphogenesis - GOC:TermGenie - - - - - inhibition of apoptosis involved in outflow tract morphogenesis - GOC:TermGenie - - - - - inhibition of apoptotic process involved in outflow tract morphogenesis - GOC:TermGenie - - - - - negative regulation of apoptosis involved in outflow tract morphogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. - dph - 2013-06-24T19:12:42Z - up regulation of apoptotic process involved in outflow tract morphogenesis - up-regulation of apoptotic process involved in outflow tract morphogenesis - upregulation of apoptotic process involved in outflow tract morphogenesis - activation of apoptosis involved in outflow tract morphogenesis - activation of apoptotic process involved in outflow tract morphogenesis - positive regulation of apoptosis involved in outflow tract morphogenesis - up regulation of apoptosis involved in outflow tract morphogenesis - up-regulation of apoptosis involved in outflow tract morphogenesis - upregulation of apoptosis involved in outflow tract morphogenesis - biological_process - GO:1902258 - positive regulation of apoptotic process involved in outflow tract morphogenesis - - - - - Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. - GOC:TermGenie - GOC:dph - GOC:mtg_apoptosis - PMID:16839542 - - - - - up regulation of apoptotic process involved in outflow tract morphogenesis - GOC:TermGenie - - - - - up-regulation of apoptotic process involved in outflow tract morphogenesis - GOC:TermGenie - - - - - upregulation of apoptotic process involved in outflow tract morphogenesis - GOC:TermGenie - - - - - activation of apoptosis involved in outflow tract morphogenesis - GOC:TermGenie - - - - - activation of apoptotic process involved in outflow tract morphogenesis - GOC:TermGenie - - - - - positive regulation of apoptosis involved in outflow tract morphogenesis - GOC:TermGenie - - - - - up regulation of apoptosis involved in outflow tract morphogenesis - GOC:TermGenie - - - - - up-regulation of apoptosis involved in outflow tract morphogenesis - GOC:TermGenie - - - - - upregulation of apoptosis involved in outflow tract morphogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process that is involved in blood vessel morphogenesis. - dph - 2013-06-25T16:16:00Z - apoptotic cell death involved in patterning of blood vessels - apoptotic programmed cell death involved in patterning of blood vessels - programmed cell death by apoptosis involved in patterning of blood vessels - apoptosis involved in patterning of blood vessels - apoptotic program involved in patterning of blood vessels - type I programmed cell death involved in patterning of blood vessels - biological_process - signaling (initiator) caspase activity involved in patterning of blood vessels - GO:1902262 - apoptotic process involved in blood vessel morphogenesis - - - - - Any apoptotic process that is involved in blood vessel morphogenesis. - GOC:TermGenie - GOC:dph - GOC:mtg_apoptosis - PMID:16163358 - - - - - apoptotic cell death involved in patterning of blood vessels - GOC:TermGenie - - - - - apoptotic programmed cell death involved in patterning of blood vessels - GOC:TermGenie - - - - - programmed cell death by apoptosis involved in patterning of blood vessels - GOC:TermGenie - - - - - apoptosis involved in patterning of blood vessels - GOC:TermGenie - - - - - apoptotic program involved in patterning of blood vessels - GOC:TermGenie - - - - - type I programmed cell death involved in patterning of blood vessels - GOC:TermGenie - - - - - signaling (initiator) caspase activity involved in patterning of blood vessels - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of chromatin organization. - bf - 2013-07-01T13:21:52Z - GO:0001672 - GO:1903308 - regulation of chromatin organisation - regulation of establishment or maintenance of chromatin architecture - biological_process - regulation of chromatin assembly or disassembly - regulation of chromatin assembly/disassembly - regulation of chromatin modification - GO:1902275 - regulation of chromatin organization - - - - - Any process that modulates the frequency, rate or extent of chromatin organization. - GOC:TermGenie - GOC:bf - GOC:vw - GO_REF:0000058 - PMID:18314879 - - - - - regulation of chromatin organisation - GOC:TermGenie - - - - - regulation of establishment or maintenance of chromatin architecture - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport. - rl - 2013-07-18T13:33:53Z - regulation of sodium ion membrane transport - biological_process - GO:1902305 - regulation of sodium ion transmembrane transport - - - - - Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport. - GOC:BHF - GOC:TermGenie - GOC:mtg_cardiac_conduct_nov11 - GOC:rl - PMID:18591664 - - - - - regulation of sodium ion membrane transport - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport. - rl - 2013-07-18T13:34:01Z - down regulation of sodium ion membrane transport - down regulation of sodium ion transmembrane transport - down-regulation of sodium ion membrane transport - down-regulation of sodium ion transmembrane transport - downregulation of sodium ion membrane transport - downregulation of sodium ion transmembrane transport - negative regulation of sodium ion membrane transport - inhibition of sodium ion membrane transport - inhibition of sodium ion transmembrane transport - biological_process - GO:1902306 - negative regulation of sodium ion transmembrane transport - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport. - GOC:BHF - GOC:TermGenie - GOC:mtg_cardiac_conduct_nov11 - GOC:rl - PMID:18591664 - - - - - down regulation of sodium ion membrane transport - GOC:TermGenie - - - - - down regulation of sodium ion transmembrane transport - GOC:TermGenie - - - - - down-regulation of sodium ion membrane transport - GOC:TermGenie - - - - - down-regulation of sodium ion transmembrane transport - GOC:TermGenie - - - - - downregulation of sodium ion membrane transport - GOC:TermGenie - - - - - downregulation of sodium ion transmembrane transport - GOC:TermGenie - - - - - negative regulation of sodium ion membrane transport - GOC:TermGenie - - - - - inhibition of sodium ion membrane transport - GOC:TermGenie - - - - - inhibition of sodium ion transmembrane transport - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport. - rl - 2013-07-18T13:34:18Z - positive regulation of sodium ion membrane transport - up regulation of sodium ion membrane transport - up regulation of sodium ion transmembrane transport - up-regulation of sodium ion membrane transport - up-regulation of sodium ion transmembrane transport - upregulation of sodium ion membrane transport - upregulation of sodium ion transmembrane transport - activation of sodium ion membrane transport - activation of sodium ion transmembrane transport - biological_process - GO:1902307 - positive regulation of sodium ion transmembrane transport - - - - - Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport. - GOC:BHF - GOC:TermGenie - GOC:mtg_cardiac_conduct_nov11 - GOC:rl - PMID:18591664 - - - - - positive regulation of sodium ion membrane transport - GOC:TermGenie - - - - - up regulation of sodium ion membrane transport - GOC:TermGenie - - - - - up regulation of sodium ion transmembrane transport - GOC:TermGenie - - - - - up-regulation of sodium ion membrane transport - GOC:TermGenie - - - - - up-regulation of sodium ion transmembrane transport - GOC:TermGenie - - - - - upregulation of sodium ion membrane transport - GOC:TermGenie - - - - - upregulation of sodium ion transmembrane transport - GOC:TermGenie - - - - - activation of sodium ion membrane transport - GOC:TermGenie - - - - - activation of sodium ion transmembrane transport - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis. - sart - 2013-07-29T15:03:16Z - regulation of apoptosis involved in morphogenesis - biological_process - regulation of apoptosis involved in development - regulation of morphogenetic apoptosis - GO:1902337 - regulation of apoptotic process involved in morphogenesis - - - - - Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis. - GOC:TermGenie - GOC:sart - PMID:12202035 - - - - - regulation of apoptosis involved in morphogenesis - GOC:TermGenie - - - - - regulation of apoptosis involved in development - GOC:TermGenie - - - - - regulation of morphogenetic apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis. - sart - 2013-07-29T15:03:25Z - down regulation of apoptotic process involved in morphogenesis - down-regulation of apoptotic process involved in morphogenesis - downregulation of apoptotic process involved in morphogenesis - down regulation of apoptosis involved in morphogenesis - down-regulation of apoptosis involved in morphogenesis - downregulation of apoptosis involved in morphogenesis - inhibition of apoptosis involved in morphogenesis - inhibition of apoptotic process involved in morphogenesis - negative regulation of apoptosis involved in morphogenesis - biological_process - down regulation of apoptosis involved in development - down regulation of morphogenetic apoptosis - down-regulation of apoptosis involved in development - down-regulation of morphogenetic apoptosis - downregulation of apoptosis involved in development - downregulation of morphogenetic apoptosis - inhibition of apoptosis involved in development - inhibition of morphogenetic apoptosis - negative regulation of apoptosis involved in development - negative regulation of morphogenetic apoptosis - GO:1902338 - negative regulation of apoptotic process involved in morphogenesis - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis. - GOC:TermGenie - GOC:sart - PMID:12202035 - - - - - down regulation of apoptotic process involved in morphogenesis - GOC:TermGenie - - - - - down-regulation of apoptotic process involved in morphogenesis - GOC:TermGenie - - - - - downregulation of apoptotic process involved in morphogenesis - GOC:TermGenie - - - - - down regulation of apoptosis involved in morphogenesis - GOC:TermGenie - - - - - down-regulation of apoptosis involved in morphogenesis - GOC:TermGenie - - - - - downregulation of apoptosis involved in morphogenesis - GOC:TermGenie - - - - - inhibition of apoptosis involved in morphogenesis - GOC:TermGenie - - - - - inhibition of apoptotic process involved in morphogenesis - GOC:TermGenie - - - - - negative regulation of apoptosis involved in morphogenesis - GOC:TermGenie - - - - - down regulation of apoptosis involved in development - GOC:TermGenie - - - - - down regulation of morphogenetic apoptosis - GOC:TermGenie - - - - - down-regulation of apoptosis involved in development - GOC:TermGenie - - - - - down-regulation of morphogenetic apoptosis - GOC:TermGenie - - - - - downregulation of apoptosis involved in development - GOC:TermGenie - - - - - downregulation of morphogenetic apoptosis - GOC:TermGenie - - - - - inhibition of apoptosis involved in development - GOC:TermGenie - - - - - inhibition of morphogenetic apoptosis - GOC:TermGenie - - - - - negative regulation of apoptosis involved in development - GOC:TermGenie - - - - - negative regulation of morphogenetic apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis. - sart - 2013-07-29T15:03:33Z - up regulation of apoptotic process involved in morphogenesis - up-regulation of apoptotic process involved in morphogenesis - upregulation of apoptotic process involved in morphogenesis - activation of apoptosis involved in morphogenesis - activation of apoptotic process involved in morphogenesis - positive regulation of apoptosis involved in morphogenesis - up regulation of apoptosis involved in morphogenesis - up-regulation of apoptosis involved in morphogenesis - upregulation of apoptosis involved in morphogenesis - biological_process - activation of apoptosis involved in development - activation of morphogenetic apoptosis - positive regulation of apoptosis involved in development - positive regulation of morphogenetic apoptosis - up regulation of apoptosis involved in development - up regulation of morphogenetic apoptosis - up-regulation of apoptosis involved in development - up-regulation of morphogenetic apoptosis - upregulation of apoptosis involved in development - upregulation of morphogenetic apoptosis - GO:1902339 - positive regulation of apoptotic process involved in morphogenesis - - - - - Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis. - GOC:TermGenie - GOC:sart - PMID:12202035 - - - - - up regulation of apoptotic process involved in morphogenesis - GOC:TermGenie - - - - - up-regulation of apoptotic process involved in morphogenesis - GOC:TermGenie - - - - - upregulation of apoptotic process involved in morphogenesis - GOC:TermGenie - - - - - activation of apoptosis involved in morphogenesis - GOC:TermGenie - - - - - activation of apoptotic process involved in morphogenesis - GOC:TermGenie - - - - - positive regulation of apoptosis involved in morphogenesis - GOC:TermGenie - - - - - up regulation of apoptosis involved in morphogenesis - GOC:TermGenie - - - - - up-regulation of apoptosis involved in morphogenesis - GOC:TermGenie - - - - - upregulation of apoptosis involved in morphogenesis - GOC:TermGenie - - - - - activation of apoptosis involved in development - GOC:TermGenie - - - - - activation of morphogenetic apoptosis - GOC:TermGenie - - - - - positive regulation of apoptosis involved in development - GOC:TermGenie - - - - - positive regulation of morphogenetic apoptosis - GOC:TermGenie - - - - - up regulation of apoptosis involved in development - GOC:TermGenie - - - - - up regulation of morphogenetic apoptosis - GOC:TermGenie - - - - - up-regulation of apoptosis involved in development - GOC:TermGenie - - - - - up-regulation of morphogenetic apoptosis - GOC:TermGenie - - - - - upregulation of apoptosis involved in development - GOC:TermGenie - - - - - upregulation of morphogenetic apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation. - dgf - 2013-07-29T20:54:14Z - down regulation of chromosome condensation - down regulation of eukaryotic chromosome condensation - down regulation of nuclear chromosome condensation - down-regulation of chromosome condensation - down-regulation of eukaryotic chromosome condensation - down-regulation of nuclear chromosome condensation - downregulation of chromosome condensation - downregulation of eukaryotic chromosome condensation - downregulation of nuclear chromosome condensation - negative regulation of eukaryotic chromosome condensation - negative regulation of nuclear chromosome condensation - inhibition of chromosome condensation - inhibition of eukaryotic chromosome condensation - inhibition of nuclear chromosome condensation - biological_process - GO:1902340 - negative regulation of chromosome condensation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation. - GOC:TermGenie - PMID:23219725 - - - - - down regulation of chromosome condensation - GOC:TermGenie - - - - - down regulation of eukaryotic chromosome condensation - GOC:TermGenie - - - - - down regulation of nuclear chromosome condensation - GOC:TermGenie - - - - - down-regulation of chromosome condensation - GOC:TermGenie - - - - - down-regulation of eukaryotic chromosome condensation - GOC:TermGenie - - - - - down-regulation of nuclear chromosome condensation - GOC:TermGenie - - - - - downregulation of chromosome condensation - GOC:TermGenie - - - - - downregulation of eukaryotic chromosome condensation - GOC:TermGenie - - - - - downregulation of nuclear chromosome condensation - GOC:TermGenie - - - - - negative regulation of eukaryotic chromosome condensation - GOC:TermGenie - - - - - negative regulation of nuclear chromosome condensation - GOC:TermGenie - - - - - inhibition of chromosome condensation - GOC:TermGenie - - - - - inhibition of eukaryotic chromosome condensation - GOC:TermGenie - - - - - inhibition of nuclear chromosome condensation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of sulfate across a membrane. - dph - 2013-08-14T14:46:04Z - biological_process - GO:1902358 - sulfate transmembrane transport - - - - - The directed movement of sulfate across a membrane. - GOC:TermGenie - GOC:dph - PMID:9055073 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process. - bf - 2013-08-22T14:59:39Z - down regulation of RNA breakdown - down regulation of RNA catabolic process - down regulation of RNA catabolism - down regulation of RNA degradation - down-regulation of RNA breakdown - down-regulation of RNA catabolic process - down-regulation of RNA catabolism - down-regulation of RNA degradation - downregulation of RNA breakdown - downregulation of RNA catabolic process - downregulation of RNA catabolism - downregulation of RNA degradation - negative regulation of RNA breakdown - negative regulation of RNA catabolism - negative regulation of RNA degradation - inhibition of RNA breakdown - inhibition of RNA catabolic process - inhibition of RNA catabolism - inhibition of RNA degradation - biological_process - GO:1902369 - negative regulation of RNA catabolic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process. - GOC:TermGenie - GOC:bf - PMID:16640457 - - - - - down regulation of RNA breakdown - GOC:TermGenie - - - - - down regulation of RNA catabolic process - GOC:TermGenie - - - - - down regulation of RNA catabolism - GOC:TermGenie - - - - - down regulation of RNA degradation - GOC:TermGenie - - - - - down-regulation of RNA breakdown - GOC:TermGenie - - - - - down-regulation of RNA catabolic process - GOC:TermGenie - - - - - down-regulation of RNA catabolism - GOC:TermGenie - - - - - down-regulation of RNA degradation - GOC:TermGenie - - - - - downregulation of RNA breakdown - GOC:TermGenie - - - - - downregulation of RNA catabolic process - GOC:TermGenie - - - - - downregulation of RNA catabolism - GOC:TermGenie - - - - - downregulation of RNA degradation - GOC:TermGenie - - - - - negative regulation of RNA breakdown - GOC:TermGenie - - - - - negative regulation of RNA catabolism - GOC:TermGenie - - - - - negative regulation of RNA degradation - GOC:TermGenie - - - - - inhibition of RNA breakdown - GOC:TermGenie - - - - - inhibition of RNA catabolic process - GOC:TermGenie - - - - - inhibition of RNA catabolism - GOC:TermGenie - - - - - inhibition of RNA degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, a location within a cell junction. - tb - 2013-09-13T16:55:57Z - protein localisation in cell junction - protein localisation to cell junction - protein localization in cell junction - biological_process - GO:1902414 - protein localization to cell junction - - - - - A process in which a protein is transported to, or maintained in, a location within a cell junction. - GOC:TermGenie - PMID:18332111 - - - - - protein localisation in cell junction - GOC:TermGenie - - - - - protein localisation to cell junction - GOC:TermGenie - - - - - protein localization in cell junction - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, a location within a cell leading edge. - jl - 2013-10-22T12:36:07Z - protein localisation in cell leading edge - protein localisation to cell leading edge - protein localization in cell leading edge - biological_process - GO:1902463 - protein localization to cell leading edge - - - - - A process in which a protein is transported to, or maintained in, a location within a cell leading edge. - GOC:TermGenie - GOC:lb - PMID:21543326 - - - - - protein localisation in cell leading edge - GOC:TermGenie - - - - - protein localisation to cell leading edge - GOC:TermGenie - - - - - protein localization in cell leading edge - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of protein localization to synapse. - kmv - 2013-10-25T15:09:09Z - regulation of protein localisation to synapse - biological_process - GO:1902473 - regulation of protein localization to synapse - - - - - Any process that modulates the frequency, rate or extent of protein localization to synapse. - GOC:TermGenie - GOC:kmv - PMID:22588719 - - - - - regulation of protein localisation to synapse - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to synapse. - kmv - 2013-10-25T15:09:18Z - positive regulation of protein localisation to synapse - up regulation of protein localisation to synapse - up regulation of protein localization to synapse - up-regulation of protein localisation to synapse - up-regulation of protein localization to synapse - upregulation of protein localisation to synapse - upregulation of protein localization to synapse - activation of protein localisation to synapse - activation of protein localization to synapse - biological_process - GO:1902474 - positive regulation of protein localization to synapse - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to synapse. - GOC:TermGenie - GOC:kmv - PMID:22588719 - - - - - positive regulation of protein localisation to synapse - GOC:TermGenie - - - - - up regulation of protein localisation to synapse - GOC:TermGenie - - - - - up regulation of protein localization to synapse - GOC:TermGenie - - - - - up-regulation of protein localisation to synapse - GOC:TermGenie - - - - - up-regulation of protein localization to synapse - GOC:TermGenie - - - - - upregulation of protein localisation to synapse - GOC:TermGenie - - - - - upregulation of protein localization to synapse - GOC:TermGenie - - - - - activation of protein localisation to synapse - GOC:TermGenie - - - - - activation of protein localization to synapse - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in a cholangiocyte. - cls - 2013-11-12T15:30:08Z - epithelial cell of bile duct apoptotic process - cholangiocyte apoptosis - epithelial cell of bile duct apoptosis - biological_process - GO:1902488 - cholangiocyte apoptotic process - - - - - Any apoptotic process in a cholangiocyte. - GOC:TermGenie - PMID:22961800 - - - - - epithelial cell of bile duct apoptotic process - GOC:TermGenie - - - - - cholangiocyte apoptosis - GOC:TermGenie - - - - - epithelial cell of bile duct apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in a hepatoblast. - cls - 2013-11-12T17:02:52Z - hepatoblast apoptosis - biological_process - GO:1902489 - hepatoblast apoptotic process - - - - - Any apoptotic process in a hepatoblast. - GOC:TermGenie - PMID:22412967 - - - - - hepatoblast apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - A protein complex which is capable of catalytic activity. - https://github.com/geneontology/go-ontology/issues/19980 - bhm - 2013-11-13T16:18:47Z - enzyme complex - cellular_component - GO:1902494 - - catalytic complex - - - - - A protein complex which is capable of catalytic activity. - GOC:TermGenie - GOC:bhm - PMID:8077207 - - - - - enzyme complex - GOC:bhm - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. - bhm - 2013-11-13T16:23:04Z - cellular_component - GO:1902495 - transmembrane transporter complex - - - - - A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. - GOC:TermGenie - GOC:bhm - PMID:18024586 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation. - hjd - 2013-11-15T18:28:32Z - regulation of DNA fragmentation - regulation of chromatinolysis - regulation of DNA catabolic process during apoptosis - regulation of DNA catabolism during apoptosis - regulation of DNA fragmentation involved in apoptotic nuclear change - regulation of endonucleolytic DNA catabolic process involved in apoptosis - biological_process - GO:1902510 - DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases (see GO:0006309 'apoptotic DNA fragmentation'). Gene products involved in compartmentalization of such nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). - regulation of apoptotic DNA fragmentation - - - - - Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation. - GOC:TermGenie - GOC:hjd - PMID:15572351 - PMID:15723341 - - - - - regulation of DNA fragmentation - GOC:TermGenie - - - - - regulation of chromatinolysis - GOC:TermGenie - - - - - regulation of DNA catabolic process during apoptosis - GOC:TermGenie - - - - - regulation of DNA catabolism during apoptosis - GOC:TermGenie - - - - - regulation of DNA fragmentation involved in apoptotic nuclear change - GOC:TermGenie - - - - - regulation of endonucleolytic DNA catabolic process involved in apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation. - hjd - 2013-11-15T18:28:41Z - down regulation of DNA catabolic process during apoptosis - down regulation of DNA catabolism during apoptosis - down regulation of DNA fragmentation involved in apoptotic nuclear change - down regulation of apoptotic DNA fragmentation - down regulation of endonucleolytic DNA catabolic process involved in apoptosis - down-regulation of DNA catabolic process during apoptosis - down-regulation of DNA catabolism during apoptosis - down-regulation of DNA fragmentation involved in apoptotic nuclear change - down-regulation of apoptotic DNA fragmentation - down-regulation of endonucleolytic DNA catabolic process involved in apoptosis - downregulation of DNA catabolic process during apoptosis - downregulation of DNA catabolism during apoptosis - downregulation of DNA fragmentation involved in apoptotic nuclear change - downregulation of apoptotic DNA fragmentation - downregulation of endonucleolytic DNA catabolic process involved in apoptosis - negative regulation of DNA catabolic process during apoptosis - negative regulation of DNA catabolism during apoptosis - negative regulation of DNA fragmentation involved in apoptotic nuclear change - negative regulation of endonucleolytic DNA catabolic process involved in apoptosis - inhibition of DNA catabolic process during apoptosis - inhibition of DNA catabolism during apoptosis - inhibition of DNA fragmentation involved in apoptotic nuclear change - inhibition of apoptotic DNA fragmentation - inhibition of endonucleolytic DNA catabolic process involved in apoptosis - biological_process - GO:1902511 - negative regulation of apoptotic DNA fragmentation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation. - GOC:TermGenie - GOC:hjd - PMID:15572351 - - - - - down regulation of DNA catabolic process during apoptosis - GOC:TermGenie - - - - - down regulation of DNA catabolism during apoptosis - GOC:TermGenie - - - - - down regulation of DNA fragmentation involved in apoptotic nuclear change - GOC:TermGenie - - - - - down regulation of apoptotic DNA fragmentation - GOC:TermGenie - - - - - down regulation of endonucleolytic DNA catabolic process involved in apoptosis - GOC:TermGenie - - - - - down-regulation of DNA catabolic process during apoptosis - GOC:TermGenie - - - - - down-regulation of DNA catabolism during apoptosis - GOC:TermGenie - - - - - down-regulation of DNA fragmentation involved in apoptotic nuclear change - GOC:TermGenie - - - - - down-regulation of apoptotic DNA fragmentation - GOC:TermGenie - - - - - down-regulation of endonucleolytic DNA catabolic process involved in apoptosis - GOC:TermGenie - - - - - downregulation of DNA catabolic process during apoptosis - GOC:TermGenie - - - - - downregulation of DNA catabolism during apoptosis - GOC:TermGenie - - - - - downregulation of DNA fragmentation involved in apoptotic nuclear change - GOC:TermGenie - - - - - downregulation of apoptotic DNA fragmentation - GOC:TermGenie - - - - - downregulation of endonucleolytic DNA catabolic process involved in apoptosis - GOC:TermGenie - - - - - negative regulation of DNA catabolic process during apoptosis - GOC:TermGenie - - - - - negative regulation of DNA catabolism during apoptosis - GOC:TermGenie - - - - - negative regulation of DNA fragmentation involved in apoptotic nuclear change - GOC:TermGenie - - - - - negative regulation of endonucleolytic DNA catabolic process involved in apoptosis - GOC:TermGenie - - - - - inhibition of DNA catabolic process during apoptosis - GOC:TermGenie - - - - - inhibition of DNA catabolism during apoptosis - GOC:TermGenie - - - - - inhibition of DNA fragmentation involved in apoptotic nuclear change - GOC:TermGenie - - - - - inhibition of apoptotic DNA fragmentation - GOC:TermGenie - - - - - inhibition of endonucleolytic DNA catabolic process involved in apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation. - hjd - 2013-11-15T18:28:50Z - positive regulation of DNA catabolic process during apoptosis - positive regulation of DNA catabolism during apoptosis - positive regulation of DNA fragmentation involved in apoptotic nuclear change - positive regulation of endonucleolytic DNA catabolic process involved in apoptosis - up regulation of DNA catabolic process during apoptosis - up regulation of DNA catabolism during apoptosis - up regulation of DNA fragmentation involved in apoptotic nuclear change - up regulation of apoptotic DNA fragmentation - up regulation of endonucleolytic DNA catabolic process involved in apoptosis - up-regulation of DNA catabolic process during apoptosis - up-regulation of DNA catabolism during apoptosis - up-regulation of DNA fragmentation involved in apoptotic nuclear change - up-regulation of apoptotic DNA fragmentation - up-regulation of endonucleolytic DNA catabolic process involved in apoptosis - upregulation of DNA catabolic process during apoptosis - upregulation of DNA catabolism during apoptosis - upregulation of DNA fragmentation involved in apoptotic nuclear change - upregulation of apoptotic DNA fragmentation - upregulation of endonucleolytic DNA catabolic process involved in apoptosis - activation of DNA catabolic process during apoptosis - activation of DNA catabolism during apoptosis - activation of DNA fragmentation involved in apoptotic nuclear change - activation of apoptotic DNA fragmentation - activation of endonucleolytic DNA catabolic process involved in apoptosis - biological_process - GO:1902512 - positive regulation of apoptotic DNA fragmentation - - - - - Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation. - GOC:TermGenie - GOC:hjd - PMID:15572351 - - - - - positive regulation of DNA catabolic process during apoptosis - GOC:TermGenie - - - - - positive regulation of DNA catabolism during apoptosis - GOC:TermGenie - - - - - positive regulation of DNA fragmentation involved in apoptotic nuclear change - GOC:TermGenie - - - - - positive regulation of endonucleolytic DNA catabolic process involved in apoptosis - GOC:TermGenie - - - - - up regulation of DNA catabolic process during apoptosis - GOC:TermGenie - - - - - up regulation of DNA catabolism during apoptosis - GOC:TermGenie - - - - - up regulation of DNA fragmentation involved in apoptotic nuclear change - GOC:TermGenie - - - - - up regulation of apoptotic DNA fragmentation - GOC:TermGenie - - - - - up regulation of endonucleolytic DNA catabolic process involved in apoptosis - GOC:TermGenie - - - - - up-regulation of DNA catabolic process during apoptosis - GOC:TermGenie - - - - - up-regulation of DNA catabolism during apoptosis - GOC:TermGenie - - - - - up-regulation of DNA fragmentation involved in apoptotic nuclear change - GOC:TermGenie - - - - - up-regulation of apoptotic DNA fragmentation - GOC:TermGenie - - - - - up-regulation of endonucleolytic DNA catabolic process involved in apoptosis - GOC:TermGenie - - - - - upregulation of DNA catabolic process during apoptosis - GOC:TermGenie - - - - - upregulation of DNA catabolism during apoptosis - GOC:TermGenie - - - - - upregulation of DNA fragmentation involved in apoptotic nuclear change - GOC:TermGenie - - - - - upregulation of apoptotic DNA fragmentation - GOC:TermGenie - - - - - upregulation of endonucleolytic DNA catabolic process involved in apoptosis - GOC:TermGenie - - - - - activation of DNA catabolic process during apoptosis - GOC:TermGenie - - - - - activation of DNA catabolism during apoptosis - GOC:TermGenie - - - - - activation of DNA fragmentation involved in apoptotic nuclear change - GOC:TermGenie - - - - - activation of apoptotic DNA fragmentation - GOC:TermGenie - - - - - activation of endonucleolytic DNA catabolic process involved in apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of organelle transport along microtubule. - dph - 2013-11-15T20:15:17Z - regulation of microtubule-based organelle localization - biological_process - GO:1902513 - regulation of organelle transport along microtubule - - - - - Any process that modulates the frequency, rate or extent of organelle transport along microtubule. - GOC:TermGenie - GOC:dph - PMID:21147087 - - - - - regulation of microtubule-based organelle localization - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of intracellular signal transduction. - bf - 2013-12-02T11:32:52Z - GO:0010627 - regulation of intracellular signaling cascade - regulation of intracellular signaling chain - regulation of intracellular protein kinase cascade - regulation of intracellular signal transduction pathway - regulation of signal transmission via intracellular cascade - biological_process - regulation of intracellular signaling pathway - regulation of signal transduction via intracellular signaling cascade - GO:1902531 - regulation of intracellular signal transduction - - - - - Any process that modulates the frequency, rate or extent of intracellular signal transduction. - GOC:TermGenie - GOC:dph - GOC:signaling - GOC:tb - - - - - regulation of intracellular signaling cascade - GOC:TermGenie - - - - - regulation of intracellular signaling chain - GOC:TermGenie - - - - - regulation of intracellular signal transduction pathway - GOC:TermGenie - - - - - regulation of signal transmission via intracellular cascade - GOC:TermGenie - - - - - regulation of intracellular signaling pathway - GOC:TermGenie - - - - - regulation of signal transduction via intracellular signaling cascade - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. - bf - 2013-12-02T11:33:01Z - GO:0010741 - down regulation of intracellular signal transduction - down regulation of intracellular signaling chain - down-regulation of intracellular signal transduction - down-regulation of intracellular signaling chain - downregulation of intracellular signal transduction - downregulation of intracellular signaling chain - negative regulation of intracellular protein kinase cascade - negative regulation of intracellular signaling cascade - negative regulation of intracellular signaling chain - down regulation of intracellular signal transduction pathway - down regulation of intracellular signaling cascade - down regulation of signal transmission via intracellular cascade - down-regulation of intracellular signal transduction pathway - downregulation of intracellular signal transduction pathway - downregulation of intracellular signaling cascade - downregulation of signal transmission via intracellular cascade - inhibition of intracellular signal transduction - inhibition of intracellular signal transduction pathway - inhibition of intracellular signaling cascade - inhibition of intracellular signaling chain - inhibition of signal transmission via intracellular cascade - negative regulation of intracellular signal transduction pathway - negative regulation of signal transmission via intracellular cascade - biological_process - down regulation of intracellular signaling pathway - down regulation of signal transduction via intracellular signaling cascade - down-regulation of intracellular signaling cascade - down-regulation of intracellular signaling pathway - down-regulation of signal transduction via intracellular signaling cascade - down-regulation of signal transmission via intracellular cascade - downregulation of intracellular signaling pathway - downregulation of signal transduction via intracellular signaling cascade - inhibition of intracellular signaling pathway - inhibition of signal transduction via intracellular signaling cascade - negative regulation of intracellular signaling pathway - negative regulation of signal transduction via intracellular signaling cascade - GO:1902532 - negative regulation of intracellular signal transduction - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. - GOC:TermGenie - GOC:dph - GOC:signaling - GOC:tb - - - - - down regulation of intracellular signal transduction - GOC:TermGenie - - - - - down regulation of intracellular signaling chain - GOC:TermGenie - - - - - down-regulation of intracellular signal transduction - GOC:TermGenie - - - - - down-regulation of intracellular signaling chain - GOC:TermGenie - - - - - downregulation of intracellular signal transduction - GOC:TermGenie - - - - - downregulation of intracellular signaling chain - GOC:TermGenie - - - - - negative regulation of intracellular signaling cascade - GOC:TermGenie - - - - - negative regulation of intracellular signaling chain - GOC:TermGenie - - - - - down regulation of intracellular signal transduction pathway - GOC:TermGenie - - - - - down regulation of intracellular signaling cascade - GOC:TermGenie - - - - - down regulation of signal transmission via intracellular cascade - GOC:TermGenie - - - - - down-regulation of intracellular signal transduction pathway - GOC:TermGenie - - - - - downregulation of intracellular signal transduction pathway - GOC:TermGenie - - - - - downregulation of intracellular signaling cascade - GOC:TermGenie - - - - - downregulation of signal transmission via intracellular cascade - GOC:TermGenie - - - - - inhibition of intracellular signal transduction - GOC:TermGenie - - - - - inhibition of intracellular signal transduction pathway - GOC:TermGenie - - - - - inhibition of intracellular signaling cascade - GOC:TermGenie - - - - - inhibition of intracellular signaling chain - GOC:TermGenie - - - - - inhibition of signal transmission via intracellular cascade - GOC:TermGenie - - - - - negative regulation of intracellular signal transduction pathway - GOC:TermGenie - - - - - negative regulation of signal transmission via intracellular cascade - GOC:TermGenie - - - - - down regulation of intracellular signaling pathway - GOC:TermGenie - - - - - down regulation of signal transduction via intracellular signaling cascade - GOC:TermGenie - - - - - down-regulation of intracellular signaling cascade - GOC:TermGenie - - - - - down-regulation of intracellular signaling pathway - GOC:TermGenie - - - - - down-regulation of signal transduction via intracellular signaling cascade - GOC:TermGenie - - - - - down-regulation of signal transmission via intracellular cascade - GOC:TermGenie - - - - - downregulation of intracellular signaling pathway - GOC:TermGenie - - - - - downregulation of signal transduction via intracellular signaling cascade - GOC:TermGenie - - - - - inhibition of intracellular signaling pathway - GOC:TermGenie - - - - - inhibition of signal transduction via intracellular signaling cascade - GOC:TermGenie - - - - - negative regulation of intracellular signaling pathway - GOC:TermGenie - - - - - negative regulation of signal transduction via intracellular signaling cascade - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. - bf - 2013-12-02T11:33:10Z - GO:0010740 - positive regulation of intracellular signaling chain - up regulation of intracellular signal transduction - up regulation of intracellular signaling chain - up-regulation of intracellular signal transduction - up-regulation of intracellular signaling chain - upregulation of intracellular signal transduction - upregulation of intracellular signaling chain - activation of intracellular signal transduction - activation of intracellular signal transduction pathway - activation of intracellular signaling cascade - activation of intracellular signaling chain - activation of signal transmission via intracellular cascade - positive regulation of intracellular protein kinase cascade - positive regulation of intracellular signal transduction pathway - positive regulation of signal transmission via intracellular cascade - up regulation of intracellular signal transduction pathway - up regulation of signal transmission via intracellular cascade - up-regulation of intracellular signal transduction pathway - up-regulation of signal transmission via intracellular cascade - upregulation of intracellular signal transduction pathway - upregulation of signal transmission via intracellular cascade - biological_process - activation of intracellular signaling pathway - activation of signal transduction via intracellular signaling cascade - positive regulation of intracellular signaling cascade - positive regulation of intracellular signaling pathway - positive regulation of signal transduction via intracellular signaling cascade - up regulation of intracellular signaling cascade - up regulation of intracellular signaling pathway - up regulation of signal transduction via intracellular signaling cascade - up-regulation of intracellular signaling cascade - up-regulation of intracellular signaling pathway - up-regulation of signal transduction via intracellular signaling cascade - upregulation of intracellular signaling cascade - upregulation of intracellular signaling pathway - upregulation of signal transduction via intracellular signaling cascade - GO:1902533 - positive regulation of intracellular signal transduction - - - - - Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. - GOC:BHF - GOC:TermGenie - GOC:dph - GOC:signaling - GOC:tb - - - - - positive regulation of intracellular signaling chain - GOC:TermGenie - - - - - up regulation of intracellular signal transduction - GOC:TermGenie - - - - - up regulation of intracellular signaling chain - GOC:TermGenie - - - - - up-regulation of intracellular signal transduction - GOC:TermGenie - - - - - up-regulation of intracellular signaling chain - GOC:TermGenie - - - - - upregulation of intracellular signal transduction - GOC:TermGenie - - - - - upregulation of intracellular signaling chain - GOC:TermGenie - - - - - activation of intracellular signal transduction - GOC:TermGenie - - - - - activation of intracellular signal transduction pathway - GOC:TermGenie - - - - - activation of intracellular signaling cascade - GOC:TermGenie - - - - - activation of intracellular signaling chain - GOC:TermGenie - - - - - activation of signal transmission via intracellular cascade - GOC:TermGenie - - - - - positive regulation of intracellular signal transduction pathway - GOC:TermGenie - - - - - positive regulation of signal transmission via intracellular cascade - GOC:TermGenie - - - - - up regulation of intracellular signal transduction pathway - GOC:TermGenie - - - - - up regulation of signal transmission via intracellular cascade - GOC:TermGenie - - - - - up-regulation of intracellular signal transduction pathway - GOC:TermGenie - - - - - up-regulation of signal transmission via intracellular cascade - GOC:TermGenie - - - - - upregulation of intracellular signal transduction pathway - GOC:TermGenie - - - - - upregulation of signal transmission via intracellular cascade - GOC:TermGenie - - - - - activation of intracellular signaling pathway - GOC:TermGenie - - - - - activation of signal transduction via intracellular signaling cascade - GOC:TermGenie - - - - - positive regulation of intracellular signaling cascade - GOC:TermGenie - - - - - positive regulation of intracellular signaling pathway - GOC:TermGenie - - - - - positive regulation of signal transduction via intracellular signaling cascade - GOC:TermGenie - - - - - up regulation of intracellular signaling cascade - GOC:TermGenie - - - - - up regulation of intracellular signaling pathway - GOC:TermGenie - - - - - up regulation of signal transduction via intracellular signaling cascade - GOC:TermGenie - - - - - up-regulation of intracellular signaling cascade - GOC:TermGenie - - - - - up-regulation of intracellular signaling pathway - GOC:TermGenie - - - - - up-regulation of signal transduction via intracellular signaling cascade - GOC:TermGenie - - - - - upregulation of intracellular signaling cascade - GOC:TermGenie - - - - - upregulation of intracellular signaling pathway - GOC:TermGenie - - - - - upregulation of signal transduction via intracellular signaling cascade - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, a location within a nucleolus. - mah - 2013-12-10T16:25:28Z - protein localisation in nucleolus - protein localisation to nucleolus - protein localization in nucleolus - biological_process - GO:1902570 - protein localization to nucleolus - - - - - A process in which a protein is transported to, or maintained in, a location within a nucleolus. - GOC:TermGenie - PMID:22809626 - - - - - protein localisation in nucleolus - GOC:TermGenie - - - - - protein localisation to nucleolus - GOC:TermGenie - - - - - protein localization in nucleolus - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process. - jl - 2014-02-05T16:32:01Z - down regulation of RNA anabolism - down regulation of RNA biosynthesis - down regulation of RNA biosynthetic process - down regulation of RNA formation - down regulation of RNA synthesis - down-regulation of RNA anabolism - down-regulation of RNA biosynthesis - down-regulation of RNA biosynthetic process - down-regulation of RNA formation - down-regulation of RNA synthesis - downregulation of RNA anabolism - downregulation of RNA biosynthesis - downregulation of RNA biosynthetic process - downregulation of RNA formation - downregulation of RNA synthesis - negative regulation of RNA anabolism - negative regulation of RNA biosynthesis - negative regulation of RNA formation - negative regulation of RNA synthesis - inhibition of RNA anabolism - inhibition of RNA biosynthesis - inhibition of RNA biosynthetic process - inhibition of RNA formation - inhibition of RNA synthesis - biological_process - GO:1902679 - negative regulation of RNA biosynthetic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process. - GO:jl - GOC:TermGenie - GO_REF:0000058 - - - - - down regulation of RNA anabolism - GOC:TermGenie - - - - - down regulation of RNA biosynthesis - GOC:TermGenie - - - - - down regulation of RNA biosynthetic process - GOC:TermGenie - - - - - down regulation of RNA formation - GOC:TermGenie - - - - - down regulation of RNA synthesis - GOC:TermGenie - - - - - down-regulation of RNA anabolism - GOC:TermGenie - - - - - down-regulation of RNA biosynthesis - GOC:TermGenie - - - - - down-regulation of RNA biosynthetic process - GOC:TermGenie - - - - - down-regulation of RNA formation - GOC:TermGenie - - - - - down-regulation of RNA synthesis - GOC:TermGenie - - - - - downregulation of RNA anabolism - GOC:TermGenie - - - - - downregulation of RNA biosynthesis - GOC:TermGenie - - - - - downregulation of RNA biosynthetic process - GOC:TermGenie - - - - - downregulation of RNA formation - GOC:TermGenie - - - - - downregulation of RNA synthesis - GOC:TermGenie - - - - - negative regulation of RNA anabolism - GOC:TermGenie - - - - - negative regulation of RNA biosynthesis - GOC:TermGenie - - - - - negative regulation of RNA formation - GOC:TermGenie - - - - - negative regulation of RNA synthesis - GOC:TermGenie - - - - - inhibition of RNA anabolism - GOC:TermGenie - - - - - inhibition of RNA biosynthesis - GOC:TermGenie - - - - - inhibition of RNA biosynthetic process - GOC:TermGenie - - - - - inhibition of RNA formation - GOC:TermGenie - - - - - inhibition of RNA synthesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process. - jl - 2014-02-05T16:32:10Z - positive regulation of RNA anabolism - positive regulation of RNA biosynthesis - positive regulation of RNA formation - positive regulation of RNA synthesis - up regulation of RNA anabolism - up regulation of RNA biosynthesis - up regulation of RNA biosynthetic process - up regulation of RNA formation - up regulation of RNA synthesis - up-regulation of RNA anabolism - up-regulation of RNA biosynthesis - up-regulation of RNA biosynthetic process - up-regulation of RNA formation - up-regulation of RNA synthesis - upregulation of RNA anabolism - upregulation of RNA biosynthesis - upregulation of RNA biosynthetic process - upregulation of RNA formation - upregulation of RNA synthesis - activation of RNA anabolism - activation of RNA biosynthesis - activation of RNA biosynthetic process - activation of RNA formation - activation of RNA synthesis - biological_process - GO:1902680 - positive regulation of RNA biosynthetic process - - - - - Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process. - GO:jl - GOC:TermGenie - GO_REF:0000058 - - - - - positive regulation of RNA anabolism - GOC:TermGenie - - - - - positive regulation of RNA biosynthesis - GOC:TermGenie - - - - - positive regulation of RNA formation - GOC:TermGenie - - - - - positive regulation of RNA synthesis - GOC:TermGenie - - - - - up regulation of RNA anabolism - GOC:TermGenie - - - - - up regulation of RNA biosynthesis - GOC:TermGenie - - - - - up regulation of RNA biosynthetic process - GOC:TermGenie - - - - - up regulation of RNA formation - GOC:TermGenie - - - - - up regulation of RNA synthesis - GOC:TermGenie - - - - - up-regulation of RNA anabolism - GOC:TermGenie - - - - - up-regulation of RNA biosynthesis - GOC:TermGenie - - - - - up-regulation of RNA biosynthetic process - GOC:TermGenie - - - - - up-regulation of RNA formation - GOC:TermGenie - - - - - up-regulation of RNA synthesis - GOC:TermGenie - - - - - upregulation of RNA anabolism - GOC:TermGenie - - - - - upregulation of RNA biosynthesis - GOC:TermGenie - - - - - upregulation of RNA biosynthetic process - GOC:TermGenie - - - - - upregulation of RNA formation - GOC:TermGenie - - - - - upregulation of RNA synthesis - GOC:TermGenie - - - - - activation of RNA anabolism - GOC:TermGenie - - - - - activation of RNA biosynthesis - GOC:TermGenie - - - - - activation of RNA biosynthetic process - GOC:TermGenie - - - - - activation of RNA formation - GOC:TermGenie - - - - - activation of RNA synthesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of neuroblast proliferation. - rl - 2014-02-18T10:03:31Z - biological_process - GO:1902692 - regulation of neuroblast proliferation - - - - - Any process that modulates the frequency, rate or extent of neuroblast proliferation. - GOC:PARL - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:21168496 - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. - mr - 2014-02-26T15:36:15Z - biological_process - GO:1902738 - regulation of chondrocyte differentiation involved in endochondral bone morphogenesis - - - - - Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. - GOC:TermGenie - GO_REF:0000058 - PMID:8662546 - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process that is involved in anatomical structure development. - pr - 2014-02-28T13:09:43Z - apoptotic cell death involved in anatomical structure development - apoptotic cell death involved in development of an anatomical structure - apoptotic process involved in anatomical structure development - apoptotic process involved in development of an anatomical structure - apoptotic programmed cell death involved in anatomical structure development - apoptotic programmed cell death involved in development of an anatomical structure - programmed cell death by apoptosis involved in anatomical structure development - programmed cell death by apoptosis involved in development of an anatomical structure - activation of apoptosis involved in anatomical structure development - activation of apoptosis involved in development of an anatomical structure - apoptosis involved in anatomical structure development - apoptosis involved in development of an anatomical structure - apoptosis signaling involved in anatomical structure development - apoptosis signaling involved in development of an anatomical structure - apoptotic program involved in anatomical structure development - apoptotic program involved in development of an anatomical structure - type I programmed cell death involved in anatomical structure development - type I programmed cell death involved in development of an anatomical structure - biological_process - apoptosis activator activity involved in anatomical structure development - apoptosis activator activity involved in development of an anatomical structure - commitment to apoptosis involved in anatomical structure development - commitment to apoptosis involved in development of an anatomical structure - induction of apoptosis by p53 involved in anatomical structure development - induction of apoptosis by p53 involved in development of an anatomical structure - induction of apoptosis involved in anatomical structure development - induction of apoptosis involved in development of an anatomical structure - signaling (initiator) caspase activity involved in anatomical structure development - signaling (initiator) caspase activity involved in development of an anatomical structure - GO:1902742 - apoptotic process involved in development - - - - - Any apoptotic process that is involved in anatomical structure development. - GOC:TermGenie - GOC:mtg_apoptosis - GOC:pg - GO_REF:0000060 - - - - - apoptotic cell death involved in anatomical structure development - GOC:TermGenie - - - - - apoptotic cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - apoptotic process involved in development of an anatomical structure - GOC:TermGenie - - - - - apoptotic programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - apoptotic programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - programmed cell death by apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - programmed cell death by apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - activation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - activation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - apoptosis signaling involved in anatomical structure development - GOC:TermGenie - - - - - apoptosis signaling involved in development of an anatomical structure - GOC:TermGenie - - - - - apoptotic program involved in anatomical structure development - GOC:TermGenie - - - - - apoptotic program involved in development of an anatomical structure - GOC:TermGenie - - - - - type I programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - type I programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - apoptosis activator activity involved in anatomical structure development - GOC:TermGenie - - - - - apoptosis activator activity involved in development of an anatomical structure - GOC:TermGenie - - - - - commitment to apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - commitment to apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - induction of apoptosis by p53 involved in anatomical structure development - GOC:TermGenie - - - - - induction of apoptosis by p53 involved in development of an anatomical structure - GOC:TermGenie - - - - - induction of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - induction of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - signaling (initiator) caspase activity involved in anatomical structure development - GOC:TermGenie - - - - - signaling (initiator) caspase activity involved in development of an anatomical structure - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of chondrocyte development. - mr - 2014-03-07T17:45:55Z - up regulation of chondrocyte development - up-regulation of chondrocyte development - upregulation of chondrocyte development - activation of chondrocyte development - biological_process - GO:1902761 - positive regulation of chondrocyte development - - - - - Any process that activates or increases the frequency, rate or extent of chondrocyte development. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:16575901 - - - - - up regulation of chondrocyte development - GOC:TermGenie - - - - - up-regulation of chondrocyte development - GOC:TermGenie - - - - - upregulation of chondrocyte development - GOC:TermGenie - - - - - activation of chondrocyte development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation. - mr - 2014-03-26T21:18:26Z - biological_process - GO:1902809 - regulation of skeletal muscle fiber differentiation - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:17879321 - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation. - mr - 2014-03-26T21:18:32Z - down regulation of skeletal muscle fiber differentiation - down-regulation of skeletal muscle fiber differentiation - downregulation of skeletal muscle fiber differentiation - inhibition of skeletal muscle fiber differentiation - biological_process - GO:1902810 - negative regulation of skeletal muscle fiber differentiation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:17879321 - - - - - down regulation of skeletal muscle fiber differentiation - GOC:TermGenie - - - - - down-regulation of skeletal muscle fiber differentiation - GOC:TermGenie - - - - - downregulation of skeletal muscle fiber differentiation - GOC:TermGenie - - - - - inhibition of skeletal muscle fiber differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation. - mr - 2014-03-26T21:18:38Z - up regulation of skeletal muscle fiber differentiation - up-regulation of skeletal muscle fiber differentiation - upregulation of skeletal muscle fiber differentiation - activation of skeletal muscle fiber differentiation - biological_process - GO:1902811 - positive regulation of skeletal muscle fiber differentiation - - - - - Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:17879321 - - - - - up regulation of skeletal muscle fiber differentiation - GOC:TermGenie - - - - - up-regulation of skeletal muscle fiber differentiation - GOC:TermGenie - - - - - upregulation of skeletal muscle fiber differentiation - GOC:TermGenie - - - - - activation of skeletal muscle fiber differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of protein localization to microtubule. - tb - 2014-03-27T22:07:12Z - regulation of protein localisation to microtubule - biological_process - GO:1902816 - regulation of protein localization to microtubule - - - - - Any process that modulates the frequency, rate or extent of protein localization to microtubule. - GOC:TermGenie - GOC:vw - GO_REF:0000058 - PMID:23087209 - - - - - regulation of protein localisation to microtubule - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule. - tb - 2014-03-27T22:07:18Z - down regulation of protein localisation to microtubule - down regulation of protein localization to microtubule - down-regulation of protein localisation to microtubule - down-regulation of protein localization to microtubule - downregulation of protein localisation to microtubule - downregulation of protein localization to microtubule - negative regulation of protein localisation to microtubule - inhibition of protein localisation to microtubule - inhibition of protein localization to microtubule - biological_process - GO:1902817 - negative regulation of protein localization to microtubule - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule. - GOC:TermGenie - GOC:vw - GO_REF:0000058 - PMID:23087209 - - - - - down regulation of protein localisation to microtubule - GOC:TermGenie - - - - - down regulation of protein localization to microtubule - GOC:TermGenie - - - - - down-regulation of protein localisation to microtubule - GOC:TermGenie - - - - - down-regulation of protein localization to microtubule - GOC:TermGenie - - - - - downregulation of protein localisation to microtubule - GOC:TermGenie - - - - - downregulation of protein localization to microtubule - GOC:TermGenie - - - - - negative regulation of protein localisation to microtubule - GOC:TermGenie - - - - - inhibition of protein localisation to microtubule - GOC:TermGenie - - - - - inhibition of protein localization to microtubule - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of nuclear migration along microtubule. - vw - 2014-04-01T13:50:23Z - regulation of nuclear movement, microtubule-mediated - regulation of nucleus migration - regulation of microtubule cytoskeleton-dependent nuclear positioning - regulation of microtubule cytoskeleton-dependent nucleus positioning - regulation of microtubule-dependent nuclear positioning - regulation of microtubule-dependent nucleus positioning - regulation of microtubule-mediated nuclear migration - regulation of nuclear migration, microtubule-mediated - regulation of transport of nucleus by microtubules - regulation of transport of nucleus, microtubule-mediated - biological_process - GO:1902838 - regulation of nuclear migration along microtubule - - - - - Any process that modulates the frequency, rate or extent of nuclear migration along microtubule. - GOC:TermGenie - GO_REF:0000058 - PMID:23087209 - - - - - regulation of nuclear movement, microtubule-mediated - GOC:TermGenie - - - - - regulation of nucleus migration - GOC:TermGenie - - - - - regulation of microtubule cytoskeleton-dependent nuclear positioning - GOC:TermGenie - - - - - regulation of microtubule cytoskeleton-dependent nucleus positioning - GOC:TermGenie - - - - - regulation of microtubule-dependent nuclear positioning - GOC:TermGenie - - - - - regulation of microtubule-dependent nucleus positioning - GOC:TermGenie - - - - - regulation of microtubule-mediated nuclear migration - GOC:TermGenie - - - - - regulation of nuclear migration, microtubule-mediated - GOC:TermGenie - - - - - regulation of transport of nucleus by microtubules - GOC:TermGenie - - - - - regulation of transport of nucleus, microtubule-mediated - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule. - vw - 2014-04-01T13:50:29Z - down regulation of microtubule cytoskeleton-dependent nuclear positioning - down regulation of microtubule cytoskeleton-dependent nucleus positioning - down regulation of microtubule-dependent nuclear positioning - down regulation of microtubule-dependent nucleus positioning - down regulation of microtubule-mediated nuclear migration - down regulation of nuclear migration along microtubule - down regulation of nuclear migration, microtubule-mediated - down regulation of transport of nucleus by microtubules - down regulation of transport of nucleus, microtubule-mediated - down-regulation of microtubule cytoskeleton-dependent nuclear positioning - down-regulation of microtubule cytoskeleton-dependent nucleus positioning - down-regulation of microtubule-dependent nuclear positioning - down-regulation of microtubule-dependent nucleus positioning - down-regulation of microtubule-mediated nuclear migration - down-regulation of nuclear migration along microtubule - down-regulation of nuclear migration, microtubule-mediated - down-regulation of transport of nucleus by microtubules - down-regulation of transport of nucleus, microtubule-mediated - downregulation of microtubule cytoskeleton-dependent nuclear positioning - downregulation of microtubule cytoskeleton-dependent nucleus positioning - downregulation of microtubule-dependent nuclear positioning - downregulation of microtubule-dependent nucleus positioning - downregulation of microtubule-mediated nuclear migration - downregulation of nuclear migration along microtubule - downregulation of nuclear migration, microtubule-mediated - downregulation of transport of nucleus by microtubules - downregulation of transport of nucleus, microtubule-mediated - negative regulation of microtubule cytoskeleton-dependent nuclear positioning - negative regulation of microtubule cytoskeleton-dependent nucleus positioning - negative regulation of microtubule-dependent nuclear positioning - negative regulation of microtubule-dependent nucleus positioning - negative regulation of microtubule-mediated nuclear migration - negative regulation of nuclear migration, microtubule-mediated - negative regulation of transport of nucleus by microtubules - negative regulation of transport of nucleus, microtubule-mediated - inhibition of microtubule cytoskeleton-dependent nuclear positioning - inhibition of microtubule cytoskeleton-dependent nucleus positioning - inhibition of microtubule-dependent nuclear positioning - inhibition of microtubule-dependent nucleus positioning - inhibition of microtubule-mediated nuclear migration - inhibition of nuclear migration along microtubule - inhibition of nuclear migration, microtubule-mediated - inhibition of transport of nucleus by microtubules - inhibition of transport of nucleus, microtubule-mediated - biological_process - GO:1902839 - negative regulation of nuclear migration along microtubule - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule. - GOC:TermGenie - GO_REF:0000058 - PMID:23087209 - - - - - down regulation of microtubule cytoskeleton-dependent nuclear positioning - GOC:TermGenie - - - - - down regulation of microtubule cytoskeleton-dependent nucleus positioning - GOC:TermGenie - - - - - down regulation of microtubule-dependent nuclear positioning - GOC:TermGenie - - - - - down regulation of microtubule-dependent nucleus positioning - GOC:TermGenie - - - - - down regulation of microtubule-mediated nuclear migration - GOC:TermGenie - - - - - down regulation of nuclear migration along microtubule - GOC:TermGenie - - - - - down regulation of nuclear migration, microtubule-mediated - GOC:TermGenie - - - - - down regulation of transport of nucleus by microtubules - GOC:TermGenie - - - - - down regulation of transport of nucleus, microtubule-mediated - GOC:TermGenie - - - - - down-regulation of microtubule cytoskeleton-dependent nuclear positioning - GOC:TermGenie - - - - - down-regulation of microtubule cytoskeleton-dependent nucleus positioning - GOC:TermGenie - - - - - down-regulation of microtubule-dependent nuclear positioning - GOC:TermGenie - - - - - down-regulation of microtubule-dependent nucleus positioning - GOC:TermGenie - - - - - down-regulation of microtubule-mediated nuclear migration - GOC:TermGenie - - - - - down-regulation of nuclear migration along microtubule - GOC:TermGenie - - - - - down-regulation of nuclear migration, microtubule-mediated - GOC:TermGenie - - - - - down-regulation of transport of nucleus by microtubules - GOC:TermGenie - - - - - down-regulation of transport of nucleus, microtubule-mediated - GOC:TermGenie - - - - - downregulation of microtubule cytoskeleton-dependent nuclear positioning - GOC:TermGenie - - - - - downregulation of microtubule cytoskeleton-dependent nucleus positioning - GOC:TermGenie - - - - - downregulation of microtubule-dependent nuclear positioning - GOC:TermGenie - - - - - downregulation of microtubule-dependent nucleus positioning - GOC:TermGenie - - - - - downregulation of microtubule-mediated nuclear migration - GOC:TermGenie - - - - - downregulation of nuclear migration along microtubule - GOC:TermGenie - - - - - downregulation of nuclear migration, microtubule-mediated - GOC:TermGenie - - - - - downregulation of transport of nucleus by microtubules - GOC:TermGenie - - - - - downregulation of transport of nucleus, microtubule-mediated - GOC:TermGenie - - - - - negative regulation of microtubule cytoskeleton-dependent nuclear positioning - GOC:TermGenie - - - - - negative regulation of microtubule cytoskeleton-dependent nucleus positioning - GOC:TermGenie - - - - - negative regulation of microtubule-dependent nuclear positioning - GOC:TermGenie - - - - - negative regulation of microtubule-dependent nucleus positioning - GOC:TermGenie - - - - - negative regulation of microtubule-mediated nuclear migration - GOC:TermGenie - - - - - negative regulation of nuclear migration, microtubule-mediated - GOC:TermGenie - - - - - negative regulation of transport of nucleus by microtubules - GOC:TermGenie - - - - - negative regulation of transport of nucleus, microtubule-mediated - GOC:TermGenie - - - - - inhibition of microtubule cytoskeleton-dependent nuclear positioning - GOC:TermGenie - - - - - inhibition of microtubule cytoskeleton-dependent nucleus positioning - GOC:TermGenie - - - - - inhibition of microtubule-dependent nuclear positioning - GOC:TermGenie - - - - - inhibition of microtubule-dependent nucleus positioning - GOC:TermGenie - - - - - inhibition of microtubule-mediated nuclear migration - GOC:TermGenie - - - - - inhibition of nuclear migration along microtubule - GOC:TermGenie - - - - - inhibition of nuclear migration, microtubule-mediated - GOC:TermGenie - - - - - inhibition of transport of nucleus by microtubules - GOC:TermGenie - - - - - inhibition of transport of nucleus, microtubule-mediated - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule. - vw - 2014-04-01T13:50:35Z - positive regulation of microtubule cytoskeleton-dependent nuclear positioning - positive regulation of microtubule cytoskeleton-dependent nucleus positioning - positive regulation of microtubule-dependent nuclear positioning - positive regulation of microtubule-dependent nucleus positioning - positive regulation of microtubule-mediated nuclear migration - positive regulation of nuclear migration, microtubule-mediated - positive regulation of transport of nucleus by microtubules - positive regulation of transport of nucleus, microtubule-mediated - up regulation of microtubule cytoskeleton-dependent nuclear positioning - up regulation of microtubule cytoskeleton-dependent nucleus positioning - up regulation of microtubule-dependent nuclear positioning - up regulation of microtubule-dependent nucleus positioning - up regulation of microtubule-mediated nuclear migration - up regulation of nuclear migration along microtubule - up regulation of nuclear migration, microtubule-mediated - up regulation of transport of nucleus by microtubules - up regulation of transport of nucleus, microtubule-mediated - up-regulation of microtubule cytoskeleton-dependent nuclear positioning - up-regulation of microtubule cytoskeleton-dependent nucleus positioning - up-regulation of microtubule-dependent nuclear positioning - up-regulation of microtubule-dependent nucleus positioning - up-regulation of microtubule-mediated nuclear migration - up-regulation of nuclear migration along microtubule - up-regulation of nuclear migration, microtubule-mediated - up-regulation of transport of nucleus by microtubules - up-regulation of transport of nucleus, microtubule-mediated - upregulation of microtubule cytoskeleton-dependent nuclear positioning - upregulation of microtubule cytoskeleton-dependent nucleus positioning - upregulation of microtubule-dependent nuclear positioning - upregulation of microtubule-dependent nucleus positioning - upregulation of microtubule-mediated nuclear migration - upregulation of nuclear migration along microtubule - upregulation of nuclear migration, microtubule-mediated - upregulation of transport of nucleus by microtubules - upregulation of transport of nucleus, microtubule-mediated - activation of microtubule cytoskeleton-dependent nuclear positioning - activation of microtubule cytoskeleton-dependent nucleus positioning - activation of microtubule-dependent nuclear positioning - activation of microtubule-dependent nucleus positioning - activation of microtubule-mediated nuclear migration - activation of nuclear migration along microtubule - activation of nuclear migration, microtubule-mediated - activation of transport of nucleus by microtubules - activation of transport of nucleus, microtubule-mediated - biological_process - GO:1902840 - positive regulation of nuclear migration along microtubule - - - - - Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule. - GOC:TermGenie - GO_REF:0000058 - PMID:23087209 - - - - - positive regulation of microtubule cytoskeleton-dependent nuclear positioning - GOC:TermGenie - - - - - positive regulation of microtubule cytoskeleton-dependent nucleus positioning - GOC:TermGenie - - - - - positive regulation of microtubule-dependent nuclear positioning - GOC:TermGenie - - - - - positive regulation of microtubule-dependent nucleus positioning - GOC:TermGenie - - - - - positive regulation of microtubule-mediated nuclear migration - GOC:TermGenie - - - - - positive regulation of nuclear migration, microtubule-mediated - GOC:TermGenie - - - - - positive regulation of transport of nucleus by microtubules - GOC:TermGenie - - - - - positive regulation of transport of nucleus, microtubule-mediated - GOC:TermGenie - - - - - up regulation of microtubule cytoskeleton-dependent nuclear positioning - GOC:TermGenie - - - - - up regulation of microtubule cytoskeleton-dependent nucleus positioning - GOC:TermGenie - - - - - up regulation of microtubule-dependent nuclear positioning - GOC:TermGenie - - - - - up regulation of microtubule-dependent nucleus positioning - GOC:TermGenie - - - - - up regulation of microtubule-mediated nuclear migration - GOC:TermGenie - - - - - up regulation of nuclear migration along microtubule - GOC:TermGenie - - - - - up regulation of nuclear migration, microtubule-mediated - GOC:TermGenie - - - - - up regulation of transport of nucleus by microtubules - GOC:TermGenie - - - - - up regulation of transport of nucleus, microtubule-mediated - GOC:TermGenie - - - - - up-regulation of microtubule cytoskeleton-dependent nuclear positioning - GOC:TermGenie - - - - - up-regulation of microtubule cytoskeleton-dependent nucleus positioning - GOC:TermGenie - - - - - up-regulation of microtubule-dependent nuclear positioning - GOC:TermGenie - - - - - up-regulation of microtubule-dependent nucleus positioning - GOC:TermGenie - - - - - up-regulation of microtubule-mediated nuclear migration - GOC:TermGenie - - - - - up-regulation of nuclear migration along microtubule - GOC:TermGenie - - - - - up-regulation of nuclear migration, microtubule-mediated - GOC:TermGenie - - - - - up-regulation of transport of nucleus by microtubules - GOC:TermGenie - - - - - up-regulation of transport of nucleus, microtubule-mediated - GOC:TermGenie - - - - - upregulation of microtubule cytoskeleton-dependent nuclear positioning - GOC:TermGenie - - - - - upregulation of microtubule cytoskeleton-dependent nucleus positioning - GOC:TermGenie - - - - - upregulation of microtubule-dependent nuclear positioning - GOC:TermGenie - - - - - upregulation of microtubule-dependent nucleus positioning - GOC:TermGenie - - - - - upregulation of microtubule-mediated nuclear migration - GOC:TermGenie - - - - - upregulation of nuclear migration along microtubule - GOC:TermGenie - - - - - upregulation of nuclear migration, microtubule-mediated - GOC:TermGenie - - - - - upregulation of transport of nucleus by microtubules - GOC:TermGenie - - - - - upregulation of transport of nucleus, microtubule-mediated - GOC:TermGenie - - - - - activation of microtubule cytoskeleton-dependent nuclear positioning - GOC:TermGenie - - - - - activation of microtubule cytoskeleton-dependent nucleus positioning - GOC:TermGenie - - - - - activation of microtubule-dependent nuclear positioning - GOC:TermGenie - - - - - activation of microtubule-dependent nucleus positioning - GOC:TermGenie - - - - - activation of microtubule-mediated nuclear migration - GOC:TermGenie - - - - - activation of nuclear migration along microtubule - GOC:TermGenie - - - - - activation of nuclear migration, microtubule-mediated - GOC:TermGenie - - - - - activation of transport of nucleus by microtubules - GOC:TermGenie - - - - - activation of transport of nucleus, microtubule-mediated - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any microtubule cytoskeleton organization that is involved in mitosis. - vw - 2014-04-02T14:19:38Z - microtubule cytoskeleton organisation involved in mitosis - microtubule dynamics involved in mitosis - biological_process - microtubule cytoskeleton organization and biogenesis involved in mitosis - GO:1902850 - microtubule cytoskeleton organization involved in mitosis - - - - - Any microtubule cytoskeleton organization that is involved in mitosis. - GOC:TermGenie - GO_REF:0000060 - PMID:18799626 - - - - - microtubule cytoskeleton organisation involved in mitosis - GOC:TermGenie - - - - - microtubule dynamics involved in mitosis - GOC:TermGenie - - - - - microtubule cytoskeleton organization and biogenesis involved in mitosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of embryonic camera-type eye development. - mr - 2014-04-03T15:24:00Z - regulation of embryonic eye development - biological_process - GO:1902863 - regulation of embryonic camera-type eye development - - - - - Any process that modulates the frequency, rate or extent of embryonic camera-type eye development. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:16872597 - - - - - regulation of embryonic eye development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development. - mr - 2014-04-03T15:24:06Z - down regulation of embryonic camera-type eye development - down regulation of embryonic eye development - down-regulation of embryonic camera-type eye development - down-regulation of embryonic eye development - downregulation of embryonic camera-type eye development - downregulation of embryonic eye development - negative regulation of embryonic eye development - inhibition of embryonic camera-type eye development - inhibition of embryonic eye development - biological_process - GO:1902864 - negative regulation of embryonic camera-type eye development - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:16872597 - - - - - down regulation of embryonic camera-type eye development - GOC:TermGenie - - - - - down regulation of embryonic eye development - GOC:TermGenie - - - - - down-regulation of embryonic camera-type eye development - GOC:TermGenie - - - - - down-regulation of embryonic eye development - GOC:TermGenie - - - - - downregulation of embryonic camera-type eye development - GOC:TermGenie - - - - - downregulation of embryonic eye development - GOC:TermGenie - - - - - negative regulation of embryonic eye development - GOC:TermGenie - - - - - inhibition of embryonic camera-type eye development - GOC:TermGenie - - - - - inhibition of embryonic eye development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development. - mr - 2014-04-03T15:24:12Z - positive regulation of embryonic eye development - up regulation of embryonic camera-type eye development - up regulation of embryonic eye development - up-regulation of embryonic camera-type eye development - up-regulation of embryonic eye development - upregulation of embryonic camera-type eye development - upregulation of embryonic eye development - activation of embryonic camera-type eye development - activation of embryonic eye development - biological_process - GO:1902865 - positive regulation of embryonic camera-type eye development - - - - - Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:16872597 - - - - - positive regulation of embryonic eye development - GOC:TermGenie - - - - - up regulation of embryonic camera-type eye development - GOC:TermGenie - - - - - up regulation of embryonic eye development - GOC:TermGenie - - - - - up-regulation of embryonic camera-type eye development - GOC:TermGenie - - - - - up-regulation of embryonic eye development - GOC:TermGenie - - - - - upregulation of embryonic camera-type eye development - GOC:TermGenie - - - - - upregulation of embryonic eye development - GOC:TermGenie - - - - - activation of embryonic camera-type eye development - GOC:TermGenie - - - - - activation of embryonic eye development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of retina development in camera-type eye. - mr - 2014-04-03T15:24:17Z - regulation of retina development in camera-style eye - biological_process - regulation of retinal development - GO:1902866 - regulation of retina development in camera-type eye - - - - - Any process that modulates the frequency, rate or extent of retina development in camera-type eye. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:16872597 - - - - - regulation of retina development in camera-style eye - GOC:TermGenie - - - - - regulation of retinal development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye. - mr - 2014-04-03T15:24:23Z - down regulation of retina development in camera-style eye - down regulation of retina development in camera-type eye - down-regulation of retina development in camera-style eye - down-regulation of retina development in camera-type eye - downregulation of retina development in camera-style eye - downregulation of retina development in camera-type eye - negative regulation of retina development in camera-style eye - inhibition of retina development in camera-style eye - inhibition of retina development in camera-type eye - biological_process - down regulation of retinal development - down-regulation of retinal development - downregulation of retinal development - inhibition of retinal development - negative regulation of retinal development - GO:1902867 - negative regulation of retina development in camera-type eye - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:16872597 - - - - - down regulation of retina development in camera-style eye - GOC:TermGenie - - - - - down regulation of retina development in camera-type eye - GOC:TermGenie - - - - - down-regulation of retina development in camera-style eye - GOC:TermGenie - - - - - down-regulation of retina development in camera-type eye - GOC:TermGenie - - - - - downregulation of retina development in camera-style eye - GOC:TermGenie - - - - - downregulation of retina development in camera-type eye - GOC:TermGenie - - - - - negative regulation of retina development in camera-style eye - GOC:TermGenie - - - - - inhibition of retina development in camera-style eye - GOC:TermGenie - - - - - inhibition of retina development in camera-type eye - GOC:TermGenie - - - - - down regulation of retinal development - GOC:TermGenie - - - - - down-regulation of retinal development - GOC:TermGenie - - - - - downregulation of retinal development - GOC:TermGenie - - - - - inhibition of retinal development - GOC:TermGenie - - - - - negative regulation of retinal development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye. - mr - 2014-04-03T15:24:29Z - positive regulation of retina development in camera-style eye - up regulation of retina development in camera-style eye - up regulation of retina development in camera-type eye - up-regulation of retina development in camera-style eye - up-regulation of retina development in camera-type eye - upregulation of retina development in camera-style eye - upregulation of retina development in camera-type eye - activation of retina development in camera-style eye - activation of retina development in camera-type eye - biological_process - activation of retinal development - positive regulation of retinal development - up regulation of retinal development - up-regulation of retinal development - upregulation of retinal development - GO:1902868 - positive regulation of retina development in camera-type eye - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:16872597 - - - - - positive regulation of retina development in camera-style eye - GOC:TermGenie - - - - - up regulation of retina development in camera-style eye - GOC:TermGenie - - - - - up regulation of retina development in camera-type eye - GOC:TermGenie - - - - - up-regulation of retina development in camera-style eye - GOC:TermGenie - - - - - up-regulation of retina development in camera-type eye - GOC:TermGenie - - - - - upregulation of retina development in camera-style eye - GOC:TermGenie - - - - - upregulation of retina development in camera-type eye - GOC:TermGenie - - - - - activation of retina development in camera-style eye - GOC:TermGenie - - - - - activation of retina development in camera-type eye - GOC:TermGenie - - - - - activation of retinal development - GOC:TermGenie - - - - - positive regulation of retinal development - GOC:TermGenie - - - - - up regulation of retinal development - GOC:TermGenie - - - - - up-regulation of retinal development - GOC:TermGenie - - - - - upregulation of retinal development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of supramolecular fiber organization. - rl - 2014-04-15T16:46:36Z - biological_process - regulation of fibril organisation - GO:1902903 - HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro - regulation of supramolecular fiber organization - - - - - Any process that modulates the frequency, rate or extent of supramolecular fiber organization. - GOC:PARL - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:23921388 - - - - - regulation of fibril organisation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization. - rl - 2014-04-15T16:46:42Z - inhibition of fibril organisation - inhibition of fibril organization - biological_process - down regulation of fibril organisation - down regulation of fibril organization - down-regulation of fibril organisation - down-regulation of fibril organization - downregulation of fibril organisation - downregulation of fibril organization - negative regulation of fibril organisation - GO:1902904 - HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro - negative regulation of supramolecular fiber organization - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization. - GOC:PARL - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:23921388 - - - - - inhibition of fibril organisation - GOC:TermGenie - - - - - inhibition of fibril organization - GOC:TermGenie - - - - - down regulation of fibril organisation - GOC:TermGenie - - - - - down regulation of fibril organization - GOC:TermGenie - - - - - down-regulation of fibril organisation - GOC:TermGenie - - - - - down-regulation of fibril organization - GOC:TermGenie - - - - - downregulation of fibril organisation - GOC:TermGenie - - - - - downregulation of fibril organization - GOC:TermGenie - - - - - negative regulation of fibril organisation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization. - rl - 2014-04-15T16:46:48Z - activation of fibril organisation - activation of fibril organization - biological_process - positive regulation of fibril organisation - up regulation of fibril organisation - up regulation of fibril organization - up-regulation of fibril organisation - up-regulation of fibril organization - upregulation of fibril organisation - upregulation of fibril organization - GO:1902905 - HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro - positive regulation of supramolecular fiber organization - - - - - Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization. - GOC:PARL - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:23921388 - - - - - activation of fibril organisation - GOC:TermGenie - - - - - activation of fibril organization - GOC:TermGenie - - - - - positive regulation of fibril organisation - GOC:TermGenie - - - - - up regulation of fibril organisation - GOC:TermGenie - - - - - up regulation of fibril organization - GOC:TermGenie - - - - - up-regulation of fibril organisation - GOC:TermGenie - - - - - up-regulation of fibril organization - GOC:TermGenie - - - - - upregulation of fibril organisation - GOC:TermGenie - - - - - upregulation of fibril organization - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation. - mr - 2014-04-18T21:06:42Z - up regulation of neuroepithelial cell differentiation - up-regulation of neuroepithelial cell differentiation - upregulation of neuroepithelial cell differentiation - activation of neuroepithelial cell differentiation - biological_process - GO:1902913 - positive regulation of neuroepithelial cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:16916506 - - - - - up regulation of neuroepithelial cell differentiation - GOC:TermGenie - - - - - up-regulation of neuroepithelial cell differentiation - GOC:TermGenie - - - - - upregulation of neuroepithelial cell differentiation - GOC:TermGenie - - - - - activation of neuroepithelial cell differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The disaggregation of an organelle into its constituent components. - jl - 2014-05-13T12:36:03Z - organelle degradation - biological_process - GO:1903008 - organelle disassembly - - - - - The disaggregation of an organelle into its constituent components. - GOC:TermGenie - GO_REF:0000079 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of bone development. - mr - 2014-05-13T22:41:53Z - biological_process - GO:1903010 - regulation of bone development - - - - - Any process that modulates the frequency, rate or extent of bone development. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:22510437 - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of bone development. - mr - 2014-05-13T22:42:00Z - down regulation of bone development - down-regulation of bone development - downregulation of bone development - inhibition of bone development - biological_process - GO:1903011 - negative regulation of bone development - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of bone development. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:22510437 - - - - - down regulation of bone development - GOC:TermGenie - - - - - down-regulation of bone development - GOC:TermGenie - - - - - downregulation of bone development - GOC:TermGenie - - - - - inhibition of bone development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of bone development. - mr - 2014-05-13T22:42:06Z - up regulation of bone development - up-regulation of bone development - upregulation of bone development - activation of bone development - biological_process - GO:1903012 - positive regulation of bone development - - - - - Any process that activates or increases the frequency, rate or extent of bone development. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:22510437 - - - - - up regulation of bone development - GOC:TermGenie - - - - - up-regulation of bone development - GOC:TermGenie - - - - - upregulation of bone development - GOC:TermGenie - - - - - activation of bone development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of glycoprotein metabolic process. - rl - 2014-05-14T18:44:19Z - regulation of glycoprotein metabolism - biological_process - GO:1903018 - human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein - regulation of glycoprotein metabolic process - - - - - Any process that modulates the frequency, rate or extent of glycoprotein metabolic process. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:23544079 - - - - - regulation of glycoprotein metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process. - rl - 2014-05-14T18:44:25Z - down regulation of glycoprotein metabolic process - down regulation of glycoprotein metabolism - down-regulation of glycoprotein metabolic process - down-regulation of glycoprotein metabolism - downregulation of glycoprotein metabolic process - downregulation of glycoprotein metabolism - negative regulation of glycoprotein metabolism - inhibition of glycoprotein metabolic process - inhibition of glycoprotein metabolism - biological_process - GO:1903019 - human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein - negative regulation of glycoprotein metabolic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:23544079 - - - - - down regulation of glycoprotein metabolic process - GOC:TermGenie - - - - - down regulation of glycoprotein metabolism - GOC:TermGenie - - - - - down-regulation of glycoprotein metabolic process - GOC:TermGenie - - - - - down-regulation of glycoprotein metabolism - GOC:TermGenie - - - - - downregulation of glycoprotein metabolic process - GOC:TermGenie - - - - - downregulation of glycoprotein metabolism - GOC:TermGenie - - - - - negative regulation of glycoprotein metabolism - GOC:TermGenie - - - - - inhibition of glycoprotein metabolic process - GOC:TermGenie - - - - - inhibition of glycoprotein metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process. - rl - 2014-05-14T18:44:31Z - positive regulation of glycoprotein metabolism - up regulation of glycoprotein metabolic process - up regulation of glycoprotein metabolism - up-regulation of glycoprotein metabolic process - up-regulation of glycoprotein metabolism - upregulation of glycoprotein metabolic process - upregulation of glycoprotein metabolism - activation of glycoprotein metabolic process - activation of glycoprotein metabolism - biological_process - GO:1903020 - human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein - positive regulation of glycoprotein metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:23544079 - - - - - positive regulation of glycoprotein metabolism - GOC:TermGenie - - - - - up regulation of glycoprotein metabolic process - GOC:TermGenie - - - - - up regulation of glycoprotein metabolism - GOC:TermGenie - - - - - up-regulation of glycoprotein metabolic process - GOC:TermGenie - - - - - up-regulation of glycoprotein metabolism - GOC:TermGenie - - - - - upregulation of glycoprotein metabolic process - GOC:TermGenie - - - - - upregulation of glycoprotein metabolism - GOC:TermGenie - - - - - activation of glycoprotein metabolic process - GOC:TermGenie - - - - - activation of glycoprotein metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is part of the meiotic cell cycle. - jl - 2014-05-22T14:22:28Z - biological_process - GO:1903046 - - - meiotic cell cycle process - - - - - A process that is part of the meiotic cell cycle. - GOC:TermGenie - GOC:mtg_cell_cycle - GO_REF:0000060 - - - - - - - - - - - - - - - - - - - - - - - - - - A process that is part of the mitotic cell cycle. - jl - 2014-05-22T14:22:34Z - biological_process - GO:1903047 - - mitotic cell cycle process - - - - - A process that is part of the mitotic cell cycle. - GOC:TermGenie - GOC:mtg_cell_cycle - GO_REF:0000060 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of extracellular matrix organization. - rl - 2014-05-23T17:15:41Z - regulation of extracellular matrix organisation - biological_process - regulation of extracellular matrix organization and biogenesis - GO:1903053 - regulation of extracellular matrix organization - - - - - Any process that modulates the frequency, rate or extent of extracellular matrix organization. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:22357537 - - - - - regulation of extracellular matrix organisation - GOC:TermGenie - - - - - regulation of extracellular matrix organization and biogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization. - rl - 2014-05-23T17:15:47Z - down regulation of extracellular matrix organisation - down regulation of extracellular matrix organization - down-regulation of extracellular matrix organisation - down-regulation of extracellular matrix organization - downregulation of extracellular matrix organisation - downregulation of extracellular matrix organization - negative regulation of extracellular matrix organisation - inhibition of extracellular matrix organisation - inhibition of extracellular matrix organization - biological_process - down regulation of extracellular matrix organization and biogenesis - down-regulation of extracellular matrix organization and biogenesis - downregulation of extracellular matrix organization and biogenesis - inhibition of extracellular matrix organization and biogenesis - negative regulation of extracellular matrix organization and biogenesis - GO:1903054 - negative regulation of extracellular matrix organization - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:22357537 - - - - - down regulation of extracellular matrix organisation - GOC:TermGenie - - - - - down regulation of extracellular matrix organization - GOC:TermGenie - - - - - down-regulation of extracellular matrix organisation - GOC:TermGenie - - - - - down-regulation of extracellular matrix organization - GOC:TermGenie - - - - - downregulation of extracellular matrix organisation - GOC:TermGenie - - - - - downregulation of extracellular matrix organization - GOC:TermGenie - - - - - negative regulation of extracellular matrix organisation - GOC:TermGenie - - - - - inhibition of extracellular matrix organisation - GOC:TermGenie - - - - - inhibition of extracellular matrix organization - GOC:TermGenie - - - - - down regulation of extracellular matrix organization and biogenesis - GOC:TermGenie - - - - - down-regulation of extracellular matrix organization and biogenesis - GOC:TermGenie - - - - - downregulation of extracellular matrix organization and biogenesis - GOC:TermGenie - - - - - inhibition of extracellular matrix organization and biogenesis - GOC:TermGenie - - - - - negative regulation of extracellular matrix organization and biogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. - rl - 2014-05-23T17:15:53Z - positive regulation of extracellular matrix organisation - up regulation of extracellular matrix organisation - up regulation of extracellular matrix organization - up-regulation of extracellular matrix organisation - up-regulation of extracellular matrix organization - upregulation of extracellular matrix organisation - upregulation of extracellular matrix organization - activation of extracellular matrix organisation - activation of extracellular matrix organization - biological_process - activation of extracellular matrix organization and biogenesis - positive regulation of extracellular matrix organization and biogenesis - up regulation of extracellular matrix organization and biogenesis - up-regulation of extracellular matrix organization and biogenesis - upregulation of extracellular matrix organization and biogenesis - GO:1903055 - positive regulation of extracellular matrix organization - - - - - Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:22357537 - - - - - positive regulation of extracellular matrix organisation - GOC:TermGenie - - - - - up regulation of extracellular matrix organisation - GOC:TermGenie - - - - - up regulation of extracellular matrix organization - GOC:TermGenie - - - - - up-regulation of extracellular matrix organisation - GOC:TermGenie - - - - - up-regulation of extracellular matrix organization - GOC:TermGenie - - - - - upregulation of extracellular matrix organisation - GOC:TermGenie - - - - - upregulation of extracellular matrix organization - GOC:TermGenie - - - - - activation of extracellular matrix organisation - GOC:TermGenie - - - - - activation of extracellular matrix organization - GOC:TermGenie - - - - - activation of extracellular matrix organization and biogenesis - GOC:TermGenie - - - - - positive regulation of extracellular matrix organization and biogenesis - GOC:TermGenie - - - - - up regulation of extracellular matrix organization and biogenesis - GOC:TermGenie - - - - - up-regulation of extracellular matrix organization and biogenesis - GOC:TermGenie - - - - - upregulation of extracellular matrix organization and biogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. - tb - 2009-07-10T10:32:44Z - GO:0090003 - GO:1905963 - regulation of protein localization in plasma membrane - biological_process - regulation of establishment of protein localisation in plasma membrane - regulation of establishment of protein localization in plasma membrane - regulation of establishment of protein localization to plasma membrane - regulation of protein localisation in plasma membrane - regulation of protein targeting to plasma membrane - regulation of protein-plasma membrane targeting - GO:1903076 - regulation of protein localization to plasma membrane - - - - - Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:11602640 - - - - - regulation of protein localization in plasma membrane - GOC:TermGenie - - - - - regulation of establishment of protein localisation in plasma membrane - GOC:mah - - - - - regulation of protein localisation in plasma membrane - GOC:TermGenie - - - - - regulation of protein-plasma membrane targeting - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. - tb - 2014-05-29T17:10:16Z - GO:0090005 - GO:1905964 - down regulation of protein localisation in plasma membrane - down regulation of protein localization in plasma membrane - down regulation of protein localization to plasma membrane - down-regulation of protein localisation in plasma membrane - down-regulation of protein localization in plasma membrane - down-regulation of protein localization to plasma membrane - downregulation of protein localisation in plasma membrane - downregulation of protein localization in plasma membrane - downregulation of protein localization to plasma membrane - negative regulation of protein localization in plasma membrane - inhibition of protein localisation in plasma membrane - inhibition of protein localization in plasma membrane - inhibition of protein localization to plasma membrane - inhibition of protein targeting to plasma membrane - inhibition of protein-plasma membrane targeting - biological_process - down regulation of protein targeting to plasma membrane - down regulation of protein-plasma membrane targeting - down-regulation of protein targeting to plasma membrane - down-regulation of protein-plasma membrane targeting - downregulation of protein targeting to plasma membrane - downregulation of protein-plasma membrane targeting - negative regulation of establishment of protein localisation in plasma membrane - negative regulation of establishment of protein localization in plasma membrane - negative regulation of establishment of protein localization to plasma membrane - negative regulation of protein localisation in plasma membrane - negative regulation of protein targeting to plasma membrane - negative regulation of protein-plasma membrane targeting - GO:1903077 - negative regulation of protein localization to plasma membrane - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:11602640 - - - - - down regulation of protein localisation in plasma membrane - GOC:TermGenie - - - - - down regulation of protein localization in plasma membrane - GOC:TermGenie - - - - - down regulation of protein localization to plasma membrane - GOC:TermGenie - - - - - down-regulation of protein localisation in plasma membrane - GOC:TermGenie - - - - - down-regulation of protein localization in plasma membrane - GOC:TermGenie - - - - - down-regulation of protein localization to plasma membrane - GOC:TermGenie - - - - - downregulation of protein localisation in plasma membrane - GOC:TermGenie - - - - - downregulation of protein localization in plasma membrane - GOC:TermGenie - - - - - downregulation of protein localization to plasma membrane - GOC:TermGenie - - - - - negative regulation of protein localization in plasma membrane - GOC:TermGenie - - - - - inhibition of protein localisation in plasma membrane - GOC:TermGenie - - - - - inhibition of protein localization in plasma membrane - GOC:TermGenie - - - - - inhibition of protein localization to plasma membrane - GOC:TermGenie - - - - - inhibition of protein targeting to plasma membrane - GOC:TermGenie - - - - - inhibition of protein-plasma membrane targeting - GOC:TermGenie - - - - - down regulation of protein targeting to plasma membrane - GOC:TermGenie - - - - - down regulation of protein-plasma membrane targeting - GOC:TermGenie - - - - - down-regulation of protein targeting to plasma membrane - GOC:TermGenie - - - - - down-regulation of protein-plasma membrane targeting - GOC:TermGenie - - - - - downregulation of protein targeting to plasma membrane - GOC:TermGenie - - - - - downregulation of protein-plasma membrane targeting - GOC:TermGenie - - - - - negative regulation of establishment of protein localisation in plasma membrane - GOC:mah - - - - - negative regulation of protein localisation in plasma membrane - GOC:TermGenie - - - - - negative regulation of protein-plasma membrane targeting - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. - tb - 2009-07-10T10:34:17Z - GO:0090004 - GO:1905965 - positive regulation of protein localisation in plasma membrane - positive regulation of protein localization in plasma membrane - up regulation of protein localisation in plasma membrane - up regulation of protein localization in plasma membrane - up regulation of protein localization to plasma membrane - up-regulation of protein localisation in plasma membrane - up-regulation of protein localization in plasma membrane - up-regulation of protein localization to plasma membrane - upregulation of protein localisation in plasma membrane - upregulation of protein localization in plasma membrane - upregulation of protein localization to plasma membrane - activation of protein localisation in plasma membrane - activation of protein localization in plasma membrane - activation of protein localization to plasma membrane - activation of protein targeting to plasma membrane - activation of protein-plasma membrane targeting - biological_process - positive regulation of establishment of protein localisation in plasma membrane - positive regulation of establishment of protein localization to plasma membrane - positive regulation of protein targeting to plasma membrane - positive regulation of protein-plasma membrane targeting - up regulation of protein targeting to plasma membrane - up regulation of protein-plasma membrane targeting - up-regulation of protein targeting to plasma membrane - up-regulation of protein-plasma membrane targeting - upregulation of protein targeting to plasma membrane - upregulation of protein-plasma membrane targeting - GO:1903078 - positive regulation of protein localization to plasma membrane - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:11602640 - - - - - positive regulation of protein localisation in plasma membrane - GOC:TermGenie - - - - - positive regulation of protein localization in plasma membrane - GOC:TermGenie - - - - - up regulation of protein localisation in plasma membrane - GOC:TermGenie - - - - - up regulation of protein localization in plasma membrane - GOC:TermGenie - - - - - up regulation of protein localization to plasma membrane - GOC:TermGenie - - - - - up-regulation of protein localisation in plasma membrane - GOC:TermGenie - - - - - up-regulation of protein localization in plasma membrane - GOC:TermGenie - - - - - up-regulation of protein localization to plasma membrane - GOC:TermGenie - - - - - upregulation of protein localisation in plasma membrane - GOC:TermGenie - - - - - upregulation of protein localization in plasma membrane - GOC:TermGenie - - - - - upregulation of protein localization to plasma membrane - GOC:TermGenie - - - - - activation of protein localisation in plasma membrane - GOC:TermGenie - - - - - activation of protein localization in plasma membrane - GOC:TermGenie - - - - - activation of protein localization to plasma membrane - GOC:TermGenie - - - - - activation of protein targeting to plasma membrane - GOC:TermGenie - - - - - activation of protein-plasma membrane targeting - GOC:TermGenie - - - - - positive regulation of establishment of protein localisation in plasma membrane - GOC:mah - - - - - positive regulation of protein-plasma membrane targeting - GOC:TermGenie - - - - - up regulation of protein targeting to plasma membrane - GOC:TermGenie - - - - - up regulation of protein-plasma membrane targeting - GOC:TermGenie - - - - - up-regulation of protein targeting to plasma membrane - GOC:TermGenie - - - - - up-regulation of protein-plasma membrane targeting - GOC:TermGenie - - - - - upregulation of protein targeting to plasma membrane - GOC:TermGenie - - - - - upregulation of protein-plasma membrane targeting - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of actin filament-based movement. - al - 2014-06-12T16:55:57Z - biological_process - GO:1903115 - regulation of actin filament-based movement - - - - - Any process that modulates the frequency, rate or extent of actin filament-based movement. - GOC:TermGenie - GO_REF:0000058 - PMID:24798735 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of actin filament-based movement. - al - 2014-06-12T16:56:04Z - up regulation of actin filament-based movement - up-regulation of actin filament-based movement - upregulation of actin filament-based movement - activation of actin filament-based movement - biological_process - GO:1903116 - positive regulation of actin filament-based movement - - - - - Any process that activates or increases the frequency, rate or extent of actin filament-based movement. - GOC:TermGenie - GO_REF:0000058 - PMID:24798735 - - - - - up regulation of actin filament-based movement - GOC:TermGenie - - - - - up-regulation of actin filament-based movement - GOC:TermGenie - - - - - upregulation of actin filament-based movement - GOC:TermGenie - - - - - activation of actin filament-based movement - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton. - mah - 2014-06-16T11:27:09Z - protein localisation in actin cytoskeleton - protein localisation to actin cytoskeleton - protein localization in actin cytoskeleton - biological_process - GO:1903119 - protein localization to actin cytoskeleton - - - - - A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton. - GOC:TermGenie - GO_REF:0000087 - PMID:24798735 - - - - - protein localisation in actin cytoskeleton - GOC:TermGenie - - - - - protein localisation to actin cytoskeleton - GOC:TermGenie - - - - - protein localization in actin cytoskeleton - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, the location of an actin filament bundle. - mah - 2014-06-16T11:27:16Z - protein localisation in actin filament bundle - protein localisation to actin filament bundle - protein localization in actin filament bundle - biological_process - protein localization to actin cable - GO:1903120 - protein localization to actin filament bundle - - - - - A process in which a protein is transported to, or maintained in, the location of an actin filament bundle. - GOC:TermGenie - GO_REF:0000087 - PMID:24798735 - - - - - protein localisation in actin filament bundle - GOC:TermGenie - - - - - protein localisation to actin filament bundle - GOC:TermGenie - - - - - protein localization in actin filament bundle - GOC:TermGenie - - - - - protein localization to actin cable - GOC:mah - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell. - cls - 2014-06-25T15:47:09Z - biological_process - GO:1903131 - mononuclear cell differentiation - - - - - The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell. - CL:0000842 - GOC:TermGenie - GO_REF:0000086 - PMID:24759906 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of endodermal cell differentiation. - als - 2014-07-29T13:22:35Z - regulation of endoderm cell differentiation - biological_process - GO:1903224 - regulation of endodermal cell differentiation - - - - - Any process that modulates the frequency, rate or extent of endodermal cell differentiation. - GOC:TermGenie - GOC:als - GO_REF:0000058 - PMID:23154389 - - - - - regulation of endoderm cell differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation. - als - 2014-07-29T13:22:41Z - down regulation of endoderm cell differentiation - down regulation of endodermal cell differentiation - down-regulation of endoderm cell differentiation - down-regulation of endodermal cell differentiation - downregulation of endoderm cell differentiation - downregulation of endodermal cell differentiation - negative regulation of endoderm cell differentiation - inhibition of endoderm cell differentiation - inhibition of endodermal cell differentiation - biological_process - GO:1903225 - negative regulation of endodermal cell differentiation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation. - GOC:TermGenie - GOC:als - GO_REF:0000058 - PMID:23154389 - - - - - down regulation of endoderm cell differentiation - GOC:TermGenie - - - - - down regulation of endodermal cell differentiation - GOC:TermGenie - - - - - down-regulation of endoderm cell differentiation - GOC:TermGenie - - - - - down-regulation of endodermal cell differentiation - GOC:TermGenie - - - - - downregulation of endoderm cell differentiation - GOC:TermGenie - - - - - downregulation of endodermal cell differentiation - GOC:TermGenie - - - - - negative regulation of endoderm cell differentiation - GOC:TermGenie - - - - - inhibition of endoderm cell differentiation - GOC:TermGenie - - - - - inhibition of endodermal cell differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation. - als - 2014-07-29T13:22:47Z - positive regulation of endoderm cell differentiation - up regulation of endoderm cell differentiation - up regulation of endodermal cell differentiation - up-regulation of endoderm cell differentiation - up-regulation of endodermal cell differentiation - upregulation of endoderm cell differentiation - upregulation of endodermal cell differentiation - activation of endoderm cell differentiation - activation of endodermal cell differentiation - biological_process - GO:1903226 - positive regulation of endodermal cell differentiation - - - - - Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation. - GOC:TermGenie - GOC:als - GO_REF:0000058 - PMID:23154389 - - - - - positive regulation of endoderm cell differentiation - GOC:TermGenie - - - - - up regulation of endoderm cell differentiation - GOC:TermGenie - - - - - up regulation of endodermal cell differentiation - GOC:TermGenie - - - - - up-regulation of endoderm cell differentiation - GOC:TermGenie - - - - - up-regulation of endodermal cell differentiation - GOC:TermGenie - - - - - upregulation of endoderm cell differentiation - GOC:TermGenie - - - - - upregulation of endodermal cell differentiation - GOC:TermGenie - - - - - activation of endoderm cell differentiation - GOC:TermGenie - - - - - activation of endodermal cell differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, a location within a Golgi membrane. - mah - 2014-08-12T14:22:31Z - protein localisation in Golgi membrane - protein localisation to Golgi membrane - protein localization in Golgi membrane - biological_process - GO:1903292 - protein localization to Golgi membrane - - - - - A process in which a protein is transported to, or maintained in, a location within a Golgi membrane. - GOC:TermGenie - GO_REF:0000087 - PMID:11378902 - - - - - protein localisation in Golgi membrane - GOC:TermGenie - - - - - protein localisation to Golgi membrane - GOC:TermGenie - - - - - protein localization in Golgi membrane - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of vacuolar transport. - vw - 2014-08-18T13:16:04Z - biological_process - GO:1903335 - regulation of vacuolar transport - - - - - Any process that modulates the frequency, rate or extent of vacuolar transport. - GOC:TermGenie - GOC:vw - GO_REF:0000058 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport. - vw - 2014-08-18T13:16:11Z - down regulation of vacuolar transport - down-regulation of vacuolar transport - downregulation of vacuolar transport - inhibition of vacuolar transport - biological_process - GO:1903336 - negative regulation of vacuolar transport - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport. - GOC:TermGenie - GOC:vw - GO_REF:0000058 - - - - - down regulation of vacuolar transport - GOC:TermGenie - - - - - down-regulation of vacuolar transport - GOC:TermGenie - - - - - downregulation of vacuolar transport - GOC:TermGenie - - - - - inhibition of vacuolar transport - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of vacuolar transport. - vw - 2014-08-18T13:16:19Z - up regulation of vacuolar transport - up-regulation of vacuolar transport - upregulation of vacuolar transport - activation of vacuolar transport - biological_process - GO:1903337 - positive regulation of vacuolar transport - - - - - Any process that activates or increases the frequency, rate or extent of vacuolar transport. - GOC:TermGenie - GOC:vw - GO_REF:0000058 - - - - - up regulation of vacuolar transport - GOC:TermGenie - - - - - up-regulation of vacuolar transport - GOC:TermGenie - - - - - upregulation of vacuolar transport - GOC:TermGenie - - - - - activation of vacuolar transport - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of nucleus organization. - hjd - 2014-08-20T19:36:16Z - regulation of nuclear organisation - regulation of nuclear organization - biological_process - regulation of nuclear morphology - regulation of nuclear organization and biogenesis - regulation of nucleus organization and biogenesis - GO:1903353 - regulation of nucleus organization - - - - - Any process that modulates the frequency, rate or extent of nucleus organization. - GOC:TermGenie - GO_REF:0000058 - PMID:16943282 - - - - - regulation of nuclear organisation - GOC:TermGenie - - - - - regulation of nuclear organization - GOC:TermGenie - - - - - regulation of nuclear morphology - GOC:TermGenie - - - - - regulation of nuclear organization and biogenesis - GOC:TermGenie - - - - - regulation of nucleus organization and biogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of Golgi organization. - als - 2014-08-21T10:22:22Z - regulation of Golgi organisation - biological_process - regulation of Golgi organization and biogenesis - GO:1903358 - regulation of Golgi organization - - - - - Any process that modulates the frequency, rate or extent of Golgi organization. - GOC:TermGenie - GOC:als - GO_REF:0000058 - PMID:17562788 - - - - - regulation of Golgi organisation - GOC:TermGenie - - - - - regulation of Golgi organization and biogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of mitotic chromosome condensation. - al - 2014-08-26T13:57:13Z - biological_process - GO:1903379 - regulation of mitotic chromosome condensation - - - - - Any process that modulates the frequency, rate or extent of mitotic chromosome condensation. - GOC:TermGenie - GO_REF:0000058 - PMID:9490640 - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation. - al - 2014-08-26T13:57:29Z - up regulation of mitotic chromosome condensation - up-regulation of mitotic chromosome condensation - upregulation of mitotic chromosome condensation - activation of mitotic chromosome condensation - biological_process - GO:1903380 - positive regulation of mitotic chromosome condensation - - - - - Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation. - GOC:TermGenie - GO_REF:0000058 - PMID:9490640 - - - - - up regulation of mitotic chromosome condensation - GOC:TermGenie - - - - - up-regulation of mitotic chromosome condensation - GOC:TermGenie - - - - - upregulation of mitotic chromosome condensation - GOC:TermGenie - - - - - activation of mitotic chromosome condensation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. - rl - 2014-09-03T12:45:43Z - biological_process - GO:1903412 - response to bile acid - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000071 - PMID:21757002 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cell maturation. - jl - 2014-09-15T13:31:23Z - biological_process - regulation of functional differentiation - GO:1903429 - regulation of cell maturation - - - - - Any process that modulates the frequency, rate or extent of cell maturation. - GOC:TermGenie - GO_REF:0000058 - PMID:17459944 - - - - - regulation of functional differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation. - jl - 2014-09-15T13:31:32Z - down regulation of cell maturation - down-regulation of cell maturation - downregulation of cell maturation - inhibition of cell maturation - biological_process - down regulation of functional differentiation - down-regulation of functional differentiation - downregulation of functional differentiation - inhibition of functional differentiation - negative regulation of functional differentiation - GO:1903430 - negative regulation of cell maturation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation. - GOC:TermGenie - GO_REF:0000058 - PMID:17459944 - - - - - down regulation of cell maturation - GOC:TermGenie - - - - - down-regulation of cell maturation - GOC:TermGenie - - - - - downregulation of cell maturation - GOC:TermGenie - - - - - inhibition of cell maturation - GOC:TermGenie - - - - - down regulation of functional differentiation - GOC:TermGenie - - - - - down-regulation of functional differentiation - GOC:TermGenie - - - - - downregulation of functional differentiation - GOC:TermGenie - - - - - inhibition of functional differentiation - GOC:TermGenie - - - - - negative regulation of functional differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cell maturation. - jl - 2014-09-15T13:31:41Z - up regulation of cell maturation - up-regulation of cell maturation - upregulation of cell maturation - activation of cell maturation - biological_process - activation of functional differentiation - positive regulation of functional differentiation - up regulation of functional differentiation - up-regulation of functional differentiation - upregulation of functional differentiation - GO:1903431 - positive regulation of cell maturation - - - - - Any process that activates or increases the frequency, rate or extent of cell maturation. - GOC:TermGenie - GO_REF:0000058 - PMID:17459944 - - - - - up regulation of cell maturation - GOC:TermGenie - - - - - up-regulation of cell maturation - GOC:TermGenie - - - - - upregulation of cell maturation - GOC:TermGenie - - - - - activation of cell maturation - GOC:TermGenie - - - - - activation of functional differentiation - GOC:TermGenie - - - - - positive regulation of functional differentiation - GOC:TermGenie - - - - - up regulation of functional differentiation - GOC:TermGenie - - - - - up-regulation of functional differentiation - GOC:TermGenie - - - - - upregulation of functional differentiation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, a location within a ciliary membrane. - pr - 2014-09-16T15:15:39Z - protein localisation in ciliary membrane - protein localisation to ciliary membrane - protein localization in ciliary membrane - biological_process - GO:1903441 - protein localization to ciliary membrane - - - - - A process in which a protein is transported to, or maintained in, a location within a ciliary membrane. - GOC:TermGenie - GOC:cilia - GOC:krc - GO_REF:0000087 - PMID:22139371 - - - - - protein localisation in ciliary membrane - GOC:TermGenie - - - - - protein localisation to ciliary membrane - GOC:TermGenie - - - - - protein localization in ciliary membrane - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving mucopolysaccharide. - dph - 2014-10-01T21:55:47Z - mucopolysaccharide metabolism - biological_process - GO:1903510 - mucopolysaccharide metabolic process - - - - - The chemical reactions and pathways involving mucopolysaccharide. - GOC:TermGenie - GOC:dph - GO_REF:0000068 - PMID:4236091 - - - - - mucopolysaccharide metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of blood circulation. - mr - 2014-10-06T18:38:56Z - biological_process - regulation of hemolymph circulation - GO:1903522 - regulation of blood circulation - - - - - Any process that modulates the frequency, rate or extent of blood circulation. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:10659969 - - - - - regulation of hemolymph circulation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. - mr - 2014-10-06T18:39:05Z - down regulation of blood circulation - down-regulation of blood circulation - downregulation of blood circulation - inhibition of blood circulation - biological_process - down regulation of hemolymph circulation - down-regulation of hemolymph circulation - downregulation of hemolymph circulation - inhibition of hemolymph circulation - negative regulation of hemolymph circulation - GO:1903523 - negative regulation of blood circulation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:10659969 - - - - - down regulation of blood circulation - GOC:TermGenie - - - - - down-regulation of blood circulation - GOC:TermGenie - - - - - downregulation of blood circulation - GOC:TermGenie - - - - - inhibition of blood circulation - GOC:TermGenie - - - - - down regulation of hemolymph circulation - GOC:TermGenie - - - - - down-regulation of hemolymph circulation - GOC:TermGenie - - - - - downregulation of hemolymph circulation - GOC:TermGenie - - - - - inhibition of hemolymph circulation - GOC:TermGenie - - - - - negative regulation of hemolymph circulation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of blood circulation. - mr - 2014-10-06T18:39:13Z - up regulation of blood circulation - up-regulation of blood circulation - upregulation of blood circulation - activation of blood circulation - biological_process - activation of hemolymph circulation - positive regulation of hemolymph circulation - up regulation of hemolymph circulation - up-regulation of hemolymph circulation - upregulation of hemolymph circulation - GO:1903524 - positive regulation of blood circulation - - - - - Any process that activates or increases the frequency, rate or extent of blood circulation. - GOC:TermGenie - GOC:mr - GO_REF:0000058 - PMID:10659969 - - - - - up regulation of blood circulation - GOC:TermGenie - - - - - up-regulation of blood circulation - GOC:TermGenie - - - - - upregulation of blood circulation - GOC:TermGenie - - - - - activation of blood circulation - GOC:TermGenie - - - - - activation of hemolymph circulation - GOC:TermGenie - - - - - positive regulation of hemolymph circulation - GOC:TermGenie - - - - - up regulation of hemolymph circulation - GOC:TermGenie - - - - - up-regulation of hemolymph circulation - GOC:TermGenie - - - - - upregulation of hemolymph circulation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of secretion by cell. - pm - 2014-10-08T13:24:59Z - regulation of cellular secretion - biological_process - GO:1903530 - regulation of secretion by cell - - - - - Any process that modulates the frequency, rate or extent of secretion by cell. - GOC:TermGenie - GOC:pm - GO_REF:0000058 - PMID:12130530 - - - - - regulation of cellular secretion - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell. - pm - 2014-10-08T13:25:08Z - down regulation of cellular secretion - down regulation of secretion by cell - down-regulation of cellular secretion - down-regulation of secretion by cell - downregulation of cellular secretion - downregulation of secretion by cell - negative regulation of cellular secretion - inhibition of cellular secretion - inhibition of secretion by cell - biological_process - GO:1903531 - negative regulation of secretion by cell - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell. - GOC:TermGenie - GOC:pm - GO_REF:0000058 - PMID:12130530 - - - - - down regulation of cellular secretion - GOC:TermGenie - - - - - down regulation of secretion by cell - GOC:TermGenie - - - - - down-regulation of cellular secretion - GOC:TermGenie - - - - - down-regulation of secretion by cell - GOC:TermGenie - - - - - downregulation of cellular secretion - GOC:TermGenie - - - - - downregulation of secretion by cell - GOC:TermGenie - - - - - negative regulation of cellular secretion - GOC:TermGenie - - - - - inhibition of cellular secretion - GOC:TermGenie - - - - - inhibition of secretion by cell - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of secretion by cell. - pm - 2014-10-08T13:25:17Z - positive regulation of cellular secretion - up regulation of cellular secretion - up regulation of secretion by cell - up-regulation of cellular secretion - up-regulation of secretion by cell - upregulation of cellular secretion - upregulation of secretion by cell - activation of cellular secretion - activation of secretion by cell - biological_process - GO:1903532 - positive regulation of secretion by cell - - - - - Any process that activates or increases the frequency, rate or extent of secretion by cell. - GOC:TermGenie - GOC:pm - GO_REF:0000058 - PMID:12130530 - - - - - positive regulation of cellular secretion - GOC:TermGenie - - - - - up regulation of cellular secretion - GOC:TermGenie - - - - - up regulation of secretion by cell - GOC:TermGenie - - - - - up-regulation of cellular secretion - GOC:TermGenie - - - - - up-regulation of secretion by cell - GOC:TermGenie - - - - - upregulation of cellular secretion - GOC:TermGenie - - - - - upregulation of secretion by cell - GOC:TermGenie - - - - - activation of cellular secretion - GOC:TermGenie - - - - - activation of secretion by cell - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any meiotic cell cycle process that is involved in oocyte maturation. - pr - 2014-10-09T10:46:14Z - meiosis involved in oocyte maturation - biological_process - GO:1903537 - meiotic cell cycle process involved in oocyte maturation - - - - - Any meiotic cell cycle process that is involved in oocyte maturation. - GOC:TermGenie - GOC:jz - GO_REF:0000060 - PMID:25212395 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. - pr - 2014-10-09T10:52:38Z - regulation of meiosis involved in oocyte maturation - biological_process - GO:1903538 - regulation of meiotic cell cycle process involved in oocyte maturation - - - - - Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. - GOC:TermGenie - GOC:jz - GO_REF:0000058 - PMID:25212395 - - - - - regulation of meiosis involved in oocyte maturation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of exosomal secretion. - pga - 2014-10-14T11:38:52Z - regulation of exosomal secretory pathway - regulation of extracellular vesicular exosome secretion - regulation of secretion of exosome - regulation of exosomal protein secretion - biological_process - GO:1903541 - regulation of exosomal secretion - - - - - Any process that modulates the frequency, rate or extent of exosomal secretion. - GOC:TermGenie - GO_REF:0000058 - PMID:24105262 - - - - - regulation of exosomal secretory pathway - GOC:TermGenie - - - - - regulation of extracellular vesicular exosome secretion - GOC:TermGenie - - - - - regulation of secretion of exosome - GOC:TermGenie - - - - - regulation of exosomal protein secretion - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion. - pga - 2014-10-14T11:39:02Z - down regulation of exosomal secretion - down regulation of exosomal secretory pathway - down regulation of extracellular vesicular exosome secretion - down regulation of secretion of exosome - down-regulation of exosomal secretion - down-regulation of exosomal secretory pathway - down-regulation of extracellular vesicular exosome secretion - down-regulation of secretion of exosome - downregulation of exosomal secretion - downregulation of exosomal secretory pathway - downregulation of extracellular vesicular exosome secretion - downregulation of secretion of exosome - negative regulation of exosomal secretory pathway - negative regulation of extracellular vesicular exosome secretion - negative regulation of secretion of exosome - down regulation of exosomal protein secretion - down-regulation of exosomal protein secretion - downregulation of exosomal protein secretion - inhibition of exosomal protein secretion - inhibition of exosomal secretion - inhibition of exosomal secretory pathway - inhibition of extracellular vesicular exosome secretion - inhibition of secretion of exosome - negative regulation of exosomal protein secretion - biological_process - GO:1903542 - negative regulation of exosomal secretion - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion. - GOC:TermGenie - GO_REF:0000058 - PMID:24105262 - - - - - down regulation of exosomal secretion - GOC:TermGenie - - - - - down regulation of exosomal secretory pathway - GOC:TermGenie - - - - - down regulation of extracellular vesicular exosome secretion - GOC:TermGenie - - - - - down regulation of secretion of exosome - GOC:TermGenie - - - - - down-regulation of exosomal secretion - GOC:TermGenie - - - - - down-regulation of exosomal secretory pathway - GOC:TermGenie - - - - - down-regulation of extracellular vesicular exosome secretion - GOC:TermGenie - - - - - down-regulation of secretion of exosome - GOC:TermGenie - - - - - downregulation of exosomal secretion - GOC:TermGenie - - - - - downregulation of exosomal secretory pathway - GOC:TermGenie - - - - - downregulation of extracellular vesicular exosome secretion - GOC:TermGenie - - - - - downregulation of secretion of exosome - GOC:TermGenie - - - - - negative regulation of exosomal secretory pathway - GOC:TermGenie - - - - - negative regulation of extracellular vesicular exosome secretion - GOC:TermGenie - - - - - negative regulation of secretion of exosome - GOC:TermGenie - - - - - down regulation of exosomal protein secretion - GOC:TermGenie - - - - - down-regulation of exosomal protein secretion - GOC:TermGenie - - - - - downregulation of exosomal protein secretion - GOC:TermGenie - - - - - inhibition of exosomal protein secretion - GOC:TermGenie - - - - - inhibition of exosomal secretion - GOC:TermGenie - - - - - inhibition of exosomal secretory pathway - GOC:TermGenie - - - - - inhibition of extracellular vesicular exosome secretion - GOC:TermGenie - - - - - inhibition of secretion of exosome - GOC:TermGenie - - - - - negative regulation of exosomal protein secretion - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of exosomal secretion. - pga - 2014-10-14T11:39:10Z - positive regulation of exosomal secretory pathway - positive regulation of extracellular vesicular exosome secretion - positive regulation of secretion of exosome - up regulation of exosomal secretion - up regulation of exosomal secretory pathway - up regulation of extracellular vesicular exosome secretion - up regulation of secretion of exosome - up-regulation of exosomal secretion - up-regulation of exosomal secretory pathway - up-regulation of extracellular vesicular exosome secretion - up-regulation of secretion of exosome - upregulation of exosomal secretion - upregulation of exosomal secretory pathway - upregulation of extracellular vesicular exosome secretion - upregulation of secretion of exosome - activation of exosomal protein secretion - activation of exosomal secretion - activation of exosomal secretory pathway - activation of extracellular vesicular exosome secretion - activation of secretion of exosome - positive regulation of exosomal protein secretion - up regulation of exosomal protein secretion - up-regulation of exosomal protein secretion - upregulation of exosomal protein secretion - biological_process - GO:1903543 - positive regulation of exosomal secretion - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of exosomal secretion. - GOC:TermGenie - GO_REF:0000058 - PMID:24105262 - - - - - positive regulation of exosomal secretory pathway - GOC:TermGenie - - - - - positive regulation of extracellular vesicular exosome secretion - GOC:TermGenie - - - - - positive regulation of secretion of exosome - GOC:TermGenie - - - - - up regulation of exosomal secretion - GOC:TermGenie - - - - - up regulation of exosomal secretory pathway - GOC:TermGenie - - - - - up regulation of extracellular vesicular exosome secretion - GOC:TermGenie - - - - - up regulation of secretion of exosome - GOC:TermGenie - - - - - up-regulation of exosomal secretion - GOC:TermGenie - - - - - up-regulation of exosomal secretory pathway - GOC:TermGenie - - - - - up-regulation of extracellular vesicular exosome secretion - GOC:TermGenie - - - - - up-regulation of secretion of exosome - GOC:TermGenie - - - - - upregulation of exosomal secretion - GOC:TermGenie - - - - - upregulation of exosomal secretory pathway - GOC:TermGenie - - - - - upregulation of extracellular vesicular exosome secretion - GOC:TermGenie - - - - - upregulation of secretion of exosome - GOC:TermGenie - - - - - activation of exosomal protein secretion - GOC:TermGenie - - - - - activation of exosomal secretion - GOC:TermGenie - - - - - activation of exosomal secretory pathway - GOC:TermGenie - - - - - activation of extracellular vesicular exosome secretion - GOC:TermGenie - - - - - activation of secretion of exosome - GOC:TermGenie - - - - - positive regulation of exosomal protein secretion - GOC:TermGenie - - - - - up regulation of exosomal protein secretion - GOC:TermGenie - - - - - up-regulation of exosomal protein secretion - GOC:TermGenie - - - - - upregulation of exosomal protein secretion - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly. - pga - 2014-10-20T15:37:25Z - regulation of extracellular vesicular exosome assembly - biological_process - GO:1903551 - regulation of extracellular exosome assembly - - - - - Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly. - GOC:TermGenie - GO_REF:0000058 - PMID:24105262 - - - - - regulation of extracellular vesicular exosome assembly - GOC:vesicles - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly. - pga - 2014-10-20T15:37:33Z - down regulation of extracellular vesicular exosome assembly - down-regulation of extracellular vesicular exosome assembly - downregulation of extracellular vesicular exosome assembly - negative regulation of extracellular vesicular exosome assembly - inhibition of extracellular vesicular exosome assembly - biological_process - GO:1903552 - negative regulation of extracellular exosome assembly - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly. - GOC:TermGenie - GO_REF:0000058 - PMID:24105262 - - - - - down regulation of extracellular vesicular exosome assembly - GOC:TermGenie - - - - - down-regulation of extracellular vesicular exosome assembly - GOC:TermGenie - - - - - downregulation of extracellular vesicular exosome assembly - GOC:TermGenie - - - - - negative regulation of extracellular vesicular exosome assembly - GOC:vesicles - - - - - inhibition of extracellular vesicular exosome assembly - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly. - pga - 2014-10-20T15:37:42Z - up regulation of extracellular vesicular exosome assembly - up-regulation of extracellular vesicular exosome assembly - upregulation of extracellular vesicular exosome assembly - activation of extracellular vesicular exosome assembly - biological_process - positive regulation of extracellular vesicular exosome assembly - GO:1903553 - positive regulation of extracellular exosome assembly - - - - - Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly. - GOC:TermGenie - GO_REF:0000058 - PMID:24105262 - - - - - up regulation of extracellular vesicular exosome assembly - GOC:TermGenie - - - - - up-regulation of extracellular vesicular exosome assembly - GOC:TermGenie - - - - - upregulation of extracellular vesicular exosome assembly - GOC:TermGenie - - - - - activation of extracellular vesicular exosome assembly - GOC:TermGenie - - - - - positive regulation of extracellular vesicular exosome assembly - GOC:vesicles - - - - - - - - - - - - - - - - - - - - - - - - - - - Any vesicle that is part of the extracellular region. - jl - 2014-10-22T14:26:11Z - cellular_component - microparticle - GO:1903561 - extracellular vesicle - - - - - Any vesicle that is part of the extracellular region. - GOC:TermGenie - GOC:pm - GO_REF:0000064 - PMID:24769233 - - - - - microparticle - GOC:vesicles - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of protein localization to cilium. - krc - 2014-10-24T20:58:11Z - biological_process - GO:1903564 - regulation of protein localization to cilium - - - - - Any process that modulates the frequency, rate or extent of protein localization to cilium. - GOC:TermGenie - GOC:cilia - GOC:krc - GO_REF:0000058 - PMID:22072986 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium. - krc - 2014-10-24T20:58:20Z - down regulation of protein localization to cilium - down-regulation of protein localization to cilium - downregulation of protein localization to cilium - inhibition of protein localization to cilium - biological_process - GO:1903565 - negative regulation of protein localization to cilium - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium. - GOC:TermGenie - GOC:cilia - GOC:krc - GO_REF:0000058 - PMID:22072986 - - - - - down regulation of protein localization to cilium - GOC:TermGenie - - - - - down-regulation of protein localization to cilium - GOC:TermGenie - - - - - downregulation of protein localization to cilium - GOC:TermGenie - - - - - inhibition of protein localization to cilium - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to cilium. - krc - 2014-10-24T20:58:28Z - up regulation of protein localization to cilium - up-regulation of protein localization to cilium - upregulation of protein localization to cilium - activation of protein localization to cilium - biological_process - GO:1903566 - positive regulation of protein localization to cilium - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to cilium. - GOC:TermGenie - GOC:cilia - GOC:krc - GO_REF:0000058 - PMID:22072986 - - - - - up regulation of protein localization to cilium - GOC:TermGenie - - - - - up-regulation of protein localization to cilium - GOC:TermGenie - - - - - upregulation of protein localization to cilium - GOC:TermGenie - - - - - activation of protein localization to cilium - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane. - krc - 2014-10-24T21:32:51Z - regulation of protein localisation in ciliary membrane - regulation of protein localisation to ciliary membrane - regulation of protein localization in ciliary membrane - biological_process - GO:1903567 - regulation of protein localization to ciliary membrane - - - - - Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane. - GOC:TermGenie - GOC:cilia - GOC:krc - GO_REF:0000058 - PMID:22072986 - - - - - regulation of protein localisation in ciliary membrane - GOC:TermGenie - - - - - regulation of protein localisation to ciliary membrane - GOC:TermGenie - - - - - regulation of protein localization in ciliary membrane - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane. - krc - 2014-10-24T21:32:59Z - down regulation of protein localisation in ciliary membrane - down regulation of protein localisation to ciliary membrane - down regulation of protein localization in ciliary membrane - down regulation of protein localization to ciliary membrane - down-regulation of protein localisation in ciliary membrane - down-regulation of protein localisation to ciliary membrane - down-regulation of protein localization in ciliary membrane - down-regulation of protein localization to ciliary membrane - downregulation of protein localisation in ciliary membrane - downregulation of protein localisation to ciliary membrane - downregulation of protein localization in ciliary membrane - downregulation of protein localization to ciliary membrane - negative regulation of protein localisation in ciliary membrane - negative regulation of protein localisation to ciliary membrane - negative regulation of protein localization in ciliary membrane - inhibition of protein localisation in ciliary membrane - inhibition of protein localisation to ciliary membrane - inhibition of protein localization in ciliary membrane - inhibition of protein localization to ciliary membrane - biological_process - GO:1903568 - negative regulation of protein localization to ciliary membrane - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane. - GOC:TermGenie - GOC:cilia - GOC:krc - GO_REF:0000058 - PMID:22072986 - - - - - down regulation of protein localisation in ciliary membrane - GOC:TermGenie - - - - - down regulation of protein localisation to ciliary membrane - GOC:TermGenie - - - - - down regulation of protein localization in ciliary membrane - GOC:TermGenie - - - - - down regulation of protein localization to ciliary membrane - GOC:TermGenie - - - - - down-regulation of protein localisation in ciliary membrane - GOC:TermGenie - - - - - down-regulation of protein localisation to ciliary membrane - GOC:TermGenie - - - - - down-regulation of protein localization in ciliary membrane - GOC:TermGenie - - - - - down-regulation of protein localization to ciliary membrane - GOC:TermGenie - - - - - downregulation of protein localisation in ciliary membrane - GOC:TermGenie - - - - - downregulation of protein localisation to ciliary membrane - GOC:TermGenie - - - - - downregulation of protein localization in ciliary membrane - GOC:TermGenie - - - - - downregulation of protein localization to ciliary membrane - GOC:TermGenie - - - - - negative regulation of protein localisation in ciliary membrane - GOC:TermGenie - - - - - negative regulation of protein localisation to ciliary membrane - GOC:TermGenie - - - - - negative regulation of protein localization in ciliary membrane - GOC:TermGenie - - - - - inhibition of protein localisation in ciliary membrane - GOC:TermGenie - - - - - inhibition of protein localisation to ciliary membrane - GOC:TermGenie - - - - - inhibition of protein localization in ciliary membrane - GOC:TermGenie - - - - - inhibition of protein localization to ciliary membrane - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane. - krc - 2014-10-24T21:33:08Z - positive regulation of protein localisation in ciliary membrane - positive regulation of protein localisation to ciliary membrane - positive regulation of protein localization in ciliary membrane - up regulation of protein localisation in ciliary membrane - up regulation of protein localisation to ciliary membrane - up regulation of protein localization in ciliary membrane - up regulation of protein localization to ciliary membrane - up-regulation of protein localisation in ciliary membrane - up-regulation of protein localisation to ciliary membrane - up-regulation of protein localization in ciliary membrane - up-regulation of protein localization to ciliary membrane - upregulation of protein localisation in ciliary membrane - upregulation of protein localisation to ciliary membrane - upregulation of protein localization in ciliary membrane - upregulation of protein localization to ciliary membrane - activation of protein localisation in ciliary membrane - activation of protein localisation to ciliary membrane - activation of protein localization in ciliary membrane - activation of protein localization to ciliary membrane - biological_process - GO:1903569 - positive regulation of protein localization to ciliary membrane - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane. - GOC:TermGenie - GOC:cilia - GOC:krc - GO_REF:0000058 - PMID:22072986 - - - - - positive regulation of protein localisation in ciliary membrane - GOC:TermGenie - - - - - positive regulation of protein localisation to ciliary membrane - GOC:TermGenie - - - - - positive regulation of protein localization in ciliary membrane - GOC:TermGenie - - - - - up regulation of protein localisation in ciliary membrane - GOC:TermGenie - - - - - up regulation of protein localisation to ciliary membrane - GOC:TermGenie - - - - - up regulation of protein localization in ciliary membrane - GOC:TermGenie - - - - - up regulation of protein localization to ciliary membrane - GOC:TermGenie - - - - - up-regulation of protein localisation in ciliary membrane - GOC:TermGenie - - - - - up-regulation of protein localisation to ciliary membrane - GOC:TermGenie - - - - - up-regulation of protein localization in ciliary membrane - GOC:TermGenie - - - - - up-regulation of protein localization to ciliary membrane - GOC:TermGenie - - - - - upregulation of protein localisation in ciliary membrane - GOC:TermGenie - - - - - upregulation of protein localisation to ciliary membrane - GOC:TermGenie - - - - - upregulation of protein localization in ciliary membrane - GOC:TermGenie - - - - - upregulation of protein localization to ciliary membrane - GOC:TermGenie - - - - - activation of protein localisation in ciliary membrane - GOC:TermGenie - - - - - activation of protein localisation to ciliary membrane - GOC:TermGenie - - - - - activation of protein localization in ciliary membrane - GOC:TermGenie - - - - - activation of protein localization to ciliary membrane - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of DNA catabolic process. - sl - 2014-11-19T22:36:35Z - regulation of DNA breakdown - regulation of DNA catabolism - regulation of DNA degradation - biological_process - GO:1903624 - regulation of DNA catabolic process - - - - - Any process that modulates the frequency, rate or extent of DNA catabolic process. - GOC:TermGenie - GO_REF:0000058 - PMID:2001740 - - - - - regulation of DNA breakdown - GOC:TermGenie - - - - - regulation of DNA catabolism - GOC:TermGenie - - - - - regulation of DNA degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process. - sl - 2014-11-19T22:36:43Z - down regulation of DNA breakdown - down regulation of DNA catabolic process - down regulation of DNA catabolism - down regulation of DNA degradation - down-regulation of DNA breakdown - down-regulation of DNA catabolic process - down-regulation of DNA catabolism - down-regulation of DNA degradation - downregulation of DNA breakdown - downregulation of DNA catabolic process - downregulation of DNA catabolism - downregulation of DNA degradation - negative regulation of DNA breakdown - negative regulation of DNA catabolism - negative regulation of DNA degradation - inhibition of DNA breakdown - inhibition of DNA catabolic process - inhibition of DNA catabolism - inhibition of DNA degradation - biological_process - GO:1903625 - negative regulation of DNA catabolic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process. - GOC:TermGenie - GO_REF:0000058 - PMID:2001740 - - - - - down regulation of DNA breakdown - GOC:TermGenie - - - - - down regulation of DNA catabolic process - GOC:TermGenie - - - - - down regulation of DNA catabolism - GOC:TermGenie - - - - - down regulation of DNA degradation - GOC:TermGenie - - - - - down-regulation of DNA breakdown - GOC:TermGenie - - - - - down-regulation of DNA catabolic process - GOC:TermGenie - - - - - down-regulation of DNA catabolism - GOC:TermGenie - - - - - down-regulation of DNA degradation - GOC:TermGenie - - - - - downregulation of DNA breakdown - GOC:TermGenie - - - - - downregulation of DNA catabolic process - GOC:TermGenie - - - - - downregulation of DNA catabolism - GOC:TermGenie - - - - - downregulation of DNA degradation - GOC:TermGenie - - - - - negative regulation of DNA breakdown - GOC:TermGenie - - - - - negative regulation of DNA catabolism - GOC:TermGenie - - - - - negative regulation of DNA degradation - GOC:TermGenie - - - - - inhibition of DNA breakdown - GOC:TermGenie - - - - - inhibition of DNA catabolic process - GOC:TermGenie - - - - - inhibition of DNA catabolism - GOC:TermGenie - - - - - inhibition of DNA degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of DNA catabolic process. - sl - 2014-11-19T22:36:51Z - positive regulation of DNA breakdown - positive regulation of DNA catabolism - positive regulation of DNA degradation - up regulation of DNA breakdown - up regulation of DNA catabolic process - up regulation of DNA catabolism - up regulation of DNA degradation - up-regulation of DNA breakdown - up-regulation of DNA catabolic process - up-regulation of DNA catabolism - up-regulation of DNA degradation - upregulation of DNA breakdown - upregulation of DNA catabolic process - upregulation of DNA catabolism - upregulation of DNA degradation - activation of DNA breakdown - activation of DNA catabolic process - activation of DNA catabolism - activation of DNA degradation - biological_process - GO:1903626 - positive regulation of DNA catabolic process - - - - - Any process that activates or increases the frequency, rate or extent of DNA catabolic process. - GOC:TermGenie - GO_REF:0000058 - PMID:2001740 - - - - - positive regulation of DNA breakdown - GOC:TermGenie - - - - - positive regulation of DNA catabolism - GOC:TermGenie - - - - - positive regulation of DNA degradation - GOC:TermGenie - - - - - up regulation of DNA breakdown - GOC:TermGenie - - - - - up regulation of DNA catabolic process - GOC:TermGenie - - - - - up regulation of DNA catabolism - GOC:TermGenie - - - - - up regulation of DNA degradation - GOC:TermGenie - - - - - up-regulation of DNA breakdown - GOC:TermGenie - - - - - up-regulation of DNA catabolic process - GOC:TermGenie - - - - - up-regulation of DNA catabolism - GOC:TermGenie - - - - - up-regulation of DNA degradation - GOC:TermGenie - - - - - upregulation of DNA breakdown - GOC:TermGenie - - - - - upregulation of DNA catabolic process - GOC:TermGenie - - - - - upregulation of DNA catabolism - GOC:TermGenie - - - - - upregulation of DNA degradation - GOC:TermGenie - - - - - activation of DNA breakdown - GOC:TermGenie - - - - - activation of DNA catabolic process - GOC:TermGenie - - - - - activation of DNA catabolism - GOC:TermGenie - - - - - activation of DNA degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly. - als - 2014-12-03T11:45:08Z - down regulation of microvillus assembly - down-regulation of microvillus assembly - downregulation of microvillus assembly - inhibition of microvillus assembly - biological_process - down regulation of microvillus biogenesis - down-regulation of microvillus biogenesis - downregulation of microvillus biogenesis - inhibition of microvillus biogenesis - negative regulation of microvillus biogenesis - GO:1903697 - negative regulation of microvillus assembly - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly. - GOC:TermGenie - GOC:als - GO_REF:0000058 - PMID:22797597 - - - - - down regulation of microvillus assembly - GOC:TermGenie - - - - - down-regulation of microvillus assembly - GOC:TermGenie - - - - - downregulation of microvillus assembly - GOC:TermGenie - - - - - inhibition of microvillus assembly - GOC:TermGenie - - - - - down regulation of microvillus biogenesis - GOC:TermGenie - - - - - down-regulation of microvillus biogenesis - GOC:TermGenie - - - - - downregulation of microvillus biogenesis - GOC:TermGenie - - - - - inhibition of microvillus biogenesis - GOC:TermGenie - - - - - negative regulation of microvillus biogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of microvillus assembly. - als - 2014-12-03T11:45:17Z - up regulation of microvillus assembly - up-regulation of microvillus assembly - upregulation of microvillus assembly - activation of microvillus assembly - biological_process - activation of microvillus biogenesis - positive regulation of microvillus biogenesis - up regulation of microvillus biogenesis - up-regulation of microvillus biogenesis - upregulation of microvillus biogenesis - GO:1903698 - positive regulation of microvillus assembly - - - - - Any process that activates or increases the frequency, rate or extent of microvillus assembly. - GOC:TermGenie - GOC:als - GO_REF:0000058 - PMID:22797597 - - - - - up regulation of microvillus assembly - GOC:TermGenie - - - - - up-regulation of microvillus assembly - GOC:TermGenie - - - - - upregulation of microvillus assembly - GOC:TermGenie - - - - - activation of microvillus assembly - GOC:TermGenie - - - - - activation of microvillus biogenesis - GOC:TermGenie - - - - - positive regulation of microvillus biogenesis - GOC:TermGenie - - - - - up regulation of microvillus biogenesis - GOC:TermGenie - - - - - up-regulation of microvillus biogenesis - GOC:TermGenie - - - - - upregulation of microvillus biogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure. - cls - 2014-12-03T13:12:09Z - corneal stroma development - stroma of cornea development - biological_process - substantia propria development - GO:1903701 - substantia propria of cornea development - - - - - The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure. - GOC:TermGenie - GO_REF:0000094 - PMID:12556382 - - - - - corneal stroma development - GOC:TermGenie - - - - - stroma of cornea development - GOC:TermGenie - - - - - substantia propria development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure. - cls - 2014-12-03T14:41:30Z - esophageal development - gullet development - oesophagus development - biological_process - GO:1903702 - esophagus development - - - - - The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure. - GOC:TermGenie - GO_REF:0000094 - ISBN:0-683-40008-8 - - - - - esophageal development - MGI:csmith - - - - - gullet development - GOC:TermGenie - - - - - oesophagus development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of hemopoiesis. - pad - 2014-12-04T15:34:13Z - regulation of blood cell biosynthesis - regulation of blood cell formation - regulation of haemopoiesis - regulation of hematopoiesis - biological_process - GO:1903706 - An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. - regulation of hemopoiesis - - - - - Any process that modulates the frequency, rate or extent of hemopoiesis. - GOC:PARL - GOC:TermGenie - GOC:pad - GO_REF:0000058 - PMID:20080761 - - - - - regulation of blood cell biosynthesis - GOC:TermGenie - - - - - regulation of blood cell formation - GOC:TermGenie - - - - - regulation of haemopoiesis - GOC:TermGenie - - - - - regulation of hematopoiesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. - pad - 2014-12-04T15:34:21Z - down regulation of blood cell biosynthesis - down regulation of blood cell formation - down regulation of haemopoiesis - down regulation of hematopoiesis - down regulation of hemopoiesis - down-regulation of blood cell biosynthesis - down-regulation of blood cell formation - down-regulation of haemopoiesis - down-regulation of hematopoiesis - down-regulation of hemopoiesis - downregulation of blood cell biosynthesis - downregulation of blood cell formation - downregulation of haemopoiesis - downregulation of hematopoiesis - downregulation of hemopoiesis - negative regulation of blood cell biosynthesis - negative regulation of blood cell formation - negative regulation of haemopoiesis - negative regulation of hematopoiesis - inhibition of blood cell biosynthesis - inhibition of blood cell formation - inhibition of haemopoiesis - inhibition of hematopoiesis - inhibition of hemopoiesis - biological_process - GO:1903707 - An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. - negative regulation of hemopoiesis - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. - GOC:PARL - GOC:TermGenie - GOC:pad - GO_REF:0000058 - PMID:20080761 - - - - - down regulation of blood cell biosynthesis - GOC:TermGenie - - - - - down regulation of blood cell formation - GOC:TermGenie - - - - - down regulation of haemopoiesis - GOC:TermGenie - - - - - down regulation of hematopoiesis - GOC:TermGenie - - - - - down regulation of hemopoiesis - GOC:TermGenie - - - - - down-regulation of blood cell biosynthesis - GOC:TermGenie - - - - - down-regulation of blood cell formation - GOC:TermGenie - - - - - down-regulation of haemopoiesis - GOC:TermGenie - - - - - down-regulation of hematopoiesis - GOC:TermGenie - - - - - down-regulation of hemopoiesis - GOC:TermGenie - - - - - downregulation of blood cell biosynthesis - GOC:TermGenie - - - - - downregulation of blood cell formation - GOC:TermGenie - - - - - downregulation of haemopoiesis - GOC:TermGenie - - - - - downregulation of hematopoiesis - GOC:TermGenie - - - - - downregulation of hemopoiesis - GOC:TermGenie - - - - - negative regulation of blood cell biosynthesis - GOC:TermGenie - - - - - negative regulation of blood cell formation - GOC:TermGenie - - - - - negative regulation of haemopoiesis - GOC:TermGenie - - - - - negative regulation of hematopoiesis - GOC:TermGenie - - - - - inhibition of blood cell biosynthesis - GOC:TermGenie - - - - - inhibition of blood cell formation - GOC:TermGenie - - - - - inhibition of haemopoiesis - GOC:TermGenie - - - - - inhibition of hematopoiesis - GOC:TermGenie - - - - - inhibition of hemopoiesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of hemopoiesis. - pad - 2014-12-04T15:34:30Z - positive regulation of blood cell biosynthesis - positive regulation of blood cell formation - positive regulation of haemopoiesis - positive regulation of hematopoiesis - up regulation of blood cell biosynthesis - up regulation of blood cell formation - up regulation of haemopoiesis - up regulation of hematopoiesis - up regulation of hemopoiesis - up-regulation of blood cell biosynthesis - up-regulation of blood cell formation - up-regulation of haemopoiesis - up-regulation of hematopoiesis - up-regulation of hemopoiesis - upregulation of blood cell biosynthesis - upregulation of blood cell formation - upregulation of haemopoiesis - upregulation of hematopoiesis - upregulation of hemopoiesis - activation of blood cell biosynthesis - activation of blood cell formation - activation of haemopoiesis - activation of hematopoiesis - activation of hemopoiesis - biological_process - GO:1903708 - An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. - positive regulation of hemopoiesis - - - - - Any process that activates or increases the frequency, rate or extent of hemopoiesis. - GOC:PARL - GOC:TermGenie - GOC:pad - GO_REF:0000058 - PMID:20080761 - - - - - positive regulation of blood cell biosynthesis - GOC:TermGenie - - - - - positive regulation of blood cell formation - GOC:TermGenie - - - - - positive regulation of haemopoiesis - GOC:TermGenie - - - - - positive regulation of hematopoiesis - GOC:TermGenie - - - - - up regulation of blood cell biosynthesis - GOC:TermGenie - - - - - up regulation of blood cell formation - GOC:TermGenie - - - - - up regulation of haemopoiesis - GOC:TermGenie - - - - - up regulation of hematopoiesis - GOC:TermGenie - - - - - up regulation of hemopoiesis - GOC:TermGenie - - - - - up-regulation of blood cell biosynthesis - GOC:TermGenie - - - - - up-regulation of blood cell formation - GOC:TermGenie - - - - - up-regulation of haemopoiesis - GOC:TermGenie - - - - - up-regulation of hematopoiesis - GOC:TermGenie - - - - - up-regulation of hemopoiesis - GOC:TermGenie - - - - - upregulation of blood cell biosynthesis - GOC:TermGenie - - - - - upregulation of blood cell formation - GOC:TermGenie - - - - - upregulation of haemopoiesis - GOC:TermGenie - - - - - upregulation of hematopoiesis - GOC:TermGenie - - - - - upregulation of hemopoiesis - GOC:TermGenie - - - - - activation of blood cell biosynthesis - GOC:TermGenie - - - - - activation of blood cell formation - GOC:TermGenie - - - - - activation of haemopoiesis - GOC:TermGenie - - - - - activation of hematopoiesis - GOC:TermGenie - - - - - activation of hemopoiesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of plasma membrane organization. - al - 2014-12-10T18:59:44Z - regulation of plasma membrane organisation - biological_process - regulation of plasma membrane organization and biogenesis - GO:1903729 - regulation of plasma membrane organization - - - - - Any process that modulates the frequency, rate or extent of plasma membrane organization. - GOC:TermGenie - GO_REF:0000058 - PMID:24514900 - - - - - regulation of plasma membrane organisation - GOC:TermGenie - - - - - regulation of plasma membrane organization and biogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane. - mah - 2015-01-07T13:15:54Z - protein localisation in vacuolar membrane - protein localisation to vacuolar membrane - protein localization in vacuolar membrane - biological_process - GO:1903778 - protein localization to vacuolar membrane - - - - - A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane. - GOC:TermGenie - GO_REF:0000087 - PMID:25378562 - - - - - protein localisation in vacuolar membrane - GOC:TermGenie - - - - - protein localisation to vacuolar membrane - GOC:TermGenie - - - - - protein localization in vacuolar membrane - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cardiac conduction. - rph - 2015-01-07T13:20:11Z - biological_process - GO:1903779 - regulation of cardiac conduction - - - - - Any process that modulates the frequency, rate or extent of cardiac conduction. - GOC:BHF - GOC:TermGenie - GOC:mtg_cardiac_conduct_nov11 - GOC:rph - GO_REF:0000058 - PMID:12967627 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction. - rph - 2015-01-07T13:20:20Z - down regulation of cardiac conduction - down-regulation of cardiac conduction - downregulation of cardiac conduction - inhibition of cardiac conduction - biological_process - GO:1903780 - negative regulation of cardiac conduction - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction. - GOC:BHF - GOC:TermGenie - GOC:mtg_cardiac_conduct_nov11 - GOC:rph - GO_REF:0000058 - PMID:12967627 - - - - - down regulation of cardiac conduction - GOC:TermGenie - - - - - down-regulation of cardiac conduction - GOC:TermGenie - - - - - downregulation of cardiac conduction - GOC:TermGenie - - - - - inhibition of cardiac conduction - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cardiac conduction. - rph - 2015-01-07T13:20:28Z - up regulation of cardiac conduction - up-regulation of cardiac conduction - upregulation of cardiac conduction - activation of cardiac conduction - biological_process - GO:1903781 - positive regulation of cardiac conduction - - - - - Any process that activates or increases the frequency, rate or extent of cardiac conduction. - GOC:BHF - GOC:TermGenie - GOC:mtg_cardiac_conduct_nov11 - GOC:rph - GO_REF:0000058 - PMID:12967627 - - - - - up regulation of cardiac conduction - GOC:TermGenie - - - - - up-regulation of cardiac conduction - GOC:TermGenie - - - - - upregulation of cardiac conduction - GOC:TermGenie - - - - - activation of cardiac conduction - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of amino acid transmembrane transport. - al - 2015-01-08T17:42:18Z - regulation of amino acid membrane transport - biological_process - GO:1903789 - regulation of amino acid transmembrane transport - - - - - Any process that modulates the frequency, rate or extent of amino acid transmembrane transport. - GOC:TermGenie - GO_REF:0000058 - PMID:16115814 - - - - - regulation of amino acid membrane transport - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of inorganic anion transmembrane transport. - sl - 2015-01-14T21:44:49Z - regulation of inorganic anion membrane transport - regulation of transmembrane inorganic anion transport - biological_process - GO:1903795 - regulation of inorganic anion transmembrane transport - - - - - Any process that modulates the frequency, rate or extent of inorganic anion transmembrane transport. - GOC:TermGenie - GO_REF:0000058 - PMID:11336802 - - - - - regulation of inorganic anion membrane transport - GOC:TermGenie - - - - - regulation of transmembrane inorganic anion transport - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of inorganic anion transmembrane transport. - sl - 2015-01-14T21:44:59Z - down regulation of inorganic anion membrane transport - down regulation of inorganic anion transmembrane transport - down regulation of transmembrane inorganic anion transport - down-regulation of inorganic anion membrane transport - down-regulation of inorganic anion transmembrane transport - down-regulation of transmembrane inorganic anion transport - downregulation of inorganic anion membrane transport - downregulation of inorganic anion transmembrane transport - downregulation of transmembrane inorganic anion transport - negative regulation of inorganic anion membrane transport - negative regulation of transmembrane inorganic anion transport - inhibition of inorganic anion membrane transport - inhibition of inorganic anion transmembrane transport - inhibition of transmembrane inorganic anion transport - biological_process - GO:1903796 - negative regulation of inorganic anion transmembrane transport - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of inorganic anion transmembrane transport. - GOC:TermGenie - GO_REF:0000058 - PMID:11336802 - - - - - down regulation of inorganic anion membrane transport - GOC:TermGenie - - - - - down regulation of inorganic anion transmembrane transport - GOC:TermGenie - - - - - down regulation of transmembrane inorganic anion transport - GOC:TermGenie - - - - - down-regulation of inorganic anion membrane transport - GOC:TermGenie - - - - - down-regulation of inorganic anion transmembrane transport - GOC:TermGenie - - - - - down-regulation of transmembrane inorganic anion transport - GOC:TermGenie - - - - - downregulation of inorganic anion membrane transport - GOC:TermGenie - - - - - downregulation of inorganic anion transmembrane transport - GOC:TermGenie - - - - - downregulation of transmembrane inorganic anion transport - GOC:TermGenie - - - - - negative regulation of inorganic anion membrane transport - GOC:TermGenie - - - - - negative regulation of transmembrane inorganic anion transport - GOC:TermGenie - - - - - inhibition of inorganic anion membrane transport - GOC:TermGenie - - - - - inhibition of inorganic anion transmembrane transport - GOC:TermGenie - - - - - inhibition of transmembrane inorganic anion transport - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of inorganic anion transmembrane transport. - sl - 2015-01-14T21:45:08Z - positive regulation of inorganic anion membrane transport - positive regulation of transmembrane inorganic anion transport - up regulation of inorganic anion membrane transport - up regulation of inorganic anion transmembrane transport - up regulation of transmembrane inorganic anion transport - up-regulation of inorganic anion membrane transport - up-regulation of inorganic anion transmembrane transport - up-regulation of transmembrane inorganic anion transport - upregulation of inorganic anion membrane transport - upregulation of inorganic anion transmembrane transport - upregulation of transmembrane inorganic anion transport - activation of inorganic anion membrane transport - activation of inorganic anion transmembrane transport - activation of transmembrane inorganic anion transport - biological_process - GO:1903797 - positive regulation of inorganic anion transmembrane transport - - - - - Any process that activates or increases the frequency, rate or extent of inorganic anion transmembrane transport. - GOC:TermGenie - GO_REF:0000058 - PMID:11336802 - - - - - positive regulation of inorganic anion membrane transport - GOC:TermGenie - - - - - positive regulation of transmembrane inorganic anion transport - GOC:TermGenie - - - - - up regulation of inorganic anion membrane transport - GOC:TermGenie - - - - - up regulation of inorganic anion transmembrane transport - GOC:TermGenie - - - - - up regulation of transmembrane inorganic anion transport - GOC:TermGenie - - - - - up-regulation of inorganic anion membrane transport - GOC:TermGenie - - - - - up-regulation of inorganic anion transmembrane transport - GOC:TermGenie - - - - - up-regulation of transmembrane inorganic anion transport - GOC:TermGenie - - - - - upregulation of inorganic anion membrane transport - GOC:TermGenie - - - - - upregulation of inorganic anion transmembrane transport - GOC:TermGenie - - - - - upregulation of transmembrane inorganic anion transport - GOC:TermGenie - - - - - activation of inorganic anion membrane transport - GOC:TermGenie - - - - - activation of inorganic anion transmembrane transport - GOC:TermGenie - - - - - activation of transmembrane inorganic anion transport - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which an organic acid is transported across a membrane. - vw - 2015-01-20T10:20:58Z - biological_process - GO:1903825 - organic acid transmembrane transport - - - - - The process in which an organic acid is transported across a membrane. - GOC:TermGenie - GO_REF:0000069 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization. - https://github.com/geneontology/go-ontology/issues/22021 - jl - 2015-01-20T14:32:24Z - down regulation of cellular protein localisation - down regulation of cellular protein localization - down-regulation of cellular protein localisation - down-regulation of cellular protein localization - downregulation of cellular protein localisation - downregulation of cellular protein localization - negative regulation of cellular protein localisation - negative regulation of cellular protein localization - inhibition of cellular protein localisation - inhibition of cellular protein localization - biological_process - GO:1903828 - negative regulation of protein localization - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization. - GOC:TermGenie - GOC:vw - GO_REF:0000058 - - - - - down regulation of cellular protein localisation - GOC:TermGenie - - - - - down regulation of cellular protein localization - GOC:TermGenie - - - - - down-regulation of cellular protein localisation - GOC:TermGenie - - - - - down-regulation of cellular protein localization - GOC:TermGenie - - - - - downregulation of cellular protein localisation - GOC:TermGenie - - - - - downregulation of cellular protein localization - GOC:TermGenie - - - - - negative regulation of cellular protein localisation - GOC:TermGenie - - - - - inhibition of cellular protein localisation - GOC:TermGenie - - - - - inhibition of cellular protein localization - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of a protein localization. - https://github.com/geneontology/go-ontology/issues/22021 - jl - 2015-01-20T14:32:33Z - positive regulation of cellular protein localisation - positive regulation of cellular protein localization - up regulation of cellular protein localisation - up regulation of cellular protein localization - up-regulation of cellular protein localisation - up-regulation of cellular protein localization - upregulation of cellular protein localisation - upregulation of cellular protein localization - biological_process - GO:1903829 - positive regulation of protein localization - - - - - Any process that activates or increases the frequency, rate or extent of a protein localization. - GOC:TermGenie - GOC:vw - GO_REF:0000058 - - - - - positive regulation of cellular protein localisation - GOC:TermGenie - - - - - up regulation of cellular protein localisation - GOC:TermGenie - - - - - up regulation of cellular protein localization - GOC:TermGenie - - - - - up-regulation of cellular protein localisation - GOC:TermGenie - - - - - up-regulation of cellular protein localization - GOC:TermGenie - - - - - upregulation of cellular protein localisation - GOC:TermGenie - - - - - upregulation of cellular protein localization - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of aorta morphogenesis. - rph - 2015-01-23T14:00:51Z - biological_process - GO:1903847 - regulation of aorta morphogenesis - - - - - Any process that modulates the frequency, rate or extent of aorta morphogenesis. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:22269326 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis. - rph - 2015-01-23T14:01:01Z - down regulation of aorta morphogenesis - down-regulation of aorta morphogenesis - downregulation of aorta morphogenesis - inhibition of aorta morphogenesis - biological_process - GO:1903848 - negative regulation of aorta morphogenesis - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:22269326 - - - - - down regulation of aorta morphogenesis - GOC:TermGenie - - - - - down-regulation of aorta morphogenesis - GOC:TermGenie - - - - - downregulation of aorta morphogenesis - GOC:TermGenie - - - - - inhibition of aorta morphogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of aorta morphogenesis. - rph - 2015-01-23T14:01:09Z - up regulation of aorta morphogenesis - up-regulation of aorta morphogenesis - upregulation of aorta morphogenesis - activation of aorta morphogenesis - biological_process - GO:1903849 - positive regulation of aorta morphogenesis - - - - - Any process that activates or increases the frequency, rate or extent of aorta morphogenesis. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:22269326 - - - - - up regulation of aorta morphogenesis - GOC:TermGenie - - - - - up-regulation of aorta morphogenesis - GOC:TermGenie - - - - - upregulation of aorta morphogenesis - GOC:TermGenie - - - - - activation of aorta morphogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure. - cjm - 2015-02-05T00:42:16Z - biological_process - GO:1903867 - extraembryonic membrane development - - - - - The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure. - GOC:TermGenie - GO_REF:0000094 - ISBN:0073040584 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange. - sl - 2015-02-17T20:26:24Z - down regulation of respiratory gaseous exchange - down-regulation of respiratory gaseous exchange - downregulation of respiratory gaseous exchange - inhibition of respiratory gaseous exchange - biological_process - GO:1903941 - negative regulation of respiratory gaseous exchange - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange. - GOC:TermGenie - GO_REF:0000058 - PMID:22819705 - - - - - down regulation of respiratory gaseous exchange - GOC:TermGenie - - - - - down-regulation of respiratory gaseous exchange - GOC:TermGenie - - - - - downregulation of respiratory gaseous exchange - GOC:TermGenie - - - - - inhibition of respiratory gaseous exchange - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. - sl - 2015-02-17T20:26:35Z - up regulation of respiratory gaseous exchange - up-regulation of respiratory gaseous exchange - upregulation of respiratory gaseous exchange - activation of respiratory gaseous exchange - biological_process - GO:1903942 - positive regulation of respiratory gaseous exchange - - - - - Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. - GOC:TermGenie - GO_REF:0000058 - PMID:22819705 - - - - - up regulation of respiratory gaseous exchange - GOC:TermGenie - - - - - up-regulation of respiratory gaseous exchange - GOC:TermGenie - - - - - upregulation of respiratory gaseous exchange - GOC:TermGenie - - - - - activation of respiratory gaseous exchange - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process. - sl - 2015-02-19T12:54:40Z - regulation of hepatocyte apoptosis - biological_process - GO:1903943 - regulation of hepatocyte apoptotic process - - - - - Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process. - GOC:TermGenie - GO_REF:0000058 - PMID:8649852 - - - - - regulation of hepatocyte apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process. - sl - 2015-02-19T12:54:50Z - down regulation of hepatocyte apoptotic process - down-regulation of hepatocyte apoptotic process - downregulation of hepatocyte apoptotic process - down regulation of hepatocyte apoptosis - down-regulation of hepatocyte apoptosis - downregulation of hepatocyte apoptosis - inhibition of hepatocyte apoptosis - inhibition of hepatocyte apoptotic process - negative regulation of hepatocyte apoptosis - biological_process - GO:1903944 - negative regulation of hepatocyte apoptotic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process. - GOC:TermGenie - GO_REF:0000058 - PMID:8649852 - - - - - down regulation of hepatocyte apoptotic process - GOC:TermGenie - - - - - down-regulation of hepatocyte apoptotic process - GOC:TermGenie - - - - - downregulation of hepatocyte apoptotic process - GOC:TermGenie - - - - - down regulation of hepatocyte apoptosis - GOC:TermGenie - - - - - down-regulation of hepatocyte apoptosis - GOC:TermGenie - - - - - downregulation of hepatocyte apoptosis - GOC:TermGenie - - - - - inhibition of hepatocyte apoptosis - GOC:TermGenie - - - - - inhibition of hepatocyte apoptotic process - GOC:TermGenie - - - - - negative regulation of hepatocyte apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process. - sl - 2015-02-19T12:54:59Z - up regulation of hepatocyte apoptotic process - up-regulation of hepatocyte apoptotic process - upregulation of hepatocyte apoptotic process - activation of hepatocyte apoptosis - activation of hepatocyte apoptotic process - positive regulation of hepatocyte apoptosis - up regulation of hepatocyte apoptosis - up-regulation of hepatocyte apoptosis - upregulation of hepatocyte apoptosis - biological_process - GO:1903945 - positive regulation of hepatocyte apoptotic process - - - - - Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process. - GOC:TermGenie - GO_REF:0000058 - PMID:8649852 - - - - - up regulation of hepatocyte apoptotic process - GOC:TermGenie - - - - - up-regulation of hepatocyte apoptotic process - GOC:TermGenie - - - - - upregulation of hepatocyte apoptotic process - GOC:TermGenie - - - - - activation of hepatocyte apoptosis - GOC:TermGenie - - - - - activation of hepatocyte apoptotic process - GOC:TermGenie - - - - - positive regulation of hepatocyte apoptosis - GOC:TermGenie - - - - - up regulation of hepatocyte apoptosis - GOC:TermGenie - - - - - up-regulation of hepatocyte apoptosis - GOC:TermGenie - - - - - upregulation of hepatocyte apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential. - nc - 2015-02-20T14:59:41Z - down regulation of AV node cardiac muscle cell action potential - down regulation of AV node cell action potential - down regulation of atrioventricular node cardiac muscle cell action potential - down-regulation of AV node cardiac muscle cell action potential - down-regulation of AV node cell action potential - down-regulation of atrioventricular node cardiac muscle cell action potential - downregulation of AV node cardiac muscle cell action potential - downregulation of AV node cell action potential - downregulation of atrioventricular node cardiac muscle cell action potential - negative regulation of AV node cardiac muscle cell action potential - negative regulation of atrioventricular node cardiac muscle cell action potential - inhibition of AV node cardiac muscle cell action potential - inhibition of AV node cell action potential - inhibition of atrioventricular node cardiac muscle cell action potential - biological_process - GO:1903950 - negative regulation of AV node cell action potential - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential. - GOC:BHF - GOC:TermGenie - GOC:mtg_cardiac_conduct_nov11 - GOC:nc - GO_REF:0000058 - PMID:25281747 - - - - - down regulation of AV node cardiac muscle cell action potential - GOC:TermGenie - - - - - down regulation of AV node cell action potential - GOC:TermGenie - - - - - down regulation of atrioventricular node cardiac muscle cell action potential - GOC:TermGenie - - - - - down-regulation of AV node cardiac muscle cell action potential - GOC:TermGenie - - - - - down-regulation of AV node cell action potential - GOC:TermGenie - - - - - down-regulation of atrioventricular node cardiac muscle cell action potential - GOC:TermGenie - - - - - downregulation of AV node cardiac muscle cell action potential - GOC:TermGenie - - - - - downregulation of AV node cell action potential - GOC:TermGenie - - - - - downregulation of atrioventricular node cardiac muscle cell action potential - GOC:TermGenie - - - - - negative regulation of AV node cardiac muscle cell action potential - GOC:TermGenie - - - - - negative regulation of atrioventricular node cardiac muscle cell action potential - GOC:TermGenie - - - - - inhibition of AV node cardiac muscle cell action potential - GOC:TermGenie - - - - - inhibition of AV node cell action potential - GOC:TermGenie - - - - - inhibition of atrioventricular node cardiac muscle cell action potential - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of AV node cell action potential. - nc - 2015-02-20T14:59:50Z - positive regulation of AV node cardiac muscle cell action potential - positive regulation of atrioventricular node cardiac muscle cell action potential - up regulation of AV node cardiac muscle cell action potential - up regulation of AV node cell action potential - up regulation of atrioventricular node cardiac muscle cell action potential - up-regulation of AV node cardiac muscle cell action potential - up-regulation of AV node cell action potential - up-regulation of atrioventricular node cardiac muscle cell action potential - upregulation of AV node cardiac muscle cell action potential - upregulation of AV node cell action potential - upregulation of atrioventricular node cardiac muscle cell action potential - activation of AV node cardiac muscle cell action potential - activation of AV node cell action potential - activation of atrioventricular node cardiac muscle cell action potential - biological_process - GO:1903951 - positive regulation of AV node cell action potential - - - - - Any process that activates or increases the frequency, rate or extent of AV node cell action potential. - GOC:BHF - GOC:TermGenie - GOC:mtg_cardiac_conduct_nov11 - GOC:nc - GO_REF:0000058 - PMID:25281747 - - - - - positive regulation of AV node cardiac muscle cell action potential - GOC:TermGenie - - - - - positive regulation of atrioventricular node cardiac muscle cell action potential - GOC:TermGenie - - - - - up regulation of AV node cardiac muscle cell action potential - GOC:TermGenie - - - - - up regulation of AV node cell action potential - GOC:TermGenie - - - - - up regulation of atrioventricular node cardiac muscle cell action potential - GOC:TermGenie - - - - - up-regulation of AV node cardiac muscle cell action potential - GOC:TermGenie - - - - - up-regulation of AV node cell action potential - GOC:TermGenie - - - - - up-regulation of atrioventricular node cardiac muscle cell action potential - GOC:TermGenie - - - - - upregulation of AV node cardiac muscle cell action potential - GOC:TermGenie - - - - - upregulation of AV node cell action potential - GOC:TermGenie - - - - - upregulation of atrioventricular node cardiac muscle cell action potential - GOC:TermGenie - - - - - activation of AV node cardiac muscle cell action potential - GOC:TermGenie - - - - - activation of AV node cell action potential - GOC:TermGenie - - - - - activation of atrioventricular node cardiac muscle cell action potential - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus. - sl - 2015-03-06T19:33:54Z - biological_process - GO:1904014 - response to serotonin - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus. - GOC:TermGenie - GO_REF:0000071 - PMID:1505525 - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of vasculature development. - sl - 2015-03-06T22:17:04Z - up regulation of vasculature development - up-regulation of vasculature development - upregulation of vasculature development - activation of vasculature development - biological_process - activation of vascular system development - positive regulation of vascular system development - up regulation of vascular system development - up-regulation of vascular system development - upregulation of vascular system development - GO:1904018 - positive regulation of vasculature development - - - - - Any process that activates or increases the frequency, rate or extent of vasculature development. - GOC:TermGenie - GO_REF:0000058 - PMID:21472453 - - - - - up regulation of vasculature development - GOC:TermGenie - - - - - up-regulation of vasculature development - GOC:TermGenie - - - - - upregulation of vasculature development - GOC:TermGenie - - - - - activation of vasculature development - GOC:TermGenie - - - - - activation of vascular system development - GOC:TermGenie - - - - - positive regulation of vascular system development - GOC:TermGenie - - - - - up regulation of vascular system development - GOC:TermGenie - - - - - up-regulation of vascular system development - GOC:TermGenie - - - - - upregulation of vascular system development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in an epithelial cell. - - sl - 2015-03-06T22:27:17Z - epitheliocyte apoptotic process - epithelial cell apoptosis - epitheliocyte apoptosis - biological_process - GO:1904019 - epithelial cell apoptotic process - - - - - Any apoptotic process in an epithelial cell. - GOC:TermGenie - GO_REF:0000085 - PMID:19137015 - - - - - epitheliocyte apoptotic process - GOC:TermGenie - - - - - epithelial cell apoptosis - GOC:TermGenie - - - - - epitheliocyte apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of collagen fibril organization. - ae - 2015-03-12T12:36:52Z - regulation of collagen fibril organisation - regulation of fibrillar collagen organization - biological_process - regulation of collagen fibrillogenesis - GO:1904026 - regulation of collagen fibril organization - - - - - Any process that modulates the frequency, rate or extent of collagen fibril organization. - GOC:TermGenie - GO_REF:0000058 - PMID:25451920 - - - - - regulation of collagen fibril organisation - GOC:TermGenie - - - - - regulation of fibrillar collagen organization - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization. - ae - 2015-03-12T12:36:59Z - down regulation of collagen fibril organisation - down regulation of collagen fibril organization - down regulation of fibrillar collagen organization - down-regulation of collagen fibril organisation - down-regulation of collagen fibril organization - down-regulation of fibrillar collagen organization - downregulation of collagen fibril organisation - downregulation of collagen fibril organization - downregulation of fibrillar collagen organization - negative regulation of collagen fibril organisation - negative regulation of fibrillar collagen organization - inhibition of collagen fibril organisation - inhibition of collagen fibril organization - inhibition of fibrillar collagen organization - biological_process - GO:1904027 - negative regulation of collagen fibril organization - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization. - GOC:TermGenie - GO_REF:0000058 - PMID:25451920 - - - - - down regulation of collagen fibril organisation - GOC:TermGenie - - - - - down regulation of collagen fibril organization - GOC:TermGenie - - - - - down regulation of fibrillar collagen organization - GOC:TermGenie - - - - - down-regulation of collagen fibril organisation - GOC:TermGenie - - - - - down-regulation of collagen fibril organization - GOC:TermGenie - - - - - down-regulation of fibrillar collagen organization - GOC:TermGenie - - - - - downregulation of collagen fibril organisation - GOC:TermGenie - - - - - downregulation of collagen fibril organization - GOC:TermGenie - - - - - downregulation of fibrillar collagen organization - GOC:TermGenie - - - - - negative regulation of collagen fibril organisation - GOC:TermGenie - - - - - negative regulation of fibrillar collagen organization - GOC:TermGenie - - - - - inhibition of collagen fibril organisation - GOC:TermGenie - - - - - inhibition of collagen fibril organization - GOC:TermGenie - - - - - inhibition of fibrillar collagen organization - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of collagen fibril organization. - ae - 2015-03-12T12:37:06Z - positive regulation of collagen fibril organisation - positive regulation of fibrillar collagen organization - up regulation of collagen fibril organisation - up regulation of collagen fibril organization - up regulation of fibrillar collagen organization - up-regulation of collagen fibril organisation - up-regulation of collagen fibril organization - up-regulation of fibrillar collagen organization - upregulation of collagen fibril organisation - upregulation of collagen fibril organization - upregulation of fibrillar collagen organization - activation of collagen fibril organisation - activation of collagen fibril organization - activation of fibrillar collagen organization - biological_process - GO:1904028 - positive regulation of collagen fibril organization - - - - - Any process that activates or increases the frequency, rate or extent of collagen fibril organization. - GOC:TermGenie - GO_REF:0000058 - PMID:25451920 - - - - - positive regulation of collagen fibril organisation - GOC:TermGenie - - - - - positive regulation of fibrillar collagen organization - GOC:TermGenie - - - - - up regulation of collagen fibril organisation - GOC:TermGenie - - - - - up regulation of collagen fibril organization - GOC:TermGenie - - - - - up regulation of fibrillar collagen organization - GOC:TermGenie - - - - - up-regulation of collagen fibril organisation - GOC:TermGenie - - - - - up-regulation of collagen fibril organization - GOC:TermGenie - - - - - up-regulation of fibrillar collagen organization - GOC:TermGenie - - - - - upregulation of collagen fibril organisation - GOC:TermGenie - - - - - upregulation of collagen fibril organization - GOC:TermGenie - - - - - upregulation of fibrillar collagen organization - GOC:TermGenie - - - - - activation of collagen fibril organisation - GOC:TermGenie - - - - - activation of collagen fibril organization - GOC:TermGenie - - - - - activation of fibrillar collagen organization - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. - sl - 2015-03-13T22:05:41Z - regulation of epitheliocyte apoptotic process - regulation of epithelial cell apoptosis - regulation of epitheliocyte apoptosis - biological_process - GO:1904035 - regulation of epithelial cell apoptotic process - - - - - Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. - GOC:TermGenie - GO_REF:0000058 - PMID:19137015 - - - - - regulation of epitheliocyte apoptotic process - GOC:TermGenie - - - - - regulation of epithelial cell apoptosis - GOC:TermGenie - - - - - regulation of epitheliocyte apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. - sl - 2015-03-13T22:05:47Z - down regulation of epithelial cell apoptotic process - down regulation of epitheliocyte apoptotic process - down-regulation of epithelial cell apoptotic process - down-regulation of epitheliocyte apoptotic process - downregulation of epithelial cell apoptotic process - downregulation of epitheliocyte apoptotic process - negative regulation of epitheliocyte apoptotic process - down regulation of epithelial cell apoptosis - down regulation of epitheliocyte apoptosis - down-regulation of epithelial cell apoptosis - down-regulation of epitheliocyte apoptosis - downregulation of epithelial cell apoptosis - downregulation of epitheliocyte apoptosis - inhibition of epithelial cell apoptosis - inhibition of epithelial cell apoptotic process - inhibition of epitheliocyte apoptosis - inhibition of epitheliocyte apoptotic process - negative regulation of epithelial cell apoptosis - negative regulation of epitheliocyte apoptosis - biological_process - GO:1904036 - negative regulation of epithelial cell apoptotic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. - GOC:TermGenie - GO_REF:0000058 - PMID:19137015 - - - - - down regulation of epithelial cell apoptotic process - GOC:TermGenie - - - - - down regulation of epitheliocyte apoptotic process - GOC:TermGenie - - - - - down-regulation of epithelial cell apoptotic process - GOC:TermGenie - - - - - down-regulation of epitheliocyte apoptotic process - GOC:TermGenie - - - - - downregulation of epithelial cell apoptotic process - GOC:TermGenie - - - - - downregulation of epitheliocyte apoptotic process - GOC:TermGenie - - - - - negative regulation of epitheliocyte apoptotic process - GOC:TermGenie - - - - - down regulation of epithelial cell apoptosis - GOC:TermGenie - - - - - down regulation of epitheliocyte apoptosis - GOC:TermGenie - - - - - down-regulation of epithelial cell apoptosis - GOC:TermGenie - - - - - down-regulation of epitheliocyte apoptosis - GOC:TermGenie - - - - - downregulation of epithelial cell apoptosis - GOC:TermGenie - - - - - downregulation of epitheliocyte apoptosis - GOC:TermGenie - - - - - inhibition of epithelial cell apoptosis - GOC:TermGenie - - - - - inhibition of epithelial cell apoptotic process - GOC:TermGenie - - - - - inhibition of epitheliocyte apoptosis - GOC:TermGenie - - - - - inhibition of epitheliocyte apoptotic process - GOC:TermGenie - - - - - negative regulation of epithelial cell apoptosis - GOC:TermGenie - - - - - negative regulation of epitheliocyte apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. - sl - 2015-03-13T22:05:53Z - positive regulation of epitheliocyte apoptotic process - up regulation of epithelial cell apoptotic process - up regulation of epitheliocyte apoptotic process - up-regulation of epithelial cell apoptotic process - up-regulation of epitheliocyte apoptotic process - upregulation of epithelial cell apoptotic process - upregulation of epitheliocyte apoptotic process - activation of epithelial cell apoptosis - activation of epithelial cell apoptotic process - activation of epitheliocyte apoptosis - activation of epitheliocyte apoptotic process - positive regulation of epithelial cell apoptosis - positive regulation of epitheliocyte apoptosis - up regulation of epithelial cell apoptosis - up regulation of epitheliocyte apoptosis - up-regulation of epithelial cell apoptosis - up-regulation of epitheliocyte apoptosis - upregulation of epithelial cell apoptosis - upregulation of epitheliocyte apoptosis - biological_process - GO:1904037 - positive regulation of epithelial cell apoptotic process - - - - - Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. - GOC:TermGenie - GO_REF:0000058 - PMID:19137015 - - - - - positive regulation of epitheliocyte apoptotic process - GOC:TermGenie - - - - - up regulation of epithelial cell apoptotic process - GOC:TermGenie - - - - - up regulation of epitheliocyte apoptotic process - GOC:TermGenie - - - - - up-regulation of epithelial cell apoptotic process - GOC:TermGenie - - - - - up-regulation of epitheliocyte apoptotic process - GOC:TermGenie - - - - - upregulation of epithelial cell apoptotic process - GOC:TermGenie - - - - - upregulation of epitheliocyte apoptotic process - GOC:TermGenie - - - - - activation of epithelial cell apoptosis - GOC:TermGenie - - - - - activation of epithelial cell apoptotic process - GOC:TermGenie - - - - - activation of epitheliocyte apoptosis - GOC:TermGenie - - - - - activation of epitheliocyte apoptotic process - GOC:TermGenie - - - - - positive regulation of epithelial cell apoptosis - GOC:TermGenie - - - - - positive regulation of epitheliocyte apoptosis - GOC:TermGenie - - - - - up regulation of epithelial cell apoptosis - GOC:TermGenie - - - - - up regulation of epitheliocyte apoptosis - GOC:TermGenie - - - - - up-regulation of epithelial cell apoptosis - GOC:TermGenie - - - - - up-regulation of epitheliocyte apoptosis - GOC:TermGenie - - - - - upregulation of epithelial cell apoptosis - GOC:TermGenie - - - - - upregulation of epitheliocyte apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cholangiocyte proliferation. - sl - 2015-03-18T17:56:14Z - regulation of hepatoblast proliferation - biological_process - GO:1904054 - regulation of cholangiocyte proliferation - - - - - Any process that modulates the frequency, rate or extent of cholangiocyte proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:24434010 - - - - - regulation of hepatoblast proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation. - sl - 2015-03-18T17:56:20Z - down regulation of cholangiocyte proliferation - down regulation of hepatoblast proliferation - down-regulation of cholangiocyte proliferation - down-regulation of hepatoblast proliferation - downregulation of cholangiocyte proliferation - downregulation of hepatoblast proliferation - negative regulation of hepatoblast proliferation - inhibition of cholangiocyte proliferation - inhibition of hepatoblast proliferation - biological_process - GO:1904055 - negative regulation of cholangiocyte proliferation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:24434010 - - - - - down regulation of cholangiocyte proliferation - GOC:TermGenie - - - - - down regulation of hepatoblast proliferation - GOC:TermGenie - - - - - down-regulation of cholangiocyte proliferation - GOC:TermGenie - - - - - down-regulation of hepatoblast proliferation - GOC:TermGenie - - - - - downregulation of cholangiocyte proliferation - GOC:TermGenie - - - - - downregulation of hepatoblast proliferation - GOC:TermGenie - - - - - negative regulation of hepatoblast proliferation - GOC:TermGenie - - - - - inhibition of cholangiocyte proliferation - GOC:TermGenie - - - - - inhibition of hepatoblast proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation. - sl - 2015-03-18T17:56:26Z - positive regulation of hepatoblast proliferation - up regulation of cholangiocyte proliferation - up regulation of hepatoblast proliferation - up-regulation of cholangiocyte proliferation - up-regulation of hepatoblast proliferation - upregulation of cholangiocyte proliferation - upregulation of hepatoblast proliferation - activation of cholangiocyte proliferation - activation of hepatoblast proliferation - biological_process - GO:1904056 - positive regulation of cholangiocyte proliferation - - - - - Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:24434010 - - - - - positive regulation of hepatoblast proliferation - GOC:TermGenie - - - - - up regulation of cholangiocyte proliferation - GOC:TermGenie - - - - - up regulation of hepatoblast proliferation - GOC:TermGenie - - - - - up-regulation of cholangiocyte proliferation - GOC:TermGenie - - - - - up-regulation of hepatoblast proliferation - GOC:TermGenie - - - - - upregulation of cholangiocyte proliferation - GOC:TermGenie - - - - - upregulation of hepatoblast proliferation - GOC:TermGenie - - - - - activation of cholangiocyte proliferation - GOC:TermGenie - - - - - activation of hepatoblast proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain. - sl - 2015-03-18T20:33:57Z - down regulation of nociception - down regulation of sensory perception of pain - down-regulation of nociception - down-regulation of sensory perception of pain - downregulation of nociception - downregulation of sensory perception of pain - negative regulation of nociception - down regulation of perception of physiological pain - down-regulation of perception of physiological pain - downregulation of perception of physiological pain - inhibition of nociception - inhibition of perception of physiological pain - inhibition of sensory perception of pain - negative regulation of perception of physiological pain - biological_process - GO:1904057 - negative regulation of sensory perception of pain - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain. - GOC:TermGenie - GO_REF:0000058 - PMID:17167094 - - - - - down regulation of nociception - GOC:TermGenie - - - - - down regulation of sensory perception of pain - GOC:TermGenie - - - - - down-regulation of nociception - GOC:TermGenie - - - - - down-regulation of sensory perception of pain - GOC:TermGenie - - - - - downregulation of nociception - GOC:TermGenie - - - - - downregulation of sensory perception of pain - GOC:TermGenie - - - - - negative regulation of nociception - GOC:TermGenie - - - - - down regulation of perception of physiological pain - GOC:TermGenie - - - - - down-regulation of perception of physiological pain - GOC:TermGenie - - - - - downregulation of perception of physiological pain - GOC:TermGenie - - - - - inhibition of nociception - GOC:TermGenie - - - - - inhibition of perception of physiological pain - GOC:TermGenie - - - - - inhibition of sensory perception of pain - GOC:TermGenie - - - - - negative regulation of perception of physiological pain - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of sensory perception of pain. - sl - 2015-03-18T20:34:03Z - positive regulation of nociception - up regulation of nociception - up regulation of sensory perception of pain - up-regulation of nociception - up-regulation of sensory perception of pain - upregulation of nociception - upregulation of sensory perception of pain - activation of nociception - activation of perception of physiological pain - activation of sensory perception of pain - positive regulation of perception of physiological pain - up regulation of perception of physiological pain - up-regulation of perception of physiological pain - upregulation of perception of physiological pain - biological_process - GO:1904058 - positive regulation of sensory perception of pain - - - - - Any process that activates or increases the frequency, rate or extent of sensory perception of pain. - GOC:TermGenie - GO_REF:0000058 - PMID:17167094 - - - - - positive regulation of nociception - GOC:TermGenie - - - - - up regulation of nociception - GOC:TermGenie - - - - - up regulation of sensory perception of pain - GOC:TermGenie - - - - - up-regulation of nociception - GOC:TermGenie - - - - - up-regulation of sensory perception of pain - GOC:TermGenie - - - - - upregulation of nociception - GOC:TermGenie - - - - - upregulation of sensory perception of pain - GOC:TermGenie - - - - - activation of nociception - GOC:TermGenie - - - - - activation of perception of physiological pain - GOC:TermGenie - - - - - activation of sensory perception of pain - GOC:TermGenie - - - - - positive regulation of perception of physiological pain - GOC:TermGenie - - - - - up regulation of perception of physiological pain - GOC:TermGenie - - - - - up-regulation of perception of physiological pain - GOC:TermGenie - - - - - upregulation of perception of physiological pain - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cation transmembrane transport. - sl - 2015-03-18T21:11:43Z - regulation of cation transmembrane transport - biological_process - GO:1904062 - regulation of monoatomic cation transmembrane transport - - - - - Any process that modulates the frequency, rate or extent of cation transmembrane transport. - GOC:TermGenie - GO_REF:0000058 - PMID:15304482 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport. - sl - 2015-03-18T21:11:50Z - down regulation of cation transmembrane transport - down-regulation of cation transmembrane transport - downregulation of cation transmembrane transport - inhibition of cation transmembrane transport - biological_process - GO:1904063 - negative regulation of cation transmembrane transport - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport. - GOC:TermGenie - GO_REF:0000058 - PMID:15304482 - - - - - down regulation of cation transmembrane transport - GOC:TermGenie - - - - - down-regulation of cation transmembrane transport - GOC:TermGenie - - - - - downregulation of cation transmembrane transport - GOC:TermGenie - - - - - inhibition of cation transmembrane transport - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cation transmembrane transport. - sl - 2015-03-18T21:11:55Z - up regulation of cation transmembrane transport - up-regulation of cation transmembrane transport - upregulation of cation transmembrane transport - activation of cation transmembrane transport - biological_process - GO:1904064 - positive regulation of cation transmembrane transport - - - - - Any process that activates or increases the frequency, rate or extent of cation transmembrane transport. - GOC:TermGenie - GO_REF:0000058 - PMID:15304482 - - - - - up regulation of cation transmembrane transport - GOC:TermGenie - - - - - up-regulation of cation transmembrane transport - GOC:TermGenie - - - - - upregulation of cation transmembrane transport - GOC:TermGenie - - - - - activation of cation transmembrane transport - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation. - tb - 2015-03-20T16:55:56Z - regulation of trophectoderm cell proliferation - biological_process - GO:1904073 - regulation of trophectodermal cell proliferation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:24508636 - - - - - regulation of trophectoderm cell proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation. - tb - 2015-03-20T16:56:02Z - down regulation of trophectoderm cell proliferation - down regulation of trophectodermal cell proliferation - down-regulation of trophectoderm cell proliferation - down-regulation of trophectodermal cell proliferation - downregulation of trophectoderm cell proliferation - downregulation of trophectodermal cell proliferation - negative regulation of trophectoderm cell proliferation - inhibition of trophectoderm cell proliferation - inhibition of trophectodermal cell proliferation - biological_process - GO:1904074 - negative regulation of trophectodermal cell proliferation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:24508636 - - - - - down regulation of trophectoderm cell proliferation - GOC:TermGenie - - - - - down regulation of trophectodermal cell proliferation - GOC:TermGenie - - - - - down-regulation of trophectoderm cell proliferation - GOC:TermGenie - - - - - down-regulation of trophectodermal cell proliferation - GOC:TermGenie - - - - - downregulation of trophectoderm cell proliferation - GOC:TermGenie - - - - - downregulation of trophectodermal cell proliferation - GOC:TermGenie - - - - - negative regulation of trophectoderm cell proliferation - GOC:TermGenie - - - - - inhibition of trophectoderm cell proliferation - GOC:TermGenie - - - - - inhibition of trophectodermal cell proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation. - tb - 2015-03-20T16:56:08Z - positive regulation of trophectoderm cell proliferation - up regulation of trophectoderm cell proliferation - up regulation of trophectodermal cell proliferation - up-regulation of trophectoderm cell proliferation - up-regulation of trophectodermal cell proliferation - upregulation of trophectoderm cell proliferation - upregulation of trophectodermal cell proliferation - activation of trophectoderm cell proliferation - activation of trophectodermal cell proliferation - biological_process - GO:1904075 - positive regulation of trophectodermal cell proliferation - - - - - Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:24508636 - - - - - positive regulation of trophectoderm cell proliferation - GOC:TermGenie - - - - - up regulation of trophectoderm cell proliferation - GOC:TermGenie - - - - - up regulation of trophectodermal cell proliferation - GOC:TermGenie - - - - - up-regulation of trophectoderm cell proliferation - GOC:TermGenie - - - - - up-regulation of trophectodermal cell proliferation - GOC:TermGenie - - - - - upregulation of trophectoderm cell proliferation - GOC:TermGenie - - - - - upregulation of trophectodermal cell proliferation - GOC:TermGenie - - - - - activation of trophectoderm cell proliferation - GOC:TermGenie - - - - - activation of trophectodermal cell proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, a location within a microvillus. - kmv - 2015-04-01T18:14:41Z - protein localisation in microvillus - protein localisation to microvillus - protein localization in microvillus - biological_process - GO:1904106 - protein localization to microvillus - - - - - A process in which a protein is transported to, or maintained in, a location within a microvillus. - GOC:TermGenie - GOC:kmv - GO_REF:0000087 - PMID:25335890 - - - - - protein localisation in microvillus - GOC:TermGenie - - - - - protein localisation to microvillus - GOC:TermGenie - - - - - protein localization in microvillus - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. - tb - 2015-04-14T15:59:22Z - down regulation of meiotic cell cycle process involved in oocyte maturation - down-regulation of meiotic cell cycle process involved in oocyte maturation - downregulation of meiotic cell cycle process involved in oocyte maturation - inhibition of meiotic cell cycle process involved in oocyte maturation - biological_process - GO:1904145 - negative regulation of meiotic cell cycle process involved in oocyte maturation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. - GOC:TermGenie - GO_REF:0000058 - PMID:22674394 - - - - - down regulation of meiotic cell cycle process involved in oocyte maturation - GOC:TermGenie - - - - - down-regulation of meiotic cell cycle process involved in oocyte maturation - GOC:TermGenie - - - - - downregulation of meiotic cell cycle process involved in oocyte maturation - GOC:TermGenie - - - - - inhibition of meiotic cell cycle process involved in oocyte maturation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. - tb - 2015-04-14T15:59:28Z - up regulation of meiotic cell cycle process involved in oocyte maturation - up-regulation of meiotic cell cycle process involved in oocyte maturation - upregulation of meiotic cell cycle process involved in oocyte maturation - activation of meiotic cell cycle process involved in oocyte maturation - biological_process - GO:1904146 - positive regulation of meiotic cell cycle process involved in oocyte maturation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. - GOC:TermGenie - GO_REF:0000058 - PMID:22674394 - - - - - up regulation of meiotic cell cycle process involved in oocyte maturation - GOC:TermGenie - - - - - up-regulation of meiotic cell cycle process involved in oocyte maturation - GOC:TermGenie - - - - - upregulation of meiotic cell cycle process involved in oocyte maturation - GOC:TermGenie - - - - - activation of meiotic cell cycle process involved in oocyte maturation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of bleb assembly. - als - 2015-04-23T09:32:19Z - regulation of cell blebbing - biological_process - GO:1904170 - regulation of bleb assembly - - - - - Any process that modulates the frequency, rate or extent of bleb assembly. - GOC:TermGenie - GOC:als - GO_REF:0000058 - PMID:25651887 - - - - - regulation of cell blebbing - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly. - als - 2015-04-23T09:32:25Z - down regulation of bleb assembly - down regulation of cell blebbing - down-regulation of bleb assembly - down-regulation of cell blebbing - downregulation of bleb assembly - downregulation of cell blebbing - negative regulation of cell blebbing - inhibition of bleb assembly - inhibition of cell blebbing - biological_process - GO:1904171 - negative regulation of bleb assembly - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly. - GOC:TermGenie - GOC:als - GO_REF:0000058 - PMID:25651887 - - - - - down regulation of bleb assembly - GOC:TermGenie - - - - - down regulation of cell blebbing - GOC:TermGenie - - - - - down-regulation of bleb assembly - GOC:TermGenie - - - - - down-regulation of cell blebbing - GOC:TermGenie - - - - - downregulation of bleb assembly - GOC:TermGenie - - - - - downregulation of cell blebbing - GOC:TermGenie - - - - - negative regulation of cell blebbing - GOC:TermGenie - - - - - inhibition of bleb assembly - GOC:TermGenie - - - - - inhibition of cell blebbing - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of bleb assembly. - als - 2015-04-23T09:32:31Z - positive regulation of cell blebbing - up regulation of bleb assembly - up regulation of cell blebbing - up-regulation of bleb assembly - up-regulation of cell blebbing - upregulation of bleb assembly - upregulation of cell blebbing - activation of bleb assembly - activation of cell blebbing - biological_process - GO:1904172 - positive regulation of bleb assembly - - - - - Any process that activates or increases the frequency, rate or extent of bleb assembly. - GOC:TermGenie - GOC:als - GO_REF:0000058 - PMID:25651887 - - - - - positive regulation of cell blebbing - GOC:TermGenie - - - - - up regulation of bleb assembly - GOC:TermGenie - - - - - up regulation of cell blebbing - GOC:TermGenie - - - - - up-regulation of bleb assembly - GOC:TermGenie - - - - - up-regulation of cell blebbing - GOC:TermGenie - - - - - upregulation of bleb assembly - GOC:TermGenie - - - - - upregulation of cell blebbing - GOC:TermGenie - - - - - activation of bleb assembly - GOC:TermGenie - - - - - activation of cell blebbing - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of adipose tissue development. - sl - 2015-04-29T20:01:01Z - biological_process - regulation of adipogenesis - GO:1904177 - regulation of adipose tissue development - - - - - Any process that modulates the frequency, rate or extent of adipose tissue development. - GOC:TermGenie - GO_REF:0000058 - PMID:23081848 - - - - - regulation of adipogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development. - sl - 2015-04-29T20:01:07Z - down regulation of adipose tissue development - down-regulation of adipose tissue development - downregulation of adipose tissue development - inhibition of adipose tissue development - biological_process - down regulation of adipogenesis - down-regulation of adipogenesis - downregulation of adipogenesis - inhibition of adipogenesis - negative regulation of adipogenesis - GO:1904178 - negative regulation of adipose tissue development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development. - GOC:TermGenie - GO_REF:0000058 - PMID:23081848 - - - - - down regulation of adipose tissue development - GOC:TermGenie - - - - - down-regulation of adipose tissue development - GOC:TermGenie - - - - - downregulation of adipose tissue development - GOC:TermGenie - - - - - inhibition of adipose tissue development - GOC:TermGenie - - - - - down regulation of adipogenesis - GOC:TermGenie - - - - - down-regulation of adipogenesis - GOC:TermGenie - - - - - downregulation of adipogenesis - GOC:TermGenie - - - - - inhibition of adipogenesis - GOC:TermGenie - - - - - negative regulation of adipogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of adipose tissue development. - sl - 2015-04-29T20:01:13Z - up regulation of adipose tissue development - up-regulation of adipose tissue development - upregulation of adipose tissue development - activation of adipose tissue development - biological_process - activation of adipogenesis - positive regulation of adipogenesis - up regulation of adipogenesis - up-regulation of adipogenesis - upregulation of adipogenesis - GO:1904179 - positive regulation of adipose tissue development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of adipose tissue development. - GOC:TermGenie - GO_REF:0000058 - PMID:23081848 - - - - - up regulation of adipose tissue development - GOC:TermGenie - - - - - up-regulation of adipose tissue development - GOC:TermGenie - - - - - upregulation of adipose tissue development - GOC:TermGenie - - - - - activation of adipose tissue development - GOC:TermGenie - - - - - activation of adipogenesis - GOC:TermGenie - - - - - positive regulation of adipogenesis - GOC:TermGenie - - - - - up regulation of adipogenesis - GOC:TermGenie - - - - - up-regulation of adipogenesis - GOC:TermGenie - - - - - upregulation of adipogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process. - sl - 2015-05-06T15:25:48Z - regulation of epithelial cell of bile duct apoptotic process - regulation of cholangiocyte apoptosis - regulation of epithelial cell of bile duct apoptosis - biological_process - GO:1904192 - regulation of cholangiocyte apoptotic process - - - - - Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process. - GOC:TermGenie - GO_REF:0000058 - PMID:24498161 - - - - - regulation of epithelial cell of bile duct apoptotic process - GOC:TermGenie - - - - - regulation of cholangiocyte apoptosis - GOC:TermGenie - - - - - regulation of epithelial cell of bile duct apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process. - sl - 2015-05-06T15:25:55Z - down regulation of cholangiocyte apoptotic process - down regulation of epithelial cell of bile duct apoptotic process - down-regulation of cholangiocyte apoptotic process - down-regulation of epithelial cell of bile duct apoptotic process - downregulation of cholangiocyte apoptotic process - downregulation of epithelial cell of bile duct apoptotic process - negative regulation of epithelial cell of bile duct apoptotic process - down regulation of cholangiocyte apoptosis - down regulation of epithelial cell of bile duct apoptosis - down-regulation of cholangiocyte apoptosis - down-regulation of epithelial cell of bile duct apoptosis - downregulation of cholangiocyte apoptosis - downregulation of epithelial cell of bile duct apoptosis - inhibition of cholangiocyte apoptosis - inhibition of cholangiocyte apoptotic process - inhibition of epithelial cell of bile duct apoptosis - inhibition of epithelial cell of bile duct apoptotic process - negative regulation of cholangiocyte apoptosis - negative regulation of epithelial cell of bile duct apoptosis - biological_process - GO:1904193 - negative regulation of cholangiocyte apoptotic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process. - GOC:TermGenie - GO_REF:0000058 - PMID:24498161 - - - - - down regulation of cholangiocyte apoptotic process - GOC:TermGenie - - - - - down regulation of epithelial cell of bile duct apoptotic process - GOC:TermGenie - - - - - down-regulation of cholangiocyte apoptotic process - GOC:TermGenie - - - - - down-regulation of epithelial cell of bile duct apoptotic process - GOC:TermGenie - - - - - downregulation of cholangiocyte apoptotic process - GOC:TermGenie - - - - - downregulation of epithelial cell of bile duct apoptotic process - GOC:TermGenie - - - - - negative regulation of epithelial cell of bile duct apoptotic process - GOC:TermGenie - - - - - down regulation of cholangiocyte apoptosis - GOC:TermGenie - - - - - down regulation of epithelial cell of bile duct apoptosis - GOC:TermGenie - - - - - down-regulation of cholangiocyte apoptosis - GOC:TermGenie - - - - - down-regulation of epithelial cell of bile duct apoptosis - GOC:TermGenie - - - - - downregulation of cholangiocyte apoptosis - GOC:TermGenie - - - - - downregulation of epithelial cell of bile duct apoptosis - GOC:TermGenie - - - - - inhibition of cholangiocyte apoptosis - GOC:TermGenie - - - - - inhibition of cholangiocyte apoptotic process - GOC:TermGenie - - - - - inhibition of epithelial cell of bile duct apoptosis - GOC:TermGenie - - - - - inhibition of epithelial cell of bile duct apoptotic process - GOC:TermGenie - - - - - negative regulation of cholangiocyte apoptosis - GOC:TermGenie - - - - - negative regulation of epithelial cell of bile duct apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process. - sl - 2015-05-06T15:26:00Z - positive regulation of epithelial cell of bile duct apoptotic process - up regulation of cholangiocyte apoptotic process - up regulation of epithelial cell of bile duct apoptotic process - up-regulation of cholangiocyte apoptotic process - up-regulation of epithelial cell of bile duct apoptotic process - upregulation of cholangiocyte apoptotic process - upregulation of epithelial cell of bile duct apoptotic process - activation of cholangiocyte apoptosis - activation of cholangiocyte apoptotic process - activation of epithelial cell of bile duct apoptosis - activation of epithelial cell of bile duct apoptotic process - positive regulation of cholangiocyte apoptosis - positive regulation of epithelial cell of bile duct apoptosis - up regulation of cholangiocyte apoptosis - up regulation of epithelial cell of bile duct apoptosis - up-regulation of cholangiocyte apoptosis - up-regulation of epithelial cell of bile duct apoptosis - upregulation of cholangiocyte apoptosis - upregulation of epithelial cell of bile duct apoptosis - biological_process - GO:1904194 - positive regulation of cholangiocyte apoptotic process - - - - - Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process. - GOC:TermGenie - GO_REF:0000058 - PMID:24498161 - - - - - positive regulation of epithelial cell of bile duct apoptotic process - GOC:TermGenie - - - - - up regulation of cholangiocyte apoptotic process - GOC:TermGenie - - - - - up regulation of epithelial cell of bile duct apoptotic process - GOC:TermGenie - - - - - up-regulation of cholangiocyte apoptotic process - GOC:TermGenie - - - - - up-regulation of epithelial cell of bile duct apoptotic process - GOC:TermGenie - - - - - upregulation of cholangiocyte apoptotic process - GOC:TermGenie - - - - - upregulation of epithelial cell of bile duct apoptotic process - GOC:TermGenie - - - - - activation of cholangiocyte apoptosis - GOC:TermGenie - - - - - activation of cholangiocyte apoptotic process - GOC:TermGenie - - - - - activation of epithelial cell of bile duct apoptosis - GOC:TermGenie - - - - - activation of epithelial cell of bile duct apoptotic process - GOC:TermGenie - - - - - positive regulation of cholangiocyte apoptosis - GOC:TermGenie - - - - - positive regulation of epithelial cell of bile duct apoptosis - GOC:TermGenie - - - - - up regulation of cholangiocyte apoptosis - GOC:TermGenie - - - - - up regulation of epithelial cell of bile duct apoptosis - GOC:TermGenie - - - - - up-regulation of cholangiocyte apoptosis - GOC:TermGenie - - - - - up-regulation of epithelial cell of bile duct apoptosis - GOC:TermGenie - - - - - upregulation of cholangiocyte apoptosis - GOC:TermGenie - - - - - upregulation of epithelial cell of bile duct apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy. - sl - 2015-05-08T17:38:13Z - biological_process - GO:1904204 - regulation of skeletal muscle hypertrophy - - - - - Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy. - GOC:TermGenie - GO_REF:0000058 - PMID:23470307 - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy. - sl - 2015-05-08T17:38:19Z - down regulation of skeletal muscle hypertrophy - down-regulation of skeletal muscle hypertrophy - downregulation of skeletal muscle hypertrophy - inhibition of skeletal muscle hypertrophy - biological_process - GO:1904205 - negative regulation of skeletal muscle hypertrophy - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy. - GOC:TermGenie - GO_REF:0000058 - PMID:23470307 - - - - - down regulation of skeletal muscle hypertrophy - GOC:TermGenie - - - - - down-regulation of skeletal muscle hypertrophy - GOC:TermGenie - - - - - downregulation of skeletal muscle hypertrophy - GOC:TermGenie - - - - - inhibition of skeletal muscle hypertrophy - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy. - sl - 2015-05-08T17:38:25Z - up regulation of skeletal muscle hypertrophy - up-regulation of skeletal muscle hypertrophy - upregulation of skeletal muscle hypertrophy - activation of skeletal muscle hypertrophy - biological_process - GO:1904206 - positive regulation of skeletal muscle hypertrophy - - - - - Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy. - GOC:TermGenie - GO_REF:0000058 - PMID:23470307 - - - - - up regulation of skeletal muscle hypertrophy - GOC:TermGenie - - - - - up-regulation of skeletal muscle hypertrophy - GOC:TermGenie - - - - - upregulation of skeletal muscle hypertrophy - GOC:TermGenie - - - - - activation of skeletal muscle hypertrophy - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of bile acid metabolic process. - bf - 2015-05-20T11:04:28Z - regulation of bile acid metabolism - biological_process - GO:1904251 - regulation of bile acid metabolic process - - - - - Any process that modulates the frequency, rate or extent of bile acid metabolic process. - GOC:TermGenie - GOC:bf - GO_REF:0000058 - - - - - regulation of bile acid metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process. - bf - 2015-05-20T11:04:35Z - down regulation of bile acid metabolic process - down regulation of bile acid metabolism - down-regulation of bile acid metabolic process - down-regulation of bile acid metabolism - downregulation of bile acid metabolic process - downregulation of bile acid metabolism - negative regulation of bile acid metabolism - inhibition of bile acid metabolic process - inhibition of bile acid metabolism - biological_process - GO:1904252 - negative regulation of bile acid metabolic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process. - GOC:TermGenie - GOC:bf - GO_REF:0000058 - - - - - down regulation of bile acid metabolic process - GOC:TermGenie - - - - - down regulation of bile acid metabolism - GOC:TermGenie - - - - - down-regulation of bile acid metabolic process - GOC:TermGenie - - - - - down-regulation of bile acid metabolism - GOC:TermGenie - - - - - downregulation of bile acid metabolic process - GOC:TermGenie - - - - - downregulation of bile acid metabolism - GOC:TermGenie - - - - - negative regulation of bile acid metabolism - GOC:TermGenie - - - - - inhibition of bile acid metabolic process - GOC:TermGenie - - - - - inhibition of bile acid metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of bile acid metabolic process. - bf - 2015-05-20T11:04:40Z - positive regulation of bile acid metabolism - up regulation of bile acid metabolic process - up regulation of bile acid metabolism - up-regulation of bile acid metabolic process - up-regulation of bile acid metabolism - upregulation of bile acid metabolic process - upregulation of bile acid metabolism - activation of bile acid metabolic process - activation of bile acid metabolism - biological_process - GO:1904253 - positive regulation of bile acid metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of bile acid metabolic process. - GOC:TermGenie - GOC:bf - GO_REF:0000058 - - - - - positive regulation of bile acid metabolism - GOC:TermGenie - - - - - up regulation of bile acid metabolic process - GOC:TermGenie - - - - - up regulation of bile acid metabolism - GOC:TermGenie - - - - - up-regulation of bile acid metabolic process - GOC:TermGenie - - - - - up-regulation of bile acid metabolism - GOC:TermGenie - - - - - upregulation of bile acid metabolic process - GOC:TermGenie - - - - - upregulation of bile acid metabolism - GOC:TermGenie - - - - - activation of bile acid metabolic process - GOC:TermGenie - - - - - activation of bile acid metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - The cell cortex of the leading edge of a cell. - kmv - 2015-05-28T19:16:03Z - cell cortex of cell leading edge - cell cortex of front of cell - cell cortex of leading edge of cell - cellular_component - cell periphery of cell leading edge - cell periphery of front of cell - cell periphery of leading edge of cell - peripheral cytoplasm of cell leading edge - peripheral cytoplasm of front of cell - peripheral cytoplasm of leading edge of cell - GO:1904269 - cell leading edge cell cortex - - - - - The cell cortex of the leading edge of a cell. - GOC:TermGenie - GOC:kmv - GO_REF:0000064 - PMID:25843030 - - - - - cell cortex of cell leading edge - GOC:TermGenie - - - - - cell cortex of front of cell - GOC:TermGenie - - - - - cell cortex of leading edge of cell - GOC:TermGenie - - - - - cell periphery of cell leading edge - GOC:TermGenie - - - - - cell periphery of front of cell - GOC:TermGenie - - - - - cell periphery of leading edge of cell - GOC:TermGenie - - - - - peripheral cytoplasm of cell leading edge - GOC:TermGenie - - - - - peripheral cytoplasm of front of cell - GOC:TermGenie - - - - - peripheral cytoplasm of leading edge of cell - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. - sl - 2015-06-09T23:18:42Z - biological_process - GO:1904304 - regulation of gastro-intestinal system smooth muscle contraction - - - - - Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. - GOC:TermGenie - GO_REF:0000058 - PMID:10821044 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. - sl - 2015-06-09T23:18:48Z - down regulation of gastro-intestinal system smooth muscle contraction - down-regulation of gastro-intestinal system smooth muscle contraction - downregulation of gastro-intestinal system smooth muscle contraction - inhibition of gastro-intestinal system smooth muscle contraction - biological_process - GO:1904305 - negative regulation of gastro-intestinal system smooth muscle contraction - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. - GOC:TermGenie - GO_REF:0000058 - PMID:10821044 - - - - - down regulation of gastro-intestinal system smooth muscle contraction - GOC:TermGenie - - - - - down-regulation of gastro-intestinal system smooth muscle contraction - GOC:TermGenie - - - - - downregulation of gastro-intestinal system smooth muscle contraction - GOC:TermGenie - - - - - inhibition of gastro-intestinal system smooth muscle contraction - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. - sl - 2015-06-09T23:18:54Z - up regulation of gastro-intestinal system smooth muscle contraction - up-regulation of gastro-intestinal system smooth muscle contraction - upregulation of gastro-intestinal system smooth muscle contraction - activation of gastro-intestinal system smooth muscle contraction - biological_process - GO:1904306 - positive regulation of gastro-intestinal system smooth muscle contraction - - - - - Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. - GOC:TermGenie - GO_REF:0000058 - PMID:10821044 - - - - - up regulation of gastro-intestinal system smooth muscle contraction - GOC:TermGenie - - - - - up-regulation of gastro-intestinal system smooth muscle contraction - GOC:TermGenie - - - - - upregulation of gastro-intestinal system smooth muscle contraction - GOC:TermGenie - - - - - activation of gastro-intestinal system smooth muscle contraction - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of colon smooth muscle contraction. - sl - 2015-06-11T21:16:58Z - biological_process - GO:1904341 - regulation of colon smooth muscle contraction - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of colon smooth muscle contraction. - GOC:TermGenie - GO_REF:0000058 - PMID:24170253 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction. - sl - 2015-06-11T21:17:05Z - down regulation of colon smooth muscle contraction - down-regulation of colon smooth muscle contraction - downregulation of colon smooth muscle contraction - inhibition of colon smooth muscle contraction - biological_process - GO:1904342 - negative regulation of colon smooth muscle contraction - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction. - GOC:TermGenie - GO_REF:0000058 - PMID:24170253 - - - - - down regulation of colon smooth muscle contraction - GOC:TermGenie - - - - - down-regulation of colon smooth muscle contraction - GOC:TermGenie - - - - - downregulation of colon smooth muscle contraction - GOC:TermGenie - - - - - inhibition of colon smooth muscle contraction - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction. - sl - 2015-06-11T21:17:11Z - up regulation of colon smooth muscle contraction - up-regulation of colon smooth muscle contraction - upregulation of colon smooth muscle contraction - activation of colon smooth muscle contraction - biological_process - GO:1904343 - positive regulation of colon smooth muscle contraction - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction. - GOC:TermGenie - GO_REF:0000058 - PMID:24170253 - - - - - up regulation of colon smooth muscle contraction - GOC:TermGenie - - - - - up-regulation of colon smooth muscle contraction - GOC:TermGenie - - - - - upregulation of colon smooth muscle contraction - GOC:TermGenie - - - - - activation of colon smooth muscle contraction - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation. - sl - 2015-06-11T21:20:31Z - regulation of stomach mucosal blood circulation - biological_process - GO:1904344 - regulation of gastric mucosal blood circulation - - - - - Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation. - GOC:TermGenie - GO_REF:0000058 - PMID:10807413 - - - - - regulation of stomach mucosal blood circulation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation. - sl - 2015-06-11T21:20:44Z - down regulation of gastric mucosal blood circulation - down regulation of stomach mucosal blood circulation - down-regulation of gastric mucosal blood circulation - down-regulation of stomach mucosal blood circulation - downregulation of gastric mucosal blood circulation - downregulation of stomach mucosal blood circulation - negative regulation of stomach mucosal blood circulation - inhibition of gastric mucosal blood circulation - inhibition of stomach mucosal blood circulation - biological_process - GO:1904345 - negative regulation of gastric mucosal blood circulation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation. - GOC:TermGenie - GO_REF:0000058 - PMID:10807413 - - - - - down regulation of gastric mucosal blood circulation - GOC:TermGenie - - - - - down regulation of stomach mucosal blood circulation - GOC:TermGenie - - - - - down-regulation of gastric mucosal blood circulation - GOC:TermGenie - - - - - down-regulation of stomach mucosal blood circulation - GOC:TermGenie - - - - - downregulation of gastric mucosal blood circulation - GOC:TermGenie - - - - - downregulation of stomach mucosal blood circulation - GOC:TermGenie - - - - - negative regulation of stomach mucosal blood circulation - GOC:TermGenie - - - - - inhibition of gastric mucosal blood circulation - GOC:TermGenie - - - - - inhibition of stomach mucosal blood circulation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation. - sl - 2015-06-11T21:20:50Z - positive regulation of stomach mucosal blood circulation - up regulation of gastric mucosal blood circulation - up regulation of stomach mucosal blood circulation - up-regulation of gastric mucosal blood circulation - up-regulation of stomach mucosal blood circulation - upregulation of gastric mucosal blood circulation - upregulation of stomach mucosal blood circulation - activation of gastric mucosal blood circulation - activation of stomach mucosal blood circulation - biological_process - GO:1904346 - positive regulation of gastric mucosal blood circulation - - - - - Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation. - GOC:TermGenie - GO_REF:0000058 - PMID:10807413 - - - - - positive regulation of stomach mucosal blood circulation - GOC:TermGenie - - - - - up regulation of gastric mucosal blood circulation - GOC:TermGenie - - - - - up regulation of stomach mucosal blood circulation - GOC:TermGenie - - - - - up-regulation of gastric mucosal blood circulation - GOC:TermGenie - - - - - up-regulation of stomach mucosal blood circulation - GOC:TermGenie - - - - - upregulation of gastric mucosal blood circulation - GOC:TermGenie - - - - - upregulation of stomach mucosal blood circulation - GOC:TermGenie - - - - - activation of gastric mucosal blood circulation - GOC:TermGenie - - - - - activation of stomach mucosal blood circulation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction. - sl - 2015-06-11T21:37:34Z - biological_process - GO:1904347 - regulation of small intestine smooth muscle contraction - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction. - GOC:TermGenie - GO_REF:0000058 - PMID:11991626 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction. - sl - 2015-06-11T21:37:40Z - down regulation of small intestine smooth muscle contraction - down-regulation of small intestine smooth muscle contraction - downregulation of small intestine smooth muscle contraction - inhibition of small intestine smooth muscle contraction - biological_process - GO:1904348 - negative regulation of small intestine smooth muscle contraction - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction. - GOC:TermGenie - GO_REF:0000058 - PMID:11991626 - - - - - down regulation of small intestine smooth muscle contraction - GOC:TermGenie - - - - - down-regulation of small intestine smooth muscle contraction - GOC:TermGenie - - - - - downregulation of small intestine smooth muscle contraction - GOC:TermGenie - - - - - inhibition of small intestine smooth muscle contraction - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction. - sl - 2015-06-11T21:37:46Z - up regulation of small intestine smooth muscle contraction - up-regulation of small intestine smooth muscle contraction - upregulation of small intestine smooth muscle contraction - activation of small intestine smooth muscle contraction - biological_process - GO:1904349 - positive regulation of small intestine smooth muscle contraction - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction. - GOC:TermGenie - GO_REF:0000058 - PMID:11991626 - - - - - up regulation of small intestine smooth muscle contraction - GOC:TermGenie - - - - - up-regulation of small intestine smooth muscle contraction - GOC:TermGenie - - - - - upregulation of small intestine smooth muscle contraction - GOC:TermGenie - - - - - activation of small intestine smooth muscle contraction - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole. - rl - 2015-06-12T09:10:36Z - biological_process - regulation of vacuolar protein breakdown - regulation of vacuolar protein catabolic process - regulation of vacuolar protein catabolism - regulation of vacuolar protein degradation - GO:1904350 - regulation of protein catabolic process in the vacuole - - - - - Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:25635054 - - - - - regulation of vacuolar protein breakdown - GOC:TermGenie - - - - - regulation of vacuolar protein catabolic process - GOC:TermGenie - - - - - regulation of vacuolar protein catabolism - GOC:TermGenie - - - - - regulation of vacuolar protein degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole. - rl - 2015-06-12T09:10:42Z - down regulation of protein catabolic process in the vacuole - down-regulation of protein catabolic process in the vacuole - downregulation of protein catabolic process in the vacuole - inhibition of protein catabolic process in the vacuole - biological_process - down regulation of vacuolar protein breakdown - down regulation of vacuolar protein catabolic process - down regulation of vacuolar protein catabolism - down regulation of vacuolar protein degradation - down-regulation of vacuolar protein breakdown - down-regulation of vacuolar protein catabolic process - down-regulation of vacuolar protein catabolism - down-regulation of vacuolar protein degradation - downregulation of vacuolar protein breakdown - downregulation of vacuolar protein catabolic process - downregulation of vacuolar protein catabolism - downregulation of vacuolar protein degradation - inhibition of vacuolar protein breakdown - inhibition of vacuolar protein catabolic process - inhibition of vacuolar protein catabolism - inhibition of vacuolar protein degradation - negative regulation of vacuolar protein breakdown - negative regulation of vacuolar protein catabolic process - negative regulation of vacuolar protein catabolism - negative regulation of vacuolar protein degradation - GO:1904351 - negative regulation of protein catabolic process in the vacuole - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:25635054 - - - - - down regulation of protein catabolic process in the vacuole - GOC:TermGenie - - - - - down-regulation of protein catabolic process in the vacuole - GOC:TermGenie - - - - - downregulation of protein catabolic process in the vacuole - GOC:TermGenie - - - - - inhibition of protein catabolic process in the vacuole - GOC:TermGenie - - - - - down regulation of vacuolar protein breakdown - GOC:TermGenie - - - - - down regulation of vacuolar protein catabolic process - GOC:TermGenie - - - - - down regulation of vacuolar protein catabolism - GOC:TermGenie - - - - - down regulation of vacuolar protein degradation - GOC:TermGenie - - - - - down-regulation of vacuolar protein breakdown - GOC:TermGenie - - - - - down-regulation of vacuolar protein catabolic process - GOC:TermGenie - - - - - down-regulation of vacuolar protein catabolism - GOC:TermGenie - - - - - down-regulation of vacuolar protein degradation - GOC:TermGenie - - - - - downregulation of vacuolar protein breakdown - GOC:TermGenie - - - - - downregulation of vacuolar protein catabolic process - GOC:TermGenie - - - - - downregulation of vacuolar protein catabolism - GOC:TermGenie - - - - - downregulation of vacuolar protein degradation - GOC:TermGenie - - - - - inhibition of vacuolar protein breakdown - GOC:TermGenie - - - - - inhibition of vacuolar protein catabolic process - GOC:TermGenie - - - - - inhibition of vacuolar protein catabolism - GOC:TermGenie - - - - - inhibition of vacuolar protein degradation - GOC:TermGenie - - - - - negative regulation of vacuolar protein breakdown - GOC:TermGenie - - - - - negative regulation of vacuolar protein catabolic process - GOC:TermGenie - - - - - negative regulation of vacuolar protein catabolism - GOC:TermGenie - - - - - negative regulation of vacuolar protein degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole. - rl - 2015-06-12T09:10:49Z - up regulation of protein catabolic process in the vacuole - up-regulation of protein catabolic process in the vacuole - upregulation of protein catabolic process in the vacuole - activation of protein catabolic process in the vacuole - biological_process - activation of vacuolar protein breakdown - activation of vacuolar protein catabolic process - activation of vacuolar protein catabolism - activation of vacuolar protein degradation - positive regulation of vacuolar protein breakdown - positive regulation of vacuolar protein catabolic process - positive regulation of vacuolar protein catabolism - positive regulation of vacuolar protein degradation - up regulation of vacuolar protein breakdown - up regulation of vacuolar protein catabolic process - up regulation of vacuolar protein catabolism - up regulation of vacuolar protein degradation - up-regulation of vacuolar protein breakdown - up-regulation of vacuolar protein catabolic process - up-regulation of vacuolar protein catabolism - up-regulation of vacuolar protein degradation - upregulation of vacuolar protein breakdown - upregulation of vacuolar protein catabolic process - upregulation of vacuolar protein catabolism - upregulation of vacuolar protein degradation - GO:1904352 - positive regulation of protein catabolic process in the vacuole - - - - - Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:25635054 - - - - - up regulation of protein catabolic process in the vacuole - GOC:TermGenie - - - - - up-regulation of protein catabolic process in the vacuole - GOC:TermGenie - - - - - upregulation of protein catabolic process in the vacuole - GOC:TermGenie - - - - - activation of protein catabolic process in the vacuole - GOC:TermGenie - - - - - activation of vacuolar protein breakdown - GOC:TermGenie - - - - - activation of vacuolar protein catabolic process - GOC:TermGenie - - - - - activation of vacuolar protein catabolism - GOC:TermGenie - - - - - activation of vacuolar protein degradation - GOC:TermGenie - - - - - positive regulation of vacuolar protein breakdown - GOC:TermGenie - - - - - positive regulation of vacuolar protein catabolic process - GOC:TermGenie - - - - - positive regulation of vacuolar protein catabolism - GOC:TermGenie - - - - - positive regulation of vacuolar protein degradation - GOC:TermGenie - - - - - up regulation of vacuolar protein breakdown - GOC:TermGenie - - - - - up regulation of vacuolar protein catabolic process - GOC:TermGenie - - - - - up regulation of vacuolar protein catabolism - GOC:TermGenie - - - - - up regulation of vacuolar protein degradation - GOC:TermGenie - - - - - up-regulation of vacuolar protein breakdown - GOC:TermGenie - - - - - up-regulation of vacuolar protein catabolic process - GOC:TermGenie - - - - - up-regulation of vacuolar protein catabolism - GOC:TermGenie - - - - - up-regulation of vacuolar protein degradation - GOC:TermGenie - - - - - upregulation of vacuolar protein breakdown - GOC:TermGenie - - - - - upregulation of vacuolar protein catabolic process - GOC:TermGenie - - - - - upregulation of vacuolar protein catabolism - GOC:TermGenie - - - - - upregulation of vacuolar protein degradation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of protein localization to cell periphery. - sl - 2015-06-22T22:09:25Z - biological_process - GO:1904375 - regulation of protein localization to cell periphery - - - - - Any process that modulates the frequency, rate or extent of protein localization to cell periphery. - GOC:TermGenie - GO_REF:0000058 - PMID:18216290 - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery. - sl - 2015-06-22T22:09:32Z - down regulation of protein localization to cell periphery - down-regulation of protein localization to cell periphery - downregulation of protein localization to cell periphery - inhibition of protein localization to cell periphery - biological_process - GO:1904376 - negative regulation of protein localization to cell periphery - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery. - GOC:TermGenie - GO_REF:0000058 - PMID:18216290 - - - - - down regulation of protein localization to cell periphery - GOC:TermGenie - - - - - down-regulation of protein localization to cell periphery - GOC:TermGenie - - - - - downregulation of protein localization to cell periphery - GOC:TermGenie - - - - - inhibition of protein localization to cell periphery - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. - sl - 2015-06-22T22:09:37Z - up regulation of protein localization to cell periphery - up-regulation of protein localization to cell periphery - upregulation of protein localization to cell periphery - activation of protein localization to cell periphery - biological_process - GO:1904377 - positive regulation of protein localization to cell periphery - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. - GOC:TermGenie - GO_REF:0000058 - PMID:18216290 - - - - - up regulation of protein localization to cell periphery - GOC:TermGenie - - - - - up-regulation of protein localization to cell periphery - GOC:TermGenie - - - - - upregulation of protein localization to cell periphery - GOC:TermGenie - - - - - activation of protein localization to cell periphery - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of neuromuscular junction development. - sl - 2015-06-23T19:23:42Z - regulation of neuromuscular junction organization - biological_process - regulation of NMJ stability - regulation of neuromuscular junction stability - GO:1904396 - regulation of neuromuscular junction development - - - - - Any process that modulates the frequency, rate or extent of neuromuscular junction development. - GOC:TermGenie - GO_REF:0000058 - PMID:7722643 - - - - - regulation of neuromuscular junction organization - GOC:TermGenie - - - - - regulation of NMJ stability - GOC:TermGenie - - - - - regulation of neuromuscular junction stability - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development. - sl - 2015-06-23T19:23:48Z - down regulation of neuromuscular junction development - down regulation of neuromuscular junction organization - down-regulation of neuromuscular junction development - down-regulation of neuromuscular junction organization - downregulation of neuromuscular junction development - downregulation of neuromuscular junction organization - negative regulation of neuromuscular junction organization - inhibition of neuromuscular junction development - inhibition of neuromuscular junction organization - biological_process - down regulation of NMJ stability - down regulation of neuromuscular junction stability - down-regulation of NMJ stability - down-regulation of neuromuscular junction stability - downregulation of NMJ stability - downregulation of neuromuscular junction stability - inhibition of NMJ stability - inhibition of neuromuscular junction stability - negative regulation of NMJ stability - negative regulation of neuromuscular junction stability - GO:1904397 - negative regulation of neuromuscular junction development - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development. - GOC:TermGenie - GO_REF:0000058 - PMID:7722643 - - - - - down regulation of neuromuscular junction development - GOC:TermGenie - - - - - down regulation of neuromuscular junction organization - GOC:TermGenie - - - - - down-regulation of neuromuscular junction development - GOC:TermGenie - - - - - down-regulation of neuromuscular junction organization - GOC:TermGenie - - - - - downregulation of neuromuscular junction development - GOC:TermGenie - - - - - downregulation of neuromuscular junction organization - GOC:TermGenie - - - - - negative regulation of neuromuscular junction organization - GOC:TermGenie - - - - - inhibition of neuromuscular junction development - GOC:TermGenie - - - - - inhibition of neuromuscular junction organization - GOC:TermGenie - - - - - down regulation of NMJ stability - GOC:TermGenie - - - - - down regulation of neuromuscular junction stability - GOC:TermGenie - - - - - down-regulation of NMJ stability - GOC:TermGenie - - - - - down-regulation of neuromuscular junction stability - GOC:TermGenie - - - - - downregulation of NMJ stability - GOC:TermGenie - - - - - downregulation of neuromuscular junction stability - GOC:TermGenie - - - - - inhibition of NMJ stability - GOC:TermGenie - - - - - inhibition of neuromuscular junction stability - GOC:TermGenie - - - - - negative regulation of NMJ stability - GOC:TermGenie - - - - - negative regulation of neuromuscular junction stability - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of neuromuscular junction development. - sl - 2015-06-23T19:23:54Z - positive regulation of neuromuscular junction organization - up regulation of neuromuscular junction development - up regulation of neuromuscular junction organization - up-regulation of neuromuscular junction development - up-regulation of neuromuscular junction organization - upregulation of neuromuscular junction development - upregulation of neuromuscular junction organization - activation of neuromuscular junction development - activation of neuromuscular junction organization - biological_process - activation of NMJ stability - activation of neuromuscular junction stability - positive regulation of NMJ stability - positive regulation of neuromuscular junction stability - up regulation of NMJ stability - up regulation of neuromuscular junction stability - up-regulation of NMJ stability - up-regulation of neuromuscular junction stability - upregulation of NMJ stability - upregulation of neuromuscular junction stability - GO:1904398 - positive regulation of neuromuscular junction development - - - - - Any process that activates or increases the frequency, rate or extent of neuromuscular junction development. - GOC:TermGenie - GO_REF:0000058 - PMID:7722643 - - - - - positive regulation of neuromuscular junction organization - GOC:TermGenie - - - - - up regulation of neuromuscular junction development - GOC:TermGenie - - - - - up regulation of neuromuscular junction organization - GOC:TermGenie - - - - - up-regulation of neuromuscular junction development - GOC:TermGenie - - - - - up-regulation of neuromuscular junction organization - GOC:TermGenie - - - - - upregulation of neuromuscular junction development - GOC:TermGenie - - - - - upregulation of neuromuscular junction organization - GOC:TermGenie - - - - - activation of neuromuscular junction development - GOC:TermGenie - - - - - activation of neuromuscular junction organization - GOC:TermGenie - - - - - activation of NMJ stability - GOC:TermGenie - - - - - activation of neuromuscular junction stability - GOC:TermGenie - - - - - positive regulation of NMJ stability - GOC:TermGenie - - - - - positive regulation of neuromuscular junction stability - GOC:TermGenie - - - - - up regulation of NMJ stability - GOC:TermGenie - - - - - up regulation of neuromuscular junction stability - GOC:TermGenie - - - - - up-regulation of NMJ stability - GOC:TermGenie - - - - - up-regulation of neuromuscular junction stability - GOC:TermGenie - - - - - upregulation of NMJ stability - GOC:TermGenie - - - - - upregulation of neuromuscular junction stability - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of secretory granule organization. - sl - 2015-06-25T19:40:42Z - regulation of secretory granule organisation - biological_process - regulation of secretory granule organization and biogenesis - GO:1904409 - regulation of secretory granule organization - - - - - Any process that modulates the frequency, rate or extent of secretory granule organization. - GOC:TermGenie - GO_REF:0000058 - PMID:15039777 - - - - - regulation of secretory granule organisation - GOC:TermGenie - - - - - regulation of secretory granule organization and biogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization. - sl - 2015-06-25T19:40:49Z - down regulation of secretory granule organisation - down regulation of secretory granule organization - down-regulation of secretory granule organisation - down-regulation of secretory granule organization - downregulation of secretory granule organisation - downregulation of secretory granule organization - negative regulation of secretory granule organisation - inhibition of secretory granule organisation - inhibition of secretory granule organization - biological_process - down regulation of secretory granule organization and biogenesis - down-regulation of secretory granule organization and biogenesis - downregulation of secretory granule organization and biogenesis - inhibition of secretory granule organization and biogenesis - negative regulation of secretory granule organization and biogenesis - GO:1904410 - negative regulation of secretory granule organization - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization. - GOC:TermGenie - GO_REF:0000058 - PMID:15039777 - - - - - down regulation of secretory granule organisation - GOC:TermGenie - - - - - down regulation of secretory granule organization - GOC:TermGenie - - - - - down-regulation of secretory granule organisation - GOC:TermGenie - - - - - down-regulation of secretory granule organization - GOC:TermGenie - - - - - downregulation of secretory granule organisation - GOC:TermGenie - - - - - downregulation of secretory granule organization - GOC:TermGenie - - - - - negative regulation of secretory granule organisation - GOC:TermGenie - - - - - inhibition of secretory granule organisation - GOC:TermGenie - - - - - inhibition of secretory granule organization - GOC:TermGenie - - - - - down regulation of secretory granule organization and biogenesis - GOC:TermGenie - - - - - down-regulation of secretory granule organization and biogenesis - GOC:TermGenie - - - - - downregulation of secretory granule organization and biogenesis - GOC:TermGenie - - - - - inhibition of secretory granule organization and biogenesis - GOC:TermGenie - - - - - negative regulation of secretory granule organization and biogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of secretory granule organization. - sl - 2015-06-25T19:40:55Z - positive regulation of secretory granule organisation - up regulation of secretory granule organisation - up regulation of secretory granule organization - up-regulation of secretory granule organisation - up-regulation of secretory granule organization - upregulation of secretory granule organisation - upregulation of secretory granule organization - activation of secretory granule organisation - activation of secretory granule organization - biological_process - activation of secretory granule organization and biogenesis - positive regulation of secretory granule organization and biogenesis - up regulation of secretory granule organization and biogenesis - up-regulation of secretory granule organization and biogenesis - upregulation of secretory granule organization and biogenesis - GO:1904411 - positive regulation of secretory granule organization - - - - - Any process that activates or increases the frequency, rate or extent of secretory granule organization. - GOC:TermGenie - GO_REF:0000058 - PMID:15039777 - - - - - positive regulation of secretory granule organisation - GOC:TermGenie - - - - - up regulation of secretory granule organisation - GOC:TermGenie - - - - - up regulation of secretory granule organization - GOC:TermGenie - - - - - up-regulation of secretory granule organisation - GOC:TermGenie - - - - - up-regulation of secretory granule organization - GOC:TermGenie - - - - - upregulation of secretory granule organisation - GOC:TermGenie - - - - - upregulation of secretory granule organization - GOC:TermGenie - - - - - activation of secretory granule organisation - GOC:TermGenie - - - - - activation of secretory granule organization - GOC:TermGenie - - - - - activation of secretory granule organization and biogenesis - GOC:TermGenie - - - - - positive regulation of secretory granule organization and biogenesis - GOC:TermGenie - - - - - up regulation of secretory granule organization and biogenesis - GOC:TermGenie - - - - - up-regulation of secretory granule organization and biogenesis - GOC:TermGenie - - - - - upregulation of secretory granule organization and biogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of cardiac ventricle development. - sl - 2015-06-25T19:52:15Z - biological_process - GO:1904412 - regulation of cardiac ventricle development - - - - - Any process that modulates the frequency, rate or extent of cardiac ventricle development. - GOC:TermGenie - GO_REF:0000058 - PMID:19590510 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development. - sl - 2015-06-25T19:52:21Z - down regulation of cardiac ventricle development - down-regulation of cardiac ventricle development - downregulation of cardiac ventricle development - inhibition of cardiac ventricle development - biological_process - GO:1904413 - negative regulation of cardiac ventricle development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development. - GOC:TermGenie - GO_REF:0000058 - PMID:19590510 - - - - - down regulation of cardiac ventricle development - GOC:TermGenie - - - - - down-regulation of cardiac ventricle development - GOC:TermGenie - - - - - downregulation of cardiac ventricle development - GOC:TermGenie - - - - - inhibition of cardiac ventricle development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of cardiac ventricle development. - sl - 2015-06-25T19:52:27Z - up regulation of cardiac ventricle development - up-regulation of cardiac ventricle development - upregulation of cardiac ventricle development - activation of cardiac ventricle development - biological_process - GO:1904414 - positive regulation of cardiac ventricle development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of cardiac ventricle development. - GOC:TermGenie - GO_REF:0000058 - PMID:19590510 - - - - - up regulation of cardiac ventricle development - GOC:TermGenie - - - - - up-regulation of cardiac ventricle development - GOC:TermGenie - - - - - upregulation of cardiac ventricle development - GOC:TermGenie - - - - - activation of cardiac ventricle development - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential. - sl - 2015-07-09T18:02:40Z - down regulation of neuronal action potential - down-regulation of neuronal action potential - downregulation of neuronal action potential - inhibition of neuronal action potential - biological_process - down regulation of generation of action potential - down-regulation of generation of action potential - downregulation of generation of action potential - inhibition of generation of action potential - negative regulation of generation of action potential - GO:1904456 - negative regulation of neuronal action potential - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential. - GOC:TermGenie - GO_REF:0000058 - PMID:25126967 - - - - - down regulation of neuronal action potential - GOC:TermGenie - - - - - down-regulation of neuronal action potential - GOC:TermGenie - - - - - downregulation of neuronal action potential - GOC:TermGenie - - - - - inhibition of neuronal action potential - GOC:TermGenie - - - - - down regulation of generation of action potential - GOC:TermGenie - - - - - down-regulation of generation of action potential - GOC:TermGenie - - - - - downregulation of generation of action potential - GOC:TermGenie - - - - - inhibition of generation of action potential - GOC:TermGenie - - - - - negative regulation of generation of action potential - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of neuronal action potential. - sl - 2015-07-09T18:02:46Z - up regulation of neuronal action potential - up-regulation of neuronal action potential - upregulation of neuronal action potential - activation of neuronal action potential - biological_process - activation of generation of action potential - positive regulation of generation of action potential - up regulation of generation of action potential - up-regulation of generation of action potential - upregulation of generation of action potential - GO:1904457 - positive regulation of neuronal action potential - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of neuronal action potential. - GOC:TermGenie - GO_REF:0000058 - PMID:25126967 - - - - - up regulation of neuronal action potential - GOC:TermGenie - - - - - up-regulation of neuronal action potential - GOC:TermGenie - - - - - upregulation of neuronal action potential - GOC:TermGenie - - - - - activation of neuronal action potential - GOC:TermGenie - - - - - activation of generation of action potential - GOC:TermGenie - - - - - positive regulation of generation of action potential - GOC:TermGenie - - - - - up regulation of generation of action potential - GOC:TermGenie - - - - - up-regulation of generation of action potential - GOC:TermGenie - - - - - upregulation of generation of action potential - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure. - mr - 2015-07-15T22:14:39Z - biological_process - GO:1904484 - cloacal gland development - - - - - The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure. - GOC:TermGenie - GOC:mr - GO_REF:0000094 - PMID:18805421 - - - - - - - - - - - - - - - - - - - - - - - - - - A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone. - kmv - 2015-07-17T20:43:21Z - protein localisation in ciliary transition zone - protein localisation to ciliary transition zone - protein localization in ciliary transition zone - biological_process - GO:1904491 - protein localization to ciliary transition zone - - - - - A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone. - GOC:TermGenie - GOC:kmv - GO_REF:0000087 - PMID:21422230 - - - - - protein localisation in ciliary transition zone - GOC:TermGenie - - - - - protein localisation to ciliary transition zone - GOC:TermGenie - - - - - protein localization in ciliary transition zone - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. - sl - 2015-08-20T16:46:24Z - response to glycoproteins - biological_process - GO:1904587 - response to glycoprotein - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. - GOC:TermGenie - GO_REF:0000071 - PMID:14597422 - - - - - - - - - - - - - - - - - - - - - - - - - - Any apoptotic process in a fat cell. - sl - 2015-08-27T18:13:06Z - adipocyte apoptotic process - adipose cell apoptotic process - adipocyte apoptosis - adipose cell apoptosis - fat cell apoptosis - biological_process - GO:1904606 - fat cell apoptotic process - - - - - Any apoptotic process in a fat cell. - GOC:TermGenie - GO_REF:0000085 - PMID:17024416 - - - - - adipocyte apoptotic process - GOC:TermGenie - - - - - adipose cell apoptotic process - GOC:TermGenie - - - - - adipocyte apoptosis - GOC:TermGenie - - - - - adipose cell apoptosis - GOC:TermGenie - - - - - fat cell apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of fat cell apoptotic process. - sl - 2015-08-31T20:59:28Z - regulation of adipocyte apoptotic process - regulation of adipose cell apoptotic process - regulation of adipocyte apoptosis - regulation of adipose cell apoptosis - regulation of fat cell apoptosis - biological_process - GO:1904649 - regulation of fat cell apoptotic process - - - - - Any process that modulates the frequency, rate or extent of fat cell apoptotic process. - GOC:TermGenie - GO_REF:0000058 - PMID:17024416 - - - - - regulation of adipocyte apoptotic process - GOC:TermGenie - - - - - regulation of adipose cell apoptotic process - GOC:TermGenie - - - - - regulation of adipocyte apoptosis - GOC:TermGenie - - - - - regulation of adipose cell apoptosis - GOC:TermGenie - - - - - regulation of fat cell apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process. - sl - 2015-08-31T20:59:34Z - down regulation of adipocyte apoptotic process - down regulation of adipose cell apoptotic process - down regulation of fat cell apoptotic process - down-regulation of adipocyte apoptotic process - down-regulation of adipose cell apoptotic process - down-regulation of fat cell apoptotic process - downregulation of adipocyte apoptotic process - downregulation of adipose cell apoptotic process - downregulation of fat cell apoptotic process - negative regulation of adipocyte apoptotic process - negative regulation of adipose cell apoptotic process - down regulation of adipocyte apoptosis - down regulation of adipose cell apoptosis - down regulation of fat cell apoptosis - down-regulation of adipocyte apoptosis - down-regulation of adipose cell apoptosis - down-regulation of fat cell apoptosis - downregulation of adipocyte apoptosis - downregulation of adipose cell apoptosis - downregulation of fat cell apoptosis - inhibition of adipocyte apoptosis - inhibition of adipocyte apoptotic process - inhibition of adipose cell apoptosis - inhibition of adipose cell apoptotic process - inhibition of fat cell apoptosis - inhibition of fat cell apoptotic process - negative regulation of adipocyte apoptosis - negative regulation of adipose cell apoptosis - negative regulation of fat cell apoptosis - biological_process - GO:1904650 - negative regulation of fat cell apoptotic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process. - GOC:TermGenie - GO_REF:0000058 - PMID:17024416 - - - - - down regulation of adipocyte apoptotic process - GOC:TermGenie - - - - - down regulation of adipose cell apoptotic process - GOC:TermGenie - - - - - down regulation of fat cell apoptotic process - GOC:TermGenie - - - - - down-regulation of adipocyte apoptotic process - GOC:TermGenie - - - - - down-regulation of adipose cell apoptotic process - GOC:TermGenie - - - - - down-regulation of fat cell apoptotic process - GOC:TermGenie - - - - - downregulation of adipocyte apoptotic process - GOC:TermGenie - - - - - downregulation of adipose cell apoptotic process - GOC:TermGenie - - - - - downregulation of fat cell apoptotic process - GOC:TermGenie - - - - - negative regulation of adipocyte apoptotic process - GOC:TermGenie - - - - - negative regulation of adipose cell apoptotic process - GOC:TermGenie - - - - - down regulation of adipocyte apoptosis - GOC:TermGenie - - - - - down regulation of adipose cell apoptosis - GOC:TermGenie - - - - - down regulation of fat cell apoptosis - GOC:TermGenie - - - - - down-regulation of adipocyte apoptosis - GOC:TermGenie - - - - - down-regulation of adipose cell apoptosis - GOC:TermGenie - - - - - down-regulation of fat cell apoptosis - GOC:TermGenie - - - - - downregulation of adipocyte apoptosis - GOC:TermGenie - - - - - downregulation of adipose cell apoptosis - GOC:TermGenie - - - - - downregulation of fat cell apoptosis - GOC:TermGenie - - - - - inhibition of adipocyte apoptosis - GOC:TermGenie - - - - - inhibition of adipocyte apoptotic process - GOC:TermGenie - - - - - inhibition of adipose cell apoptosis - GOC:TermGenie - - - - - inhibition of adipose cell apoptotic process - GOC:TermGenie - - - - - inhibition of fat cell apoptosis - GOC:TermGenie - - - - - inhibition of fat cell apoptotic process - GOC:TermGenie - - - - - negative regulation of adipocyte apoptosis - GOC:TermGenie - - - - - negative regulation of adipose cell apoptosis - GOC:TermGenie - - - - - negative regulation of fat cell apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process. - sl - 2015-08-31T20:59:40Z - positive regulation of adipocyte apoptotic process - positive regulation of adipose cell apoptotic process - up regulation of adipocyte apoptotic process - up regulation of adipose cell apoptotic process - up regulation of fat cell apoptotic process - up-regulation of adipocyte apoptotic process - up-regulation of adipose cell apoptotic process - up-regulation of fat cell apoptotic process - upregulation of adipocyte apoptotic process - upregulation of adipose cell apoptotic process - upregulation of fat cell apoptotic process - activation of adipocyte apoptosis - activation of adipocyte apoptotic process - activation of adipose cell apoptosis - activation of adipose cell apoptotic process - activation of fat cell apoptosis - activation of fat cell apoptotic process - positive regulation of adipocyte apoptosis - positive regulation of adipose cell apoptosis - positive regulation of fat cell apoptosis - up regulation of adipocyte apoptosis - up regulation of adipose cell apoptosis - up regulation of fat cell apoptosis - up-regulation of adipocyte apoptosis - up-regulation of adipose cell apoptosis - up-regulation of fat cell apoptosis - upregulation of adipocyte apoptosis - upregulation of adipose cell apoptosis - upregulation of fat cell apoptosis - biological_process - GO:1904651 - positive regulation of fat cell apoptotic process - - - - - Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process. - GOC:TermGenie - GO_REF:0000058 - PMID:17024416 - - - - - positive regulation of adipocyte apoptotic process - GOC:TermGenie - - - - - positive regulation of adipose cell apoptotic process - GOC:TermGenie - - - - - up regulation of adipocyte apoptotic process - GOC:TermGenie - - - - - up regulation of adipose cell apoptotic process - GOC:TermGenie - - - - - up regulation of fat cell apoptotic process - GOC:TermGenie - - - - - up-regulation of adipocyte apoptotic process - GOC:TermGenie - - - - - up-regulation of adipose cell apoptotic process - GOC:TermGenie - - - - - up-regulation of fat cell apoptotic process - GOC:TermGenie - - - - - upregulation of adipocyte apoptotic process - GOC:TermGenie - - - - - upregulation of adipose cell apoptotic process - GOC:TermGenie - - - - - upregulation of fat cell apoptotic process - GOC:TermGenie - - - - - activation of adipocyte apoptosis - GOC:TermGenie - - - - - activation of adipocyte apoptotic process - GOC:TermGenie - - - - - activation of adipose cell apoptosis - GOC:TermGenie - - - - - activation of adipose cell apoptotic process - GOC:TermGenie - - - - - activation of fat cell apoptosis - GOC:TermGenie - - - - - activation of fat cell apoptotic process - GOC:TermGenie - - - - - positive regulation of adipocyte apoptosis - GOC:TermGenie - - - - - positive regulation of adipose cell apoptosis - GOC:TermGenie - - - - - positive regulation of fat cell apoptosis - GOC:TermGenie - - - - - up regulation of adipocyte apoptosis - GOC:TermGenie - - - - - up regulation of adipose cell apoptosis - GOC:TermGenie - - - - - up regulation of fat cell apoptosis - GOC:TermGenie - - - - - up-regulation of adipocyte apoptosis - GOC:TermGenie - - - - - up-regulation of adipose cell apoptosis - GOC:TermGenie - - - - - up-regulation of fat cell apoptosis - GOC:TermGenie - - - - - upregulation of adipocyte apoptosis - GOC:TermGenie - - - - - upregulation of adipose cell apoptosis - GOC:TermGenie - - - - - upregulation of fat cell apoptosis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process in which glucose is transported across a membrane. - vw - 2015-09-04T17:20:16Z - GO:0015758 - biological_process - glucose transport - GO:1904659 - glucose transmembrane transport - - - - - The process in which glucose is transported across a membrane. - GOC:TermGenie - GO_REF:0000069 - PMID:9090050 - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of somatic stem cell division. - rph - 2015-09-14T08:47:22Z - regulation of somatic stem cell renewal - biological_process - GO:1904675 - regulation of somatic stem cell division - - - - - Any process that modulates the frequency, rate or extent of somatic stem cell division. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:19409607 - - - - - regulation of somatic stem cell renewal - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division. - rph - 2015-09-14T08:47:28Z - down regulation of somatic stem cell division - down regulation of somatic stem cell renewal - down-regulation of somatic stem cell division - down-regulation of somatic stem cell renewal - downregulation of somatic stem cell division - downregulation of somatic stem cell renewal - negative regulation of somatic stem cell renewal - inhibition of somatic stem cell division - inhibition of somatic stem cell renewal - biological_process - GO:1904676 - negative regulation of somatic stem cell division - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:19409607 - - - - - down regulation of somatic stem cell division - GOC:TermGenie - - - - - down regulation of somatic stem cell renewal - GOC:TermGenie - - - - - down-regulation of somatic stem cell division - GOC:TermGenie - - - - - down-regulation of somatic stem cell renewal - GOC:TermGenie - - - - - downregulation of somatic stem cell division - GOC:TermGenie - - - - - downregulation of somatic stem cell renewal - GOC:TermGenie - - - - - negative regulation of somatic stem cell renewal - GOC:TermGenie - - - - - inhibition of somatic stem cell division - GOC:TermGenie - - - - - inhibition of somatic stem cell renewal - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of somatic stem cell division. - rph - 2015-09-14T08:47:34Z - positive regulation of somatic stem cell renewal - up regulation of somatic stem cell division - up regulation of somatic stem cell renewal - up-regulation of somatic stem cell division - up-regulation of somatic stem cell renewal - upregulation of somatic stem cell division - upregulation of somatic stem cell renewal - activation of somatic stem cell division - activation of somatic stem cell renewal - biological_process - GO:1904677 - positive regulation of somatic stem cell division - - - - - Any process that activates or increases the frequency, rate or extent of somatic stem cell division. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:19409607 - - - - - positive regulation of somatic stem cell renewal - GOC:TermGenie - - - - - up regulation of somatic stem cell division - GOC:TermGenie - - - - - up regulation of somatic stem cell renewal - GOC:TermGenie - - - - - up-regulation of somatic stem cell division - GOC:TermGenie - - - - - up-regulation of somatic stem cell renewal - GOC:TermGenie - - - - - upregulation of somatic stem cell division - GOC:TermGenie - - - - - upregulation of somatic stem cell renewal - GOC:TermGenie - - - - - activation of somatic stem cell division - GOC:TermGenie - - - - - activation of somatic stem cell renewal - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Enables the transfer of a peptide from one side of a membrane to the other. - tb - 2015-09-22T18:50:41Z - GO:0015197 - GO:0015637 - Reactome:R-HSA-1500817 - molecular_function - peptide transporter activity - peptide uptake permease activity - GO:1904680 - peptide transmembrane transporter activity - - - - - Enables the transfer of a peptide from one side of a membrane to the other. - GOC:TermGenie - GOC:vw - GO_REF:0000070 - - - - - Reactome:R-HSA-1500817 - Glutathione is taken up by the bacterium - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation. - sl - 2015-09-25T15:23:38Z - down regulation of pancreatic B cell proliferation - down regulation of pancreatic beta cell proliferation - down regulation of type B pancreatic cell proliferation - down-regulation of pancreatic B cell proliferation - down-regulation of pancreatic beta cell proliferation - down-regulation of type B pancreatic cell proliferation - downregulation of pancreatic B cell proliferation - downregulation of pancreatic beta cell proliferation - downregulation of type B pancreatic cell proliferation - negative regulation of pancreatic B cell proliferation - negative regulation of pancreatic beta cell proliferation - inhibition of pancreatic B cell proliferation - inhibition of pancreatic beta cell proliferation - inhibition of type B pancreatic cell proliferation - biological_process - GO:1904691 - negative regulation of type B pancreatic cell proliferation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:24055447 - - - - - down regulation of pancreatic B cell proliferation - GOC:TermGenie - - - - - down regulation of pancreatic beta cell proliferation - GOC:TermGenie - - - - - down regulation of type B pancreatic cell proliferation - GOC:TermGenie - - - - - down-regulation of pancreatic B cell proliferation - GOC:TermGenie - - - - - down-regulation of pancreatic beta cell proliferation - GOC:TermGenie - - - - - down-regulation of type B pancreatic cell proliferation - GOC:TermGenie - - - - - downregulation of pancreatic B cell proliferation - GOC:TermGenie - - - - - downregulation of pancreatic beta cell proliferation - GOC:TermGenie - - - - - downregulation of type B pancreatic cell proliferation - GOC:TermGenie - - - - - negative regulation of pancreatic B cell proliferation - GOC:TermGenie - - - - - negative regulation of pancreatic beta cell proliferation - GOC:TermGenie - - - - - inhibition of pancreatic B cell proliferation - GOC:TermGenie - - - - - inhibition of pancreatic beta cell proliferation - GOC:TermGenie - - - - - inhibition of type B pancreatic cell proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation. - sl - 2015-09-25T15:23:44Z - positive regulation of pancreatic B cell proliferation - positive regulation of pancreatic beta cell proliferation - up regulation of pancreatic B cell proliferation - up regulation of pancreatic beta cell proliferation - up regulation of type B pancreatic cell proliferation - up-regulation of pancreatic B cell proliferation - up-regulation of pancreatic beta cell proliferation - up-regulation of type B pancreatic cell proliferation - upregulation of pancreatic B cell proliferation - upregulation of pancreatic beta cell proliferation - upregulation of type B pancreatic cell proliferation - activation of pancreatic B cell proliferation - activation of pancreatic beta cell proliferation - activation of type B pancreatic cell proliferation - biological_process - GO:1904692 - positive regulation of type B pancreatic cell proliferation - - - - - Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:24055447 - - - - - positive regulation of pancreatic B cell proliferation - GOC:TermGenie - - - - - positive regulation of pancreatic beta cell proliferation - GOC:TermGenie - - - - - up regulation of pancreatic B cell proliferation - GOC:TermGenie - - - - - up regulation of pancreatic beta cell proliferation - GOC:TermGenie - - - - - up regulation of type B pancreatic cell proliferation - GOC:TermGenie - - - - - up-regulation of pancreatic B cell proliferation - GOC:TermGenie - - - - - up-regulation of pancreatic beta cell proliferation - GOC:TermGenie - - - - - up-regulation of type B pancreatic cell proliferation - GOC:TermGenie - - - - - upregulation of pancreatic B cell proliferation - GOC:TermGenie - - - - - upregulation of pancreatic beta cell proliferation - GOC:TermGenie - - - - - upregulation of type B pancreatic cell proliferation - GOC:TermGenie - - - - - activation of pancreatic B cell proliferation - GOC:TermGenie - - - - - activation of pancreatic beta cell proliferation - GOC:TermGenie - - - - - activation of type B pancreatic cell proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The developmental process by which a midbrain is generated and organized. - bf - 2015-09-29T09:15:28Z - MB morphogenesis - biological_process - mesencephalon morphogenesis - GO:1904693 - midbrain morphogenesis - - - - - The developmental process by which a midbrain is generated and organized. - GOC:PARL - GOC:TermGenie - GOC:bf - GO_REF:0000083 - PMID:21347250 - - - - - MB morphogenesis - GOC:TermGenie - - - - - mesencephalon morphogenesis - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of acinar cell proliferation. - sl - 2015-09-30T15:19:50Z - regulation of acinic cell proliferation - regulation of acinous cell proliferation - biological_process - GO:1904697 - regulation of acinar cell proliferation - - - - - Any process that modulates the frequency, rate or extent of acinar cell proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:9788538 - - - - - regulation of acinic cell proliferation - GOC:TermGenie - - - - - regulation of acinous cell proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation. - sl - 2015-09-30T15:19:57Z - down regulation of acinar cell proliferation - down regulation of acinic cell proliferation - down regulation of acinous cell proliferation - down-regulation of acinar cell proliferation - down-regulation of acinic cell proliferation - down-regulation of acinous cell proliferation - downregulation of acinar cell proliferation - downregulation of acinic cell proliferation - downregulation of acinous cell proliferation - negative regulation of acinic cell proliferation - negative regulation of acinous cell proliferation - inhibition of acinar cell proliferation - inhibition of acinic cell proliferation - inhibition of acinous cell proliferation - biological_process - GO:1904698 - negative regulation of acinar cell proliferation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:9788538 - - - - - down regulation of acinar cell proliferation - GOC:TermGenie - - - - - down regulation of acinic cell proliferation - GOC:TermGenie - - - - - down regulation of acinous cell proliferation - GOC:TermGenie - - - - - down-regulation of acinar cell proliferation - GOC:TermGenie - - - - - down-regulation of acinic cell proliferation - GOC:TermGenie - - - - - down-regulation of acinous cell proliferation - GOC:TermGenie - - - - - downregulation of acinar cell proliferation - GOC:TermGenie - - - - - downregulation of acinic cell proliferation - GOC:TermGenie - - - - - downregulation of acinous cell proliferation - GOC:TermGenie - - - - - negative regulation of acinic cell proliferation - GOC:TermGenie - - - - - negative regulation of acinous cell proliferation - GOC:TermGenie - - - - - inhibition of acinar cell proliferation - GOC:TermGenie - - - - - inhibition of acinic cell proliferation - GOC:TermGenie - - - - - inhibition of acinous cell proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of acinar cell proliferation. - sl - 2015-09-30T15:20:03Z - positive regulation of acinic cell proliferation - positive regulation of acinous cell proliferation - up regulation of acinar cell proliferation - up regulation of acinic cell proliferation - up regulation of acinous cell proliferation - up-regulation of acinar cell proliferation - up-regulation of acinic cell proliferation - up-regulation of acinous cell proliferation - upregulation of acinar cell proliferation - upregulation of acinic cell proliferation - upregulation of acinous cell proliferation - activation of acinar cell proliferation - activation of acinic cell proliferation - activation of acinous cell proliferation - biological_process - GO:1904699 - positive regulation of acinar cell proliferation - - - - - Any process that activates or increases the frequency, rate or extent of acinar cell proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:9788538 - - - - - positive regulation of acinic cell proliferation - GOC:TermGenie - - - - - positive regulation of acinous cell proliferation - GOC:TermGenie - - - - - up regulation of acinar cell proliferation - GOC:TermGenie - - - - - up regulation of acinic cell proliferation - GOC:TermGenie - - - - - up regulation of acinous cell proliferation - GOC:TermGenie - - - - - up-regulation of acinar cell proliferation - GOC:TermGenie - - - - - up-regulation of acinic cell proliferation - GOC:TermGenie - - - - - up-regulation of acinous cell proliferation - GOC:TermGenie - - - - - upregulation of acinar cell proliferation - GOC:TermGenie - - - - - upregulation of acinic cell proliferation - GOC:TermGenie - - - - - upregulation of acinous cell proliferation - GOC:TermGenie - - - - - activation of acinar cell proliferation - GOC:TermGenie - - - - - activation of acinic cell proliferation - GOC:TermGenie - - - - - activation of acinous cell proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation. - sl - 2015-10-01T16:05:20Z - regulation of VSMC proliferation - regulation of vascular smooth muscle cell proliferation - biological_process - GO:1904705 - regulation of vascular associated smooth muscle cell proliferation - - - - - Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:23246467 - - - - - regulation of VSMC proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation. - sl - 2015-10-01T16:05:26Z - down regulation of VSMC proliferation - down regulation of vascular smooth muscle cell proliferation - down-regulation of VSMC proliferation - down-regulation of vascular smooth muscle cell proliferation - downregulation of VSMC proliferation - downregulation of vascular smooth muscle cell proliferation - negative regulation of VSMC proliferation - negative regulation of vascular smooth muscle cell proliferation - inhibition of VSMC proliferation - inhibition of vascular smooth muscle cell proliferation - biological_process - GO:1904706 - negative regulation of vascular associated smooth muscle cell proliferation - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:23246467 - - - - - down regulation of VSMC proliferation - GOC:TermGenie - - - - - down regulation of vascular smooth muscle cell proliferation - GOC:TermGenie - - - - - down-regulation of VSMC proliferation - GOC:TermGenie - - - - - down-regulation of vascular smooth muscle cell proliferation - GOC:TermGenie - - - - - downregulation of VSMC proliferation - GOC:TermGenie - - - - - downregulation of vascular smooth muscle cell proliferation - GOC:TermGenie - - - - - negative regulation of VSMC proliferation - GOC:TermGenie - - - - - inhibition of VSMC proliferation - GOC:TermGenie - - - - - inhibition of vascular smooth muscle cell proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation. - sl - 2015-10-01T16:05:32Z - positive regulation of VSMC proliferation - positive regulation of vascular smooth muscle cell proliferation - up regulation of VSMC proliferation - up regulation of vascular smooth muscle cell proliferation - up-regulation of VSMC proliferation - up-regulation of vascular smooth muscle cell proliferation - upregulation of VSMC proliferation - upregulation of vascular smooth muscle cell proliferation - activation of VSMC proliferation - activation of vascular smooth muscle cell proliferation - biological_process - GO:1904707 - positive regulation of vascular associated smooth muscle cell proliferation - - - - - Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:23246467 - - - - - positive regulation of VSMC proliferation - GOC:TermGenie - - - - - up regulation of VSMC proliferation - GOC:TermGenie - - - - - up regulation of vascular smooth muscle cell proliferation - GOC:TermGenie - - - - - up-regulation of VSMC proliferation - GOC:TermGenie - - - - - up-regulation of vascular smooth muscle cell proliferation - GOC:TermGenie - - - - - upregulation of VSMC proliferation - GOC:TermGenie - - - - - upregulation of vascular smooth muscle cell proliferation - GOC:TermGenie - - - - - activation of VSMC proliferation - GOC:TermGenie - - - - - activation of vascular smooth muscle cell proliferation - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development. - es - 2015-10-19T14:12:27Z - down regulation of apoptotic cell death involved in anatomical structure development - down regulation of apoptotic cell death involved in development of an anatomical structure - down regulation of apoptotic process involved in anatomical structure development - down regulation of apoptotic process involved in development - down regulation of apoptotic process involved in development of an anatomical structure - down regulation of apoptotic programmed cell death involved in anatomical structure development - down regulation of apoptotic programmed cell death involved in development of an anatomical structure - down regulation of programmed cell death by apoptosis involved in anatomical structure development - down regulation of programmed cell death by apoptosis involved in development of an anatomical structure - down-regulation of apoptotic cell death involved in anatomical structure development - down-regulation of apoptotic cell death involved in development of an anatomical structure - down-regulation of apoptotic process involved in anatomical structure development - down-regulation of apoptotic process involved in development - down-regulation of apoptotic process involved in development of an anatomical structure - down-regulation of apoptotic programmed cell death involved in anatomical structure development - down-regulation of apoptotic programmed cell death involved in development of an anatomical structure - down-regulation of programmed cell death by apoptosis involved in anatomical structure development - down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure - downregulation of apoptotic cell death involved in anatomical structure development - downregulation of apoptotic cell death involved in development of an anatomical structure - downregulation of apoptotic process involved in anatomical structure development - downregulation of apoptotic process involved in development - downregulation of apoptotic process involved in development of an anatomical structure - downregulation of apoptotic programmed cell death involved in anatomical structure development - downregulation of apoptotic programmed cell death involved in development of an anatomical structure - downregulation of programmed cell death by apoptosis involved in anatomical structure development - downregulation of programmed cell death by apoptosis involved in development of an anatomical structure - negative regulation of apoptotic cell death involved in anatomical structure development - negative regulation of apoptotic cell death involved in development of an anatomical structure - negative regulation of apoptotic process involved in anatomical structure development - negative regulation of apoptotic process involved in development of an anatomical structure - negative regulation of apoptotic programmed cell death involved in anatomical structure development - negative regulation of apoptotic programmed cell death involved in development of an anatomical structure - negative regulation of programmed cell death by apoptosis involved in anatomical structure development - negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure - down regulation of activation of apoptosis involved in anatomical structure development - down regulation of activation of apoptosis involved in development of an anatomical structure - down regulation of apoptosis involved in anatomical structure development - down regulation of apoptosis involved in development of an anatomical structure - down regulation of apoptosis signaling involved in anatomical structure development - down regulation of apoptosis signaling involved in development of an anatomical structure - down regulation of apoptotic program involved in anatomical structure development - down regulation of apoptotic program involved in development of an anatomical structure - down regulation of type I programmed cell death involved in anatomical structure development - down regulation of type I programmed cell death involved in development of an anatomical structure - down-regulation of activation of apoptosis involved in anatomical structure development - down-regulation of activation of apoptosis involved in development of an anatomical structure - down-regulation of apoptosis involved in anatomical structure development - down-regulation of apoptosis involved in development of an anatomical structure - down-regulation of apoptosis signaling involved in anatomical structure development - down-regulation of apoptosis signaling involved in development of an anatomical structure - down-regulation of apoptotic program involved in anatomical structure development - down-regulation of apoptotic program involved in development of an anatomical structure - down-regulation of type I programmed cell death involved in anatomical structure development - down-regulation of type I programmed cell death involved in development of an anatomical structure - downregulation of activation of apoptosis involved in anatomical structure development - downregulation of activation of apoptosis involved in development of an anatomical structure - downregulation of apoptosis involved in anatomical structure development - downregulation of apoptosis involved in development of an anatomical structure - downregulation of apoptosis signaling involved in anatomical structure development - downregulation of apoptosis signaling involved in development of an anatomical structure - downregulation of apoptotic program involved in anatomical structure development - downregulation of apoptotic program involved in development of an anatomical structure - downregulation of type I programmed cell death involved in anatomical structure development - downregulation of type I programmed cell death involved in development of an anatomical structure - inhibition of activation of apoptosis involved in anatomical structure development - inhibition of activation of apoptosis involved in development of an anatomical structure - inhibition of apoptosis involved in anatomical structure development - inhibition of apoptosis involved in development of an anatomical structure - inhibition of apoptosis signaling involved in anatomical structure development - inhibition of apoptosis signaling involved in development of an anatomical structure - inhibition of apoptotic cell death involved in anatomical structure development - inhibition of apoptotic cell death involved in development of an anatomical structure - inhibition of apoptotic process involved in anatomical structure development - inhibition of apoptotic process involved in development - inhibition of apoptotic process involved in development of an anatomical structure - inhibition of apoptotic program involved in anatomical structure development - inhibition of apoptotic program involved in development of an anatomical structure - inhibition of apoptotic programmed cell death involved in anatomical structure development - inhibition of apoptotic programmed cell death involved in development of an anatomical structure - inhibition of programmed cell death by apoptosis involved in anatomical structure development - inhibition of programmed cell death by apoptosis involved in development of an anatomical structure - inhibition of type I programmed cell death involved in anatomical structure development - inhibition of type I programmed cell death involved in development of an anatomical structure - negative regulation of activation of apoptosis involved in anatomical structure development - negative regulation of activation of apoptosis involved in development of an anatomical structure - negative regulation of apoptosis involved in anatomical structure development - negative regulation of apoptosis involved in development of an anatomical structure - negative regulation of apoptosis signaling involved in anatomical structure development - negative regulation of apoptosis signaling involved in development of an anatomical structure - negative regulation of apoptotic program involved in anatomical structure development - negative regulation of apoptotic program involved in development of an anatomical structure - negative regulation of type I programmed cell death involved in anatomical structure development - negative regulation of type I programmed cell death involved in development of an anatomical structure - biological_process - down regulation of apoptosis activator activity involved in anatomical structure development - down regulation of apoptosis activator activity involved in development of an anatomical structure - down regulation of commitment to apoptosis involved in anatomical structure development - down regulation of commitment to apoptosis involved in development of an anatomical structure - down regulation of induction of apoptosis by p53 involved in anatomical structure development - down regulation of induction of apoptosis by p53 involved in development of an anatomical structure - down regulation of induction of apoptosis involved in anatomical structure development - down regulation of induction of apoptosis involved in development of an anatomical structure - down regulation of signaling (initiator) caspase activity involved in anatomical structure development - down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure - down-regulation of apoptosis activator activity involved in anatomical structure development - down-regulation of apoptosis activator activity involved in development of an anatomical structure - down-regulation of commitment to apoptosis involved in anatomical structure development - down-regulation of commitment to apoptosis involved in development of an anatomical structure - down-regulation of induction of apoptosis by p53 involved in anatomical structure development - down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure - down-regulation of induction of apoptosis involved in anatomical structure development - down-regulation of induction of apoptosis involved in development of an anatomical structure - down-regulation of signaling (initiator) caspase activity involved in anatomical structure development - down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure - downregulation of apoptosis activator activity involved in anatomical structure development - downregulation of apoptosis activator activity involved in development of an anatomical structure - downregulation of commitment to apoptosis involved in anatomical structure development - downregulation of commitment to apoptosis involved in development of an anatomical structure - downregulation of induction of apoptosis by p53 involved in anatomical structure development - downregulation of induction of apoptosis by p53 involved in development of an anatomical structure - downregulation of induction of apoptosis involved in anatomical structure development - downregulation of induction of apoptosis involved in development of an anatomical structure - downregulation of signaling (initiator) caspase activity involved in anatomical structure development - downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure - inhibition of apoptosis activator activity involved in anatomical structure development - inhibition of apoptosis activator activity involved in development of an anatomical structure - inhibition of commitment to apoptosis involved in anatomical structure development - inhibition of commitment to apoptosis involved in development of an anatomical structure - inhibition of induction of apoptosis by p53 involved in anatomical structure development - inhibition of induction of apoptosis by p53 involved in development of an anatomical structure - inhibition of induction of apoptosis involved in anatomical structure development - inhibition of induction of apoptosis involved in development of an anatomical structure - inhibition of signaling (initiator) caspase activity involved in anatomical structure development - inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure - negative regulation of apoptosis activator activity involved in anatomical structure development - negative regulation of apoptosis activator activity involved in development of an anatomical structure - negative regulation of commitment to apoptosis involved in anatomical structure development - negative regulation of commitment to apoptosis involved in development of an anatomical structure - negative regulation of induction of apoptosis by p53 involved in anatomical structure development - negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure - negative regulation of induction of apoptosis involved in anatomical structure development - negative regulation of induction of apoptosis involved in development of an anatomical structure - negative regulation of signaling (initiator) caspase activity involved in anatomical structure development - negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure - GO:1904746 - U4PR86 in PMID:22801495 inferred from mutant phenotype - negative regulation of apoptotic process involved in development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development. - GOC:TermGenie - GO_REF:0000058 - PMID:22801495 - - - - - down regulation of apoptotic cell death involved in anatomical structure development - GOC:TermGenie - - - - - down regulation of apoptotic cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - down regulation of apoptotic process involved in anatomical structure development - GOC:TermGenie - - - - - down regulation of apoptotic process involved in development - GOC:TermGenie - - - - - down regulation of apoptotic process involved in development of an anatomical structure - GOC:TermGenie - - - - - down regulation of apoptotic programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - down regulation of apoptotic programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - down regulation of programmed cell death by apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - down regulation of programmed cell death by apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - down-regulation of apoptotic cell death involved in anatomical structure development - GOC:TermGenie - - - - - down-regulation of apoptotic cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - down-regulation of apoptotic process involved in anatomical structure development - GOC:TermGenie - - - - - down-regulation of apoptotic process involved in development - GOC:TermGenie - - - - - down-regulation of apoptotic process involved in development of an anatomical structure - GOC:TermGenie - - - - - down-regulation of apoptotic programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - down-regulation of apoptotic programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - down-regulation of programmed cell death by apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - downregulation of apoptotic cell death involved in anatomical structure development - GOC:TermGenie - - - - - downregulation of apoptotic cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - downregulation of apoptotic process involved in anatomical structure development - GOC:TermGenie - - - - - downregulation of apoptotic process involved in development - GOC:TermGenie - - - - - downregulation of apoptotic process involved in development of an anatomical structure - GOC:TermGenie - - - - - downregulation of apoptotic programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - downregulation of apoptotic programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - downregulation of programmed cell death by apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - downregulation of programmed cell death by apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - negative regulation of apoptotic cell death involved in anatomical structure development - GOC:TermGenie - - - - - negative regulation of apoptotic cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - negative regulation of apoptotic process involved in anatomical structure development - GOC:TermGenie - - - - - negative regulation of apoptotic process involved in development of an anatomical structure - GOC:TermGenie - - - - - negative regulation of apoptotic programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - negative regulation of apoptotic programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - negative regulation of programmed cell death by apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - down regulation of activation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - down regulation of activation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - down regulation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - down regulation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - down regulation of apoptosis signaling involved in anatomical structure development - GOC:TermGenie - - - - - down regulation of apoptosis signaling involved in development of an anatomical structure - GOC:TermGenie - - - - - down regulation of apoptotic program involved in anatomical structure development - GOC:TermGenie - - - - - down regulation of apoptotic program involved in development of an anatomical structure - GOC:TermGenie - - - - - down regulation of type I programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - down regulation of type I programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - down-regulation of activation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - down-regulation of activation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - down-regulation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - down-regulation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - down-regulation of apoptosis signaling involved in anatomical structure development - GOC:TermGenie - - - - - down-regulation of apoptosis signaling involved in development of an anatomical structure - GOC:TermGenie - - - - - down-regulation of apoptotic program involved in anatomical structure development - GOC:TermGenie - - - - - down-regulation of apoptotic program involved in development of an anatomical structure - GOC:TermGenie - - - - - down-regulation of type I programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - down-regulation of type I programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - downregulation of activation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - downregulation of activation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - downregulation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - downregulation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - downregulation of apoptosis signaling involved in anatomical structure development - GOC:TermGenie - - - - - downregulation of apoptosis signaling involved in development of an anatomical structure - GOC:TermGenie - - - - - downregulation of apoptotic program involved in anatomical structure development - GOC:TermGenie - - - - - downregulation of apoptotic program involved in development of an anatomical structure - GOC:TermGenie - - - - - downregulation of type I programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - downregulation of type I programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - inhibition of activation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - inhibition of activation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - inhibition of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - inhibition of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - inhibition of apoptosis signaling involved in anatomical structure development - GOC:TermGenie - - - - - inhibition of apoptosis signaling involved in development of an anatomical structure - GOC:TermGenie - - - - - inhibition of apoptotic cell death involved in anatomical structure development - GOC:TermGenie - - - - - inhibition of apoptotic cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - inhibition of apoptotic process involved in anatomical structure development - GOC:TermGenie - - - - - inhibition of apoptotic process involved in development - GOC:TermGenie - - - - - inhibition of apoptotic process involved in development of an anatomical structure - GOC:TermGenie - - - - - inhibition of apoptotic program involved in anatomical structure development - GOC:TermGenie - - - - - inhibition of apoptotic program involved in development of an anatomical structure - GOC:TermGenie - - - - - inhibition of apoptotic programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - inhibition of apoptotic programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - inhibition of programmed cell death by apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - inhibition of programmed cell death by apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - inhibition of type I programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - inhibition of type I programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - negative regulation of activation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - negative regulation of activation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - negative regulation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - negative regulation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - negative regulation of apoptosis signaling involved in anatomical structure development - GOC:TermGenie - - - - - negative regulation of apoptosis signaling involved in development of an anatomical structure - GOC:TermGenie - - - - - negative regulation of apoptotic program involved in anatomical structure development - GOC:TermGenie - - - - - negative regulation of apoptotic program involved in development of an anatomical structure - GOC:TermGenie - - - - - negative regulation of type I programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - negative regulation of type I programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - down regulation of apoptosis activator activity involved in anatomical structure development - GOC:TermGenie - - - - - down regulation of apoptosis activator activity involved in development of an anatomical structure - GOC:TermGenie - - - - - down regulation of commitment to apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - down regulation of commitment to apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - down regulation of induction of apoptosis by p53 involved in anatomical structure development - GOC:TermGenie - - - - - down regulation of induction of apoptosis by p53 involved in development of an anatomical structure - GOC:TermGenie - - - - - down regulation of induction of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - down regulation of induction of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - down regulation of signaling (initiator) caspase activity involved in anatomical structure development - GOC:TermGenie - - - - - down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure - GOC:TermGenie - - - - - down-regulation of apoptosis activator activity involved in anatomical structure development - GOC:TermGenie - - - - - down-regulation of apoptosis activator activity involved in development of an anatomical structure - GOC:TermGenie - - - - - down-regulation of commitment to apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - down-regulation of commitment to apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - down-regulation of induction of apoptosis by p53 involved in anatomical structure development - GOC:TermGenie - - - - - down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure - GOC:TermGenie - - - - - down-regulation of induction of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - down-regulation of induction of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - down-regulation of signaling (initiator) caspase activity involved in anatomical structure development - GOC:TermGenie - - - - - down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure - GOC:TermGenie - - - - - downregulation of apoptosis activator activity involved in anatomical structure development - GOC:TermGenie - - - - - downregulation of apoptosis activator activity involved in development of an anatomical structure - GOC:TermGenie - - - - - downregulation of commitment to apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - downregulation of commitment to apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - downregulation of induction of apoptosis by p53 involved in anatomical structure development - GOC:TermGenie - - - - - downregulation of induction of apoptosis by p53 involved in development of an anatomical structure - GOC:TermGenie - - - - - downregulation of induction of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - downregulation of induction of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - downregulation of signaling (initiator) caspase activity involved in anatomical structure development - GOC:TermGenie - - - - - downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure - GOC:TermGenie - - - - - inhibition of apoptosis activator activity involved in anatomical structure development - GOC:TermGenie - - - - - inhibition of apoptosis activator activity involved in development of an anatomical structure - GOC:TermGenie - - - - - inhibition of commitment to apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - inhibition of commitment to apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - inhibition of induction of apoptosis by p53 involved in anatomical structure development - GOC:TermGenie - - - - - inhibition of induction of apoptosis by p53 involved in development of an anatomical structure - GOC:TermGenie - - - - - inhibition of induction of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - inhibition of induction of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - inhibition of signaling (initiator) caspase activity involved in anatomical structure development - GOC:TermGenie - - - - - inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure - GOC:TermGenie - - - - - negative regulation of apoptosis activator activity involved in anatomical structure development - GOC:TermGenie - - - - - negative regulation of apoptosis activator activity involved in development of an anatomical structure - GOC:TermGenie - - - - - negative regulation of commitment to apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - negative regulation of commitment to apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - negative regulation of induction of apoptosis by p53 involved in anatomical structure development - GOC:TermGenie - - - - - negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure - GOC:TermGenie - - - - - negative regulation of induction of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - negative regulation of induction of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - negative regulation of signaling (initiator) caspase activity involved in anatomical structure development - GOC:TermGenie - - - - - negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development. - es - 2015-10-19T14:12:34Z - positive regulation of apoptotic cell death involved in anatomical structure development - positive regulation of apoptotic cell death involved in development of an anatomical structure - positive regulation of apoptotic process involved in anatomical structure development - positive regulation of apoptotic process involved in development of an anatomical structure - positive regulation of apoptotic programmed cell death involved in anatomical structure development - positive regulation of apoptotic programmed cell death involved in development of an anatomical structure - positive regulation of programmed cell death by apoptosis involved in anatomical structure development - positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure - up regulation of apoptotic cell death involved in anatomical structure development - up regulation of apoptotic cell death involved in development of an anatomical structure - up regulation of apoptotic process involved in anatomical structure development - up regulation of apoptotic process involved in development - up regulation of apoptotic process involved in development of an anatomical structure - up regulation of apoptotic programmed cell death involved in anatomical structure development - up regulation of apoptotic programmed cell death involved in development of an anatomical structure - up regulation of programmed cell death by apoptosis involved in anatomical structure development - up regulation of programmed cell death by apoptosis involved in development of an anatomical structure - up-regulation of apoptotic cell death involved in anatomical structure development - up-regulation of apoptotic cell death involved in development of an anatomical structure - up-regulation of apoptotic process involved in anatomical structure development - up-regulation of apoptotic process involved in development - up-regulation of apoptotic process involved in development of an anatomical structure - up-regulation of apoptotic programmed cell death involved in anatomical structure development - up-regulation of apoptotic programmed cell death involved in development of an anatomical structure - up-regulation of programmed cell death by apoptosis involved in anatomical structure development - up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure - upregulation of apoptotic cell death involved in anatomical structure development - upregulation of apoptotic cell death involved in development of an anatomical structure - upregulation of apoptotic process involved in anatomical structure development - upregulation of apoptotic process involved in development - upregulation of apoptotic process involved in development of an anatomical structure - upregulation of apoptotic programmed cell death involved in anatomical structure development - upregulation of apoptotic programmed cell death involved in development of an anatomical structure - upregulation of programmed cell death by apoptosis involved in anatomical structure development - upregulation of programmed cell death by apoptosis involved in development of an anatomical structure - activation of activation of apoptosis involved in anatomical structure development - activation of activation of apoptosis involved in development of an anatomical structure - activation of apoptosis involved in anatomical structure development - activation of apoptosis involved in development of an anatomical structure - activation of apoptosis signaling involved in anatomical structure development - activation of apoptosis signaling involved in development of an anatomical structure - activation of apoptotic cell death involved in anatomical structure development - activation of apoptotic cell death involved in development of an anatomical structure - activation of apoptotic process involved in anatomical structure development - activation of apoptotic process involved in development - activation of apoptotic process involved in development of an anatomical structure - activation of apoptotic program involved in anatomical structure development - activation of apoptotic program involved in development of an anatomical structure - activation of apoptotic programmed cell death involved in anatomical structure development - activation of apoptotic programmed cell death involved in development of an anatomical structure - activation of programmed cell death by apoptosis involved in anatomical structure development - activation of programmed cell death by apoptosis involved in development of an anatomical structure - activation of type I programmed cell death involved in anatomical structure development - activation of type I programmed cell death involved in development of an anatomical structure - positive regulation of activation of apoptosis involved in anatomical structure development - positive regulation of activation of apoptosis involved in development of an anatomical structure - positive regulation of apoptosis involved in anatomical structure development - positive regulation of apoptosis involved in development of an anatomical structure - positive regulation of apoptosis signaling involved in anatomical structure development - positive regulation of apoptosis signaling involved in development of an anatomical structure - positive regulation of apoptotic program involved in anatomical structure development - positive regulation of apoptotic program involved in development of an anatomical structure - positive regulation of type I programmed cell death involved in anatomical structure development - positive regulation of type I programmed cell death involved in development of an anatomical structure - up regulation of activation of apoptosis involved in anatomical structure development - up regulation of activation of apoptosis involved in development of an anatomical structure - up regulation of apoptosis involved in anatomical structure development - up regulation of apoptosis involved in development of an anatomical structure - up regulation of apoptosis signaling involved in anatomical structure development - up regulation of apoptosis signaling involved in development of an anatomical structure - up regulation of apoptotic program involved in anatomical structure development - up regulation of apoptotic program involved in development of an anatomical structure - up regulation of type I programmed cell death involved in anatomical structure development - up regulation of type I programmed cell death involved in development of an anatomical structure - up-regulation of activation of apoptosis involved in anatomical structure development - up-regulation of activation of apoptosis involved in development of an anatomical structure - up-regulation of apoptosis involved in anatomical structure development - up-regulation of apoptosis involved in development of an anatomical structure - up-regulation of apoptosis signaling involved in anatomical structure development - up-regulation of apoptosis signaling involved in development of an anatomical structure - up-regulation of apoptotic program involved in anatomical structure development - up-regulation of apoptotic program involved in development of an anatomical structure - up-regulation of type I programmed cell death involved in anatomical structure development - up-regulation of type I programmed cell death involved in development of an anatomical structure - upregulation of activation of apoptosis involved in anatomical structure development - upregulation of activation of apoptosis involved in development of an anatomical structure - upregulation of apoptosis involved in anatomical structure development - upregulation of apoptosis involved in development of an anatomical structure - upregulation of apoptosis signaling involved in anatomical structure development - upregulation of apoptosis signaling involved in development of an anatomical structure - upregulation of apoptotic program involved in anatomical structure development - upregulation of apoptotic program involved in development of an anatomical structure - upregulation of type I programmed cell death involved in anatomical structure development - upregulation of type I programmed cell death involved in development of an anatomical structure - biological_process - activation of apoptosis activator activity involved in anatomical structure development - activation of apoptosis activator activity involved in development of an anatomical structure - activation of commitment to apoptosis involved in anatomical structure development - activation of commitment to apoptosis involved in development of an anatomical structure - activation of induction of apoptosis by p53 involved in anatomical structure development - activation of induction of apoptosis by p53 involved in development of an anatomical structure - activation of induction of apoptosis involved in anatomical structure development - activation of induction of apoptosis involved in development of an anatomical structure - activation of signaling (initiator) caspase activity involved in anatomical structure development - activation of signaling (initiator) caspase activity involved in development of an anatomical structure - positive regulation of apoptosis activator activity involved in anatomical structure development - positive regulation of apoptosis activator activity involved in development of an anatomical structure - positive regulation of commitment to apoptosis involved in anatomical structure development - positive regulation of commitment to apoptosis involved in development of an anatomical structure - positive regulation of induction of apoptosis by p53 involved in anatomical structure development - positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure - positive regulation of induction of apoptosis involved in anatomical structure development - positive regulation of induction of apoptosis involved in development of an anatomical structure - positive regulation of signaling (initiator) caspase activity involved in anatomical structure development - positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure - up regulation of apoptosis activator activity involved in anatomical structure development - up regulation of apoptosis activator activity involved in development of an anatomical structure - up regulation of commitment to apoptosis involved in anatomical structure development - up regulation of commitment to apoptosis involved in development of an anatomical structure - up regulation of induction of apoptosis by p53 involved in anatomical structure development - up regulation of induction of apoptosis by p53 involved in development of an anatomical structure - up regulation of induction of apoptosis involved in anatomical structure development - up regulation of induction of apoptosis involved in development of an anatomical structure - up regulation of signaling (initiator) caspase activity involved in anatomical structure development - up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure - up-regulation of apoptosis activator activity involved in anatomical structure development - up-regulation of apoptosis activator activity involved in development of an anatomical structure - up-regulation of commitment to apoptosis involved in anatomical structure development - up-regulation of commitment to apoptosis involved in development of an anatomical structure - up-regulation of induction of apoptosis by p53 involved in anatomical structure development - up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure - up-regulation of induction of apoptosis involved in anatomical structure development - up-regulation of induction of apoptosis involved in development of an anatomical structure - up-regulation of signaling (initiator) caspase activity involved in anatomical structure development - up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure - upregulation of apoptosis activator activity involved in anatomical structure development - upregulation of apoptosis activator activity involved in development of an anatomical structure - upregulation of commitment to apoptosis involved in anatomical structure development - upregulation of commitment to apoptosis involved in development of an anatomical structure - upregulation of induction of apoptosis by p53 involved in anatomical structure development - upregulation of induction of apoptosis by p53 involved in development of an anatomical structure - upregulation of induction of apoptosis involved in anatomical structure development - upregulation of induction of apoptosis involved in development of an anatomical structure - upregulation of signaling (initiator) caspase activity involved in anatomical structure development - upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure - GO:1904747 - U4PR86 in PMID:22801495 inferred from mutant phenotype - positive regulation of apoptotic process involved in development - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development. - GOC:TermGenie - GO_REF:0000058 - PMID:22801495 - - - - - positive regulation of apoptotic cell death involved in anatomical structure development - GOC:TermGenie - - - - - positive regulation of apoptotic cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - positive regulation of apoptotic process involved in anatomical structure development - GOC:TermGenie - - - - - positive regulation of apoptotic process involved in development of an anatomical structure - GOC:TermGenie - - - - - positive regulation of apoptotic programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - positive regulation of apoptotic programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - positive regulation of programmed cell death by apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - up regulation of apoptotic cell death involved in anatomical structure development - GOC:TermGenie - - - - - up regulation of apoptotic cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - up regulation of apoptotic process involved in anatomical structure development - GOC:TermGenie - - - - - up regulation of apoptotic process involved in development - GOC:TermGenie - - - - - up regulation of apoptotic process involved in development of an anatomical structure - GOC:TermGenie - - - - - up regulation of apoptotic programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - up regulation of apoptotic programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - up regulation of programmed cell death by apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - up regulation of programmed cell death by apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - up-regulation of apoptotic cell death involved in anatomical structure development - GOC:TermGenie - - - - - up-regulation of apoptotic cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - up-regulation of apoptotic process involved in anatomical structure development - GOC:TermGenie - - - - - up-regulation of apoptotic process involved in development - GOC:TermGenie - - - - - up-regulation of apoptotic process involved in development of an anatomical structure - GOC:TermGenie - - - - - up-regulation of apoptotic programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - up-regulation of apoptotic programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - up-regulation of programmed cell death by apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - upregulation of apoptotic cell death involved in anatomical structure development - GOC:TermGenie - - - - - upregulation of apoptotic cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - upregulation of apoptotic process involved in anatomical structure development - GOC:TermGenie - - - - - upregulation of apoptotic process involved in development - GOC:TermGenie - - - - - upregulation of apoptotic process involved in development of an anatomical structure - GOC:TermGenie - - - - - upregulation of apoptotic programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - upregulation of apoptotic programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - upregulation of programmed cell death by apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - upregulation of programmed cell death by apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - activation of activation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - activation of activation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - activation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - activation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - activation of apoptosis signaling involved in anatomical structure development - GOC:TermGenie - - - - - activation of apoptosis signaling involved in development of an anatomical structure - GOC:TermGenie - - - - - activation of apoptotic cell death involved in anatomical structure development - GOC:TermGenie - - - - - activation of apoptotic cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - activation of apoptotic process involved in anatomical structure development - GOC:TermGenie - - - - - activation of apoptotic process involved in development - GOC:TermGenie - - - - - activation of apoptotic process involved in development of an anatomical structure - GOC:TermGenie - - - - - activation of apoptotic program involved in anatomical structure development - GOC:TermGenie - - - - - activation of apoptotic program involved in development of an anatomical structure - GOC:TermGenie - - - - - activation of apoptotic programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - activation of apoptotic programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - activation of programmed cell death by apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - activation of programmed cell death by apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - activation of type I programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - activation of type I programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - positive regulation of activation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - positive regulation of activation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - positive regulation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - positive regulation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - positive regulation of apoptosis signaling involved in anatomical structure development - GOC:TermGenie - - - - - positive regulation of apoptosis signaling involved in development of an anatomical structure - GOC:TermGenie - - - - - positive regulation of apoptotic program involved in anatomical structure development - GOC:TermGenie - - - - - positive regulation of apoptotic program involved in development of an anatomical structure - GOC:TermGenie - - - - - positive regulation of type I programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - positive regulation of type I programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - up regulation of activation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - up regulation of activation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - up regulation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - up regulation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - up regulation of apoptosis signaling involved in anatomical structure development - GOC:TermGenie - - - - - up regulation of apoptosis signaling involved in development of an anatomical structure - GOC:TermGenie - - - - - up regulation of apoptotic program involved in anatomical structure development - GOC:TermGenie - - - - - up regulation of apoptotic program involved in development of an anatomical structure - GOC:TermGenie - - - - - up regulation of type I programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - up regulation of type I programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - up-regulation of activation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - up-regulation of activation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - up-regulation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - up-regulation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - up-regulation of apoptosis signaling involved in anatomical structure development - GOC:TermGenie - - - - - up-regulation of apoptosis signaling involved in development of an anatomical structure - GOC:TermGenie - - - - - up-regulation of apoptotic program involved in anatomical structure development - GOC:TermGenie - - - - - up-regulation of apoptotic program involved in development of an anatomical structure - GOC:TermGenie - - - - - up-regulation of type I programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - up-regulation of type I programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - upregulation of activation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - upregulation of activation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - upregulation of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - upregulation of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - upregulation of apoptosis signaling involved in anatomical structure development - GOC:TermGenie - - - - - upregulation of apoptosis signaling involved in development of an anatomical structure - GOC:TermGenie - - - - - upregulation of apoptotic program involved in anatomical structure development - GOC:TermGenie - - - - - upregulation of apoptotic program involved in development of an anatomical structure - GOC:TermGenie - - - - - upregulation of type I programmed cell death involved in anatomical structure development - GOC:TermGenie - - - - - upregulation of type I programmed cell death involved in development of an anatomical structure - GOC:TermGenie - - - - - activation of apoptosis activator activity involved in anatomical structure development - GOC:TermGenie - - - - - activation of apoptosis activator activity involved in development of an anatomical structure - GOC:TermGenie - - - - - activation of commitment to apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - activation of commitment to apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - activation of induction of apoptosis by p53 involved in anatomical structure development - GOC:TermGenie - - - - - activation of induction of apoptosis by p53 involved in development of an anatomical structure - GOC:TermGenie - - - - - activation of induction of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - activation of induction of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - activation of signaling (initiator) caspase activity involved in anatomical structure development - GOC:TermGenie - - - - - activation of signaling (initiator) caspase activity involved in development of an anatomical structure - GOC:TermGenie - - - - - positive regulation of apoptosis activator activity involved in anatomical structure development - GOC:TermGenie - - - - - positive regulation of apoptosis activator activity involved in development of an anatomical structure - GOC:TermGenie - - - - - positive regulation of commitment to apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - positive regulation of commitment to apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - positive regulation of induction of apoptosis by p53 involved in anatomical structure development - GOC:TermGenie - - - - - positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure - GOC:TermGenie - - - - - positive regulation of induction of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - positive regulation of induction of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - positive regulation of signaling (initiator) caspase activity involved in anatomical structure development - GOC:TermGenie - - - - - positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure - GOC:TermGenie - - - - - up regulation of apoptosis activator activity involved in anatomical structure development - GOC:TermGenie - - - - - up regulation of apoptosis activator activity involved in development of an anatomical structure - GOC:TermGenie - - - - - up regulation of commitment to apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - up regulation of commitment to apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - up regulation of induction of apoptosis by p53 involved in anatomical structure development - GOC:TermGenie - - - - - up regulation of induction of apoptosis by p53 involved in development of an anatomical structure - GOC:TermGenie - - - - - up regulation of induction of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - up regulation of induction of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - up regulation of signaling (initiator) caspase activity involved in anatomical structure development - GOC:TermGenie - - - - - up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure - GOC:TermGenie - - - - - up-regulation of apoptosis activator activity involved in anatomical structure development - GOC:TermGenie - - - - - up-regulation of apoptosis activator activity involved in development of an anatomical structure - GOC:TermGenie - - - - - up-regulation of commitment to apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - up-regulation of commitment to apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - up-regulation of induction of apoptosis by p53 involved in anatomical structure development - GOC:TermGenie - - - - - up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure - GOC:TermGenie - - - - - up-regulation of induction of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - up-regulation of induction of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - up-regulation of signaling (initiator) caspase activity involved in anatomical structure development - GOC:TermGenie - - - - - up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure - GOC:TermGenie - - - - - upregulation of apoptosis activator activity involved in anatomical structure development - GOC:TermGenie - - - - - upregulation of apoptosis activator activity involved in development of an anatomical structure - GOC:TermGenie - - - - - upregulation of commitment to apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - upregulation of commitment to apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - upregulation of induction of apoptosis by p53 involved in anatomical structure development - GOC:TermGenie - - - - - upregulation of induction of apoptosis by p53 involved in development of an anatomical structure - GOC:TermGenie - - - - - upregulation of induction of apoptosis involved in anatomical structure development - GOC:TermGenie - - - - - upregulation of induction of apoptosis involved in development of an anatomical structure - GOC:TermGenie - - - - - upregulation of signaling (initiator) caspase activity involved in anatomical structure development - GOC:TermGenie - + The specific behavior of an organism that is associated with reproduction. + https://github.com/geneontology/go-ontology/issues/23491 + jl + 2012-09-19T16:01:37Z + GO:0033057 + GO:0044704 + GO:0044705 + reproductive behavior in a multicellular organism + reproductive behaviour + multi-organism reproductive behavior + multicellular organism reproductive behavior + biological_process + single-organism reproductive behavior + GO:0019098 + + reproductive behavior + - - - upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure - GOC:TermGenie + + + The specific behavior of an organism that is associated with reproduction. + GOC:jl + GOC:pr - + - + - + - - + - + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. + regulation of lipid metabolism + biological_process + GO:0019216 + regulation of lipid metabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. + GOC:go_curators + + + + + + + + + + + + + + + + + + + - - - - Any process that modulates the frequency, rate or extent of apoptotic process involved in development. - es - 2015-10-19T15:02:28Z - regulation of apoptotic cell death involved in anatomical structure development - regulation of apoptotic cell death involved in development of an anatomical structure - regulation of apoptotic process involved in anatomical structure development - regulation of apoptotic process involved in development of an anatomical structure - regulation of apoptotic programmed cell death involved in anatomical structure development - regulation of apoptotic programmed cell death involved in development of an anatomical structure - regulation of programmed cell death by apoptosis involved in anatomical structure development - regulation of programmed cell death by apoptosis involved in development of an anatomical structure - regulation of activation of apoptosis involved in anatomical structure development - regulation of activation of apoptosis involved in development of an anatomical structure - regulation of apoptosis involved in anatomical structure development - regulation of apoptosis involved in development of an anatomical structure - regulation of apoptosis signaling involved in anatomical structure development - regulation of apoptosis signaling involved in development of an anatomical structure - regulation of apoptotic program involved in anatomical structure development - regulation of apoptotic program involved in development of an anatomical structure - regulation of type I programmed cell death involved in anatomical structure development - regulation of type I programmed cell death involved in development of an anatomical structure + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. + regulation of steroid metabolism biological_process - regulation of apoptosis activator activity involved in anatomical structure development - regulation of apoptosis activator activity involved in development of an anatomical structure - regulation of commitment to apoptosis involved in anatomical structure development - regulation of commitment to apoptosis involved in development of an anatomical structure - regulation of induction of apoptosis by p53 involved in anatomical structure development - regulation of induction of apoptosis by p53 involved in development of an anatomical structure - regulation of induction of apoptosis involved in anatomical structure development - regulation of induction of apoptosis involved in development of an anatomical structure - regulation of signaling (initiator) caspase activity involved in anatomical structure development - regulation of signaling (initiator) caspase activity involved in development of an anatomical structure - GO:1904748 - Q10943 in PMID:22801495, inferred from mutant phenotype - regulation of apoptotic process involved in development - - - - - + GO:0019218 + regulation of steroid metabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + - + - - https://github.com/geneontology/go-ontology/issues/13926 - + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GO:0044246 + regulation of metabolism + regulation of multicellular organismal metabolic process + regulation of organismal metabolic process + biological_process + GO:0019222 + + regulation of metabolic process + - + - Any process that modulates the frequency, rate or extent of apoptotic process involved in development. - GOC:TermGenie - GO_REF:0000058 - PMID:22801495 + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GOC:go_curators - - - regulation of apoptotic cell death involved in anatomical structure development - GOC:TermGenie + + + regulation of organismal metabolic process + GOC:tb + + + + + + + + The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. + Wikipedia:Nociception + nociception + perception of physiological pain + biological_process + GO:0019233 + sensory perception of pain + - - - regulation of apoptotic cell death involved in development of an anatomical structure - GOC:TermGenie + + + The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. + GOC:curators + + + + + + + + The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. + hexose metabolism + biological_process + GO:0019318 + hexose metabolic process + - - - regulation of apoptotic process involved in anatomical structure development - GOC:TermGenie + + + The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. + ISBN:0198506732 + + + + + + + + The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). + carboxylic acid metabolism + biological_process + GO:0019752 + carboxylic acid metabolic process + - - - regulation of apoptotic process involved in development of an anatomical structure - GOC:TermGenie + + + The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). + ISBN:0198506732 + + + + + + + + + A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny. + A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid). + https://github.com/geneontology/go-ontology/issues/22929 + Wikipedia:Sexual_reproduction + biological_process + GO:0019953 + Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. + Sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. + sexual reproduction + - - - regulation of apoptotic programmed cell death involved in anatomical structure development - GOC:TermGenie + + + A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny. + GOC:jl + GOC:kmv + GOC:krc + GOC:tb + ISBN:0387520546 + Wikipedia:Sexual_reproduction - - - regulation of apoptotic programmed cell death involved in development of an anatomical structure - GOC:TermGenie + + + A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid). + Wikipedia:Sexual_reproduction + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. + biological_process + GO:0021915 + neural tube development + - - - regulation of programmed cell death by apoptosis involved in anatomical structure development - GOC:TermGenie + + + The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + + + + + + + + + + + + + + + + + + + + + + + + + + A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. + reproductive cellular process in multicellular organism + biological_process + GO:0022412 + cellular process involved in reproduction in multicellular organism + - - - regulation of programmed cell death by apoptosis involved in development of an anatomical structure - GOC:TermGenie + + + A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. + GOC:isa_complete + + + + + + + + + + + + + + + + + + + + + + + + + A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. + jl + 2012-09-19T15:56:06Z + GO:0044702 + biological_process + single organism reproductive process + GO:0022414 + + reproductive process + - - - regulation of activation of apoptosis involved in anatomical structure development - GOC:TermGenie + + + A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. + GOC:dph + GOC:isa_complete + + + + + + + + + + + + + + + + + + + + + + + + + A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + biological_process + GO:0022600 + + digestive system process + - - - regulation of activation of apoptosis involved in development of an anatomical structure - GOC:TermGenie + + + A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:isa_complete + GOC:jid + GOC:mtg_cardio + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. + regulation of morphogenesis + biological_process + GO:0022603 + regulation of anatomical structure morphogenesis + - - - regulation of apoptosis involved in anatomical structure development - GOC:TermGenie + + + Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of a signaling process. + 2010-02-16T09:30:50Z + biological_process + regulation of signaling process + regulation of signalling process + GO:0023051 + regulation of signaling + - - - regulation of apoptosis involved in development of an anatomical structure - GOC:TermGenie + + + Any process that modulates the frequency, rate or extent of a signaling process. + GOC:mtg_signal - - - regulation of apoptosis signaling involved in anatomical structure development - GOC:TermGenie + + + regulation of signaling process + GOC:bf - - - regulation of apoptosis signaling involved in development of an anatomical structure - GOC:TermGenie + + + regulation of signalling process + GOC:mah + + + + + + + + The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. + jl + 2010-02-16T09:30:50Z + GO:0023046 + GO:0044700 + biological signaling + signaling process + signalling + biological_process + signalling process + single organism signaling + GO:0023052 + + + + + + + + Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. + signaling + - - - regulation of apoptotic program involved in anatomical structure development - GOC:TermGenie + + + The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. + GOC:mtg_signal + GOC:mtg_signaling_feb11 + GOC:signaling - - - regulation of apoptotic program involved in development of an anatomical structure - GOC:TermGenie + + + signalling process + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. + 2010-02-16T09:30:50Z + positive regulation of signalling process + biological_process + positive regulation of signaling process + GO:0023056 + positive regulation of signaling + - - - regulation of type I programmed cell death involved in anatomical structure development - GOC:TermGenie + + + Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. + GOC:mtg_signal - - - regulation of type I programmed cell death involved in development of an anatomical structure - GOC:TermGenie + + + positive regulation of signalling process + GOC:mah - + - regulation of apoptosis activator activity involved in anatomical structure development - GOC:TermGenie + positive regulation of signaling process + GOC:bf + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. + 2010-02-16T09:30:50Z + biological_process + negative regulation of signaling process + negative regulation of signalling process + GO:0023057 + negative regulation of signaling + - - - regulation of apoptosis activator activity involved in development of an anatomical structure - GOC:TermGenie + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. + GOC:mtg_signal - + - regulation of commitment to apoptosis involved in anatomical structure development - GOC:TermGenie + negative regulation of signaling process + GOC:bf - + - regulation of commitment to apoptosis involved in development of an anatomical structure - GOC:TermGenie + negative regulation of signalling process + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. + 2010-02-16T09:30:50Z + signal secretion + biological_process + GO:0023061 + signal release + - - - regulation of induction of apoptosis by p53 involved in anatomical structure development - GOC:TermGenie + + + The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. + GOC:mtg_signal - - - regulation of induction of apoptosis by p53 involved in development of an anatomical structure - GOC:TermGenie + + + signal secretion + GOC:bf + + + + + + + + + + + + + + + + + + + + + + + + A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. + + Wikipedia:Cell_junction + cellular_component + GO:0030054 + + + + cell junction + - - - regulation of induction of apoptosis involved in anatomical structure development - GOC:TermGenie + + + A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. + GOC:aruk + GOC:bc + GOC:mah + ISBN:0198506732 + PMID:26820516 + PMID:28096264 + http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html + + + + + + + + + The regulated release of a peptide hormone from a cell. + biological_process + GO:0030072 + peptide hormone secretion + - - - regulation of induction of apoptosis involved in development of an anatomical structure - GOC:TermGenie + + + The regulated release of a peptide hormone from a cell. + GOC:mah + + + + + + + + + The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. + https://github.com/geneontology/go-ontology/issues/11255#issuecomment-426191045 + biological_process + GO:0030073 + insulin secretion + - - - regulation of signaling (initiator) caspase activity involved in anatomical structure development - GOC:TermGenie + + + The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. + GOC:mah + ISBN:0198506732 + + + + + + + + The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. + Wikipedia:Haematopoiesis + blood cell biosynthesis + blood cell formation + haemopoiesis + hematopoiesis + biological_process + GO:0030097 + hemopoiesis + - - - regulation of signaling (initiator) caspase activity involved in development of an anatomical structure - GOC:TermGenie + + + The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. + GOC:dgh + ISBN:0198506732 - + - + - + - + - + - Any process that modulates the frequency, rate or extent of protein localization to nucleolus. - nc - 2015-10-19T15:16:17Z - regulation of protein localisation in nucleolus - regulation of protein localisation to nucleolus - regulation of protein localization in nucleolus + Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + regulation of bone biosynthesis + regulation of bone formation biological_process - GO:1904749 - regulation of protein localization to nucleolus + GO:0030278 + regulation of ossification - + - Any process that modulates the frequency, rate or extent of protein localization to nucleolus. - GOC:BHF - GOC:BHF_telomere - GOC:TermGenie - GOC:nc - GO_REF:0000058 - PMID:24415760 - - - - - regulation of protein localisation in nucleolus - GOC:TermGenie - - - - - regulation of protein localisation to nucleolus - GOC:TermGenie - - - - - regulation of protein localization in nucleolus - GOC:TermGenie + Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + GOC:go_curators - + - + - + - - + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus. - nc - 2015-10-19T15:16:24Z - down regulation of protein localisation in nucleolus - down regulation of protein localisation to nucleolus - down regulation of protein localization in nucleolus - down regulation of protein localization to nucleolus - down-regulation of protein localisation in nucleolus - down-regulation of protein localisation to nucleolus - down-regulation of protein localization in nucleolus - down-regulation of protein localization to nucleolus - downregulation of protein localisation in nucleolus - downregulation of protein localisation to nucleolus - downregulation of protein localization in nucleolus - downregulation of protein localization to nucleolus - negative regulation of protein localisation in nucleolus - negative regulation of protein localisation to nucleolus - negative regulation of protein localization in nucleolus - inhibition of protein localisation in nucleolus - inhibition of protein localisation to nucleolus - inhibition of protein localization in nucleolus - inhibition of protein localization to nucleolus + Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + down regulation of ossification + down-regulation of ossification + downregulation of ossification + negative regulation of bone biosynthesis + negative regulation of bone formation + inhibition of ossification biological_process - GO:1904750 - negative regulation of protein localization to nucleolus + GO:0030279 + negative regulation of ossification - + - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus. - GOC:BHF - GOC:BHF_telomere - GOC:TermGenie - GOC:nc - GO_REF:0000058 - PMID:24415760 - - - - - down regulation of protein localisation in nucleolus - GOC:TermGenie - - - - - down regulation of protein localisation to nucleolus - GOC:TermGenie - - - - - down regulation of protein localization in nucleolus - GOC:TermGenie - - - - - down regulation of protein localization to nucleolus - GOC:TermGenie - - - - - down-regulation of protein localisation in nucleolus - GOC:TermGenie - - - - - down-regulation of protein localisation to nucleolus - GOC:TermGenie - - - - - down-regulation of protein localization in nucleolus - GOC:TermGenie - - - - - down-regulation of protein localization to nucleolus - GOC:TermGenie - - - - - downregulation of protein localisation in nucleolus - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space. + cellular_component + GO:0030312 + + + + + + The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'. + external encapsulating structure + - - - downregulation of protein localisation to nucleolus - GOC:TermGenie + + + A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of cell migration. + biological_process + GO:0030334 + regulation of cell migration + - - - downregulation of protein localization in nucleolus - GOC:TermGenie + + + Any process that modulates the frequency, rate or extent of cell migration. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of cell migration. + up regulation of cell migration + up-regulation of cell migration + upregulation of cell migration + activation of cell migration + stimulation of cell migration + biological_process + GO:0030335 + positive regulation of cell migration + - - - downregulation of protein localization to nucleolus - GOC:TermGenie + + + Any process that activates or increases the frequency, rate or extent of cell migration. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. + down regulation of cell migration + down-regulation of cell migration + downregulation of cell migration + inhibition of cell migration + biological_process + GO:0030336 + negative regulation of cell migration + - - - negative regulation of protein localisation in nucleolus - GOC:TermGenie + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. + GOC:go_curators + + + + + + + + + The expulsion of feces from the rectum. + Wikipedia:Defecation + biological_process + GO:0030421 + defecation + - - - negative regulation of protein localisation to nucleolus - GOC:TermGenie + + + The expulsion of feces from the rectum. + GOC:mah + + + + + + + + A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. + Wikipedia:Peristalsis + biological_process + GO:0030432 + peristalsis + - - - negative regulation of protein localization in nucleolus - GOC:TermGenie + + + A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + The lipid bilayer surrounding a cytoplasmic vesicle. + cellular_component + GO:0030659 + cytoplasmic vesicle membrane + - - - inhibition of protein localisation in nucleolus - GOC:TermGenie + + + The lipid bilayer surrounding a cytoplasmic vesicle. + GOC:mah + + + + + + + + A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. + GO:0005578 + NIF_Subcellular:nlx_subcell_20090513 + Wikipedia:Extracellular_matrix + proteinaceous extracellular matrix + matrisome + cellular_component + GO:0031012 + + + + + + extracellular matrix + - - - inhibition of protein localisation to nucleolus - GOC:TermGenie + + + A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. + GOC:BHF + GOC:mah + GOC:rph + NIF_Subcellular:nlx_subcell_20090513 + PMID:21123617 + PMID:28089324 + + + + + + + + + + + + + + + + + + + + + + + + + A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. + NIF_Subcellular:sao830981606 + cellular_component + intracellular membrane + GO:0031090 + organelle membrane + - - - inhibition of protein localization in nucleolus - GOC:TermGenie + + + A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. + GOC:dos + GOC:mah - - - inhibition of protein localization to nucleolus - GOC:TermGenie + + + intracellular membrane + NIF_Subcellular:sao830981606 - + - + - - + + - - + + - - + + - Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus. - nc - 2015-10-19T15:16:30Z - positive regulation of protein localisation in nucleolus - positive regulation of protein localisation to nucleolus - positive regulation of protein localization in nucleolus - up regulation of protein localisation in nucleolus - up regulation of protein localisation to nucleolus - up regulation of protein localization in nucleolus - up regulation of protein localization to nucleolus - up-regulation of protein localisation in nucleolus - up-regulation of protein localisation to nucleolus - up-regulation of protein localization in nucleolus - up-regulation of protein localization to nucleolus - upregulation of protein localisation in nucleolus - upregulation of protein localisation to nucleolus - upregulation of protein localization in nucleolus - upregulation of protein localization to nucleolus - activation of protein localisation in nucleolus - activation of protein localisation to nucleolus - activation of protein localization in nucleolus - activation of protein localization to nucleolus + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + regulation of cellular metabolism biological_process - GO:1904751 - positive regulation of protein localization to nucleolus + GO:0031323 + + regulation of cellular metabolic process - + - Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus. - GOC:BHF - GOC:BHF_telomere - GOC:TermGenie - GOC:nc - GO_REF:0000058 - PMID:24415760 - - - - - positive regulation of protein localisation in nucleolus - GOC:TermGenie - - - - - positive regulation of protein localisation to nucleolus - GOC:TermGenie - - - - - positive regulation of protein localization in nucleolus - GOC:TermGenie - - - - - up regulation of protein localisation in nucleolus - GOC:TermGenie - - - - - up regulation of protein localisation to nucleolus - GOC:TermGenie - - - - - up regulation of protein localization in nucleolus - GOC:TermGenie - - - - - up regulation of protein localization to nucleolus - GOC:TermGenie - - - - - up-regulation of protein localisation in nucleolus - GOC:TermGenie - - - - - up-regulation of protein localisation to nucleolus - GOC:TermGenie - - - - - up-regulation of protein localization in nucleolus - GOC:TermGenie - - - - - up-regulation of protein localization to nucleolus - GOC:TermGenie - - - - - upregulation of protein localisation in nucleolus - GOC:TermGenie - - - - - upregulation of protein localisation to nucleolus - GOC:TermGenie - - - - - upregulation of protein localization in nucleolus - GOC:TermGenie - - - - - upregulation of protein localization to nucleolus - GOC:TermGenie - - - - - activation of protein localisation in nucleolus - GOC:TermGenie - - - - - activation of protein localisation to nucleolus - GOC:TermGenie - - - - - activation of protein localization in nucleolus - GOC:TermGenie - - - - - activation of protein localization to nucleolus - GOC:TermGenie + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + GOC:mah - + - + - + - - + + - + + + - - + + - The developmental process by which an intramembranous bone is generated and organized. - dos - 2015-10-28T11:46:04Z + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + down regulation of cellular metabolic process + down-regulation of cellular metabolic process + downregulation of cellular metabolic process + negative regulation of cellular metabolism + inhibition of cellular metabolic process biological_process - intramembranous bones morphogenesis - membrane bone morphogenesis - GO:1904770 - intramembranous bone morphogenesis + GO:0031324 + + negative regulation of cellular metabolic process - + - The developmental process by which an intramembranous bone is generated and organized. - GOC:TermGenie - GO_REF:0000083 - PMID:26399686 - - - - - intramembranous bones morphogenesis - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + positive regulation of cellular metabolism + up regulation of cellular metabolic process + up-regulation of cellular metabolic process + upregulation of cellular metabolic process + activation of cellular metabolic process + stimulation of cellular metabolic process + biological_process + GO:0031325 + + positive regulation of cellular metabolic process + - - - membrane bone morphogenesis - GOC:TermGenie + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + GOC:mah - + - + - + - + + - + - Any process that modulates the frequency, rate or extent of protein localization to cell cortex. - es - 2015-10-29T16:55:01Z - regulation of protein localisation to cell cortex + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + regulation of cellular anabolism + regulation of cellular biosynthesis + regulation of cellular formation + regulation of cellular synthesis biological_process - GO:1904776 - An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. - regulation of protein localization to cell cortex + GO:0031326 + regulation of cellular biosynthetic process - + - Any process that modulates the frequency, rate or extent of protein localization to cell cortex. - GOC:TermGenie - GO_REF:0000058 - PMID:17115027 - - - - - regulation of protein localisation to cell cortex - GOC:TermGenie + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:mah - + - + - + - - + + + - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex. - es - 2015-10-29T16:55:08Z - down regulation of protein localisation to cell cortex - down regulation of protein localization to cell cortex - down-regulation of protein localisation to cell cortex - down-regulation of protein localization to cell cortex - downregulation of protein localisation to cell cortex - downregulation of protein localization to cell cortex - negative regulation of protein localisation to cell cortex - inhibition of protein localisation to cell cortex - inhibition of protein localization to cell cortex + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + down regulation of cellular biosynthetic process + down-regulation of cellular biosynthetic process + downregulation of cellular biosynthetic process + negative regulation of cellular anabolism + negative regulation of cellular biosynthesis + negative regulation of cellular formation + negative regulation of cellular synthesis + inhibition of cellular biosynthetic process biological_process - GO:1904777 - An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. - negative regulation of protein localization to cell cortex + GO:0031327 + negative regulation of cellular biosynthetic process - + - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex. - GOC:TermGenie - GO_REF:0000058 - PMID:17115027 - - - - - down regulation of protein localisation to cell cortex - GOC:TermGenie - - - - - down regulation of protein localization to cell cortex - GOC:TermGenie - - - - - down-regulation of protein localisation to cell cortex - GOC:TermGenie - - - - - down-regulation of protein localization to cell cortex - GOC:TermGenie - - - - - downregulation of protein localisation to cell cortex - GOC:TermGenie - - - - - downregulation of protein localization to cell cortex - GOC:TermGenie - - - - - negative regulation of protein localisation to cell cortex - GOC:TermGenie - - - - - inhibition of protein localisation to cell cortex - GOC:TermGenie - - - - - inhibition of protein localization to cell cortex - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:mah - + - + - + - - + + + - - - - Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex. - es - 2015-10-29T16:55:15Z - positive regulation of protein localisation to cell cortex - up regulation of protein localisation to cell cortex - up regulation of protein localization to cell cortex - up-regulation of protein localisation to cell cortex - up-regulation of protein localization to cell cortex - upregulation of protein localisation to cell cortex - upregulation of protein localization to cell cortex - activation of protein localisation to cell cortex - activation of protein localization to cell cortex + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + positive regulation of cellular anabolism + positive regulation of cellular biosynthesis + positive regulation of cellular formation + positive regulation of cellular synthesis + up regulation of cellular biosynthetic process + up-regulation of cellular biosynthetic process + upregulation of cellular biosynthetic process + activation of cellular biosynthetic process + stimulation of cellular biosynthetic process biological_process - GO:1904778 - An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. - positive regulation of protein localization to cell cortex + GO:0031328 + positive regulation of cellular biosynthetic process - + - Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex. - GOC:TermGenie - GO_REF:0000058 - PMID:17115027 - - - - - positive regulation of protein localisation to cell cortex - GOC:TermGenie - - - - - up regulation of protein localisation to cell cortex - GOC:TermGenie - - - - - up regulation of protein localization to cell cortex - GOC:TermGenie - - - - - up-regulation of protein localisation to cell cortex - GOC:TermGenie - - - - - up-regulation of protein localization to cell cortex - GOC:TermGenie - - - - - upregulation of protein localisation to cell cortex - GOC:TermGenie - - - - - upregulation of protein localization to cell cortex - GOC:TermGenie - - - - - activation of protein localisation to cell cortex - GOC:TermGenie - - - - - activation of protein localization to cell cortex - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:mah - + - + - + - - + + - + + - - + + - The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure. - dph - 2015-11-17T19:00:01Z - tunica serosa development - wall of serous sac development + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + regulation of cellular breakdown + regulation of cellular catabolism + regulation of cellular degradation biological_process - serosa development - GO:1904817 - serous membrane development + GO:0031329 + regulation of cellular catabolic process - + - The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure. - GOC:TermGenie - GOC:dph - GO_REF:0000094 - PMID:15840053 - - - - - tunica serosa development - GOC:TermGenie - - - - - wall of serous sac development - GOC:TermGenie - - - - - serosa development - GOC:TermGenie + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + GOC:mah - + - + - + - - + + - - - - - - - + + + - - + + - The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure. - dph - 2015-11-17T19:00:17Z + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + down regulation of cellular catabolic process + down-regulation of cellular catabolic process + downregulation of cellular catabolic process + negative regulation of cellular breakdown + negative regulation of cellular catabolism + negative regulation of cellular degradation + inhibition of cellular catabolic process biological_process - GO:1904818 - visceral peritoneum development + GO:0031330 + negative regulation of cellular catabolic process - + - The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure. - GOC:TermGenie - GOC:dph - GO_REF:0000094 - PMID:15840053 + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + GOC:mah - + - + - + - - + + - - - - - - - + + + - - + + - The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure. - dph - 2015-11-17T19:00:24Z - peritoneal cavity lining development + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + positive regulation of cellular breakdown + positive regulation of cellular catabolism + positive regulation of cellular degradation + up regulation of cellular catabolic process + up-regulation of cellular catabolic process + upregulation of cellular catabolic process + activation of cellular catabolic process + stimulation of cellular catabolic process biological_process - GO:1904819 - parietal peritoneum development + GO:0031331 + positive regulation of cellular catabolic process - + - The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure. - GOC:TermGenie - GOC:dph - GO_REF:0000094 - PMID:15840053 - - - - - peritoneal cavity lining development - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + GOC:mah - + - + - + - - + + - + - - + + - The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure. - dph - 2015-11-18T17:23:51Z - biological_process - peritonaeum development - GO:1904820 - peritoneum development + A vesicle found in the cytoplasm of a cell. + GO:0016023 + NIF_Subcellular:sao180601769 + cellular_component + cytoplasmic membrane bounded vesicle + cytoplasmic membrane-enclosed vesicle + cytoplasmic, membrane-bounded vesicle + GO:0031410 + + + + + + + cytoplasmic vesicle - + - The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure. - GOC:TermGenie - GOC:dph - GO_REF:0000094 - PMID:15840053 - - - - - peritonaeum development - GOC:TermGenie + A vesicle found in the cytoplasm of a cell. + GOC:ai + GOC:mah + GOC:vesicles - + - + - + - + - + - Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation. - rph - 2015-11-24T10:20:40Z + Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. + regulation of neurological process + regulation of neurological system process + regulation of neurophysiological process biological_process - GO:1904829 - regulation of aortic smooth muscle cell differentiation + GO:0031644 + regulation of nervous system process - + - Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:22034194 + Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. + GOC:dph + GOC:mah + GOC:tb + + + + + regulation of neurological process + GOC:dph + GOC:tb - + - + - + - - + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation. - rph - 2015-11-24T10:20:47Z - down regulation of aortic smooth muscle cell differentiation - down-regulation of aortic smooth muscle cell differentiation - downregulation of aortic smooth muscle cell differentiation - inhibition of aortic smooth muscle cell differentiation + Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. + down regulation of neurological process + down-regulation of neurological process + downregulation of neurological process + negative regulation of neurological process + negative regulation of neurological system process + negative regulation of neurophysiological process + inhibition of neurological process biological_process - GO:1904830 - negative regulation of aortic smooth muscle cell differentiation + GO:0031645 + negative regulation of nervous system process - + - Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:22034194 - - - - - down regulation of aortic smooth muscle cell differentiation - GOC:TermGenie - - - - - down-regulation of aortic smooth muscle cell differentiation - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. + GOC:dph + GOC:mah + GOC:tb - + - downregulation of aortic smooth muscle cell differentiation - GOC:TermGenie - - - - - inhibition of aortic smooth muscle cell differentiation - GOC:TermGenie + negative regulation of neurological process + GOC:dph + GOC:tb - + - + - + - - + + - + - Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation. - rph - 2015-11-24T10:20:54Z - up regulation of aortic smooth muscle cell differentiation - up-regulation of aortic smooth muscle cell differentiation - upregulation of aortic smooth muscle cell differentiation - activation of aortic smooth muscle cell differentiation + Any process that activates or increases the frequency, rate or extent of a neurophysiological process. + positive regulation of neurological process + positive regulation of neurological system process + positive regulation of neurophysiological process + up regulation of neurological process + up-regulation of neurological process + upregulation of neurological process + activation of neurological process + stimulation of neurological process biological_process - GO:1904831 - positive regulation of aortic smooth muscle cell differentiation + GO:0031646 + positive regulation of nervous system process - + - Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:22034194 - - - - - up regulation of aortic smooth muscle cell differentiation - GOC:TermGenie - - - - - up-regulation of aortic smooth muscle cell differentiation - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of a neurophysiological process. + GOC:dph + GOC:mah + GOC:tb - + - upregulation of aortic smooth muscle cell differentiation - GOC:TermGenie + positive regulation of neurological process + GOC:dph + GOC:tb + + + + + + + + Any small, fluid-filled, spherical organelle enclosed by membrane. + GO:0031988 + NIF_Subcellular:sao221389602 + Wikipedia:Vesicle_(biology) + cellular_component + membrane-bounded vesicle + membrane-enclosed vesicle + GO:0031982 + + vesicle + - - - activation of aortic smooth muscle cell differentiation - GOC:TermGenie + + + Any small, fluid-filled, spherical organelle enclosed by membrane. + GOC:mah + GOC:pz + GOC:vesicles - + - + - + - - + + - + - - + + - The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. - bf - 2016-01-07T13:45:06Z - cranial skeleton development - craniofacial development - osteocranium development + Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + locomotion during locomotory behaviour biological_process - cranium development - GO:1904888 - cranial skeletal system development + GO:0031987 + locomotion involved in locomotory behavior - + - The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. - GOC:PARL - GOC:TermGenie - GOC:bf - GO_REF:0000094 - PMID:11262227 - - - - - cranial skeleton development - GOC:TermGenie - - - - - craniofacial development - PMID:11262227 - - - - - osteocranium development - GOC:TermGenie + Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. + up regulation of insulin secretion + up-regulation of insulin secretion + upregulation of insulin secretion + activation of insulin secretion + stimulation of insulin secretion + biological_process + GO:0032024 + positive regulation of insulin secretion + - - - cranium development - GOC:TermGenie + + + Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. + GOC:mah - + - + - + - + - + - Any process that modulates the frequency, rate or extent of cell proliferation in midbrain. - bf - 2016-02-01T13:16:11Z - regulation of cell proliferation in mesencephalon + Any process that modulates the frequency, rate or extent of a response to an external stimulus. biological_process - regulation of mesencepahalic cell proliferation - GO:1904933 - regulation of cell proliferation in midbrain + GO:0032101 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + regulation of response to external stimulus - + - Any process that modulates the frequency, rate or extent of cell proliferation in midbrain. - GOC:PARL - GOC:TermGenie - GOC:bf - GO_REF:0000058 - PMID:18953410 - PMID:24431302 - - - - - regulation of cell proliferation in mesencephalon - GOC:TermGenie - - - - - regulation of mesencepahalic cell proliferation - GOC:TermGenie + Any process that modulates the frequency, rate or extent of a response to an external stimulus. + GOC:mah - + - + - + - - + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain. - bf - 2016-02-01T13:16:19Z - down regulation of cell proliferation in mesencephalon - down regulation of cell proliferation in midbrain - down-regulation of cell proliferation in mesencephalon - down-regulation of cell proliferation in midbrain - downregulation of cell proliferation in mesencephalon - downregulation of cell proliferation in midbrain - negative regulation of cell proliferation in mesencephalon - inhibition of cell proliferation in mesencephalon - inhibition of cell proliferation in midbrain + Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. + down regulation of response to external stimulus + down-regulation of response to external stimulus + downregulation of response to external stimulus + inhibition of response to external stimulus biological_process - down regulation of mesencepahalic cell proliferation - down-regulation of mesencepahalic cell proliferation - downregulation of mesencepahalic cell proliferation - inhibition of mesencepahalic cell proliferation - negative regulation of mesencepahalic cell proliferation - GO:1904934 - negative regulation of cell proliferation in midbrain + GO:0032102 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + negative regulation of response to external stimulus - + - Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain. - GOC:PARL - GOC:TermGenie - GOC:bf - GO_REF:0000058 - PMID:18953410 - PMID:24431302 - - - - - down regulation of cell proliferation in mesencephalon - GOC:TermGenie - - - - - down regulation of cell proliferation in midbrain - GOC:TermGenie - - - - - down-regulation of cell proliferation in mesencephalon - GOC:TermGenie - - - - - down-regulation of cell proliferation in midbrain - GOC:TermGenie - - - - - downregulation of cell proliferation in mesencephalon - GOC:TermGenie - - - - - downregulation of cell proliferation in midbrain - GOC:TermGenie - - - - - negative regulation of cell proliferation in mesencephalon - GOC:TermGenie - - - - - inhibition of cell proliferation in mesencephalon - GOC:TermGenie - - - - - inhibition of cell proliferation in midbrain - GOC:TermGenie - - - - - down regulation of mesencepahalic cell proliferation - GOC:TermGenie - - - - - down-regulation of mesencepahalic cell proliferation - GOC:TermGenie - - - - - downregulation of mesencepahalic cell proliferation - GOC:TermGenie - - - - - inhibition of mesencepahalic cell proliferation - GOC:TermGenie - - - - - negative regulation of mesencepahalic cell proliferation - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. + GOC:mah - + - + - + - - + + - + - Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain. - bf - 2016-02-01T13:16:27Z - positive regulation of cell proliferation in mesencephalon - up regulation of cell proliferation in mesencephalon - up regulation of cell proliferation in midbrain - up-regulation of cell proliferation in mesencephalon - up-regulation of cell proliferation in midbrain - upregulation of cell proliferation in mesencephalon - upregulation of cell proliferation in midbrain - activation of cell proliferation in mesencephalon - activation of cell proliferation in midbrain + Any process that activates, maintains or increases the rate of a response to an external stimulus. + up regulation of response to external stimulus + up-regulation of response to external stimulus + upregulation of response to external stimulus + activation of response to external stimulus + stimulation of response to external stimulus biological_process - activation of mesencepahalic cell proliferation - positive regulation of mesencepahalic cell proliferation - up regulation of mesencepahalic cell proliferation - up-regulation of mesencepahalic cell proliferation - upregulation of mesencepahalic cell proliferation - GO:1904935 - positive regulation of cell proliferation in midbrain + GO:0032103 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + positive regulation of response to external stimulus - + - Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain. - GOC:PARL - GOC:TermGenie - GOC:bf - GO_REF:0000058 - PMID:24431302 - - - - - positive regulation of cell proliferation in mesencephalon - GOC:TermGenie - - - - - up regulation of cell proliferation in mesencephalon - GOC:TermGenie - - - - - up regulation of cell proliferation in midbrain - GOC:TermGenie - - - - - up-regulation of cell proliferation in mesencephalon - GOC:TermGenie - - - - - up-regulation of cell proliferation in midbrain - GOC:TermGenie - - - - - upregulation of cell proliferation in mesencephalon - GOC:TermGenie - - - - - upregulation of cell proliferation in midbrain - GOC:TermGenie - - - - - activation of cell proliferation in mesencephalon - GOC:TermGenie - - - - - activation of cell proliferation in midbrain - GOC:TermGenie - - - - - activation of mesencepahalic cell proliferation - GOC:TermGenie - - - - - positive regulation of mesencepahalic cell proliferation - GOC:TermGenie - - - - - up regulation of mesencepahalic cell proliferation - GOC:TermGenie - - - - - up-regulation of mesencepahalic cell proliferation - GOC:TermGenie - - - - - upregulation of mesencepahalic cell proliferation - GOC:TermGenie + Any process that activates, maintains or increases the rate of a response to an external stimulus. + GOC:mah - + - + - + - + + - + - Any process that modulates the frequency, rate or extent of cardiac ventricle formation. - bc - 2016-02-02T16:37:16Z + Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. biological_process - GO:1904942 - regulation of cardiac ventricle formation + GO:0032368 + regulation of lipid transport - + - Any process that modulates the frequency, rate or extent of cardiac ventricle formation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:bc - GO_REF:0000058 - PMID:23575307 + Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah - + - + - + - - - - - - - - - + + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation. - bc - 2016-02-02T16:37:24Z - down regulation of cardiac ventricle formation - down-regulation of cardiac ventricle formation - downregulation of cardiac ventricle formation - inhibition of cardiac ventricle formation + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + down regulation of lipid transport + down-regulation of lipid transport + downregulation of lipid transport + inhibition of lipid transport biological_process - GO:1904943 - negative regulation of cardiac ventricle formation + GO:0032369 + negative regulation of lipid transport - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:bc - GO_REF:0000058 - PMID:23575307 - - - - - down regulation of cardiac ventricle formation - GOC:TermGenie - - - - - down-regulation of cardiac ventricle formation - GOC:TermGenie - - - - - downregulation of cardiac ventricle formation - GOC:TermGenie - - - - - inhibition of cardiac ventricle formation - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah - + - + - + - - + + + - + - Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation. - bc - 2016-02-02T16:37:31Z - up regulation of cardiac ventricle formation - up-regulation of cardiac ventricle formation - upregulation of cardiac ventricle formation - activation of cardiac ventricle formation + Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + up regulation of lipid transport + up-regulation of lipid transport + upregulation of lipid transport + activation of lipid transport + stimulation of lipid transport biological_process - GO:1904944 - positive regulation of cardiac ventricle formation + GO:0032370 + positive regulation of lipid transport - + - Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:bc - GO_REF:0000058 - PMID:23575307 - - - - - up regulation of cardiac ventricle formation - GOC:TermGenie - - - - - up-regulation of cardiac ventricle formation - GOC:TermGenie - - - - - upregulation of cardiac ventricle formation - GOC:TermGenie - - - - - activation of cardiac ventricle formation - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah - + - - - - - - - - - - - - - - + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. - mec - 2016-02-05T09:59:24Z - down regulation of establishment of protein localisation - down regulation of establishment of protein localization - down regulation of protein positioning - down regulation of protein recruitment - down-regulation of establishment of protein localisation - down-regulation of establishment of protein localization - down-regulation of protein positioning - down-regulation of protein recruitment - downregulation of establishment of protein localisation - downregulation of establishment of protein localization - downregulation of protein positioning - downregulation of protein recruitment - negative regulation of establishment of protein localisation - negative regulation of protein positioning - negative regulation of protein recruitment - inhibition of establishment of protein localisation - inhibition of establishment of protein localization - inhibition of protein positioning - inhibition of protein recruitment - biological_process - GO:1904950 - negative regulation of establishment of protein localization + + + + + + + An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. + GO:0000141 + GO:0030482 + cellular_component + actin cable + GO:0032432 + actin filament bundle - + - Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. - GOC:TermGenie - GO_REF:0000058 - PMID:22761445 - - - - - down regulation of establishment of protein localisation - GOC:TermGenie - - - - - down regulation of establishment of protein localization - GOC:TermGenie - - - - - down regulation of protein positioning - GOC:TermGenie - - - - - down regulation of protein recruitment - GOC:TermGenie - - - - - down-regulation of establishment of protein localisation - GOC:TermGenie - - - - - down-regulation of establishment of protein localization - GOC:TermGenie - - - - - down-regulation of protein positioning - GOC:TermGenie - - - - - down-regulation of protein recruitment - GOC:TermGenie - - - - - downregulation of establishment of protein localisation - GOC:TermGenie - - - - - downregulation of establishment of protein localization - GOC:TermGenie - - - - - downregulation of protein positioning - GOC:TermGenie - - - - - downregulation of protein recruitment - GOC:TermGenie - - - - - negative regulation of establishment of protein localisation - GOC:TermGenie - - - - - negative regulation of protein positioning - GOC:TermGenie + An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. + GOC:mah - - - negative regulation of protein recruitment - GOC:TermGenie + + + actin cable + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any biological process, occurring at the level of a multicellular organism, pertinent to its function. + + + + + jl + 2012-09-19T16:07:47Z + GO:0044707 + GO:0050874 + organismal physiological process + biological_process + single-multicellular organism process + GO:0032501 + + + multicellular organismal process + - - - inhibition of establishment of protein localisation - GOC:TermGenie + + + Any biological process, occurring at the level of a multicellular organism, pertinent to its function. + GOC:curators + GOC:dph + GOC:isa_complete + GOC:tb + + + + + + + + A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. + jl + 2012-12-19T12:21:31Z + GO:0044767 + development + biological_process + single-organism developmental process + GO:0032502 + + + + developmental process + - - - inhibition of establishment of protein localization - GOC:TermGenie + + + A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. + GOC:isa_complete + + + + + + + + + The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. + biological_process + GO:0032504 + + multicellular organism reproduction + - - - inhibition of protein positioning - GOC:TermGenie + + + The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. + GOC:isa_complete + GOC:jid + + + + + + + + The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). + monocarboxylate metabolic process + monocarboxylic acid metabolism + biological_process + GO:0032787 + + monocarboxylic acid metabolic process + - - - inhibition of protein recruitment - GOC:TermGenie + + + The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). + GOC:vk - + - + - + - - + + - - + - - + + - Any process that activates or increases the frequency, rate or extent of establishment of protein localization. - mec - 2016-02-05T09:59:32Z - positive regulation of establishment of protein localisation - positive regulation of protein positioning - positive regulation of protein recruitment - up regulation of establishment of protein localisation - up regulation of establishment of protein localization - up regulation of protein positioning - up regulation of protein recruitment - up-regulation of establishment of protein localisation - up-regulation of establishment of protein localization - up-regulation of protein positioning - up-regulation of protein recruitment - upregulation of establishment of protein localisation - upregulation of establishment of protein localization - upregulation of protein positioning - upregulation of protein recruitment - activation of establishment of protein localisation - activation of establishment of protein localization - activation of protein positioning - activation of protein recruitment - biological_process - GO:1904951 - positive regulation of establishment of protein localization + All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection. + cellular_component + GO:0032838 + plasma membrane bounded cell projection cytoplasm - + - Any process that activates or increases the frequency, rate or extent of establishment of protein localization. - GOC:TermGenie - GO_REF:0000058 - PMID:22761445 - - - - - positive regulation of establishment of protein localisation - GOC:TermGenie - - - - - positive regulation of protein positioning - GOC:TermGenie - - - - - positive regulation of protein recruitment - GOC:TermGenie - - - - - up regulation of establishment of protein localisation - GOC:TermGenie - - - - - up regulation of establishment of protein localization - GOC:TermGenie - - - - - up regulation of protein positioning - GOC:TermGenie - - - - - up regulation of protein recruitment - GOC:TermGenie - - - - - up-regulation of establishment of protein localisation - GOC:TermGenie - - - - - up-regulation of establishment of protein localization - GOC:TermGenie - - - - - up-regulation of protein positioning - GOC:TermGenie - - - - - up-regulation of protein recruitment - GOC:TermGenie - - - - - upregulation of establishment of protein localisation - GOC:TermGenie - - - - - upregulation of establishment of protein localization - GOC:TermGenie - - - - - upregulation of protein positioning - GOC:TermGenie - - - - - upregulation of protein recruitment - GOC:TermGenie - - - - - activation of establishment of protein localisation - GOC:TermGenie - - - - - activation of establishment of protein localization - GOC:TermGenie - - - - - activation of protein positioning - GOC:TermGenie - - - - - activation of protein recruitment - GOC:TermGenie + All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection. + GOC:krc + GOC:mah - + - + - - - - - + - - + + - - - - - - - - + - - + + - The process in which carboxylic acid is transported across a membrane. - vw - 2016-03-09T15:33:53Z + Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. + regulation of localisation biological_process - GO:1905039 - carboxylic acid transmembrane transport + GO:0032879 + regulation of localization - + - The process in which carboxylic acid is transported across a membrane. - GOC:TermGenie - GO_REF:0000069 - PMID:10869563 + Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. + GOC:mah + + + + + regulation of localisation + GOC:mah - + - + - + - + - + - Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation. - rph - 2016-03-21T11:14:53Z - regulation of VSMC differentiation - regulation of vascular smooth muscle cell differentiation + Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. + https://github.com/geneontology/go-ontology/issues/22021 + jl + 2015-01-20T14:32:14Z + GO:1903827 + regulation of cellular protein localisation + regulation of cellular protein localization + regulation of protein localisation biological_process - GO:1905063 - regulation of vascular associated smooth muscle cell differentiation + GO:0032880 + + regulation of protein localization - + - Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:19088079 + Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. + GOC:dph + GOC:mah + GOC:tb - + - regulation of VSMC differentiation - GOC:TermGenie + regulation of cellular protein localisation + GOC:TermGenie - + - regulation of vascular smooth muscle cell differentiation - GOC:TermGenie + regulation of protein localisation + GOC:mah - + - + - - + + - - + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation. - rph - 2016-03-21T11:15:03Z - down regulation of VSMC differentiation - down regulation of vascular associated smooth muscle cell differentiation - down regulation of vascular smooth muscle cell differentiation - down-regulation of VSMC differentiation - down-regulation of vascular associated smooth muscle cell differentiation - down-regulation of vascular smooth muscle cell differentiation - downregulation of VSMC differentiation - downregulation of vascular associated smooth muscle cell differentiation - downregulation of vascular smooth muscle cell differentiation - negative regulation of VSMC differentiation - negative regulation of vascular smooth muscle cell differentiation - inhibition of VSMC differentiation - inhibition of vascular associated smooth muscle cell differentiation - inhibition of vascular smooth muscle cell differentiation + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. biological_process - GO:1905064 - negative regulation of vascular associated smooth muscle cell differentiation + GO:0032881 + regulation of polysaccharide metabolic process - + - Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:19088079 - - - - - down regulation of VSMC differentiation - GOC:TermGenie - - - - - down regulation of vascular associated smooth muscle cell differentiation - GOC:TermGenie - - - - - down regulation of vascular smooth muscle cell differentiation - GOC:TermGenie - - - - - down-regulation of VSMC differentiation - GOC:TermGenie - - - - - down-regulation of vascular associated smooth muscle cell differentiation - GOC:TermGenie - - - - - down-regulation of vascular smooth muscle cell differentiation - GOC:TermGenie - - - - - downregulation of VSMC differentiation - GOC:TermGenie - - - - - downregulation of vascular associated smooth muscle cell differentiation - GOC:TermGenie - - - - - downregulation of vascular smooth muscle cell differentiation - GOC:TermGenie - - - - - negative regulation of VSMC differentiation - GOC:TermGenie - - - - - negative regulation of vascular smooth muscle cell differentiation - GOC:TermGenie - - - - - inhibition of VSMC differentiation - GOC:TermGenie - - - - - inhibition of vascular associated smooth muscle cell differentiation - GOC:TermGenie - - - - - inhibition of vascular smooth muscle cell differentiation - GOC:TermGenie + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. + GOC:mah - + - + - - + + - - + + + - - + + - Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation. - rph - 2016-03-21T11:15:13Z - positive regulation of VSMC differentiation - positive regulation of vascular smooth muscle cell differentiation - up regulation of VSMC differentiation - up regulation of vascular associated smooth muscle cell differentiation - up regulation of vascular smooth muscle cell differentiation - up-regulation of VSMC differentiation - up-regulation of vascular associated smooth muscle cell differentiation - up-regulation of vascular smooth muscle cell differentiation - upregulation of VSMC differentiation - upregulation of vascular associated smooth muscle cell differentiation - upregulation of vascular smooth muscle cell differentiation - activation of VSMC differentiation - activation of vascular associated smooth muscle cell differentiation - activation of vascular smooth muscle cell differentiation + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides. biological_process - GO:1905065 - positive regulation of vascular associated smooth muscle cell differentiation + GO:0032885 + regulation of polysaccharide biosynthetic process - + - Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:19088079 - - - - - positive regulation of VSMC differentiation - GOC:TermGenie - - - - - positive regulation of vascular smooth muscle cell differentiation - GOC:TermGenie - - - - - up regulation of VSMC differentiation - GOC:TermGenie - - - - - up regulation of vascular associated smooth muscle cell differentiation - GOC:TermGenie - - - - - up regulation of vascular smooth muscle cell differentiation - GOC:TermGenie - - - - - up-regulation of VSMC differentiation - GOC:TermGenie - - - - - up-regulation of vascular associated smooth muscle cell differentiation - GOC:TermGenie - - - - - up-regulation of vascular smooth muscle cell differentiation - GOC:TermGenie - - - - - upregulation of VSMC differentiation - GOC:TermGenie - - - - - upregulation of vascular associated smooth muscle cell differentiation - GOC:TermGenie - - - - - upregulation of vascular smooth muscle cell differentiation - GOC:TermGenie - - - - - activation of VSMC differentiation - GOC:TermGenie - - - - - activation of vascular associated smooth muscle cell differentiation - GOC:TermGenie - - - - - activation of vascular smooth muscle cell differentiation - GOC:TermGenie + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides. + GOC:mah - + - + - + - - + - + - Any process that modulates the frequency, rate or extent of axo-dendritic protein transport. - sl - 2016-04-11T20:38:31Z - regulation of axonal protein transport + Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. biological_process - GO:1905126 - regulation of axo-dendritic protein transport + GO:0032890 + regulation of organic acid transport - + - Any process that modulates the frequency, rate or extent of axo-dendritic protein transport. - GOC:TermGenie - GO_REF:0000058 - PMID:20694152 - - - - - regulation of axonal protein transport - GOC:TermGenie + Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah - + - + - + - - + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport. - sl - 2016-04-11T20:38:40Z - down regulation of axo-dendritic protein transport - down-regulation of axo-dendritic protein transport - downregulation of axo-dendritic protein transport - down regulation of axonal protein transport - down-regulation of axonal protein transport - downregulation of axonal protein transport - inhibition of axo-dendritic protein transport - inhibition of axonal protein transport - negative regulation of axonal protein transport + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + down regulation of organic acid transport + down-regulation of organic acid transport + downregulation of organic acid transport + inhibition of organic acid transport biological_process - GO:1905127 - negative regulation of axo-dendritic protein transport + GO:0032891 + negative regulation of organic acid transport - + - Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport. - GOC:TermGenie - GO_REF:0000058 - PMID:20694152 - - - - - down regulation of axo-dendritic protein transport - GOC:TermGenie - - - - - down-regulation of axo-dendritic protein transport - GOC:TermGenie - - - - - downregulation of axo-dendritic protein transport - GOC:TermGenie - - - - - down regulation of axonal protein transport - GOC:TermGenie - - - - - down-regulation of axonal protein transport - GOC:TermGenie - - - - - downregulation of axonal protein transport - GOC:TermGenie - - - - - inhibition of axo-dendritic protein transport - GOC:TermGenie - - - - - inhibition of axonal protein transport - GOC:TermGenie - - - - - negative regulation of axonal protein transport - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah - + - + - + - - + + - + - Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport. - sl - 2016-04-11T20:38:48Z - up regulation of axo-dendritic protein transport - up-regulation of axo-dendritic protein transport - upregulation of axo-dendritic protein transport - activation of axo-dendritic protein transport - activation of axonal protein transport - positive regulation of axonal protein transport - up regulation of axonal protein transport - up-regulation of axonal protein transport - upregulation of axonal protein transport + Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + up regulation of organic acid transport + up-regulation of organic acid transport + upregulation of organic acid transport + activation of organic acid transport + stimulation of organic acid transport biological_process - GO:1905128 - positive regulation of axo-dendritic protein transport + GO:0032892 + positive regulation of organic acid transport - + - Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport. - GOC:TermGenie - GO_REF:0000058 - PMID:20694152 - - - - - up regulation of axo-dendritic protein transport - GOC:TermGenie - - - - - up-regulation of axo-dendritic protein transport - GOC:TermGenie - - - - - upregulation of axo-dendritic protein transport - GOC:TermGenie - - - - - activation of axo-dendritic protein transport - GOC:TermGenie - - - - - activation of axonal protein transport - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + + + + + + + + + The controlled release of a substance by a cell. + Wikipedia:Secretion + cellular secretion + biological_process + GO:0032940 + secretion by cell + - - - positive regulation of axonal protein transport - GOC:TermGenie + + + The controlled release of a substance by a cell. + GOC:mah + + + + + + + + + The controlled release of a substance by a tissue. + tissue secretion + biological_process + expulsion of gland contents + GO:0032941 + secretion by tissue + - - - up regulation of axonal protein transport - GOC:TermGenie + + + The controlled release of a substance by a tissue. + GOC:mah - - - up-regulation of axonal protein transport - GOC:TermGenie + + + expulsion of gland contents + GOC:mah + + + + + + + + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. + GO:0043234 + macromolecular complex + macromolecule complex + protein containing complex + protein complex + protein-protein complex + cellular_component + GO:0032991 + + + + + + A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. + protein-containing complex + - - - upregulation of axonal protein transport - GOC:TermGenie + + + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. + GOC:dos + GOC:mah - + - - - - - - - - - - - - - - - - - - - - - - - - - - The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts. - dph - 2016-04-13T11:46:40Z - apical epidermal ridge formation + + + Any process in which a macromolecule is transported to, or maintained in, a specific location. + macromolecule localisation biological_process - AER formation - crista ectodermalis apicalis formation - GO:1905139 - apical ectodermal ridge formation + GO:0033036 + + macromolecule localization - + - The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts. - GOC:TermGenie - GO_REF:0000081 - PMID:18359901 - PMID:9323126 - PMID:9596583 + Any process in which a macromolecule is transported to, or maintained in, a specific location. + GOC:mah - + - apical epidermal ridge formation - GOC:TermGenie - - - - - AER formation - GOC:TermGenie - - - - - crista ectodermalis apicalis formation - GOC:TermGenie + macromolecule localisation + GOC:mah - + - + - - + + - - - - - - - + + + - - + + - Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation. - dph - 2016-04-13T12:16:40Z - regulation of apical epidermal ridge formation + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. + down regulation of catecholamine secretion + down-regulation of catecholamine secretion + downregulation of catecholamine secretion + inhibition of catecholamine secretion biological_process - regulation of AER formation - regulation of crista ectodermalis apicalis formation - GO:1905140 - regulation of apical ectodermal ridge formation + GO:0033604 + negative regulation of catecholamine secretion - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation. - GOC:TermGenie - GO_REF:0000058 - PMID:18359901 - - - - - regulation of apical epidermal ridge formation - GOC:TermGenie - - - - - regulation of AER formation - GOC:TermGenie - - - - - regulation of crista ectodermalis apicalis formation - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. + GOC:mah - + - + - - + + - - - - - - - - - + + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation. - dph - 2016-04-13T12:16:48Z - down regulation of apical ectodermal ridge formation - down regulation of apical epidermal ridge formation - down-regulation of apical ectodermal ridge formation - down-regulation of apical epidermal ridge formation - downregulation of apical ectodermal ridge formation - downregulation of apical epidermal ridge formation - negative regulation of apical epidermal ridge formation - inhibition of apical ectodermal ridge formation - inhibition of apical epidermal ridge formation + Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. + up regulation of catecholamine secretion + up-regulation of catecholamine secretion + upregulation of catecholamine secretion + activation of catecholamine secretion + stimulation of catecholamine secretion biological_process - down regulation of AER formation - down regulation of crista ectodermalis apicalis formation - down-regulation of AER formation - down-regulation of crista ectodermalis apicalis formation - downregulation of AER formation - downregulation of crista ectodermalis apicalis formation - inhibition of AER formation - inhibition of crista ectodermalis apicalis formation - negative regulation of AER formation - negative regulation of crista ectodermalis apicalis formation - GO:1905141 - negative regulation of apical ectodermal ridge formation - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - + GO:0033605 + positive regulation of catecholamine secretion + - + - Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation. - GOC:TermGenie - GO_REF:0000058 - PMID:18359901 + Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. + GOC:mah + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, occurring at the level of an individual cell. + cellular glycan biosynthesis + cellular glycan biosynthetic process + cellular polysaccharide anabolism + cellular polysaccharide biosynthesis + cellular polysaccharide formation + cellular polysaccharide synthesis + biological_process + GO:0033692 + cellular polysaccharide biosynthetic process + - - - down regulation of apical ectodermal ridge formation - GOC:TermGenie + + + The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, occurring at the level of an individual cell. + GOC:go_curators + + + + + + + + + + The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells. + biological_process + GO:0034637 + cellular carbohydrate biosynthetic process + - - - down regulation of apical epidermal ridge formation - GOC:TermGenie + + + The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells. + GOC:mah + + + + + + + + + + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. + GO:0034961 + cellular biopolymer biosynthetic process + cellular macromolecule anabolism + cellular macromolecule biosynthesis + cellular macromolecule formation + cellular macromolecule synthesis + biological_process + GO:0034645 + cellular macromolecule biosynthetic process + - - - down-regulation of apical ectodermal ridge formation - GOC:TermGenie + + + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. + GOC:mah - + - down-regulation of apical epidermal ridge formation - GOC:TermGenie + cellular biopolymer biosynthetic process + GOC:mtg_chebi_dec09 - + - downregulation of apical ectodermal ridge formation - GOC:TermGenie + cellular macromolecule anabolism + GOC:mah - + - downregulation of apical epidermal ridge formation - GOC:TermGenie + cellular macromolecule biosynthesis + GOC:mah - + - negative regulation of apical epidermal ridge formation - GOC:TermGenie - - - - - inhibition of apical ectodermal ridge formation - GOC:TermGenie - - - - - inhibition of apical epidermal ridge formation - GOC:TermGenie - - - - - down regulation of AER formation - GOC:TermGenie + cellular macromolecule formation + GOC:mah - - - down regulation of crista ectodermalis apicalis formation - GOC:TermGenie + + + cellular macromolecule synthesis + GOC:mah + + + + + + + + + + + + + + Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. + tube lumen formation + biological_process + lumen formation in an anatomical structure + GO:0035148 + tube formation + - - - down-regulation of AER formation - GOC:TermGenie + + + Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. + GOC:bf - - - down-regulation of crista ectodermalis apicalis formation - GOC:TermGenie + + + tube lumen formation + GOC:dph + GOC:mah - + - downregulation of AER formation - GOC:TermGenie + lumen formation in an anatomical structure + GOC:dph + GOC:mah + + + + + + + + + + + + + + The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + biological_process + GO:0035239 + tube morphogenesis + - - - downregulation of crista ectodermalis apicalis formation - GOC:TermGenie + + + The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + GOC:bf + PMID:14624839 + + + + + + + + + + + + + + The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. + biological_process + GO:0035295 + tube development + - - - inhibition of AER formation - GOC:TermGenie + + + The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. + PMID:12526790 + + + + + + + + + The directed movement of a protein to a specific location within the extracellular region. + bf + 2010-11-09T10:25:08Z + establishment of protein localisation in extracellular region + establishment of protein localization in extracellular region + biological_process + GO:0035592 + establishment of protein localization to extracellular region + - - - inhibition of crista ectodermalis apicalis formation - GOC:TermGenie + + + The directed movement of a protein to a specific location within the extracellular region. + GOC:BHF + GOC:bf - - - negative regulation of AER formation - GOC:TermGenie + + + establishment of protein localisation in extracellular region + GOC:mah + + + + + + + + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues. + bf + 2011-12-19T01:47:22Z + biological_process + GO:0036072 + direct ossification + - - - negative regulation of crista ectodermalis apicalis formation - GOC:TermGenie + + + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues. + GO_REF:0000034 - + - + - + - - + + - - - - - - - - - + + - - + + - Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation. - dph - 2016-04-13T12:16:57Z - positive regulation of apical epidermal ridge formation - up regulation of apical ectodermal ridge formation - up regulation of apical epidermal ridge formation - up-regulation of apical ectodermal ridge formation - up-regulation of apical epidermal ridge formation - upregulation of apical ectodermal ridge formation - upregulation of apical epidermal ridge formation - biological_process - activation of AER formation - positive regulation of AER formation - positive regulation of crista ectodermalis apicalis formation - up regulation of AER formation - up regulation of crista ectodermalis apicalis formation - up-regulation of AER formation - up-regulation of crista ectodermalis apicalis formation - upregulation of AER formation - upregulation of crista ectodermalis apicalis formation - GO:1905142 - positive regulation of apical ectodermal ridge formation + A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. + bf + 2012-04-20T10:20:47Z + myocyte projection + muscle arm + myopodia + cellular_component + GO:0036194 + muscle cell projection - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation. - GOC:TermGenie - GO_REF:0000058 - PMID:18359901 - - - - - positive regulation of apical epidermal ridge formation - GOC:TermGenie - - - - - up regulation of apical ectodermal ridge formation - GOC:TermGenie - - - - - up regulation of apical epidermal ridge formation - GOC:TermGenie - - - - - up-regulation of apical ectodermal ridge formation - GOC:TermGenie - - - - - up-regulation of apical epidermal ridge formation - GOC:TermGenie - - - - - upregulation of apical ectodermal ridge formation - GOC:TermGenie + A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. + CL:0000187 + GOC:kmv + PMID:15930100 + PMID:22464329 - + - upregulation of apical epidermal ridge formation - GOC:TermGenie - - - - - activation of AER formation - GOC:TermGenie - - - - - positive regulation of AER formation - GOC:TermGenie - - - - - positive regulation of crista ectodermalis apicalis formation - GOC:TermGenie - - - - - up regulation of AER formation - GOC:TermGenie - - - - - up regulation of crista ectodermalis apicalis formation - GOC:TermGenie - - - - - up-regulation of AER formation - GOC:TermGenie + myocyte projection + CL:0000187 - - - up-regulation of crista ectodermalis apicalis formation - GOC:TermGenie + + + muscle arm + GOC:kmv - - - upregulation of AER formation - GOC:TermGenie + + + myopodia + GOC:kmv + + + + + + + + + + + + + + The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. + bf + 2014-07-24T10:06:19Z + cellular_component + GO:0036477 + somatodendritic compartment + - - - upregulation of crista ectodermalis apicalis formation - GOC:TermGenie + + + The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. + GOC:PARL + GOC:pad - + - - - - - - - - - - - - - - - + + - - + + + + + + - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. - dos - 2016-04-14T08:54:49Z + + + + + + + Self-propelled movement of a cell or organism from one location to another. + biological_process - GO:1905144 - response to acetylcholine + GO:0040011 + + + + locomotion - + - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. - GOC:TermGenie - GO_REF:0000071 - PMID:21238497 + Self-propelled movement of a cell or organism from one location to another. + GOC:dgh - + - + - + - - + - + - Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy. - bc - 2016-04-15T12:47:07Z + Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. biological_process - GO:1905147 - regulation of smooth muscle hypertrophy + GO:0040012 + regulation of locomotion - + - Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:bc - GO_REF:0000058 - PMID:22161164 + Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. + GOC:ems - + - + - + - - - + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy. - bc - 2016-04-15T12:47:16Z - down regulation of smooth muscle hypertrophy - down-regulation of smooth muscle hypertrophy - downregulation of smooth muscle hypertrophy - inhibition of smooth muscle hypertrophy + Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. + down regulation of locomotion + down-regulation of locomotion + downregulation of locomotion + inhibition of locomotion biological_process - GO:1905148 - negative regulation of smooth muscle hypertrophy + GO:0040013 + negative regulation of locomotion - + - Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:bc - GO_REF:0000058 - PMID:22161164 - - - - - down regulation of smooth muscle hypertrophy - GOC:TermGenie - - - - - down-regulation of smooth muscle hypertrophy - GOC:TermGenie - - - - - downregulation of smooth muscle hypertrophy - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. + GOC:go_curators + + + + + + + + + + + + + + The first few specialized divisions of an activated animal egg. + biological_process + GO:0040016 + embryonic cleavage + - - - inhibition of smooth muscle hypertrophy - GOC:TermGenie + + + The first few specialized divisions of an activated animal egg. + GOC:clt + ISBN:0070524300 - + - + - + - - - + + - + - Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy. - bc - 2016-04-15T12:47:24Z - up regulation of smooth muscle hypertrophy - up-regulation of smooth muscle hypertrophy - upregulation of smooth muscle hypertrophy - activation of smooth muscle hypertrophy + Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. + up regulation of locomotion + up-regulation of locomotion + upregulation of locomotion + activation of locomotion + stimulation of locomotion biological_process - GO:1905149 - positive regulation of smooth muscle hypertrophy + GO:0040017 + positive regulation of locomotion - + - Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:bc - GO_REF:0000058 - PMID:22161164 - - - - - up regulation of smooth muscle hypertrophy - GOC:TermGenie - - - - - up-regulation of smooth muscle hypertrophy - GOC:TermGenie - - - - - upregulation of smooth muscle hypertrophy - GOC:TermGenie - - - - - activation of smooth muscle hypertrophy - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. + GOC:go_curators - + - + - - + + - + + + - - + + - Any process that modulates the frequency, rate or extent of cardiocyte differentiation. - bc - 2016-06-02T07:20:01Z - regulation of cardiac cell differentiation - regulation of heart cell differentiation + Any process that activates or increases the frequency, rate or extent of embryonic development. + up regulation of embryonic development + up-regulation of embryonic development + upregulation of embryonic development + activation of embryonic development + stimulation of embryonic development biological_process - GO:1905207 - regulation of cardiocyte differentiation + GO:0040019 + positive regulation of embryonic development - + - Any process that modulates the frequency, rate or extent of cardiocyte differentiation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:bc - GO_REF:0000058 - PMID:23069713 - - - - - regulation of cardiac cell differentiation - GOC:TermGenie - - - - - regulation of heart cell differentiation - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of embryonic development. + GOC:go_curators - + - + - + - - + + - - - + - - + + - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation. - bc - 2016-06-02T07:20:09Z - down regulation of cardiac cell differentiation - down regulation of cardiocyte differentiation - down regulation of heart cell differentiation - down-regulation of cardiac cell differentiation - down-regulation of cardiocyte differentiation - down-regulation of heart cell differentiation - downregulation of cardiac cell differentiation - downregulation of cardiocyte differentiation - downregulation of heart cell differentiation - negative regulation of cardiac cell differentiation - negative regulation of heart cell differentiation - inhibition of cardiac cell differentiation - inhibition of cardiocyte differentiation - inhibition of heart cell differentiation + The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). biological_process - GO:1905208 - negative regulation of cardiocyte differentiation + GO:0042074 + cell migration involved in gastrulation - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:bc - GO_REF:0000058 - PMID:23069713 - - - - - down regulation of cardiac cell differentiation - GOC:TermGenie - - - - - down regulation of cardiocyte differentiation - GOC:TermGenie - - - - - down regulation of heart cell differentiation - GOC:TermGenie - - - - - down-regulation of cardiac cell differentiation - GOC:TermGenie - - - - - down-regulation of cardiocyte differentiation - GOC:TermGenie - - - - - down-regulation of heart cell differentiation - GOC:TermGenie - - - - - downregulation of cardiac cell differentiation - GOC:TermGenie - - - - - downregulation of cardiocyte differentiation - GOC:TermGenie - - - - - downregulation of heart cell differentiation - GOC:TermGenie - - - - - negative regulation of cardiac cell differentiation - GOC:TermGenie - - - - - negative regulation of heart cell differentiation - GOC:TermGenie - - - - - inhibition of cardiac cell differentiation - GOC:TermGenie - - - - - inhibition of cardiocyte differentiation - GOC:TermGenie - - - - - inhibition of heart cell differentiation - GOC:TermGenie + The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). + GOC:jl + ISBN:0878932437 + http://www.cellmigration.org/ - + - + - - + + - - - + - - + + + + + + - - - - - Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation. - bc - 2016-06-02T07:20:16Z - positive regulation of cardiac cell differentiation - positive regulation of heart cell differentiation - up regulation of cardiac cell differentiation - up regulation of cardiocyte differentiation - up regulation of heart cell differentiation - up-regulation of cardiac cell differentiation - up-regulation of cardiocyte differentiation - up-regulation of heart cell differentiation - upregulation of cardiac cell differentiation - upregulation of cardiocyte differentiation - upregulation of heart cell differentiation - activation of cardiac cell differentiation - activation of cardiocyte differentiation - activation of heart cell differentiation - biological_process - GO:1905209 - positive regulation of cardiocyte differentiation - - - - - + + + + + - - + + - - https://github.com/geneontology/go-ontology/issues/13926 - + + Any process that modulates the frequency, rate or extent of cell proliferation. + + biological_process + regulation of cell proliferation + GO:0042127 + regulation of cell population proliferation + - + - Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:bc - GO_REF:0000058 - PMID:23069713 - - - - - positive regulation of cardiac cell differentiation - GOC:TermGenie - - - - - positive regulation of heart cell differentiation - GOC:TermGenie - - - - - up regulation of cardiac cell differentiation - GOC:TermGenie - - - - - up regulation of cardiocyte differentiation - GOC:TermGenie - - - - - up regulation of heart cell differentiation - GOC:TermGenie - - - - - up-regulation of cardiac cell differentiation - GOC:TermGenie - - - - - up-regulation of cardiocyte differentiation - GOC:TermGenie - - - - - up-regulation of heart cell differentiation - GOC:TermGenie - - - - - upregulation of cardiac cell differentiation - GOC:TermGenie - - - - - upregulation of cardiocyte differentiation - GOC:TermGenie - - - - - upregulation of heart cell differentiation - GOC:TermGenie + Any process that modulates the frequency, rate or extent of cell proliferation. + GOC:jl + + + + + + + + + + The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + ketone metabolism + biological_process + GO:0042180 + + cellular ketone metabolic process + - - - activation of cardiac cell differentiation - GOC:TermGenie + + + The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + GOC:jl + ISBN:0787650153 + + + + + + + + Any biological process involved in the maintenance of an internal steady state. + GO:0032844 + GO:0032845 + GO:0032846 + homeostasis + activation of homeostatic process + inhibition of homeostatic process + biological_process + negative regulation of homeostatic process + positive regulation of homeostatic process + regulation of homeostatic process + GO:0042592 + + + + homeostatic process + - - - activation of cardiocyte differentiation - GOC:TermGenie + + + Any biological process involved in the maintenance of an internal steady state. + GOC:jl + ISBN:0395825172 + + + + + + + + The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + biological_process + GO:0042886 + + amide transport + - - - activation of heart cell differentiation - GOC:TermGenie + + + The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + ISBN:0198506732 - + - - - - - - - - - - - - - - - + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation. - vw - 2016-06-03T08:41:08Z - biological_process - GO:1905213 - negative regulation of mitotic chromosome condensation + A prolongation or process extending from a cell, e.g. a flagellum or axon. + cell process + cellular process + cellular projection + cellular_component + GO:0042995 + + + + + + cell projection - + - Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation. - GOC:TermGenie - GO_REF:0000058 - PMID:23219725 + A prolongation or process extending from a cell, e.g. a flagellum or axon. + GOC:jl + http://www.cogsci.princeton.edu/~wn/ - + - + - + - - + + - + - - + + - The developmental process by which an epicardium is generated and organized. - rl - 2016-06-07T10:02:32Z - heart epicardium morphogenesis - visceral serous pericardium of heart morphogenesis - visceral serous pericardium proper morphogenesis - biological_process - pericardium visceral mesothelium morphogenesis - GO:1905223 - epicardium morphogenesis + + + + + + + + + + + + + + + + + A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. + + NIF_Subcellular:sao867568886 + neuron process + neuron protrusion + neuronal cell projection + neurite + cellular_component + nerve fiber + GO:0043005 + + neuron projection - + - The developmental process by which an epicardium is generated and organized. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000083 - PMID:18718461 - - - - - heart epicardium morphogenesis - GOC:TermGenie - - - - - visceral serous pericardium of heart morphogenesis - GOC:TermGenie + A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. + GOC:jl + http://www.cogsci.princeton.edu/~wn/ - + - visceral serous pericardium proper morphogenesis - GOC:TermGenie + neuron protrusion + NIF_Subcellular:sao250931889 - + - pericardium visceral mesothelium morphogenesis - GOC:TermGenie + nerve fiber + GOC:dph - + - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization. - https://github.com/geneontology/go-ontology/issues/22766 - pr - 2016-06-15T20:14:47Z - GO:0045798 - GO:1903309 - down regulation of chromatin organisation - down regulation of chromatin organization - down regulation of establishment or maintenance of chromatin architecture - down-regulation of chromatin organisation - down-regulation of chromatin organization - down-regulation of establishment or maintenance of chromatin architecture - downregulation of chromatin organisation - downregulation of chromatin organization - downregulation of establishment or maintenance of chromatin architecture - negative regulation of chromatin assembly/disassembly - negative regulation of chromatin organisation - negative regulation of establishment or maintenance of chromatin architecture - inhibition of chromatin assembly or disassembly - inhibition of chromatin organisation - inhibition of chromatin organization - inhibition of establishment or maintenance of chromatin architecture + + + The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. biological_process - down regulation of chromatin assembly or disassembly - down-regulation of chromatin assembly or disassembly - downregulation of chromatin assembly or disassembly - negative regulation of chromatin assembly or disassembly - negative regulation of chromatin modification - GO:1905268 - negative regulation of chromatin organization + GO:0043009 + chordate embryonic development - + - Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization. - GOC:TermGenie - GOC:pr - GOC:vw - GO_REF:0000058 - PMID:654321 - - - - - down regulation of chromatin organisation - GOC:TermGenie - - - - - down regulation of chromatin organization - GOC:TermGenie - - - - - down regulation of establishment or maintenance of chromatin architecture - GOC:TermGenie - - - - - down-regulation of chromatin organisation - GOC:TermGenie - - - - - down-regulation of chromatin organization - GOC:TermGenie - - - - - down-regulation of establishment or maintenance of chromatin architecture - GOC:TermGenie - - - - - downregulation of chromatin organisation - GOC:TermGenie - - - - - downregulation of chromatin organization - GOC:TermGenie - - - - - downregulation of establishment or maintenance of chromatin architecture - GOC:TermGenie - - - - - negative regulation of chromatin organisation - GOC:TermGenie - - - - - negative regulation of establishment or maintenance of chromatin architecture - GOC:TermGenie - - - - - inhibition of chromatin organisation - GOC:TermGenie - - - - - inhibition of chromatin organization - GOC:TermGenie - - - - - inhibition of establishment or maintenance of chromatin architecture - GOC:TermGenie + The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. + GOC:mtg_sensu - + - + - + - - + + - - + - - + + - - + + - Any process that activates or increases the frequency, rate or extent of chromatin organization. - https://github.com/geneontology/go-ontology/issues/22766 - pr - 2016-06-15T20:14:56Z - GO:0045799 - GO:1903310 - positive regulation of chromatin organisation - positive regulation of establishment or maintenance of chromatin architecture - up regulation of chromatin organisation - up regulation of chromatin organization - up regulation of establishment or maintenance of chromatin architecture - up-regulation of chromatin organisation - up-regulation of chromatin organization - up-regulation of establishment or maintenance of chromatin architecture - upregulation of chromatin assembly or disassembly - upregulation of chromatin organisation - upregulation of chromatin organization - upregulation of establishment or maintenance of chromatin architecture - activation of chromatin assembly or disassembly - activation of chromatin organisation - activation of chromatin organization - activation of establishment or maintenance of chromatin architecture - stimulation of chromatin assembly or disassembly - biological_process - positive regulation of chromatin assembly or disassembly - positive regulation of chromatin assembly/disassembly - positive regulation of chromatin modification - up regulation of chromatin assembly or disassembly - up-regulation of chromatin assembly or disassembly - GO:1905269 - positive regulation of chromatin organization + The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. + NIF_Subcellular:sao1044911821 + Wikipedia:Soma_(biology) + neuron cell body + neuronal cell soma + cellular_component + GO:0043025 + + Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. + neuronal cell body - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that activates or increases the frequency, rate or extent of chromatin organization. - GOC:TermGenie - GOC:pr - GOC:vw - GO_REF:0000058 - PMID:654321 - - - - - positive regulation of chromatin organisation - GOC:TermGenie - - - - - positive regulation of establishment or maintenance of chromatin architecture - GOC:TermGenie - - - - - up regulation of chromatin organisation - GOC:TermGenie - - - - - up regulation of chromatin organization - GOC:TermGenie - - - - - up regulation of establishment or maintenance of chromatin architecture - GOC:TermGenie - - - - - up-regulation of chromatin organisation - GOC:TermGenie - - - - - up-regulation of chromatin organization - GOC:TermGenie - - - - - up-regulation of establishment or maintenance of chromatin architecture - GOC:TermGenie - - - - - upregulation of chromatin organisation - GOC:TermGenie + The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. + GOC:go_curators + + + + + + + + The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GO:0043283 + GO:0044259 + biopolymer metabolic process + macromolecule metabolism + organismal macromolecule metabolism + multicellular organismal macromolecule metabolic process + biological_process + GO:0043170 + + macromolecule metabolic process + - - - upregulation of chromatin organization - GOC:TermGenie + + + The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:mah - + - upregulation of establishment or maintenance of chromatin architecture - GOC:TermGenie - - - - - activation of chromatin organisation - GOC:TermGenie - - - - - activation of chromatin organization - GOC:TermGenie - - - - - activation of establishment or maintenance of chromatin architecture - GOC:TermGenie + biopolymer metabolic process + GOC:mtg_chebi_dec09 - + - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of epithelial tube formation. - bhm - 2016-06-20T09:35:41Z - biological_process - GO:1905276 - An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). - regulation of epithelial tube formation + + + Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. + NIF_Subcellular:sao1539965131 + Wikipedia:Organelle + cellular_component + GO:0043226 + + + + + organelle - + - Any process that modulates the frequency, rate or extent of epithelial tube formation. - GOC:TermGenie - GOC:bhm - GO_REF:0000058 - PMID:25745997 + Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. + GOC:go_curators - + - + - + - - + + - - - + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation. - bhm - 2016-06-20T09:35:49Z - down regulation of epithelial tube formation - down-regulation of epithelial tube formation - downregulation of epithelial tube formation - inhibition of epithelial tube formation - biological_process - GO:1905277 - An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). - negative regulation of epithelial tube formation + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. + NIF_Subcellular:sao414196390 + membrane-enclosed organelle + cellular_component + GO:0043227 + membrane-bounded organelle - + - Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation. - GOC:TermGenie - GOC:bhm - GO_REF:0000058 - PMID:25745997 - - - - - down regulation of epithelial tube formation - GOC:TermGenie - - - - - down-regulation of epithelial tube formation - GOC:TermGenie - - - - - downregulation of epithelial tube formation - GOC:TermGenie + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. + GOC:go_curators + + + + + + + + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. + https://github.com/geneontology/go-ontology/issues/21881 + NIF_Subcellular:sao1456184038 + non-membrane-enclosed organelle + biological condensate + cellular_component + GO:0043228 + + non-membrane-bounded organelle + - - - inhibition of epithelial tube formation - GOC:TermGenie + + + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. + GOC:go_curators - + - + - + - - + + - - - + - - + + - Any process that activates or increases the frequency, rate or extent of epithelial tube formation. - bhm - 2016-06-20T09:35:57Z - up regulation of epithelial tube formation - up-regulation of epithelial tube formation - upregulation of epithelial tube formation - activation of epithelial tube formation - biological_process - GO:1905278 - An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). - positive regulation of epithelial tube formation + Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. + cellular_component + GO:0043229 + + intracellular organelle - + - Any process that activates or increases the frequency, rate or extent of epithelial tube formation. - GOC:TermGenie - GOC:bhm - GO_REF:0000058 - PMID:25745997 - - - - - up regulation of epithelial tube formation - GOC:TermGenie - - - - - up-regulation of epithelial tube formation - GOC:TermGenie - - - - - upregulation of epithelial tube formation - GOC:TermGenie - - - - - activation of epithelial tube formation - GOC:TermGenie + Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. + GOC:go_curators - + - + - + - - + + - + - - + + - Any apoptotic process in a vascular associated smooth muscle cell. - rph - 2016-06-23T13:24:20Z - VSMC apoptotic process - vascular smooth muscle cell apoptotic process - VSMC apoptosis - vascular associated smooth muscle cell apoptosis - vascular smooth muscle cell apoptosis - biological_process - GO:1905288 - vascular associated smooth muscle cell apoptotic process + Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi. + cellular_component + GO:0043230 + + extracellular organelle - + - Any apoptotic process in a vascular associated smooth muscle cell. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000085 - PMID:26493107 - - - - - VSMC apoptotic process - GOC:TermGenie - - - - - vascular smooth muscle cell apoptotic process - GOC:TermGenie - - - - - VSMC apoptosis - GOC:TermGenie - - - - - vascular associated smooth muscle cell apoptosis - GOC:TermGenie - - - - - vascular smooth muscle cell apoptosis - GOC:TermGenie + Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi. + GOC:jl + PMID:9914479 - + - + - + - - + + - + + - - + + - Any process that modulates the frequency, rate or extent of neural crest cell differentiation. - rl - 2016-06-28T15:02:01Z - biological_process - GO:1905292 - regulation of neural crest cell differentiation + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. + intracellular membrane-enclosed organelle + cellular_component + GO:0043231 + + intracellular membrane-bounded organelle - + - Any process that modulates the frequency, rate or extent of neural crest cell differentiation. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:15073157 + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. + GOC:go_curators - + - + - + - - + + - - - - - - - - - + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation. - rl - 2016-06-28T15:02:09Z - down regulation of neural crest cell differentiation - down-regulation of neural crest cell differentiation - downregulation of neural crest cell differentiation - inhibition of neural crest cell differentiation - biological_process - GO:1905293 - negative regulation of neural crest cell differentiation + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. + intracellular non-membrane-enclosed organelle + cellular_component + GO:0043232 + + intracellular non-membrane-bounded organelle - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:15073157 - - - - - down regulation of neural crest cell differentiation - GOC:TermGenie - - - - - down-regulation of neural crest cell differentiation - GOC:TermGenie - - - - - downregulation of neural crest cell differentiation - GOC:TermGenie - - - - - inhibition of neural crest cell differentiation - GOC:TermGenie + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. + GOC:go_curators - + - + - - + + - - - - - - - - - + + - - + + - Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation. - rl - 2016-06-28T15:02:16Z - up regulation of neural crest cell differentiation - up-regulation of neural crest cell differentiation - upregulation of neural crest cell differentiation - activation of neural crest cell differentiation + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. + regulation of carbohydrate anabolism + regulation of carbohydrate biosynthesis + regulation of carbohydrate formation + regulation of carbohydrate synthesis biological_process - GO:1905294 - positive regulation of neural crest cell differentiation + GO:0043255 + regulation of carbohydrate biosynthetic process - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:15073157 - - - - - up regulation of neural crest cell differentiation - GOC:TermGenie - - - - - up-regulation of neural crest cell differentiation - GOC:TermGenie - - - - - upregulation of neural crest cell differentiation - GOC:TermGenie - - - - - activation of neural crest cell differentiation - GOC:TermGenie + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. + GOC:jl - + - + - + - - + + - - - - - - - - + + - - + + - Any process that modulates the frequency, rate or extent of intestinal epithelial cell development. - rph - 2016-06-30T11:40:47Z - biological_process - GO:1905298 - regulation of intestinal epithelial cell development + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. + extracellular non-membrane-enclosed organelle + cellular_component + GO:0043264 + extracellular non-membrane-bounded organelle - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that modulates the frequency, rate or extent of intestinal epithelial cell development. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:23904268 + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. + GOC:jl - + - + - - + + - - - - - - - - - - - - - - - - + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development. - rph - 2016-06-30T11:40:55Z - down regulation of intestinal epithelial cell development - down-regulation of intestinal epithelial cell development - downregulation of intestinal epithelial cell development - inhibition of intestinal epithelial cell development + Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. biological_process - GO:1905299 - negative regulation of intestinal epithelial cell development + GO:0043269 + regulation of ion transport - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:23904268 - - - - - down regulation of intestinal epithelial cell development - GOC:TermGenie - - - - - down-regulation of intestinal epithelial cell development - GOC:TermGenie - - - - - downregulation of intestinal epithelial cell development - GOC:TermGenie - - - - - inhibition of intestinal epithelial cell development - GOC:TermGenie + Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl - + - + - + - - - + + - + + Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + up regulation of ion transport + up-regulation of ion transport + upregulation of ion transport + activation of ion transport + stimulation of ion transport + biological_process + GO:0043270 + positive regulation of ion transport + + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + + + + + + + + + + + + + + + + + + + + - - + + - Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development. - rph - 2016-06-30T11:41:02Z - up regulation of intestinal epithelial cell development - up-regulation of intestinal epithelial cell development - upregulation of intestinal epithelial cell development - activation of intestinal epithelial cell development + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + down regulation of ion transport + down-regulation of ion transport + downregulation of ion transport + inhibition of ion transport biological_process - GO:1905300 - positive regulation of intestinal epithelial cell development + GO:0043271 + negative regulation of ion transport - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:23904268 - - - - - up regulation of intestinal epithelial cell development - GOC:TermGenie - - - - - up-regulation of intestinal epithelial cell development - GOC:TermGenie - - - - - upregulation of intestinal epithelial cell development - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + + + + + + + + The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). + keto acid metabolic process + keto acid metabolism + ketoacid metabolic process + ketoacid metabolism + oxo acid metabolic process + oxo acid metabolism + oxoacid metabolism + biological_process + GO:0043436 + oxoacid metabolic process + - - - activation of intestinal epithelial cell development - GOC:TermGenie + + + The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). + Wikipedia:Oxyacid - + - + - + - - - - - - - - - - + - + - Any process that modulates the frequency, rate or extent of cardiac myofibril assembly. - rl - 2016-07-06T10:01:49Z - regulation of cardiac myofibril development - regulation of cardiac myofibril morphogenesis + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. biological_process - regulation of heart myofibril assembly - GO:1905304 - regulation of cardiac myofibril assembly + GO:0043467 + regulation of generation of precursor metabolites and energy - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that modulates the frequency, rate or extent of cardiac myofibril assembly. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:16151019 - - - - - regulation of cardiac myofibril development - GOC:TermGenie - - - - - regulation of cardiac myofibril morphogenesis - GOC:TermGenie - - - - - regulation of heart myofibril assembly - GOC:TermGenie + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. + GOC:jl - + - + - - + + - - - - - + + - - + + - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly. - rl - 2016-07-06T10:01:58Z - down regulation of cardiac myofibril assembly - down regulation of cardiac myofibril development - down regulation of cardiac myofibril morphogenesis - down-regulation of cardiac myofibril assembly - down-regulation of cardiac myofibril development - down-regulation of cardiac myofibril morphogenesis - downregulation of cardiac myofibril assembly - downregulation of cardiac myofibril development - downregulation of cardiac myofibril morphogenesis - negative regulation of cardiac myofibril development - negative regulation of cardiac myofibril morphogenesis - inhibition of cardiac myofibril assembly - inhibition of cardiac myofibril development - inhibition of cardiac myofibril morphogenesis + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. biological_process - down regulation of heart myofibril assembly - down-regulation of heart myofibril assembly - downregulation of heart myofibril assembly - inhibition of heart myofibril assembly - negative regulation of heart myofibril assembly - GO:1905305 - negative regulation of cardiac myofibril assembly + GO:0043470 + regulation of carbohydrate catabolic process - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:16151019 - - - - - down regulation of cardiac myofibril assembly - GOC:TermGenie - - - - - down regulation of cardiac myofibril development - GOC:TermGenie - - - - - down regulation of cardiac myofibril morphogenesis - GOC:TermGenie - - - - - down-regulation of cardiac myofibril assembly - GOC:TermGenie - - - - - down-regulation of cardiac myofibril development - GOC:TermGenie - - - - - down-regulation of cardiac myofibril morphogenesis - GOC:TermGenie - - - - - downregulation of cardiac myofibril assembly - GOC:TermGenie - - - - - downregulation of cardiac myofibril development - GOC:TermGenie - - - - - downregulation of cardiac myofibril morphogenesis - GOC:TermGenie - - - - - negative regulation of cardiac myofibril development - GOC:TermGenie - - - - - negative regulation of cardiac myofibril morphogenesis - GOC:TermGenie - - - - - inhibition of cardiac myofibril assembly - GOC:TermGenie - - - - - inhibition of cardiac myofibril development - GOC:TermGenie - - - - - inhibition of cardiac myofibril morphogenesis - GOC:TermGenie - - - - - down regulation of heart myofibril assembly - GOC:TermGenie - - - - - down-regulation of heart myofibril assembly - GOC:TermGenie - - - - - downregulation of heart myofibril assembly - GOC:TermGenie - - - - - inhibition of heart myofibril assembly - GOC:TermGenie - - - - - negative regulation of heart myofibril assembly - GOC:TermGenie + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. + GOC:mlg - + - + - - + + - - - - - + + + + - - - - - Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly. - rl - 2016-07-06T10:02:07Z - positive regulation of cardiac myofibril development - positive regulation of cardiac myofibril morphogenesis - up regulation of cardiac myofibril assembly - up regulation of cardiac myofibril development - up regulation of cardiac myofibril morphogenesis - up-regulation of cardiac myofibril assembly - up-regulation of cardiac myofibril development - up-regulation of cardiac myofibril morphogenesis - upregulation of cardiac myofibril assembly - upregulation of cardiac myofibril development - upregulation of cardiac myofibril morphogenesis - activation of cardiac myofibril assembly - activation of cardiac myofibril development - activation of cardiac myofibril morphogenesis + + + + + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells. biological_process - activation of heart myofibril assembly - positive regulation of heart myofibril assembly - up regulation of heart myofibril assembly - up-regulation of heart myofibril assembly - upregulation of heart myofibril assembly - GO:1905306 - positive regulation of cardiac myofibril assembly + GO:0043471 + regulation of cellular carbohydrate catabolic process - + - Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000058 - PMID:16151019 - - - - - positive regulation of cardiac myofibril development - GOC:TermGenie - - - - - positive regulation of cardiac myofibril morphogenesis - GOC:TermGenie - - - - - up regulation of cardiac myofibril assembly - GOC:TermGenie - - - - - up regulation of cardiac myofibril development - GOC:TermGenie - - - - - up regulation of cardiac myofibril morphogenesis - GOC:TermGenie - - - - - up-regulation of cardiac myofibril assembly - GOC:TermGenie - - - - - up-regulation of cardiac myofibril development - GOC:TermGenie - - - - - up-regulation of cardiac myofibril morphogenesis - GOC:TermGenie - - - - - upregulation of cardiac myofibril assembly - GOC:TermGenie - - - - - upregulation of cardiac myofibril development - GOC:TermGenie - - - - - upregulation of cardiac myofibril morphogenesis - GOC:TermGenie - - - - - activation of cardiac myofibril assembly - GOC:TermGenie - - - - - activation of cardiac myofibril development - GOC:TermGenie - - - - - activation of cardiac myofibril morphogenesis - GOC:TermGenie - - - - - activation of heart myofibril assembly - GOC:TermGenie - - - - - positive regulation of heart myofibril assembly - GOC:TermGenie - - - - - up regulation of heart myofibril assembly - GOC:TermGenie - - - - - up-regulation of heart myofibril assembly - GOC:TermGenie - - - - - upregulation of heart myofibril assembly - GOC:TermGenie + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells. + GOC:jl - + - + - + - - + + - + - - + + - Any cell proliferation that is involved in endocardial cushion morphogenesis. - rl - 2016-07-12T13:56:36Z + Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. biological_process - GO:1905315 - cell proliferation involved in endocardial cushion morphogenesis + GO:0043576 + regulation of respiratory gaseous exchange - + - Any cell proliferation that is involved in endocardial cushion morphogenesis. - GOC:BHF - GOC:TermGenie - GOC:rl - GO_REF:0000060 - PMID:20652948 + Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. + GOC:jl - + - + - + - + - + - Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. - bhm - 2016-07-22T07:13:49Z - regulation of epithelium morphogenesis + Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. biological_process - GO:1905330 - An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). - regulation of morphogenesis of an epithelium + GO:0043900 + regulation of multi-organism process - + - Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. - GOC:TermGenie - GOC:bhm - GO_REF:0000058 - PMID:25745997 + Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. + GOC:jl + + + + + + + + The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. + glucan metabolism + biological_process + GO:0044042 + glucan metabolic process + - - - regulation of epithelium morphogenesis - GOC:TermGenie + + + The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. + GOC:jl - + - + - - + + - - + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. - bhm - 2016-07-22T07:13:57Z - down regulation of epithelium morphogenesis - down regulation of morphogenesis of an epithelium - down-regulation of epithelium morphogenesis - down-regulation of morphogenesis of an epithelium - downregulation of epithelium morphogenesis - downregulation of morphogenesis of an epithelium - negative regulation of epithelium morphogenesis - inhibition of epithelium morphogenesis - inhibition of morphogenesis of an epithelium + Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. biological_process - GO:1905331 - An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). - negative regulation of morphogenesis of an epithelium + GO:0044057 + regulation of system process - + - Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. - GOC:TermGenie - GOC:bhm - GO_REF:0000058 - PMID:25745997 - - - - - down regulation of epithelium morphogenesis - GOC:TermGenie - - - - - down regulation of morphogenesis of an epithelium - GOC:TermGenie - - - - - down-regulation of epithelium morphogenesis - GOC:TermGenie - - - - - down-regulation of morphogenesis of an epithelium - GOC:TermGenie - - - - - downregulation of epithelium morphogenesis - GOC:TermGenie - - - - - downregulation of morphogenesis of an epithelium - GOC:TermGenie - - - - - negative regulation of epithelium morphogenesis - GOC:TermGenie - - - - - inhibition of epithelium morphogenesis - GOC:TermGenie - - - - - inhibition of morphogenesis of an epithelium - GOC:TermGenie + Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. + GOC:jl - + - + - - + + - - + - - + + - Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. - bhm - 2016-07-22T07:14:05Z - positive regulation of epithelium morphogenesis - up regulation of epithelium morphogenesis - up regulation of morphogenesis of an epithelium - up-regulation of epithelium morphogenesis - up-regulation of morphogenesis of an epithelium - upregulation of epithelium morphogenesis - upregulation of morphogenesis of an epithelium - activation of epithelium morphogenesis - activation of morphogenesis of an epithelium + Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. biological_process - GO:1905332 - An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). - positive regulation of morphogenesis of an epithelium + GO:0044058 + regulation of digestive system process - + - Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. - GOC:TermGenie - GOC:bhm - GO_REF:0000058 - PMID:25745997 - - - - - positive regulation of epithelium morphogenesis - GOC:TermGenie - - - - - up regulation of epithelium morphogenesis - GOC:TermGenie - - - - - up regulation of morphogenesis of an epithelium - GOC:TermGenie - - - - - up-regulation of epithelium morphogenesis - GOC:TermGenie - - - - - up-regulation of morphogenesis of an epithelium - GOC:TermGenie - - - - - upregulation of epithelium morphogenesis - GOC:TermGenie - - - - - upregulation of morphogenesis of an epithelium - GOC:TermGenie - - - - - activation of epithelium morphogenesis - GOC:TermGenie - - - - - activation of morphogenesis of an epithelium - GOC:TermGenie + Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:jl - + - + - + - - + + - - - - - - - + - - + + - The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone. - pr - 2016-08-04T14:49:43Z - cilial transition zone assembly - cilial transition zone formation - ciliary transition zone formation - cilium transition zone assembly - cilium transition zone formation + Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. + regulation of endocrine system process biological_process - GO:1905349 - ciliary transition zone assembly + GO:0044060 + regulation of endocrine process - + - The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone. - GOC:TermGenie - GOC:cilia - GO_REF:0000079 - PMID:21725307 - PMID:23644468 - PMID:24448408 - PMID:26595381 - PMID:26982032 - - - - - cilial transition zone assembly - GOC:TermGenie - - - - - cilial transition zone formation - GOC:TermGenie - - - - - ciliary transition zone formation - GOC:TermGenie - - - - - cilium transition zone assembly - GOC:TermGenie - - - - - cilium transition zone formation - GOC:TermGenie + Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. + GOC:jl - + - + - + - - + + - + + - - + + - A process in which a protein is transported to, or maintained in, a location within a presynapse. - dos - 2016-08-18T14:42:59Z - protein localisation in presynapse - protein localisation to presynapse - protein localization in presynapse - recruitment of presynaptic proteins + Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. biological_process - GO:1905383 - protein localization to presynapse + GO:0044062 + regulation of excretion - + - A process in which a protein is transported to, or maintained in, a location within a presynapse. - GOC:TermGenie - GO_REF:0000087 - PMID:24449494 - - - - - protein localisation in presynapse - GOC:TermGenie - - - - - protein localisation to presynapse - GOC:TermGenie - - - - - protein localization in presynapse - GOC:TermGenie - - - - - recruitment of presynaptic proteins - PMID:24449494 + Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. + GOC:jl - + - + - + - + + - + - Any process that modulates the frequency, rate or extent of protein localization to presynapse. - dos - 2016-08-18T14:56:00Z - regulation of protein localisation in presynapse - regulation of protein localisation to presynapse - regulation of protein localization in presynapse - regulation of recruitment of presynaptic proteins + Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. biological_process - GO:1905384 - regulation of protein localization to presynapse + GO:0044065 + regulation of respiratory system process - + - Any process that modulates the frequency, rate or extent of protein localization to presynapse. - GOC:PARL - GOC:TermGenie - GOC:bf - GO_REF:0000058 - PMID:24449494 - - - - - regulation of protein localisation in presynapse - GOC:TermGenie - - - - - regulation of protein localisation to presynapse - GOC:TermGenie - - - - - regulation of protein localization in presynapse - GOC:TermGenie - - - - - regulation of recruitment of presynaptic proteins - GOC:TermGenie + Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. + GOC:jl - + - + - - + + - - + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse. - dos - 2016-08-18T14:56:08Z - down regulation of protein localisation in presynapse - down regulation of protein localisation to presynapse - down regulation of protein localization in presynapse - down regulation of protein localization to presynapse - down regulation of recruitment of presynaptic proteins - down-regulation of protein localisation in presynapse - down-regulation of protein localisation to presynapse - down-regulation of protein localization in presynapse - down-regulation of protein localization to presynapse - down-regulation of recruitment of presynaptic proteins - downregulation of protein localisation in presynapse - downregulation of protein localisation to presynapse - downregulation of protein localization in presynapse - downregulation of protein localization to presynapse - downregulation of recruitment of presynaptic proteins - negative regulation of protein localisation in presynapse - negative regulation of protein localisation to presynapse - negative regulation of protein localization in presynapse - negative regulation of recruitment of presynaptic proteins - inhibition of protein localisation in presynapse - inhibition of protein localisation to presynapse - inhibition of protein localization in presynapse - inhibition of protein localization to presynapse - inhibition of recruitment of presynaptic proteins + Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. biological_process - GO:1905385 - negative regulation of protein localization to presynapse + GO:0044070 + regulation of anion transport - + - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse. - GOC:PARL - GOC:TermGenie - GOC:bf - GO_REF:0000058 - PMID:24449494 - - - - - down regulation of protein localisation in presynapse - GOC:TermGenie - - - - - down regulation of protein localisation to presynapse - GOC:TermGenie - - - - - down regulation of protein localization in presynapse - GOC:TermGenie - - - - - down regulation of protein localization to presynapse - GOC:TermGenie - - - - - down regulation of recruitment of presynaptic proteins - GOC:TermGenie - - - - - down-regulation of protein localisation in presynapse - GOC:TermGenie - - - - - down-regulation of protein localisation to presynapse - GOC:TermGenie - - - - - down-regulation of protein localization in presynapse - GOC:TermGenie - - - - - down-regulation of protein localization to presynapse - GOC:TermGenie - - - - - down-regulation of recruitment of presynaptic proteins - GOC:TermGenie - - - - - downregulation of protein localisation in presynapse - GOC:TermGenie - - - - - downregulation of protein localisation to presynapse - GOC:TermGenie - - - - - downregulation of protein localization in presynapse - GOC:TermGenie - - - - - downregulation of protein localization to presynapse - GOC:TermGenie - - - - - downregulation of recruitment of presynaptic proteins - GOC:TermGenie - - - - - negative regulation of protein localisation in presynapse - GOC:TermGenie - - - - - negative regulation of protein localisation to presynapse - GOC:TermGenie - - - - - negative regulation of protein localization in presynapse - GOC:TermGenie - - - - - negative regulation of recruitment of presynaptic proteins - GOC:TermGenie - - - - - inhibition of protein localisation in presynapse - GOC:TermGenie - - - - - inhibition of protein localisation to presynapse - GOC:TermGenie - - - - - inhibition of protein localization in presynapse - GOC:TermGenie - - - - - inhibition of protein localization to presynapse - GOC:TermGenie - - - - - inhibition of recruitment of presynaptic proteins - GOC:TermGenie + Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl - + - + - - + + - - + - - + + - Any process that activates or increases the frequency, rate or extent of protein localization to presynapse. - dos - 2016-08-18T14:56:21Z - positive regulation of protein localisation in presynapse - positive regulation of protein localisation to presynapse - positive regulation of protein localization in presynapse - positive regulation of recruitment of presynaptic proteins - up regulation of protein localisation in presynapse - up regulation of protein localisation to presynapse - up regulation of protein localization in presynapse - up regulation of protein localization to presynapse - up regulation of recruitment of presynaptic proteins - up-regulation of protein localisation in presynapse - up-regulation of protein localisation to presynapse - up-regulation of protein localization in presynapse - up-regulation of protein localization to presynapse - up-regulation of recruitment of presynaptic proteins - upregulation of protein localisation in presynapse - upregulation of protein localisation to presynapse - upregulation of protein localization in presynapse - upregulation of protein localization to presynapse - upregulation of recruitment of presynaptic proteins - activation of protein localisation in presynapse - activation of protein localisation to presynapse - activation of protein localization in presynapse - activation of protein localization to presynapse - activation of recruitment of presynaptic proteins + Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + jl + 2009-04-21T04:07:27Z biological_process - GO:1905386 - positive regulation of protein localization to presynapse + GO:0044092 + negative regulation of molecular function - + - Any process that activates or increases the frequency, rate or extent of protein localization to presynapse. - GOC:PARL - GOC:TermGenie - GOC:bf - GO_REF:0000058 - PMID:24449494 - - - - - positive regulation of protein localisation in presynapse - GOC:TermGenie - - - - - positive regulation of protein localisation to presynapse - GOC:TermGenie - - - - - positive regulation of protein localization in presynapse - GOC:TermGenie - - - - - positive regulation of recruitment of presynaptic proteins - GOC:TermGenie - - - - - up regulation of protein localisation in presynapse - GOC:TermGenie - - - - - up regulation of protein localisation to presynapse - GOC:TermGenie - - - - - up regulation of protein localization in presynapse - GOC:TermGenie - - - - - up regulation of protein localization to presynapse - GOC:TermGenie - - - - - up regulation of recruitment of presynaptic proteins - GOC:TermGenie - - - - - up-regulation of protein localisation in presynapse - GOC:TermGenie - - - - - up-regulation of protein localisation to presynapse - GOC:TermGenie - - - - - up-regulation of protein localization in presynapse - GOC:TermGenie - - - - - up-regulation of protein localization to presynapse - GOC:TermGenie - - - - - up-regulation of recruitment of presynaptic proteins - GOC:TermGenie - - - - - upregulation of protein localisation in presynapse - GOC:TermGenie - - - - - upregulation of protein localisation to presynapse - GOC:TermGenie - - - - - upregulation of protein localization in presynapse - GOC:TermGenie - - - - - upregulation of protein localization to presynapse - GOC:TermGenie - - - - - upregulation of recruitment of presynaptic proteins - GOC:TermGenie - - - - - activation of protein localisation in presynapse - GOC:TermGenie - - - - - activation of protein localisation to presynapse - GOC:TermGenie - - - - - activation of protein localization in presynapse - GOC:TermGenie - - - - - activation of protein localization to presynapse - GOC:TermGenie - - - - - activation of recruitment of presynaptic proteins - GOC:TermGenie + Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + GO:jl - + - + - + - - + + - + - - + + - Any intracellular signal transduction that is involved in positive regulation of cell growth. - dph - 2016-09-07T18:15:01Z - intracellular signal transduction involved in up regulation of cell growth - intracellular signal transduction involved in up-regulation of cell growth - intracellular signal transduction involved in upregulation of cell growth - intracellular signaling chain involved in positive regulation of cell growth - intracellular signaling chain involved in up regulation of cell growth - intracellular signaling chain involved in up-regulation of cell growth - intracellular signaling chain involved in upregulation of cell growth - intracellular protein kinase cascade involved in activation of cell growth - intracellular protein kinase cascade involved in positive regulation of cell growth - intracellular protein kinase cascade involved in stimulation of cell growth - intracellular protein kinase cascade involved in up regulation of cell growth - intracellular protein kinase cascade involved in up-regulation of cell growth - intracellular protein kinase cascade involved in upregulation of cell growth - intracellular signal transduction involved in activation of cell growth - intracellular signal transduction involved in stimulation of cell growth - intracellular signal transduction pathway involved in activation of cell growth - intracellular signal transduction pathway involved in positive regulation of cell growth - intracellular signal transduction pathway involved in stimulation of cell growth - intracellular signal transduction pathway involved in up regulation of cell growth - intracellular signal transduction pathway involved in up-regulation of cell growth - intracellular signal transduction pathway involved in upregulation of cell growth - intracellular signaling chain involved in activation of cell growth - intracellular signaling chain involved in stimulation of cell growth - protein kinase cascade involved in activation of cell growth - protein kinase cascade involved in positive regulation of cell growth - protein kinase cascade involved in stimulation of cell growth - protein kinase cascade involved in up regulation of cell growth - protein kinase cascade involved in up-regulation of cell growth - protein kinase cascade involved in upregulation of cell growth - signal transmission via intracellular cascade involved in activation of cell growth - signal transmission via intracellular cascade involved in positive regulation of cell growth - signal transmission via intracellular cascade involved in stimulation of cell growth - signal transmission via intracellular cascade involved in up regulation of cell growth - signal transmission via intracellular cascade involved in up-regulation of cell growth - signal transmission via intracellular cascade involved in upregulation of cell growth + Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + jl + 2009-04-21T04:11:06Z biological_process - intracellular signaling cascade involved in activation of cell growth - intracellular signaling cascade involved in positive regulation of cell growth - intracellular signaling cascade involved in stimulation of cell growth - intracellular signaling cascade involved in up regulation of cell growth - intracellular signaling cascade involved in up-regulation of cell growth - intracellular signaling cascade involved in upregulation of cell growth - intracellular signaling pathway involved in activation of cell growth - intracellular signaling pathway involved in positive regulation of cell growth - intracellular signaling pathway involved in stimulation of cell growth - intracellular signaling pathway involved in up regulation of cell growth - intracellular signaling pathway involved in up-regulation of cell growth - intracellular signaling pathway involved in upregulation of cell growth - signal transduction via intracellular signaling cascade involved in activation of cell growth - signal transduction via intracellular signaling cascade involved in positive regulation of cell growth - signal transduction via intracellular signaling cascade involved in stimulation of cell growth - signal transduction via intracellular signaling cascade involved in up regulation of cell growth - signal transduction via intracellular signaling cascade involved in up-regulation of cell growth - signal transduction via intracellular signaling cascade involved in upregulation of cell growth - GO:1905427 - intracellular signal transduction involved in positive regulation of cell growth + GO:0044093 + positive regulation of molecular function - + - Any intracellular signal transduction that is involved in positive regulation of cell growth. - GOC:TermGenie - GOC:al - GOC:vw - GO_REF:0000060 - PMID:15917811 - - - - - intracellular signal transduction involved in up regulation of cell growth - GOC:TermGenie - - - - - intracellular signal transduction involved in up-regulation of cell growth - GOC:TermGenie - - - - - intracellular signal transduction involved in upregulation of cell growth - GOC:TermGenie - - - - - intracellular signaling chain involved in positive regulation of cell growth - GOC:TermGenie - - - - - intracellular signaling chain involved in up regulation of cell growth - GOC:TermGenie - - - - - intracellular signaling chain involved in up-regulation of cell growth - GOC:TermGenie - - - - - intracellular signaling chain involved in upregulation of cell growth - GOC:TermGenie - - - - - intracellular protein kinase cascade involved in activation of cell growth - GOC:TermGenie - - - - - intracellular protein kinase cascade involved in positive regulation of cell growth - GOC:TermGenie - - - - - intracellular protein kinase cascade involved in stimulation of cell growth - GOC:TermGenie - - - - - intracellular protein kinase cascade involved in up regulation of cell growth - GOC:TermGenie - - - - - intracellular protein kinase cascade involved in up-regulation of cell growth - GOC:TermGenie - - - - - intracellular protein kinase cascade involved in upregulation of cell growth - GOC:TermGenie - - - - - intracellular signal transduction involved in activation of cell growth - GOC:TermGenie - - - - - intracellular signal transduction involved in stimulation of cell growth - GOC:TermGenie - - - - - intracellular signal transduction pathway involved in activation of cell growth - GOC:TermGenie - - - - - intracellular signal transduction pathway involved in positive regulation of cell growth - GOC:TermGenie - - - - - intracellular signal transduction pathway involved in stimulation of cell growth - GOC:TermGenie - - - - - intracellular signal transduction pathway involved in up regulation of cell growth - GOC:TermGenie - - - - - intracellular signal transduction pathway involved in up-regulation of cell growth - GOC:TermGenie - - - - - intracellular signal transduction pathway involved in upregulation of cell growth - GOC:TermGenie - - - - - intracellular signaling chain involved in activation of cell growth - GOC:TermGenie - - - - - intracellular signaling chain involved in stimulation of cell growth - GOC:TermGenie - - - - - protein kinase cascade involved in activation of cell growth - GOC:TermGenie - - - - - protein kinase cascade involved in positive regulation of cell growth - GOC:TermGenie - - - - - protein kinase cascade involved in stimulation of cell growth - GOC:TermGenie - - - - - protein kinase cascade involved in up regulation of cell growth - GOC:TermGenie - - - - - protein kinase cascade involved in up-regulation of cell growth - GOC:TermGenie - - - - - protein kinase cascade involved in upregulation of cell growth - GOC:TermGenie - - - - - signal transmission via intracellular cascade involved in activation of cell growth - GOC:TermGenie - - - - - signal transmission via intracellular cascade involved in positive regulation of cell growth - GOC:TermGenie - - - - - signal transmission via intracellular cascade involved in stimulation of cell growth - GOC:TermGenie - - - - - signal transmission via intracellular cascade involved in up regulation of cell growth - GOC:TermGenie - - - - - signal transmission via intracellular cascade involved in up-regulation of cell growth - GOC:TermGenie - - - - - signal transmission via intracellular cascade involved in upregulation of cell growth - GOC:TermGenie - - - - - intracellular signaling cascade involved in activation of cell growth - GOC:TermGenie - - - - - intracellular signaling cascade involved in positive regulation of cell growth - GOC:TermGenie - - - - - intracellular signaling cascade involved in stimulation of cell growth - GOC:TermGenie - - - - - intracellular signaling cascade involved in up regulation of cell growth - GOC:TermGenie - - - - - intracellular signaling cascade involved in up-regulation of cell growth - GOC:TermGenie - - - - - intracellular signaling cascade involved in upregulation of cell growth - GOC:TermGenie - - - - - intracellular signaling pathway involved in activation of cell growth - GOC:TermGenie - - - - - intracellular signaling pathway involved in positive regulation of cell growth - GOC:TermGenie - - - - - intracellular signaling pathway involved in stimulation of cell growth - GOC:TermGenie - - - - - intracellular signaling pathway involved in up regulation of cell growth - GOC:TermGenie - - - - - intracellular signaling pathway involved in up-regulation of cell growth - GOC:TermGenie - - - - - intracellular signaling pathway involved in upregulation of cell growth - GOC:TermGenie + Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + GO:jl + + + + + + + + + The chemical reactions and pathways by which individual cells transform chemical substances. + cellular metabolism + biological_process + intermediary metabolism + GO:0044237 + + cellular metabolic process + - - - signal transduction via intracellular signaling cascade involved in activation of cell growth - GOC:TermGenie + + + The chemical reactions and pathways by which individual cells transform chemical substances. + GOC:go_curators - + - signal transduction via intracellular signaling cascade involved in positive regulation of cell growth - GOC:TermGenie + intermediary metabolism + GOC:mah + + + + + + + + The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. + primary metabolism + biological_process + GO:0044238 + + primary metabolic process + - - - signal transduction via intracellular signaling cascade involved in stimulation of cell growth - GOC:TermGenie + + + The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. + GOC:go_curators + http://www.metacyc.org + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, as carried out by individual cells. + cellular polysaccharide breakdown + cellular polysaccharide catabolism + cellular polysaccharide degradation + biological_process + GO:0044247 + cellular polysaccharide catabolic process + - - - signal transduction via intracellular signaling cascade involved in up regulation of cell growth - GOC:TermGenie + + + The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, as carried out by individual cells. + GOC:jl + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + cellular breakdown + cellular catabolism + cellular degradation + biological_process + GO:0044248 + cellular catabolic process + - - - signal transduction via intracellular signaling cascade involved in up-regulation of cell growth - GOC:TermGenie + + + The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + GOC:jl + + + + + + + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + cellular anabolism + cellular biosynthesis + cellular formation + cellular synthesis + biological_process + GO:0044249 + cellular biosynthetic process + - - - signal transduction via intracellular signaling cascade involved in upregulation of cell growth - GOC:TermGenie + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:jl - + - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. - bf - 2016-09-14T10:56:47Z + + + + The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. + GO:0034960 + cellular biopolymer metabolic process + cellular macromolecule metabolism biological_process - regulation of neuropeptide-mediated retrograde trans-synaptic signaling - GO:1905432 - regulation of retrograde trans-synaptic signaling by neuropeptide + GO:0044260 + cellular macromolecule metabolic process - + - Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. - GOC:PARL - GOC:TermGenie - GOC:bf - GO_REF:0000058 - PMID:19448629 + The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. + GOC:mah - - - regulation of neuropeptide-mediated retrograde trans-synaptic signaling - GOC:bf + + + cellular biopolymer metabolic process + GOC:mtg_chebi_dec09 - + - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. - bf - 2016-09-14T10:56:55Z - down regulation of retrograde trans-synaptic signaling by neuropeptide - down-regulation of retrograde trans-synaptic signaling by neuropeptide - downregulation of retrograde trans-synaptic signaling by neuropeptide - inhibition of retrograde trans-synaptic signaling by neuropeptide + + + + The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + GO:0006092 + cellular carbohydrate metabolism + main pathways of carbohydrate metabolic process + main pathways of carbohydrate metabolism biological_process - inhibition of neuropeptide-mediated retrograde trans-synaptic signaling - negative regulation of neuropeptide-mediated retrograde trans-synaptic signaling - GO:1905433 - negative regulation of retrograde trans-synaptic signaling by neuropeptide + GO:0044262 + cellular carbohydrate metabolic process - + - Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. - GOC:PARL - GOC:TermGenie - GOC:bf - GO_REF:0000058 - PMID:19448629 - - - - - down regulation of retrograde trans-synaptic signaling by neuropeptide - GOC:TermGenie - - - - - down-regulation of retrograde trans-synaptic signaling by neuropeptide - GOC:TermGenie - - - - - downregulation of retrograde trans-synaptic signaling by neuropeptide - GOC:TermGenie - - - - - inhibition of retrograde trans-synaptic signaling by neuropeptide - GOC:TermGenie - - - - - inhibition of neuropeptide-mediated retrograde trans-synaptic signaling - GOC:bf - - - - - negative regulation of neuropeptide-mediated retrograde trans-synaptic signaling - GOC:bf + The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + GOC:jl - + - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. - bf - 2016-09-14T10:57:02Z - up regulation of retrograde trans-synaptic signaling by neuropeptide - up-regulation of retrograde trans-synaptic signaling by neuropeptide - upregulation of retrograde trans-synaptic signaling by neuropeptide - activation of retrograde trans-synaptic signaling by neuropeptide + + + + + The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells. + cellular glycan metabolic process + cellular glycan metabolism + cellular polysaccharide metabolism biological_process - positive regulation of neuropeptide-mediated retrograde trans-synaptic signaling - GO:1905434 - positive regulation of retrograde trans-synaptic signaling by neuropeptide + GO:0044264 + cellular polysaccharide metabolic process - + - Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. - GOC:PARL - GOC:TermGenie - GOC:bf - GO_REF:0000058 - PMID:19448629 - - - - - up regulation of retrograde trans-synaptic signaling by neuropeptide - GOC:TermGenie - - - - - up-regulation of retrograde trans-synaptic signaling by neuropeptide - GOC:TermGenie - - - - - upregulation of retrograde trans-synaptic signaling by neuropeptide - GOC:TermGenie - - - - - activation of retrograde trans-synaptic signaling by neuropeptide - GOC:TermGenie - - - - - positive regulation of neuropeptide-mediated retrograde trans-synaptic signaling - GOC:bf + The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells. + GOC:jl - + - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation. - rz - 2016-09-16T12:32:18Z + + + + + The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + cellular carbohydrate breakdown + cellular carbohydrate catabolism + cellular carbohydrate degradation biological_process - GO:1905453 - regulation of myeloid progenitor cell differentiation + GO:0044275 + cellular carbohydrate catabolic process - + - Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation. - GOC:TermGenie - GO_REF:0000058 - PMID:27010503 + The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. + GOC:jl - + - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation. - rz - 2016-09-16T12:32:26Z - down regulation of myeloid progenitor cell differentiation - down-regulation of myeloid progenitor cell differentiation - downregulation of myeloid progenitor cell differentiation - inhibition of myeloid progenitor cell differentiation + + + The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. + jl + 2010-01-26T12:05:20Z + small molecule metabolism biological_process - GO:1905454 - negative regulation of myeloid progenitor cell differentiation + GO:0044281 + + + + Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. + small molecule metabolic process - + - Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation. - GOC:TermGenie - GO_REF:0000058 - PMID:27010503 - - - - - down regulation of myeloid progenitor cell differentiation - GOC:TermGenie - - - - - down-regulation of myeloid progenitor cell differentiation - GOC:TermGenie - - - - - downregulation of myeloid progenitor cell differentiation - GOC:TermGenie + The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. + GOC:curators + GOC:pde + GOC:vw + + + + + + + + + The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. + jl + 2010-01-26T12:06:49Z + small molecule biosynthesis + biological_process + GO:0044283 + + Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. + small molecule biosynthetic process + - - - inhibition of myeloid progenitor cell differentiation - GOC:TermGenie + + + The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. + GOC:curators + GOC:pde + GOC:vw - + - - - - - - - - - - - - - - + + - - + + - Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation. - rz - 2016-09-16T12:32:33Z - up regulation of myeloid progenitor cell differentiation - up-regulation of myeloid progenitor cell differentiation - upregulation of myeloid progenitor cell differentiation - activation of myeloid progenitor cell differentiation - biological_process - GO:1905455 - positive regulation of myeloid progenitor cell differentiation + + + + + + + + + + + + + + + + + The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. + + jl + 2010-02-05T10:37:16Z + FBbt:00005107 + FMA:67301 + Wikipedia:Cell_body + cell soma + cellular_component + GO:0044297 + Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. + cell body - + - Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation. - GOC:TermGenie - GO_REF:0000058 - PMID:27010503 + The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. + GOC:go_curators + + + + + + + + + A biological process that directly contributes to the process of producing new individuals, involving another organism. + jl + 2012-09-19T15:56:30Z + biological_process + GO:0044703 + + multi-organism reproductive process + - - - up regulation of myeloid progenitor cell differentiation - GOC:TermGenie + + + A biological process that directly contributes to the process of producing new individuals, involving another organism. + GOC:jl + + + + + + + + + The directed movement of a protein to a specific location. + establishment of protein localisation + protein positioning + protein recruitment + biological_process + GO:0045184 + establishment of protein localization + - - - up-regulation of myeloid progenitor cell differentiation - GOC:TermGenie + + + The directed movement of a protein to a specific location. + GOC:bf - + - upregulation of myeloid progenitor cell differentiation - GOC:TermGenie - - - - - activation of myeloid progenitor cell differentiation - GOC:TermGenie + establishment of protein localisation + GOC:mah - + - + - - + + - + + + - - + + - Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. - rph - 2016-09-19T11:33:54Z - regulation of VSMC apoptotic process - regulation of vascular smooth muscle cell apoptotic process - regulation of VSMC apoptosis - regulation of vascular associated smooth muscle cell apoptosis - regulation of vascular smooth muscle cell apoptosis + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + down regulation of glycogen biosynthetic process + down-regulation of glycogen biosynthetic process + downregulation of glycogen biosynthetic process + negative regulation of glycogen anabolism + negative regulation of glycogen biosynthesis + negative regulation of glycogen formation + negative regulation of glycogen synthesis + inhibition of glycogen biosynthetic process biological_process - GO:1905459 - regulation of vascular associated smooth muscle cell apoptotic process + GO:0045719 + negative regulation of glycogen biosynthetic process - + - Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:26493107 - - - - - regulation of VSMC apoptotic process - GOC:TermGenie - - - - - regulation of vascular smooth muscle cell apoptotic process - GOC:TermGenie - - - - - regulation of VSMC apoptosis - GOC:TermGenie - - - - - regulation of vascular associated smooth muscle cell apoptosis - GOC:TermGenie - - - - - regulation of vascular smooth muscle cell apoptosis - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + GOC:go_curators - + - + - - + + - - + + + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. - rph - 2016-09-19T11:34:03Z - down regulation of VSMC apoptotic process - down regulation of vascular associated smooth muscle cell apoptotic process - down regulation of vascular smooth muscle cell apoptotic process - down-regulation of VSMC apoptotic process - down-regulation of vascular associated smooth muscle cell apoptotic process - down-regulation of vascular smooth muscle cell apoptotic process - downregulation of VSMC apoptotic process - downregulation of vascular associated smooth muscle cell apoptotic process - downregulation of vascular smooth muscle cell apoptotic process - negative regulation of VSMC apoptotic process - negative regulation of vascular smooth muscle cell apoptotic process - down regulation of VSMC apoptosis - down regulation of vascular associated smooth muscle cell apoptosis - down regulation of vascular smooth muscle cell apoptosis - down-regulation of VSMC apoptosis - down-regulation of vascular associated smooth muscle cell apoptosis - down-regulation of vascular smooth muscle cell apoptosis - downregulation of VSMC apoptosis - downregulation of vascular associated smooth muscle cell apoptosis - downregulation of vascular smooth muscle cell apoptosis - inhibition of VSMC apoptosis - inhibition of VSMC apoptotic process - inhibition of vascular associated smooth muscle cell apoptosis - inhibition of vascular associated smooth muscle cell apoptotic process - inhibition of vascular smooth muscle cell apoptosis - inhibition of vascular smooth muscle cell apoptotic process - negative regulation of VSMC apoptosis - negative regulation of vascular associated smooth muscle cell apoptosis - negative regulation of vascular smooth muscle cell apoptosis + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + positive regulation of glycogen anabolism + positive regulation of glycogen biosynthesis + positive regulation of glycogen formation + positive regulation of glycogen synthesis + up regulation of glycogen biosynthetic process + up-regulation of glycogen biosynthetic process + upregulation of glycogen biosynthetic process + activation of glycogen biosynthetic process + stimulation of glycogen biosynthetic process biological_process - GO:1905460 - negative regulation of vascular associated smooth muscle cell apoptotic process + GO:0045725 + positive regulation of glycogen biosynthetic process - + - Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:26493107 - - - - - down regulation of VSMC apoptotic process - GOC:TermGenie - - - - - down regulation of vascular associated smooth muscle cell apoptotic process - GOC:TermGenie - - - - - down regulation of vascular smooth muscle cell apoptotic process - GOC:TermGenie - - - - - down-regulation of VSMC apoptotic process - GOC:TermGenie - - - - - down-regulation of vascular associated smooth muscle cell apoptotic process - GOC:TermGenie - - - - - down-regulation of vascular smooth muscle cell apoptotic process - GOC:TermGenie - - - - - downregulation of VSMC apoptotic process - GOC:TermGenie - - - - - downregulation of vascular associated smooth muscle cell apoptotic process - GOC:TermGenie - - - - - downregulation of vascular smooth muscle cell apoptotic process - GOC:TermGenie - - - - - negative regulation of VSMC apoptotic process - GOC:TermGenie - - - - - negative regulation of vascular smooth muscle cell apoptotic process - GOC:TermGenie - - - - - down regulation of VSMC apoptosis - GOC:TermGenie - - - - - down regulation of vascular associated smooth muscle cell apoptosis - GOC:TermGenie - - - - - down regulation of vascular smooth muscle cell apoptosis - GOC:TermGenie - - - - - down-regulation of VSMC apoptosis - GOC:TermGenie - - - - - down-regulation of vascular associated smooth muscle cell apoptosis - GOC:TermGenie - - - - - down-regulation of vascular smooth muscle cell apoptosis - GOC:TermGenie - - - - - downregulation of VSMC apoptosis - GOC:TermGenie - - - - - downregulation of vascular associated smooth muscle cell apoptosis - GOC:TermGenie - - - - - downregulation of vascular smooth muscle cell apoptosis - GOC:TermGenie - - - - - inhibition of VSMC apoptosis - GOC:TermGenie - - - - - inhibition of VSMC apoptotic process - GOC:TermGenie - - - - - inhibition of vascular associated smooth muscle cell apoptosis - GOC:TermGenie - - - - - inhibition of vascular associated smooth muscle cell apoptotic process - GOC:TermGenie - - - - - inhibition of vascular smooth muscle cell apoptosis - GOC:TermGenie - - - - - inhibition of vascular smooth muscle cell apoptotic process - GOC:TermGenie - - - - - negative regulation of VSMC apoptosis - GOC:TermGenie - - - - - negative regulation of vascular associated smooth muscle cell apoptosis - GOC:TermGenie - - - - - negative regulation of vascular smooth muscle cell apoptosis - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + GOC:go_curators - + - + - - + + - - + + - - + + - Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. - rph - 2016-09-19T11:34:10Z - positive regulation of VSMC apoptotic process - positive regulation of vascular smooth muscle cell apoptotic process - up regulation of VSMC apoptotic process - up regulation of vascular associated smooth muscle cell apoptotic process - up regulation of vascular smooth muscle cell apoptotic process - up-regulation of VSMC apoptotic process - up-regulation of vascular associated smooth muscle cell apoptotic process - up-regulation of vascular smooth muscle cell apoptotic process - upregulation of VSMC apoptotic process - upregulation of vascular associated smooth muscle cell apoptotic process - upregulation of vascular smooth muscle cell apoptotic process - activation of VSMC apoptosis - activation of VSMC apoptotic process - activation of vascular associated smooth muscle cell apoptosis - activation of vascular associated smooth muscle cell apoptotic process - activation of vascular smooth muscle cell apoptosis - activation of vascular smooth muscle cell apoptotic process - positive regulation of VSMC apoptosis - positive regulation of vascular associated smooth muscle cell apoptosis - positive regulation of vascular smooth muscle cell apoptosis - up regulation of VSMC apoptosis - up regulation of vascular associated smooth muscle cell apoptosis - up regulation of vascular smooth muscle cell apoptosis - up-regulation of VSMC apoptosis - up-regulation of vascular associated smooth muscle cell apoptosis - up-regulation of vascular smooth muscle cell apoptosis - upregulation of VSMC apoptosis - upregulation of vascular associated smooth muscle cell apoptosis - upregulation of vascular smooth muscle cell apoptosis + Any process that modulates the frequency, rate or extent of angiogenesis. biological_process - GO:1905461 - positive regulation of vascular associated smooth muscle cell apoptotic process + GO:0045765 + regulation of angiogenesis - + - Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:26493107 - - - - - positive regulation of VSMC apoptotic process - GOC:TermGenie - - - - - positive regulation of vascular smooth muscle cell apoptotic process - GOC:TermGenie - - - - - up regulation of VSMC apoptotic process - GOC:TermGenie - - - - - up regulation of vascular associated smooth muscle cell apoptotic process - GOC:TermGenie - - - - - up regulation of vascular smooth muscle cell apoptotic process - GOC:TermGenie - - - - - up-regulation of VSMC apoptotic process - GOC:TermGenie - - - - - up-regulation of vascular associated smooth muscle cell apoptotic process - GOC:TermGenie - - - - - up-regulation of vascular smooth muscle cell apoptotic process - GOC:TermGenie - - - - - upregulation of VSMC apoptotic process - GOC:TermGenie - - - - - upregulation of vascular associated smooth muscle cell apoptotic process - GOC:TermGenie - - - - - upregulation of vascular smooth muscle cell apoptotic process - GOC:TermGenie - - - - - activation of VSMC apoptosis - GOC:TermGenie - - - - - activation of VSMC apoptotic process - GOC:TermGenie - - - - - activation of vascular associated smooth muscle cell apoptosis - GOC:TermGenie - - - - - activation of vascular associated smooth muscle cell apoptotic process - GOC:TermGenie - - - - - activation of vascular smooth muscle cell apoptosis - GOC:TermGenie - - - - - activation of vascular smooth muscle cell apoptotic process - GOC:TermGenie - - - - - positive regulation of VSMC apoptosis - GOC:TermGenie - - - - - positive regulation of vascular associated smooth muscle cell apoptosis - GOC:TermGenie - - - - - positive regulation of vascular smooth muscle cell apoptosis - GOC:TermGenie - - - - - up regulation of VSMC apoptosis - GOC:TermGenie - - - - - up regulation of vascular associated smooth muscle cell apoptosis - GOC:TermGenie - - - - - up regulation of vascular smooth muscle cell apoptosis - GOC:TermGenie - - - - - up-regulation of VSMC apoptosis - GOC:TermGenie - - - - - up-regulation of vascular associated smooth muscle cell apoptosis - GOC:TermGenie - - - - - up-regulation of vascular smooth muscle cell apoptosis - GOC:TermGenie - - - - - upregulation of VSMC apoptosis - GOC:TermGenie - - - - - upregulation of vascular associated smooth muscle cell apoptosis - GOC:TermGenie - - - - - upregulation of vascular smooth muscle cell apoptosis - GOC:TermGenie + Any process that modulates the frequency, rate or extent of angiogenesis. + GOC:go_curators - + - + - - + + - + + - - + + - Any process that modulates the frequency, rate or extent of protein localization to membrane. - bc - 2016-09-21T16:20:03Z - regulation of protein localisation in membrane - regulation of protein localization in membrane + Any process that activates or increases angiogenesis. + up regulation of angiogenesis + up-regulation of angiogenesis + upregulation of angiogenesis + activation of angiogenesis + stimulation of angiogenesis biological_process - GO:1905475 - regulation of protein localization to membrane + GO:0045766 + positive regulation of angiogenesis - + - Any process that modulates the frequency, rate or extent of protein localization to membrane. - GOC:PARL - GOC:TermGenie - GOC:bc - GO_REF:0000058 - PMID:26911690 - - - - - regulation of protein localisation in membrane - GOC:TermGenie - - - - - regulation of protein localization in membrane - GOC:TermGenie + Any process that activates or increases angiogenesis. + GOC:go_curators - + - + - - + + - - + + - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane. - bc - 2016-09-21T16:20:10Z - down regulation of protein localisation in membrane - down regulation of protein localization in membrane - down regulation of protein localization to membrane - down-regulation of protein localisation in membrane - down-regulation of protein localization in membrane - down-regulation of protein localization to membrane - downregulation of protein localisation in membrane - downregulation of protein localization in membrane - downregulation of protein localization to membrane - negative regulation of protein localisation in membrane - negative regulation of protein localization in membrane - inhibition of protein localisation in membrane - inhibition of protein localization in membrane - inhibition of protein localization to membrane + + + + + Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + positive regulation of bone biosynthesis + positive regulation of bone formation + up regulation of ossification + up-regulation of ossification + upregulation of ossification + activation of ossification + stimulation of ossification biological_process - GO:1905476 - negative regulation of protein localization to membrane + GO:0045778 + positive regulation of ossification - + - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane. - GOC:PARL - GOC:TermGenie - GOC:bc - GO_REF:0000058 - PMID:26911690 - - - - - down regulation of protein localisation in membrane - GOC:TermGenie - - - - - down regulation of protein localization in membrane - GOC:TermGenie - - - - - down regulation of protein localization to membrane - GOC:TermGenie - - - - - down-regulation of protein localisation in membrane - GOC:TermGenie - - - - - down-regulation of protein localization in membrane - GOC:TermGenie - - - - - down-regulation of protein localization to membrane - GOC:TermGenie - - - - - downregulation of protein localisation in membrane - GOC:TermGenie - - - - - downregulation of protein localization in membrane - GOC:TermGenie - - - - - downregulation of protein localization to membrane - GOC:TermGenie - - - - - negative regulation of protein localisation in membrane - GOC:TermGenie - - - - - negative regulation of protein localization in membrane - GOC:TermGenie - - - - - inhibition of protein localisation in membrane - GOC:TermGenie - - - - - inhibition of protein localization in membrane - GOC:TermGenie - - - - - inhibition of protein localization to membrane - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + GOC:go_curators - + - + - - + + - - + + + - - - - - Any process that activates or increases the frequency, rate or extent of protein localization to membrane. - bc - 2016-09-21T16:20:18Z - positive regulation of protein localisation in membrane - positive regulation of protein localization in membrane - up regulation of protein localisation in membrane - up regulation of protein localization in membrane - up regulation of protein localization to membrane - up-regulation of protein localisation in membrane - up-regulation of protein localization in membrane - up-regulation of protein localization to membrane - upregulation of protein localisation in membrane - upregulation of protein localization in membrane - upregulation of protein localization to membrane - activation of protein localisation in membrane - activation of protein localization in membrane - activation of protein localization to membrane + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + down regulation of glycogen catabolic process + down-regulation of glycogen catabolic process + downregulation of glycogen catabolic process + negative regulation of glycogen breakdown + negative regulation of glycogen catabolism + negative regulation of glycogen degradation + negative regulation of glycogenolysis + inhibition of glycogen catabolic process biological_process - GO:1905477 - positive regulation of protein localization to membrane + GO:0045818 + negative regulation of glycogen catabolic process - + - Any process that activates or increases the frequency, rate or extent of protein localization to membrane. - GOC:PARL - GOC:TermGenie - GOC:bc - GO_REF:0000058 - PMID:26911690 - - - - - positive regulation of protein localisation in membrane - GOC:TermGenie - - - - - positive regulation of protein localization in membrane - GOC:TermGenie - - - - - up regulation of protein localisation in membrane - GOC:TermGenie - - - - - up regulation of protein localization in membrane - GOC:TermGenie - - - - - up regulation of protein localization to membrane - GOC:TermGenie - - - - - up-regulation of protein localisation in membrane - GOC:TermGenie - - - - - up-regulation of protein localization in membrane - GOC:TermGenie - - - - - up-regulation of protein localization to membrane - GOC:TermGenie - - - - - upregulation of protein localisation in membrane - GOC:TermGenie - - - - - upregulation of protein localization in membrane - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + GOC:go_curators - + - upregulation of protein localization to membrane - GOC:TermGenie - - - - - activation of protein localisation in membrane - GOC:TermGenie - - - - - activation of protein localization in membrane - GOC:TermGenie - - - - - activation of protein localization to membrane - GOC:TermGenie + negative regulation of glycogenolysis + GOC:sl - + - + - + - - - + + + - + - Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve. - hbye - 2016-09-23T14:11:52Z - up regulation of branching morphogenesis of a nerve - up-regulation of branching morphogenesis of a nerve - upregulation of branching morphogenesis of a nerve - activation of branching morphogenesis of a nerve + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + positive regulation of glycogen breakdown + positive regulation of glycogen catabolism + positive regulation of glycogen degradation + positive regulation of glycogenolysis + up regulation of glycogen catabolic process + up-regulation of glycogen catabolic process + upregulation of glycogen catabolic process + activation of glycogen catabolic process + stimulation of glycogen catabolic process biological_process - GO:1905492 - positive regulation of branching morphogenesis of a nerve + GO:0045819 + positive regulation of glycogen catabolic process - + - Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve. - GOC:TermGenie - GO_REF:0000058 - PMID:16516839 - - - - - up regulation of branching morphogenesis of a nerve - GOC:TermGenie - - - - - up-regulation of branching morphogenesis of a nerve - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + GOC:go_curators - + - upregulation of branching morphogenesis of a nerve - GOC:TermGenie - - - - - activation of branching morphogenesis of a nerve - GOC:TermGenie + positive regulation of glycogenolysis + GOC:sl - + - + - - + + - - + + - - + + - Any process that activates or increases the frequency, rate or extent of fertilization. - pr - 2016-09-30T14:32:32Z - positive regulation of syngamy - up regulation of fertilization - up regulation of syngamy - up-regulation of fertilization - up-regulation of syngamy - upregulation of fertilization - upregulation of syngamy - activation of fertilization - activation of syngamy + Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. + down regulation of heart contraction + down-regulation of heart contraction + downregulation of heart contraction + inhibition of heart contraction biological_process - GO:1905516 - positive regulation of fertilization + negative regulation of cardiac contraction + GO:0045822 + negative regulation of heart contraction - + - Any process that activates or increases the frequency, rate or extent of fertilization. - GOC:TermGenie - GOC:hbye - GO_REF:0000058 - PMID:27564576 - - - - - positive regulation of syngamy - GOC:TermGenie - - - - - up regulation of fertilization - GOC:TermGenie - - - - - up regulation of syngamy - GOC:TermGenie - - - - - up-regulation of fertilization - GOC:TermGenie - - - - - up-regulation of syngamy - GOC:TermGenie - - - - - upregulation of fertilization - GOC:TermGenie - - - - - upregulation of syngamy - GOC:TermGenie - - - - - activation of fertilization - GOC:TermGenie - - - - - activation of syngamy - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. + GOC:go_curators - + - + - - + + - - - + + - - + + - Any process that modulates the frequency, rate or extent of blood vessel branching. - nc - 2016-10-12T14:19:33Z - regulation of branching involved in blood vessel morphogenesis + Any process that activates or increases the frequency, rate or extent of heart contraction. + positive regulation of cardiac contraction + up regulation of heart contraction + up-regulation of heart contraction + upregulation of heart contraction + activation of heart contraction + stimulation of heart contraction biological_process - GO:1905553 - regulation of blood vessel branching + GO:0045823 + positive regulation of heart contraction - + - Any process that modulates the frequency, rate or extent of blood vessel branching. - GOC:BHF - GOC:BHF_telomere - GOC:TermGenie - GOC:nc - GO_REF:0000058 - PMID:23201774 - - - - - regulation of branching involved in blood vessel morphogenesis - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of heart contraction. + GOC:go_curators - + - + - + - - - + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching. - nc - 2016-10-12T14:19:41Z - down regulation of branching involved in blood vessel morphogenesis - down regulation of patterning of blood vessels - down-regulation of branching involved in blood vessel morphogenesis - down-regulation of patterning of blood vessels - downregulation of branching involved in blood vessel morphogenesis - downregulation of patterning of blood vessels - negative regulation of branching involved in blood vessel morphogenesis - inhibition of branching involved in blood vessel morphogenesis - inhibition of patterning of blood vessels + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. + down regulation of lipid metabolic process + down-regulation of lipid metabolic process + downregulation of lipid metabolic process + negative regulation of lipid metabolism + inhibition of lipid metabolic process biological_process - GO:1905554 - negative regulation of vessel branching + GO:0045833 + negative regulation of lipid metabolic process - + - Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching. - GOC:BHF - GOC:BHF_telomere - GOC:TermGenie - GOC:nc - GO_REF:0000058 - PMID:23201774 - - - - - down regulation of branching involved in blood vessel morphogenesis - GOC:TermGenie - - - - - down regulation of patterning of blood vessels - GOC:TermGenie - - - - - down-regulation of branching involved in blood vessel morphogenesis - GOC:TermGenie - - - - - down-regulation of patterning of blood vessels - GOC:TermGenie - - - - - downregulation of branching involved in blood vessel morphogenesis - GOC:TermGenie - - - - - downregulation of patterning of blood vessels - GOC:TermGenie - - - - - negative regulation of branching involved in blood vessel morphogenesis - GOC:TermGenie - - - - - inhibition of branching involved in blood vessel morphogenesis - GOC:TermGenie - - - - - inhibition of patterning of blood vessels - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. + GOC:go_curators - + - + - + - - - + + - + - Any process that activates or increases the frequency, rate or extent of blood vessel branching. - nc - 2016-10-12T14:19:49Z - positive regulation of branching involved in blood vessel morphogenesis - up regulation of branching involved in blood vessel morphogenesis - up regulation of patterning of blood vessels - up-regulation of branching involved in blood vessel morphogenesis - up-regulation of patterning of blood vessels - upregulation of branching involved in blood vessel morphogenesis - upregulation of patterning of blood vessels - activation of branching involved in blood vessel morphogenesis - activation of patterning of blood vessels + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. + positive regulation of lipid metabolism + up regulation of lipid metabolic process + up-regulation of lipid metabolic process + upregulation of lipid metabolic process + activation of lipid metabolic process + stimulation of lipid metabolic process biological_process - GO:1905555 - positive regulation of blood vessel branching + GO:0045834 + positive regulation of lipid metabolic process - - - Any process that activates or increases the frequency, rate or extent of blood vessel branching. - GOC:BHF - GOC:BHF_telomere - GOC:TermGenie - GOC:nc - GO_REF:0000058 - PMID:23201774 - - - - - positive regulation of branching involved in blood vessel morphogenesis - GOC:TermGenie - - - - - up regulation of branching involved in blood vessel morphogenesis - GOC:TermGenie - - - - - up regulation of patterning of blood vessels - GOC:TermGenie - - - - - up-regulation of branching involved in blood vessel morphogenesis - GOC:TermGenie - - - - - up-regulation of patterning of blood vessels - GOC:TermGenie - - - - - upregulation of branching involved in blood vessel morphogenesis - GOC:TermGenie - - - - - upregulation of patterning of blood vessels - GOC:TermGenie - - - - - activation of branching involved in blood vessel morphogenesis - GOC:TermGenie - - - - - activation of patterning of blood vessels - GOC:TermGenie + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. + GOC:go_curators - + - + - - + + - - + + - - + + - Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly. - hbye - 2016-10-14T13:14:57Z - regulation of mitotic nuclear envelope breakdown - regulation of mitotic nuclear envelope catabolism - regulation of mitotic nuclear envelope degradation + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. + down regulation of carbohydrate metabolic process + down-regulation of carbohydrate metabolic process + downregulation of carbohydrate metabolic process + negative regulation of carbohydrate metabolism + inhibition of carbohydrate metabolic process biological_process - GO:1905557 - regulation of mitotic nuclear envelope disassembly + GO:0045912 + negative regulation of carbohydrate metabolic process - + - Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly. - GOC:TermGenie - GO_REF:0000058 - PMID:18765790 - - - - - regulation of mitotic nuclear envelope breakdown - GOC:TermGenie - - - - - regulation of mitotic nuclear envelope catabolism - GOC:TermGenie - - - - - regulation of mitotic nuclear envelope degradation - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. + GOC:go_curators - + - + - - + + - - - + + - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly. - hbye - 2016-10-14T13:15:08Z - down regulation of mitotic nuclear envelope breakdown - down regulation of mitotic nuclear envelope catabolism - down regulation of mitotic nuclear envelope degradation - down regulation of mitotic nuclear envelope disassembly - down-regulation of mitotic nuclear envelope breakdown - down-regulation of mitotic nuclear envelope catabolism - down-regulation of mitotic nuclear envelope degradation - down-regulation of mitotic nuclear envelope disassembly - downregulation of mitotic nuclear envelope breakdown - downregulation of mitotic nuclear envelope catabolism - downregulation of mitotic nuclear envelope degradation - downregulation of mitotic nuclear envelope disassembly - negative regulation of mitotic nuclear envelope breakdown - negative regulation of mitotic nuclear envelope catabolism - negative regulation of mitotic nuclear envelope degradation - inhibition of mitotic nuclear envelope breakdown - inhibition of mitotic nuclear envelope catabolism - inhibition of mitotic nuclear envelope degradation - inhibition of mitotic nuclear envelope disassembly + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. + positive regulation of carbohydrate metabolism + up regulation of carbohydrate metabolic process + up-regulation of carbohydrate metabolic process + upregulation of carbohydrate metabolic process + activation of carbohydrate metabolic process + stimulation of carbohydrate metabolic process biological_process - GO:1905558 - negative regulation of mitotic nuclear envelope disassembly + GO:0045913 + positive regulation of carbohydrate metabolic process - + - Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly. - GOC:TermGenie - GO_REF:0000058 - PMID:18765790 - - - - - down regulation of mitotic nuclear envelope breakdown - GOC:TermGenie - - - - - down regulation of mitotic nuclear envelope catabolism - GOC:TermGenie - - - - - down regulation of mitotic nuclear envelope degradation - GOC:TermGenie - - - - - down regulation of mitotic nuclear envelope disassembly - GOC:TermGenie - - - - - down-regulation of mitotic nuclear envelope breakdown - GOC:TermGenie - - - - - down-regulation of mitotic nuclear envelope catabolism - GOC:TermGenie - - - - - down-regulation of mitotic nuclear envelope degradation - GOC:TermGenie - - - - - down-regulation of mitotic nuclear envelope disassembly - GOC:TermGenie - - - - - downregulation of mitotic nuclear envelope breakdown - GOC:TermGenie - - - - - downregulation of mitotic nuclear envelope catabolism - GOC:TermGenie - - - - - downregulation of mitotic nuclear envelope degradation - GOC:TermGenie - - - - - downregulation of mitotic nuclear envelope disassembly - GOC:TermGenie - - - - - negative regulation of mitotic nuclear envelope breakdown - GOC:TermGenie - - - - - negative regulation of mitotic nuclear envelope catabolism - GOC:TermGenie - - - - - negative regulation of mitotic nuclear envelope degradation - GOC:TermGenie - - - - - inhibition of mitotic nuclear envelope breakdown - GOC:TermGenie - - - - - inhibition of mitotic nuclear envelope catabolism - GOC:TermGenie - - - - - inhibition of mitotic nuclear envelope degradation - GOC:TermGenie - - - - - inhibition of mitotic nuclear envelope disassembly - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. + GOC:go_curators - + - + - - + + - - - + + - - - - - Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly. - hbye - 2016-10-14T13:15:17Z - positive regulation of mitotic nuclear envelope breakdown - positive regulation of mitotic nuclear envelope catabolism - positive regulation of mitotic nuclear envelope degradation - up regulation of mitotic nuclear envelope breakdown - up regulation of mitotic nuclear envelope catabolism - up regulation of mitotic nuclear envelope degradation - up regulation of mitotic nuclear envelope disassembly - up-regulation of mitotic nuclear envelope breakdown - up-regulation of mitotic nuclear envelope catabolism - up-regulation of mitotic nuclear envelope degradation - up-regulation of mitotic nuclear envelope disassembly - upregulation of mitotic nuclear envelope breakdown - upregulation of mitotic nuclear envelope catabolism - upregulation of mitotic nuclear envelope degradation - upregulation of mitotic nuclear envelope disassembly - activation of mitotic nuclear envelope breakdown - activation of mitotic nuclear envelope catabolism - activation of mitotic nuclear envelope degradation - activation of mitotic nuclear envelope disassembly + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. + down regulation of muscle contraction + down-regulation of muscle contraction + downregulation of muscle contraction + inhibition of muscle contraction biological_process - GO:1905559 - positive regulation of mitotic nuclear envelope disassembly + GO:0045932 + negative regulation of muscle contraction - + - Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly. - GOC:TermGenie - GO_REF:0000058 - PMID:18765790 - - - - - positive regulation of mitotic nuclear envelope breakdown - GOC:TermGenie - - - - - positive regulation of mitotic nuclear envelope catabolism - GOC:TermGenie - - - - - positive regulation of mitotic nuclear envelope degradation - GOC:TermGenie - - - - - up regulation of mitotic nuclear envelope breakdown - GOC:TermGenie - - - - - up regulation of mitotic nuclear envelope catabolism - GOC:TermGenie - - - - - up regulation of mitotic nuclear envelope degradation - GOC:TermGenie - - - - - up regulation of mitotic nuclear envelope disassembly - GOC:TermGenie - - - - - up-regulation of mitotic nuclear envelope breakdown - GOC:TermGenie - - - - - up-regulation of mitotic nuclear envelope catabolism - GOC:TermGenie - - - - - up-regulation of mitotic nuclear envelope degradation - GOC:TermGenie - - - - - up-regulation of mitotic nuclear envelope disassembly - GOC:TermGenie - - - - - upregulation of mitotic nuclear envelope breakdown - GOC:TermGenie - - - - - upregulation of mitotic nuclear envelope catabolism - GOC:TermGenie - - - - - upregulation of mitotic nuclear envelope degradation - GOC:TermGenie - - - - - upregulation of mitotic nuclear envelope disassembly - GOC:TermGenie - - - - - activation of mitotic nuclear envelope breakdown - GOC:TermGenie - - - - - activation of mitotic nuclear envelope catabolism - GOC:TermGenie - - - - - activation of mitotic nuclear envelope degradation - GOC:TermGenie - - - - - activation of mitotic nuclear envelope disassembly - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. + GOC:go_curators - + - + - - + + - + + - - + + - Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation. - nc - 2016-10-17T09:24:17Z + Any process that activates or increases the frequency, rate or extent of muscle contraction. + up regulation of muscle contraction + up-regulation of muscle contraction + upregulation of muscle contraction + activation of muscle contraction + stimulation of muscle contraction biological_process - GO:1905562 - regulation of vascular endothelial cell proliferation + GO:0045933 + positive regulation of muscle contraction - + - Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation. - GOC:BHF - GOC:BHF_telomere - GOC:TermGenie - GOC:nc - GO_REF:0000058 - PMID:23201774 + Any process that activates or increases the frequency, rate or extent of muscle contraction. + GOC:go_curators - + - + - + - - + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation. - nc - 2016-10-17T09:24:26Z - down regulation of vascular endothelial cell proliferation - down-regulation of vascular endothelial cell proliferation - downregulation of vascular endothelial cell proliferation - inhibition of vascular endothelial cell proliferation + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. + down regulation of steroid metabolic process + down-regulation of steroid metabolic process + downregulation of steroid metabolic process + negative regulation of steroid metabolism + inhibition of steroid metabolic process biological_process - GO:1905563 - negative regulation of vascular endothelial cell proliferation + GO:0045939 + negative regulation of steroid metabolic process - + - Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation. - GOC:BHF - GOC:BHF_telomere - GOC:TermGenie - GOC:nc - GO_REF:0000058 - PMID:23201774 - - - - - down regulation of vascular endothelial cell proliferation - GOC:TermGenie - - - - - down-regulation of vascular endothelial cell proliferation - GOC:TermGenie - - - - - downregulation of vascular endothelial cell proliferation - GOC:TermGenie - - - - - inhibition of vascular endothelial cell proliferation - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. + GOC:go_curators - + - + - + - - + + - + - Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation. - nc - 2016-10-17T09:24:35Z - up regulation of vascular endothelial cell proliferation - up-regulation of vascular endothelial cell proliferation - upregulation of vascular endothelial cell proliferation - activation of vascular endothelial cell proliferation + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. + positive regulation of steroid metabolism + up regulation of steroid metabolic process + up-regulation of steroid metabolic process + upregulation of steroid metabolic process + activation of steroid metabolic process + stimulation of steroid metabolic process biological_process - GO:1905564 - positive regulation of vascular endothelial cell proliferation + GO:0045940 + positive regulation of steroid metabolic process - + - Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation. - GOC:BHF - GOC:BHF_telomere - GOC:TermGenie - GOC:nc - GO_REF:0000058 - PMID:23201774 - - - - - up regulation of vascular endothelial cell proliferation - GOC:TermGenie - - - - - up-regulation of vascular endothelial cell proliferation - GOC:TermGenie - - - - - upregulation of vascular endothelial cell proliferation - GOC:TermGenie - - - - - activation of vascular endothelial cell proliferation - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. + GOC:go_curators - + - + - - + + - - - - - - - - + + - - + + - Any process that modulates the frequency, rate or extent of presynapse assembly. - bc - 2016-10-27T16:08:13Z - regulation of presynapse biogenesis - regulation of presynaptic terminal assembly + Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. + down regulation of smooth muscle contraction + down-regulation of smooth muscle contraction + downregulation of smooth muscle contraction + inhibition of smooth muscle contraction biological_process - GO:1905606 - - regulation of presynapse assembly + smooth muscle relaxation + GO:0045986 + negative regulation of smooth muscle contraction - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that modulates the frequency, rate or extent of presynapse assembly. - GOC:PARL - GOC:TermGenie - GOC:bc - GO_REF:0000058 - PMID:25533483 - - - - - regulation of presynapse biogenesis - GOC:TermGenie - - - - - regulation of presynaptic terminal assembly - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. + GOC:go_curators - + - + - - + + - - + + - - + + - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly. - bc - 2016-10-27T16:08:20Z - down regulation of presynapse assembly - down regulation of presynapse biogenesis - down regulation of presynaptic terminal assembly - down-regulation of presynapse assembly - down-regulation of presynapse biogenesis - down-regulation of presynaptic terminal assembly - downregulation of presynapse assembly - downregulation of presynapse biogenesis - downregulation of presynaptic terminal assembly - negative regulation of presynapse biogenesis - negative regulation of presynaptic terminal assembly - inhibition of presynapse assembly - inhibition of presynapse biogenesis - inhibition of presynaptic terminal assembly + Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. + up regulation of smooth muscle contraction + up-regulation of smooth muscle contraction + upregulation of smooth muscle contraction + activation of smooth muscle contraction + stimulation of smooth muscle contraction biological_process - GO:1905607 - negative regulation of presynapse assembly + GO:0045987 + positive regulation of smooth muscle contraction - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly. - GOC:PARL - GOC:TermGenie - GOC:bc - GO_REF:0000058 - PMID:25533483 - - - - - down regulation of presynapse assembly - GOC:TermGenie - - - - - down regulation of presynapse biogenesis - GOC:TermGenie - - - - - down regulation of presynaptic terminal assembly - GOC:TermGenie - - - - - down-regulation of presynapse assembly - GOC:TermGenie - - - - - down-regulation of presynapse biogenesis - GOC:TermGenie - - - - - down-regulation of presynaptic terminal assembly - GOC:TermGenie - - - - - downregulation of presynapse assembly - GOC:TermGenie - - - - - downregulation of presynapse biogenesis - GOC:TermGenie - - - - - downregulation of presynaptic terminal assembly - GOC:TermGenie - - - - - negative regulation of presynapse biogenesis - GOC:TermGenie - - - - - negative regulation of presynaptic terminal assembly - GOC:TermGenie - - - - - inhibition of presynapse assembly - GOC:TermGenie - - - - - inhibition of presynapse biogenesis - GOC:TermGenie - - - - - inhibition of presynaptic terminal assembly - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. + GOC:go_curators - + - + - - + + - - + + + - - - - - Any process that activates or increases the frequency, rate or extent of presynapse assembly. - bc - 2016-10-27T16:08:28Z - positive regulation of presynapse biogenesis - positive regulation of presynaptic terminal assembly - up regulation of presynapse assembly - up regulation of presynapse biogenesis - up regulation of presynaptic terminal assembly - up-regulation of presynapse assembly - up-regulation of presynapse biogenesis - up-regulation of presynaptic terminal assembly - upregulation of presynapse assembly - upregulation of presynapse biogenesis - upregulation of presynaptic terminal assembly - activation of presynapse assembly - activation of presynapse biogenesis - activation of presynaptic terminal assembly + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. + down regulation of embryonic development + down-regulation of embryonic development + downregulation of embryonic development + inhibition of embryonic development biological_process - GO:1905608 - positive regulation of presynapse assembly + GO:0045992 + negative regulation of embryonic development - + - Any process that activates or increases the frequency, rate or extent of presynapse assembly. - GOC:PARL - GOC:TermGenie - GOC:bc - GO_REF:0000058 - PMID:25533483 - - - - - positive regulation of presynapse biogenesis - GOC:TermGenie - - - - - positive regulation of presynaptic terminal assembly - GOC:TermGenie - - - - - up regulation of presynapse assembly - GOC:TermGenie - - - - - up regulation of presynapse biogenesis - GOC:TermGenie - - - - - up regulation of presynaptic terminal assembly - GOC:TermGenie - - - - - up-regulation of presynapse assembly - GOC:TermGenie - - - - - up-regulation of presynapse biogenesis - GOC:TermGenie - - - - - up-regulation of presynaptic terminal assembly - GOC:TermGenie - - - - - upregulation of presynapse assembly - GOC:TermGenie - - - - - upregulation of presynapse biogenesis - GOC:TermGenie - - - - - upregulation of presynaptic terminal assembly - GOC:TermGenie - - - - - activation of presynapse assembly - GOC:TermGenie - - - - - activation of presynapse biogenesis - GOC:TermGenie - - - - - activation of presynaptic terminal assembly - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. + GOC:go_curators - + - + - + - - - + - + - Any process that modulates the frequency, rate or extent of serotonin biosynthetic process. - pad - 2016-10-31T14:26:20Z - regulation of serotonin anabolism - regulation of serotonin biosynthesis - regulation of serotonin formation - regulation of serotonin synthesis + Any process that modulates the frequency, rate or extent of embryonic development. biological_process - GO:1905627 - regulation of serotonin biosynthetic process + GO:0045995 + regulation of embryonic development - + - Any process that modulates the frequency, rate or extent of serotonin biosynthetic process. - GOC:PARL - GOC:TermGenie - GOC:pad - GO_REF:0000058 - PMID:25642596 - - - - - regulation of serotonin anabolism - GOC:TermGenie - - - - - regulation of serotonin biosynthesis - GOC:TermGenie - - - - - regulation of serotonin formation - GOC:TermGenie + Any process that modulates the frequency, rate or extent of embryonic development. + GOC:go_curators + + + + + + + + + The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. + carboxylic acid anabolism + carboxylic acid biosynthesis + carboxylic acid formation + carboxylic acid synthesis + biological_process + GO:0046394 + carboxylic acid biosynthetic process + - - - regulation of serotonin synthesis - GOC:TermGenie + + + The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. + ISBN:0198506732 - + - + - + - - - - + + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process. - pad - 2016-10-31T14:26:28Z - down regulation of serotonin anabolism - down regulation of serotonin biosynthesis - down regulation of serotonin biosynthetic process - down regulation of serotonin formation - down regulation of serotonin synthesis - down-regulation of serotonin anabolism - down-regulation of serotonin biosynthesis - down-regulation of serotonin biosynthetic process - down-regulation of serotonin formation - down-regulation of serotonin synthesis - downregulation of serotonin anabolism - downregulation of serotonin biosynthesis - downregulation of serotonin biosynthetic process - downregulation of serotonin formation - downregulation of serotonin synthesis - negative regulation of serotonin anabolism - negative regulation of serotonin biosynthesis - negative regulation of serotonin formation - negative regulation of serotonin synthesis - inhibition of serotonin anabolism - inhibition of serotonin biosynthesis - inhibition of serotonin biosynthetic process - inhibition of serotonin formation - inhibition of serotonin synthesis + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. + down regulation of insulin secretion + down-regulation of insulin secretion + downregulation of insulin secretion + inhibition of insulin secretion biological_process - GO:1905628 - negative regulation of serotonin biosynthetic process + GO:0046676 + negative regulation of insulin secretion - + - Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process. - GOC:PARL - GOC:TermGenie - GOC:pad - GO_REF:0000058 - PMID:25642596 - - - - - down regulation of serotonin anabolism - GOC:TermGenie - - - - - down regulation of serotonin biosynthesis - GOC:TermGenie - - - - - down regulation of serotonin biosynthetic process - GOC:TermGenie - - - - - down regulation of serotonin formation - GOC:TermGenie - - - - - down regulation of serotonin synthesis - GOC:TermGenie - - - - - down-regulation of serotonin anabolism - GOC:TermGenie - - - - - down-regulation of serotonin biosynthesis - GOC:TermGenie - - - - - down-regulation of serotonin biosynthetic process - GOC:TermGenie - - - - - down-regulation of serotonin formation - GOC:TermGenie - - - - - down-regulation of serotonin synthesis - GOC:TermGenie - - - - - downregulation of serotonin anabolism - GOC:TermGenie - - - - - downregulation of serotonin biosynthesis - GOC:TermGenie - - - - - downregulation of serotonin biosynthetic process - GOC:TermGenie - - - - - downregulation of serotonin formation - GOC:TermGenie - - - - - downregulation of serotonin synthesis - GOC:TermGenie - - - - - negative regulation of serotonin anabolism - GOC:TermGenie - - - - - negative regulation of serotonin biosynthesis - GOC:TermGenie - - - - - negative regulation of serotonin formation - GOC:TermGenie - - - - - negative regulation of serotonin synthesis - GOC:TermGenie - - - - - inhibition of serotonin anabolism - GOC:TermGenie - - - - - inhibition of serotonin biosynthesis - GOC:TermGenie - - - - - inhibition of serotonin biosynthetic process - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. + GOC:ai + + + + + + + + The controlled release of acid by a cell or a tissue. + biological_process + GO:0046717 + acid secretion + - - - inhibition of serotonin formation - GOC:TermGenie + + + The controlled release of acid by a cell or a tissue. + GOC:ai + + + + + + + + + The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. + biological_process + GO:0046879 + hormone secretion + - - - inhibition of serotonin synthesis - GOC:TermGenie + + + The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. + ISBN:0198506732 - + - + - - + + - - - - + + + + - - + + - Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process. - pad - 2016-10-31T14:26:36Z - positive regulation of serotonin anabolism - positive regulation of serotonin biosynthesis - positive regulation of serotonin formation - positive regulation of serotonin synthesis - up regulation of serotonin anabolism - up regulation of serotonin biosynthesis - up regulation of serotonin biosynthetic process - up regulation of serotonin formation - up regulation of serotonin synthesis - up-regulation of serotonin anabolism - up-regulation of serotonin biosynthesis - up-regulation of serotonin biosynthetic process - up-regulation of serotonin formation - up-regulation of serotonin synthesis - upregulation of serotonin anabolism - upregulation of serotonin biosynthesis - upregulation of serotonin biosynthetic process - upregulation of serotonin formation - upregulation of serotonin synthesis - activation of serotonin anabolism - activation of serotonin biosynthesis - activation of serotonin biosynthetic process - activation of serotonin formation - activation of serotonin synthesis + Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. biological_process - GO:1905629 - positive regulation of serotonin biosynthetic process + GO:0046883 + regulation of hormone secretion - + - Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process. - GOC:PARL - GOC:TermGenie - GOC:pad - GO_REF:0000058 - PMID:25642596 - - - - - positive regulation of serotonin anabolism - GOC:TermGenie - - - - - positive regulation of serotonin biosynthesis - GOC:TermGenie - - - - - positive regulation of serotonin formation - GOC:TermGenie - - - - - positive regulation of serotonin synthesis - GOC:TermGenie - - - - - up regulation of serotonin anabolism - GOC:TermGenie - - - - - up regulation of serotonin biosynthesis - GOC:TermGenie - - - - - up regulation of serotonin biosynthetic process - GOC:TermGenie - - - - - up regulation of serotonin formation - GOC:TermGenie - - - - - up regulation of serotonin synthesis - GOC:TermGenie - - - - - up-regulation of serotonin anabolism - GOC:TermGenie - - - - - up-regulation of serotonin biosynthesis - GOC:TermGenie - - - - - up-regulation of serotonin biosynthetic process - GOC:TermGenie - - - - - up-regulation of serotonin formation - GOC:TermGenie - - - - - up-regulation of serotonin synthesis - GOC:TermGenie - - - - - upregulation of serotonin anabolism - GOC:TermGenie - - - - - upregulation of serotonin biosynthesis - GOC:TermGenie - - - - - upregulation of serotonin biosynthetic process - GOC:TermGenie - - - - - upregulation of serotonin formation - GOC:TermGenie - - - - - upregulation of serotonin synthesis - GOC:TermGenie - - - - - activation of serotonin anabolism - GOC:TermGenie - - - - - activation of serotonin biosynthesis - GOC:TermGenie - - - - - activation of serotonin biosynthetic process - GOC:TermGenie - - - - - activation of serotonin formation - GOC:TermGenie - - - - - activation of serotonin synthesis - GOC:TermGenie + Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. + GOC:ai - + - + - - + + - + + + + - - + + - Any process that modulates the frequency, rate or extent of protein localization to chromatin. - pga - 2016-11-01T16:33:52Z - regulation of protein localisation to chromatin + Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. + up regulation of hormone secretion + up-regulation of hormone secretion + upregulation of hormone secretion + activation of hormone secretion + stimulation of hormone secretion biological_process - GO:1905634 - regulation of protein localization to chromatin + GO:0046887 + positive regulation of hormone secretion - + - Any process that modulates the frequency, rate or extent of protein localization to chromatin. - GOC:TermGenie - GO_REF:0000058 - PMID:20889714 - - - - - regulation of protein localisation to chromatin - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. + GOC:ai - + - + - - + + - + + + + - - + + - Any process that modulates the frequency, rate or extent of artery morphogenesis. - rph - 2016-11-09T12:19:37Z - regulation of arterial morphogenesis - regulation of arteriogenesis + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. + down regulation of hormone secretion + down-regulation of hormone secretion + downregulation of hormone secretion + inhibition of hormone secretion biological_process - GO:1905651 - regulation of artery morphogenesis + GO:0046888 + negative regulation of hormone secretion - + - Any process that modulates the frequency, rate or extent of artery morphogenesis. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:27389411 - - - - - regulation of arterial morphogenesis - GOC:TermGenie - - - - - regulation of arteriogenesis - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. + GOC:ai - + - + - - + + - - + + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis. - rph - 2016-11-09T12:19:53Z - down regulation of arterial morphogenesis - down regulation of arteriogenesis - down regulation of artery morphogenesis - down-regulation of arterial morphogenesis - down-regulation of arteriogenesis - down-regulation of artery morphogenesis - downregulation of arterial morphogenesis - downregulation of arteriogenesis - downregulation of artery morphogenesis - negative regulation of arterial morphogenesis - negative regulation of arteriogenesis - inhibition of arterial morphogenesis - inhibition of arteriogenesis - inhibition of artery morphogenesis + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + positive regulation of lipid anabolism + positive regulation of lipid biosynthesis + positive regulation of lipid formation + positive regulation of lipid synthesis + positive regulation of lipogenesis + up regulation of lipid biosynthetic process + up-regulation of lipid biosynthetic process + upregulation of lipid biosynthetic process + activation of lipid biosynthetic process + stimulation of lipid biosynthetic process biological_process - GO:1905652 - negative regulation of artery morphogenesis + GO:0046889 + positive regulation of lipid biosynthetic process - + - Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:27389411 - - - - - down regulation of arterial morphogenesis - GOC:TermGenie - - - - - down regulation of arteriogenesis - GOC:TermGenie - - - - - down regulation of artery morphogenesis - GOC:TermGenie - - - - - down-regulation of arterial morphogenesis - GOC:TermGenie - - - - - down-regulation of arteriogenesis - GOC:TermGenie - - - - - down-regulation of artery morphogenesis - GOC:TermGenie - - - - - downregulation of arterial morphogenesis - GOC:TermGenie - - - - - downregulation of arteriogenesis - GOC:TermGenie - - - - - downregulation of artery morphogenesis - GOC:TermGenie - - - - - negative regulation of arterial morphogenesis - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + GOC:ai - + - negative regulation of arteriogenesis - GOC:TermGenie - - - - - inhibition of arterial morphogenesis - GOC:TermGenie - - - - - inhibition of arteriogenesis - GOC:TermGenie - - - - - inhibition of artery morphogenesis - GOC:TermGenie + positive regulation of lipogenesis + GOC:sl - + - + - - + + - - + + - - + + - Any process that activates or increases the frequency, rate or extent of artery morphogenesis. - rph - 2016-11-09T12:20:01Z - positive regulation of arterial morphogenesis - positive regulation of arteriogenesis - up regulation of arterial morphogenesis - up regulation of arteriogenesis - up regulation of artery morphogenesis - up-regulation of arterial morphogenesis - up-regulation of arteriogenesis - up-regulation of artery morphogenesis - upregulation of arterial morphogenesis - upregulation of arteriogenesis - upregulation of artery morphogenesis - activation of arterial morphogenesis - activation of arteriogenesis - activation of artery morphogenesis + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + regulation of lipid anabolism + regulation of lipid biosynthesis + regulation of lipid formation + regulation of lipid synthesis + regulation of lipogenesis biological_process - GO:1905653 - positive regulation of artery morphogenesis + GO:0046890 + regulation of lipid biosynthetic process - + - Any process that activates or increases the frequency, rate or extent of artery morphogenesis. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:27389411 - - - - - positive regulation of arterial morphogenesis - GOC:TermGenie - - - - - positive regulation of arteriogenesis - GOC:TermGenie - - - - - up regulation of arterial morphogenesis - GOC:TermGenie - - - - - up regulation of arteriogenesis - GOC:TermGenie - - - - - up regulation of artery morphogenesis - GOC:TermGenie - - - - - up-regulation of arterial morphogenesis - GOC:TermGenie - - - - - up-regulation of arteriogenesis - GOC:TermGenie - - - - - up-regulation of artery morphogenesis - GOC:TermGenie - - - - - upregulation of arterial morphogenesis - GOC:TermGenie + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + GOC:ai - + - upregulation of arteriogenesis - GOC:TermGenie + regulation of lipogenesis + GOC:sl + + + + + + + + The controlled release of a substance by a cell or a tissue. + biological_process + GO:0046903 + + secretion + - - - upregulation of artery morphogenesis - GOC:TermGenie + + + The controlled release of a substance by a cell or a tissue. + GOC:ai + + + + + + + + The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). + biological_process + GO:0046942 + carboxylic acid transport + - - - activation of arterial morphogenesis - GOC:TermGenie + + + The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). + GOC:ai + + + + + + + + + + The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system. + noradrenaline secretion + biological_process + GO:0048243 + norepinephrine secretion + - - - activation of arteriogenesis - GOC:TermGenie + + + The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system. + GOC:ef + GOC:jid + + + + + + + + + + + + + + The process in which the anatomical structures of the mesoderm are generated and organized. + biological_process + GO:0048332 + mesoderm morphogenesis + - - - activation of artery morphogenesis - GOC:TermGenie + + + The process in which the anatomical structures of the mesoderm are generated and organized. + GOC:go_curators - + - - - - - - - - - - - - - - + + + + + + + + + Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + Wikipedia:Organogenesis + development of an organ + organogenesis + biological_process + GO:0048513 + animal organ development + + + + + Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + GOC:dph + GOC:jid + + + + + + + + - - + + - The disaggregation of a nucleus into its constituent components. - pr - 2016-11-14T13:38:57Z - cell nucleus disassembly + The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. biological_process - GO:1905690 - nucleus disassembly + GO:0048514 + blood vessel morphogenesis - + - The disaggregation of a nucleus into its constituent components. - GOC:TermGenie - GOC:autophagy - GOC:pr - GO_REF:0000079 - - - - - cell nucleus disassembly - GOC:TermGenie + The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. + GOC:jid - + - + - + - - + + - + - - + + - Any microtubule bundle that is part of a cytoplasm. - mah - 2016-11-24T16:52:02Z - microtubule bundle of cytoplasm - microtubule fascicle of cytoplasm - cellular_component - GO:1905720 - cytoplasmic microtubule bundle + Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GO:0043119 + positive regulation of physiological process + up regulation of biological process + up-regulation of biological process + upregulation of biological process + activation of biological process + stimulation of biological process + biological_process + GO:0048518 + + positive regulation of biological process - + - Any microtubule bundle that is part of a cytoplasm. - GOC:TermGenie - GO_REF:0000064 - PMID:11007487 - PMID:26124291 - - - - - microtubule bundle of cytoplasm - GOC:TermGenie - - - - - microtubule fascicle of cytoplasm - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GOC:jid - + - + - + - - + + - + - - + + - A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule. - mah - 2016-12-12T15:31:07Z - protein localisation to cytoplasmic microtubule + Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GO:0043118 + down regulation of biological process + down-regulation of biological process + downregulation of biological process + negative regulation of physiological process + inhibition of biological process biological_process - GO:1905755 - protein localization to cytoplasmic microtubule + GO:0048519 + + negative regulation of biological process - + - A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule. - GOC:TermGenie - GO_REF:0000087 - PMID:15177031 - - - - - protein localisation to cytoplasmic microtubule - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GOC:jid - + - + - - + + - + + + - - + + - Any process that modulates the frequency, rate or extent of mesodermal cell differentiation. - rph - 2016-12-21T12:44:13Z - regulation of mesoderm cell differentiation + Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + up regulation of behavior + up-regulation of behavior + upregulation of behavior + activation of behavior + stimulation of behavior biological_process - GO:1905770 - regulation of mesodermal cell differentiation + GO:0048520 + positive regulation of behavior - + - Any process that modulates the frequency, rate or extent of mesodermal cell differentiation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:23765923 - - - - - regulation of mesoderm cell differentiation - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + GOC:jid + GOC:pr - + - + - + - - + + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation. - rph - 2016-12-21T12:44:23Z - down regulation of mesoderm cell differentiation - down regulation of mesodermal cell differentiation - down-regulation of mesoderm cell differentiation - down-regulation of mesodermal cell differentiation - downregulation of mesoderm cell differentiation - downregulation of mesodermal cell differentiation - negative regulation of mesoderm cell differentiation - inhibition of mesoderm cell differentiation - inhibition of mesodermal cell differentiation + Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + down regulation of behavior + down-regulation of behavior + downregulation of behavior + inhibition of behavior biological_process - GO:1905771 - negative regulation of mesodermal cell differentiation + GO:0048521 + negative regulation of behavior - + - Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:23765923 - - - - - down regulation of mesoderm cell differentiation - GOC:TermGenie - - - - - down regulation of mesodermal cell differentiation - GOC:TermGenie - - - - - down-regulation of mesoderm cell differentiation - GOC:TermGenie - - - - - down-regulation of mesodermal cell differentiation - GOC:TermGenie - - - - - downregulation of mesoderm cell differentiation - GOC:TermGenie - - - - - downregulation of mesodermal cell differentiation - GOC:TermGenie - - - - - negative regulation of mesoderm cell differentiation - GOC:TermGenie - - - - - inhibition of mesoderm cell differentiation - GOC:TermGenie - - - - - inhibition of mesodermal cell differentiation - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + GOC:jid + GOC:pr - + - + - + - - + + - + - Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation. - rph - 2016-12-21T12:44:32Z - positive regulation of mesoderm cell differentiation - up regulation of mesoderm cell differentiation - up regulation of mesodermal cell differentiation - up-regulation of mesoderm cell differentiation - up-regulation of mesodermal cell differentiation - upregulation of mesoderm cell differentiation - upregulation of mesodermal cell differentiation - activation of mesoderm cell differentiation - activation of mesodermal cell differentiation + Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GO:0051242 + positive regulation of cellular physiological process + up regulation of cellular process + up-regulation of cellular process + upregulation of cellular process + activation of cellular process + stimulation of cellular process biological_process - GO:1905772 - positive regulation of mesodermal cell differentiation + GO:0048522 + + positive regulation of cellular process - + - Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:23765923 - - - - - positive regulation of mesoderm cell differentiation - GOC:TermGenie - - - - - up regulation of mesoderm cell differentiation - GOC:TermGenie - - - - - up regulation of mesodermal cell differentiation - GOC:TermGenie - - - - - up-regulation of mesoderm cell differentiation - GOC:TermGenie - - - - - up-regulation of mesodermal cell differentiation - GOC:TermGenie - - - - - upregulation of mesoderm cell differentiation - GOC:TermGenie - - - - - upregulation of mesodermal cell differentiation - GOC:TermGenie - - - - - activation of mesoderm cell differentiation - GOC:TermGenie - - - - - activation of mesodermal cell differentiation - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GOC:jid - + - + - - + + - + + - - + + - Any process that modulates the frequency, rate or extent of synapse pruning. - tb - 2017-01-11T22:03:15Z - regulation of synapse clearance - regulation of synapse disassembly - regulation of synapse elimination - regulation of synapse removal + Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GO:0051243 + down regulation of cellular process + down-regulation of cellular process + downregulation of cellular process + negative regulation of cellular physiological process + inhibition of cellular process biological_process - GO:1905806 - - regulation of synapse pruning + GO:0048523 + + negative regulation of cellular process - + - Any process that modulates the frequency, rate or extent of synapse pruning. - GOC:TermGenie - GO_REF:0000058 - PMID:27779093 - - - - - regulation of synapse disassembly - + Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GOC:jid - + - - - - - - - - - - - - - - + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning. - tb - 2017-01-11T22:03:24Z - regulation of synapse clearance - regulation of synapse disassembly - regulation of synapse elimination - regulation of synapse removal - down regulation of synapse disassembly - down-regulation of synapse disassembly - downregulation of synapse disassembly - inhibition of synapse disassembly + The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. + haematopoietic or lymphoid organ development + haemopoietic or lymphoid organ development + hemopoietic or lymphoid organ development biological_process - GO:1905807 - negative regulation of synapse pruning + GO:0048534 + hematopoietic or lymphoid organ development - + - Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning. - GOC:TermGenie - GO_REF:0000058 - PMID:27779093 - - - - - down regulation of synapse disassembly - GOC:TermGenie - - - - - down-regulation of synapse disassembly - GOC:TermGenie - - - - - downregulation of synapse disassembly - GOC:TermGenie - - - - - inhibition of synapse disassembly - GOC:TermGenie + The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. + GOC:add + GOC:rl + ISBN:0781735149 - + - + - - + + - - + - - + + - Any process that activates or increases the frequency, rate or extent of synapse pruning. - tb - 2017-01-11T22:03:33Z - regulation of synapse clearance - regulation of synapse disassembly - regulation of synapse elimination - regulation of synapse removal - up regulation of synapse disassembly - up-regulation of synapse disassembly - upregulation of synapse disassembly - activation of synapse disassembly + Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. biological_process - GO:1905808 - positive regulation of synapse pruning + GO:0048580 + regulation of post-embryonic development - + - Any process that activates or increases the frequency, rate or extent of synapse pruning. - GOC:TermGenie - GO_REF:0000058 - PMID:27779093 - - - - - up regulation of synapse disassembly - GOC:TermGenie - - - - - up-regulation of synapse disassembly - GOC:TermGenie - - - - - upregulation of synapse disassembly - GOC:TermGenie - - - - - activation of synapse disassembly - GOC:TermGenie + Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + GOC:jid - + - + - + - - + + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization. - tb - 2017-01-11T22:03:41Z - down regulation of synapse development - down regulation of synapse organisation - down regulation of synapse organization - down-regulation of synapse development - down-regulation of synapse organisation - down-regulation of synapse organization - downregulation of synapse development - downregulation of synapse organisation - downregulation of synapse organization - negative regulation of synapse development - negative regulation of synapse organisation - inhibition of synapse development - inhibition of synapse organisation - inhibition of synapse organization + Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + down regulation of post-embryonic development + down-regulation of post-embryonic development + downregulation of post-embryonic development + inhibition of post-embryonic development biological_process - down regulation of synapse morphogenesis - down regulation of synapse organization and biogenesis - down-regulation of synapse morphogenesis - down-regulation of synapse organization and biogenesis - downregulation of synapse morphogenesis - downregulation of synapse organization and biogenesis - inhibition of synapse morphogenesis - inhibition of synapse organization and biogenesis - negative regulation of synapse morphogenesis - negative regulation of synapse organization and biogenesis - GO:1905809 - negative regulation of synapse organization - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization. - GOC:TermGenie - GO_REF:0000058 - PMID:27779093 - - - - - down regulation of synapse development - GOC:TermGenie - - - - - down regulation of synapse organisation - GOC:TermGenie - - - - - down regulation of synapse organization - GOC:TermGenie - - - - - down-regulation of synapse development - GOC:TermGenie - - - - - down-regulation of synapse organisation - GOC:TermGenie - - - - - down-regulation of synapse organization - GOC:TermGenie - - - - - downregulation of synapse development - GOC:TermGenie - - - - - downregulation of synapse organisation - GOC:TermGenie - - - - - downregulation of synapse organization - GOC:TermGenie - - - - - negative regulation of synapse development - GOC:TermGenie - - - - - negative regulation of synapse organisation - GOC:TermGenie - - - - - inhibition of synapse development - GOC:TermGenie - - - - - inhibition of synapse organisation - GOC:TermGenie - - - - - inhibition of synapse organization - GOC:TermGenie - - - - - down regulation of synapse morphogenesis - GOC:TermGenie - - - - - down regulation of synapse organization and biogenesis - GOC:TermGenie - - - - - down-regulation of synapse morphogenesis - GOC:TermGenie - - - - - down-regulation of synapse organization and biogenesis - GOC:TermGenie - - - - - downregulation of synapse morphogenesis - GOC:TermGenie - - - - - downregulation of synapse organization and biogenesis - GOC:TermGenie - - - - - inhibition of synapse morphogenesis - GOC:TermGenie - - - - - inhibition of synapse organization and biogenesis - GOC:TermGenie - - - - - negative regulation of synapse morphogenesis - GOC:TermGenie - + GO:0048581 + negative regulation of post-embryonic development + - - - negative regulation of synapse organization and biogenesis - GOC:TermGenie + + + Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + GOC:jid - + - + - + - - + + + - + - Any process that activates or increases the frequency, rate or extent of chromosome condensation. - bhm - 2017-01-13T14:13:44Z - positive regulation of eukaryotic chromosome condensation - positive regulation of nuclear chromosome condensation - up regulation of chromosome condensation - up regulation of eukaryotic chromosome condensation - up regulation of nuclear chromosome condensation - up-regulation of chromosome condensation - up-regulation of eukaryotic chromosome condensation - up-regulation of nuclear chromosome condensation - upregulation of chromosome condensation - upregulation of eukaryotic chromosome condensation - upregulation of nuclear chromosome condensation - activation of chromosome condensation - activation of eukaryotic chromosome condensation - activation of nuclear chromosome condensation + Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + up regulation of post-embryonic development + up-regulation of post-embryonic development + upregulation of post-embryonic development + activation of post-embryonic development + stimulation of post-embryonic development biological_process - GO:1905821 - positive regulation of chromosome condensation + GO:0048582 + positive regulation of post-embryonic development - + - Any process that activates or increases the frequency, rate or extent of chromosome condensation. - GOC:TermGenie - GOC:bhm - GO_REF:0000058 - PMID:17268547 - - - - - positive regulation of eukaryotic chromosome condensation - GOC:TermGenie - - - - - positive regulation of nuclear chromosome condensation - GOC:TermGenie - - - - - up regulation of chromosome condensation - GOC:TermGenie - - - - - up regulation of eukaryotic chromosome condensation - GOC:TermGenie - - - - - up regulation of nuclear chromosome condensation - GOC:TermGenie - - - - - up-regulation of chromosome condensation - GOC:TermGenie - - - - - up-regulation of eukaryotic chromosome condensation - GOC:TermGenie - - - - - up-regulation of nuclear chromosome condensation - GOC:TermGenie - - - - - upregulation of chromosome condensation - GOC:TermGenie - - - - - upregulation of eukaryotic chromosome condensation - GOC:TermGenie - - - - - upregulation of nuclear chromosome condensation - GOC:TermGenie - - - - - activation of chromosome condensation - GOC:TermGenie - - - - - activation of eukaryotic chromosome condensation - GOC:TermGenie - - - - - activation of nuclear chromosome condensation - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + GOC:jid - + - + - - + + - - - - - - - - + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation. - hbye - 2017-01-17T12:00:56Z - down regulation of microtubule nucleation - down-regulation of microtubule nucleation - downregulation of microtubule nucleation - inhibition of microtubule nucleation + Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. biological_process - GO:1905833 - negative regulation of microtubule nucleation + GO:0048583 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + regulation of response to stimulus - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation. - GOC:TermGenie - GO_REF:0000058 - PMID:27689799 - - - - - down regulation of microtubule nucleation - GOC:TermGenie - - - - - down-regulation of microtubule nucleation - GOC:TermGenie - - - - - downregulation of microtubule nucleation - GOC:TermGenie - - - - - inhibition of microtubule nucleation - GOC:TermGenie + Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + GOC:jid - + - + - - + + - + + - - + + - Any process that modulates the frequency, rate or extent of protein localization to cell leading edge. - sl - 2017-01-27T19:34:55Z - regulation of protein localisation in cell leading edge - regulation of protein localisation to cell leading edge - regulation of protein localization in cell leading edge + Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + up regulation of response to stimulus + up-regulation of response to stimulus + upregulation of response to stimulus + activation of response to stimulus + stimulation of response to stimulus biological_process - GO:1905871 - regulation of protein localization to cell leading edge + GO:0048584 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + positive regulation of response to stimulus - + - Any process that modulates the frequency, rate or extent of protein localization to cell leading edge. - GOC:TermGenie - GO_REF:0000058 - PMID:26324884 - - - - - regulation of protein localisation in cell leading edge - GOC:TermGenie - - - - - regulation of protein localisation to cell leading edge - GOC:TermGenie - - - - - regulation of protein localization in cell leading edge - GOC:TermGenie + Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + GOC:jid - + - + - + - - + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge. - sl - 2017-01-27T19:35:04Z - down regulation of protein localisation in cell leading edge - down regulation of protein localisation to cell leading edge - down regulation of protein localization in cell leading edge - down regulation of protein localization to cell leading edge - down-regulation of protein localisation in cell leading edge - down-regulation of protein localisation to cell leading edge - down-regulation of protein localization in cell leading edge - down-regulation of protein localization to cell leading edge - downregulation of protein localisation in cell leading edge - downregulation of protein localisation to cell leading edge - downregulation of protein localization in cell leading edge - downregulation of protein localization to cell leading edge - negative regulation of protein localisation in cell leading edge - negative regulation of protein localisation to cell leading edge - negative regulation of protein localization in cell leading edge - inhibition of protein localisation in cell leading edge - inhibition of protein localisation to cell leading edge - inhibition of protein localization in cell leading edge - inhibition of protein localization to cell leading edge + Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + down regulation of response to stimulus + down-regulation of response to stimulus + downregulation of response to stimulus + inhibition of response to stimulus biological_process - GO:1905872 - negative regulation of protein localization to cell leading edge + GO:0048585 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + negative regulation of response to stimulus - + - Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge. - GOC:TermGenie - GO_REF:0000058 - PMID:26324884 - - - - - down regulation of protein localisation in cell leading edge - GOC:TermGenie - - - - - down regulation of protein localisation to cell leading edge - GOC:TermGenie - - - - - down regulation of protein localization in cell leading edge - GOC:TermGenie - - - - - down regulation of protein localization to cell leading edge - GOC:TermGenie - - - - - down-regulation of protein localisation in cell leading edge - GOC:TermGenie - - - - - down-regulation of protein localisation to cell leading edge - GOC:TermGenie - - - - - down-regulation of protein localization in cell leading edge - GOC:TermGenie - - - - - down-regulation of protein localization to cell leading edge - GOC:TermGenie - - - - - downregulation of protein localisation in cell leading edge - GOC:TermGenie - - - - - downregulation of protein localisation to cell leading edge - GOC:TermGenie - - - - - downregulation of protein localization in cell leading edge - GOC:TermGenie - - - - - downregulation of protein localization to cell leading edge - GOC:TermGenie - - - - - negative regulation of protein localisation in cell leading edge - GOC:TermGenie - - - - - negative regulation of protein localisation to cell leading edge - GOC:TermGenie - - - - - negative regulation of protein localization in cell leading edge - GOC:TermGenie - - - - - inhibition of protein localisation in cell leading edge - GOC:TermGenie - - - - - inhibition of protein localisation to cell leading edge - GOC:TermGenie - - - - - inhibition of protein localization in cell leading edge - GOC:TermGenie - - - - - inhibition of protein localization to cell leading edge - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + GOC:jid - + - - - - - - - - - - - - - - + + - - + + - Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge. - sl - 2017-01-27T19:35:13Z - positive regulation of protein localisation in cell leading edge - positive regulation of protein localisation to cell leading edge - positive regulation of protein localization in cell leading edge - up regulation of protein localisation in cell leading edge - up regulation of protein localisation to cell leading edge - up regulation of protein localization in cell leading edge - up regulation of protein localization to cell leading edge - up-regulation of protein localisation in cell leading edge - up-regulation of protein localisation to cell leading edge - up-regulation of protein localization in cell leading edge - up-regulation of protein localization to cell leading edge - upregulation of protein localisation in cell leading edge - upregulation of protein localisation to cell leading edge - upregulation of protein localization in cell leading edge - upregulation of protein localization to cell leading edge - activation of protein localisation in cell leading edge - activation of protein localisation to cell leading edge - activation of protein localization in cell leading edge - activation of protein localization to cell leading edge + The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. + GO:0048828 + embryonic anatomical structure morphogenesis biological_process - GO:1905873 - positive regulation of protein localization to cell leading edge + GO:0048598 + embryonic morphogenesis - + - Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge. - GOC:TermGenie - GO_REF:0000058 - PMID:26324884 - - - - - positive regulation of protein localisation in cell leading edge - GOC:TermGenie - - - - - positive regulation of protein localisation to cell leading edge - GOC:TermGenie - - - - - positive regulation of protein localization in cell leading edge - GOC:TermGenie - - - - - up regulation of protein localisation in cell leading edge - GOC:TermGenie - - - - - up regulation of protein localisation to cell leading edge - GOC:TermGenie - - - - - up regulation of protein localization in cell leading edge - GOC:TermGenie - - - - - up regulation of protein localization to cell leading edge - GOC:TermGenie - - - - - up-regulation of protein localisation in cell leading edge - GOC:TermGenie - - - - - up-regulation of protein localisation to cell leading edge - GOC:TermGenie - - - - - up-regulation of protein localization in cell leading edge - GOC:TermGenie - - - - - up-regulation of protein localization to cell leading edge - GOC:TermGenie - - - - - upregulation of protein localisation in cell leading edge - GOC:TermGenie - - - - - upregulation of protein localisation to cell leading edge - GOC:TermGenie - - - - - upregulation of protein localization in cell leading edge - GOC:TermGenie + The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. + GOC:jid + GOC:mtg_sensu - + - upregulation of protein localization to cell leading edge - GOC:TermGenie - - - - - activation of protein localisation in cell leading edge - GOC:TermGenie - - - - - activation of protein localisation to cell leading edge - GOC:TermGenie - - - - - activation of protein localization in cell leading edge - GOC:TermGenie - - - - - activation of protein localization to cell leading edge - GOC:TermGenie + embryonic anatomical structure morphogenesis + GOC:dph + GOC:tb - + - - - - - - - - - - - - - - - - - - - - - + + - - + + - Any process that modulates the frequency, rate or extent of oogenesis. - hbye - 2017-01-31T09:31:05Z - regulation of ovum development + The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. + organismal reproductive process + reproductive process in a multicellular organism biological_process - GO:1905879 - regulation of oogenesis + GO:0048609 + multicellular organismal reproductive process - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that modulates the frequency, rate or extent of oogenesis. - GOC:TermGenie - GO_REF:0000058 - PMID:26434723 - - - - - regulation of ovum development - GOC:TermGenie + The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. + GOC:dph + GOC:jid + GOC:tb - + - - - - - - - - - - - - - - - - + + - - + + - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis. - hbye - 2017-01-31T09:31:15Z - down regulation of oogenesis - down regulation of ovum development - down-regulation of oogenesis - down-regulation of ovum development - downregulation of oogenesis - downregulation of ovum development - negative regulation of ovum development - inhibition of oogenesis - inhibition of ovum development + The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + formation of an anatomical structure involved in morphogenesis biological_process - GO:1905880 - negative regulation of oogenesis + GO:0048646 + + Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. + anatomical structure formation involved in morphogenesis - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis. - GOC:TermGenie - GO_REF:0000058 - PMID:26434723 - - - - - down regulation of oogenesis - GOC:TermGenie - - - - - down regulation of ovum development - GOC:TermGenie - - - - - down-regulation of oogenesis - GOC:TermGenie - - - - - down-regulation of ovum development - GOC:TermGenie - - - - - downregulation of oogenesis - GOC:TermGenie - - - - - downregulation of ovum development - GOC:TermGenie + The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + GOC:dph + GOC:jid + GOC:tb - + - negative regulation of ovum development - GOC:TermGenie - - - - - inhibition of oogenesis - GOC:TermGenie - - - - - inhibition of ovum development - GOC:TermGenie + formation of an anatomical structure involved in morphogenesis + GOC:dph + GOC:tb - + - - - - - - - - - - - - - - - - + + - - + + - - - - - - - Any process that activates or increases the frequency, rate or extent of oogenesis. - hbye - 2017-01-31T09:31:23Z - positive regulation of ovum development - up regulation of oogenesis - up regulation of ovum development - up-regulation of oogenesis - up-regulation of ovum development - upregulation of oogenesis - upregulation of ovum development - activation of oogenesis - activation of ovum development + The process in which the anatomical structures of a tissue are generated and organized. biological_process - GO:1905881 - positive regulation of oogenesis + GO:0048729 + tissue morphogenesis - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that activates or increases the frequency, rate or extent of oogenesis. - GOC:TermGenie - GO_REF:0000058 - PMID:26434723 - - - - - positive regulation of ovum development - GOC:TermGenie - - - - - up regulation of oogenesis - GOC:TermGenie - - - - - up regulation of ovum development - GOC:TermGenie - - - - - up-regulation of oogenesis - GOC:TermGenie - - - - - up-regulation of ovum development - GOC:TermGenie - - - - - upregulation of oogenesis - GOC:TermGenie - - - - - upregulation of ovum development - GOC:TermGenie - - - - - activation of oogenesis - GOC:TermGenie - - - - - activation of ovum development - GOC:TermGenie + The process in which the anatomical structures of a tissue are generated and organized. + GOC:dph + GOC:jid - + - - - - - - - - - - - - - + + - - + + - Any process that modulates the frequency, rate or extent of smooth muscle tissue development. - bhm - 2017-02-01T14:31:16Z + The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. biological_process - GO:1905899 - regulation of smooth muscle tissue development + GO:0048731 + + system development - + - Any process that modulates the frequency, rate or extent of smooth muscle tissue development. - GOC:TermGenie - GOC:bhm - GO_REF:0000058 - PMID:14709716 + The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. + GOC:dph + GOC:jid - + - - - - - - - - - - - - - - + + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development. - bhm - 2017-02-01T14:31:24Z - down regulation of smooth muscle tissue development - down-regulation of smooth muscle tissue development - downregulation of smooth muscle tissue development - inhibition of smooth muscle tissue development + The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. biological_process - GO:1905900 - negative regulation of smooth muscle tissue development + tubulogenesis + GO:0048754 + branching morphogenesis of an epithelial tube - + - Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development. - GOC:TermGenie - GOC:bhm - GO_REF:0000058 - PMID:14709716 - - - - - down regulation of smooth muscle tissue development - GOC:TermGenie - - - - - down-regulation of smooth muscle tissue development - GOC:TermGenie + The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. + GOC:dgh + GOC:dph + GOC:jid - - - downregulation of smooth muscle tissue development - GOC:TermGenie + + + tubulogenesis + GOC:dph + GOC:tb + + + + + + + + A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. + cellular_component + GO:0048770 + pigment granule + - - - inhibition of smooth muscle tissue development - GOC:TermGenie + + + A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. + GOC:jid + GOC:mh - + - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development. - bhm - 2017-02-01T14:31:33Z - up regulation of smooth muscle tissue development - up-regulation of smooth muscle tissue development - upregulation of smooth muscle tissue development - activation of smooth muscle tissue development + + + The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + development of an anatomical structure biological_process - GO:1905901 - positive regulation of smooth muscle tissue development + GO:0048856 + + + + anatomical structure development - + - Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development. - GOC:TermGenie - GOC:bhm - GO_REF:0000058 - PMID:14709716 - - - - - up regulation of smooth muscle tissue development - GOC:TermGenie - - - - - up-regulation of smooth muscle tissue development - GOC:TermGenie - - - - - upregulation of smooth muscle tissue development - GOC:TermGenie - - - - - activation of smooth muscle tissue development - GOC:TermGenie + The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + GO_REF:0000021 - + - - - - - - - - - - - - - + + + - - + + - Any process that modulates the frequency, rate or extent of mesoderm formation. - rph - 2017-02-03T12:28:20Z + Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. + https://github.com/geneontology/go-ontology/issues/19809 + cell locomotion + movement of a cell + biological_process + cell movement + GO:0048870 + + + + + cell motility + + + + + Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. + GOC:dgh + GOC:dph + GOC:isa_complete + GOC:mlg + + + + + + + + + + Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. biological_process - GO:1905902 - regulation of mesoderm formation + GO:0048871 + multicellular organismal homeostasis - + - Any process that modulates the frequency, rate or extent of mesoderm formation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:23939491 + Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. + GOC:isa_complete - + - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation. - rph - 2017-02-03T12:28:29Z - down regulation of mesoderm formation - down-regulation of mesoderm formation - downregulation of mesoderm formation - inhibition of mesoderm formation + + + + The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. biological_process - GO:1905903 - negative regulation of mesoderm formation + GO:0050432 + catecholamine secretion - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:23939491 - - - - - down regulation of mesoderm formation - GOC:TermGenie - - - - - down-regulation of mesoderm formation - GOC:TermGenie - - - - - downregulation of mesoderm formation - GOC:TermGenie - - - - - inhibition of mesoderm formation - GOC:TermGenie + The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + GOC:ai + GOC:ef - + - + - - + + - - - - - - - - + + - - + + - Any process that activates or increases the frequency, rate or extent of mesoderm formation. - rph - 2017-02-03T12:28:38Z - up regulation of mesoderm formation - up-regulation of mesoderm formation - upregulation of mesoderm formation - activation of mesoderm formation + Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. biological_process - GO:1905904 - positive regulation of mesoderm formation + GO:0050433 + regulation of catecholamine secretion - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that activates or increases the frequency, rate or extent of mesoderm formation. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:23939491 - - - - - up regulation of mesoderm formation - GOC:TermGenie - - - - - up-regulation of mesoderm formation - GOC:TermGenie - - - - - upregulation of mesoderm formation - GOC:TermGenie - - - - - activation of mesoderm formation - GOC:TermGenie + Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. + GOC:ai - + - + - + - - + + - + - Any process that modulates the frequency, rate or extent of acetylcholine biosynthetic process. - bc - 2017-02-08T13:08:30Z - regulation of acetylcholine anabolism - regulation of acetylcholine biosynthesis - regulation of acetylcholine formation - regulation of acetylcholine synthesis + Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. biological_process - GO:1905921 - regulation of acetylcholine biosynthetic process + GO:0050708 + regulation of protein secretion - + - Any process that modulates the frequency, rate or extent of acetylcholine biosynthetic process. - GOC:TermGenie - GOC:aruk - GOC:bc - GO_REF:0000058 - PMID:20164328 - - - - - regulation of acetylcholine anabolism - GOC:TermGenie - - - - - regulation of acetylcholine biosynthesis - GOC:TermGenie - - - - - regulation of acetylcholine formation - GOC:TermGenie - - - - - regulation of acetylcholine synthesis - GOC:TermGenie + Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. + GOC:ai - + - + - + - - - + + + - - - - Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine biosynthetic process. - bc - 2017-02-08T13:08:39Z - down regulation of acetylcholine anabolism - down regulation of acetylcholine biosynthesis - down regulation of acetylcholine biosynthetic process - down regulation of acetylcholine formation - down regulation of acetylcholine synthesis - down-regulation of acetylcholine anabolism - down-regulation of acetylcholine biosynthesis - down-regulation of acetylcholine biosynthetic process - down-regulation of acetylcholine formation - down-regulation of acetylcholine synthesis - downregulation of acetylcholine anabolism - downregulation of acetylcholine biosynthesis - downregulation of acetylcholine biosynthetic process - downregulation of acetylcholine formation - downregulation of acetylcholine synthesis - negative regulation of acetylcholine anabolism - negative regulation of acetylcholine biosynthesis - negative regulation of acetylcholine formation - negative regulation of acetylcholine synthesis - inhibition of acetylcholine anabolism - inhibition of acetylcholine biosynthesis - inhibition of acetylcholine biosynthetic process - inhibition of acetylcholine formation - inhibition of acetylcholine synthesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. + down regulation of protein secretion + down-regulation of protein secretion + downregulation of protein secretion + inhibition of protein secretion biological_process - GO:1905922 - negative regulation of acetylcholine biosynthetic process + GO:0050709 + negative regulation of protein secretion - + - Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine biosynthetic process. - GOC:TermGenie - GOC:aruk - GOC:bc - GO_REF:0000058 - PMID:20164328 - - - - - down regulation of acetylcholine anabolism - GOC:TermGenie - - - - - down regulation of acetylcholine biosynthesis - GOC:TermGenie - - - - - down regulation of acetylcholine biosynthetic process - GOC:TermGenie - - - - - down regulation of acetylcholine formation - GOC:TermGenie - - - - - down regulation of acetylcholine synthesis - GOC:TermGenie - - - - - down-regulation of acetylcholine anabolism - GOC:TermGenie - - - - - down-regulation of acetylcholine biosynthesis - GOC:TermGenie - - - - - down-regulation of acetylcholine biosynthetic process - GOC:TermGenie - - - - - down-regulation of acetylcholine formation - GOC:TermGenie - - - - - down-regulation of acetylcholine synthesis - GOC:TermGenie - - - - - downregulation of acetylcholine anabolism - GOC:TermGenie - - - - - downregulation of acetylcholine biosynthesis - GOC:TermGenie - - - - - downregulation of acetylcholine biosynthetic process - GOC:TermGenie - - - - - downregulation of acetylcholine formation - GOC:TermGenie - - - - - downregulation of acetylcholine synthesis - GOC:TermGenie - - - - - negative regulation of acetylcholine anabolism - GOC:TermGenie - - - - - negative regulation of acetylcholine biosynthesis - GOC:TermGenie - - - - - negative regulation of acetylcholine formation - GOC:TermGenie - - - - - negative regulation of acetylcholine synthesis - GOC:TermGenie - - - - - inhibition of acetylcholine anabolism - GOC:TermGenie - - - - - inhibition of acetylcholine biosynthesis - GOC:TermGenie - - - - - inhibition of acetylcholine biosynthetic process - GOC:TermGenie - - - - - inhibition of acetylcholine formation - GOC:TermGenie - - - - - inhibition of acetylcholine synthesis - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. + GOC:ai - + - + - + - - - + + + - - - - Any process that activates or increases the frequency, rate or extent of acetylcholine biosynthetic process. - bc - 2017-02-08T13:08:48Z - positive regulation of acetylcholine anabolism - positive regulation of acetylcholine biosynthesis - positive regulation of acetylcholine formation - positive regulation of acetylcholine synthesis - up regulation of acetylcholine anabolism - up regulation of acetylcholine biosynthesis - up regulation of acetylcholine biosynthetic process - up regulation of acetylcholine formation - up regulation of acetylcholine synthesis - up-regulation of acetylcholine anabolism - up-regulation of acetylcholine biosynthesis - up-regulation of acetylcholine biosynthetic process - up-regulation of acetylcholine formation - up-regulation of acetylcholine synthesis - upregulation of acetylcholine anabolism - upregulation of acetylcholine biosynthesis - upregulation of acetylcholine biosynthetic process - upregulation of acetylcholine formation - upregulation of acetylcholine synthesis - activation of acetylcholine anabolism - activation of acetylcholine biosynthesis - activation of acetylcholine biosynthetic process - activation of acetylcholine formation - activation of acetylcholine synthesis + + + + Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. + up regulation of protein secretion + up-regulation of protein secretion + upregulation of protein secretion + activation of protein secretion + stimulation of protein secretion biological_process - GO:1905923 - positive regulation of acetylcholine biosynthetic process + GO:0050714 + positive regulation of protein secretion - + - Any process that activates or increases the frequency, rate or extent of acetylcholine biosynthetic process. - GOC:TermGenie - GOC:aruk - GOC:bc - GO_REF:0000058 - PMID:20164328 - - - - - positive regulation of acetylcholine anabolism - GOC:TermGenie - - - - - positive regulation of acetylcholine biosynthesis - GOC:TermGenie - - - - - positive regulation of acetylcholine formation - GOC:TermGenie - - - - - positive regulation of acetylcholine synthesis - GOC:TermGenie - - - - - up regulation of acetylcholine anabolism - GOC:TermGenie - - - - - up regulation of acetylcholine biosynthesis - GOC:TermGenie - - - - - up regulation of acetylcholine biosynthetic process - GOC:TermGenie - - - - - up regulation of acetylcholine formation - GOC:TermGenie - - - - - up regulation of acetylcholine synthesis - GOC:TermGenie - - - - - up-regulation of acetylcholine anabolism - GOC:TermGenie - - - - - up-regulation of acetylcholine biosynthesis - GOC:TermGenie - - - - - up-regulation of acetylcholine biosynthetic process - GOC:TermGenie - - - - - up-regulation of acetylcholine formation - GOC:TermGenie - - - - - up-regulation of acetylcholine synthesis - GOC:TermGenie - - - - - upregulation of acetylcholine anabolism - GOC:TermGenie - - - - - upregulation of acetylcholine biosynthesis - GOC:TermGenie - - - - - upregulation of acetylcholine biosynthetic process - GOC:TermGenie - - - - - upregulation of acetylcholine formation - GOC:TermGenie - - - - - upregulation of acetylcholine synthesis - GOC:TermGenie - - - - - activation of acetylcholine anabolism - GOC:TermGenie - - - - - activation of acetylcholine biosynthesis - GOC:TermGenie - - - - - activation of acetylcholine biosynthetic process - GOC:TermGenie - - - - - activation of acetylcholine formation - GOC:TermGenie - - - - - activation of acetylcholine synthesis - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. + GOC:ai - + - + - + - - - - - - - - - + + - + - Any process that modulates the frequency, rate or extent of germ cell proliferation. - hbye - 2017-02-09T14:51:31Z + Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. biological_process - GO:1905936 - regulation of germ cell proliferation + GO:0050776 + regulation of immune response - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that modulates the frequency, rate or extent of germ cell proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:15342467 + Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + GOC:ai - + - + - + - - - - - - - - - - + + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation. - hbye - 2017-02-09T14:51:41Z - down regulation of germ cell proliferation - down-regulation of germ cell proliferation - downregulation of germ cell proliferation - inhibition of germ cell proliferation + Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + down regulation of immune response + down-regulation of immune response + downregulation of immune response + inhibition of immune response biological_process - GO:1905937 - negative regulation of germ cell proliferation + GO:0050777 + negative regulation of immune response - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:15342467 - - - - - down regulation of germ cell proliferation - GOC:TermGenie - - - - - down-regulation of germ cell proliferation - GOC:TermGenie - - - - - downregulation of germ cell proliferation - GOC:TermGenie - - - - - inhibition of germ cell proliferation - GOC:TermGenie + Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + GOC:ai - + - + - + - - - - - - - - - - + + + - + - Any process that activates or increases the frequency, rate or extent of germ cell proliferation. - hbye - 2017-02-09T14:51:51Z - up regulation of germ cell proliferation - up-regulation of germ cell proliferation - upregulation of germ cell proliferation - activation of germ cell proliferation + Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + up regulation of immune response + up-regulation of immune response + upregulation of immune response + stimulation of immune response biological_process - GO:1905938 - positive regulation of germ cell proliferation + GO:0050778 + positive regulation of immune response - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that activates or increases the frequency, rate or extent of germ cell proliferation. - GOC:TermGenie - GO_REF:0000058 - PMID:15342467 - - - - - up regulation of germ cell proliferation - GOC:TermGenie - - - - - up-regulation of germ cell proliferation - GOC:TermGenie - - - - - upregulation of germ cell proliferation - GOC:TermGenie - - - - - activation of germ cell proliferation - GOC:TermGenie + Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + GOC:ai - + - + - + - - + - + - Any process that modulates the frequency, rate or extent of gonad development. - hbye - 2017-02-09T17:01:50Z - regulation of gonadogenesis + Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GO:0050791 + regulation of physiological process biological_process - GO:1905939 - regulation of gonad development + GO:0050789 + + + + + regulation of biological process - + - Any process that modulates the frequency, rate or extent of gonad development. - GOC:TermGenie - GO_REF:0000058 - PMID:15342467 - - - - - regulation of gonadogenesis - GOC:TermGenie + Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GOC:ai + GOC:go_curators - + - + - - + + - - - - - - - - - - + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of gonad development. - hbye - 2017-02-09T17:01:59Z - down regulation of gonad development - down regulation of gonadogenesis - down-regulation of gonad development - down-regulation of gonadogenesis - downregulation of gonad development - downregulation of gonadogenesis - negative regulation of gonadogenesis - inhibition of gonad development - inhibition of gonadogenesis + Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). biological_process - GO:1905940 - negative regulation of gonad development + GO:0050793 + regulation of developmental process - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that stops, prevents or reduces the frequency, rate or extent of gonad development. - GOC:TermGenie - GO_REF:0000058 - PMID:15342467 - - - - - down regulation of gonad development - GOC:TermGenie - - - - - down regulation of gonadogenesis - GOC:TermGenie - - - - - down-regulation of gonad development - GOC:TermGenie - - - - - down-regulation of gonadogenesis - GOC:TermGenie - - - - - downregulation of gonad development - GOC:TermGenie - - - - - downregulation of gonadogenesis - GOC:TermGenie - - - - - negative regulation of gonadogenesis - GOC:TermGenie - - - - - inhibition of gonad development - GOC:TermGenie - - - - - inhibition of gonadogenesis - GOC:TermGenie + Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + GOC:go_curators - + - + - - + + - - - - - - - - - - + - - + + - Any process that activates or increases the frequency, rate or extent of gonad development. - hbye - 2017-02-09T17:02:08Z - positive regulation of gonadogenesis - up regulation of gonad development - up regulation of gonadogenesis - up-regulation of gonad development - up-regulation of gonadogenesis - upregulation of gonad development - upregulation of gonadogenesis - activation of gonad development - activation of gonadogenesis + Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GO:0051244 + regulation of cellular physiological process biological_process - GO:1905941 - positive regulation of gonad development + GO:0050794 + + regulation of cellular process - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that activates or increases the frequency, rate or extent of gonad development. - GOC:TermGenie - GO_REF:0000058 - PMID:15342467 - - - - - positive regulation of gonadogenesis - GOC:TermGenie - - - - - up regulation of gonad development - GOC:TermGenie - - - - - up regulation of gonadogenesis - GOC:TermGenie - - - - - up-regulation of gonad development - GOC:TermGenie - - - - - up-regulation of gonadogenesis - GOC:TermGenie - - - - - upregulation of gonad development - GOC:TermGenie - - - - - upregulation of gonadogenesis - GOC:TermGenie - - - - - activation of gonad development - GOC:TermGenie - - - - - activation of gonadogenesis - GOC:TermGenie + Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GOC:go_curators - + - + - + - + + - + - Any process that modulates the frequency, rate or extent of lipid localization. - rz - 2017-02-21T12:12:22Z - regulation of lipid localisation + Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + regulation of behaviour biological_process - GO:1905952 - regulation of lipid localization + GO:0050795 + regulation of behavior - + - Any process that modulates the frequency, rate or extent of lipid localization. - GOC:TermGenie - GO_REF:0000058 - PMID:17564681 - - - - - regulation of lipid localisation - GOC:TermGenie + Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + GOC:go_curators + GOC:pr - + - + - - + + - - + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. - rz - 2017-02-21T12:12:41Z - down regulation of lipid localisation - down regulation of lipid localization - down-regulation of lipid localisation - down-regulation of lipid localization - downregulation of lipid localisation - downregulation of lipid localization - negative regulation of lipid localisation - inhibition of lipid localisation - inhibition of lipid localization + Any process that modulates the frequency, rate or extent of the regulated release of insulin. biological_process - GO:1905953 - negative regulation of lipid localization + GO:0050796 + regulation of insulin secretion - + - Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. - GOC:TermGenie - GO_REF:0000058 - PMID:17564681 - - - - - down regulation of lipid localisation - GOC:TermGenie - - - - - down regulation of lipid localization - GOC:TermGenie - - - - - down-regulation of lipid localisation - GOC:TermGenie - - - - - down-regulation of lipid localization - GOC:TermGenie - - - - - downregulation of lipid localisation - GOC:TermGenie - - - - - downregulation of lipid localization - GOC:TermGenie - - - - - negative regulation of lipid localisation - GOC:TermGenie - - - - - inhibition of lipid localisation - GOC:TermGenie - - - - - inhibition of lipid localization - GOC:TermGenie + Any process that modulates the frequency, rate or extent of the regulated release of insulin. + GOC:ai - + - + - - + + - - + + - - + + - Any process that activates or increases the frequency, rate or extent of lipid localization. - rz - 2017-02-21T12:12:49Z - positive regulation of lipid localisation - up regulation of lipid localisation - up regulation of lipid localization - up-regulation of lipid localisation - up-regulation of lipid localization - upregulation of lipid localisation - upregulation of lipid localization - activation of lipid localisation - activation of lipid localization + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + regulation of steroid anabolism + regulation of steroid biosynthesis + regulation of steroid formation + regulation of steroid synthesis + regulation of steroidogenesis biological_process - GO:1905954 - positive regulation of lipid localization + GO:0050810 + regulation of steroid biosynthetic process - + - Any process that activates or increases the frequency, rate or extent of lipid localization. - GOC:TermGenie - GO_REF:0000058 - PMID:17564681 - - - - - positive regulation of lipid localisation - GOC:TermGenie - - - - - up regulation of lipid localisation - GOC:TermGenie - - - - - up regulation of lipid localization - GOC:TermGenie - - - - - up-regulation of lipid localisation - GOC:TermGenie - - - - - up-regulation of lipid localization - GOC:TermGenie - - - - - upregulation of lipid localisation - GOC:TermGenie - - - - - upregulation of lipid localization - GOC:TermGenie - - - - - activation of lipid localisation - GOC:TermGenie - - - - - activation of lipid localization - GOC:TermGenie + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + GOC:ai - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis. - rph - 2017-02-21T15:17:31Z - down regulation of endothelial tube morphogenesis - down-regulation of endothelial tube morphogenesis - downregulation of endothelial tube morphogenesis - inhibition of endothelial tube morphogenesis + + + A organ system process carried out by any of the organs or tissues of neurological system. + https://github.com/geneontology/go-ontology/issues/13824 + neurological system process + neurophysiological process biological_process - GO:1905955 - negative regulation of endothelial tube morphogenesis + pan-neural process + GO:0050877 + + + + + + nervous system process - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:25961718 - - - - - down regulation of endothelial tube morphogenesis - GOC:TermGenie - - - - - down-regulation of endothelial tube morphogenesis - GOC:TermGenie - - - - - downregulation of endothelial tube morphogenesis - GOC:TermGenie - - - - - inhibition of endothelial tube morphogenesis - GOC:TermGenie + A organ system process carried out by any of the organs or tissues of neurological system. + GOC:ai + GOC:mtg_cardio - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis. - rph - 2017-02-21T15:17:39Z - up regulation of endothelial tube morphogenesis - up-regulation of endothelial tube morphogenesis - upregulation of endothelial tube morphogenesis - activation of endothelial tube morphogenesis + + + Any process that modulates the levels of body fluids. biological_process - GO:1905956 - positive regulation of endothelial tube morphogenesis + GO:0050878 + + regulation of body fluid levels - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis. - GOC:BHF - GOC:BHF_miRNA - GOC:TermGenie - GOC:rph - GO_REF:0000058 - PMID:25961718 - - - - - up regulation of endothelial tube morphogenesis - GOC:TermGenie + Any process that modulates the levels of body fluids. + GOC:ai + GOC:dph + GOC:tb + + + + + + + + The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. + endocrine physiological process + endocrine physiology + biological_process + GO:0050886 + + + endocrine process + - - - up-regulation of endothelial tube morphogenesis - GOC:TermGenie + + + The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. + ISBN:0721662544 + + + + + + + + The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. + Wikipedia:Cognition + biological_process + GO:0050890 + + cognition + - - - upregulation of endothelial tube morphogenesis - GOC:TermGenie + + + The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. + ISBN:0721619908 + + + + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. + GO:0051869 + physiological response to stimulus + biological_process + GO:0050896 + + + + + + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + response to stimulus + - - - activation of endothelial tube morphogenesis - GOC:TermGenie + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. + GOC:ai + GOC:bf - + - + - + - - + + - + - - + + - Any apoptotic process in a retinal cell. - pr - 2012-12-12T10:15:08Z - GO:0046674 + The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal. + Wikipedia:Transduction_(physiology) + sensory detection of stimulus + sensory perception, sensory transduction of stimulus + sensory perception, stimulus detection + sensory transduction biological_process - induction of retinal programmed cell death - GO:1990009 - retinal cell apoptotic process + GO:0050906 + detection of stimulus involved in sensory perception - + - Any apoptotic process in a retinal cell. - GOC:mtg_apoptosis - PMID:15558487 - PMID:24664675 + The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos + GOC:dph - + - + - + - - + + - + + - - + + - Any apoptotic process in a compound eye retinal cell. - pr - 2012-12-12T10:21:07Z + The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. + sensory detection of light during visual perception + sensory detection of light stimulus during visual perception + sensory transduction of light during visual perception + sensory transduction of light stimulus during visual perception + visual perception, detection of light stimulus + visual perception, sensory transduction during perception of light + visual perception, sensory transduction of light stimulus biological_process - GO:1990010 - compound eye retinal cell apoptotic process + GO:0050908 + detection of light stimulus involved in visual perception - + - Any apoptotic process in a compound eye retinal cell. - GOC:mtg_apoptosis - PMID:12021768 + The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. - - hjd - 2013-09-04T21:08:14Z - exosomal secretory pathway - extracellular vesicular exosome secretion - multi-vesicular body fusion with plasma membrane - secretion of exosome - exosomal protein secretion + + + The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. biological_process - GO:1990182 - exosomal secretion + GO:0050952 + sensory perception of electrical stimulus - + - The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. - GOC:hjd - PMID:10572093 - PMID:12154376 - PMID:16773132 - PMID:18617898 - - - - - exosomal secretory pathway - PMID:18617898 + The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + + + + + + + + The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + biological_process + GO:0050953 + sensory perception of light stimulus + - - - extracellular vesicular exosome secretion - GOC:hjd + + + The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + + + + + + + + The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + mechanosensory perception + perception of mechanical stimulus + biological_process + chemi-mechanical coupling + GO:0050954 + sensory perception of mechanical stimulus + - - - secretion of exosome - PMID:18617898 + + + The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + + + + + + + + The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location. + Wikipedia:Electroreception + electroception sense + electroceptive sense + biological_process + GO:0050956 + electroception + - - - exosomal protein secretion - PMID:18617898 + + + The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location. + GOC:ai + PMID:10210663 + Wikipedia:Electroreception - + - + - + - - + + - + + - - + + - A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). - bhm - 2013-11-12T13:20:12Z - cellular_component - GO:1990234 - transferase complex + + + + + + + The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. + sensory detection of light stimulus + sensory detection of light stimulus during sensory perception + sensory perception, sensory detection of light stimulus + sensory perception, sensory transduction of light stimulus + sensory transduction of light stimulus + sensory transduction of light stimulus during sensory perception + biological_process + GO:0050962 + detection of light stimulus involved in sensory perception - + - A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). - GOC:bhm - PMID:16540464 + The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. + GOC:ai + GOC:dos - + - + - + - - + + - + + - - + + - A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin. - mah - 2014-01-30T15:55:34Z - RNA localisation to chromatin + + + + + + + The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception. + sensory detection of electrical stimulus + sensory detection of electrical stimulus during sensory perception + sensory perception, sensory detection of electrical stimulus + sensory perception, sensory transduction of electrical stimulus + sensory transduction of electrical stimulus + sensory transduction of electrical stimulus during sensory perception biological_process - GO:1990280 - RNA localization to chromatin + GO:0050963 + detection of electrical stimulus involved in sensory perception - + - A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin. - GOC:dos - GOC:mah - PMID:22582262 + The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception. + GOC:ai + GOC:dos - + - + - + - - + + - + - - + + - A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. - bhm - 2014-03-26T14:23:27Z - cellular_component - GO:1990351 - An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay). - transporter complex + The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal. + electroception, detection of electrical stimulus + electroception, sensory detection of electrical stimulus + electroception, sensory transduction + electroception, sensory transduction of electrical stimulus + biological_process + detection of electrical stimulus during electroreception + sensory detection of electrical stimulus during electroception + sensory transduction of electrical stimulus during electroception + GO:0050964 + detection of electrical stimulus involved in electroception - + - A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. - GOC:bhm - PMID:15449578 + The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos + + + + + detection of electrical stimulus during electroreception + GOC:dph + GOC:tb - + - + - + - - + + - + + - - + + - Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis. - kmv - 2014-09-30T20:35:11Z - dense core vesicle maturation + The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal. + perception of pain, detection of electrical stimulus + perception of pain, sensory detection of electrical stimulus + perception of pain, sensory transduction of electrical stimulus + biological_process + detection of electrical stimulus during sensory perception of pain + sensory detection of electrical stimulus during perception of pain + sensory transduction of electrical stimulus during perception of pain + GO:0050967 + detection of electrical stimulus involved in sensory perception of pain + + + + + The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos + GOC:dph + GOC:tb + + + + + detection of electrical stimulus during sensory perception of pain + GOC:dph + GOC:tb + + + + + + + + + The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). + Wikipedia:Touch + perception of touch + tactile sense + taction + tactition + biological_process + GO:0050975 + sensory perception of touch + + + + + The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). + GOC:ai + + + + + + + + + + The series of events by which an electrical stimulus is received and converted into a molecular signal. biological_process - GO:1990502 - dense core granule maturation + GO:0050981 + detection of electrical stimulus - + - Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis. - GOC:kmv - PMID:22654674 + The series of events by which an electrical stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos - + - + - + - - + + - + - - + + - The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. - 2015-03-16T23:23:50Z - hepatoblast proliferation + Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. biological_process - GO:1990705 - cholangiocyte proliferation + GO:0051046 + regulation of secretion - + - The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. - PMID:24434010 + Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + GOC:ai - + - + - + - - + + - - - - - - - - + + - - + + - Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. - vw - 2015-05-18T16:17:46Z + Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + up regulation of secretion + up-regulation of secretion + upregulation of secretion + activation of secretion + stimulation of secretion biological_process - GO:1990748 - cellular detoxification + GO:0051047 + positive regulation of secretion - + - Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. - GOC:vw + Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + GOC:ai - + - + - + - - + + - - - - - - - - - - - - - - - - - - - + + - - + + - A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum. - sl - 2015-06-10T18:29:21Z + Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + down regulation of secretion + down-regulation of secretion + downregulation of secretion + inhibition of secretion biological_process - GO:1990765 - colon smooth muscle contraction + GO:0051048 + negative regulation of secretion - + - A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum. - PMID:24170253 + Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + GOC:ai - + - + - + - - + + - + - - + + - The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products. - sl - 2015-06-10T20:11:09Z - stomach mucosal blood circulation + Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. biological_process - GO:1990768 - gastric mucosal blood circulation + GO:0051049 + + regulation of transport - + - The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products. - PMID:10807413 + Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai - + - + - + - - + + - - - - - - - - - - - - - - - - - - - + + - - + + - A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine. - sl - 2015-06-11T18:02:33Z + Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + up regulation of transport + up-regulation of transport + upregulation of transport + activation of transport + stimulation of transport biological_process - GO:1990770 - small intestine smooth muscle contraction + GO:0051050 + positive regulation of transport - + - A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine. - PMID:11991626 + Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai - + - + - + - - + + - + + - - + + - A process in which a protein is transported to, or maintained in, the cell periphery. - 2015-06-18T22:37:39Z + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + down regulation of transport + down-regulation of transport + downregulation of transport + inhibition of transport biological_process - GO:1990778 - protein localization to cell periphery + GO:0051051 + negative regulation of transport - + - A process in which a protein is transported to, or maintained in, the cell periphery. - PMID:18216290 + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai - + - + - + - - + + - + + + - - + + - Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell. - https://github.com/geneontology/go-ontology/issues/22182 - mcc - 2015-09-10T08:16:02Z - maintenance of vacuolar localization - maintenance of vacuole localization - maintenance of vacuole location - maintenance of vacuolar location + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + down regulation of lipid biosynthetic process + down-regulation of lipid biosynthetic process + downregulation of lipid biosynthetic process + negative regulation of lipid anabolism + negative regulation of lipid biosynthesis + negative regulation of lipid formation + negative regulation of lipid synthesis + negative regulation of lipogenesis + inhibition of lipid biosynthetic process biological_process - GO:1990849 - vacuolar localization + GO:0051055 + negative regulation of lipid biosynthetic process - + - Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell. - PMID:26283797 + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + GOC:ai + + + + + negative regulation of lipogenesis + GOC:sl - + - + - + - - + + - + + - - + + - The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus). - sl - 2015-09-25T14:26:09Z - acinic cell proliferation - acinous cell proliferation + Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + down regulation of developmental process + down-regulation of developmental process + downregulation of developmental process + inhibition of developmental process biological_process - GO:1990863 - acinar cell proliferation + GO:0051093 + negative regulation of developmental process - + - The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus). - PMID:9788538 + Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + GOC:ai - + - + - + - - + + - + + - - + + - The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. - sl - 2015-09-29T16:34:59Z - VSMC proliferation - vascular smooth muscle cell proliferation + Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + up regulation of developmental process + up-regulation of developmental process + upregulation of developmental process + activation of developmental process + stimulation of developmental process biological_process - GO:1990874 - vascular associated smooth muscle cell proliferation + GO:0051094 + positive regulation of developmental process - + - The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. - PMID:23246467 + Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + GOC:ai - + - - + + + Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. + jl + 2013-12-18T13:51:04Z + GO:1902578 + establishment and maintenance of localization + establishment and maintenance of position + localisation + establishment and maintenance of cellular component location + establishment and maintenance of substance location + establishment and maintenance of substrate location + biological_process + single organism localization + single-organism localization + GO:0051179 + + localization + + + + + Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. + GOC:ai + GOC:dos + + + + + localisation + GOC:mah + + + + + single organism localization + GOC:TermGenie + + + + + + + + - - + + - - + + - A macromolecular complex that contains both RNA and protein molecules. - pr - 2015-11-19T12:26:37Z - GO:0030529 - GO:1990903 - Wikipedia:Ribonucleoprotein - RNA-protein complex - RNP - protein-RNA complex - extracellular ribonucleoprotein complex - intracellular ribonucleoprotein complex - cellular_component - GO:1990904 - - ribonucleoprotein complex + The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + Wikipedia:Chondrogenesis + cartilage biogenesis + cartilage biosynthesis + cartilage element development + cartilage formation + cartilage organ development + chondrogenesis + biological_process + GO:0051216 + cartilage development - + - A macromolecular complex that contains both RNA and protein molecules. - GOC:krc - GOC:vesicles + The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:cjm + PMID:23251424 - + - + - + - - + + - - - - - - - - - - - - - - - - - + + + - - - - - - + + - - - - - - - The cytoplasm of an ovum. - - sl - 2015-12-10T21:40:16Z - cellular_component - GO:1990917 - ooplasm + Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + up regulation of protein transport + up-regulation of protein transport + upregulation of protein transport + activation of protein transport + stimulation of protein transport + biological_process + GO:0051222 + positive regulation of protein transport - + - The cytoplasm of an ovum. - PMID:19022436 + Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai - + - + - + - - + + - + - Any process that modulates the frequency, rate or extent of multicellular organismal development. - tb - 2010-08-05T11:25:59Z + Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. biological_process - GO:2000026 - regulation of multicellular organismal development + GO:0051223 + regulation of protein transport - + - Any process that modulates the frequency, rate or extent of multicellular organismal development. - GOC:obol + Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai - + - + - - + + - + + + - - + + - Any process that modulates the frequency, rate or extent of animal organ morphogenesis. - tb - 2010-08-05T11:26:27Z + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + down regulation of protein transport + down-regulation of protein transport + downregulation of protein transport + inhibition of protein transport biological_process - regulation of histogenesis and organogenesis - GO:2000027 - regulation of animal organ morphogenesis + GO:0051224 + negative regulation of protein transport - + - Any process that modulates the frequency, rate or extent of animal organ morphogenesis. - GOC:obol + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + + + + + + + + + Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. + establishment of localisation + biological_process + GO:0051234 + + + + + establishment of localization + + + + + Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. + GOC:ai + GOC:dos - - - regulation of histogenesis and organogenesis - GOC:obol + + + establishment of localisation + GOC:mah - + - + - + - + - + - Any process that modulates the frequency, rate or extent of stem cell division. - tb - 2010-08-05T11:34:53Z - regulation of stem cell renewal + Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. biological_process - GO:2000035 - regulation of stem cell division + GO:0051239 + regulation of multicellular organismal process - + - Any process that modulates the frequency, rate or extent of stem cell division. - GOC:obol - - - - - regulation of stem cell renewal - GOC:obol + Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. + GOC:ai + GOC:dph + GOC:tb - + - + - - + + - + + - - + + - Any process that modulates the frequency, rate or extent of pancreatic B cell development. - tb - 2010-08-27T11:19:37Z - regulation of pancreatic B cell development - regulation of pancreatic beta cell development + Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. + up regulation of multicellular organismal process + up-regulation of multicellular organismal process + upregulation of multicellular organismal process + activation of multicellular organismal process + stimulation of multicellular organismal process biological_process - GO:2000074 - regulation of type B pancreatic cell development + GO:0051240 + positive regulation of multicellular organismal process - + - Any process that modulates the frequency, rate or extent of pancreatic B cell development. - GOC:obol - GOC:yaf - - - - - regulation of pancreatic B cell development - GOC:mah - - - - - regulation of pancreatic beta cell development - GOC:obol + Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. + GOC:ai - + - + - + - - - - - - - - - + + - Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development. - tb - 2010-08-27T11:21:17Z - negative regulation of pancreatic B cell development - negative regulation of pancreatic beta cell development + Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. + down regulation of multicellular organismal process + down-regulation of multicellular organismal process + downregulation of multicellular organismal process + inhibition of multicellular organismal process biological_process - GO:2000077 - negative regulation of type B pancreatic cell development + GO:0051241 + negative regulation of multicellular organismal process - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development. - GOC:obol - GOC:yaf - - - - - negative regulation of pancreatic B cell development - GOC:mah + Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. + GOC:ai + + + + + + + + The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. + Wikipedia:Cell_division + biological_process + GO:0051301 + + + + Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. + cell division + - - - negative regulation of pancreatic beta cell development - GOC:obol + + + The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. + GOC:di + GOC:go_curators + GOC:pr - + - + - - + + - - - - - - - - - - - - - - - - + - - + + - Any process that activates or increases the frequency, rate or extent of pancreatic B cell development. - tb - 2010-08-27T11:21:19Z - positive regulation of pancreatic B cell development - positive regulation of pancreatic beta cell development + Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. biological_process - GO:2000078 - positive regulation of type B pancreatic cell development + GO:0051302 + regulation of cell division - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 + + + Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. + GOC:go_curators + + + + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. + biological_process + response to electricity + GO:0051602 + response to electrical stimulus + - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. + GOC:ai + + + + + + + + + The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. + stimulus detection + biological_process + perception of stimulus + stimulus sensing + GO:0051606 + + detection of stimulus + + + + + The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. + GOC:add + GOC:ai + GOC:dph + GOC:mah + + + + + + + + + A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane. + jl + 2013-12-18T14:04:32Z + GO:1902580 + cellular localisation + establishment and maintenance of cellular localization + establishment and maintenance of localization in cell or cell membrane + single organism cellular localization + intracellular localization + localization within cell + biological_process + single-organism cellular localization + GO:0051641 + + cellular localization + - + - Any process that activates or increases the frequency, rate or extent of pancreatic B cell development. - GOC:obol - GOC:yaf + A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane. + GOC:tb + GOC:vw - + - positive regulation of pancreatic B cell development - GOC:mah + cellular localisation + GOC:mah - + - positive regulation of pancreatic beta cell development - GOC:obol + single organism cellular localization + GOC:TermGenie + + + + + + + + + + localization of cell + + + + + + + + + A biological process which involves another organism of the same or different species. + GO:0051706 + interaction between organisms + physiological interaction between organisms + physiological interaction with other organism + biological_process + GO:0051704 + + + multi-organism process + + + + + A biological process which involves another organism of the same or different species. + GOC:jl + + + + + + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. + biological_process + GO:0051716 + + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + cellular response to stimulus + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. + GOC:bf + GOC:jl - + - + - - + + - + + - - + + - Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. - mah - 2010-09-15T01:42:05Z - regulation of leukocyte apoptosis + Any process that activates or increases the frequency, rate or extent of cell division. + up regulation of cell division + up-regulation of cell division + upregulation of cell division + activation of cell division + stimulation of cell division biological_process - GO:2000106 - regulation of leukocyte apoptotic process + GO:0051781 + positive regulation of cell division - + - Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. - GOC:BHF - GOC:mtg_apoptosis + Any process that activates or increases the frequency, rate or extent of cell division. + GOC:ai - + - + - + - - + + - + - Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. - mah - 2010-09-15T01:42:09Z - negative regulation of leukocyte apoptosis + Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. + down regulation of cell division + down-regulation of cell division + downregulation of cell division + inhibition of cell division biological_process - GO:2000107 - negative regulation of leukocyte apoptotic process + GO:0051782 + negative regulation of cell division - + - Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. - GOC:BHF - GOC:mtg_apoptosis + Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. + GOC:ai - + - + - - + + - - + - - + + - Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. - mah - 2010-09-15T01:42:12Z - positive regulation of leukocyte apoptosis + Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. biological_process - GO:2000108 - positive regulation of leukocyte apoptotic process + GO:0051930 + regulation of sensory perception of pain - + - Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. - GOC:BHF - GOC:mtg_apoptosis + Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. + GOC:ai - + - + - + - + - + - Any process that modulates the frequency, rate or extent of establishment of cell polarity. - dph - 2010-09-16T01:22:36Z - regulation of cell polarization + Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. biological_process - regulation of bud site selection/establishment of cell polarity - GO:2000114 - regulation of establishment of cell polarity + GO:0051931 + regulation of sensory perception - + - Any process that modulates the frequency, rate or extent of establishment of cell polarity. - GOC:dph - - - - - regulation of cell polarization - GOC:obol + Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. + GOC:ai + + + + + + + + + The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + biological_process + GO:0051937 + catecholamine transport + - - - regulation of bud site selection/establishment of cell polarity - GOC:obol + + + The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + GOC:ai + ISBN:0198506732 - + - + - + - + - + - Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis. - dph - 2010-09-29T12:43:53Z + Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. biological_process - GO:2000136 - regulation of cell proliferation involved in heart morphogenesis + GO:0051952 + regulation of amine transport - + - Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis. - GOC:dph + Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai - + - + - + - - + + - + - Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis. - dph - 2010-09-29T12:43:55Z + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + down regulation of amine transport + down-regulation of amine transport + downregulation of amine transport + inhibition of amine transport biological_process - GO:2000137 - negative regulation of cell proliferation involved in heart morphogenesis + GO:0051953 + negative regulation of amine transport - + - Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis. - GOC:dph + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai - + - + - + - - + + - + - Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis. - dph - 2010-09-29T12:43:57Z + Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + up regulation of amine transport + up-regulation of amine transport + upregulation of amine transport + activation of amine transport + stimulation of amine transport biological_process - GO:2000138 - positive regulation of cell proliferation involved in heart morphogenesis + GO:0051954 + positive regulation of amine transport - + - Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis. - GOC:dph + Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai - + - + - + - - + - + - Any process that modulates the frequency, rate or extent of cell motility. - mah - 2010-10-01T09:41:21Z - regulation of cell locomotion - regulation of movement of a cell + Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. biological_process - regulation of cell movement - GO:2000145 - regulation of cell motility + GO:0051960 + regulation of nervous system development - + - Any process that modulates the frequency, rate or extent of cell motility. - GOC:mah - - - - - regulation of cell locomotion - GOC:obol - - - - - regulation of movement of a cell - GOC:obol - - - - - regulation of cell movement - GOC:obol + Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + GOC:ai - + - + - + - - - + + + - + - Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. - mah - 2010-10-01T09:41:26Z - negative regulation of cell locomotion - negative regulation of movement of a cell + Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + down regulation of nervous system development + down-regulation of nervous system development + downregulation of nervous system development + inhibition of nervous system development biological_process - negative regulation of cell movement - GO:2000146 - negative regulation of cell motility + GO:0051961 + negative regulation of nervous system development - + - Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. - GOC:mah - - - - - negative regulation of cell locomotion - GOC:obol - - - - - negative regulation of movement of a cell - GOC:obol - - - - - negative regulation of cell movement - GOC:obol + Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + GOC:ai - + - + - + - - - + + + - + - Any process that activates or increases the frequency, rate or extent of cell motility. - mah - 2010-10-01T09:41:30Z - positive regulation of cell locomotion - positive regulation of movement of a cell + Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + up regulation of nervous system development + up-regulation of nervous system development + upregulation of nervous system development + activation of nervous system development + stimulation of nervous system development biological_process - positive regulation of cell movement - GO:2000147 - positive regulation of cell motility + GO:0051962 + positive regulation of nervous system development - + - Any process that activates or increases the frequency, rate or extent of cell motility. - GOC:mah - - - - - positive regulation of cell locomotion - GOC:obol - - - - - positive regulation of movement of a cell - GOC:obol - - - - - positive regulation of cell movement - GOC:obol + Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + GOC:ai - + - - - - - - - - - - - - - + + - - + + - Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve. - rl - 2010-10-07T12:07:54Z + The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body. + heart beating biological_process - GO:2000172 - regulation of branching morphogenesis of a nerve + cardiac contraction + hemolymph circulation + GO:0060047 + heart contraction - + - Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve. - GOC:BHF + The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body. + GOC:dph - + - + - - + + - - - + - - + + - Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve. - rl - 2010-10-07T12:07:56Z + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. biological_process - GO:2000173 - negative regulation of branching morphogenesis of a nerve + GO:0060255 + regulation of macromolecule metabolic process - + - Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve. - GOC:BHF + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb - + - + - + - + + - + - Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. - dph - 2010-10-13T12:40:41Z + Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. + regulation of cellular localisation biological_process - GO:2000177 - regulation of neural precursor cell proliferation + GO:0060341 + regulation of cellular localization - + - Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. - GOC:dph - GOC:yaf + Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. + GOC:dph + GOC:tb + + + + + regulation of cellular localisation + GOC:mah + + + + + + + + + The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. + biological_process + GO:0060429 + + epithelium development + + + + + The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. + GOC:dph + GOC:mtg_lung - + - + - - + + - - + + - - + + - Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. - dph - 2010-10-13T12:40:43Z + Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. biological_process - GO:2000178 - negative regulation of neural precursor cell proliferation + GO:0060453 + regulation of gastric acid secretion - + - Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. - GOC:dph - GOC:yaf + Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + GOC:dph + GOC:tb - + - + - + - - + + + - + - Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. - dph - 2010-10-13T12:40:45Z + Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. biological_process - GO:2000179 - positive regulation of neural precursor cell proliferation + GO:0060454 + positive regulation of gastric acid secretion - + - Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. - GOC:dph - GOC:yaf + Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + GOC:dph + GOC:tb - + - + - + - - + + + - + - Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis. - dph - 2010-10-13T12:46:31Z + Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. biological_process - GO:2000181 - negative regulation of blood vessel morphogenesis + GO:0060455 + negative regulation of gastric acid secretion - + - Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis. - GOC:dph - GOC:yaf + Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + GOC:dph + GOC:tb - + - + - - + + - - + + - - + + - Any process that modulates the frequency, rate or extent of phosphate transmembrane transport. - vw - 2010-10-15T11:33:04Z - regulation of phosphate membrane transport + Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. biological_process - GO:2000185 - regulation of phosphate transmembrane transport + GO:0060456 + positive regulation of digestive system process - + - Any process that modulates the frequency, rate or extent of phosphate transmembrane transport. - GOC:obol + Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:dph + GOC:tb - + - + - + - - + + - + - Any process that stops, prevents, or reduces the frequency, rate or extent of phosphate transmembrane transport. - vw - 2010-10-15T11:33:08Z - negative regulation of phosphate membrane transport + Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. biological_process - GO:2000186 - negative regulation of phosphate transmembrane transport + GO:0060457 + negative regulation of digestive system process - + - Any process that stops, prevents, or reduces the frequency, rate or extent of phosphate transmembrane transport. - GOC:obol + Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:dph + GOC:tb - + - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport. - vw - 2010-10-15T11:33:10Z - positive regulation of phosphate membrane transport + + + + The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + dph + 2009-04-28T09:33:36Z biological_process - GO:2000187 - positive regulation of phosphate transmembrane transport + GO:0060562 + epithelial tube morphogenesis - + - Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport. - GOC:obol + The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + GOC:dph - + - + - + - - + + - + - Any process that modulates the frequency, rate or extent of female gonad development. - yaf - 2010-10-19T10:45:34Z - regulation of ovarian development - regulation of ovary development + Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. + dph + 2009-06-05T12:41:44Z biological_process - GO:2000194 - regulation of female gonad development + GO:0060688 + regulation of morphogenesis of a branching structure - + - Any process that modulates the frequency, rate or extent of female gonad development. - GOC:obol - - - - - regulation of ovarian development - GOC:obol - - - - - regulation of ovary development - GOC:obol + Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. + GOC:dph - + - - - - - - - - - - - - - - + + - - + + - Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development. - yaf - 2010-10-19T10:45:38Z - negative regulation of ovarian development - negative regulation of ovary development + The regulated release of a hormone into the circulatory system. + dph + 2010-01-11T09:03:48Z biological_process - GO:2000195 - negative regulation of female gonad development + GO:0060986 + endocrine hormone secretion - + - Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development. - GOC:obol - - - - - negative regulation of ovarian development - GOC:obol - - - - - negative regulation of ovary development - GOC:obol + The regulated release of a hormone into the circulatory system. + GOC:dph - + - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of female gonad development. - yaf - 2010-10-19T10:45:41Z - positive regulation of ovarian development - positive regulation of ovary development + + + An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. + dph + 2010-01-22T09:09:10Z + hepatobiliary system process biological_process - GO:2000196 - positive regulation of female gonad development + GO:0061007 + + hepaticobiliary system process - + - Any process that activates or increases the frequency, rate or extent of female gonad development. - GOC:obol - - - - - positive regulation of ovarian development - GOC:obol + An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. + GOC:dph - + - positive regulation of ovary development - GOC:obol + hepatobiliary system process + GOC:dph - + - + - + - + - + - Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation. - mah - 2010-11-09T03:43:37Z - regulation of pancreatic alpha cell differentiation + Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + dph + 2010-02-09T03:41:35Z biological_process - GO:2000226 - regulation of pancreatic A cell differentiation + GO:0061035 + regulation of cartilage development - + - Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation. - GOC:mah - - - - - regulation of pancreatic alpha cell differentiation - GOC:obol + Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:dph - + - + - - + + - - - - - - - - - + + + - - + + - Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation. - mah - 2010-11-09T03:43:40Z - negative regulation of pancreatic alpha cell differentiation + Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + dph + 2010-02-09T03:41:35Z biological_process - GO:2000227 - negative regulation of pancreatic A cell differentiation + GO:0061036 + positive regulation of cartilage development - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation. - GOC:mah - - - - - negative regulation of pancreatic alpha cell differentiation - GOC:obol + Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:dph - + - + - - + + - - - - - - - - - + + + - - + + - Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation. - mah - 2010-11-09T03:43:42Z - positive regulation of pancreatic alpha cell differentiation + Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + dph + 2010-02-09T03:41:35Z biological_process - GO:2000228 - positive regulation of pancreatic A cell differentiation + GO:0061037 + negative regulation of cartilage development - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation. - GOC:mah - - - - - positive regulation of pancreatic alpha cell differentiation - GOC:obol + Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:dph - + - + - + - + - + - Any process that modulates the frequency, rate or extent of reproductive process. - mah - 2010-11-10T02:44:02Z + Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. + dph + 2010-03-11T12:59:21Z biological_process - GO:2000241 - regulation of reproductive process + GO:0061062 + regulation of nematode larval development - + - Any process that modulates the frequency, rate or extent of reproductive process. - GOC:mah + Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. + GOC:dph + GOC:kmv - + - + - - + + - - + + - - + + - Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. - mah - 2010-11-10T02:44:05Z + Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. + dph + 2010-03-11T01:03:34Z biological_process - GO:2000242 - negative regulation of reproductive process + GO:0061063 + positive regulation of nematode larval development - + - Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. - GOC:mah + Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. + GOC:dph + GOC:kmv - + - + - - + + - - + + - - + + - Any process that activates or increases the frequency, rate or extent of reproductive process. - mah - 2010-11-10T02:44:08Z + Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. + dph + 2010-03-11T01:04:39Z biological_process - GO:2000243 - positive regulation of reproductive process + GO:0061064 + negative regulation of nematode larval development - + - Any process that activates or increases the frequency, rate or extent of reproductive process. - GOC:mah + Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. + GOC:dph + GOC:kmv - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity. - vw - 2010-11-11T11:40:34Z - negative regulation of establishment and/or maintenance of neuroblast cell polarity + + + + The process in which the anatomical structures of a branched epithelium are generated and organized. + dph + 2010-05-25T09:05:34Z biological_process - GO:2000248 - negative regulation of establishment or maintenance of neuroblast polarity + GO:0061138 + morphogenesis of a branching epithelium - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity. - GOC:obol - - - - - negative regulation of establishment and/or maintenance of neuroblast cell polarity - GOC:obol + The process in which the anatomical structures of a branched epithelium are generated and organized. + GOC:dph - + - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of fibroblast apoptotic process. - jl - 2010-11-23T01:07:23Z - regulation of fibroblast apoptosis + + + The progression of a connective tissue over time, from its formation to the mature structure. + dph + 2012-03-22T12:53:41Z biological_process - GO:2000269 - regulation of fibroblast apoptotic process + GO:0061448 + connective tissue development - + - Any process that modulates the frequency, rate or extent of fibroblast apoptotic process. - GOC:mtg_apoptosis - GOC:obol - GOC:yaf + The progression of a connective tissue over time, from its formation to the mature structure. + GOC:BHF - + - + - - + + - - + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process. - jl - 2010-11-23T01:07:27Z - negative regulation of fibroblast apoptosis + Any process that modulates the rate, frequency or extent of a small molecule metabolic process. + dph + 2018-03-19T14:11:54Z + regulation of small molecule metabolism biological_process - GO:2000270 - negative regulation of fibroblast apoptotic process + GO:0062012 + regulation of small molecule metabolic process - + - Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process. - GOC:mtg_apoptosis - GOC:obol - GOC:yaf + Any process that modulates the rate, frequency or extent of a small molecule metabolic process. + GOC:vw - + - + - + - - + + - + - Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process. - jl - 2010-11-23T01:07:29Z - positive regulation of fibroblast apoptosis + Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process. + dph + 2018-03-19T14:25:10Z + positive regulation of small molecule metabolism biological_process - GO:2000271 - positive regulation of fibroblast apoptotic process + GO:0062013 + positive regulation of small molecule metabolic process - + - Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process. - GOC:mtg_apoptosis - GOC:obol - GOC:yaf + Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process. + GOC:vw - + - + - - + + - - + + - - + + - Any process that modulates the frequency, rate or extent of DNA biosynthetic process. - yaf - 2010-12-08T04:48:15Z - regulation of DNA anabolism - regulation of DNA biosynthesis - regulation of DNA formation - regulation of DNA synthesis + Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process. + dph + 2018-03-19T14:27:23Z + negative regulation of small molecule metabolism biological_process - GO:2000278 - regulation of DNA biosynthetic process + GO:0062014 + negative regulation of small molecule metabolic process - + - Any process that modulates the frequency, rate or extent of DNA biosynthetic process. - GOC:obol - - - - - regulation of DNA anabolism - GOC:obol - - - - - regulation of DNA biosynthesis - GOC:obol - - - - - regulation of DNA formation - GOC:obol + Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process. + GOC:vw + + + + + + + + An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. + dph + 2018-04-13T12:47:21Z + cellular_component + GO:0062023 + collagen-containing extracellular matrix + - - - regulation of DNA synthesis - GOC:obol + + + An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. + GOC:BHF + GOC:rph + PMID:21123617 - + - + - + - - + + - - - + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. - yaf - 2010-12-08T04:48:20Z - negative regulation of DNA anabolism - negative regulation of DNA biosynthesis - negative regulation of DNA formation - negative regulation of DNA synthesis + The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal. + dph + 2019-09-13T13:48:47Z biological_process - GO:2000279 - negative regulation of DNA biosynthetic process + GO:0062149 + detection of stimulus involved in sensory perception of pain - + - Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. - GOC:obol - - - - - negative regulation of DNA anabolism - GOC:obol - - - - - negative regulation of DNA biosynthesis - GOC:obol + The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal. + PMID:19837031 + + + + + + + + Any process that modulates a measurable attribute of any biological process, quality or function. + regulation + biological_process + GO:0065007 + + + biological regulation + - - - negative regulation of DNA formation - GOC:obol + + + Any process that modulates a measurable attribute of any biological process, quality or function. + GOC:dph + GOC:isa_complete + GOC:mah + GOC:pr + GOC:vw + + + + + + + + Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. + regulation of biological attribute + regulation of biological characteristic + biological_process + GO:0065008 + + regulation of biological quality + - - - negative regulation of DNA synthesis - GOC:obol + + + Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. + GOC:dph + GOC:isa_complete + GOC:mah + GOC:pr + GOC:vw - + - + - + - - + - + - Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process. - vw - 2010-12-10T11:54:19Z - regulation of amino acid biosynthetic process - regulation of cellular amino acid anabolism - regulation of cellular amino acid biosynthesis - regulation of cellular amino acid formation - regulation of cellular amino acid synthesis + Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + regulation of a molecular function biological_process - GO:2000282 - regulation of cellular amino acid biosynthetic process + GO:0065009 + + + + regulation of molecular function - + - Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process. - GOC:obol - - - - - regulation of amino acid biosynthetic process - GOC:obol - - - - - regulation of cellular amino acid anabolism - GOC:obol - - - - - regulation of cellular amino acid biosynthesis - GOC:obol - - - - - regulation of cellular amino acid formation - GOC:obol - - - - - regulation of cellular amino acid synthesis - GOC:obol + Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + GOC:isa_complete - + - + - + - - + + - - - + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of an amino acid biosynthetic process. - vw - 2010-12-10T11:54:23Z - negative regulation of amino acid anabolism - negative regulation of amino acid biosynthesis - negative regulation of amino acid formation - negative regulation of amino acid synthesis - negative regulation of cellular amino acid biosynthetic process - biological_process - GO:2000283 - negative regulation of amino acid biosynthetic process + Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. + extracellular membrane-enclosed organelle + cellular_component + GO:0065010 + extracellular membrane-bounded organelle - + - Any process that stops, prevents or reduces the frequency, rate or extent of an amino acid biosynthetic process. - GOC:obol - - - - - negative regulation of amino acid anabolism - GOC:obol - - - - - negative regulation of amino acid biosynthesis - GOC:obol - - - - - negative regulation of amino acid formation - GOC:obol - - - - - negative regulation of amino acid synthesis - GOC:obol + Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. + GOC:isa_complete + + + + + + + + The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans). + biological_process + GO:0070091 + glucagon secretion + - - - negative regulation of cellular amino acid biosynthetic process - GOC:obol + + + The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans). + GOC:BHF + GOC:rl - + - + - - + + - - - + - - + + - Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process. - vw - 2010-12-10T11:54:27Z - positive regulation of amino acid anabolism - positive regulation of amino acid biosynthesis - positive regulation of amino acid formation - positive regulation of amino acid synthesis - positive regulation of cellular amino acid biosynthetic process + Any process that modulates the frequency, rate or extent of the regulated release of glucagon. biological_process - GO:2000284 - positive regulation of amino acid biosynthetic process + GO:0070092 + regulation of glucagon secretion - + - Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process. - GOC:obol - - - - - positive regulation of amino acid anabolism - GOC:obol - - - - - positive regulation of amino acid biosynthesis - GOC:obol - - - - - positive regulation of amino acid formation - GOC:obol - - - - - positive regulation of amino acid synthesis - GOC:obol - - - - - positive regulation of cellular amino acid biosynthetic process - GOC:obol + Any process that modulates the frequency, rate or extent of the regulated release of glucagon. + GOC:BHF + GOC:mah - + - + - - + + - - + + - - + + - Any process that activates or increases the frequency, rate or extent of myotome development. - rl - 2010-12-16T05:17:15Z + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon. + down regulation of glucagon secretion + down-regulation of glucagon secretion + downregulation of glucagon secretion + inhibition of glucagon secretion biological_process - GO:2000287 - positive regulation of myotome development + GO:0070093 + negative regulation of glucagon secretion - + - Any process that activates or increases the frequency, rate or extent of myotome development. - GOC:BHF + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon. + GOC:BHF + GOC:mah - + - + - + - - + + - + - Any process that activates or increases the frequency, rate or extent of myoblast proliferation. - rl - 2010-12-16T05:20:52Z + Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon. + up regulation of glucagon secretion + up-regulation of glucagon secretion + upregulation of glucagon secretion + activation of glucagon secretion + stimulation of glucagon secretion biological_process - GO:2000288 - positive regulation of myoblast proliferation + GO:0070094 + positive regulation of glucagon secretion + + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon. + GOC:BHF + GOC:mah + + + + + + + + + A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. + anchoring cell junction + cellular_component + GO:0070161 + anchoring junction - + - Any process that activates or increases the frequency, rate or extent of myoblast proliferation. - GOC:BHF + A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. + ISBN:0815332181 + + + + + anchoring cell junction + GOC:mah - + - + - + - + - + - Any process that modulates the frequency, rate or extent of myotome development. - mah - 2010-12-20T10:22:05Z + Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. + regulation of establishment of protein localisation + biological_process + GO:0070201 + regulation of establishment of protein localization + + + + + Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. + GOC:BHF + GOC:mah + + + + + regulation of establishment of protein localisation + GOC:mah + + + + + + + + + The regulated release of somatostatin from secretory granules in the D cells of the pancreas. biological_process - GO:2000290 - regulation of myotome development + GO:0070253 + somatostatin secretion - + - Any process that modulates the frequency, rate or extent of myotome development. - GOC:mah + The regulated release of somatostatin from secretory granules in the D cells of the pancreas. + GOC:mah - + - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of myoblast proliferation. - mah - 2010-12-20T10:34:26Z + + + + The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. + mucus production biological_process - GO:2000291 - regulation of myoblast proliferation + GO:0070254 + mucus secretion - + - Any process that modulates the frequency, rate or extent of myoblast proliferation. - GOC:mah + The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. + GOC:add + ISBN:068340007X + ISBN:0721662544 + + + + + mucus production + GOC:add - + - + - + - - + + + - + - Any process that modulates the frequency, rate or extent of defecation. - bf - 2010-12-21T09:23:08Z + Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + regulation of mucus production biological_process - GO:2000292 - regulation of defecation + GO:0070255 + regulation of mucus secretion - + - Any process that modulates the frequency, rate or extent of defecation. - GOC:obol + Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + GOC:add + + + + + regulation of mucus production + GOC:add - + - + - + - - + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of defecation. - bf - 2010-12-21T09:23:13Z + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + negative regulation of mucus production biological_process - GO:2000293 - negative regulation of defecation + GO:0070256 + negative regulation of mucus secretion - + - Any process that stops, prevents or reduces the frequency, rate or extent of defecation. - GOC:obol + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + GOC:add + + + + + negative regulation of mucus production + GOC:add - + - + - + - - + + - + - Any process that activates or increases the frequency, rate or extent of defecation. - bf - 2010-12-21T09:23:16Z + Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + positive regulation of mucus production biological_process - GO:2000294 - positive regulation of defecation + GO:0070257 + positive regulation of mucus secretion - + - Any process that activates or increases the frequency, rate or extent of defecation. - GOC:obol + Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + GOC:add + + + + + positive regulation of mucus production + GOC:add + + + + + + + + + + Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. + mah + 2009-06-16T04:08:29Z + cellular macromolecule localisation + biological_process + GO:0070727 + cellular macromolecule localization + + + + + Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. + GOC:mah + + + + + cellular macromolecule localisation + GOC:mah - + - + - + - + + + + - + - Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process. + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. mah - 2011-02-03T10:43:16Z - regulation of apoptosis of endothelial cells - regulation of endothelial cell programmed cell death by apoptosis - regulation of killing of endothelial cells - regulation of programmed cell death of endothelial cells by apoptosis - regulation of programmed cell death, endothelial cells - regulation of endothelial cell apoptosis + 2009-08-14T03:09:02Z + regulation of bile acid anabolism + regulation of bile acid biosynthesis + regulation of bile acid formation + regulation of bile acid synthesis biological_process - GO:2000351 - regulation of endothelial cell apoptotic process + GO:0070857 + regulation of bile acid biosynthetic process - + - Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process. - GOC:mah - GOC:mtg_apoptosis - - - - - regulation of apoptosis of endothelial cells - GOC:obol + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + GOC:BHF + GOC:mah - + - regulation of endothelial cell programmed cell death by apoptosis - GOC:obol + regulation of bile acid anabolism + GOC:mah - + - regulation of killing of endothelial cells - GOC:obol + regulation of bile acid biosynthesis + GOC:mah - + - regulation of programmed cell death of endothelial cells by apoptosis - GOC:obol + regulation of bile acid formation + GOC:mah - + - regulation of programmed cell death, endothelial cells - GOC:obol + regulation of bile acid synthesis + GOC:mah - + - + - + - - + + + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. mah - 2011-02-03T10:43:20Z - negative regulation of apoptosis of endothelial cells - negative regulation of endothelial cell programmed cell death by apoptosis - negative regulation of killing of endothelial cells - negative regulation of programmed cell death of endothelial cells by apoptosis - negative regulation of programmed cell death, endothelial cells - negative regulation of endothelial cell apoptosis + 2009-08-14T03:16:40Z + down regulation of bile acid biosynthetic process + down-regulation of bile acid biosynthetic process + downregulation of bile acid biosynthetic process + negative regulation of bile acid anabolism + negative regulation of bile acid biosynthesis + negative regulation of bile acid formation + negative regulation of bile acid synthesis + inhibition of bile acid biosynthetic process biological_process - GO:2000352 - negative regulation of endothelial cell apoptotic process + GO:0070858 + negative regulation of bile acid biosynthetic process - + - Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. - GOC:BHF - GOC:mah - GOC:mtg_apoptosis + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + GOC:BHF + GOC:mah - + - negative regulation of apoptosis of endothelial cells - GOC:obol + down regulation of bile acid biosynthetic process + GOC:mah - + - negative regulation of endothelial cell programmed cell death by apoptosis - GOC:obol + down-regulation of bile acid biosynthetic process + GOC:mah - + - negative regulation of killing of endothelial cells - GOC:obol + downregulation of bile acid biosynthetic process + GOC:mah - + - negative regulation of programmed cell death of endothelial cells by apoptosis - GOC:obol + negative regulation of bile acid anabolism + GOC:mah - + - negative regulation of programmed cell death, endothelial cells - GOC:obol + negative regulation of bile acid biosynthesis + GOC:mah + + + + + negative regulation of bile acid formation + GOC:mah + + + + + negative regulation of bile acid synthesis + GOC:mah + + + + + inhibition of bile acid biosynthetic process + GOC:mah - + - + - + - - + + + + - + - Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. mah - 2011-02-03T10:43:23Z - positive regulation of apoptosis of endothelial cells - positive regulation of endothelial cell programmed cell death by apoptosis - positive regulation of killing of endothelial cells - positive regulation of programmed cell death of endothelial cells by apoptosis - positive regulation of programmed cell death, endothelial cells - positive regulation of endothelial cell apoptosis + 2009-08-14T03:22:58Z + positive regulation of bile acid anabolism + positive regulation of bile acid biosynthesis + positive regulation of bile acid formation + positive regulation of bile acid synthesis + up regulation of bile acid biosynthetic process + up-regulation of bile acid biosynthetic process + upregulation of bile acid biosynthetic process + activation of bile acid biosynthetic process + stimulation of bile acid biosynthetic process biological_process - GO:2000353 - positive regulation of endothelial cell apoptotic process + GO:0070859 + positive regulation of bile acid biosynthetic process - + - Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. - GOC:BHF - GOC:mah - GOC:mtg_apoptosis + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + GOC:BHF + GOC:mah - + - positive regulation of apoptosis of endothelial cells - GOC:obol + positive regulation of bile acid anabolism + GOC:mah + + + + + positive regulation of bile acid biosynthesis + GOC:mah - + - positive regulation of endothelial cell programmed cell death by apoptosis - GOC:obol + positive regulation of bile acid formation + GOC:mah - + - positive regulation of killing of endothelial cells - GOC:obol + positive regulation of bile acid synthesis + GOC:mah - + - positive regulation of programmed cell death of endothelial cells by apoptosis - GOC:obol + up regulation of bile acid biosynthetic process + GOC:mah - + - positive regulation of programmed cell death, endothelial cells - GOC:obol + up-regulation of bile acid biosynthetic process + GOC:mah + + + + + upregulation of bile acid biosynthetic process + GOC:mah + + + + + activation of bile acid biosynthetic process + GOC:mah + + + + + stimulation of bile acid biosynthetic process + GOC:mah - + - + - + - + + + - + - Any process that modulates the frequency, rate or extent of oxygen metabolic process. + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. mah - 2011-02-11T02:03:32Z - regulation of diatomic oxygen metabolic process - regulation of oxygen metabolism + 2009-08-20T02:44:53Z + regulation of glycogen metabolism biological_process - GO:2000374 - regulation of oxygen metabolic process + GO:0070873 + regulation of glycogen metabolic process - + - Any process that modulates the frequency, rate or extent of oxygen metabolic process. - GOC:mah - - - - - regulation of diatomic oxygen metabolic process - GOC:obol + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + GOC:mah - + - regulation of oxygen metabolism - GOC:obol + regulation of glycogen metabolism + GOC:mah - + - + - + - - + + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process. + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen. mah - 2011-02-11T02:03:44Z - negative regulation of diatomic oxygen metabolic process - negative regulation of oxygen metabolism + 2009-08-20T02:50:41Z + negative regulation of glycogen metabolism biological_process - GO:2000375 - negative regulation of oxygen metabolic process + GO:0070874 + negative regulation of glycogen metabolic process - + - Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process. - GOC:mah - - - - - negative regulation of diatomic oxygen metabolic process - GOC:obol + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + GOC:mah - + - negative regulation of oxygen metabolism - GOC:obol + negative regulation of glycogen metabolism + GOC:mah - + - + - + - - + + + - + - Any process that activates or increases the frequency, rate or extent of oxygen metabolic process. + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. mah - 2011-02-11T02:03:52Z - positive regulation of diatomic oxygen metabolic process - positive regulation of oxygen metabolism + 2009-08-20T02:53:55Z + positive regulation of glycogen metabolism biological_process - GO:2000376 - positive regulation of oxygen metabolic process + GO:0070875 + positive regulation of glycogen metabolic process - + - Any process that activates or increases the frequency, rate or extent of oxygen metabolic process. - GOC:mah + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + GOC:mah - + - positive regulation of diatomic oxygen metabolic process - GOC:obol + positive regulation of glycogen metabolism + GOC:mah + + + + + + + + + The process of biting and mashing food with the teeth prior to swallowing. + mah + 2010-02-10T11:19:48Z + chewing + biological_process + GO:0071626 + mastication + + + + + The process of biting and mashing food with the teeth prior to swallowing. + GOC:gvg - + - positive regulation of oxygen metabolism - GOC:obol + chewing + GOC:mah - + - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of mesoderm development. - vk - 2011-02-15T03:09:46Z + + + Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location. + mah + 2010-02-25T04:00:13Z + protein localisation in extracellular region + protein localization in extracellular region biological_process - GO:2000380 - regulation of mesoderm development + GO:0071692 + protein localization to extracellular region - + - Any process that modulates the frequency, rate or extent of mesoderm development. - GOC:BHF + Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location. + GOC:mah + + + + + protein localisation in extracellular region + GOC:mah - + - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development. - vk - 2011-02-15T03:10:02Z + + + The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. + mah + 2010-03-08T02:15:14Z biological_process - GO:2000381 - negative regulation of mesoderm development + GO:0071702 + organic substance transport - + - Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development. - GOC:BHF + The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. + GOC:mah - + - - - - - - - - - - - - - - + + + The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. + mah + 2010-03-08T03:32:18Z + organic molecular entity metabolic process + organic molecular entity metabolism + organic substance metabolism + biological_process + GO:0071704 + organic substance metabolic process + + + + + The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. + GOC:mah + + + + + + + + + The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + mah + 2010-03-08T03:56:28Z + biological_process + GO:0071705 + nitrogen compound transport + + + + + The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + + + + + + + + + The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. + mah + 2010-10-04T01:51:47Z + cellular_component + GO:0071944 + + cell periphery + + + + + The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. + GOC:mah + + + + + + + + - - + + - Any process that activates or increases the frequency, rate or extent of mesoderm development. - vk - 2011-02-15T03:10:12Z - biological_process - GO:2000382 - positive regulation of mesoderm development + An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. + mah + 2010-10-11T11:44:57Z + elastic fibre + elastin fiber + cellular_component + GO:0071953 + elastic fiber - + - Any process that activates or increases the frequency, rate or extent of mesoderm development. - GOC:BHF + An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. + GOC:BHF + GOC:mah + PMID:20236620 + + + + + elastic fibre + GOC:mah + + + + + elastin fiber + GOC:BHF - + - - - - - - - - - - - - - + + - - + + - Any process that modulates the frequency, rate or extent of ectoderm development. - vk - 2011-02-15T03:17:10Z + The developmental process pertaining to the initial formation of an epithelial tube. + https://github.com/geneontology/go-ontology/issues/22302 + mah + 2010-02-26T02:15:40Z biological_process - GO:2000383 - regulation of ectoderm development + GO:0072175 + epithelial tube formation - + - Any process that modulates the frequency, rate or extent of ectoderm development. - GOC:BHF + The developmental process pertaining to the initial formation of an epithelial tube. + GOC:mtg_kidney_jan10 - + - + - + - - + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development. - vk - 2011-02-15T03:17:27Z + Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + mah + 2010-03-01T03:43:29Z biological_process - GO:2000384 - negative regulation of ectoderm development + GO:0072201 + negative regulation of mesenchymal cell proliferation - + - Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development. - GOC:BHF + Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + GOC:mtg_kidney_jan10 - + - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of ectoderm development. - vk - 2011-02-15T03:17:39Z + + + + The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. + mah + 2010-11-02T04:51:32Z + monocarboxylic acid anabolism + monocarboxylic acid biosynthesis + monocarboxylic acid formation + monocarboxylic acid synthesis biological_process - GO:2000385 - positive regulation of ectoderm development + GO:0072330 + monocarboxylic acid biosynthetic process - + - Any process that activates or increases the frequency, rate or extent of ectoderm development. - GOC:BHF + The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. + GOC:mah + + + + + monocarboxylic acid anabolism + GOC:mah + + + + + monocarboxylic acid biosynthesis + GOC:mah + + + + + monocarboxylic acid formation + GOC:mah + + + + + monocarboxylic acid synthesis + GOC:mah + + + + + + + + + The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. + mah + 2010-11-16T11:27:39Z + GO:0072358 + cardiovascular system development + biological_process + GO:0072359 + + circulatory system development + + + + + The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. + GOC:mah + UBERON:0001009 - + - + - + - + - + - Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. - bf - 2011-03-18T02:18:34Z + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. + dhl + 2009-04-22T04:30:52Z biological_process - GO:2000495 - regulation of cell proliferation involved in compound eye morphogenesis + GO:0080090 + regulation of primary metabolic process - + - Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. - GOC:obol + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. + PMID:19211694 - + - + - - + + - - + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. - bf - 2011-03-18T02:19:22Z + Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + tb + 2009-10-23T11:21:38Z biological_process - GO:2000496 - negative regulation of cell proliferation involved in compound eye morphogenesis + GO:0090087 + regulation of peptide transport - + - Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. - GOC:obol + Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:dph + GOC:tb - + - + - - + + - - + - - + + - Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. - bf - 2011-03-18T02:19:54Z + Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. + tb + 2010-02-03T11:48:13Z biological_process - GO:2000497 - positive regulation of cell proliferation involved in compound eye morphogenesis + GO:0090257 + regulation of muscle system process - + - Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. - GOC:obol + Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. + GOC:dph + GOC:tb - + - + - - + + - - + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation. - yaf - 2011-04-01T04:10:08Z + Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + tb + 2010-02-05T02:54:14Z biological_process - GO:2000542 - negative regulation of gastrulation + GO:0090273 + regulation of somatostatin secretion - + - Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation. - GOC:obol + Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + GOC:BHF - + - + - + - - + + - + - Any process that activates or increases the frequency, rate or extent of gastrulation. - yaf - 2011-04-01T04:10:15Z + Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + tb + 2010-02-05T02:54:14Z biological_process - GO:2000543 - positive regulation of gastrulation + GO:0090274 + positive regulation of somatostatin secretion - + - Any process that activates or increases the frequency, rate or extent of gastrulation. - GOC:obol + Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + GOC:BHF - + - + - - + + - - - + + - - + + - Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. - yaf - 2011-04-04T10:01:20Z - positive regulation of DNA anabolism - positive regulation of DNA biosynthesis - positive regulation of DNA formation - positive regulation of DNA synthesis + Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + tb + 2010-02-05T02:54:14Z biological_process - GO:2000573 - positive regulation of DNA biosynthetic process + GO:0090275 + negative regulation of somatostatin secretion - + - Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. - GOC:obol - - - - - positive regulation of DNA anabolism - GOC:obol - - - - - positive regulation of DNA biosynthesis - GOC:obol - - - - - positive regulation of DNA formation - GOC:obol - - - - - positive regulation of DNA synthesis - GOC:obol + Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + GOC:BHF - + - + - - + + - - + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. - dph - 2011-04-27T01:04:22Z + Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + tb + 2010-02-05T02:56:39Z biological_process - GO:2000647 - negative regulation of stem cell proliferation + GO:0090276 + regulation of peptide hormone secretion - + - Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. - GOC:dph + Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + GOC:tb - + - + - + - - + + + - + - Any process that activates or increases the frequency, rate or extent of stem cell proliferation. - dph - 2011-04-27T01:04:25Z + Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + tb + 2010-02-05T02:56:39Z biological_process - GO:2000648 - positive regulation of stem cell proliferation + GO:0090277 + positive regulation of peptide hormone secretion - + - Any process that activates or increases the frequency, rate or extent of stem cell proliferation. - GOC:dph + Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + GOC:tb - + - + - - + + - - - - - - - - + + + - - + + - Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. - yaf - 2011-04-28T08:42:53Z - regulation of sodium transporter activity + Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + tb + 2010-02-05T02:56:39Z biological_process - GO:2000649 - - regulation of sodium ion transmembrane transporter activity + GO:0090278 + negative regulation of peptide hormone secretion - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. - GOC:obol - - - - - regulation of sodium transporter activity - GOC:obol + Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + GOC:tb - + - + - - + + - - - - - - - - - + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity. - yaf - 2011-04-28T08:42:57Z - negative regulation of sodium transporter activity + Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + tb + 2010-05-14T10:24:29Z biological_process - GO:2000650 - - negative regulation of sodium ion transmembrane transporter activity + GO:0090325 + regulation of locomotion involved in locomotory behavior - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity. - GOC:obol - - - - - negative regulation of sodium transporter activity - GOC:obol + Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + GOC:dph + GOC:kmv + GOC:tb - + - + - + - + - - - - - - - - - + + + - + - Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity. - yaf - 2011-04-28T08:43:00Z - positive regulation of sodium transporter activity + Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + tb + 2010-05-14T10:26:58Z biological_process - GO:2000651 - - positive regulation of sodium ion transmembrane transporter activity + GO:0090326 + positive regulation of locomotion involved in locomotory behavior - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity. - GOC:obol - - - - - positive regulation of sodium transporter activity - GOC:obol + Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + GOC:dph + GOC:kmv + GOC:tb - + - + - - + + - + + + - - + + - Any process that modulates the frequency, rate or extent of motor neuron apoptotic process. - pr - 2011-05-09T10:56:17Z - regulation of motoneuron apoptosis - regulation of motor neuron apoptosis + Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + tb + 2010-05-14T10:26:58Z biological_process - GO:2000671 - regulation of motor neuron apoptotic process + GO:0090327 + negative regulation of locomotion involved in locomotory behavior - + - Any process that modulates the frequency, rate or extent of motor neuron apoptotic process. - GOC:mtg_apoptosis - GOC:obol + Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + GOC:dph + GOC:kmv + GOC:tb + + + + + + + + + The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. + https://github.com/geneontology/go-ontology/issues/22368 + pr + 2012-03-05T02:03:58Z + biological_process + GO:0097254 + renal tubular secretion + - - - regulation of motoneuron apoptosis - GOC:obol + + + The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. + GOC:rph + PMID:25287933 + Wikipedia:Renal_secretion#Secretion - + - + - + - - + + - - + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process. + A prolongation or process extending from a glial cell. pr - 2011-05-09T10:56:21Z - negative regulation of motoneuron apoptosis - negative regulation of motor neuron apoptosis - biological_process - GO:2000672 - negative regulation of motor neuron apoptotic process + 2012-10-22T13:55:54Z + cellular_component + glial process + glial projection + GO:0097386 + glial cell projection - + - Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process. - GOC:mtg_apoptosis - GOC:obol - - - - - negative regulation of motoneuron apoptosis - GOC:obol + A prolongation or process extending from a glial cell. + GOC:mc - + - + - + - - + + - - + + - - + + - Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process. + Any vesicle that is part of the intracellular region. pr - 2011-05-09T10:56:24Z - positive regulation of motoneuron apoptosis - positive regulation of motor neuron apoptosis - biological_process - GO:2000673 - positive regulation of motor neuron apoptotic process + 2016-03-29T17:39:45Z + cellular_component + GO:0097708 + intracellular vesicle - + - Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process. - GOC:mtg_apoptosis - GOC:obol - - - - - positive regulation of motoneuron apoptosis - GOC:obol + Any vesicle that is part of the intracellular region. + GOC:vesicles - + - + - + - - + + - + - - + + - Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process. - pr - 2011-05-09T11:51:09Z - regulation of pancreatic B cell apoptosis - regulation of pancreatic beta cell apoptosis - regulation of type B pancreatic cell apoptosis - biological_process - GO:2000674 - regulation of type B pancreatic cell apoptotic process + A membrane that is a (regional) part of the plasma membrane. + dos + 2014-03-06T11:55:32Z + region of plasma membrane + cellular_component + GO:0098590 + + Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. + plasma membrane region - + - Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process. - GOC:mtg_apoptosis - GOC:obol - - - - - regulation of pancreatic B cell apoptosis - GOC:obol - - - - - regulation of pancreatic beta cell apoptosis - GOC:obol + A membrane that is a (regional) part of the plasma membrane. + GOC:dos - + - + - + - - + + - - + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process. - pr - 2011-05-09T11:51:12Z - negative regulation of pancreatic B cell apoptosis - negative regulation of pancreatic beta cell apoptosis - negative regulation of type B pancreatic cell apoptosis - biological_process - GO:2000675 - negative regulation of type B pancreatic cell apoptotic process + A collagen trimer that forms networks. + cellular_component + GO:0098642 + network-forming collagen trimer - + - Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process. - GOC:mtg_apoptosis - GOC:obol - - - - - negative regulation of pancreatic B cell apoptosis - GOC:obol + A collagen trimer that forms networks. + PMID:21421911 + + + + + + + + + A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). + cellular_component + GO:0098643 + banded collagen fibril + - - - negative regulation of pancreatic beta cell apoptosis - GOC:obol + + + A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). + GOC:dos + PMID:21421911 - + - - - - - - - - - - - - - - + + - - + + - Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process. - pr - 2011-05-09T11:51:15Z - positive regulation of pancreatic B cell apoptosis - positive regulation of pancreatic beta cell apoptosis - positive regulation of type B pancreatic cell apoptosis - biological_process - GO:2000676 - positive regulation of type B pancreatic cell apoptotic process + + + + + + + A complex of collagen trimers such as a fibril or collagen network. + Supramolecular aggregate of collagen + Supramolecular collagen assembly + cellular_component + GO:0098644 + complex of collagen trimers - + - Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process. - GOC:mtg_apoptosis - GOC:obol + A complex of collagen trimers such as a fibril or collagen network. + GOC:dos - + - positive regulation of pancreatic B cell apoptosis - GOC:obol + Supramolecular aggregate of collagen + PMID:19693541 - + - positive regulation of pancreatic beta cell apoptosis - GOC:obol + Supramolecular collagen assembly + PMID:21421911 + + + + + + + + + + A supramolecular complex that consists of collagen triple helices associated to form a network. + cellular_component + GO:0098645 + collagen network + + + + + A supramolecular complex that consists of collagen triple helices associated to form a network. + GOC:dos + PMID:21421911 - + - + - + - - + + - - + - - + + - Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation. - yaf - 2011-05-25T09:08:01Z - regulation of myocardial precursor cell differentiation - biological_process - regulation of cardiac myoblast differentiation - GO:2000690 - regulation of cardiac muscle cell myoblast differentiation + Any collagen timer that is part of a basement membrane. + cellular_component + GO:0098651 + basement membrane collagen trimer - + - Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation. - GOC:obol - - - - - regulation of myocardial precursor cell differentiation - GOC:obol - - - - - regulation of cardiac myoblast differentiation - GOC:obol + Any collagen timer that is part of a basement membrane. + GOC:dos + PMID:21421911 - + - + - + - - + + - - - + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation. - yaf - 2011-05-25T09:08:06Z - negative regulation of myocardial precursor cell differentiation - biological_process - negative regulation of cardiac myoblast differentiation - GO:2000691 - negative regulation of cardiac muscle cell myoblast differentiation + Any protein complex that is part of a membrane. + cellular_component + GO:0098796 + + membrane protein complex - + - Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation. - GOC:obol - - - - - negative regulation of myocardial precursor cell differentiation - GOC:obol - - - - - negative regulation of cardiac myoblast differentiation - GOC:obol + Any protein complex that is part of a membrane. + GOC:dos - + - + - + - - + + - - - + - - + + - Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation. - yaf - 2011-05-25T09:08:09Z - positive regulation of myocardial precursor cell differentiation - biological_process - positive regulation of cardiac myoblast differentiation - GO:2000700 - positive regulation of cardiac muscle cell myoblast differentiation + Any protein complex that is part of the plasma membrane. + cellular_component + GO:0098797 + plasma membrane protein complex - + - Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation. - GOC:obol - - - - - positive regulation of myocardial precursor cell differentiation - GOC:obol - - - - - positive regulation of cardiac myoblast differentiation - GOC:obol + Any protein complex that is part of the plasma membrane. + GOC:dos - + - + - + - - + - + - Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation. - vk - 2011-06-08T10:51:06Z - regulation of cardiomyocyte differentiation + Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. biological_process - regulation of heart muscle cell differentiation - GO:2000725 - regulation of cardiac muscle cell differentiation + GO:0098801 + regulation of renal system process - + - Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation. - GOC:BHF - - - - - regulation of cardiomyocyte differentiation - GOC:obol - - - - - regulation of heart muscle cell differentiation - GOC:obol + Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. + GOC:dos - + - - - - - - - - - - - - - - - + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation. - vk - 2011-06-08T10:51:11Z - negative regulation of cardiomyocyte differentiation - biological_process - negative regulation of heart muscle cell differentiation - GO:2000726 - negative regulation of cardiac muscle cell differentiation + A cell projection supported by an assembly of actin filaments, and which lacks microtubules. + cellular_component + GO:0098858 + actin-based cell projection + + + + + A cell projection supported by an assembly of actin filaments, and which lacks microtubules. + PMID:15661519 + + + + + + + + + A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. + cellular_component + GO:0099080 + supramolecular complex - + - Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation. - GOC:BHF + A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. + GOC:dos + + + + + + + + A polymeric supramolecular structure. + cellular_component + GO:0099081 + supramolecular polymer + - - - negative regulation of cardiomyocyte differentiation - GOC:obol + + + A polymeric supramolecular structure. + GOC:dos + + + + + + + + A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. + GO:0043205 + cellular_component + fibril + GO:0099512 + supramolecular fiber + - - - negative regulation of heart muscle cell differentiation - GOC:obol + + + A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. + GOC:dos + + + + + + + + + + + + + + + A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits. + cellular_component + GO:0099513 + polymeric cytoskeletal fiber + + + + + A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits. + GOC:dos - + - + - + - - + + - - - + - - + + - Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. - vk - 2011-06-08T10:51:15Z - positive regulation of cardiomyocyte differentiation - biological_process - positive regulation of heart muscle cell differentiation - GO:2000727 - positive regulation of cardiac muscle cell differentiation + Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. + cellular_component + GO:0099568 + + cytoplasmic region - + - Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. - GOC:BHF - - - - - positive regulation of cardiomyocyte differentiation - GOC:obol - - - - - positive regulation of heart muscle cell differentiation - GOC:obol + Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. + GOC:dos - + - + - + - - + + - + + - - + + - Any process that modulates the frequency, rate or extent of stem cell differentiation. - yaf - 2011-06-14T02:05:16Z - biological_process - GO:2000736 - regulation of stem cell differentiation + The complete extent of cell cortex that underlies some some region of the plasma membrane. + perimembrane region + cellular_component + GO:0099738 + + cell cortex region - + - Any process that modulates the frequency, rate or extent of stem cell differentiation. - GOC:obol + The complete extent of cell cortex that underlies some some region of the plasma membrane. + GOC:dos + + + + + + + + + A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. + kmv + 2019-08-12T18:01:37Z + cellular_component + GO:0110165 + cellular anatomical entity + + + + + A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. + GOC:kmv - + - + - + - - + + - - + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. - yaf - 2011-06-14T02:05:20Z - biological_process - GO:2000737 - negative regulation of stem cell differentiation + A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. + https://github.com/geneontology/go-ontology/issues/13193 + krc + 2017-03-21T17:26:07Z + cellular_component + GO:0120025 + plasma membrane bounded cell projection - + - Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. - GOC:obol + A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. + GOC:krc - + - + - + - - + + - - + - - + + - Any process that activates or increases the frequency, rate or extent of stem cell differentiation. - yaf - 2011-06-14T02:05:23Z + All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection. + https://github.com/geneontology/go-ontology/issues/14472 + krc + 2017-11-01T18:58:12Z + cellular_component + GO:0120111 + neuron projection cytoplasm + + + + + All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection. + GOC:ha + + + + + + + + + + The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis. + pg + 2019-05-22T11:20:45Z + efflux biological_process - GO:2000738 - positive regulation of stem cell differentiation + GO:0140352 + export from cell - + - Any process that activates or increases the frequency, rate or extent of stem cell differentiation. - GOC:obol + The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis. + GOC:pg - + - + - + - + - + - Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. - pr - 2011-06-24T01:53:50Z + Any process that modulates the frequency, rate or extent of vasculature development. + bf + 2012-09-06T09:16:15Z biological_process - GO:2000790 - regulation of mesenchymal cell proliferation involved in lung development + regulation of vascular system development + GO:1901342 + regulation of vasculature development - + - Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. - PMID:21513708 + Any process that modulates the frequency, rate or extent of vasculature development. + GOC:TermGenie + + + + + regulation of vascular system development + GOC:TermGenie - + - + - + - - - - - - - - - - - - - - + - + - Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. - pr - 2011-06-24T01:53:53Z + Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. + bf + 2012-09-06T09:17:24Z + down regulation of vasculature development + down-regulation of vasculature development + downregulation of vasculature development + inhibition of vasculature development + biological_process + down regulation of vascular system development + down-regulation of vascular system development + downregulation of vascular system development + inhibition of vascular system development + negative regulation of vascular system development + GO:1901343 + negative regulation of vasculature development + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. + GOC:TermGenie + + + + + down regulation of vasculature development + GOC:TermGenie + + + + + down-regulation of vasculature development + GOC:TermGenie + + + + + downregulation of vasculature development + GOC:TermGenie + + + + + inhibition of vasculature development + GOC:TermGenie + + + + + down regulation of vascular system development + GOC:TermGenie + + + + + down-regulation of vascular system development + GOC:TermGenie + + + + + downregulation of vascular system development + GOC:TermGenie + + + + + inhibition of vascular system development + GOC:TermGenie + + + + + negative regulation of vascular system development + GOC:TermGenie + + + + + + + + + The chemical reactions and pathways involving organic cyclic compound. + bf + 2012-09-14T09:03:51Z + organic cyclic compound metabolism biological_process - GO:2000791 - negative regulation of mesenchymal cell proliferation involved in lung development + GO:1901360 + organic cyclic compound metabolic process - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 + + + The chemical reactions and pathways involving organic cyclic compound. + GOC:TermGenie - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 + + + organic cyclic compound metabolism + GOC:TermGenie + + + + + + + + + + The chemical reactions and pathways resulting in the formation of organic cyclic compound. + bf + 2012-09-14T09:05:22Z + organic cyclic compound anabolism + organic cyclic compound biosynthesis + organic cyclic compound formation + organic cyclic compound synthesis + biological_process + GO:1901362 + organic cyclic compound biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of organic cyclic compound. + GOC:TermGenie + + + + + organic cyclic compound anabolism + GOC:TermGenie + + + + + organic cyclic compound biosynthesis + GOC:TermGenie + + + + + organic cyclic compound formation + GOC:TermGenie - + + + organic cyclic compound synthesis + GOC:TermGenie + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon. + pr + 2012-11-05T11:04:36Z + organic molecular entity breakdown + organic molecular entity catabolic process + organic molecular entity catabolism + organic molecular entity degradation + organic substance breakdown + organic substance catabolism + organic substance degradation + biological_process + GO:1901575 + organic substance catabolic process + + + - Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. - PMID:21513708 + The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon. + GOC:TermGenie + GOC:pr + + + + + organic molecular entity breakdown + GOC:TermGenie + + + + + organic molecular entity catabolism + GOC:TermGenie + + + + + organic molecular entity degradation + GOC:TermGenie - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. + + + + The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. pr - 2011-06-24T01:53:56Z + 2012-11-05T11:04:40Z + organic molecular entity anabolism + organic molecular entity biosynthesis + organic molecular entity biosynthetic process + organic molecular entity formation + organic molecular entity synthesis + organic substance anabolism + organic substance biosynthesis + organic substance formation + organic substance synthesis biological_process - GO:2000792 - positive regulation of mesenchymal cell proliferation involved in lung development + GO:1901576 + organic substance biosynthetic process - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 + + + The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. + GOC:TermGenie + GOC:pr + + + + + organic molecular entity anabolism + GOC:TermGenie + + + + + organic molecular entity biosynthesis + GOC:TermGenie + + + + + organic molecular entity formation + GOC:TermGenie + + + + + organic molecular entity synthesis + GOC:TermGenie + + + + + + + + The chemical reactions and pathways involving organic hydroxy compound. + pr + 2012-11-13T12:54:27Z + organic hydroxy compound metabolism + biological_process + GO:1901615 + organic hydroxy compound metabolic process + - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 + + + The chemical reactions and pathways involving organic hydroxy compound. + GOC:TermGenie + GOC:pr - - - Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. - PMID:21513708 + + + organic hydroxy compound metabolism + GOC:TermGenie - + - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. + + + + The chemical reactions and pathways resulting in the formation of organic hydroxy compound. pr - 2011-06-25T07:22:38Z + 2012-11-13T12:54:36Z + organic hydroxy compound anabolism + organic hydroxy compound biosynthesis + organic hydroxy compound formation + organic hydroxy compound synthesis biological_process - GO:2000794 - regulation of epithelial cell proliferation involved in lung morphogenesis + GO:1901617 + organic hydroxy compound biosynthetic process - + - Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. - PMID:21513708 + The chemical reactions and pathways resulting in the formation of organic hydroxy compound. + GOC:TermGenie + GOC:pr + + + + + organic hydroxy compound anabolism + GOC:TermGenie + + + + + organic hydroxy compound biosynthesis + GOC:TermGenie + + + + + organic hydroxy compound formation + GOC:TermGenie + + + + + organic hydroxy compound synthesis + GOC:TermGenie - + - + - - + + - - + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. - pr - 2011-06-25T07:22:42Z + Any process that modulates the frequency, rate or extent of blood circulation. + mr + 2014-10-06T18:38:56Z biological_process - GO:2000795 - negative regulation of epithelial cell proliferation involved in lung morphogenesis + regulation of hemolymph circulation + GO:1903522 + regulation of blood circulation - + - Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. - PMID:21513708 + Any process that modulates the frequency, rate or extent of blood circulation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:10659969 + + + + + regulation of hemolymph circulation + GOC:TermGenie - + - + - + - - + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation. - pr - 2011-07-12T03:06:04Z + Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. + mr + 2014-10-06T18:39:05Z + down regulation of blood circulation + down-regulation of blood circulation + downregulation of blood circulation + inhibition of blood circulation biological_process - GO:2000818 - negative regulation of myoblast proliferation + down regulation of hemolymph circulation + down-regulation of hemolymph circulation + downregulation of hemolymph circulation + inhibition of hemolymph circulation + negative regulation of hemolymph circulation + GO:1903523 + negative regulation of blood circulation - + - Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation. - GOC:obol + Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:10659969 + + + + + down regulation of blood circulation + GOC:TermGenie + + + + + down-regulation of blood circulation + GOC:TermGenie + + + + + downregulation of blood circulation + GOC:TermGenie + + + + + inhibition of blood circulation + GOC:TermGenie + + + + + down regulation of hemolymph circulation + GOC:TermGenie + + + + + down-regulation of hemolymph circulation + GOC:TermGenie + + + + + downregulation of hemolymph circulation + GOC:TermGenie + + + + + inhibition of hemolymph circulation + GOC:TermGenie + + + + + negative regulation of hemolymph circulation + GOC:TermGenie - + - + - - + + - + + - - + + - Any process that modulates the frequency, rate or extent of heart morphogenesis. - vk - 2011-07-19T10:08:58Z + Any process that activates or increases the frequency, rate or extent of blood circulation. + mr + 2014-10-06T18:39:13Z + up regulation of blood circulation + up-regulation of blood circulation + upregulation of blood circulation + activation of blood circulation biological_process - regulation of cardiac morphogenesis - GO:2000826 - regulation of heart morphogenesis + activation of hemolymph circulation + positive regulation of hemolymph circulation + up regulation of hemolymph circulation + up-regulation of hemolymph circulation + upregulation of hemolymph circulation + GO:1903524 + positive regulation of blood circulation - + - Any process that modulates the frequency, rate or extent of heart morphogenesis. - GOC:BHF + Any process that activates or increases the frequency, rate or extent of blood circulation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:10659969 + + + + + up regulation of blood circulation + GOC:TermGenie + + + + + up-regulation of blood circulation + GOC:TermGenie + + + + + upregulation of blood circulation + GOC:TermGenie + + + + + activation of blood circulation + GOC:TermGenie - + - regulation of cardiac morphogenesis - GOC:obol + activation of hemolymph circulation + GOC:TermGenie + + + + + positive regulation of hemolymph circulation + GOC:TermGenie + + + + + up regulation of hemolymph circulation + GOC:TermGenie + + + + + up-regulation of hemolymph circulation + GOC:TermGenie + + + + + upregulation of hemolymph circulation + GOC:TermGenie - + - + - + - - - + + - + - Any process that modulates the frequency, rate or extent of steroid hormone secretion. - bf - 2011-07-26T08:38:46Z + Any process that modulates the frequency, rate or extent of secretion by cell. + pm + 2014-10-08T13:24:59Z + regulation of cellular secretion biological_process - GO:2000831 - regulation of steroid hormone secretion + GO:1903530 + regulation of secretion by cell - + - Any process that modulates the frequency, rate or extent of steroid hormone secretion. - GOC:sl + Any process that modulates the frequency, rate or extent of secretion by cell. + GOC:TermGenie + GOC:pm + GO_REF:0000058 + PMID:12130530 + + + + + regulation of cellular secretion + GOC:TermGenie - + - + - + - - - - + + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion. - bf - 2011-07-26T08:38:50Z + Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell. + pm + 2014-10-08T13:25:08Z + down regulation of cellular secretion + down regulation of secretion by cell + down-regulation of cellular secretion + down-regulation of secretion by cell + downregulation of cellular secretion + downregulation of secretion by cell + negative regulation of cellular secretion + inhibition of cellular secretion + inhibition of secretion by cell biological_process - GO:2000832 - negative regulation of steroid hormone secretion + GO:1903531 + negative regulation of secretion by cell - + - Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion. - GOC:sl + Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell. + GOC:TermGenie + GOC:pm + GO_REF:0000058 + PMID:12130530 + + + + + down regulation of cellular secretion + GOC:TermGenie + + + + + down regulation of secretion by cell + GOC:TermGenie + + + + + down-regulation of cellular secretion + GOC:TermGenie + + + + + down-regulation of secretion by cell + GOC:TermGenie + + + + + downregulation of cellular secretion + GOC:TermGenie + + + + + downregulation of secretion by cell + GOC:TermGenie + + + + + negative regulation of cellular secretion + GOC:TermGenie + + + + + inhibition of cellular secretion + GOC:TermGenie + + + + + inhibition of secretion by cell + GOC:TermGenie - + - + - + - - - - + + + - + - Any process that activates or increases the frequency, rate or extent of steroid hormone secretion. - bf - 2011-07-26T08:38:51Z + Any process that activates or increases the frequency, rate or extent of secretion by cell. + pm + 2014-10-08T13:25:17Z + positive regulation of cellular secretion + up regulation of cellular secretion + up regulation of secretion by cell + up-regulation of cellular secretion + up-regulation of secretion by cell + upregulation of cellular secretion + upregulation of secretion by cell + activation of cellular secretion + activation of secretion by cell biological_process - GO:2000833 - positive regulation of steroid hormone secretion + GO:1903532 + positive regulation of secretion by cell - + - Any process that activates or increases the frequency, rate or extent of steroid hormone secretion. - GOC:sl + Any process that activates or increases the frequency, rate or extent of secretion by cell. + GOC:TermGenie + GOC:pm + GO_REF:0000058 + PMID:12130530 + + + + + positive regulation of cellular secretion + GOC:TermGenie + + + + + up regulation of cellular secretion + GOC:TermGenie + + + + + up regulation of secretion by cell + GOC:TermGenie + + + + + up-regulation of cellular secretion + GOC:TermGenie + + + + + up-regulation of secretion by cell + GOC:TermGenie + + + + + upregulation of cellular secretion + GOC:TermGenie + + + + + upregulation of secretion by cell + GOC:TermGenie + + + + + activation of cellular secretion + GOC:TermGenie + + + + + activation of secretion by cell + GOC:TermGenie - + - + - + - - + + - + + - - + + - Any process that modulates the frequency, rate or extent of androgen secretion. - bf - 2011-07-26T08:39:45Z - biological_process - GO:2000834 - regulation of androgen secretion + Any vesicle that is part of the extracellular region. + jl + 2014-10-22T14:26:11Z + cellular_component + microparticle + GO:1903561 + extracellular vesicle - + - Any process that modulates the frequency, rate or extent of androgen secretion. - GOC:sl + Any vesicle that is part of the extracellular region. + GOC:TermGenie + GOC:pm + GO_REF:0000064 + PMID:24769233 + + + + + microparticle + GOC:vesicles - + - + - - + + - - + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion. - bf - 2011-07-26T08:39:48Z + Any process that modulates the frequency, rate or extent of hemopoiesis. + pad + 2014-12-04T15:34:13Z + regulation of blood cell biosynthesis + regulation of blood cell formation + regulation of haemopoiesis + regulation of hematopoiesis biological_process - GO:2000835 - negative regulation of androgen secretion + GO:1903706 + An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. + regulation of hemopoiesis - + - Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion. - GOC:sl + Any process that modulates the frequency, rate or extent of hemopoiesis. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:20080761 + + + + + regulation of blood cell biosynthesis + GOC:TermGenie + + + + + regulation of blood cell formation + GOC:TermGenie + + + + + regulation of haemopoiesis + GOC:TermGenie + + + + + regulation of hematopoiesis + GOC:TermGenie - + - + - - + + - - + + + + - - + + - Any process that activates or increases the frequency, rate or extent of androgen secretion. - bf - 2011-07-26T08:39:51Z + Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. + pad + 2014-12-04T15:34:21Z + down regulation of blood cell biosynthesis + down regulation of blood cell formation + down regulation of haemopoiesis + down regulation of hematopoiesis + down regulation of hemopoiesis + down-regulation of blood cell biosynthesis + down-regulation of blood cell formation + down-regulation of haemopoiesis + down-regulation of hematopoiesis + down-regulation of hemopoiesis + downregulation of blood cell biosynthesis + downregulation of blood cell formation + downregulation of haemopoiesis + downregulation of hematopoiesis + downregulation of hemopoiesis + negative regulation of blood cell biosynthesis + negative regulation of blood cell formation + negative regulation of haemopoiesis + negative regulation of hematopoiesis + inhibition of blood cell biosynthesis + inhibition of blood cell formation + inhibition of haemopoiesis + inhibition of hematopoiesis + inhibition of hemopoiesis biological_process - GO:2000836 - positive regulation of androgen secretion + GO:1903707 + An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. + negative regulation of hemopoiesis - + - Any process that activates or increases the frequency, rate or extent of androgen secretion. - GOC:sl + Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:20080761 - - - - - - - - - - - - - - - - - - - - - - - - - The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state. - yaf - 2011-08-09T04:05:14Z - biological_process - mesenchymal cell differentiation involved in urinary system development - mesenchymal cell differentiation involved in urinary tract development - GO:2001012 - mesenchymal cell differentiation involved in renal system development - - - - The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state. - GOC:mtg_kidney_jan10 - GOC:obol - GOC:yaf + + + down regulation of blood cell biosynthesis + GOC:TermGenie - - - mesenchymal cell differentiation involved in urinary system development - GOC:obol + + + down regulation of blood cell formation + GOC:TermGenie - - - mesenchymal cell differentiation involved in urinary tract development - GOC:obol + + + down regulation of haemopoiesis + GOC:TermGenie + + + + + down regulation of hematopoiesis + GOC:TermGenie + + + + + down regulation of hemopoiesis + GOC:TermGenie + + + + + down-regulation of blood cell biosynthesis + GOC:TermGenie + + + + + down-regulation of blood cell formation + GOC:TermGenie + + + + + down-regulation of haemopoiesis + GOC:TermGenie + + + + + down-regulation of hematopoiesis + GOC:TermGenie + + + + + down-regulation of hemopoiesis + GOC:TermGenie + + + + + downregulation of blood cell biosynthesis + GOC:TermGenie + + + + + downregulation of blood cell formation + GOC:TermGenie + + + + + downregulation of haemopoiesis + GOC:TermGenie + + + + + downregulation of hematopoiesis + GOC:TermGenie + + + + + downregulation of hemopoiesis + GOC:TermGenie + + + + + negative regulation of blood cell biosynthesis + GOC:TermGenie + + + + + negative regulation of blood cell formation + GOC:TermGenie + + + + + negative regulation of haemopoiesis + GOC:TermGenie + + + + + negative regulation of hematopoiesis + GOC:TermGenie + + + + + inhibition of blood cell biosynthesis + GOC:TermGenie + + + + + inhibition of blood cell formation + GOC:TermGenie + + + + + inhibition of haemopoiesis + GOC:TermGenie + + + + + inhibition of hematopoiesis + GOC:TermGenie + + + + + inhibition of hemopoiesis + GOC:TermGenie - + - + - - + + - + + + + - - + + - Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. - yaf - 2011-08-11T08:54:37Z + Any process that activates or increases the frequency, rate or extent of hemopoiesis. + pad + 2014-12-04T15:34:30Z + positive regulation of blood cell biosynthesis + positive regulation of blood cell formation + positive regulation of haemopoiesis + positive regulation of hematopoiesis + up regulation of blood cell biosynthesis + up regulation of blood cell formation + up regulation of haemopoiesis + up regulation of hematopoiesis + up regulation of hemopoiesis + up-regulation of blood cell biosynthesis + up-regulation of blood cell formation + up-regulation of haemopoiesis + up-regulation of hematopoiesis + up-regulation of hemopoiesis + upregulation of blood cell biosynthesis + upregulation of blood cell formation + upregulation of haemopoiesis + upregulation of hematopoiesis + upregulation of hemopoiesis + activation of blood cell biosynthesis + activation of blood cell formation + activation of haemopoiesis + activation of hematopoiesis + activation of hemopoiesis biological_process - GO:2001014 - regulation of skeletal muscle cell differentiation + GO:1903708 + An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. + positive regulation of hemopoiesis - + - Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. - GOC:obol + Any process that activates or increases the frequency, rate or extent of hemopoiesis. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:20080761 + + + + + positive regulation of blood cell biosynthesis + GOC:TermGenie + + + + + positive regulation of blood cell formation + GOC:TermGenie + + + + + positive regulation of haemopoiesis + GOC:TermGenie + + + + + positive regulation of hematopoiesis + GOC:TermGenie + + + + + up regulation of blood cell biosynthesis + GOC:TermGenie + + + + + up regulation of blood cell formation + GOC:TermGenie + + + + + up regulation of haemopoiesis + GOC:TermGenie + + + + + up regulation of hematopoiesis + GOC:TermGenie + + + + + up regulation of hemopoiesis + GOC:TermGenie + + + + + up-regulation of blood cell biosynthesis + GOC:TermGenie + + + + + up-regulation of blood cell formation + GOC:TermGenie + + + + + up-regulation of haemopoiesis + GOC:TermGenie + + + + + up-regulation of hematopoiesis + GOC:TermGenie + + + + + up-regulation of hemopoiesis + GOC:TermGenie + + + + + upregulation of blood cell biosynthesis + GOC:TermGenie + + + + + upregulation of blood cell formation + GOC:TermGenie + + + + + upregulation of haemopoiesis + GOC:TermGenie + + + + + upregulation of hematopoiesis + GOC:TermGenie + + + + + upregulation of hemopoiesis + GOC:TermGenie + + + + + activation of blood cell biosynthesis + GOC:TermGenie + + + + + activation of blood cell formation + GOC:TermGenie + + + + + activation of haemopoiesis + GOC:TermGenie + + + + + activation of hematopoiesis + GOC:TermGenie + + + + + activation of hemopoiesis + GOC:TermGenie - + - + - + - - + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation. - yaf - 2011-08-11T08:54:41Z + Any process that stops, prevents or reduces the frequency, rate or extent of anion transport. + sl + 2015-01-12T21:50:20Z + down regulation of anion transport + down-regulation of anion transport + downregulation of anion transport + inhibition of anion transport biological_process - GO:2001015 - negative regulation of skeletal muscle cell differentiation + GO:1903792 + negative regulation of anion transport - + - Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation. - GOC:obol + Any process that stops, prevents or reduces the frequency, rate or extent of anion transport. + GOC:TermGenie + GO_REF:0000058 + PMID:11336802 + + + + + down regulation of anion transport + GOC:TermGenie + + + + + down-regulation of anion transport + GOC:TermGenie + + + + + downregulation of anion transport + GOC:TermGenie + + + + + inhibition of anion transport + GOC:TermGenie - + - + - + - - + + - + - Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation. - yaf - 2011-08-11T08:54:44Z + Any process that activates or increases the frequency, rate or extent of anion transport. + sl + 2015-01-12T21:50:30Z + up regulation of anion transport + up-regulation of anion transport + upregulation of anion transport + activation of anion transport biological_process - GO:2001016 - positive regulation of skeletal muscle cell differentiation + GO:1903793 + positive regulation of anion transport - + - Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation. - GOC:obol + Any process that activates or increases the frequency, rate or extent of anion transport. + GOC:TermGenie + GO_REF:0000058 + PMID:11336802 + + + + + up regulation of anion transport + GOC:TermGenie + + + + + up-regulation of anion transport + GOC:TermGenie + + + + + upregulation of anion transport + GOC:TermGenie + + + + + activation of anion transport + GOC:TermGenie - + - + - - + + - + + - - + + - Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process. - yaf - 2011-09-08T02:49:59Z - regulation of mesenchymal cell apoptosis + Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization. + https://github.com/geneontology/go-ontology/issues/22021 + jl + 2015-01-20T14:32:24Z + down regulation of cellular protein localisation + down regulation of cellular protein localization + down-regulation of cellular protein localisation + down-regulation of cellular protein localization + downregulation of cellular protein localisation + downregulation of cellular protein localization + negative regulation of cellular protein localisation + negative regulation of cellular protein localization + inhibition of cellular protein localisation + inhibition of cellular protein localization biological_process - GO:2001053 - regulation of mesenchymal cell apoptotic process + GO:1903828 + negative regulation of protein localization - + - Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process. - GOC:mtg_apoptosis - GOC:obol + Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + + + + + down regulation of cellular protein localisation + GOC:TermGenie + + + + + down regulation of cellular protein localization + GOC:TermGenie + + + + + down-regulation of cellular protein localisation + GOC:TermGenie + + + + + down-regulation of cellular protein localization + GOC:TermGenie + + + + + downregulation of cellular protein localisation + GOC:TermGenie + + + + + downregulation of cellular protein localization + GOC:TermGenie + + + + + negative regulation of cellular protein localisation + GOC:TermGenie + + + + + inhibition of cellular protein localisation + GOC:TermGenie + + + + + inhibition of cellular protein localization + GOC:TermGenie - + - + - - + + - - + + - - + + - Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process. - yaf - 2011-09-08T02:50:05Z - negative regulation of mesenchymal cell apoptosis + Any process that activates or increases the frequency, rate or extent of a protein localization. + https://github.com/geneontology/go-ontology/issues/22021 + jl + 2015-01-20T14:32:33Z + positive regulation of cellular protein localisation + positive regulation of cellular protein localization + up regulation of cellular protein localisation + up regulation of cellular protein localization + up-regulation of cellular protein localisation + up-regulation of cellular protein localization + upregulation of cellular protein localisation + upregulation of cellular protein localization biological_process - GO:2001054 - negative regulation of mesenchymal cell apoptotic process + GO:1903829 + positive regulation of protein localization - - - Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process. - GOC:mtg_apoptosis - GOC:obol + + + Any process that activates or increases the frequency, rate or extent of a protein localization. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + + + + + positive regulation of cellular protein localisation + GOC:TermGenie + + + + + up regulation of cellular protein localisation + GOC:TermGenie + + + + + up regulation of cellular protein localization + GOC:TermGenie + + + + + up-regulation of cellular protein localisation + GOC:TermGenie + + + + + up-regulation of cellular protein localization + GOC:TermGenie + + + + + upregulation of cellular protein localisation + GOC:TermGenie + + + + + upregulation of cellular protein localization + GOC:TermGenie - + - + - - + + - - + + - - + + - Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process. - yaf - 2011-09-08T02:50:09Z - positive regulation of mesenchymal cell apoptosis + Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange. + sl + 2015-02-17T20:26:24Z + down regulation of respiratory gaseous exchange + down-regulation of respiratory gaseous exchange + downregulation of respiratory gaseous exchange + inhibition of respiratory gaseous exchange biological_process - GO:2001055 - positive regulation of mesenchymal cell apoptotic process + GO:1903941 + negative regulation of respiratory gaseous exchange - + - Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process. - GOC:mtg_apoptosis - GOC:obol + Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange. + GOC:TermGenie + GO_REF:0000058 + PMID:22819705 + + + + + down regulation of respiratory gaseous exchange + GOC:TermGenie + + + + + down-regulation of respiratory gaseous exchange + GOC:TermGenie + + + + + downregulation of respiratory gaseous exchange + GOC:TermGenie + + + + + inhibition of respiratory gaseous exchange + GOC:TermGenie - + - + - - + + - - + + - - + + - Any process that modulates the frequency, rate or extent of RNA biosynthetic process. - dph - 2011-10-17T11:36:25Z - regulation of RNA anabolism - regulation of RNA biosynthesis - regulation of RNA formation - regulation of RNA synthesis + Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. + sl + 2015-02-17T20:26:35Z + up regulation of respiratory gaseous exchange + up-regulation of respiratory gaseous exchange + upregulation of respiratory gaseous exchange + activation of respiratory gaseous exchange biological_process - GO:2001141 - regulation of RNA biosynthetic process + GO:1903942 + positive regulation of respiratory gaseous exchange - + - Any process that modulates the frequency, rate or extent of RNA biosynthetic process. - GOC:dph + Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. + GOC:TermGenie + GO_REF:0000058 + PMID:22819705 - + - regulation of RNA anabolism - GOC:obol + up regulation of respiratory gaseous exchange + GOC:TermGenie - + - regulation of RNA biosynthesis - GOC:obol + up-regulation of respiratory gaseous exchange + GOC:TermGenie - + - regulation of RNA formation - GOC:obol + upregulation of respiratory gaseous exchange + GOC:TermGenie - - - regulation of RNA synthesis - GOC:obol + + + activation of respiratory gaseous exchange + GOC:TermGenie - + - + - - + + - + + + - - + + - Any process that modulates the frequency, rate or extent of vasculogenesis. - yaf - 2011-11-15T01:22:31Z - regulation of vascular morphogenesis + Any process that activates or increases the frequency, rate or extent of vasculature development. + sl + 2015-03-06T22:17:04Z + up regulation of vasculature development + up-regulation of vasculature development + upregulation of vasculature development + activation of vasculature development biological_process - GO:2001212 - regulation of vasculogenesis + activation of vascular system development + positive regulation of vascular system development + up regulation of vascular system development + up-regulation of vascular system development + upregulation of vascular system development + GO:1904018 + positive regulation of vasculature development - + - Any process that modulates the frequency, rate or extent of vasculogenesis. - GOC:obol + Any process that activates or increases the frequency, rate or extent of vasculature development. + GOC:TermGenie + GO_REF:0000058 + PMID:21472453 - + - regulation of vascular morphogenesis - GOC:obol + up regulation of vasculature development + GOC:TermGenie + + + + + up-regulation of vasculature development + GOC:TermGenie + + + + + upregulation of vasculature development + GOC:TermGenie + + + + + activation of vasculature development + GOC:TermGenie + + + + + activation of vascular system development + GOC:TermGenie + + + + + positive regulation of vascular system development + GOC:TermGenie + + + + + up regulation of vascular system development + GOC:TermGenie + + + + + up-regulation of vascular system development + GOC:TermGenie + + + + + upregulation of vascular system development + GOC:TermGenie - + - + - + - - + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis. - yaf - 2011-11-15T01:22:36Z - negative regulation of vascular morphogenesis + Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain. + sl + 2015-03-18T20:33:57Z + down regulation of nociception + down regulation of sensory perception of pain + down-regulation of nociception + down-regulation of sensory perception of pain + downregulation of nociception + downregulation of sensory perception of pain + negative regulation of nociception + down regulation of perception of physiological pain + down-regulation of perception of physiological pain + downregulation of perception of physiological pain + inhibition of nociception + inhibition of perception of physiological pain + inhibition of sensory perception of pain + negative regulation of perception of physiological pain biological_process - GO:2001213 - negative regulation of vasculogenesis + GO:1904057 + negative regulation of sensory perception of pain - + - Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis. - GOC:obol + Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain. + GOC:TermGenie + GO_REF:0000058 + PMID:17167094 - + - negative regulation of vascular morphogenesis - GOC:obol + down regulation of nociception + GOC:TermGenie + + + + + down regulation of sensory perception of pain + GOC:TermGenie + + + + + down-regulation of nociception + GOC:TermGenie + + + + + down-regulation of sensory perception of pain + GOC:TermGenie + + + + + downregulation of nociception + GOC:TermGenie + + + + + downregulation of sensory perception of pain + GOC:TermGenie + + + + + negative regulation of nociception + GOC:TermGenie + + + + + down regulation of perception of physiological pain + GOC:TermGenie + + + + + down-regulation of perception of physiological pain + GOC:TermGenie + + + + + downregulation of perception of physiological pain + GOC:TermGenie + + + + + inhibition of nociception + GOC:TermGenie + + + + + inhibition of perception of physiological pain + GOC:TermGenie + + + + + inhibition of sensory perception of pain + GOC:TermGenie + + + + + negative regulation of perception of physiological pain + GOC:TermGenie - + - + - + - - + + - + - Any process that activates or increases the frequency, rate or extent of vasculogenesis. - yaf - 2011-11-15T01:22:39Z - positive regulation of vascular morphogenesis + Any process that activates or increases the frequency, rate or extent of sensory perception of pain. + sl + 2015-03-18T20:34:03Z + positive regulation of nociception + up regulation of nociception + up regulation of sensory perception of pain + up-regulation of nociception + up-regulation of sensory perception of pain + upregulation of nociception + upregulation of sensory perception of pain + activation of nociception + activation of perception of physiological pain + activation of sensory perception of pain + positive regulation of perception of physiological pain + up regulation of perception of physiological pain + up-regulation of perception of physiological pain + upregulation of perception of physiological pain biological_process - GO:2001214 - positive regulation of vasculogenesis + GO:1904058 + positive regulation of sensory perception of pain - + - Any process that activates or increases the frequency, rate or extent of vasculogenesis. - GOC:obol + Any process that activates or increases the frequency, rate or extent of sensory perception of pain. + GOC:TermGenie + GO_REF:0000058 + PMID:17167094 + + + + + positive regulation of nociception + GOC:TermGenie - + - positive regulation of vascular morphogenesis - GOC:obol + up regulation of nociception + GOC:TermGenie + + + + + up regulation of sensory perception of pain + GOC:TermGenie + + + + + up-regulation of nociception + GOC:TermGenie + + + + + up-regulation of sensory perception of pain + GOC:TermGenie + + + + + upregulation of nociception + GOC:TermGenie + + + + + upregulation of sensory perception of pain + GOC:TermGenie + + + + + activation of nociception + GOC:TermGenie + + + + + activation of perception of physiological pain + GOC:TermGenie + + + + + activation of sensory perception of pain + GOC:TermGenie + + + + + positive regulation of perception of physiological pain + GOC:TermGenie + + + + + up regulation of perception of physiological pain + GOC:TermGenie + + + + + up-regulation of perception of physiological pain + GOC:TermGenie + + + + + upregulation of perception of physiological pain + GOC:TermGenie - + - + - + - - - - - - - - + + + - + - Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. - pr - 2011-11-24T01:20:49Z - regulation of apoptotic signalling pathway + Any process that modulates the frequency, rate or extent of bile acid metabolic process. + bf + 2015-05-20T11:04:28Z + regulation of bile acid metabolism biological_process - GO:2001233 - regulation of apoptotic signaling pathway + GO:1904251 + regulation of bile acid metabolic process - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 - - - + - Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. - GOC:mtg_apoptosis + Any process that modulates the frequency, rate or extent of bile acid metabolic process. + GOC:TermGenie + GOC:bf + GO_REF:0000058 - + - regulation of apoptotic signalling pathway - GOC:mah + regulation of bile acid metabolism + GOC:TermGenie - + - + - + - - - - - - - - - + + + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. - pr - 2011-11-24T01:20:54Z - negative regulation of apoptotic signalling pathway + Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process. + bf + 2015-05-20T11:04:35Z + down regulation of bile acid metabolic process + down regulation of bile acid metabolism + down-regulation of bile acid metabolic process + down-regulation of bile acid metabolism + downregulation of bile acid metabolic process + downregulation of bile acid metabolism + negative regulation of bile acid metabolism + inhibition of bile acid metabolic process + inhibition of bile acid metabolism biological_process - GO:2001234 - negative regulation of apoptotic signaling pathway + GO:1904252 + negative regulation of bile acid metabolic process - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 + + + Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process. + GOC:TermGenie + GOC:bf + GO_REF:0000058 - - - Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. - GOC:mtg_apoptosis + + + down regulation of bile acid metabolic process + GOC:TermGenie + + + + + down regulation of bile acid metabolism + GOC:TermGenie + + + + + down-regulation of bile acid metabolic process + GOC:TermGenie + + + + + down-regulation of bile acid metabolism + GOC:TermGenie + + + + + downregulation of bile acid metabolic process + GOC:TermGenie + + + + + downregulation of bile acid metabolism + GOC:TermGenie - + - negative regulation of apoptotic signalling pathway - GOC:mah + negative regulation of bile acid metabolism + GOC:TermGenie + + + + + inhibition of bile acid metabolic process + GOC:TermGenie + + + + + inhibition of bile acid metabolism + GOC:TermGenie - + - + - + - - - - - - - - - + + + + - + - Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. - pr - 2011-11-24T01:20:58Z - positive regulation of apoptotic signalling pathway + Any process that activates or increases the frequency, rate or extent of bile acid metabolic process. + bf + 2015-05-20T11:04:40Z + positive regulation of bile acid metabolism + up regulation of bile acid metabolic process + up regulation of bile acid metabolism + up-regulation of bile acid metabolic process + up-regulation of bile acid metabolism + upregulation of bile acid metabolic process + upregulation of bile acid metabolism + activation of bile acid metabolic process + activation of bile acid metabolism biological_process - GO:2001235 - positive regulation of apoptotic signaling pathway + GO:1904253 + positive regulation of bile acid metabolic process - - - - - - - - - https://github.com/geneontology/go-ontology/issues/13926 + + + Any process that activates or increases the frequency, rate or extent of bile acid metabolic process. + GOC:TermGenie + GOC:bf + GO_REF:0000058 - - - Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. - GOC:mtg_apoptosis + + + positive regulation of bile acid metabolism + GOC:TermGenie + + + + + up regulation of bile acid metabolic process + GOC:TermGenie + + + + + up regulation of bile acid metabolism + GOC:TermGenie + + + + + up-regulation of bile acid metabolic process + GOC:TermGenie + + + + + up-regulation of bile acid metabolism + GOC:TermGenie - + + + upregulation of bile acid metabolic process + GOC:TermGenie + + + - positive regulation of apoptotic signalling pathway - GOC:mah + upregulation of bile acid metabolism + GOC:TermGenie + + + + + activation of bile acid metabolic process + GOC:TermGenie + + + + + activation of bile acid metabolism + GOC:TermGenie - + - + - + - - + + - + - Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. - yaf - 2011-12-02T02:01:20Z - negative regulation of chromosome organisation + Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. + mec + 2016-02-05T09:59:24Z + down regulation of establishment of protein localisation + down regulation of establishment of protein localization + down regulation of protein positioning + down regulation of protein recruitment + down-regulation of establishment of protein localisation + down-regulation of establishment of protein localization + down-regulation of protein positioning + down-regulation of protein recruitment + downregulation of establishment of protein localisation + downregulation of establishment of protein localization + downregulation of protein positioning + downregulation of protein recruitment + negative regulation of establishment of protein localisation + negative regulation of protein positioning + negative regulation of protein recruitment + inhibition of establishment of protein localisation + inhibition of establishment of protein localization + inhibition of protein positioning + inhibition of protein recruitment biological_process - negative regulation of chromosome organization and biogenesis - negative regulation of maintenance of genome integrity - negative regulation of nuclear genome maintenance - GO:2001251 - negative regulation of chromosome organization + GO:1904950 + negative regulation of establishment of protein localization - + - Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. - GOC:obol + Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. + GOC:TermGenie + GO_REF:0000058 + PMID:22761445 - + - negative regulation of chromosome organisation - GOC:obol + down regulation of establishment of protein localisation + GOC:TermGenie - - - negative regulation of chromosome organization and biogenesis - GOC:obol + + + down regulation of establishment of protein localization + GOC:TermGenie - - - negative regulation of maintenance of genome integrity - GOC:obol + + + down regulation of protein positioning + GOC:TermGenie - - - negative regulation of nuclear genome maintenance - GOC:obol + + + down regulation of protein recruitment + GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of chromosome organization. - yaf - 2011-12-02T02:01:26Z - positive regulation of chromosome organisation - biological_process - positive regulation of chromosome organization and biogenesis - positive regulation of maintenance of genome integrity - positive regulation of nuclear genome maintenance - GO:2001252 - positive regulation of chromosome organization - - - - Any process that activates or increases the frequency, rate or extent of chromosome organization. - GOC:obol + + + down-regulation of establishment of protein localisation + GOC:TermGenie - + - positive regulation of chromosome organisation - GOC:obol + down-regulation of establishment of protein localization + GOC:TermGenie - - - positive regulation of chromosome organization and biogenesis - GOC:obol + + + down-regulation of protein positioning + GOC:TermGenie - - - positive regulation of maintenance of genome integrity - GOC:obol + + + down-regulation of protein recruitment + GOC:TermGenie - - - positive regulation of nuclear genome maintenance - GOC:obol + + + downregulation of establishment of protein localisation + GOC:TermGenie + + + + + downregulation of establishment of protein localization + GOC:TermGenie + + + + + downregulation of protein positioning + GOC:TermGenie + + + + + downregulation of protein recruitment + GOC:TermGenie + + + + + negative regulation of establishment of protein localisation + GOC:TermGenie + + + + + negative regulation of protein positioning + GOC:TermGenie + + + + + negative regulation of protein recruitment + GOC:TermGenie + + + + + inhibition of establishment of protein localisation + GOC:TermGenie + + + + + inhibition of establishment of protein localization + GOC:TermGenie + + + + + inhibition of protein positioning + GOC:TermGenie + + + + + inhibition of protein recruitment + GOC:TermGenie - - - - - data item - data item - - - - - - - - - information content entity - information content entity - - - - - - - - - - - - - - - - - - - - - - - - curation status specification - - The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value. - Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting) - PERSON:Bill Bug - GROUP:OBI:<http://purl.obolibrary.org/obo/obi> - OBI_0000266 - curation status specification - - - - - - - - - data about an ontology part - Data about an ontology part is a data item about a part of an ontology, for example a term - Person:Alan Ruttenberg - data about an ontology part - - - - - - - - - - - - - - - - - - - - - obsolescence reason specification - - The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value. - The creation of this class has been inspired in part by Werner Ceusters' paper, Applying evolutionary terminology auditing to the Gene Ontology. - PERSON: Alan Ruttenberg - PERSON: Melanie Courtot - obsolescence reason specification - - - - - + - + - - - - - + + + + + + + - - denotator type - The Basic Formal Ontology ontology makes a distinction between Universals and defined classes, where the formal are "natural kinds" and the latter arbitrary collections of entities. - A denotator type indicates how a term should be interpreted from an ontological perspective. - Alan Ruttenberg - Barry Smith, Werner Ceusters - denotator type - - - - - - - - - A change of place or position of part of an organism that does not involve the entire organism [NBO:SMAC] - 2011-04-14T01:03:39Z - George Gkoutos - stationary movement - behavior_ontology - body part movement - - - - - - - - - The act of moving any of the tissues and hard structures surrounding the mouth other than teeth, jaws or filter structures [NBO:AC] - 2011-04-14T01:03:39Z - George Gkoutos - mouth part movement - other moved mouth parts - behavior_ontology - mouth movement - - - - - - - - - The act of repeated grinding, tearing, and or crushing with teeth or jaws [NBO:SMAC] - 2011-04-14T01:20:02Z - George Gkoutos - chew - gnaw - mastication - behavior_ontology - chewing - - - - - - - - - "The action, reaction, or performance of an organism in response to external or internal stimuli." [GO:GO\:0007610] - 2011-04-05T09:53:10Z - George Gkoutos - NBO:0000000 - behavior - behaviour - behavior_ontology - GO:0007610 - behavior process - - - - - - - - - "Movement behavior of the body or its parts." - 2011-04-05T02:08:47Z - George Gkoutos - behavior_ontology - kinesthetic behavior - - - - - - - - - 2012-03-17T09:51:17Z - gkoutos - behavior_ontology - jaw movement - - - - - - - - - - - - - - + + - - + + - "Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli." [GO:0050795] - George Gkoutos - GO:0050795 - regulation of behavior - - - - - - - - - - GC_ID:1 - PMID:15371245 - ncbi_taxonomy - NCBITaxon:10066 - Muridae - - - - - - - - - - GC_ID:1 - Mus - mice - mouse - ncbi_taxonomy - NCBITaxon:10088 - Mus <genus> + Any process that activates or increases the frequency, rate or extent of establishment of protein localization. + mec + 2016-02-05T09:59:32Z + positive regulation of establishment of protein localisation + positive regulation of protein positioning + positive regulation of protein recruitment + up regulation of establishment of protein localisation + up regulation of establishment of protein localization + up regulation of protein positioning + up regulation of protein recruitment + up-regulation of establishment of protein localisation + up-regulation of establishment of protein localization + up-regulation of protein positioning + up-regulation of protein recruitment + upregulation of establishment of protein localisation + upregulation of establishment of protein localization + upregulation of protein positioning + upregulation of protein recruitment + activation of establishment of protein localisation + activation of establishment of protein localization + activation of protein positioning + activation of protein recruitment + biological_process + GO:1904951 + positive regulation of establishment of protein localization - - - Mus - - - - - - mice - + + + Any process that activates or increases the frequency, rate or extent of establishment of protein localization. + GOC:TermGenie + GO_REF:0000058 + PMID:22761445 - + - mouse - + positive regulation of establishment of protein localisation + GOC:TermGenie - - - - - - - - - NCBITaxon:85055 - GC_ID:1 - house mouse - mouse - ncbi_taxonomy - NCBITaxon:10090 - Mus musculus - - + - house mouse - + positive regulation of protein positioning + GOC:TermGenie - + - mouse - + positive regulation of protein recruitment + GOC:TermGenie - - - - - - - - - GC_ID:1 - rat - rats - ncbi_taxonomy - NCBITaxon:10114 - Rattus - - + - rat - + up regulation of establishment of protein localisation + GOC:TermGenie - + - rats - + up regulation of establishment of protein localization + GOC:TermGenie - - - - - - - - - GC_ID:1 - ncbi_taxonomy - Palpata - NCBITaxon:105389 - Sedentaria - - - - Palpata - - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:105391 - Canalipalpata - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:110814 - Xenoturbellida - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:110815 - Xenoturbella - - - - - - - - - - GC_ID:1 - fish - fishes - ncbi_taxonomy - Agnatha - Hyperotreti - NCBITaxon:117565 - Myxini - + + + up regulation of protein positioning + GOC:TermGenie + - + - fish - + up regulation of protein recruitment + GOC:TermGenie - + - fishes - + up-regulation of establishment of protein localisation + GOC:TermGenie - - - Agnatha - + + + up-regulation of establishment of protein localization + GOC:TermGenie - - - Hyperotreti - + + + up-regulation of protein positioning + GOC:TermGenie - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:117570 - Teleostomi - - - - - - - - - - NCBITaxon:40673 - GC_ID:1 - bony vertebrates - ncbi_taxonomy - NCBITaxon:117571 - Euteleostomi - - + - bony vertebrates - + up-regulation of protein recruitment + GOC:TermGenie - - - - - - - - - NCBITaxon:27837 - GC_ID:1 - ncbi_taxonomy - Adenophorea - NCBITaxon:119089 - Chromadorea - - - - Adenophorea - + + + upregulation of establishment of protein localisation + GOC:TermGenie - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:1206794 - Ecdysozoa - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:1206795 - Lophotrochozoa - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:123365 - Neoteleostei - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - Eurypterygii - NCBITaxon:123366 - Eurypterygia - - - - Eurypterygii - + + + upregulation of establishment of protein localization + GOC:TermGenie - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:123367 - Ctenosquamata - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - Acanthomorpha - NCBITaxon:123368 - Acanthomorphata - - - - Acanthomorpha - + + + upregulation of protein positioning + GOC:TermGenie - - - - - - - - - GC_ID:1 - ncbi_taxonomy - Euacanthomorpha - NCBITaxon:123369 - Euacanthomorphacea - - - - Euacanthomorpha - + + + upregulation of protein recruitment + GOC:TermGenie + + + + + activation of establishment of protein localisation + GOC:TermGenie + + + + + activation of establishment of protein localization + GOC:TermGenie + + + + + activation of protein positioning + GOC:TermGenie + + + + + activation of protein recruitment + GOC:TermGenie - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:124129 - Acipenserinae - - - - - + - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:124130 - Acipenserini + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of epithelial tube formation. + bhm + 2016-06-20T09:35:41Z + biological_process + GO:1905276 + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). + regulation of epithelial tube formation + + + + Any process that modulates the frequency, rate or extent of epithelial tube formation. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + - + - - - - GC_ID:1 - gamophytes - ncbi_taxonomy - Conjugatophyceae - Gamophyceae - Gamophyta - Zygnematophyceae - NCBITaxon:131209 - Zygnemophyceae + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation. + bhm + 2016-06-20T09:35:49Z + down regulation of epithelial tube formation + down-regulation of epithelial tube formation + downregulation of epithelial tube formation + inhibition of epithelial tube formation + biological_process + GO:1905277 + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). + negative regulation of epithelial tube formation - - - gamophytes - + + + Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 - - - Conjugatophyceae - + + + down regulation of epithelial tube formation + GOC:TermGenie - - - Gamophyceae - + + + down-regulation of epithelial tube formation + GOC:TermGenie - - - Gamophyta - + + + downregulation of epithelial tube formation + GOC:TermGenie - - - Zygnematophyceae - + + + inhibition of epithelial tube formation + GOC:TermGenie - + - - - - GC_ID:1 - charophyte/embryophyte group - ncbi_taxonomy - Charophyta/Embryophyta group - NCBITaxon:131221 - Streptophytina + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of epithelial tube formation. + bhm + 2016-06-20T09:35:57Z + up regulation of epithelial tube formation + up-regulation of epithelial tube formation + upregulation of epithelial tube formation + activation of epithelial tube formation + biological_process + GO:1905278 + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). + positive regulation of epithelial tube formation - + + + Any process that activates or increases the frequency, rate or extent of epithelial tube formation. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + + + + + up regulation of epithelial tube formation + GOC:TermGenie + + + - charophyte/embryophyte group - + up-regulation of epithelial tube formation + GOC:TermGenie - - - Charophyta/Embryophyta group - + + + upregulation of epithelial tube formation + GOC:TermGenie - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:1312402 - Xenacoelomorpha - - - - - - - - GC_ID:1 - ncbi_taxonomy - biota - NCBITaxon:131567 - cellular organisms - - - - biota - + + + activation of epithelial tube formation + GOC:TermGenie - + - - - - GC_ID:1 - PMID:22839753 - PMID:25450099 - ncbi_taxonomy - Archosauria-Testudines - Testudines + Archosauria group - NCBITaxon:1329799 - Archelosauria + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. + bhm + 2016-07-22T07:13:49Z + regulation of epithelium morphogenesis + biological_process + GO:1905330 + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). + regulation of morphogenesis of an epithelium - - - Archosauria-Testudines - + + + Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 - - - Testudines + Archosauria group - + + + regulation of epithelium morphogenesis + GOC:TermGenie - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:1338369 - Dipnotetrapodomorpha - - - - - + - - - - GC_ID:1 - PMID:11062127 - PMID:9342353 - ncbi_taxonomy - Eumycetozoa Zopf, 1884 - Mycetozoa - mycetozoans - NCBITaxon:142796 - Eumycetozoa + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. + bhm + 2016-07-22T07:13:57Z + down regulation of epithelium morphogenesis + down regulation of morphogenesis of an epithelium + down-regulation of epithelium morphogenesis + down-regulation of morphogenesis of an epithelium + downregulation of epithelium morphogenesis + downregulation of morphogenesis of an epithelium + negative regulation of epithelium morphogenesis + inhibition of epithelium morphogenesis + inhibition of morphogenesis of an epithelium + biological_process + GO:1905331 + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). + negative regulation of morphogenesis of an epithelium - - - Eumycetozoa Zopf, 1884 - + + + Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 - - - Mycetozoa - + + + down regulation of epithelium morphogenesis + GOC:TermGenie - - - mycetozoans - + + + down regulation of morphogenesis of an epithelium + GOC:TermGenie - - - - - - - - - GC_ID:1 - PMID:11743200 - PMID:11791233 - ncbi_taxonomy - Boreotheria - NCBITaxon:1437010 - Boreoeutheria - - - - Boreotheria - + + + down-regulation of epithelium morphogenesis + GOC:TermGenie - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:1437180 - Acrogymnospermae - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:1445966 - Gnetidae - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:147099 - Acoelomorpha - - - - - - - - - - GC_ID:1 - true yeasts - ncbi_taxonomy - NCBITaxon:147537 - Saccharomycotina - - + - true yeasts - + down-regulation of morphogenesis of an epithelium + GOC:TermGenie - - - - - - - - - GC_ID:1 - ncbi_taxonomy - Archiascomycota - NCBITaxon:147554 - Schizosaccharomycetes - - - - Archiascomycota - + + + downregulation of epithelium morphogenesis + GOC:TermGenie - - - - - - - - - GC_ID:1 - jawless vertebrates - ncbi_taxonomy - Agnatha - NCBITaxon:1476529 - Cyclostomata - - + - jawless vertebrates - + downregulation of morphogenesis of an epithelium + GOC:TermGenie - - - Agnatha - + + + negative regulation of epithelium morphogenesis + GOC:TermGenie - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:1489341 - Osteoglossocephalai - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:1489388 - Euteleosteomorpha - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:1489872 - Percomorphaceae - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - Percomorpharia - NCBITaxon:1489922 - Eupercaria - - - - Percomorpharia - + + + inhibition of epithelium morphogenesis + GOC:TermGenie - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:1547233 - Xenoturbellidae - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:186622 - Acipenseroidei - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:186623 - Actinopteri - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:186625 - Clupeocephala - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - Otophysa - NCBITaxon:186626 - Otophysi - - - - Otophysa - + + + inhibition of morphogenesis of an epithelium + GOC:TermGenie - + - - - - GC_ID:1 - ncbi_taxonomy - Cypriniphysi - NCBITaxon:186627 - Cypriniphysae + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. + bhm + 2016-07-22T07:14:05Z + positive regulation of epithelium morphogenesis + up regulation of epithelium morphogenesis + up regulation of morphogenesis of an epithelium + up-regulation of epithelium morphogenesis + up-regulation of morphogenesis of an epithelium + upregulation of epithelium morphogenesis + upregulation of morphogenesis of an epithelium + activation of epithelium morphogenesis + activation of morphogenesis of an epithelium + biological_process + GO:1905332 + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). + positive regulation of morphogenesis of an epithelium - - - Cypriniphysi - + + + Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 - - - - - - - - - GC_ID:1 - ncbi_taxonomy - Ostarioclupeomorpha - Otocephala - NCBITaxon:186634 - Otomorpha - - - - Ostarioclupeomorpha - + + + positive regulation of epithelium morphogenesis + GOC:TermGenie - - - Otocephala - + + + up regulation of epithelium morphogenesis + GOC:TermGenie - - - - - - - - - GC_ID:1 - mice and others - ncbi_taxonomy - Sciurognathi - NCBITaxon:1963758 - Myomorpha - - + - mice and others - + up regulation of morphogenesis of an epithelium + GOC:TermGenie - - - Sciurognathi - + + + up-regulation of epithelium morphogenesis + GOC:TermGenie + + + + + up-regulation of morphogenesis of an epithelium + GOC:TermGenie + + + + + upregulation of epithelium morphogenesis + GOC:TermGenie + + + + + upregulation of morphogenesis of an epithelium + GOC:TermGenie + + + + + activation of epithelium morphogenesis + GOC:TermGenie + + + + + activation of morphogenesis of an epithelium + GOC:TermGenie - - - - - - GC_ID:1 - PMID:10874751 - PMID:11557979 - ncbi_taxonomy - NCBITaxon:197562 - Pancrustacea - - - - - + - - - - GC_ID:1 - PMID:11557979 - PMID:9727836 - mandibulates - ncbi_taxonomy - NCBITaxon:197563 - Mandibulata + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of blood vessel branching. + nc + 2016-10-12T14:19:33Z + regulation of branching involved in blood vessel morphogenesis + biological_process + GO:1905553 + regulation of blood vessel branching - + + + Any process that modulates the frequency, rate or extent of blood vessel branching. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + + + - mandibulates - + regulation of branching involved in blood vessel morphogenesis + GOC:TermGenie - + - - - - GC_ID:11 - PMID:10425795 - PMID:10425796 - PMID:10425797 - PMID:10490293 - PMID:10843050 - PMID:10939651 - PMID:10939673 - PMID:10939677 - PMID:11211268 - PMID:11321083 - PMID:11321113 - PMID:11411719 - PMID:11540071 - PMID:11542017 - PMID:11542087 - PMID:11760965 - PMID:12054223 - PMID:2112744 - PMID:270744 - PMID:32628106 - PMID:36748408 - PMID:7520741 - PMID:8123559 - PMID:8186100 - PMID:8590690 - PMID:9103655 - PMID:9336922 - eubacteria - ncbi_taxonomy - Monera - Procaryotae - Prokaryota - Prokaryotae - bacteria - prokaryote - prokaryotes - NCBITaxon:2 - Bacteria + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching. + nc + 2016-10-12T14:19:41Z + down regulation of branching involved in blood vessel morphogenesis + down regulation of patterning of blood vessels + down-regulation of branching involved in blood vessel morphogenesis + down-regulation of patterning of blood vessels + downregulation of branching involved in blood vessel morphogenesis + downregulation of patterning of blood vessels + negative regulation of branching involved in blood vessel morphogenesis + inhibition of branching involved in blood vessel morphogenesis + inhibition of patterning of blood vessels + biological_process + GO:1905554 + negative regulation of vessel branching - + + + Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + + + - eubacteria - + down regulation of branching involved in blood vessel morphogenesis + GOC:TermGenie - - - Monera - + + + down regulation of patterning of blood vessels + GOC:TermGenie - - - Procaryotae - + + + down-regulation of branching involved in blood vessel morphogenesis + GOC:TermGenie - - - Prokaryota - + + + down-regulation of patterning of blood vessels + GOC:TermGenie - - - Prokaryotae - + + + downregulation of branching involved in blood vessel morphogenesis + GOC:TermGenie - - - bacteria - + + + downregulation of patterning of blood vessels + GOC:TermGenie - - - prokaryote - + + + negative regulation of branching involved in blood vessel morphogenesis + GOC:TermGenie - - - prokaryotes - + + + inhibition of branching involved in blood vessel morphogenesis + GOC:TermGenie - - - - - - - - - GC_ID:1 - PMID:29367151 - ncbi_taxonomy - NCBITaxon:2058185 - Dictyosteliaceae - - - - - - - - - - GC_ID:1 - PMID:29367151 - ncbi_taxonomy - NCBITaxon:2058949 - Dictyosteliales - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - Homo/Pan/Gorilla group - NCBITaxon:207598 - Homininae - - - - Homo/Pan/Gorilla group - + + + inhibition of patterning of blood vessels + GOC:TermGenie - + - - - - GC_ID:11 - PMID:10425795 - PMID:10425796 - PMID:10425797 - PMID:10490293 - PMID:10843050 - PMID:10939651 - PMID:10939673 - PMID:10939677 - PMID:11211268 - PMID:11321083 - PMID:11321113 - PMID:11411719 - PMID:11540071 - PMID:11541975 - PMID:11542064 - PMID:11542149 - PMID:11760965 - PMID:12054223 - PMID:2112744 - PMID:25527841 - PMID:270744 - PMID:32628106 - PMID:36748408 - PMID:8123559 - PMID:8590690 - PMID:9103655 - PMID:9336922 - ncbi_taxonomy - Archaebacteria - Mendosicutes - Metabacteria - Monera - Procaryotae - Prokaryota - Prokaryotae - archaea - prokaryote - prokaryotes - NCBITaxon:2157 - Archaea + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of blood vessel branching. + nc + 2016-10-12T14:19:49Z + positive regulation of branching involved in blood vessel morphogenesis + up regulation of branching involved in blood vessel morphogenesis + up regulation of patterning of blood vessels + up-regulation of branching involved in blood vessel morphogenesis + up-regulation of patterning of blood vessels + upregulation of branching involved in blood vessel morphogenesis + upregulation of patterning of blood vessels + activation of branching involved in blood vessel morphogenesis + activation of patterning of blood vessels + biological_process + GO:1905555 + positive regulation of blood vessel branching - - - Archaebacteria - + + + Any process that activates or increases the frequency, rate or extent of blood vessel branching. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 - - - Mendosicutes - + + + positive regulation of branching involved in blood vessel morphogenesis + GOC:TermGenie - - - Metabacteria - + + + up regulation of branching involved in blood vessel morphogenesis + GOC:TermGenie - - - Monera - + + + up regulation of patterning of blood vessels + GOC:TermGenie - - - Procaryotae - + + + up-regulation of branching involved in blood vessel morphogenesis + GOC:TermGenie - - - Prokaryota - + + + up-regulation of patterning of blood vessels + GOC:TermGenie - - - Prokaryotae - + + + upregulation of branching involved in blood vessel morphogenesis + GOC:TermGenie - - - archaea - + + + upregulation of patterning of blood vessels + GOC:TermGenie - - - prokaryote - + + + activation of branching involved in blood vessel morphogenesis + GOC:TermGenie - - - prokaryotes - + + + activation of patterning of blood vessels + GOC:TermGenie - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:2301116 - Rhabditina - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:2301119 - Rhabditomorpha - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:2605435 - Evosea - - - - - + - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:2611352 - Discoba + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of mesoderm formation. + rph + 2017-02-03T12:28:20Z + biological_process + GO:1905902 + regulation of mesoderm formation + + + + Any process that modulates the frequency, rate or extent of mesoderm formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23939491 + - + - - - - GC_ID:1 - Xenopus - ncbi_taxonomy - NCBITaxon:262014 - Xenopus <subgenus> + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation. + rph + 2017-02-03T12:28:29Z + down regulation of mesoderm formation + down-regulation of mesoderm formation + downregulation of mesoderm formation + inhibition of mesoderm formation + biological_process + GO:1905903 + negative regulation of mesoderm formation - + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23939491 + + + - Xenopus - + down regulation of mesoderm formation + GOC:TermGenie - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:2684882 - Zygnematophycidae - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:2697495 - Spiralia - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - SAR supergroup - NCBITaxon:2698737 - Sar - - - - SAR supergroup - + + + down-regulation of mesoderm formation + GOC:TermGenie + + + + + downregulation of mesoderm formation + GOC:TermGenie + + + + + inhibition of mesoderm formation + GOC:TermGenie - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:2743709 - Danionidae - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:2743711 - Danioninae - - - - - + - - - - GC_ID:1 - PMID:23020233 - PMID:30257078 - eucaryotes - eukaryotes - ncbi_taxonomy - Eucarya - Eucaryotae - Eukarya - Eukaryotae - eukaryotes - NCBITaxon:2759 - Eukaryota + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of mesoderm formation. + rph + 2017-02-03T12:28:38Z + up regulation of mesoderm formation + up-regulation of mesoderm formation + upregulation of mesoderm formation + activation of mesoderm formation + biological_process + GO:1905904 + positive regulation of mesoderm formation - - - eucaryotes - + + + Any process that activates or increases the frequency, rate or extent of mesoderm formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23939491 - + - eukaryotes - - - - - - Eucarya - - - - - - Eucaryotae - + up regulation of mesoderm formation + GOC:TermGenie - - - Eukarya - + + + up-regulation of mesoderm formation + GOC:TermGenie - - - Eukaryotae - + + + upregulation of mesoderm formation + GOC:TermGenie - - - eukaryotes - + + + activation of mesoderm formation + GOC:TermGenie - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:30319 - Pipoidea - - - - - + - - - - GC_ID:1 - ncbi_taxonomy - Cyprinoidea - NCBITaxon:30727 - Cyprinoidei + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of lipid localization. + rz + 2017-02-21T12:12:22Z + regulation of lipid localisation + biological_process + GO:1905952 + regulation of lipid localization - - - Cyprinoidea - + + + Any process that modulates the frequency, rate or extent of lipid localization. + GOC:TermGenie + GO_REF:0000058 + PMID:17564681 - - - - - - - - - GC_ID:1 - pufferfishes and others - ncbi_taxonomy - NCBITaxon:31022 - Tetraodontiformes - - + - pufferfishes and others - + regulation of lipid localisation + GOC:TermGenie - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:31028 - Tetraodontoidei - - - - - + - - - - GC_ID:1 - puffer fishes - puffers - ncbi_taxonomy - NCBITaxon:31031 - Tetraodontidae + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. + rz + 2017-02-21T12:12:41Z + down regulation of lipid localisation + down regulation of lipid localization + down-regulation of lipid localisation + down-regulation of lipid localization + downregulation of lipid localisation + downregulation of lipid localization + negative regulation of lipid localisation + inhibition of lipid localisation + inhibition of lipid localization + biological_process + GO:1905953 + negative regulation of lipid localization - + + + Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. + GOC:TermGenie + GO_REF:0000058 + PMID:17564681 + + + - puffer fishes - + down regulation of lipid localisation + GOC:TermGenie - + - puffers - + down regulation of lipid localization + GOC:TermGenie - - - - - - - - - GC_ID:1 - ncbi_taxonomy - Fugu - NCBITaxon:31032 - Takifugu - - - - Fugu - + + + down-regulation of lipid localisation + GOC:TermGenie - - - - - - - - - GC_ID:1 - tiger puffer - torafugu - ncbi_taxonomy - Fugu rubripes - Sphaeroides rubripes - Tetraodon rubripes - NCBITaxon:31033 - Takifugu rubripes - - + - tiger puffer - + down-regulation of lipid localization + GOC:TermGenie - + - torafugu - + downregulation of lipid localisation + GOC:TermGenie - - - Fugu rubripes - + + + downregulation of lipid localization + GOC:TermGenie - - - Sphaeroides rubripes - + + + negative regulation of lipid localisation + GOC:TermGenie - - - Tetraodon rubripes - + + + inhibition of lipid localisation + GOC:TermGenie - - - - - - - - - GC_ID:1 - PMID:11214319 - PMID:12082125 - PMID:12878460 - PMID:15522813 - ncbi_taxonomy - NCBITaxon:314146 - Euarchontoglires - - - - - - - - - - GC_ID:1 - PMID:11214319 - PMID:12082125 - PMID:15522813 - Rodents and rabbits - ncbi_taxonomy - NCBITaxon:314147 - Glires - - - - Rodents and rabbits - + + + inhibition of lipid localization + GOC:TermGenie - + - - - - GC_ID:1 - ncbi_taxonomy - Anthropoidea - NCBITaxon:314293 - Simiiformes + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of lipid localization. + rz + 2017-02-21T12:12:49Z + positive regulation of lipid localisation + up regulation of lipid localisation + up regulation of lipid localization + up-regulation of lipid localisation + up-regulation of lipid localization + upregulation of lipid localisation + upregulation of lipid localization + activation of lipid localisation + activation of lipid localization + biological_process + GO:1905954 + positive regulation of lipid localization - - - Anthropoidea - + + + Any process that activates or increases the frequency, rate or extent of lipid localization. + GOC:TermGenie + GO_REF:0000058 + PMID:17564681 - - - - - - - - - GC_ID:1 - ape - apes - ncbi_taxonomy - NCBITaxon:314295 - Hominoidea - - + - ape - + positive regulation of lipid localisation + GOC:TermGenie - + - apes - + up regulation of lipid localisation + GOC:TermGenie - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:3176 - Zygnematales - - - - - - - - - - GC_ID:1 - higher plants - land plants - plants - ncbi_taxonomy - land plants - NCBITaxon:3193 - Embryophyta - - + - higher plants - + up regulation of lipid localization + GOC:TermGenie - + - land plants - + up-regulation of lipid localisation + GOC:TermGenie - + - plants - + up-regulation of lipid localization + GOC:TermGenie - - - land plants - + + + upregulation of lipid localisation + GOC:TermGenie - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:32341 - Sophophora - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:32346 - melanogaster group - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:32351 - melanogaster subgroup - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:32440 - Chondrostei - - - - - - - - - - GC_ID:1 - teleost fishes - ncbi_taxonomy - NCBITaxon:32443 - Teleostei - - + - teleost fishes - + upregulation of lipid localization + GOC:TermGenie - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:32517 - Tetradontoidea - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:32519 - Ostariophysi - - - - - - - - - - GC_ID:1 - tetrapods - ncbi_taxonomy - NCBITaxon:32523 - Tetrapoda - - - - tetrapods - + + + activation of lipid localisation + GOC:TermGenie - - - - - - - - - GC_ID:1 - amniotes - ncbi_taxonomy - NCBITaxon:32524 - Amniota - - - - amniotes - + + + activation of lipid localization + GOC:TermGenie - + - - - - GC_ID:1 - Theria - ncbi_taxonomy - NCBITaxon:32525 - Theria <mammals> + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of multicellular organismal development. + tb + 2010-08-05T11:25:59Z + biological_process + GO:2000026 + regulation of multicellular organismal development - - - Theria - + + + Any process that modulates the frequency, rate or extent of multicellular organismal development. + GOC:obol - + - - - - GC_ID:1 - diapsids - ncbi_taxonomy - Diapsida - NCBITaxon:32561 - Sauria + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process. + tb + 2010-09-15T08:55:45Z + regulation of cellular biopolymer biosynthetic process + regulation of cellular macromolecule anabolism + regulation of cellular macromolecule biosynthesis + regulation of cellular macromolecule formation + regulation of cellular macromolecule synthesis + biological_process + GO:2000112 + regulation of cellular macromolecule biosynthetic process - - - diapsids - - - - - - Diapsida - + + + Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process. + GOC:obol - - - - - - - - - GC_ID:1 - PMID:11062127 - PMID:29367151 - PMID:9342353 - dictyostelid cellular slime molds - ncbi_taxonomy - Dictyostelida - Dictyostelids - Dictyosteliida - cellular slime molds - NCBITaxon:33083 - Dictyostelia - - + - dictyostelid cellular slime molds - + regulation of cellular biopolymer biosynthetic process + GOC:obol - - - Dictyostelida - + + + regulation of cellular macromolecule anabolism + GOC:obol - - - Dictyostelids - + + + regulation of cellular macromolecule biosynthesis + GOC:obol - - - Dictyosteliida - + + + regulation of cellular macromolecule formation + GOC:obol - - - cellular slime molds - + + + regulation of cellular macromolecule synthesis + GOC:obol - + - - - - GC_ID:1 - PMID:16248873 - PMID:30257078 - Chlorophyta/Embryophyta group - chlorophyte/embryophyte group - green plants - ncbi_taxonomy - Chlorobionta - Chloroplastida - green plants - NCBITaxon:33090 - Viridiplantae + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process. + tb + 2010-09-15T08:55:48Z + negative regulation of cellular biopolymer biosynthetic process + negative regulation of cellular macromolecule anabolism + negative regulation of cellular macromolecule biosynthesis + negative regulation of cellular macromolecule formation + negative regulation of cellular macromolecule synthesis + biological_process + GO:2000113 + negative regulation of cellular macromolecule biosynthetic process - - - Chlorophyta/Embryophyta group - + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process. + GOC:obol - + - chlorophyte/embryophyte group - + negative regulation of cellular biopolymer biosynthetic process + GOC:obol - + - green plants - + negative regulation of cellular macromolecule anabolism + GOC:obol - - - Chlorobionta - + + + negative regulation of cellular macromolecule biosynthesis + GOC:obol - - - Chloroplastida - + + + negative regulation of cellular macromolecule formation + GOC:obol - - - green plants - + + + negative regulation of cellular macromolecule synthesis + GOC:obol - + - - - - GC_ID:1 - ncbi_taxonomy - conifers - NCBITaxon:3312 - Coniferophyta + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of cell motility. + mah + 2010-10-01T09:41:21Z + regulation of cell locomotion + regulation of movement of a cell + biological_process + regulation of cell movement + GO:2000145 + regulation of cell motility - - - conifers - + + + Any process that modulates the frequency, rate or extent of cell motility. + GOC:mah - - - - - - - - - GC_ID:1 - ncbi_taxonomy - Fungi/Metazoa group - opisthokonts - NCBITaxon:33154 - Opisthokonta - - - - Fungi/Metazoa group - + + + regulation of cell locomotion + GOC:obol - + + + regulation of movement of a cell + GOC:obol + + + - opisthokonts - + regulation of cell movement + GOC:obol - + - - - - GC_ID:1 - metazoans - multicellular animals - ncbi_taxonomy - Animalia - animals - NCBITaxon:33208 - Metazoa + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. + mah + 2010-10-01T09:41:26Z + negative regulation of cell locomotion + negative regulation of movement of a cell + biological_process + negative regulation of cell movement + GO:2000146 + negative regulation of cell motility - - - metazoans - + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. + GOC:mah - + - multicellular animals - + negative regulation of cell locomotion + GOC:obol - - - Animalia - + + + negative regulation of movement of a cell + GOC:obol - + - animals - + negative regulation of cell movement + GOC:obol - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:33213 - Bilateria - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:33317 - Protostomia - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:33340 - Neoptera - - - - - + - - - - GC_ID:1 - ncbi_taxonomy - Holometabola - NCBITaxon:33392 - Endopterygota + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of cell motility. + mah + 2010-10-01T09:41:30Z + positive regulation of cell locomotion + positive regulation of movement of a cell + biological_process + positive regulation of cell movement + GO:2000147 + positive regulation of cell motility - - - Holometabola - + + + Any process that activates or increases the frequency, rate or extent of cell motility. + GOC:mah - - - - - - - - - GC_ID:1 - deuterostomes - ncbi_taxonomy - NCBITaxon:33511 - Deuterostomia - - + - deuterostomes - + positive regulation of cell locomotion + GOC:obol - - - - - - - - - GC_ID:1 - alveolates - ncbi_taxonomy - NCBITaxon:33630 - Alveolata - - + - alveolates - + positive regulation of movement of a cell + GOC:obol - - - - - - - - - GC_ID:1 - ncbi_taxonomy - Euglenozoans - NCBITaxon:33682 - Euglenozoa - - + - Euglenozoans - + positive regulation of cell movement + GOC:obol - + - - - - GC_ID:1 - ncbi_taxonomy - Chlamydospermopsida - Gneticae - NCBITaxon:3372 - Gnetopsida + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis. + dph + 2010-10-13T12:46:31Z + biological_process + GO:2000181 + negative regulation of blood vessel morphogenesis - - - Chlamydospermopsida - - - - - - Gneticae - + + + Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis. + GOC:dph + GOC:yaf - - - - - - GC_ID:1 - PMID:15019624 - PMID:15371245 - ncbi_taxonomy - NCBITaxon:337687 - Muroidea - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:3378 - Gnetales - - - - - + - - - - GC_ID:1 - PMID:25249442 - angiosperms - flowering plants - ncbi_taxonomy - Angiospermae - Magnoliophyta - flowering plants - NCBITaxon:3398 - Magnoliopsida + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of reproductive process. + mah + 2010-11-10T02:44:02Z + biological_process + GO:2000241 + regulation of reproductive process - - - angiosperms - - - - - - flowering plants - - - - - - Angiospermae - - - - - - Magnoliophyta - - - - - - flowering plants - + + + Any process that modulates the frequency, rate or extent of reproductive process. + GOC:mah - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:34346 - Schizosaccharomycetales - - - - - + - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:35493 - Streptophyta + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. + mah + 2010-11-10T02:44:05Z + biological_process + GO:2000242 + negative regulation of reproductive process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. + GOC:mah + - + - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:376913 - Haplorrhini + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of reproductive process. + mah + 2010-11-10T02:44:08Z + biological_process + GO:2000243 + positive regulation of reproductive process + + + + Any process that activates or increases the frequency, rate or extent of reproductive process. + GOC:mah + - + - - - - GC_ID:1 - glaucocystophytes - ncbi_taxonomy - Glaucophyceae - Glaucophyta - algae - NCBITaxon:38254 - Glaucocystophyceae + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of defecation. + bf + 2010-12-21T09:23:08Z + biological_process + GO:2000292 + regulation of defecation - - - glaucocystophytes - - - - - - Glaucophyceae - - - - - - Glaucophyta - - - - - - algae - + + + Any process that modulates the frequency, rate or extent of defecation. + GOC:obol - + - - - - NCBITaxon:109679 - GC_ID:1 - ncbi_taxonomy - NCBITaxon:39107 - Murinae + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of defecation. + bf + 2010-12-21T09:23:13Z + biological_process + GO:2000293 + negative regulation of defecation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of defecation. + GOC:obol + - + - - - - GC_ID:1 - mammals - ncbi_taxonomy - mammals - NCBITaxon:40674 - Mammalia + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of defecation. + bf + 2010-12-21T09:23:16Z + biological_process + GO:2000294 + positive regulation of defecation - - - mammals - - - - - - mammals - + + + Any process that activates or increases the frequency, rate or extent of defecation. + GOC:obol - + - - - - NCBITaxon:167797 - NCBITaxon:27906 - NCBITaxon:29174 - NCBITaxon:41329 - NCBITaxon:54122 - NCBITaxon:55674 - NCBITaxon:55678 - NCBITaxon:6422 - GC_ID:1 - pogonophores - vestimentiferans - ncbi_taxonomy - Frenulata - Lamellibrachiidae - Obturata - Oligobrachiidae - Perviata - Pogonophora - Polybrachiidae - Sclerolinidae - Vestimentifera - tube worms - NCBITaxon:41324 - Siboglinidae + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of mesoderm development. + vk + 2011-02-15T03:09:46Z + biological_process + GO:2000380 + regulation of mesoderm development - - - pogonophores - - - - - - vestimentiferans - - - - - - Frenulata - - - - - - Lamellibrachiidae - - - - - - Obturata - - - - - - Oligobrachiidae - - - - - - Perviata - - - - - - Pogonophora - - - - - - Polybrachiidae - - - - - - Sclerolinidae - - - - - - Vestimentifera - - - - - - tube worms - + + + Any process that modulates the frequency, rate or extent of mesoderm development. + GOC:BHF - + - - - - GC_ID:1 - ncbi_taxonomy - Neopterygi - NCBITaxon:41665 - Neopterygii + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development. + vk + 2011-02-15T03:10:02Z + biological_process + GO:2000381 + negative regulation of mesoderm development - - - Neopterygi - + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development. + GOC:BHF - + - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:41666 - Batrachia + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of mesoderm development. + vk + 2011-02-15T03:10:12Z + biological_process + GO:2000382 + positive regulation of mesoderm development + + + + Any process that activates or increases the frequency, rate or extent of mesoderm development. + GOC:BHF + - + - - - - GC_ID:1 - dinosaur - dinosaurs - ncbi_taxonomy - NCBITaxon:436486 - Dinosauria + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of ectoderm development. + vk + 2011-02-15T03:17:10Z + biological_process + GO:2000383 + regulation of ectoderm development - - - dinosaur - - - - - - dinosaurs - + + + Any process that modulates the frequency, rate or extent of ectoderm development. + GOC:BHF - + - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:436489 - Saurischia + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development. + vk + 2011-02-15T03:17:27Z + biological_process + GO:2000384 + negative regulation of ectoderm development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development. + GOC:BHF + - + - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:436491 - Theropoda + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of ectoderm development. + vk + 2011-02-15T03:17:39Z + biological_process + GO:2000385 + positive regulation of ectoderm development + + + + Any process that activates or increases the frequency, rate or extent of ectoderm development. + GOC:BHF + - + - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:436492 - Coelurosauria + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation. + yaf + 2011-04-01T04:10:08Z + biological_process + GO:2000542 + negative regulation of gastrulation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation. + GOC:obol + - + - - - - NCBITaxon:43732 - GC_ID:1 - ncbi_taxonomy - Asilomorpha - NCBITaxon:43733 - Muscomorpha + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of gastrulation. + yaf + 2011-04-01T04:10:15Z + biological_process + GO:2000543 + positive regulation of gastrulation - - - Asilomorpha - + + + Any process that activates or increases the frequency, rate or extent of gastrulation. + GOC:obol - + - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:43738 - Schizophora + + + A change of place or position of part of an organism that does not involve the entire organism [NBO:SMAC] + 2011-04-14T01:03:39Z + George Gkoutos + stationary movement + behavior_ontology + body part movement - + - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:43741 - Acalyptratae + + + The act of moving any of the tissues and hard structures surrounding the mouth other than teeth, jaws or filter structures [NBO:AC] + 2011-04-14T01:03:39Z + George Gkoutos + mouth part movement + other moved mouth parts + behavior_ontology + mouth movement - + - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:43746 - Ephydroidea + + + The act of repeated grinding, tearing, and or crushing with teeth or jaws [NBO:SMAC] + 2011-04-14T01:20:02Z + George Gkoutos + chew + gnaw + mastication + behavior_ontology + chewing - + - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:43845 - Drosophilinae + + + "The action, reaction, or performance of an organism in response to external or internal stimuli." [GO:GO\:0007610] + 2011-04-05T09:53:10Z + George Gkoutos + NBO:0000000 + behavior + behaviour + behavior_ontology + GO:0007610 + behavior process - + - - - - GC_ID:1 - PMID:15689432 - PMID:16151185 - PMID:17010206 - PMID:17051209 - PMID:17572334 - ncbi_taxonomy - NCBITaxon:451864 - Dikarya + + + "Movement behavior of the body or its parts." + 2011-04-05T02:08:47Z + George Gkoutos + behavior_ontology + kinesthetic behavior - + - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:451866 - Taphrinomycotina + + + 2012-03-17T09:51:17Z + gkoutos + behavior_ontology + jaw movement - + - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:46877 - Drosophilini + + + + + + + + + + + + + + + "Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli." [GO:0050795] + George Gkoutos + GO:0050795 + regulation of behavior - + - - - + + GC_ID:1 - PMID:11062127 - PMID:12684019 ncbi_taxonomy - Mycota - fungi - NCBITaxon:4751 - Fungi + all + NCBITaxon:1 + root - + - Mycota + all - - - - fungi - - - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:480117 - Cyclorrhapha - - + - - - + + + GC_ID:1 + PMID:15371245 ncbi_taxonomy - NCBITaxon:480118 - Eremoneura + NCBITaxon:10066 + Muridae - + - - - + + + GC_ID:1 - PMID:17572334 - ascomycetes - sac fungi + rat + rats ncbi_taxonomy - ascomycete fungi - NCBITaxon:4890 - Ascomycota + NCBITaxon:10114 + Rattus - + - ascomycetes - + rat + - + - sac fungi + rats - - - - ascomycete fungi - - - + - - - - GC_ID:1 - ncbi_taxonomy - Hemiascomycetes - NCBITaxon:4891 - Saccharomycetes + + + Viruses - - - - Hemiascomycetes - - - + - - - + + + GC_ID:1 ncbi_taxonomy - Endomycetales - budding yeasts - NCBITaxon:4892 - Saccharomycetales + Palpata + NCBITaxon:105389 + Sedentaria - + - Endomycetales + Palpata - - - - budding yeasts - - - - - - - - NCBITaxon:221665 - NCBITaxon:44280 - GC_ID:1 - ncbi_taxonomy - NCBITaxon:4893 - Saccharomycetaceae - - - - - + - - - + + + GC_ID:1 - fission yeasts ncbi_taxonomy - Schizosaccharomycetoideae - NCBITaxon:4894 - Schizosaccharomycetaceae + NCBITaxon:105391 + Canalipalpata - - - - fission yeasts - - - - - - Schizosaccharomycetoideae - - - + - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:4895 - Schizosaccharomyces - + - + - - - - NCBITaxon:45042 + + + GC_ID:1 - fission yeast + fish + fishes ncbi_taxonomy - Schizosaccharomyces malidevorans - NCBITaxon:4896 - Schizosaccharomyces pombe + Agnatha + Hyperotreti + NCBITaxon:117565 + Myxini - + - fission yeast - + fish + + + + + + fishes + + + + + + Agnatha + - + - Schizosaccharomyces malidevorans + Hyperotreti - + - - - - NCBITaxon:36915 + + + GC_ID:1 ncbi_taxonomy - Pachytichospora - NCBITaxon:4930 - Saccharomyces + NCBITaxon:117570 + Teleostomi - - - - Pachytichospora - - - + - - - + + + + NCBITaxon:40673 GC_ID:1 - S. cerevisiae - baker's yeast - brewer's yeast + bony vertebrates ncbi_taxonomy - Candida robusta - Mycoderma cerevisiae - Saccharomyces capensis - Saccharomyces italicus - Saccharomyces oviformis - Saccharomyces uvarum var. melibiosus - NCBITaxon:4932 - Saccharomyces cerevisiae + NCBITaxon:117571 + Euteleostomi - - - S. cerevisiae - - - - + - baker's yeast + bony vertebrates - - - - brewer's yeast - - - - - - Candida robusta - - - - - - Mycoderma cerevisiae - - - - - - Saccharomyces capensis - - - - - - Saccharomyces italicus - - - - - - Saccharomyces oviformis - - - - - - Saccharomyces uvarum var. melibiosus - - - + - - + + + NCBITaxon:27837 GC_ID:1 - true insects ncbi_taxonomy - insects - NCBITaxon:50557 - Insecta + Adenophorea + NCBITaxon:119089 + Chromadorea - - - true insects - - - - + - insects - + Adenophorea + - + - - + + GC_ID:1 - PMID:23020233 - PMID:30257078 ncbi_taxonomy - NCBITaxon:554915 - Amoebozoa + NCBITaxon:1206794 + Ecdysozoa - + - - - + + + GC_ID:1 ncbi_taxonomy - NCBITaxon:55879 - Rhabditoidea + NCBITaxon:1206795 + Lophotrochozoa - + - - - + + + GC_ID:1 ncbi_taxonomy - NCBITaxon:55885 - Peloderinae + NCBITaxon:123365 + Neoteleostei - + - - - + + + GC_ID:1 - PMID:29367151 ncbi_taxonomy - Hyalostilbum - NCBITaxon:5782 - Dictyostelium + Eurypterygii + NCBITaxon:123366 + Eurypterygia - + - Hyalostilbum + Eurypterygii - + - - + + GC_ID:1 - vascular plants ncbi_taxonomy - vascular plants - NCBITaxon:58023 - Tracheophyta + NCBITaxon:123367 + Ctenosquamata - - - - vascular plants - - - - - - vascular plants - - - + - - + + GC_ID:1 - seed plants ncbi_taxonomy - seed plants - NCBITaxon:58024 - Spermatophyta + Acanthomorpha + NCBITaxon:123368 + Acanthomorphata - - - seed plants - - - - + - seed plants - + Acanthomorpha + - + - - - + + + GC_ID:1 - sponges ncbi_taxonomy - Parazoa - sponges - NCBITaxon:6040 - Porifera + Euacanthomorpha + NCBITaxon:123369 + Euacanthomorphacea - - - sponges - - - - + - Parazoa + Euacanthomorpha - - - - sponges - - - + - - - + + + GC_ID:1 ncbi_taxonomy - NCBITaxon:6072 - Eumetazoa + NCBITaxon:124129 + Acipenserinae - + - - - + + + GC_ID:1 - cnidarians - coelenterates ncbi_taxonomy - Coelenterata - cnidarians - NCBITaxon:6073 - Cnidaria + NCBITaxon:124130 + Acipenserini - - - - cnidarians - - - - - - coelenterates - - - - - - Coelenterata - - - - - - cnidarians - - - + - - - + + GC_ID:1 - flatworm - flatworms ncbi_taxonomy - flatworms - NCBITaxon:6157 - Platyhelminthes + biota + NCBITaxon:131567 + cellular organisms - - - flatworm - - - - - - flatworms - - - - + - flatworms - + biota + - + - - - + + + GC_ID:1 - nematode - nematodes - roundworm - roundworms + PMID:22839753 + PMID:25450099 ncbi_taxonomy - Nemata - nematodes - NCBITaxon:6231 - Nematoda + Archosauria-Testudines + Testudines + Archosauria group + NCBITaxon:1329799 + Archelosauria - - - nematode - - - - - - nematodes - - - - - - roundworm - - - - - - roundworms - - - - + - Nemata + Archosauria-Testudines - + - nematodes - + Testudines + Archosauria group + - - - - - - NCBITaxon:33251 - GC_ID:1 - ncbi_taxonomy - NCBITaxon:6236 - Rhabditida - - - - - + - - - + + + GC_ID:1 ncbi_taxonomy - NCBITaxon:6237 - Caenorhabditis + NCBITaxon:1338369 + Dipnotetrapodomorpha - + - - - + + + GC_ID:1 + PMID:11743200 + PMID:11791233 ncbi_taxonomy - Rhabditis elegans - NCBITaxon:6239 - Caenorhabditis elegans + Boreotheria + NCBITaxon:1437010 + Boreoeutheria - + - Rhabditis elegans + Boreotheria - + - - - - NCBITaxon:54603 - GC_ID:1 - ncbi_taxonomy - NCBITaxon:6243 - Rhabditidae - + - + - - - - GC_ID:1 - annelid worms - ncbi_taxonomy - segmented worms - NCBITaxon:6340 - Annelida - - - - - annelid worms - - - - - - segmented worms - - + - + - - - + + + GC_ID:1 - polychaetes + jawless vertebrates ncbi_taxonomy - NCBITaxon:6341 - Polychaeta + Agnatha + NCBITaxon:1476529 + Cyclostomata - + - polychaetes + jawless vertebrates + + + + Agnatha + + - + - - - + + + GC_ID:1 ncbi_taxonomy - NCBITaxon:6362 - Sabellida + NCBITaxon:1489341 + Osteoglossocephalai - + - - - + + + GC_ID:1 - arthropods ncbi_taxonomy - arthropods - NCBITaxon:6656 - Arthropoda + NCBITaxon:1489388 + Euteleosteomorpha - - - - arthropods - - - - - - arthropods - - - + - - - + + + GC_ID:1 - insects ncbi_taxonomy - Atelocerata - Tracheata - Uniramia - hexapods - NCBITaxon:6960 - Hexapoda + NCBITaxon:1489872 + Percomorphaceae - - - - insects - - - - - - Atelocerata - - - - - - Tracheata - - - - - - Uniramia - - - - - - hexapods - - - + - - - + + + GC_ID:1 - flies ncbi_taxonomy - flies - NCBITaxon:7147 - Diptera + Percomorpharia + NCBITaxon:1489922 + Eupercaria - - - flies - - - - + - flies - + Percomorpharia + - + - - - + + + GC_ID:1 ncbi_taxonomy - NCBITaxon:716545 - saccharomyceta + NCBITaxon:186622 + Acipenseroidei - + - - - + + + GC_ID:1 ncbi_taxonomy - NCBITaxon:7203 - Brachycera + NCBITaxon:186623 + Actinopteri - + - - - + + GC_ID:1 - pomace flies ncbi_taxonomy - NCBITaxon:7214 - Drosophilidae + NCBITaxon:186625 + Clupeocephala - - - - pomace flies - - - + - - - - NCBITaxon:7326 + + + GC_ID:1 - Drosophila - fruit flies - fruit fly ncbi_taxonomy - NCBITaxon:7215 - Drosophila <flies,genus> + Otophysa + NCBITaxon:186626 + Otophysi - - - Drosophila - - - - - - fruit flies - - - - - - fruit fly - + + + Otophysa + - + - - - - NCBITaxon:2267365 + + + GC_ID:1 - fruit fly ncbi_taxonomy - Sophophora melanogaster - NCBITaxon:7227 - Drosophila melanogaster + Cypriniphysi + NCBITaxon:186627 + Cypriniphysae - - - fruit fly - - - - + - Sophophora melanogaster + Cypriniphysi - + - - - + + + GC_ID:1 - Pterygota - winged insects ncbi_taxonomy - NCBITaxon:7496 - Pterygota <insects> + Ostarioclupeomorpha + Otocephala + NCBITaxon:186634 + Otomorpha - - - Pterygota - + + + Ostarioclupeomorpha + - - - winged insects - + + + Otocephala + - + - - - + + + GC_ID:1 - chordates + mice and others ncbi_taxonomy - chordates - NCBITaxon:7711 - Chordata + Sciurognathi + NCBITaxon:1963758 + Myomorpha - + - chordates + mice and others - + - chordates - + Sciurognathi + - + - - - + + + GC_ID:1 - tunicates + PMID:10874751 + PMID:11557979 ncbi_taxonomy - Urochordata - tunicates - NCBITaxon:7712 - Tunicata + NCBITaxon:197562 + Pancrustacea - - - - tunicates - - - - - - Urochordata - - - - - - tunicates - - - + - - + + GC_ID:1 - Vertebrata - vertebrates + PMID:11557979 + PMID:9727836 + mandibulates ncbi_taxonomy - vertebrates - NCBITaxon:7742 - Vertebrata <vertebrates> + NCBITaxon:197563 + Mandibulata - - - Vertebrata - - - - + - vertebrates - - - - - - vertebrates - + mandibulates + - + - - - + + + + Bacteria + + + + + + + + + GC_ID:1 ncbi_taxonomy - Myxinoidea - hagfishes - NCBITaxon:7761 - Myxiniformes + Homo/Pan/Gorilla group + NCBITaxon:207598 + Homininae - + - Myxinoidea + Homo/Pan/Gorilla group - - - - hagfishes - - - + - - - + + + Archaea + + + + + + + + + GC_ID:1 - hagfishes ncbi_taxonomy - NCBITaxon:7762 - Myxinidae + NCBITaxon:2301116 + Rhabditina - - - - hagfishes - - - + - - - + + + GC_ID:1 - Gnathostomata - jawed vertebrates ncbi_taxonomy - NCBITaxon:7776 - Gnathostomata <vertebrates> + NCBITaxon:2301119 + Rhabditomorpha - - - - Gnathostomata - - - - - - jawed vertebrates - - - + - - - + + + GC_ID:1 - cartilaginous fishes - fish - fishes + Xenopus ncbi_taxonomy - cartilaginous fishes - NCBITaxon:7777 - Chondrichthyes + NCBITaxon:262014 + Xenopus <subgenus> - - - cartilaginous fishes - - - - - - fish - - - - + - fishes - - - - - - cartilaginous fishes - + Xenopus + - + - - + + GC_ID:1 - euphyllophytes ncbi_taxonomy - NCBITaxon:78536 - Euphyllophyta + NCBITaxon:2697495 + Spiralia - - - - euphyllophytes - - - + - - - + + + GC_ID:1 ncbi_taxonomy - NCBITaxon:7863 - Holocephali + NCBITaxon:2743709 + Danionidae - + - - - + + + GC_ID:1 - chimaeras ncbi_taxonomy - chimaeras - NCBITaxon:7864 - Chimaeriformes + NCBITaxon:2743711 + Danioninae - - - - chimaeras - - - - - - chimaeras - - - + - - - + + + + GC_ID:1 - dipnoans - fish - fishes - lungfishes + PMID:23020233 + PMID:30257078 + eucaryotes + eukaryotes ncbi_taxonomy - Choanichthyes - Dipneusti - Dipnoi - Osteichthyes - lungfishes - NCBITaxon:7878 - Dipnomorpha + Eucarya + Eucaryotae + Eukarya + Eukaryotae + euk- + eukaryotes + NCBITaxon:2759 + Eukaryota - - - dipnoans - - - - + - fish - + eucaryotes + - + - fishes + eukaryotes - - - lungfishes - + + + Eucarya + - + - Choanichthyes - + Eucaryotae + - + - Dipneusti + Eukarya - + - Dipnoi + Eukaryotae - + - Osteichthyes - + euk- + PRO:DAN + - + - lungfishes + eukaryotes - + - - - + + + GC_ID:1 - fish - fishes - ray-finned fishes ncbi_taxonomy - Actinopterygi - Osteichthyes - bony fishes - NCBITaxon:7898 - Actinopterygii + NCBITaxon:30319 + Pipoidea - - - - fish - - - - - - fishes - - - - - - ray-finned fishes - - - - - - Actinopterygi - - - - - - Osteichthyes - - - - - - bony fishes - - - + - - - + + + GC_ID:1 - sturgeons and paddlefish ncbi_taxonomy - NCBITaxon:7899 - Acipenseriformes + Cyprinoidea + NCBITaxon:30727 + Cyprinoidei - - - sturgeons and paddlefish - + + + Cyprinoidea + - + - - - + + + GC_ID:1 - sturgeons + pufferfishes and others ncbi_taxonomy - NCBITaxon:7900 - Acipenseridae + NCBITaxon:31022 + Tetraodontiformes - + - sturgeons + pufferfishes and others - + - - - + + + GC_ID:1 ncbi_taxonomy - NCBITaxon:7901 - Acipenser + NCBITaxon:31028 + Tetraodontoidei - + - - - + + + GC_ID:1 - carps and others + puffer fishes + puffers ncbi_taxonomy - NCBITaxon:7952 - Cypriniformes + NCBITaxon:31031 + Tetraodontidae - + - carps and others + puffer fishes + + + + + + puffers - + - - + + - NCBITaxon:46777 - NCBITaxon:487617 GC_ID:1 ncbi_taxonomy - Brachydanio - Celestichthys - NCBITaxon:7954 - Danio + Fugu + NCBITaxon:31032 + Takifugu - - - Brachydanio - - - - + - Celestichthys + Fugu - + - - + + - NCBITaxon:27702 - NCBITaxon:37966 GC_ID:1 - leopard danio - zebra danio - zebra fish - zebrafish + tiger puffer + torafugu ncbi_taxonomy - Brachydanio rerio - Brachydanio rerio frankei - Cyprinus rerio - Danio frankei - Danio rerio frankei - NCBITaxon:7955 - Danio rerio + Fugu rubripes + Sphaeroides rubripes + Tetraodon rubripes + NCBITaxon:31033 + Takifugu rubripes - - - leopard danio - - - - - - zebra danio - - - - + - zebra fish + tiger puffer - + - zebrafish + torafugu - - - Brachydanio rerio - - - - - - Brachydanio rerio frankei - - - - + - Cyprinus rerio + Fugu rubripes - + - Danio frankei + Sphaeroides rubripes - + - Danio rerio frankei + Tetraodon rubripes - + - - - + + + GC_ID:1 + PMID:11214319 + PMID:12082125 + PMID:12878460 + PMID:15522813 ncbi_taxonomy - NCBITaxon:8287 - Sarcopterygii + NCBITaxon:314146 + Euarchontoglires - + - - - + + + GC_ID:1 - amphibians + PMID:11214319 + PMID:12082125 + PMID:15522813 + Rodents and rabbits ncbi_taxonomy - amphibians - NCBITaxon:8292 - Amphibia + NCBITaxon:314147 + Glires - + - amphibians + Rodents and rabbits - - - - amphibians - - - + - - - + + + GC_ID:1 - anurans - frogs - frogs and toads ncbi_taxonomy - Salientia - frogs & toads - NCBITaxon:8342 - Anura + Anthropoidea + NCBITaxon:314293 + Simiiformes - - - anurans - - - - - - frogs - - - - - - frogs and toads - - - - + - Salientia + Anthropoidea - - - - frogs & toads - - - + - - - + + + GC_ID:1 - PMID:2385174 - pipid frogs - tongueless frogs + ape + apes ncbi_taxonomy - NCBITaxon:8352 - Pipidae + NCBITaxon:314295 + Hominoidea - + - pipid frogs + ape - + - tongueless frogs + apes - + - - - + + + GC_ID:1 - PMID:2385174 - Xenopus ncbi_taxonomy - NCBITaxon:8353 - Xenopus <genus> + NCBITaxon:32341 + Sophophora - - - - Xenopus - - - + - - - + + + GC_ID:1 - African clawed frog - clawed frog - common platanna - platanna ncbi_taxonomy - Bufo laevis - NCBITaxon:8355 - Xenopus laevis + NCBITaxon:32346 + melanogaster group - - - - African clawed frog - - - - - - clawed frog - - - - - - common platanna - - - - - - platanna - - - - - - Bufo laevis - - - + - - - + + + GC_ID:1 - PMID:2385174 ncbi_taxonomy - Siluraninae - NCBITaxon:8360 - Xenopodinae + NCBITaxon:32351 + melanogaster subgroup - - - - Siluraninae - - - + - - - + + + GC_ID:1 - sauropsids ncbi_taxonomy - NCBITaxon:8457 - Sauropsida + NCBITaxon:32440 + Chondrostei + + + + + + + + + + GC_ID:1 + teleost fishes + ncbi_taxonomy + NCBITaxon:32443 + Teleostei - + - sauropsids + teleost fishes - + - - - + + + GC_ID:1 ncbi_taxonomy - NCBITaxon:8492 - Archosauria + NCBITaxon:32517 + Tetradontoidea - + - - - + + + GC_ID:1 ncbi_taxonomy - NCBITaxon:85512 - Dicondylia + NCBITaxon:32519 + Ostariophysi - + - - - + + + GC_ID:1 - Mus + tetrapods ncbi_taxonomy - NCBITaxon:862507 - Mus <subgenus> + NCBITaxon:32523 + Tetrapoda - + - Mus - + tetrapods + - + - - - + + + GC_ID:1 - birds + amniotes ncbi_taxonomy - avian - birds - NCBITaxon:8782 - Aves + NCBITaxon:32524 + Amniota - + - birds + amniotes - - - - avian - - - - - - birds - - - + - - - + + + GC_ID:1 + Theria ncbi_taxonomy - NCBITaxon:8783 - Palaeognathae + NCBITaxon:32525 + Theria <mammals> + + + + Theria + + - + - - - + + + GC_ID:1 - ostriches + diapsids ncbi_taxonomy - NCBITaxon:8798 - Struthioniformes + Diapsida + NCBITaxon:32561 + Sauria - + - ostriches + diapsids + + + + Diapsida + + - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:8799 - Struthionidae - - - - - + - - - + + + GC_ID:1 ncbi_taxonomy - NCBITaxon:8800 - Struthio + Fungi/Metazoa group + opisthokonts + NCBITaxon:33154 + Opisthokonta + + + + Fungi/Metazoa group + + + + + + opisthokonts + + - + - - - + + + GC_ID:1 - African ostrich - ostrich + metazoans + multicellular animals ncbi_taxonomy - Struthio camelus domesticus - NCBITaxon:8801 - Struthio camelus + Animalia + animals + metazoan- + NCBITaxon:33208 + Metazoa - + - African ostrich + metazoans - + - ostrich + multicellular animals - + - Struthio camelus domesticus + Animalia + + + + animals + + + + + + metazoan- + PRO:DAN + + - + - - - + + + GC_ID:1 ncbi_taxonomy - NCBITaxon:8825 - Neognathae + NCBITaxon:33213 + Bilateria - + - - + + GC_ID:1 ncbi_taxonomy - NCBITaxon:88770 - Panarthropoda + NCBITaxon:33317 + Protostomia - + - - - + + + GC_ID:1 - pigeons and others ncbi_taxonomy - NCBITaxon:8929 - Columbiformes + NCBITaxon:33340 + Neoptera - - - - pigeons and others - - - + - - - + + + GC_ID:1 - pigeons ncbi_taxonomy - NCBITaxon:8930 - Columbidae + Holometabola + NCBITaxon:33392 + Endopterygota - - - pigeons - + + + Holometabola + - + - - - + + + GC_ID:1 - Craniata + deuterostomes ncbi_taxonomy - NCBITaxon:89593 - Craniata <chordates> + NCBITaxon:33511 + Deuterostomia - + - Craniata - + deuterostomes + - + - - + + + + + + + + + + + + + + GC_ID:1 + PMID:15019624 + PMID:15371245 ncbi_taxonomy - NCBITaxon:9254 - Prototheria + NCBITaxon:337687 + Muroidea - + - - - + + + GC_ID:1 - egg-laying mammals ncbi_taxonomy - monotremes - NCBITaxon:9255 - Monotremata + NCBITaxon:376913 + Haplorrhini - - - - egg-laying mammals - - - - - - monotremes - - - + - - - + + + + + + + + + + NCBITaxon:109679 GC_ID:1 - echidnas ncbi_taxonomy - NCBITaxon:9259 - Tachyglossidae + NCBITaxon:39107 + Murinae - - - - echidnas - - - + - - - + + + GC_ID:1 - eutherian mammals - placental mammals - placentals + mammal + mammals ncbi_taxonomy - Placentalia - placentals - NCBITaxon:9347 - Eutheria + mammal- + mammals + NCBITaxon:40674 + Mammalia - - - eutherian mammals - - - - + - placental mammals - + mammal + - + - placentals + mammals - + - Placentalia - + mammal- + PRO:DAN + - + - placentals + mammals - + - - - + + + + NCBITaxon:167797 + NCBITaxon:27906 + NCBITaxon:29174 + NCBITaxon:41329 + NCBITaxon:54122 + NCBITaxon:55674 + NCBITaxon:55678 + NCBITaxon:6422 GC_ID:1 - primate + pogonophores + vestimentiferans ncbi_taxonomy - Primata - primates - NCBITaxon:9443 - Primates + Frenulata + Lamellibrachiidae + Obturata + Oligobrachiidae + Perviata + Pogonophora + Polybrachiidae + Sclerolinidae + Vestimentifera + tube worms + NCBITaxon:41324 + Siboglinidae - + - primate - + pogonophores + - + + + vestimentiferans + + + + - Primata + Frenulata - + - primates - + Lamellibrachiidae + - - - - - - - - - GC_ID:1 - ncbi_taxonomy - NCBITaxon:9526 - Catarrhini - - - - - - - - - - GC_ID:1 - great apes - ncbi_taxonomy - Pongidae - NCBITaxon:9604 - Hominidae - - - - great apes - + + + Obturata + - + - Pongidae + Oligobrachiidae + + + + + + Perviata + + + + + + Pogonophora + + + + + + Polybrachiidae + + + + + + Sclerolinidae + + + + + + Vestimentifera + + + + tube worms + + - + - - - + + + GC_ID:1 - humans ncbi_taxonomy - NCBITaxon:9605 - Homo + Neopterygi + NCBITaxon:41665 + Neopterygii - - - humans - + + + Neopterygi + - + - - - + + + GC_ID:1 - human ncbi_taxonomy - NCBITaxon:9606 - Homo sapiens + NCBITaxon:41666 + Batrachia - - - - human - - - + - - - + + + GC_ID:1 - rodent + dinosaur + dinosaurs ncbi_taxonomy - rodents - NCBITaxon:9989 - Rodentia + NCBITaxon:436486 + Dinosauria - + - rodent - + dinosaur + - - - rodents - + + + dinosaurs + - + - + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:436489 + Saurischia + - + - - A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities - PATO:0000072 - quality - PATO:0000001 - quality + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:436491 + Theropoda - - - - A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities - PATOC:GVG - - + - - - A single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts. - PATO:0002015 - composed of - compositionality - content - structure, composition - quality - PATO:0000025 - - - For example calcium composition (which may inhere in bone), haemoglobin composition (which may inhere in blood). - composition + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:436492 + Coelurosauria - - - - A single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts. - PATOC:GVG - - + - - - A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure. - quality - PATO:0000051 - - morphology + + + + NCBITaxon:43732 + GC_ID:1 + ncbi_taxonomy + Asilomorpha + NCBITaxon:43733 + Muscomorpha - - - A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure. - PATOC:GVG + + + Asilomorpha + - + - - - A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc). - PATO:0001647 - relational shape quality - quality - PATO:0000052 - - Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects. - shape + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:43738 + Schizophora - - - - A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc). - PATOC:GVG - - + - - - quality - PATO:0000068 - TODO: define this or obsolete it and move children somewhere else. - qualitative + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:43741 + Acalyptratae - + - - - A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average. - quality - PATO:0000069 - - deviation (from_normal) + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:43746 + Ephydroidea - - - - A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average. - PATOC:GVG - - + - - - A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude. - quality - PATO:0000117 - - - size + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:43845 + Drosophilinae - - - - A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude. - WordNet:WordNet - - + - - - A morphological quality pertaining to the degree to which an object contains an opening, aperture, orifice or vent. - quality - PATO:0000136 - - closure - - - - - A morphological quality pertaining to the degree to which an object contains an opening, aperture, orifice or vent. - PATOC:CJM - PATOC:GVG - + - + - - - A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form. - PATO:0001452 - conformation - relational structural quality - quality - PATO:0000141 - - structure + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:46877 + Drosophilini - - - - A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form. - PATOC:GVG - - - - - conformation - VT:1000738 - - + - - - A morphologic quality inhering in a bearer by virtue of the bearer's relative size, organization and distribution of its surface elements or the representation or invention of the appearance of its surface; visual and tactile surface characteristics. - quality - PATO:0000150 - - texture - - - - - A morphologic quality inhering in a bearer by virtue of the bearer's relative size, organization and distribution of its surface elements or the representation or invention of the appearance of its surface; visual and tactile surface characteristics. - PATOC:GVG - + - + - - - A quality of a single physical entity which is held by a bearer when the latter exhibits a state of growth, differentiation, or development. - quality - PATO:0000261 - - maturity + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:480117 + Cyclorrhapha - - - - A quality of a single physical entity which is held by a bearer when the latter exhibits a state of growth, differentiation, or development. - Merriam-Webster:Merriam-Webster - - + - - - A branchiness quality inhering in a bearer by virtue of the bearer's having branches. - - ramified - ramiform - quality - PATO:0000402 - - - - branched + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:480118 + Eremoneura - - - - A branchiness quality inhering in a bearer by virtue of the bearer's having branches. - WordNet:WordNet - - + - - - A quality inhering in a bearer by virtue of the bearer's having a horizontal surface without a slope, tilt, or curvature. - quality - plate-like - PATO:0000407 - - - - flat - - - - - A quality inhering in a bearer by virtue of the bearer's having a horizontal surface without a slope, tilt, or curvature. - web:http://www.merriam-webster.com/ - + - + - - - A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center. - quality - round - rounded - PATO:0000411 - - - - circular - - - - - A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center. - thefreedictionary.com:thefreedictionary.com - + - + - - - A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average. - - quality - average - PATO:0000461 - - - - normal - - - - - A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average. - PATOC:GVG - + - + - - - - - - - - - - - - - - - - - - - - - A size quality which is relatively high. - - PATO:0001202 - quality - big - enlarged - expanded - great - large - PATO:0000586 - - increased size - - - - - A size quality which is relatively high. - PATOC:GVG - + - + - - - A morphological quality inhering in a bearer by virtue of the bearer's affording blocked passage or view. - - quality - blocked - PATO:0000608 - - closed - - - - - A morphological quality inhering in a bearer by virtue of the bearer's affording blocked passage or view. - answers.com:answers.com - + - + - - - A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section. - ellipse-shaped - ellipsoid - elliptical - quality - oval - ovoid - PATO:0000947 - - - - elliptic + + + + GC_ID:1 + true insects + ncbi_taxonomy + insects + NCBITaxon:50557 + Insecta - - - A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section. - PATOC:GVG + + + true insects + - - - - - - - - An optical quality which obtains by virtue of the ability of the bearer to absorb visible light. - quality - PATO:0000957 - - opacity - - - - An optical quality which obtains by virtue of the ability of the bearer to absorb visible light. - PATOC:GVG + + + insects + - + - - - A optical quality inhering in a bearer by virtue of the bearer's not being clear; not transmitting or reflecting light or radiant energy. - - non-transparent - quality - clouding - cloudy - PATO:0000963 - - - opaque + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:55879 + Rhabditoidea - - - - A optical quality inhering in a bearer by virtue of the bearer's not being clear; not transmitting or reflecting light or radiant energy. - PATOC:GVG - - + - - - A optical quality inhering in a bearer by virtue of the bearer's lacking opacity. - - clear - hyaline - quality - PATO:0000964 - - - transparent + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:55885 + Peloderinae - - - - A optical quality inhering in a bearer by virtue of the bearer's lacking opacity. - PATOC:GVG - - + - - - A physical quality of a fluid inhering in a bearer by virtue of the bearer's disposition to internal resistance to flow. - quality - PATO:0000992 - - - viscosity + + + + GC_ID:1 + sponges + ncbi_taxonomy + Parazoa + sponges + NCBITaxon:6040 + Porifera - - - A physical quality of a fluid inhering in a bearer by virtue of the bearer's disposition to internal resistance to flow. - PATOC:GVG + + + sponges + - - - - - - - - A viscosity quality inhering in a bearer by virtue of the bearer's having viscosity. - quality - PATO:0000998 - - - - viscous - - - - A viscosity quality inhering in a bearer by virtue of the bearer's having viscosity. - PATOC:GVG + + + Parazoa + - - - - - - - - A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities. - PATO:0002079 - Wikipedia:Physical_property - relational physical quality - quality - PATO:0001018 - - physical quality - - - - A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities. - PATOC:GVG + + + sponges + - + - - - A physical quality inhering in a bearer by virtue of the bearer's disposition to recover its size and shape after deformation in any way. - quality - PATO:0001031 - - - - elasticity + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:6072 + Eumetazoa - - - - A physical quality inhering in a bearer by virtue of the bearer's disposition to recover its size and shape after deformation in any way. - merriam-webster:merriam-webster - - + - - - An elasticity quality inhering in a bearer by virtue of the bearer's ability to recover its size and shape after deformation in any way. - - quality - PATO:0001171 - - - - elastic + + + + GC_ID:1 + cnidarians + coelenterates + ncbi_taxonomy + Coelenterata + cnidarians + NCBITaxon:6073 + Cnidaria - - - An elasticity quality inhering in a bearer by virtue of the bearer's ability to recover its size and shape after deformation in any way. - merriam-webster:merriam-webster + + + cnidarians + - - - - - - - - A maturity quality inhering in a bearer by virtue of the bearer's indirect development, undergoing metamorphosis. - quality - PATO:0001185 - - larval - - - - A maturity quality inhering in a bearer by virtue of the bearer's indirect development, undergoing metamorphosis. - Wikipedia:http://en.wikipedia.org/wiki/Larval + + + coelenterates + - - - - - - - - - A quality which inheres in an process. - PATO:0001239 - PATO:0001240 - quality of a process - quality of occurrent - quality of process - relational quality of occurrent - quality - PATO:0001236 - See comments of relational quality of a physical entity. - process quality - - - - A quality which inheres in an process. - PATOC:GVG + + + Coelenterata + - - - - - - - - A quality which inheres in a continuant. - PATO:0001237 - PATO:0001238 - snap:Quality - monadic quality of a continuant - multiply inhering quality of a physical entity - quality of a continuant - quality of a single physical entity - quality of an object - quality of continuant - monadic quality of an object - monadic quality of continuant - quality - PATO:0001241 - Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles. - physical object quality - - - - A quality which inheres in a continuant. - PATOC:GVG + + + cnidarians + - + - - - An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light. - quality - PATO:0001300 - - optical quality + + + + GC_ID:1 + flatworm + flatworms + ncbi_taxonomy + flatworms + NCBITaxon:6157 + Platyhelminthes - - - An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light. - PATOC:GVG + + + flatworm + - - - - - - - - A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism. - quality - PATO:0001374 - - ploidy - - - - A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism. - Wikipedia:http://en.wikipedia.org/wiki/Ploidy + + + flatworms + - - - - - - - - A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes. - quality - PATO:0001375 - - - haploid - - - - A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes. - Wikipedia:http://en.wikipedia.org/wiki/Haploid + + + flatworms + - + - - - A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes. - quality - PATO:0001377 - - - polyploid + + + + GC_ID:1 + nematode + nematodes + roundworm + roundworms + ncbi_taxonomy + Nemata + nematodes + NCBITaxon:6231 + Nematoda - - - A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes. - Wikipedia:http://en.wikipedia.org/wiki/Polyploid + + + nematode + - - - - - - - - A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes. - quality - PATO:0001393 - - - euploid - - - - A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes. - Wikipedia:http://en.wikipedia.org/wiki/Euploid + + + nematodes + - - - - - - - - A monadic quality of continuant that exists at the cellular level of organisation. - quality - PATO:0001396 - cellular quality - - - - A monadic quality of continuant that exists at the cellular level of organisation. - PATOC:GVG + + + roundworm + + + + + + roundworms + + + + + + Nemata + + + + + + nematodes + - + - - - A cellular quality that arises by virtue of whether the bearer's disposition to differentiate into one or more mature cell types. - quality - PATO:0001397 - - - cellular potency + + + + NCBITaxon:33251 + GC_ID:1 + ncbi_taxonomy + NCBITaxon:6236 + Rhabditida - - - - A cellular quality that arises by virtue of whether the bearer's disposition to differentiate into one or more mature cell types. - PATOC:GVG - - + - - - A cellular potency that is the capacity to produce only one differentiated cell type. - quality - PATO:0001400 - - - - Unipotent cells have the quality of self-renewal which distinguishes them from non-stem cells. - unipotent + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:6237 + Caenorhabditis - - - - A cellular potency that is the capacity to produce only one differentiated cell type. - Wikipedia:http://en.wikipedia.org/wiki/Unipotent - - + - - - A cellular potency that is the capacity to form multiple differentiated cell types of a specific lineage and lack self renewing capacity. - quality - PATO:0001401 - - - - Less potent than multipotent, often thought of as precursor or progenitor cell status. - oligopotent + + + + GC_ID:1 + ncbi_taxonomy + Rhabditis elegans + NCBITaxon:6239 + Caenorhabditis elegans - - - A cellular potency that is the capacity to form multiple differentiated cell types of a specific lineage and lack self renewing capacity. - PATOC:MAH + + + Rhabditis elegans + - + - - - A cellular potency that is the capacity to form multiple differentiated cell types. - quality - PATO:0001402 - - - - multipotent + + + + NCBITaxon:54603 + GC_ID:1 + ncbi_taxonomy + NCBITaxon:6243 + Rhabditidae - - - - A cellular potency that is the capacity to form multiple differentiated cell types. - Wikipedia:http://en.wikipedia.org/wiki/Multipotent - - + - - - A cellular quality inhering in a bearer by virtue of bearer's number of nuclei. - quality - PATO:0001404 - - nucleate quality + + + + GC_ID:1 + annelid worms + ncbi_taxonomy + segmented worms + NCBITaxon:6340 + Annelida - - - A cellular quality inhering in a bearer by virtue of bearer's number of nuclei. - PATOC:GVG + + + annelid worms + - - - - - - - - A nucleate quality inhering in a bearer by virtue of the bearer's having no nucleus. - quality - PATO:0001405 - - - - anucleate - - - - A nucleate quality inhering in a bearer by virtue of the bearer's having no nucleus. - Biology-online:Biology-online + + + segmented worms + - + - - - A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei. - quality - PATO:0001406 - - - - binucleate + + + + GC_ID:1 + polychaetes + ncbi_taxonomy + NCBITaxon:6341 + Polychaeta - - - A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei. - Biology-online:Biology-online + + + polychaetes + - + - - - A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus. - quality - PATO:0001407 - - - - mononucleate + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:6362 + Sabellida - - - - A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus. - Biology-online:Biology-online - - + - - - A cellular quality inhering in a bearer by virtue of the bearer's having thin, tail-like projections extending outwards from the cell body. - quality - PATO:0001408 - - - ciliatedness + + + + GC_ID:1 + arthropods + ncbi_taxonomy + arthropods + NCBITaxon:6656 + Arthropoda - - - A cellular quality inhering in a bearer by virtue of the bearer's having thin, tail-like projections extending outwards from the cell body. - Wikipedia:http://en.wikipedia.org/wiki/Ciliated + + + arthropods + - - - - - - - - A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel. - quality - PATO:0001410 - - - - striated - - - - A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel. - Biology-online:Biology-online + + + arthropods + - + - - - A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity characterized by particles arranged such that their shape and volume are relatively stable. - solidity - quality - PATO:0001546 - - quality of a solid + + + + GC_ID:1 + insects + ncbi_taxonomy + Atelocerata + Tracheata + Uniramia + hexapods + NCBITaxon:6960 + Hexapoda - - - A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity characterized by particles arranged such that their shape and volume are relatively stable. - Chemistry:http://chemistry.about.com/od/chemistryglossary/a/soliddefinition.htm + + + insects + + + + + + Atelocerata + + + + + + Tracheata + + + + + + Uniramia + + + + + + hexapods + - + - - - A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity consisting of particles that have neither a defined volume nor defined shape. - gaseous - quality - PATO:0001547 - - quality of a gas + + + + GC_ID:1 + flies + ncbi_taxonomy + flies + NCBITaxon:7147 + Diptera - - - A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity consisting of particles that have neither a defined volume nor defined shape. - Chemistry:http://chemistry.about.com/od/chemistryglossary/a/gasdefinition.htm - PATOC:GVG + + + flies + + + + + + flies + - + - - - A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape. - liquidity - quality - PATO:0001548 - - quality of a liquid + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:7203 + Brachycera - - - - A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape. - url:http://www.chemistry-dictionary.com/definition/liquid.php - - + - - - A physical quality that is the ability to contract or shrink. - quality - PATO:0001579 - - - - contractility + + + + GC_ID:1 + pomace flies + ncbi_taxonomy + NCBITaxon:7214 + Drosophilidae - - - A physical quality that is the ability to contract or shrink. - WordNet:WordNet + + + pomace flies + - + - - - - - - - - - - - - - - - - - - - - - A contractility which is relatively high. - - high contractility - quality - PATO:0001580 - - - increased contractility + + + + NCBITaxon:7326 + GC_ID:1 + Drosophila + fruit flies + fruit fly + ncbi_taxonomy + NCBITaxon:7215 + Drosophila <flies,genus> - - - A contractility which is relatively high. - PATO:GVG + + + Drosophila + + + + + + fruit flies + + + + + + fruit fly + - + - - - A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending. - quality - PATO:0001591 - - curvature + + + + NCBITaxon:2267365 + GC_ID:1 + fruit fly + ncbi_taxonomy + Sophophora melanogaster + NCBITaxon:7227 + Drosophila melanogaster - - - A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending. - WordNet:WordNet + + + fruit fly + + + + + + Sophophora melanogaster + - + - - - A contractility quality inhering in a bearer by virtue of the bearer's ability of contracting or being contracted. - - quality - PATO:0001690 - - - This refers to the disposition of the bearer. - contractile + + + + GC_ID:1 + Pterygota + winged insects + ncbi_taxonomy + NCBITaxon:7496 + Pterygota <insects> - - - A contractility quality inhering in a bearer by virtue of the bearer's ability of contracting or being contracted. - PATOC:GVG + + + Pterygota + + + + + + winged insects + - + - - - - - - - - - - - - - - - - - - - - - A viscosity which relatively high. - - high viscosity - quality - PATO:0001693 - - - increased viscosity + + + + GC_ID:1 + chordates + ncbi_taxonomy + chordates + NCBITaxon:7711 + Chordata - - - A viscosity which relatively high. - PATOC:GVG + + + chordates + + + + + + chordates + - + - - - A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of liquids. - liquid - quality - PATO:0001735 - liquid configuration + + + + GC_ID:1 + tunicates + ncbi_taxonomy + Urochordata + tunicates + NCBITaxon:7712 + Tunicata - - - A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of liquids. - PATOC:GVG + + + tunicates + + + + + + Urochordata + + + + + + tunicates + - + - - - A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of solids. - solid - quality - PATO:0001736 - - solid configuration + + + + GC_ID:1 + Vertebrata + vertebrates + ncbi_taxonomy + vertebrates + NCBITaxon:7742 + Vertebrata <vertebrates> - - - A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of solids. - PATOC:GVG + + + Vertebrata + + + + + + vertebrates + + + + + + vertebrates + - + - - - A shape quality in which a portion of the outermost boundary of an entity folds in space such that a portion that was originally convex is now concave. - quality - PATO:0001748 - - - - invaginated + + + + GC_ID:1 + ncbi_taxonomy + Myxinoidea + hagfishes + NCBITaxon:7761 + Myxiniformes - - - A shape quality in which a portion of the outermost boundary of an entity folds in space such that a portion that was originally convex is now concave. - PATOC:GVG + + + Myxinoidea + + + + + + hagfishes + - + - - - A shape quality in a bearer by virtue of the bearer's curving inward. - - quality - PATO:0001857 - - - concave + + + + GC_ID:1 + hagfishes + ncbi_taxonomy + NCBITaxon:7762 + Myxinidae - - - A shape quality in a bearer by virtue of the bearer's curving inward. - WordNet:WordNet + + + hagfishes + - + - - - - - - - - - A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a consistently-sized round cross section. - PATO:0001203 - rod-like - rod-shaped - tubulate - quality - PATO:0001873 - - - cylindrical + + + + GC_ID:1 + Gnathostomata + jawed vertebrates + ncbi_taxonomy + NCBITaxon:7776 + Gnathostomata <vertebrates> - - - A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a consistently-sized round cross section. - PATOC:MAH + + + Gnathostomata + + + + + + jawed vertebrates + - + - - - A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus. - quality - PATO:0001908 - - - multinucleate + + + + GC_ID:1 + cartilaginous fishes + fish + fishes + ncbi_taxonomy + cartilaginous fishes + NCBITaxon:7777 + Chondrichthyes - - - A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus. - PATOC:GVG + + + cartilaginous fishes + + + + + + fish + + + + + + fishes + + + + + + cartilaginous fishes + - + - - - A structural quality inhering in a bearer by virtue of the bearer's having a three dimensional cavity with a narrow or no opening, and often containing an anatomical substance. - sacular - quality - PATO:0001987 - - saccular + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:7863 + Holocephali - - - - A structural quality inhering in a bearer by virtue of the bearer's having a three dimensional cavity with a narrow or no opening, and often containing an anatomical substance. - PATOC:MAH - - + - - - An organismal quality inhering in a bearer by virtue of the bearer's consisting cells. - quality - PATO:0001992 - - - cellularity + + + + GC_ID:1 + chimaeras + ncbi_taxonomy + chimaeras + NCBITaxon:7864 + Chimaeriformes - - - An organismal quality inhering in a bearer by virtue of the bearer's consisting cells. - PATOC:GVG + + + chimaeras + + + + + + chimaeras + - + - - - A cellularity quality inhering in a bearer by virtue of the bearer's consisting of more than one cell. - quality - PATO:0001993 - - multicellular + + + + GC_ID:1 + dipnoans + fish + fishes + lungfishes + ncbi_taxonomy + Choanichthyes + Dipneusti + Dipnoi + Osteichthyes + lungfishes + NCBITaxon:7878 + Dipnomorpha - - - A cellularity quality inhering in a bearer by virtue of the bearer's consisting of more than one cell. - PATOC:GVG + + + dipnoans + + + + + + fish + + + + + + fishes + + + + + + lungfishes + + + + + + Choanichthyes + + + + + + Dipneusti + + + + + + Dipnoi + + + + + + Osteichthyes + + + + + + lungfishes + - + - - - A quality that inheres in an entire organism or part of an organism. - quality - PATO:0001995 - organismal quality + + + + GC_ID:1 + fish + fishes + ray-finned fishes + ncbi_taxonomy + Actinopterygi + Osteichthyes + bony fishes + NCBITaxon:7898 + Actinopterygii - - - A quality that inheres in an entire organism or part of an organism. - PATOC:CJM + + + fish + + + + + + fishes + + + + + + ray-finned fishes + + + + + + Actinopterygi + + + + + + Osteichthyes + + + + + + bony fishes + - + - - - Surface shape that refers to the inward or outward curvature of the surface. - quality - PATO:0002005 - - concavity + + + + GC_ID:1 + sturgeons and paddlefish + ncbi_taxonomy + NCBITaxon:7899 + Acipenseriformes - - - Surface shape that refers to the inward or outward curvature of the surface. - PATOC:MAH + + + sturgeons and paddlefish + - + - - - A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity. - quality - 2-D projection - cross-sectional - PATO:0002006 - - 2-D shape + + + + GC_ID:1 + sturgeons + ncbi_taxonomy + NCBITaxon:7900 + Acipenseridae - - - A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity. - PATOC:CJM + + + sturgeons + - + - - - - - - - - - A complete three dimensional shape in which for every line connecting pair of points on the object is within the object. Or: a shape lacking cavities. Contrast: concave. - - Image:http://upload.wikimedia.org/wikipedia/commons/0/06/Convex_polygon_illustration1.png - quality - PATO:0002007 - - Use this term or an is_a child of this term when the entire shape of the object is known. - convex 3-D shape + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:7901 + Acipenser - - - - A complete three dimensional shape in which for every line connecting pair of points on the object is within the object. Or: a shape lacking cavities. Contrast: concave. - PATOC:CJM - - + - - - A shape quality inhering in a bearer by virtue of the degree to which there are subdivisions or offshoots in a bearer entity. - quality - PATO:0002009 - - - branchiness + + + + GC_ID:1 + carps and others + ncbi_taxonomy + NCBITaxon:7952 + Cypriniformes - - - A shape quality inhering in a bearer by virtue of the degree to which there are subdivisions or offshoots in a bearer entity. - PATOC:MAH + + + carps and others + - + - - - A structural quality that inheres in a bearer by virtue of the bearer's containing hollow areas. - quality - PATO:0002014 - - structure, cavities + + + + NCBITaxon:46777 + NCBITaxon:487617 + GC_ID:1 + ncbi_taxonomy + Brachydanio + Celestichthys + NCBITaxon:7954 + Danio - - - A structural quality that inheres in a bearer by virtue of the bearer's containing hollow areas. - PATOC:GVG + + + Brachydanio + + + + + + Celestichthys + - + - - - A concave quality inhering in a bearer by virtue of the bearer's curving inward on both sides or surfaces. - - quality - PATO:0002039 - - biconcave + + + + NCBITaxon:27702 + NCBITaxon:37966 + GC_ID:1 + leopard danio + zebra danio + zebra fish + zebrafish + ncbi_taxonomy + Brachydanio rerio + Brachydanio rerio frankei + Cyprinus rerio + Danio frankei + Danio rerio frankei + NCBITaxon:7955 + Danio rerio - - - A concave quality inhering in a bearer by virtue of the bearer's curving inward on both sides or surfaces. - PATOC:GVG + + + leopard danio + + + + + + zebra danio + + + + + + zebra fish + + + + + + zebrafish + + + + + + Brachydanio rerio + + + + + + Brachydanio rerio frankei + + + + + + Cyprinus rerio + + + + + + Danio frankei + + + + + + Danio rerio frankei + - + - - - A branched quality inhering in a bearer by virtue of the bearer's having smaller branches arising from larger branches. Resembling a tree in branching structure. - - 2009-02-15T08:11:41Z - dendriform - dendroid - dendroidal - quality - PATO:0002045 - - dendritic + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:8287 + Sarcopterygii - - - - A branched quality inhering in a bearer by virtue of the bearer's having smaller branches arising from larger branches. Resembling a tree in branching structure. - PATOC:cvs - - + - - - - 2009-06-05T09:16:46Z - quality - PATO:0002062 - - physical quality of a process + + + + GC_ID:1 + amphibians + ncbi_taxonomy + amphibians + NCBITaxon:8292 + Amphibia + + + + amphibians + + + + + + amphibians + + - + - - - A quality inhering in a bearer by virtue of the bearer's having an empty space or cavity within. - - 2009-09-18T02:19:20Z - quality - PATO:0002078 - - hollow + + + + GC_ID:1 + anurans + frogs + frogs and toads + ncbi_taxonomy + Salientia + frogs & toads + NCBITaxon:8342 + Anura - - - A quality inhering in a bearer by virtue of the bearer's having an empty space or cavity within. - url:http://www.merriam-webster.com/dictionary/hollow + + + anurans + + + + + + frogs + + + + + + frogs and toads + + + + + + Salientia + + + + + + frogs & toads + - + - - - An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for basic dyes under specific pH conditions. - - 2009-10-05T12:05:23Z - quality - PATO:0002094 - - - - basophilic + + + + GC_ID:1 + PMID:2385174 + pipid frogs + tongueless frogs + ncbi_taxonomy + NCBITaxon:8352 + Pipidae - - - An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for basic dyes under specific pH conditions. - PATOC:GVG + + + pipid frogs + - - - - - - - - A quality inhering in a bearer by virtue of the bearer's processing the form of a thin plate sheet or layer. - - 2009-10-06T04:37:14Z - quality - PATO:0002124 - - - laminar - - - - A quality inhering in a bearer by virtue of the bearer's processing the form of a thin plate sheet or layer. - PATOC:GVG + + + tongueless frogs + - + - - - A quality inhering in a bearer by virtue of its constitution. - - 2010-03-15T04:35:27Z - quality - PATO:0002198 - - quality of a substance + + + + GC_ID:1 + PMID:2385174 + Xenopus + ncbi_taxonomy + NCBITaxon:8353 + Xenopus <genus> - - - A quality inhering in a bearer by virtue of its constitution. - PATOC:GVG + + + Xenopus + - + - - - A cylindrical shape quality inhering in a bearer by virtue of the bearer's being imperfectly cylindrical or approximately cylindrical. - - 2010-07-13T04:22:30Z - quality - PATO:0002226 - - subcylindrical + + + + GC_ID:1 + African clawed frog + clawed frog + common platanna + platanna + ncbi_taxonomy + Bufo laevis + NCBITaxon:8355 + Xenopus laevis - - - A cylindrical shape quality inhering in a bearer by virtue of the bearer's being imperfectly cylindrical or approximately cylindrical. - url:http://www.thefreedictionary.com/Subcylindrical + + + African clawed frog + - - - - - - - - A quality inhering in a bearer by virtue of the bearer's surface becoming more extended in a plane. - - 2010-08-16T03:59:34Z - quality - compressed - PATO:0002254 - - Becoming flat but not necessarily completely flat. - flattened - - - - A quality inhering in a bearer by virtue of the bearer's surface becoming more extended in a plane. - PATOC:CVS + + + clawed frog + + + + + + common platanna + + + + + + platanna + + + + + + Bufo laevis + - + - - - Texture quality inhering in a bearer by virtue of the bearer's being marked with one or more channels. - - 2010-09-01T10:27:48Z - quality - channeled - creased - PATO:0002255 - - grooved + + + + GC_ID:1 + PMID:2385174 + ncbi_taxonomy + Siluraninae + NCBITaxon:8360 + Xenopodinae - - - Texture quality inhering in a bearer by virtue of the bearer's being marked with one or more channels. - PATOC:JE + + + Siluraninae + - + - - - A shape that inheres in a 3 dimensional entity. - - 2010-10-05T12:31:16Z - quality - PATO:0002266 - 3-D shape + + + + GC_ID:1 + sauropsids + ncbi_taxonomy + NCBITaxon:8457 + Sauropsida - - - A shape that inheres in a 3 dimensional entity. - PATOC:OREGON + + + sauropsids + - + - - - - - - - - - - - - - - - - - - - - - An elasticity which is relatively high. - - - 2011-03-30T11:50:21Z - quality - PATO:0002287 - - increased elasticity + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:8492 + Archosauria - - - - An elasticity which is relatively high. - PATOC:GVG - - + - - - - A cylindrical shape that is hollow. - - 2011-06-08T06:33:50Z - tube like - tube-shaped - tubulate - quality - PATO:0002299 - tubular + + + + GC_ID:1 + PMID:22982760 + lepidosaurs + ncbi_taxonomy + Reptilia + lizards & snakes + reptiles + NCBITaxon:8504 + Lepidosauria - - - A cylindrical shape that is hollow. - PATOC:GVG + + + lepidosaurs + + + + + + Reptilia + + + + + + lizards & snakes + + + + + + reptiles + - + - - - - - - - - - - - - - - - - - - - - A quality that has a value that is increased compared to normal or average. - - - 2011-06-16T06:39:43Z - quality - PATO:0002300 - increased quality + + + + GC_ID:1 + beaked reptiles + rhynchocephalians + ncbi_taxonomy + Rhynchocephalia + Rhynchosauria + NCBITaxon:8505 + Sphenodontia - - - A quality that has a value that is increased compared to normal or average. - PATOC:GVG + + + beaked reptiles + + + + + + rhynchocephalians + + + + + + Rhynchocephalia + + + + + + Rhynchosauria + - + - - - - - - - - - - - - - - - - - - - - - A quality of a process that has a value that is increased compared to normal or average. - - - 2011-06-16T06:53:08Z - quality - PATO:0002304 - increased process quality + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:8506 + Sphenodontidae - - - - A quality of a process that has a value that is increased compared to normal or average. - PATOC:GVG - - + - - - - - - - - - - - - - - - - - - - - - A quality of an object that has a value that is increased compared to normal or average. - - - 2011-06-16T06:54:01Z - quality - PATO:0002305 - increased object quality + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:8507 + Sphenodon - - - - A quality of an object that has a value that is increased compared to normal or average. - PATOC:GVG - - + - - - A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a by virtue of the bearer's exhibiting a consistently sized and approximately round cross-section along its length, which is many times larger than its diameter. - - 2011-09-09T04:50:10Z - quality - PATO:0002309 - - Note that a fiber shaped object may take any circuitous or straight path through space (think of a length of string or rope). - fiber shaped + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:85512 + Dicondylia - - - - A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a by virtue of the bearer's exhibiting a consistently sized and approximately round cross-section along its length, which is many times larger than its diameter. - PATOC:DC - - + - - - A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt - - 2011-10-12T12:45:16Z - Lamé curve - quality - PATO:0002318 - superelliptic + + + + GC_ID:1 + birds + ncbi_taxonomy + avian + birds + NCBITaxon:8782 + Aves - - - A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt - wiktionary:superellipse + + + birds + + + + + + avian + + + + + + birds + - + - - - An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for acidic dyes under specific pH conditions. - - 2012-12-17T03:01:19Z - eosinophilic - quality - PATO:0002418 - - - Eosin stains acidophilic structures, hence eosinophilic is the same as acidophilic. - acidophilic + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:8783 + Palaeognathae - - - - An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for acidic dyes under specific pH conditions. - PATOC:GVG - - + - - - Pertaining to the individual parts making up an aggregate fruit like a many-lobed "berry," such as a raspberry. - - 2012-12-17T03:11:10Z - quality - PATO:0002422 - - - Acinus is Latin for berry. - acinar + + + + GC_ID:1 + ostriches + ncbi_taxonomy + NCBITaxon:8798 + Struthioniformes - - - Pertaining to the individual parts making up an aggregate fruit like a many-lobed "berry," such as a raspberry. - wikipedia:https://en.wikipedia.org/wiki/Acinus + + + ostriches + - + - - - A composition quality inhering in an bearer by virtue of the bearer's consisting of collagen. - - 2013-09-15T11:34:15Z - quality - PATO:0002462 - - collagenous + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:8799 + Struthionidae - - - - A composition quality inhering in an bearer by virtue of the bearer's consisting of collagen. - PATOC:WD - - + - - - A structure quality inhering in a bearer by virtue of the bearer's being capable of swelling or stretching. - - 2013-09-15T11:48:26Z - quality - PATO:0002468 - - distensible + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:8800 + Struthio - - - - A structure quality inhering in a bearer by virtue of the bearer's being capable of swelling or stretching. - PATOC:WD - - + - - - A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel, that are oriented transversely relative to the long axis of the bearer. - - 2013-09-15T12:29:15Z - quality - PATO:0002478 - - - - transversely striated + + + + GC_ID:1 + African ostrich + ostrich + ncbi_taxonomy + Struthio camelus domesticus + NCBITaxon:8801 + Struthio camelus - - - A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel, that are oriented transversely relative to the long axis of the bearer. - PATOC:DS + + + African ostrich + + + + + + ostrich + + + + + + Struthio camelus domesticus + - + - - - A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus. - - 2013-10-21T05:44:34Z - quality - PATO:0002505 - - - nucleated + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:8825 + Neognathae - - - - A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus. - PATOC:GVG - - + - - - A structural quality inhering in the bearer by virtue of the bearer consisting of multiple structures lacking any physical connection to each other. - - 2014-12-12T08:43:17Z - quality - PATO:0010001 - disconnected + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:88770 + Panarthropoda - - - - A structural quality inhering in the bearer by virtue of the bearer consisting of multiple structures lacking any physical connection to each other. - GOC:dos - - + - - - A quality inhering in a structure by virtue of it consisting of many of repeated, similar or identical subunits, arranged in some orderly array. - quality - PATO:0015006 - - A complete coverage of this domain would subclasses homopolymeric, copolymeric, crystalline. - polymeric + + + + GC_ID:1 + pigeons and others + ncbi_taxonomy + NCBITaxon:8929 + Columbiformes - - - A quality inhering in a structure by virtue of it consisting of many of repeated, similar or identical subunits, arranged in some orderly array. - GOC:DOS - https://github.com/pato-ontology/pato/issues/78 + + + pigeons and others + - + - - - A quality inhering in a bearer by virtue of the extent to which the bearer is capable of being stretched or swollen. - quality - PATO:0015008 - - distensibility + + + + GC_ID:1 + pigeons + ncbi_taxonomy + NCBITaxon:8930 + Columbidae - - - A quality inhering in a bearer by virtue of the extent to which the bearer is capable of being stretched or swollen. - GOC:CJM + + + pigeons + - + - - - A quality of continuant that exist at the anatomical level of organisation and anything under it. This includes, but is not limited to, cells , tissues, and components. - http://orcid.org/0000-0001-7258-9596 - quality - PATO:0070044 - anatomical structure quality + + + + GC_ID:1 + Craniata + ncbi_taxonomy + NCBITaxon:89593 + Craniata <chordates> + + + + Craniata + + - + - - - A quality inhering in an anotomical structure by virtue of its capacity to be stained by specific histological dyes. - http://orcid.org/0000-0001-7258-9596 - quality - PATO:0070045 - anatomical histological quality + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:9254 + Prototheria - + - - - An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for both basic and acid stains under specific pH conditions. - http://orcid.org/0000-0001-7258-9596 - quality - PATO:0070047 - polychromatophilic + + + + GC_ID:1 + egg-laying mammals + ncbi_taxonomy + monotremes + NCBITaxon:9255 + Monotremata - - - An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for both basic and acid stains under specific pH conditions. - GOC:add + + + egg-laying mammals + + + + + + monotremes + - + - - - A quality of a substance on which or through which electromagnetic radiation impinges or traverses with respect to radiation. This substance quality changes the quality of the incident radiation with respect to any of: intensity, direction, scatter and wavelength. - quality - PATO:0070060 - - quality of interaction of a substance with electromagnetic radiation + + + + GC_ID:1 + echidnas + ncbi_taxonomy + NCBITaxon:9259 + Tachyglossidae - - - A quality of a substance on which or through which electromagnetic radiation impinges or traverses with respect to radiation. This substance quality changes the quality of the incident radiation with respect to any of: intensity, direction, scatter and wavelength. - https://orcid.org/0000-0002-5111-7263 + + + echidnas + - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof. - natural protein - native protein - protein - PR:000000001 - The definition above excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to CHEBI:36080. Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB]. - protein + + + + GC_ID:1 + eutherian mammals + placental mammals + placentals + ncbi_taxonomy + Placentalia + placentals + NCBITaxon:9347 + Eutheria - - - An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof. - PRO:DAN - PRO:WCB + + + eutherian mammals + - + - natural protein - PRO:DAN + placental mammals + - - - native protein - IEDB:BP + + + placentals + + + + + + Placentalia + + + + + + placentals + - + - - - A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction. - IUPHARobj:2764 - PIRSF:PIRSF016630 - B-lymphocyte surface antigen B4 - CD19 - T-cell surface antigen Leu-12 - differentiation antigen CD19 - protein - PR:000001002 - Category=gene. Requested by=CL. - CD19 molecule + + + + GC_ID:1 + primate + ncbi_taxonomy + Primata + primates + NCBITaxon:9443 + Primates - - - A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction. - PMID:15778510 + + + primate + - - - CD19 - PRO:DNx - + + + Primata + + + + + + primates + - + - - - A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved. - PIRSF:PIRSF028749 - CD34 - hematopoietic progenitor cell antigen CD34 - protein - PR:000001003 - Category=gene. Requested by=CL. - CD34 molecule + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:9526 + Catarrhini - - - - A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved. - PMID:16720896 - PMID:8983065 - - - - - CD34 - PRO:DNx - - - + - - - A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence. - PIRSF:PIRSF001977 - CD4 - T-cell differentiation antigen L3T4 - T-cell surface antigen T4/Leu-3 - T-cell surface glycoprotein CD4 - protein - PR:000001004 - Category=gene. Requested by=CL. - CD4 molecule + + + + GC_ID:1 + great apes + ncbi_taxonomy + Pongidae + NCBITaxon:9604 + Hominidae - - - A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence. - PMID:15326605 + + + great apes + - - - CD4 - PRO:DNx - + + + Pongidae + - + - - - An integrin alpha that contains an A domain. A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. Unlike other integrin alpha proteins, they do not undergo proteolytic cleavage. - PIRSF:PIRSF002497 - integrin alpha with I domain - protein - PR:000001005 - Category=family. - integrin alpha with A domain + + + + GC_ID:1 + humans + ncbi_taxonomy + NCBITaxon:9605 + Homo - - - An integrin alpha that contains an A domain. A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. Unlike other integrin alpha proteins, they do not undergo proteolytic cleavage. - PIRSF:PIRSF002497 + + + humans + - + - - - An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1. - IUPHARobj:2452 - CD11 antigen-like family member B - CD11b - CR-3 alpha chain - ITGAM - cell surface glycoprotein MAC-1 subunit alpha - leukocyte adhesion receptor MO1 - neutrophil adherence receptor - protein - CD11B - CR3A - PR:000001012 - Category=gene. Requested by=CL. - integrin alpha-M - + + + + GC_ID:1 + human + ncbi_taxonomy + h + human + NCBITaxon:9606 + Homo sapiens - - - An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1. - UniProtKB:P11215 - - - + - ITGAM - PRO:DNx - + human + - + - CD11B - + h + PRO:DAN + - + - CR3A - - - - - - - - - - A protein that has a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response. - PIRSF:PIRSF001993 - CD3 subunit with Ig-like domain - protein - PR:000001018 - Category=family. - CD3 subunit with immunoglobulin domain - - - - - A protein that has a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response. - PMID:16473826 - PMID:1724736 + human + PRO:DAN + - + - - - A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3E gene or a 1:1 ortholog thereof. - IUPHARobj:2742 - CD3E - CD3e - T-cell surface antigen T3/Leu-4 epsilon chain - protein - T3E - PR:000001020 - Category=gene. Requested by=CL. - CD3 epsilon + + + + GC_ID:1 + rodent + ncbi_taxonomy + rodents + NCBITaxon:9989 + Rodentia - - - A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3E gene or a 1:1 ortholog thereof. - PRO:CNA + + + rodent + - + - CD3E - PRO:DNx - + rodent + - + - T3E - + rodents + - + - - - A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (Pfam:PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain. - PIRSF:PIRSF002507 - protein - PR:000001022 - Category=family. - neural cell adhesion molecule + + + planned process - - - - A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (Pfam:PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain. - PRO:CNA - - + - - - A neural cell adhesion molecule that is involved in neuronal development, synaptic plasticity, and regeneration. - PIRSF:PIRSF501037 - protein - PR:000001023 - Category=family. - neural cell adhesion molecule NCAM + + + + + + + + + + + + + obi + OBI:0100026 + Category=external. + organism + organism - - - - A neural cell adhesion molecule that is involved in neuronal development, synaptic plasticity, and regeneration. - PMID:17975827 - - + - - - A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof. - IUPHARobj:2769 - CD56 - N-CAM-1 - NCAM-1 - NCAM1 - protein - NCAM - PR:000001024 - Category=gene. Requested by=CL. - neural cell adhesion molecule 1 - + + + A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities + quality (PATO) + PATO:0000072 + quality + PATO:0000001 + quality - + - A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof. - PRO:CNA - - - - - NCAM1 - PRO:DNx - - - - - - NCAM - + A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities + PATOC:GVG - + - - - A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof. - IUPHARobj:2600 - PIRSF:PIRSF001984 - CD2 - LFA-2 - LFA-3 receptor - T-cell surface antigen CD2 - T-cell surface antigen T11/Leu-5 - T-cell surface glycoprotein CD2 - erythrocyte receptor - ly-37 - lymphocyte antigen 37 - rosette receptor - protein - SRBC - PR:000001083 - Category=gene. Requested by=CL. - CD2 molecule + + + composition - - - - A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof. - PRO:CNA - - - - - CD2 - PRO:DNx - - - - - - SRBC - - - + - - - A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain. - CD8A - CD8a - T-cell surface glycoprotein Lyt-2 - T-lymphocyte differentiation antigen T8/Leu-2 - protein - Lyt-2 - Lyt2 - MAL - PR:000001084 - Category=gene. Requested by=CL. - T-cell surface glycoprotein CD8 alpha chain - + + + A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure. + quality + PATO:0000051 + + morphology - + - A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain. - PMID:11114424 - PRO:CNA - Wikipedia:CD8 - - - - - CD8A - PRO:DNx - - - - - - Lyt-2 - - - - - - Lyt2 - - - - - - MAL - + A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure. + PATOC:GVG - + - - - A protein that is a translation product of the human MS4A1 gene or a 1:1 ortholog thereof. - IUPHARobj:2628 - PIRSF:PIRSF001995 - B-cell differentiation antigen Ly-44 - B-cell surface antigen CD20 - B-lymphocyte antigen CD20 - B-lymphocyte surface antigen B1 - Bp35 - MS4A1 - leukocyte surface antigen Leu-16 - lymphocyte antigen 44 - protein - CD20 - Ly-44 - Ms4a2 - PR:000001289 - Category=gene. Requested by=CL. - membrane-spanning 4-domains subfamily A member 1 + + + A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc). + PATO:0001647 + relational shape quality + quality + PATO:0000052 + + Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects. + shape - + - A protein that is a translation product of the human MS4A1 gene or a 1:1 ortholog thereof. - PRO:WCB - - - - - MS4A1 - PRO:DNx - - - - - - CD20 - - - - - - Ly-44 - - - - - - Ms4a2 - + A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc). + PATOC:GVG - + - - - A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues. - PIRSF:PIRSF002504 - protein - PR:000001327 - Category=family. - cadherin + + + closure - - - - A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues. - PRO:WCB - - + - - - A cadherin that is a translation product of the human CDH5 gene or a 1:1 ortholog thereof. - 7B4 antigen - CD144 - CDH5 - VE-cadherin - vascular endothelial cadherin - protein - PR:000001444 - Category=gene. Requested by=CL. - cadherin-5 - + + + structure - - - - A cadherin that is a translation product of the human CDH5 gene or a 1:1 ortholog thereof. - PRO:WCB - - - - - CDH5 - PRO:DNx - - - + - - - A protein that is a translation product of the human CD5 gene or a 1:1 ortholog thereof. - CD5 - Lyt-1 - ly-1 - lymphocyte antigen 1 - lymphocyte antigen T1/Leu-1 - protein - LEU1 - PR:000001839 - Category=gene. Requested by=CL. - T-cell surface glycoprotein CD5 - + + + texture - - - - A protein that is a translation product of the human CD5 gene or a 1:1 ortholog thereof. - PRO:WCB - - - - - CD5 - PRO:DNx - - - - - - LEU1 - - - + - - - A protein that is a translation product of the human IL7R gene or a 1:1 ortholog thereof. - IUPHARobj:1698 - PIRSF:PIRSF001960 - CD127 - CDw127 - IL-7 receptor subunit alpha - IL-7R subunit alpha - IL-7R-alpha - IL-7RA - IL7R - protein - PR:000001869 - Category=gene. Requested by=CL. - interleukin-7 receptor subunit alpha - + + + maturity - - - - A protein that is a translation product of the human IL7R gene or a 1:1 ortholog thereof. - PRO:WCB - - - - - IL7R - PRO:DNx - - - + - - - A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof. - PIRSF:PIRSF002017 - CD14 - monocyte differentiation antigen CD14 - myeloid cell-specific leucine-rich glycoprotein - protein - PR:000001889 - Category=gene. Requested by=CL. - CD14 molecule + + + branched - - - - A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof. - PRO:WCB - - - - - CD14 - PRO:DNx - - - + - - - A protein that is a translation product of the human TFRC gene or a 1:1 ortholog thereof. - p90 - CD71 - T9 - TFRC - TfR - TfR1 - protein - TR - Trfr - PR:000001945 - Category=gene. Requested by=CL. - transferrin receptor protein 1 - + + + flat + + + + + + + + + closed + + + + + + + + + opacity + + + + + + + + + opaque - - - - A protein that is a translation product of the human TFRC gene or a 1:1 ortholog thereof. - PRO:WCB - - - - - p90 - PRO:DNx - - - - - TFRC - PRO:DNx - - - - - - Trfr - - - + - - - A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain. - PIRSF:PIRSF038502 - protein - PR:000001971 - Category=family. - vascular endothelial growth factor receptor + + + transparent - - - - A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain. - PRO:WCB - - + - - - A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof. - IUPHARobj:1813 - CD309 - FLK-1 - KDR - VEGFR-2 - fetal liver kinase 1 - kinase NYK - kinase insert domain receptor - protein-tyrosine kinase receptor flk-1 - protein - FLK1 - VEGFR2 - PR:000002112 - Category=gene. Requested by=CL. - vascular endothelial growth factor receptor 2 - + + + viscosity - - - - A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof. - PRO:WCB - - - - - KDR - PRO:DNx - - - - - - FLK1 - - - - - - VEGFR2 - - - + - - - A protein that is the translation product of any of the LY6 genes (LY6A-LY6I). - PIRSF:PIRSF002021 - protein - PR:000002976 - Category=family. - Ly-6-like protein + + + viscous - - - - A protein that is the translation product of any of the LY6 genes (LY6A-LY6I). - PRO:CNA - - + - - - An Ly-6-like protein that is a translation product of the mouse Ly6g gene or a 1:1 ortholog thereof. - Ly-6G - Ly-6G.1 - Ly6g - protein - PR:000002978 - Category=gene. Requested by=CL. - lymphocyte antigen 6G + + + A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities. + PATO:0002079 + Wikipedia:Physical_property + relational physical quality + quality + PATO:0001018 + + physical quality - + - An Ly-6-like protein that is a translation product of the mouse Ly6g gene or a 1:1 ortholog thereof. - PRO:CNA - - - - - Ly6g - PRO:DNx - + A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities. + PATOC:GVG - + - - - - - - - - - A protein that is a translation product of the Ly76 gene in mouse. - mLy76 - ter-119 - ter119 - protein - PR:000002981 - Category=organism-gene. Requested by=CL. - lymphocyte antigen 76 (mouse) + + + elasticity - - - - A protein that is a translation product of the Ly76 gene in mouse. - PMID:10848813 - PRO:DAN - - - - - mLy76 - PRO:DNx - - - + - - - A protein that is a translation product of the human FGF8 gene or a 1:1 ortholog thereof. - FGF-8 - FGF8 - androgen-induced growth factor - protein - AIGF - HBGF-8 - heparin-binding growth factor 8 - PR:000007499 - Category=gene. - fibroblast growth factor 8 - + + + elastic - - - - A protein that is a translation product of the human FGF8 gene or a 1:1 ortholog thereof. - PRO:DNx - - - - - FGF8 - PRO:DNx - - - - - - AIGF - - - + - - - An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof. - insulin - INS - protein - PR:000009054 - Category=gene. - insulin gene translation product - + + + larval - - - - An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof. - PRO:DNx - - - - - insulin - PRO:DAN - - - - - INS - PRO:DNx - - - + - - - A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof. - HHG-1 - SHH - Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains - ShhNC - protein - Hhg1 - PR:000014841 - Category=gene. - sonic hedgehog protein - + + + process quality - - - - A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof. - PRO:DNx - - - - - SHH - PRO:DNx - - - - - - Hhg1 - - - + - - - A protein that is a translation product of the human TAL1 gene or a 1:1 ortholog thereof. - T-cell leukemia/lymphoma protein 5 - TAL-1 - TAL1 - bHLHa17 - class A basic helix-loop-helix protein 17 - stem cell protein - protein - BHLHA17 - SCL - TCL5 - PR:000016043 - Category=gene. Requested by=CL. - T-cell acute lymphocytic leukemia protein 1 - + + + + A quality which inheres in a continuant. + PATO:0001237 + PATO:0001238 + snap:Quality + monadic quality of a continuant + multiply inhering quality of a physical entity + quality of a continuant + quality of a single physical entity + quality of an object + quality of continuant + monadic quality of an object + monadic quality of continuant + quality + PATO:0001241 + Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles. + physical object quality - + - A protein that is a translation product of the human TAL1 gene or a 1:1 ortholog thereof. - PRO:DNx - - - - - TAL1 - PRO:DNx - - - - - - BHLHA17 - - - - - - SCL - - - - - - TCL5 - + A quality which inheres in a continuant. + PATOC:GVG - + - - - - - - 2 - - - - An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds. - peptide - polypeptide - protein - PR:000018263 - Category=polymer. - amino acid chain + + + electromagnetic (EM) radiation quality - - - - An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds. - PRO:DAN - PRO:JSG - - - - - peptide - PRO:DAN - - - - - polypeptide - PRO:DAN - - + - - - A protein that is composed of a long N-terminal extracellular domain, a transmembrane domain and a short cytoplasmic C-terminal domain. The N-terminal domain contains beta-propeller repeats (interrupted by an A domain in a subset of integrins alpha), while the C-terminal domain contains a GFFxR motif. - protein - PR:000025796 - Category=family. Integrins are heterodimeric complexes of an alpha and a beta subunit. They are a structurally elaborate family of adhesion molecules that transmit signals bidirectionally across the plasma membrane by undergoing large-scale structural rearrangements. By regulating cell-cell and cell-matrix contacts, integrins participate in a wide-range of biological interactions including development, tissue repair, angiogenesis, inflammation and hemostasis. [PMID:10402956, PMID:11988479, PMID:9676575]. - integrin alpha + + + optical quality - - - - A protein that is composed of a long N-terminal extracellular domain, a transmembrane domain and a short cytoplasmic C-terminal domain. The N-terminal domain contains beta-propeller repeats (interrupted by an A domain in a subset of integrins alpha), while the C-terminal domain contains a GFFxR motif. - PMID:19693543 - - + - - - - - - - - - - - - - - - - - - - - A protein that is encoded in the genome of Mus musculus. - mouse protein - protein - PR:000029032 - Mus musculus protein + + + quality of a solid - - - - A protein that is encoded in the genome of Mus musculus. - PRO:DAN - - - - - mouse protein - PRO:DAN - - - + - - - - - - - - - - - - - - - - - - - - A protein that is encoded in the genome of Homo sapiens. - human protein - protein - PR:000029067 - Homo sapiens protein + + + quality of a gas - - - - A protein that is encoded in the genome of Homo sapiens. - PRO:DAN - - - - - human protein - PRO:DAN - - - + - - - - - - - - - - - - - - - - - - - - A protein that is encoded in the genome of some Eukaryota. - Eukaryota protein - protein - PR:000036194 - eukaryotic protein + + + A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape. + liquidity + quality + PATO:0001548 + + quality of a liquid - + - A protein that is encoded in the genome of some Eukaryota. - PRO:DAN - - - - - Eukaryota protein - PRO:DAN + A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape. + url:http://www.chemistry-dictionary.com/definition/liquid.php - + - - - A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide. - fam:INS - protein - PR:000045358 - Category=family. - insulin family protein + + + contractility - - - - A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide. - PRO:DAN - - - - - fam:INS - PRO:DAN - - - + - - - - - - - - - - - - - - - - - - - - A material entity that minimally consists of a protein. - protein - protein aggregate - protein complex - protein-containing complex - protein - PR:000050567 - Note: This includes single proteins and derivatives thereof (PR:000000001), protein-containing complexes (GO:0032991), and protein aggregates (PR:000050566). - protein-containing material entity + + + curvature - - - - A material entity that minimally consists of a protein. - PRO:DAN - - - - - protein - PRO:DAN - - - - - protein aggregate - PRO:DAN - - - - - protein complex - PRO:DAN - - - - - protein-containing complex - PRO:DAN - - + - - - - - - - - - - - - - - - - - - - - - An insulin gene translation product that is encoded in the genome of human. - UniProtKB:P01308 - hINS - protein - PR:P01308 - Category=organism-gene. - insulin gene translation product (human) + + + contractile - - - - An insulin gene translation product that is encoded in the genome of human. - PRO:DAN - UniProtKB:P01308 - - - - - hINS - PRO:DNx - - - + - - - - - - - - - - - - - - - - - - - - - A CD4 molecule that is encoded in the genome of human. - UniProtKB:P01730 - T-cell surface antigen T4/Leu-3 (human) - hCD4 - protein - CD4 - PR:P01730 - Category=organism-gene. - T-cell surface glycoprotein CD4 (human) + + + liquid configuration - - - - A CD4 molecule that is encoded in the genome of human. - PRO:DNx - UniProtKB:P01730 - - - - - T-cell surface antigen T4/Leu-3 (human) - UniProtKB:P01730 - - - - - hCD4 - PRO:DNx - - - - - - CD4 - UniProtKB:P01730 - - - + - - - - - - - - - - - - - - - - - - - - - A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of mouse. - UniProtKB:P01731 - CD8a (mouse) - T-cell surface glycoprotein Lyt-2 (mouse) - mCD8A - protein - Cd8a - Lyt-2 - Lyt2 - PR:P01731 - Category=organism-gene. - T-cell surface glycoprotein CD8 alpha chain (mouse) + + + solid configuration - - - - A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of mouse. - OMA:P01731 - PRO:DNx - - - - - CD8a (mouse) - UniProtKB:P01731 - - - - - T-cell surface glycoprotein Lyt-2 (mouse) - UniProtKB:P01731 - - - - - mCD8A - PRO:DNx - - - - - - Cd8a - UniProtKB:P01731 - - - - - - Lyt-2 - UniProtKB:P01731 - - - - - - Lyt2 - UniProtKB:P01731 - - - + - - - - - - - - - - - - - - - - - - - - - A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of human. - UniProtKB:P01732 - CD8a (human) - T-lymphocyte differentiation antigen T8/Leu-2 (human) - hCD8A - protein - CD8A - MAL - PR:P01732 - Category=organism-gene. - T-cell surface glycoprotein CD8 alpha chain (human) + + + radiation quality - - - - A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of human. - PRO:CNA - UniProtKB:P01732 - - - - - CD8a (human) - UniProtKB:P01732 - - - - - T-lymphocyte differentiation antigen T8/Leu-2 (human) - UniProtKB:P01732 - - - - - hCD8A - PRO:DNx - - - - - - CD8A - UniProtKB:P01732 - - - - - - MAL - UniProtKB:P01732 - - - + - - - - - - - - - - - - - - - - - - - - - A transferrin receptor protein 1 that is encoded in the genome of human. - TR (human) - p90 (human) - Reactome:R-HSA-434196 - Reactome:R-HSA-434330 - Reactome:R-HSA-8869124 - Reactome:R-HSA-8961829 - Reactome:R-HSA-917983 - UniProtKB:P02786 - CD71 (human) - T9 (human) - TfR (human) - TfR1 (human) - Trfr (human) - hTFRC - protein - TFRC - PR:P02786 - Category=organism-gene. - transferrin receptor protein 1 (human) + + + invaginated - - - - A transferrin receptor protein 1 that is encoded in the genome of human. - PRO:WCB - UniProtKB:P02786 - - - - - TR (human) - UniProtKB:P02786 - - - - - p90 (human) - UniProtKB:P02786 - - - - - Reactome:R-HSA-434196 - PR:P02786 located_in GO:0030659 - - - - - Reactome:R-HSA-434330 - PR:P02786 located_in GO:0000139 - - - - - Reactome:R-HSA-8869124 - PR:P02786 located_in GO:0030665 - - - - - Reactome:R-HSA-8961829 - PR:P02786 located_in GO:0010008 - - - - - Reactome:R-HSA-917983 - PR:P02786 located_in GO:0005886 - - - - - CD71 (human) - UniProtKB:P02786 - - - - - T9 (human) - UniProtKB:P02786 - - - - - TfR (human) - UniProtKB:P02786 - - - - - TfR1 (human) - UniProtKB:P02786 - - - - - Trfr (human) - UniProtKB:P02786 - - - - - hTFRC - PRO:DNx - - - - - - TFRC - UniProtKB:P02786 - - - + - - - - - - - - - - - - - - - - - - - - - An integrin alpha-M that is encoded in the genome of mouse. - UniProtKB:P05555 - CD11 antigen-like family member B (mouse) - CD11b (mouse) - CR-3 alpha chain (mouse) - cell surface glycoprotein MAC-1 subunit alpha (mouse) - leukocyte adhesion receptor MO1 (mouse) - mITGAM - protein - Itgam - PR:P05555 - Category=organism-gene. - integrin alpha-M (mouse) + + + concave - - - - An integrin alpha-M that is encoded in the genome of mouse. - PRO:DNx - UniProtKB:P05555 - - - - - CD11 antigen-like family member B (mouse) - UniProtKB:P05555 - - - - - CD11b (mouse) - UniProtKB:P05555 - - - - - CR-3 alpha chain (mouse) - UniProtKB:P05555 - - - - - cell surface glycoprotein MAC-1 subunit alpha (mouse) - UniProtKB:P05555 - - - - - leukocyte adhesion receptor MO1 (mouse) - UniProtKB:P05555 - - - - - mITGAM - PRO:DNx - - - - - - Itgam - UniProtKB:P05555 - - - + - - - - - - - - - - - - - - - - - - - - - A T-cell surface glycoprotein CD5 that is encoded in the genome of human. - UniProtKB:P06127 - hCD5 - lymphocyte antigen T1/Leu-1 (human) - protein - CD5 - LEU1 - PR:P06127 - Category=organism-gene. - T-cell surface glycoprotein CD5 (human) + + + cylindrical - - - - A T-cell surface glycoprotein CD5 that is encoded in the genome of human. - PRO:WCB - UniProtKB:P06127 - - - - - hCD5 - PRO:DNx - - - - - - lymphocyte antigen T1/Leu-1 (human) - UniProtKB:P06127 - - - - - CD5 - UniProtKB:P06127 - - - - - - LEU1 - UniProtKB:P06127 - - - + - - - - - - - - - - - - - - - - - - - - - A CD4 molecule that is encoded in the genome of mouse. - UniProtKB:P06332 - CD4 (mouse) - T-cell differentiation antigen L3T4 (mouse) - T-cell surface antigen T4/Leu-3 (mouse) - mCD4 - protein - Cd4 - PR:P06332 - Category=organism-gene. - T-cell surface glycoprotein CD4 (mouse) + + + saccular - - - - A CD4 molecule that is encoded in the genome of mouse. - OMA:P06332 - PRO:DNx - - - - - CD4 (mouse) - UniProtKB:P06332 - - - - - T-cell differentiation antigen L3T4 (mouse) - UniProtKB:P06332 - - - - - T-cell surface antigen T4/Leu-3 (mouse) - UniProtKB:P06332 - - - - - mCD4 - PRO:DNx - - - - - - Cd4 - UniProtKB:P06332 - - - + - - - - - - - - - - - - - - - - - - - - - A CD2 molecule that is encoded in the genome of human. - UniProtKB:P06729 - LFA-2 (human) - LFA-3 receptor (human) - T-cell surface antigen T11/Leu-5 (human) - erythrocyte receptor (human) - hCD2 - rosette receptor (human) - protein - CD2 - SRBC - PR:P06729 - Category=organism-gene. - T-cell surface antigen CD2 (human) + + + cellularity - - - - A CD2 molecule that is encoded in the genome of human. - PRO:CNA - UniProtKB:P06729 - - - - - LFA-2 (human) - UniProtKB:P06729 - - - - - LFA-3 receptor (human) - UniProtKB:P06729 - - - - - T-cell surface antigen T11/Leu-5 (human) - UniProtKB:P06729 - - - - - erythrocyte receptor (human) - UniProtKB:P06729 - - - - - hCD2 - PRO:DNx - - - - - - rosette receptor (human) - UniProtKB:P06729 - - - - - CD2 - UniProtKB:P06729 - - - - - - SRBC - UniProtKB:P06729 - - - + - - - - - - - - - - - - - - - - - - - - - A CD3 epsilon that is encoded in the genome of human. - UniProtKB:P07766 - CD3e (human) - T-cell surface antigen T3/Leu-4 epsilon chain (human) - hCD3E - protein - CD3E - T3E - PR:P07766 - Category=organism-gene. - T-cell surface glycoprotein CD3 epsilon chain (human) + + + multicellular - - - - A CD3 epsilon that is encoded in the genome of human. - PRO:CNA - UniProtKB:P07766 - - - - - CD3e (human) - UniProtKB:P07766 - - - - - T-cell surface antigen T3/Leu-4 epsilon chain (human) - UniProtKB:P07766 - - - - - hCD3E - PRO:DNx - - - - - - CD3E - UniProtKB:P07766 - - - - - - T3E - UniProtKB:P07766 - - - + - - - - - - - - - - - - - - - - - - - - - A CD14 molecule that is encoded in the genome of human. - UniProtKB:P08571 - hCD14 - myeloid cell-specific leucine-rich glycoprotein (human) - protein - CD14 - PR:P08571 - Category=organism-gene. - monocyte differentiation antigen CD14 (human) + + + organismal quality - - - - A CD14 molecule that is encoded in the genome of human. - PRO:WCB - UniProtKB:P08571 - - - - - hCD14 - PRO:DNx - - - - - - myeloid cell-specific leucine-rich glycoprotein (human) - UniProtKB:P08571 - - - - - CD14 - UniProtKB:P08571 - - - + - - - - - - - - - - - - - - - - - - - - - A CD2 molecule that is encoded in the genome of mouse. - UniProtKB:P08920 - CD2 (mouse) - LFA-2 (mouse) - LFA-3 receptor (mouse) - T-cell surface antigen T11/Leu-5 (mouse) - lymphocyte antigen 37 (mouse) - mCD2 - protein - Cd2 - Ly-37 - PR:P08920 - Category=organism-gene. - T-cell surface antigen CD2 (mouse) + + + concavity - - - - A CD2 molecule that is encoded in the genome of mouse. - OMA:P08920 - PRO:DNx - - - - - CD2 (mouse) - UniProtKB:P08920 - - - - - LFA-2 (mouse) - UniProtKB:P08920 - - - - - LFA-3 receptor (mouse) - UniProtKB:P08920 - - - - - T-cell surface antigen T11/Leu-5 (mouse) - UniProtKB:P08920 - - - - - lymphocyte antigen 37 (mouse) - UniProtKB:P08920 - - - - - mCD2 - PRO:DNx - - - - - - Cd2 - UniProtKB:P08920 - - - - - - Ly-37 - UniProtKB:P08920 - - - + - - - - - - - - - - - - - - - - - - - - - A CD14 molecule that is encoded in the genome of mouse. - UniProtKB:P10810 - CD14 (mouse) - mCD14 - myeloid cell-specific leucine-rich glycoprotein (mouse) - protein - Cd14 - PR:P10810 - Category=organism-gene. - monocyte differentiation antigen CD14 (mouse) - - - - - A CD14 molecule that is encoded in the genome of mouse. - OMA:P10810 - PRO:WCB - - - - - CD14 (mouse) - UniProtKB:P10810 - - - - - mCD14 - PRO:DNx - - - - - - myeloid cell-specific leucine-rich glycoprotein (mouse) - UniProtKB:P10810 - - - - - Cd14 - UniProtKB:P10810 - - + + + convex 3-D shape + - + - - - - - - - - - - - - - - - - - - - - - An integrin alpha-M that is encoded in the genome of human. - UniProtKB:P11215 - CD11 antigen-like family member B (human) - CR-3 alpha chain (human) - cell surface glycoprotein MAC-1 subunit alpha (human) - hITGAM - leukocyte adhesion receptor MO1 (human) - neutrophil adherence receptor (human) - protein - CD11B - CR3A - ITGAM - PR:P11215 - Category=organism-gene. - integrin alpha-M (human) + + + branchiness - - - - An integrin alpha-M that is encoded in the genome of human. - PRO:DNx - UniProtKB:P11215 - - - - - CD11 antigen-like family member B (human) - UniProtKB:P11215 - - - - - CR-3 alpha chain (human) - UniProtKB:P11215 - - - - - cell surface glycoprotein MAC-1 subunit alpha (human) - UniProtKB:P11215 - - - - - hITGAM - PRO:DNx - - - - - - leukocyte adhesion receptor MO1 (human) - UniProtKB:P11215 - - - - - neutrophil adherence receptor (human) - UniProtKB:P11215 - - - - - CD11B - UniProtKB:P11215 - - - - - - CR3A - UniProtKB:P11215 - - - - - - ITGAM - UniProtKB:P11215 - - - + - - - - - - - - - - - - - - - - - - - - - A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of human. - UniProtKB:P11836 - B-lymphocyte surface antigen B1 (human) - Bp35 (human) - hMS4A1 - leukocyte surface antigen Leu-16 (human) - membrane-spanning 4-domains subfamily A member 1 (human) - protein - CD20 - MS4A1 - PR:P11836 - Category=organism-gene. - B-lymphocyte antigen CD20 (human) + + + structure, cavities - - - - A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of human. - PRO:WCB - UniProtKB:P11836 - - - - - B-lymphocyte surface antigen B1 (human) - UniProtKB:P11836 - - - - - Bp35 (human) - UniProtKB:P11836 - - - - - hMS4A1 - PRO:DNx - - - - - - leukocyte surface antigen Leu-16 (human) - UniProtKB:P11836 - - - - - membrane-spanning 4-domains subfamily A member 1 (human) - UniProtKB:P11836 - - - - - CD20 - UniProtKB:P11836 - - - - - - MS4A1 - UniProtKB:P11836 - - - + - - - - - - - - - - - - - - - - - - - - - A T-cell surface glycoprotein CD5 that is encoded in the genome of mouse. - UniProtKB:P13379 - CD5 (mouse) - Lyt-1 (mouse) - lymphocyte antigen 1 (mouse) - mCD5 - protein - Cd5 - Ly-1 - PR:P13379 - Category=organism-gene. - T-cell surface glycoprotein CD5 (mouse) + + + dendritic - - - - A T-cell surface glycoprotein CD5 that is encoded in the genome of mouse. - OMA:P13379 - PRO:DNx - - - - - CD5 (mouse) - UniProtKB:P13379 - - - - - Lyt-1 (mouse) - UniProtKB:P13379 - - - - - lymphocyte antigen 1 (mouse) - UniProtKB:P13379 - - - - - mCD5 - PRO:DNx - - - - - - Cd5 - UniProtKB:P13379 - - - - - - Ly-1 - UniProtKB:P13379 - - - + - - - - - - - - - - - - - - - - - - - - - A neural cell adhesion molecule 1 that is encoded in the genome of human. - UniProtKB:P13591 - CD56 (human) - N-CAM-1 (human) - NCAM-1 (human) - hNCAM1 - protein - NCAM - NCAM1 - PR:P13591 - Category=organism-gene. - neural cell adhesion molecule 1 (human) + + + physical quality of a process - - - - A neural cell adhesion molecule 1 that is encoded in the genome of human. - PRO:CNA - UniProtKB:P13591 - - - - - CD56 (human) - UniProtKB:P13591 - - - - - N-CAM-1 (human) - UniProtKB:P13591 - - - - - NCAM-1 (human) - UniProtKB:P13591 - - - - - hNCAM1 - PRO:DNx - - - - - - NCAM - UniProtKB:P13591 - - - - - - NCAM1 - UniProtKB:P13591 - - - + - - - - - - - - - - - - - - - - - - - - - A neural cell adhesion molecule 1 that is encoded in the genome of mouse. - UniProtKB:P13595 - CD56 (mouse) - N-CAM-1 (mouse) - NCAM-1 (mouse) - mNCAM1 - protein - Ncam - Ncam1 - PR:P13595 - Category=organism-gene. - neural cell adhesion molecule 1 (mouse) + + + hollow - - - - A neural cell adhesion molecule 1 that is encoded in the genome of mouse. - OMA:P13595 - PRO:DNx - - - - - CD56 (mouse) - UniProtKB:P13595 - - - - - N-CAM-1 (mouse) - UniProtKB:P13595 - - - - - NCAM-1 (mouse) - UniProtKB:P13595 - - - - - mNCAM1 - PRO:DNx - - - - - - Ncam - UniProtKB:P13595 - - - - - - Ncam1 - UniProtKB:P13595 - - - + - - - - - - - - - - - - - - - - - - - - - A CD19 molecule that is encoded in the genome of human. - UniProtKB:P15391 - B-lymphocyte surface antigen B4 (human) - T-cell surface antigen Leu-12 (human) - differentiation antigen CD19 (human) - hCD19 - protein - CD19 - PR:P15391 - Category=organism-gene. - B-lymphocyte antigen CD19 (human) + + + laminar - - - - B-lymphocyte surface antigen B4 (human) - UniProtKB:P15391 - - - - - T-cell surface antigen Leu-12 (human) - UniProtKB:P15391 - - - - - differentiation antigen CD19 (human) - UniProtKB:P15391 - - - - - hCD19 - PRO:DNx - - - - - - CD19 - UniProtKB:P15391 - - - + - - - - - - - - - - - - - - - - - - - - - An interleukin-7 receptor subunit alpha that is encoded in the genome of human. - UniProtKB:P16871 - CD127 (human) - CDw127 (human) - IL-7 receptor subunit alpha (human) - IL-7R subunit alpha (human) - IL-7R-alpha (human) - IL-7RA (human) - hIL7R - protein - IL7R - PR:P16871 - Category=organism-gene. - interleukin-7 receptor subunit alpha (human) + + + A quality inhering in a bearer by virtue of its constitution. + George Gkoutos + 2010-03-15T04:35:27Z + quality + PATO:0002198 + + quality of a substance - + - An interleukin-7 receptor subunit alpha that is encoded in the genome of human. - PRO:WCB - UniProtKB:P16871 - - - - - CD127 (human) - UniProtKB:P16871 - - - - - CDw127 (human) - UniProtKB:P16871 - - - - - IL-7 receptor subunit alpha (human) - UniProtKB:P16871 - - - - - IL-7R subunit alpha (human) - UniProtKB:P16871 - - - - - IL-7R-alpha (human) - UniProtKB:P16871 - - - - - IL-7RA (human) - UniProtKB:P16871 - - - - - hIL7R - PRO:DNx - - - - - - IL7R - UniProtKB:P16871 - + A quality inhering in a bearer by virtue of its constitution. + PATOC:GVG - + - - - - - - - - - - - - - - - - - - - - - An interleukin-7 receptor subunit alpha that is encoded in the genome of mouse. - UniProtKB:P16872 - CD127 (mouse) - IL-7 receptor subunit alpha (mouse) - IL-7R subunit alpha (mouse) - IL-7R-alpha (mouse) - IL-7RA (mouse) - mIL7R - protein - Il7r - PR:P16872 - Category=organism-gene. - interleukin-7 receptor subunit alpha (mouse) + + + flattened - - - - An interleukin-7 receptor subunit alpha that is encoded in the genome of mouse. - OMA:P16872 - PRO:DNx - - - - - CD127 (mouse) - UniProtKB:P16872 - - - - - IL-7 receptor subunit alpha (mouse) - UniProtKB:P16872 - - - - - IL-7R subunit alpha (mouse) - UniProtKB:P16872 - - - - - IL-7R-alpha (mouse) - UniProtKB:P16872 - - - - - IL-7RA (mouse) - UniProtKB:P16872 - - - - - mIL7R - PRO:DNx - - - - - - Il7r - UniProtKB:P16872 - - - + - - - - - - - - - - - - - - - - - - - - - A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of human. - Reactome:R-HSA-8956511 - UniProtKB:P17542 - Stem cell protein (human) - T-cell leukemia/lymphoma protein 5 (human) - TAL-1 (human) - class A basic helix-loop-helix protein 17 (human) - hTAL1 - protein - BHLHA17 - SCL - TAL1 - TCL5 - PR:P17542 - Category=organism-gene. - T-cell acute lymphocytic leukemia protein 1 (human) + + + grooved - - - - A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of human. - PRO:DNx - UniProtKB:P17542 - - - - - Reactome:R-HSA-8956511 - PR:P17542 located_in GO:0005654 - - - - - Stem cell protein (human) - UniProtKB:P17542 - - - - - T-cell leukemia/lymphoma protein 5 (human) - UniProtKB:P17542 - - - - - TAL-1 (human) - UniProtKB:P17542 - - - - - class A basic helix-loop-helix protein 17 (human) - UniProtKB:P17542 - - - - - hTAL1 - PRO:DNx - - - - - - BHLHA17 - UniProtKB:P17542 - - - - - - SCL - UniProtKB:P17542 - - - - - - TAL1 - UniProtKB:P17542 - - - - - - TCL5 - UniProtKB:P17542 - - - + - - - - - - - - - - - - - - - - - - - - - A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of mouse. - UniProtKB:P19437 - B-cell differentiation antigen Ly-44 (mouse) - CD20 (mouse) - lymphocyte antigen 44 (mouse) - mMS4A1 - membrane-spanning 4-domains subfamily A member 1 (mouse) - protein - Cd20 - Ly-44 - Ms4a1 - Ms4a2 - PR:P19437 - Category=organism-gene. - B-lymphocyte antigen CD20 (mouse) + + + 3-D shape - - - - A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of mouse. - OMA:P19437 - PRO:DNx - - - - - B-cell differentiation antigen Ly-44 (mouse) - UniProtKB:P19437 - - - - - CD20 (mouse) - UniProtKB:P19437 - - - - - lymphocyte antigen 44 (mouse) - UniProtKB:P19437 - - - - - mMS4A1 - PRO:DNx - - - - - - membrane-spanning 4-domains subfamily A member 1 (mouse) - UniProtKB:P19437 - - - - - Cd20 - UniProtKB:P19437 - - - - - - Ly-44 - UniProtKB:P19437 - - - - - - Ms4a1 - UniProtKB:P19437 - - - - - - Ms4a2 - UniProtKB:P19437 - - - + - - - - - - - - - - - - - - - - - - - - - A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of mouse. - UniProtKB:P22091 - Stem cell protein (mouse) - TAL-1 (mouse) - mTAL1 - protein - Scl - Tal-1 - Tal1 - PR:P22091 - Category=organism-gene. - T-cell acute lymphocytic leukemia protein 1 homolog (mouse) + + + + tubular - - - - A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of mouse. - OMA:P22091 - PRO:DNx - - - - - Stem cell protein (mouse) - UniProtKB:P22091 - - - - - TAL-1 (mouse) - UniProtKB:P22091 - - - - - mTAL1 - PRO:DNx - - - - - - Scl - UniProtKB:P22091 - - - - - - Tal-1 - UniProtKB:P22091 - - - - - - Tal1 - UniProtKB:P22091 - - - + - - - - - - - - - - - - - - - - - - - - - A CD3 epsilon that is encoded in the genome of mouse. - UniProtKB:P22646 - CD3e (mouse) - T-cell surface antigen T3/Leu-4 epsilon chain (mouse) - mCD3E - protein - Cd3e - PR:P22646 - Category=organism-gene. - T-cell surface glycoprotein CD3 epsilon chain (mouse) + + + acinar - - - - A CD3 epsilon that is encoded in the genome of mouse. - OMA:P22646 - PRO:DNx - - - - - CD3e (mouse) - UniProtKB:P22646 - - - - - T-cell surface antigen T3/Leu-4 epsilon chain (mouse) - UniProtKB:P22646 - - - - - mCD3E - PRO:DNx - - - - - - Cd3e - UniProtKB:P22646 - - - + - - - - - - - - - - - - - - - - - - - - - A CD19 molecule that is encoded in the genome of mouse. - UniProtKB:P25918 - CD19 (mouse) - differentiation antigen CD19 (mouse) - mCD19 - protein - Cd19 - PR:P25918 - Category=organism-gene. - B-lymphocyte antigen CD19 (mouse) + + + collagenous - - - - A CD19 molecule that is encoded in the genome of mouse. - OMA:P25918 - PRO:DNx - - - - - CD19 (mouse) - UniProtKB:P25918 - - - - - differentiation antigen CD19 (mouse) - UniProtKB:P25918 - - - - - mCD19 - PRO:DNx - - - - - - Cd19 - UniProtKB:P25918 - - - + - - - - - - - - - - - - - - - - - - - - - A CD34 molecule that is encoded in the genome of human. - UniProtKB:P28906 - hCD34 - protein - CD34 - PR:P28906 - Category=organism-gene. - hematopoietic progenitor cell antigen CD34 (human) + + + distensible + + + + + + + + + distensibility - - - - hCD34 - PRO:DNx - - - - - - CD34 - UniProtKB:P28906 - - - + - + - + - - + + + + + + - - + + - - + + + + + + + + + + + + + + - A cadherin-5 that is encoded in the genome of human. - UniProtKB:P33151 - 7B4 antigen (human) - CD144 (human) - VE-cadherin (human) - hCDH5 - vascular endothelial cadherin (human) + An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof. + natural protein + native protein protein - CDH5 - PR:P33151 - Category=organism-gene. - cadherin-5 (human) + PR:000000001 + The definition above excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to CHEBI:36080. Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB]. + protein - + - A cadherin-5 that is encoded in the genome of human. + An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof. + PRO:DAN PRO:WCB - UniProtKB:P33151 - + - 7B4 antigen (human) - UniProtKB:P33151 + natural protein + PRO:DAN - - - CD144 (human) - UniProtKB:P33151 + + + native protein + IEDB:BP + + + + + + + + + A protein that is a translation product of the human FGF8 gene or a 1:1 ortholog thereof. + FGF-8 + FGF8 + androgen-induced growth factor + protein + AIGF + HBGF-8 + heparin-binding growth factor 8 + PR:000007499 + Category=gene. + fibroblast growth factor 8 + - - - VE-cadherin (human) - UniProtKB:P33151 + + + A protein that is a translation product of the human FGF8 gene or a 1:1 ortholog thereof. + PRO:DNx - + - hCDH5 + FGF8 PRO:DNx - - - vascular endothelial cadherin (human) - UniProtKB:P33151 - - - + - CDH5 - UniProtKB:P33151 + AIGF - + - - - - - - - - - - - - - - - - - - - - - A lymphocyte antigen 6G that is encoded in the genome of mouse. - UniProtKB:P35461 - Ly-6G (mouse) - Ly-6G.1 (mouse) - mLy6g + + + + A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof. + HHG-1 + SHH + Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains + ShhNC protein - Ly6g - PR:P35461 - Category=organism-gene. - lymphocyte antigen 6G (mouse) + Hhg1 + PR:000014841 + Category=gene. + sonic hedgehog protein - + - A lymphocyte antigen 6G that is encoded in the genome of mouse. - PRO:CNA - UniProtKB:P35461 - - - - - Ly-6G (mouse) - UniProtKB:P35461 - - - - - Ly-6G.1 (mouse) - UniProtKB:P35461 + A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof. + PRO:DNx - + - mLy6g + SHH PRO:DNx - + - Ly6g - UniProtKB:P35461 + Hhg1 - + - - - - - - - - - - - - - - + + - - - - - A vascular endothelial growth factor receptor 2 that is encoded in the genome of mouse. - UniProtKB:P35918 - CD309 (mouse) - FLK-1 (mouse) - VEGFR-2 (mouse) - fetal liver kinase 1 (mouse) - kinase NYK (mouse) - mKDR - protein-tyrosine kinase receptor flk-1 (mouse) + + + + + An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds. + peptide + polypeptide protein - Flk-1 - Flk1 - Kdr - PR:P35918 - Category=organism-gene. - vascular endothelial growth factor receptor 2 (mouse) + PR:000018263 + Category=external. + amino acid chain - + - A vascular endothelial growth factor receptor 2 that is encoded in the genome of mouse. - OMA:P35918 - PRO:DNx - - - - - CD309 (mouse) - UniProtKB:P35918 - - - - - FLK-1 (mouse) - UniProtKB:P35918 - - - - - VEGFR-2 (mouse) - UniProtKB:P35918 - - - - - fetal liver kinase 1 (mouse) - UniProtKB:P35918 - - - - - kinase NYK (mouse) - UniProtKB:P35918 - - - - - mKDR - PRO:DNx - - - - - - protein-tyrosine kinase receptor flk-1 (mouse) - UniProtKB:P35918 - - - - - Flk-1 - UniProtKB:P35918 - + An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds. + PRO:DAN + PRO:JSG - - - Flk1 - UniProtKB:P35918 - + + + peptide + PRO:DAN - - - Kdr - UniProtKB:P35918 - + + + polypeptide + PRO:DAN - + - + - + @@ -226490,200 +41024,74 @@ The modern definition of neurosecretion has evolved to include the release of an - - + - A vascular endothelial growth factor receptor 2 that is encoded in the genome of human. - DTO:03100560 - UniProtKB:P35968 - CD309 (human) - FLK-1 (human) - VEGFR-2 (human) - fetal liver kinase 1 (human) - hKDR - kinase insert domain receptor (human) - protein-tyrosine kinase receptor flk-1 (human) + A protein that is encoded in the genome of Homo sapiens. + human protein protein - FLK1 - KDR - VEGFR2 - PR:P35968 - Category=organism-gene. - vascular endothelial growth factor receptor 2 (human) + PR:000029067 + Homo sapiens protein - + - A vascular endothelial growth factor receptor 2 that is encoded in the genome of human. - PRO:WCB - UniProtKB:P35968 - - - - - CD309 (human) - UniProtKB:P35968 - - - - - FLK-1 (human) - UniProtKB:P35968 - - - - - VEGFR-2 (human) - UniProtKB:P35968 - - - - - fetal liver kinase 1 (human) - UniProtKB:P35968 + A protein that is encoded in the genome of Homo sapiens. + PRO:DAN - + - hKDR - PRO:DNx + human protein + PRO:DAN - - - - kinase insert domain receptor (human) - UniProtKB:P35968 - - - - - protein-tyrosine kinase receptor flk-1 (human) - UniProtKB:P35968 - - - - - FLK1 - UniProtKB:P35968 - - - - - - KDR - UniProtKB:P35968 - - - - - - VEGFR2 - UniProtKB:P35968 - - - + - + - + - + - - + + - + - A fibroblast growth factor 8 that is encoded in the genome of mouse. - UniProtKB:P37237 - AIGF (mouse) - FGF-8 (mouse) - androgen-induced growth factor (mouse) - mFGF8 + A protein that is encoded in the genome of some Eukaryota. + Eukaryota protein protein - Aigf - Fgf8 - HBGF-8 (mouse) - heparin-binding growth factor 8 (mouse) - PR:P37237 - Category=organism-gene. - fibroblast growth factor 8 (mouse) + PR:000036194 + eukaryotic protein - + - A fibroblast growth factor 8 that is encoded in the genome of mouse. - OMA:P37237 - PRO:DNx - - - - - AIGF (mouse) - UniProtKB:P37237 - - - - - FGF-8 (mouse) - UniProtKB:P37237 - - - - - androgen-induced growth factor (mouse) - UniProtKB:P37237 + A protein that is encoded in the genome of some Eukaryota. + PRO:DAN - + - mFGF8 - PRO:DNx - - - - - - Aigf - UniProtKB:P37237 - - - - - - Fgf8 - UniProtKB:P37237 - - - - - - HBGF-8 (mouse) - UniProtKB:P37237 - - - - - heparin-binding growth factor 8 (mouse) - UniProtKB:P37237 + Eukaryota protein + PRO:DAN @@ -226710,6 +41118,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + A fibroblast growth factor 8 that is encoded in the genome of human. HBGF-8 (human) heparin-binding growth factor 8 (human) @@ -226779,82 +41193,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - A cadherin-5 that is encoded in the genome of mouse. - UniProtKB:P55284 - CD144 (mouse) - VE-cadherin (mouse) - mCDH5 - vascular endothelial cadherin (mouse) - protein - Cdh5 - PR:P55284 - Category=organism-gene. - cadherin-5 (mouse) - - - - - A cadherin-5 that is encoded in the genome of mouse. - OMA:P55284 - PRO:DNx - - - - - CD144 (mouse) - UniProtKB:P55284 - - - - - VE-cadherin (mouse) - UniProtKB:P55284 - - - - - mCDH5 - PRO:DNx - - - - - - vascular endothelial cadherin (mouse) - UniProtKB:P55284 - - - - - Cdh5 - UniProtKB:P55284 - - - - - @@ -226877,6 +41215,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + A sonic hedgehog protein that is encoded in the genome of human. UniProtKB:Q15465 HHG-1 (human) @@ -226931,282 +41275,71 @@ The modern definition of neurosecretion has evolved to include the release of an - + - - - - - - - - - - - - - - - - - - - - - A sonic hedgehog protein that is encoded in the genome of mouse. - UniProtKB:Q62226 - HHG-1 (mouse) - SHH (mouse) - Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (mouse) - ShhNC (mouse) - mSHH - protein - Hhg1 - Shh - PR:Q62226 - Category=organism-gene. - sonic hedgehog protein (mouse) + + + system - - - - A sonic hedgehog protein that is encoded in the genome of mouse. - OMA:Q62226 - PRO:DNx - - - - - HHG-1 (mouse) - UniProtKB:Q62226 - - - - - SHH (mouse) - UniProtKB:Q62226 - - - - - Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (mouse) - UniProtKB:Q62226 - - - - - ShhNC (mouse) - UniProtKB:Q62226 - - - - - mSHH - PRO:DNx - - - - - - Hhg1 - UniProtKB:Q62226 - - - - - - Shh - UniProtKB:Q62226 - - - + - - - - - - - - - - - - - - - - - - - - - A transferrin receptor protein 1 that is encoded in the genome of mouse. - UniProtKB:Q62351 - CD71 (mouse) - TfR (mouse) - TfR1 (mouse) - mTFRC - protein - TR (mouse) - Tfrc - Trfr - PR:Q62351 - Category=organism-gene. - transferrin receptor protein 1 (mouse) + + + protein-coding + sequence + SO:0000010 + Category=external. + protein_coding - - - - A transferrin receptor protein 1 that is encoded in the genome of mouse. - OMA:Q62351 - PRO:DNx - - - - - CD71 (mouse) - UniProtKB:Q62351 - - - - - TfR (mouse) - UniProtKB:Q62351 - - - - - TfR1 (mouse) - UniProtKB:Q62351 - - - - - mTFRC - PRO:DNx - - - - - - TR (mouse) - UniProtKB:Q62351 - - - - - Tfrc - UniProtKB:Q62351 - - - - - - Trfr - UniProtKB:Q62351 - - - + - - - - - - - - - - - - - - - - - - - - - A CD34 molecule that is encoded in the genome of mouse. - UniProtKB:Q64314 - CD34 (mouse) - mCD34 - protein - Cd34 - PR:Q64314 - Category=organism-gene. - hematopoietic progenitor cell antigen CD34 (mouse) + + A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions. + sequence + SO:0000704 + gene - + - A CD34 molecule that is encoded in the genome of mouse. - OMA:Q64314 - PRO:DNx - - - - - CD34 (mouse) - UniProtKB:Q64314 - - - - - mCD34 - PRO:DNx - - - - - - Cd34 - UniProtKB:Q64314 - + A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions. + SO:immuno_workshop - + - - - A material entity consisting of multiple components that are causally integrated. - May be replaced by a BFO class, as discussed in http://www.jbiomedsem.com/content/4/1/43 - - http://www.jbiomedsem.com/content/4/1/43 - system + + + + + + + + + protein coding gene + sequence + SO:0001217 + protein_coding_gene - - - - - - An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity. - - - - BFO:0000003 uberon UBERON:0000000 - processual entity @@ -227219,56 +41352,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - FBbt:00005157 - chemosensory sensory organ - uberon - UBERON:0000005 - - - chemosensory organ - - - - - chemosensory sensory organ - FBbt:00005157 - - - - @@ -227310,6 +41393,8 @@ The modern definition of neurosecretion has evolved to include the release of an Mammals, birds, reptiles and amphibians have a pancreas with similar histology and mode of development, while in some fish, the islet cells are segregated as Brockmann bodies.[well established][VHOG] A primitive exocrine pancreas can be found in holocephalan cartilaginous fish; a pancreatic duct directly ending in the gut lumen is connected to a glandular structure made of exocrine cells and associated with cell islets, which comprises three different hormone-producing cell types: insulin, somatostatin and glucagon (Yui and Fujita, 1986) + + AAO:0010406 BTO:0000991 CALOHA:TS-0741 @@ -227325,7 +41410,6 @@ The modern definition of neurosecretion has evolved to include the release of an NCIT:C12608 UMLS:C0022131 VHOG:0000646 - Wikipedia:Islets_of_Langerhans XAO:0000159 pancreatic insula pancreatic islet @@ -227339,7 +41423,7 @@ The modern definition of neurosecretion has evolved to include the release of an islet of Langerhans - http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png + http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png @@ -227350,7 +41434,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:16417468 + @@ -227361,7 +41445,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:16417468 + @@ -227372,7 +41456,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:16417468 + @@ -227386,26 +41470,26 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure which consists of glands developed from pancreatic ducts in the larvae and secrete insulin.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010406 - AAO - AAO:BJB + AAO + AAO:BJB Mammals, birds, reptiles and amphibians have a pancreas with similar histology and mode of development, while in some fish, the islet cells are segregated as Brockmann bodies.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000646 - VHOG + VHOG + PMID:7600975 Slack JMW, Developmental biology of the pancreas. Development (1995) - http://bgee.unil.ch/ A primitive exocrine pancreas can be found in holocephalan cartilaginous fish; a pancreatic duct directly ending in the gut lumen is connected to a glandular structure made of exocrine cells and associated with cell islets, which comprises three different hormone-producing cell types: insulin, somatostatin and glucagon (Yui and Fujita, 1986) - PMID:16417468 + @@ -227452,13 +41536,14 @@ The modern definition of neurosecretion has evolved to include the release of an A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]. submucosal + + + BTO:0002107 FMA:85391 FMA:85392 NCIT:C13167 - SCTID:68439008 UMLS:C0225344 - Wikipedia:Submucosa organ submucosa region of submucosa submucosa of organ @@ -227471,14 +41556,14 @@ The modern definition of neurosecretion has evolved to include the release of an submucosa - http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png - http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png + http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png + http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]. - Wikipedia:Submucosa + @@ -227528,6 +41613,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -227542,6 +41628,10 @@ The modern definition of neurosecretion has evolved to include the release of an The peripheral nervous system (PNS) is the part of the nervous system connected to the CNS which contains cranial nerves III - XII, spinal, peripheral and autonomic nerves. (CUMBO) (...) specific vertebrate traits within the chordate phylum such as skeletal tissues, PNS, and spectacular head and brain development, are linked to the NC (neural crest) and its derivatives.[well established][VHOG] PNS + + + + AAO:0000429 BAMS:PNS BILA:0000081 @@ -227561,12 +41651,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D017933 MIAA:0000338 NCIT:C12465 - SCTID:362292005 TAO:0000142 UMLS:C0206417 UMLS:C1305921 VHOG:0000399 - Wikipedia:Peripheral_nervous_system XAO:0000178 ZFA:0000142 neuronames:3232 @@ -227581,13 +41669,13 @@ The modern definition of neurosecretion has evolved to include the release of an peripheral nervous system - http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png + http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png - cjm + cjm @@ -227599,47 +41687,52 @@ The modern definition of neurosecretion has evolved to include the release of an Nervous structures including ganglia outside of the central nervous system. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000142 - TAO - ZFIN:curator + TAO + ZFIN:curator Part of nervous system in which nerves extend throughout the body outside of the brain and spinal cord.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000429 - AAO - AAO:BJB + AAO + AAO:BJB The peripheral nervous system (PNS) is the part of the nervous system connected to the CNS which contains cranial nerves III - XII, spinal, peripheral and autonomic nerves. (CUMBO) - http://neurolex.org/wiki/Cumbo_terms + (...) specific vertebrate traits within the chordate phylum such as skeletal tissues, PNS, and spectacular head and brain development, are linked to the NC (neural crest) and its derivatives.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000399 - VHOG + VHOG + DOI:10.1007/978-0-387-46954-6_6 Dupin E, Creuzet S, Le Douarin NM, The contribution of the neural crest to the vertebrate body. Advances in experimental medicine and biology (2006) - http://bgee.unil.ch/ PNS - + UMLS:C0206417 BIRNLEX:1111 + + + + + UMLS:C0206417 ncithesaurus:Peripheral_Nervous_System @@ -227652,18 +41745,18 @@ The modern definition of neurosecretion has evolved to include the release of an pars peripherica + FMA:9903 - FMA:TA - Wikipedia:Peripheral_nervous_system + FMA:TA systema nervosum periphericum + FMA:9903 - FMA:TA - Wikipedia:Peripheral_nervous_system + FMA:TA @@ -227672,6 +41765,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -227690,6 +41784,10 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the autonomic nervous system which chiefly contains adrenergic fibres and tends to control and reduce secretions, decrease the contractility and hence the tone of smooth muscles and provoke the contraction of blood vessels. Essentially, it consists of preganglionic fibres from the thoracic and upper lumbar parts of the spinal cord. These fibres, by means of delicate rami communicantes, cross over to ganglia sited in a pair of ganglionated cords on each side of the vertebral column or to more peripheral ganglia. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] The autonomic nervous system is composed of three divisions: the sympathetic division, the parasympathetic division, and the enteric division. (...) In ray-finned teleost fishes, a sympathetic chain is present, and dual innervation of additional organs can be observed. A similar pattern can be found in amphibians (...). The evolution of the autonomic nervous system has been quite conservative, especially in the tetrapod lineage.[well established][VHOG] has developmental contribution from NC in verteberates (https://github.com/obophenotype/uberon/wiki/The-neural-crest) + + + + AAO:0010487 BIRNLEX:2516 BTO:0001832 @@ -227704,12 +41802,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D013564 MIAA:0000100 NCIT:C12795 - SCTID:362484004 TAO:0001576 UMLS:C0039044 UMLS:C1269646 VHOG:0000384 - Wikipedia:Sympathetic_nervous_system ZFA:0001576 pars sympathica divisionis autonomici systematis nervosi sympathetic nervous system @@ -227722,13 +41818,13 @@ The modern definition of neurosecretion has evolved to include the release of an sympathetic nervous system - http://upload.wikimedia.org/wikipedia/commons/7/77/Gray838.png + http://upload.wikimedia.org/wikipedia/commons/7/77/Gray838.png - cjm + cjm @@ -227739,8 +41835,8 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA - MA + FMA + MA ZFA-modified-from-isa @@ -227753,35 +41849,40 @@ The modern definition of neurosecretion has evolved to include the release of an Part of the autonomic nervous system which has opposing physiological effects of the parasympathetic nervous system. Examples include increasing the heart rate or constricting the blood vessels.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010487 - AAO - AAO:BJB + AAO + AAO:BJB The part of the autonomic nervous system which chiefly contains adrenergic fibres and tends to control and reduce secretions, decrease the contractility and hence the tone of smooth muscles and provoke the contraction of blood vessels. Essentially, it consists of preganglionic fibres from the thoracic and upper lumbar parts of the spinal cord. These fibres, by means of delicate rami communicantes, cross over to ganglia sited in a pair of ganglionated cords on each side of the vertebral column or to more peripheral ganglia. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000384 - VHOG - http://bgee.unil.ch/ + VHOG + The autonomic nervous system is composed of three divisions: the sympathetic division, the parasympathetic division, and the enteric division. (...) In ray-finned teleost fishes, a sympathetic chain is present, and dual innervation of additional organs can be observed. A similar pattern can be found in amphibians (...). The evolution of the autonomic nervous system has been quite conservative, especially in the tetrapod lineage.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000384 - VHOG + VHOG + ISBN:978-0471210054 Butler AB and Hodos W, Comparative vertebrate neuroanatomy: Evolution and Adaptation (2005) p.461-463 - http://bgee.unil.ch/ UMLS:C0039044 BIRNLEX:2516 + + + + + UMLS:C0039044 ncithesaurus:Sympathetic_Nervous_System @@ -227795,14 +41896,14 @@ The modern definition of neurosecretion has evolved to include the release of an pars sympathica divisionis autonomici systematis nervosi FMA:9906 - FMA:TA + FMA:TA pars sympathica divisionis autonomici systematis nervosi - Wikipedia:Sympathetic_nervous_system + @@ -227811,7 +41912,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -227836,6 +41936,8 @@ The modern definition of neurosecretion has evolved to include the release of an Note the distinction between the entire skin of the body, of which there is only 1 in an organism, and zones of skin, of which there can be many. Examples: skin of knee (...) it is well-established that neural crest cells contribute to both the dermal skeleton (craniofacial bone, teeth, and the caudal fin rays of teleosts) and the integument, including craniofacial dermis and all pigment cells outside the retina (...).[well established][VHOG] we assume that mouse, HOG and GAID all mean zone of skin when they say skin. We also choose skin as an exact synonym, as it is more intuitive + + EHDAA2:0001844 EHDAA:6530 EMAPA:17525 @@ -227846,9 +41948,8 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000284 MESH:D012867 MIAA:0000284 - SCTID:20795001 + OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA VHOG:0000860 - Wikipedia:Skin portion of skin region of skin skin @@ -227858,31 +41959,31 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0000014 zone of skin - http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg - http://upload.wikimedia.org/wikipedia/commons/e/e8/HumanSkinDiagram.jpg + http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg + http://upload.wikimedia.org/wikipedia/commons/e/e8/HumanSkinDiagram.jpg - FMA + FMA Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis. - Wikipedia:Skin - http://orcid.org/0000-0002-6601-2165 + + (...) it is well-established that neural crest cells contribute to both the dermal skeleton (craniofacial bone, teeth, and the caudal fin rays of teleosts) and the integument, including craniofacial dermis and all pigment cells outside the retina (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000860 - VHOG + VHOG + DOI:10.1111/j.1469-7580.2008.01043.x Vickaryous MK, Sire JY, The integumentary skeleton of tetrapods: origin, evolution, and development. J Anat (2009) - http://bgee.unil.ch/ @@ -227898,16 +41999,12 @@ The modern definition of neurosecretion has evolved to include the release of an A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures. - - - AEO:0000192 CARO:0000010 FMA:50705 anatomical boundary uberon UBERON:0000015 - Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms. non-material anatomical boundary @@ -227999,6 +42096,8 @@ The modern definition of neurosecretion has evolved to include the release of an The zebrafish endocrine pancreas is composed of small groups of islet cells that are distributed throughout the exocrine pancreas. The islet cells produce insulin, glucagon and somatostatin.[TAO] In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG] endocrine and exocrine pancreas are not co-associated in hagfishes or lampreys + + BTO:0000650 CALOHA:TS-1302 EFO:0002542 @@ -228007,10 +42106,8 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:16018 MA:0001582 NCIT:C32509 - SCTID:361339003 TAO:0001260 VHOG:0000049 - Wikipedia:Islets_of_Langerhans ZFA:0001260 endocrine pancreas pars endocrina pancreatis @@ -228030,7 +42127,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -228041,9 +42138,9 @@ The modern definition of neurosecretion has evolved to include the release of an - AAO - FMA - XAO + AAO + FMA + XAO @@ -228054,7 +42151,7 @@ The modern definition of neurosecretion has evolved to include the release of an - GO + GO @@ -228065,7 +42162,7 @@ The modern definition of neurosecretion has evolved to include the release of an - GO + GO @@ -228076,49 +42173,49 @@ The modern definition of neurosecretion has evolved to include the release of an - GO + GO The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin. + GO:GO - http://orcid.org/0000-0002-6601-2165 The part of the pancreas that acts as an endocrine gland, consisting of the islets of Langerhans, which secrete insulin and other hormones. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000049 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/Pancreas + VHOG + + The zebrafish endocrine pancreas is composed of small groups of islet cells that are distributed throughout the exocrine pancreas. The islet cells produce insulin, glucagon and somatostatin.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001260 - TAO - ZFIN:curator + TAO + ZFIN:curator In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000049 - VHOG + VHOG + DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007) - http://bgee.unil.ch/ endocrine and exocrine pancreas are not co-associated in hagfishes or lampreys - PMID:20959416 + @@ -228182,6 +42279,9 @@ The modern definition of neurosecretion has evolved to include the release of an The exocrine pancreas is composed of acinar epithelial cells and ductal epithelium that manufacture the proteolytic enzymes and bicarbonate required for digestion.[TAO] The part of the pancreas that acts as an exocrine gland, consisting of the pancreatic acini, which produce pancreatic juice and secrete it into the intestine to aid in protein digestion. [TFD][VHOG] In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG] + + + AAO:0010407 BTO:0000434 CALOHA:TS-1241 @@ -228191,11 +42291,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002415 MESH:D046790 NCIT:C32546 - SCTID:248202004 TAO:0001249 UMLS:C0553695 VHOG:0000048 - Wikipedia:Exocrine_component_of_pancreas XAO:0000137 ZFA:0001249 exocrine pancreas @@ -228215,37 +42313,37 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]. + GOC:GO - http://orcid.org/0000-0002-6601-2165 The exocrine pancreas is composed of acinar epithelial cells and ductal epithelium that manufacture the proteolytic enzymes and bicarbonate required for digestion.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001249 - TAO - ZFIN:curator + TAO + ZFIN:curator The part of the pancreas that acts as an exocrine gland, consisting of the pancreatic acini, which produce pancreatic juice and secrete it into the intestine to aid in protein digestion. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000048 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/Pancreas + VHOG + + In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000048 - VHOG + VHOG + DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007) - http://bgee.unil.ch/ @@ -228276,6 +42374,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -228291,12 +42390,11 @@ The modern definition of neurosecretion has evolved to include the release of an A light sensing organ composed of ommatidia. The term compound eye is sometimes used for the multi-unit eyes of annelids, bivalves, echinoderms. We follow Richter et al and restrict this class to the arthropod structure for these structures + BTO:0001921 FBbt:00004508 HAO:0000217 - IDOMAL:0002421 TGMA:0000024 - Wikipedia:Compound_eye uberon Facettenauge Komplexauge @@ -228319,26 +42417,20 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:21062451 + A light sensing organ composed of ommatidia. + FB:gg - Wikipedia:Compound_eye The term compound eye is sometimes used for the multi-unit eyes of annelids, bivalves, echinoderms. We follow Richter et al and restrict this class to the arthropod structure for these structures - PMID:21062451 - - - - - IDOMAL:0002421 - https://orcid.org/0000-0003-4423-4370 + @@ -228415,6 +42507,9 @@ The modern definition of neurosecretion has evolved to include the release of an The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] FMA distinguishes Eye (subdivision of face) which has its parts an Eyeball (organ), as well as other structures, and the orbit of skull. MA includes eyelid, conjunctiva and lacrimal apparatus as part of MA:eye - consistent with FMA - so we can infer that MA:eye is more like FMA:eye than FMA:eyeball. For other AOs this distinction is less meaningful - e.g. ZFA has no eyelid; XAO has no eyelid, but it has conjuctiva, which is considered part of the xao:eye. GO considers eyelid development part of eye development. See also notes on optic nerve - XAO, AAO and BTO consider this part of the eye. MA considers the eye muscles part of the eye, whereas FMA has a class 'orbital content' for this eye + + + AAO:0010340 BIRNLEX:1169 BTO:0004688 @@ -228424,7 +42519,7 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:54448 MA:0000261 NCIT:C12401 - SCTID:181143004 + OpenCyc:Mx8Ngx4rwKSh9pwpEbGdrcN5Y29ycB4rvVil5pwpEbGdrcN5Y29ycB4rvViTvpwpEbGdrcN5Y29ycA TAO:0000107 UMLS:C0015392 UMLS:C1280202 @@ -228453,7 +42548,7 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional @@ -228464,39 +42559,39 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/The-neural-crest + An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid. + GO:0043010 - https://orcid.org/0000-0002-6601-2165 A cavitated compound organ that transduces light waves into neural signals.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000107 - TAO - TAO:wd + TAO + TAO:wd The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000275 - VHOG + VHOG + DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007) - http://bgee.unil.ch/ FMA distinguishes Eye (subdivision of face) which has its parts an Eyeball (organ), as well as other structures, and the orbit of skull. MA includes eyelid, conjunctiva and lacrimal apparatus as part of MA:eye - consistent with FMA - so we can infer that MA:eye is more like FMA:eye than FMA:eyeball. For other AOs this distinction is less meaningful - e.g. ZFA has no eyelid; XAO has no eyelid, but it has conjuctiva, which is considered part of the xao:eye. GO considers eyelid development part of eye development. See also notes on optic nerve - XAO, AAO and BTO consider this part of the eye. MA considers the eye muscles part of the eye, whereas FMA has a class 'orbital content' for this - FMA + FMA @@ -228509,6 +42604,11 @@ The modern definition of neurosecretion has evolved to include the release of an UMLS:C0015392 BIRNLEX:1169 + + + + + UMLS:C0015392 ncithesaurus:Eye @@ -228522,7 +42622,7 @@ The modern definition of neurosecretion has evolved to include the release of an regio orbitalis FMA:54448 - FMA:TA + FMA:TA @@ -228530,7 +42630,7 @@ The modern definition of neurosecretion has evolved to include the release of an eyes TAO:0000107 - + @@ -228576,6 +42676,8 @@ The modern definition of neurosecretion has evolved to include the release of an An organ that is capable of transducing sensory stimulus to the nervous system. + + AEO:0000094 BSA:0000121 BTO:0000202 @@ -228589,7 +42691,6 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000017 MESH:D012679 NCIT:C33224 - SCTID:244485009 UMLS:C0935626 VHOG:0001407 WBbt:0006929 @@ -228607,14 +42708,14 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0000020 sense organ - http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png + http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png An organ that is capable of transducing sensory stimulus to the nervous system. - https://github.com/obophenotype/uberon/issues/549 - https://orcid.org/0000-0002-6601-2165 + + @@ -228626,37 +42727,37 @@ The modern definition of neurosecretion has evolved to include the release of an organ of sense organ system - OBOL:accepted + OBOL:accepted organ of sensory organ system - OBOL:accepted + OBOL:accepted organ of sensory system - OBOL:accepted + OBOL:accepted sense organ system organ - OBOL:automatic + OBOL:automatic sensory organ system organ - OBOL:automatic + OBOL:automatic sensory system organ - OBOL:accepted + OBOL:accepted @@ -228714,7 +42815,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any hollow cylindrical anatomical structure containing a lumen through which substances are transported. - http://orcid.org/0000-0002-6601-2165 + @@ -228734,6 +42835,8 @@ The modern definition of neurosecretion has evolved to include the release of an Organ or organ part that is attached to the body of an organism. For example a limb[GO, modified][GO:0048736]. appendicular this is currently a subtype of organism subdivision - which would exclude feathers + + AEO:0000193 BILA:0000018 BTO:0001492 @@ -228748,9 +42851,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D005121 MIAA:0000023 NCIT:C61460 + OpenCyc:Mx4rvViC-JwpEbGdrcN5Y29ycA UMLS:C0598782 VSAO:0000075 - Wikipedia:Appendage XAO:0000218 uberon appendages @@ -228785,7 +42888,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37283 - MA:th + MA:th @@ -228798,7 +42901,7 @@ The modern definition of neurosecretion has evolved to include the release of an appendages XAO:0000218 - + @@ -228838,12 +42941,13 @@ The modern definition of neurosecretion has evolved to include the release of an A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions. + + + BTO:0002330 FMA:62517 NCIT:C32918 - SCTID:298225002 UMLS:C1179187 - Wikipedia:Lamina_propria lamina propria mucosa lamina propria mucosae uberon @@ -228851,13 +42955,13 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0000030 lamina propria - https://upload.wikimedia.org/wikipedia/commons/f/fb/GI_Organization.svg + https://upload.wikimedia.org/wikipedia/commons/f/fb/GI_Organization.svg A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions. - Wikipedia:Lamina_propria + @@ -228902,6 +43006,7 @@ The modern definition of neurosecretion has evolved to include the release of an A lamina propria that is part of a respiratory airway. + EMAPA:35877 FMA:265157 MA:0001858 @@ -228932,14 +43037,14 @@ The modern definition of neurosecretion has evolved to include the release of an - true - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + true + A lamina propria that is part of a respiratory airway. - OBOL:automatic + OBOL:automatic @@ -228951,61 +43056,61 @@ The modern definition of neurosecretion has evolved to include the release of an lamina propria mucosa of trachea - OBOL:automatic + OBOL:automatic lamina propria mucosa of windpipe - OBOL:automatic + OBOL:automatic lamina propria mucosae of trachea - OBOL:automatic + OBOL:automatic lamina propria mucosae of windpipe - OBOL:automatic + OBOL:automatic lamina propria of windpipe - OBOL:automatic + OBOL:automatic trachea lamina propria mucosa - OBOL:automatic + OBOL:automatic trachea lamina propria mucosae - OBOL:automatic + OBOL:automatic windpipe lamina propria - OBOL:automatic + OBOL:automatic windpipe lamina propria mucosa - OBOL:automatic + OBOL:automatic windpipe lamina propria mucosae - OBOL:automatic + OBOL:automatic @@ -229037,6 +43142,9 @@ The modern definition of neurosecretion has evolved to include the release of an Organism subdivision that is the part of the body consisting of the cranial and pharyngeal regions.[AAO] Organism subdivision which is the part of the body which consists of the cranial and pharygeal regions.[TAO] Vertebrate evolution has been characterized by a fresh and vast array of cranial structures that collectively form the head.[well established][VHOG] + + + AAO:0010335 AEO:0000106 BILA:0000115 @@ -229046,6 +43154,7 @@ The modern definition of neurosecretion has evolved to include the release of an EFO:0000964 EHDAA2:0003106 EMAPA:31858 + FBbt:00000004 FMA:7154 GAID:61 HAO:0000397 @@ -229054,14 +43163,14 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D006257 MIAA:0000294 NCIT:C12419 - SCTID:302548004 + OpenCyc:Mx4rEOLm4rgPEdmAAAACs6hRjg + OpenCyc:Mx4rvVi6YJwpEbGdrcN5Y29ycA SPD:0000016 TAO:0001114 TGMA:0000002 UMLS:C0018670 VHOG:0001644 WBbt:0005739 - Wikipedia:Head XAO:0003024 ZFA:0001114 galen:Head @@ -229080,42 +43189,47 @@ The modern definition of neurosecretion has evolved to include the release of an The head is the anterior-most division of the body [GO]. + GO:0060322 - Wikipedia:Head Organism subdivision that is the part of the body consisting of the cranial and pharyngeal regions.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010335 - AAO - AAO:BJB + AAO + AAO:BJB Organism subdivision which is the part of the body which consists of the cranial and pharygeal regions.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001114 - TAO - ZFIN:curator + TAO + ZFIN:curator Vertebrate evolution has been characterized by a fresh and vast array of cranial structures that collectively form the head.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001644 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.82 - http://bgee.unil.ch/ UMLS:C0018670 BIRNLEX:1230 + + + + + UMLS:C0018670 ncithesaurus:Head @@ -229136,7 +43250,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -229174,14 +43287,15 @@ The modern definition of neurosecretion has evolved to include the release of an a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP] in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA. + + + FMA:9581 GAID:19 MESH:D012704 NCIT:C13169 - SCTID:362878009 TAO:0005425 UMLS:C0036760 - Wikipedia:Serous_membrane ZFA:0005425 tunica serosa wall of serous sac @@ -229191,8 +43305,8 @@ The modern definition of neurosecretion has evolved to include the release of an serous membrane - http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png - http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png + http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png + http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png @@ -229203,35 +43317,35 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer. - Wikipedia:Serous_membrane - https://github.com/obophenotype/uberon/issues/86 + + A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005425 - TAO - Wikipedia:Serous_membrane + TAO + a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP] - Wikipedia:Serous_membrane + in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA. - FMA + FMA @@ -229256,7 +43370,7 @@ The modern definition of neurosecretion has evolved to include the release of an serosa - Wikipedia:Serous_membrane + @@ -229305,6 +43419,9 @@ The modern definition of neurosecretion has evolved to include the release of an Dense regular connective tissue that connects muscle to bone.[VSAO] Phylogenetically, tendinous tissue first appears in the invertebrate chordate Branchiostoma as myosepta. This two-dimensional array of collagen fibers is highly organized, with fibers running along two primary axes. In hagfish the first linear tendons appear and the myosepta have developed specialized regions with unidirectional fiber orientation - a linear tendon within the flat sheet of myoseptum.[well established][VHOG] in FMA, tendon is an organ component that with parts dense-irregular-connective-tissue of tendon and dense-irregular-connective-tissue of tendon sheath; we follow VSAO in making it a subtype of the former. In VSAO tendons connect muscle to bone; in WP the def states integument (e.g. auricular muscles) - but JB confirms this is not actually tendon but aponeurosis + + + AEO:0000091 BTO:0001356 CALOHA:TS-1021 @@ -229316,11 +43433,10 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000115 MESH:D013710 NCIT:C13045 - SCTID:256667004 + OpenCyc:Mx4rvVjefJwpEbGdrcN5Y29ycA UMLS:C0039508 VHOG:0001286 VSAO:0000073 - Wikipedia:Tendon XAO:0000173 ZFA:0005647 galen:Tendon @@ -229331,13 +43447,13 @@ The modern definition of neurosecretion has evolved to include the release of an tendon - http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg + http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg - VSAO + VSAO @@ -229359,7 +43475,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -229370,41 +43486,41 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO Dense regular connective tissue that connects muscle to bone[VSAO]. - GO_REF:0000034 + + + GO_REF:0000034 VSAO:0000073 - Wikipedia:Tendon - http://dx.plos.org/10.1371/journal.pone.0051070 Dense regular connective tissue that connects muscle to bone.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000073 - VSAO - PSPUB:0000170 + VSAO + PSPUB:0000170 Phylogenetically, tendinous tissue first appears in the invertebrate chordate Branchiostoma as myosepta. This two-dimensional array of collagen fibers is highly organized, with fibers running along two primary axes. In hagfish the first linear tendons appear and the myosepta have developed specialized regions with unidirectional fiber orientation - a linear tendon within the flat sheet of myoseptum.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001286 - VHOG + VHOG + DOI:10.1016/S1095-6433(02)00241-6 Summers AP, Koob TJ, The evolution of tendon - morphology and material properties. Comparative Biochemistry and Physiology-Part A: Molecular and Integrative Physiology (2002) - http://bgee.unil.ch/ in FMA, tendon is an organ component that with parts dense-irregular-connective-tissue of tendon and dense-irregular-connective-tissue of tendon sheath; we follow VSAO in making it a subtype of the former. In VSAO tendons connect muscle to bone; in WP the def states integument (e.g. auricular muscles) - but JB confirms this is not actually tendon but aponeurosis - FMA + FMA @@ -229416,13 +43532,13 @@ The modern definition of neurosecretion has evolved to include the release of an sinew - Wikipedia:Tendon + tendo - Wikipedia:Tendon + @@ -229431,7 +43547,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + + @@ -229458,7 +43575,6 @@ The modern definition of neurosecretion has evolved to include the release of an A biological tissue mass, most commonly a mass of nerve cell bodies. TODO - check vert vs invert. Other species: Any of a number of aggregations of neurons, glial cells and their processes, surrounded by a glial cell and connective tissue sheath (plural: ganglia). // Subdivision of neural tree (organ) which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord); together with a nucleus and its associated nerve, it constitutes a neural tree (organ). Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion. // a cluster of nerve cells and associated glial cells (nuclear location) // Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system. - A ganglion is a cluster of neurons. It is part of a nervous system. It may include glial cells. The neurons are arranged in a specific constellation: neuronal somata are concentrated at the surface, thus forming a cell cortex, and neurites are concentrated in the centre of the ganglion to form the neuropil. A ganglion is a distinct unit but several ganglia may be anterio-posteriorly joined by connectives or transversally by commissures Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system.[AAO] Structures containing a collection of nerve cell bodies. (Source: BioGlossary, www.Biology-Text.com)[TAO] @@ -229466,6 +43582,8 @@ The modern definition of neurosecretion has evolved to include the release of an Cranial sensory placodes are focused areas of the head ectoderm of vertebrates that contribute to the development of the cranial sense organs and their associated ganglia. Placodes have long been considered a key character of vertebrates, and their evolution is proposed to have been essential for the evolution of an active predatory lifestyle by early vertebrates.[well established][VHOG] ganglionic + + AAO:0010426 AEO:0000135 BAMS:G @@ -229493,7 +43611,6 @@ The modern definition of neurosecretion has evolved to include the release of an UMLS:C0017067 VHOG:0000156 WBbt:0005189 - Wikipedia:Ganglion XAO:0000209 ZFA:0000190 uberon @@ -229501,7 +43618,6 @@ The modern definition of neurosecretion has evolved to include the release of an neural ganglion UBERON:0000045 - @@ -229510,8 +43626,8 @@ The modern definition of neurosecretion has evolved to include the release of an - - https://github.com/obophenotype/uberon/issues/2495#issuecomment-1187364719 + + @@ -229522,7 +43638,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -229533,38 +43649,38 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN A biological tissue mass, most commonly a mass of nerve cell bodies. - Wikipedia:Ganglion - https://github.com/obophenotype/uberon/issues/300 + + A ganglion is a cluster of neurons. It is part of a nervous system. It may include glial cells. The neurons are arranged in a specific constellation: neuronal somata are concentrated at the surface, thus forming a cell cortex, and neurites are concentrated in the centre of the ganglion to form the neuropil. A ganglion is a distinct unit but several ganglia may be anterio-posteriorly joined by connectives or transversally by commissures - PMID:21062451 + Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010426 - AAO - AAO:EJS + AAO + AAO:EJS Structures containing a collection of nerve cell bodies. (Source: BioGlossary, www.Biology-Text.com)[TAO] - 2012-08-14 + 2012-08-14 TAO:0000190 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -229576,11 +43692,11 @@ The modern definition of neurosecretion has evolved to include the release of an Cranial sensory placodes are focused areas of the head ectoderm of vertebrates that contribute to the development of the cranial sense organs and their associated ganglia. Placodes have long been considered a key character of vertebrates, and their evolution is proposed to have been essential for the evolution of an active predatory lifestyle by early vertebrates.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000156 - VHOG + VHOG + DOI:10.1016/j.ydbio.2005.02.021 Mazet F, Hutt JA, Milloz J, Millard J, Graham A, Shimeld SM, Molecular evidence from Ciona intestinalis for the evolutionary origin of vertebrate sensory placodes. Developmental Biology (2005) - http://bgee.unil.ch/ @@ -229602,8 +43718,8 @@ The modern definition of neurosecretion has evolved to include the release of an An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity. + TGMA:0000729 - Wikipedia:Eye#Simple_eyes uberon UBERON:0000047 @@ -229614,7 +43730,7 @@ The modern definition of neurosecretion has evolved to include the release of an An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity. - Wikipedia:Eye#Simple_eyes + @@ -229642,7 +43758,7 @@ The modern definition of neurosecretion has evolved to include the release of an A tubular structure that contains, conveys body fluid, such as blood or lymph. - https://orcid.org/0000-0002-6601-2165 + @@ -229650,7 +43766,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -229672,21 +43787,22 @@ The modern definition of neurosecretion has evolved to include the release of an - + A tubular structure that transports secreted or excreted substances. A tube shaped portion of tissue lined with epithelial cells that collects secretions and routes them to their destination[ZFA:0005171]. Most ducts, but not all, are exocrine gland ducts. Some ontologies classify structures such as the oviduct here. + + + AAO:0011123 FBbt:00100314 FMA:30320 NCIT:C12948 - SCTID:91726008 TAO:0005171 UMLS:C0687028 - Wikipedia:Duct_(anatomy) XAO:0004000 ZFA:0005171 galen:Duct @@ -229703,8 +43819,8 @@ The modern definition of neurosecretion has evolved to include the release of an A tubular structure that transports secreted or excreted substances. - http://orcid.org/0000-0002-6601-2165 - http://www.siumed.edu/~dking2/intro/glands.htm#ducts + + @@ -229723,7 +43839,7 @@ The modern definition of neurosecretion has evolved to include the release of an ducts XAO:0004000 - + @@ -229760,6 +43876,9 @@ The modern definition of neurosecretion has evolved to include the release of an A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]. Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG] + + + AAO:0010396 BTO:0000706 CALOHA:TS-1306 @@ -229772,10 +43891,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D007420 MIAA:0000046 NCIT:C12379 - SCTID:181254001 + OpenCyc:Mx4rvVkF5pwpEbGdrcN5Y29ycA UMLS:C0021851 VHOG:0000054 - Wikipedia:Large_intestine_(anatomy) XAO:0000131 galen:LargeIntestine uberon @@ -229787,32 +43905,29 @@ The modern definition of neurosecretion has evolved to include the release of an large intestine - https://ccf-ontology.hubmapconsortium.org/objects/v1.0/SBU_F_Intestine_Large.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb - cjm + cjm A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]. - ISBN:0073040584 - Wikipedia:Large_intestine_(anatomy) + + ISBN:0073040584 Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000054 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.566 - http://bgee.unil.ch/ @@ -229869,7 +43984,7 @@ The modern definition of neurosecretion has evolved to include the release of an in FMA, serosa is a wall - FMA + FMA @@ -229897,9 +44012,8 @@ The modern definition of neurosecretion has evolved to include the release of an Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. - - - + + AAO:0010825 AEO:0000003 BILA:0000003 @@ -229913,18 +44027,15 @@ The modern definition of neurosecretion has evolved to include the release of an HAO:0000003 MA:0003000 MESH:D000825 - SCTID:362889002 TAO:0000037 TGMA:0001823 VHOG:0001759 XAO:0003000 ZFA:0000037 - http://dbpedia.org/ontology/AnatomicalStructure biological structure connected biological structure uberon UBERON:0000061 - anatomical structure @@ -229985,11 +44096,11 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure that performs a specific function or group of functions [WP]. - - - Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. CARO v1 does not include a generic 'organ' class, only simple and compound organ. CARO v2 may include organ, see https://github.com/obophenotype/caro/issues/4 + + + BIRNLEX:4 CARO:0020004 EFO:0000634 @@ -229998,16 +44109,15 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:67498 MA:0003001 NCIT:C13018 - SCTID:272625005 + OpenCyc:Mx4rv5XMb5wpEbGdrcN5Y29ycA + OpenCyc:Mx4rwP3iWpwpEbGdrcN5Y29ycA UMLS:C0178784 WBbt:0003760 - Wikipedia:Organ_(anatomy) uberon anatomical unit body organ element UBERON:0000062 - organ @@ -230015,19 +44125,19 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:28192867 + Anatomical structure that performs a specific function or group of functions [WP]. - Wikipedia:Organ_(anatomy) + - Wikipedia + Wikipedia @@ -230045,7 +44155,7 @@ The modern definition of neurosecretion has evolved to include the release of an element - http://orcid.org/0000-0002-6601-2165 + @@ -230071,7 +44181,7 @@ The modern definition of neurosecretion has evolved to include the release of an A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity. - http://orcid.org/0000-0002-6601-2165 + @@ -230120,20 +44230,16 @@ The modern definition of neurosecretion has evolved to include the release of an A multicellular structure that is a part of an organ. currently defined in a very broad sense, may be replaced by more specific classes in the future - - - + + AAO:0011124 BIRNLEX:16 EFO:0000635 FMA:82472 - SCTID:113343008 - SCTID:91717005 cardinal organ part uberon regional part of organ UBERON:0000064 - @@ -230143,7 +44249,7 @@ The modern definition of neurosecretion has evolved to include the release of an A multicellular structure that is a part of an organ. - http://orcid.org/0000-0002-6601-2165 + @@ -230185,12 +44291,13 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts. + EHDAA2:0001606 EHDAA:1568 EHDAA:2219 EMAPA:16737 FMA:265130 - SCTID:361110005 + OpenCyc:Mx4rvvM--pwpEbGdrcN5Y29ycA VHOG:0000393 uberon UBERON:0000065 @@ -230212,7 +44319,7 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts. - https://orcid.org/0000-0002-6601-2165 + @@ -230259,7 +44366,7 @@ The modern definition of neurosecretion has evolved to include the release of an The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage. - https://orcid.org/0000-0002-6601-2165 + @@ -230268,6 +44375,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + @@ -230294,6 +44407,7 @@ The modern definition of neurosecretion has evolved to include the release of an A life cycle stage that starts with fertilization and ends with the fully formed embryo. + BilaDO:0000002 EV:0300001 FBdv:00005289 @@ -230302,7 +44416,6 @@ The modern definition of neurosecretion has evolved to include the release of an MmusDv:0000002 OGES:000000 OGES:000022 - SCTID:296280003 WBls:0000003 WBls:0000092 WBls:0000102 @@ -230317,7 +44430,7 @@ The modern definition of neurosecretion has evolved to include the release of an A life cycle stage that starts with fertilization and ends with the fully formed embryo. - http://orcid.org/0000-0002-6601-2165 + @@ -230326,6 +44439,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + @@ -230364,13 +44483,13 @@ The modern definition of neurosecretion has evolved to include the release of an Uberon includes clade-specific subclasses, e.g. nematod larva It is a misunderstanding that the larval form always reflects the group's evolutionary history. It could be the case, but often the larval stage has evolved secondarily, as in insects. In these cases the larval form might differ more from the group's common origin than the adult form + BTO:0000915 BTO:0000954 EFO:0001303 FBdv:00005336 MIAA:0000400 OGES:000008 - Wikipedia:Larva ZFS:0000048 larva stage ammocoete @@ -230415,110 +44534,110 @@ The modern definition of neurosecretion has evolved to include the release of an A distinct juvenile stage many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle. - Wikipedia:Larva + It is a misunderstanding that the larval form always reflects the group's evolutionary history. It could be the case, but often the larval stage has evolved secondarily, as in insects. In these cases the larval form might differ more from the group's common origin than the adult form - WP + WP ammocoete - Wikipedia:Larva + ammocoete stage - Wikipedia:Larva + bipinnaria - Wikipedia:Larva + bipinnaria stage - Wikipedia:Larva + caterpillar - Wikipedia:Larva + caterpillar stage - Wikipedia:Larva + glochidium - Wikipedia:Larva + glochidium stage - Wikipedia:Larva + grub - Wikipedia:Larva + grub stage - Wikipedia:Larva + leptocephalus - Wikipedia:Larva + leptocephalus stage - Wikipedia:Larva + maggot - Wikipedia:Larva + maggot stage - Wikipedia:Larva + @@ -230532,56 +44651,56 @@ The modern definition of neurosecretion has evolved to include the release of an naiad, nymph - Wikipedia:Larva + naiad, nymph stage - Wikipedia:Larva + nauplius - Wikipedia:Larva + nauplius stage - Wikipedia:Larva + nymph - Wikipedia:Larva + nymph stage - Wikipedia:Larva + planula - Wikipedia:Larva + planula stage - Wikipedia:Larva + @@ -230595,56 +44714,56 @@ The modern definition of neurosecretion has evolved to include the release of an trochophore - Wikipedia:Larva + trochophore stage - Wikipedia:Larva + veliger - Wikipedia:Larva + veliger stage - Wikipedia:Larva + wriggler - Wikipedia:Larva + wriggler stage - Wikipedia:Larva + zoea - Wikipedia:Larva + zoea stage - Wikipedia:Larva + @@ -230667,16 +44786,12 @@ The modern definition of neurosecretion has evolved to include the release of an End of the life of an organism. - - - ncit:Death is an outcome XAO:0000437 XtroDO:0000085 uberon death UBERON:0000071 - death stage @@ -230732,13 +44847,13 @@ The modern definition of neurosecretion has evolved to include the release of an An section of a respiratory tract. - http://orcid.org/0000-0002-6601-2165 + MA:0000434 has subclasses upper and lower, so it corresponds to a segment of the tract, rather than the tract as a whole - MA + MA @@ -230764,6 +44879,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -230779,9 +44895,10 @@ The modern definition of neurosecretion has evolved to include the release of an Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS. 2009-06-18T09:00:04Z + + BIRNLEX:1157 NCIT:C13040 - SCTID:25087005 UMLS:C1518256 part of nervous system uberon @@ -230835,9 +44952,10 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism. UBERON:0010322 + + FMA:85544 NCIT:C34076 - SCTID:118966000 UMLS:C1519343 galen:ComplexSkeletalStructure skeletal system subdivision @@ -230851,14 +44969,14 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism. - UBERONREF:0000003 - https://orcid.org/0000-0002-6601-2165 + + UBERONREF:0000003 @@ -230879,6 +44997,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -230896,7 +45015,8 @@ The modern definition of neurosecretion has evolved to include the release of an merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube) (or external ectoderm) forms the following structures: Skin Epithelium of the mouth and nasal cavity saliavary glands, and glands of mouth and nasal cavity Enamel - as a side note dentin and dental pulp are formed from ectomesenchyme which is derived from ectoderm Epithelium of pineal and pituitary glands Lens and cornea of the eye Apical ectodermal ridge inducing development of the limb buds of the embryo. Sensory receptors in epidermis - BTO:0006242 + + EHDAA2:0001968 EHDAA:1494 EHDAA:350 @@ -230908,20 +45028,19 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:87656 NCIT:C34309 UMLS:C1515087 - Wikipedia:External_ectoderm surface (external) ectoderm surface ectoderm uberon UBERON:0000076 external ectoderm - http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png + http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png - EHDAA2 + EHDAA2 @@ -230932,21 +45051,15 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm. - MGI:anna + MGI:anna MP:0012532 - - - - BTO:0006242 - https://orcid.org/0000-0003-4423-4370 - @@ -231005,7 +45118,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical structure that develops from the endoderm and the mesoderm. - https://orcid.org/0000-0002-6601-2165 + @@ -231063,7 +45176,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical structure that develops from the ectoderm, mesoderm and endoderm. - https://orcid.org/0000-0002-6601-2165 + @@ -231072,6 +45185,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -231104,21 +45218,22 @@ The modern definition of neurosecretion has evolved to include the release of an A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum. EHDAA2 has embryo starting later + + + BTO:0001508 EHDAA2:0000005 FMA:292334 GAID:1295 MESH:D009028 NCIT:C34212 - SCTID:361474003 UMLS:C0026573 - Wikipedia:Morula uberon morula (2-16 cells) UBERON:0000085 morula - http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png + http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png @@ -231129,7 +45244,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -231141,7 +45256,7 @@ The modern definition of neurosecretion has evolved to include the release of an EHDAA2 has embryo starting later - EHDAA2 + EHDAA2 @@ -231161,7 +45276,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + + @@ -231190,6 +45306,8 @@ The modern definition of neurosecretion has evolved to include the release of an Outside the plasma membrane, three envelopes surround the ovum. The first, the primary egg envelope, lies between the plasma membrane and the surrounding cells of the ovary. The most consistent component of this primary layer is the vitelline membrane, a transparent jacket of fibrous protein. In mammals, the homologous structure is called the zona pellucida.[well established][VHOG] zona pellucida - vitelline membrane + + BTO:0003135 EHDAA2:0002220 EHDAA:31 @@ -231203,7 +45321,6 @@ The modern definition of neurosecretion has evolved to include the release of an TAO:0001111 UMLS:C0043519 VHOG:0000720 - Wikipedia:Zona_pellucida ZFA:0001111 uberon oolemma @@ -231218,23 +45335,23 @@ The modern definition of neurosecretion has evolved to include the release of an zona pellucida - http://upload.wikimedia.org/wikipedia/commons/8/81/Gray3.png + http://upload.wikimedia.org/wikipedia/commons/8/81/Gray3.png A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes. - Wikipedia:Zona_pellucida + Outside the plasma membrane, three envelopes surround the ovum. The first, the primary egg envelope, lies between the plasma membrane and the surrounding cells of the ovary. The most consistent component of this primary layer is the vitelline membrane, a transparent jacket of fibrous protein. In mammals, the homologous structure is called the zona pellucida.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000720 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.159 - http://bgee.unil.ch/ @@ -231284,6 +45401,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -231313,16 +45431,17 @@ The modern definition of neurosecretion has evolved to include the release of an A group of cells found in the mammalian blastocyst that give rise to the embryo. [Biology_Online][VHOG] A small sphere of cells known as the inner cell mass lies within the trophoblast (of all eutherian mammals).[well established][VHOG] This structure forms in the earliest steps of development, before implantation into the endometrium of the uterus has occurred.The ICM lies within the blastocyst cavity and is entirely surrounded by the single layer of cells called trophoblast. [Wikipedia:Inner_cell_mass] + + + EFO:0000547 EHDAA2:0000830 EHDAA:40 EMAPA:16041 FMA:86557 NCIT:C13740 - SCTID:361456007 UMLS:C1283994 VHOG:0000742 - Wikipedia:Inner_cell_mass uberon ICM early embryoblast @@ -231334,7 +45453,7 @@ The modern definition of neurosecretion has evolved to include the release of an inner cell mass - https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg + https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg @@ -231345,7 +45464,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -231356,7 +45475,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -231367,7 +45486,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia @@ -231378,33 +45497,33 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia A mass of cells that develop into the body of the embryo and some extraembryonic tissues. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MGI:pvb A group of cells found in the mammalian blastocyst that give rise to the embryo. [Biology_Online][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000742 - VHOG - http://bgee.unil.ch/ + VHOG + A small sphere of cells known as the inner cell mass lies within the trophoblast (of all eutherian mammals).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000742 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.144 - http://bgee.unil.ch/ @@ -231428,7 +45547,7 @@ The modern definition of neurosecretion has evolved to include the release of an embryoblastus; massa cellularis interna; pluriblastus senior - Wikipedia:Inner_cell_mass + @@ -231437,6 +45556,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -231457,9 +45577,13 @@ The modern definition of neurosecretion has evolved to include the release of an The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta. + the mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta[MP] trophoblastic The postimplantation derivatives of the trophectoderm, which make up most of the fetal part of the placenta + + + BTO:0001079 CALOHA:TS-1070 EV:0100120 @@ -231467,9 +45591,7 @@ The modern definition of neurosecretion has evolved to include the release of an GAID:1152 MESH:D014327 NCIT:C93292 - SCTID:362839005 UMLS:C0041178 - Wikipedia:Trophoblast trophoblast layer uberon massa cellularis externa @@ -231477,10 +45599,11 @@ The modern definition of neurosecretion has evolved to include the release of an trophoderm UBERON:0000088 + Aggregate of cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. [Wikipedia:Trophoblast] trophoblast - https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg + https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg @@ -231491,14 +45614,14 @@ The modern definition of neurosecretion has evolved to include the release of an + MP-def - PMID:19829370 The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0005031 @@ -231509,13 +45632,13 @@ The modern definition of neurosecretion has evolved to include the release of an MP:0005031 trophoblast layer MP - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 The postimplantation derivatives of the trophectoderm, which make up most of the fetal part of the placenta - PMID:19829370 + @@ -231533,14 +45656,14 @@ The modern definition of neurosecretion has evolved to include the release of an massa cellularis externa - Wikipedia:Trophoblast + trophoblastus - Wikipedia:Trophoblast + @@ -231555,6 +45678,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -231567,10 +45691,11 @@ The modern definition of neurosecretion has evolved to include the release of an embryonic shield germinal disc germinal disk + + FMA:293863 NCIT:C34112 UMLS:C1283997 - Wikipedia:Bilaminar_disc bilaminary embryonic disc bilaminary germ disc uberon @@ -231579,7 +45704,7 @@ The modern definition of neurosecretion has evolved to include the release of an bilaminar disc - http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png + http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png @@ -231590,7 +45715,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia @@ -231638,7 +45763,7 @@ The modern definition of neurosecretion has evolved to include the release of an bilaminar disk - Wikipedia:Bilaminar_disc + @@ -231647,6 +45772,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + @@ -231686,7 +45817,7 @@ The modern definition of neurosecretion has evolved to include the release of an Stage succeeding embryo, including mature structure. - https://orcid.org/0000-0002-6601-2165 + @@ -231694,7 +45825,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -231754,8 +45884,8 @@ The modern definition of neurosecretion has evolved to include the release of an ZFA treats this as a subtype of NC. 2009-07-30T07:57:38Z + TAO:0002173 - Wikipedia:Cardiac_neural_crest XAO:0004190 ZFA:0001648 uberon @@ -231774,19 +45904,19 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia]. - Wikipedia:Cardiac_neural_crest + A subpopulation of the cephalic neural crest that emerges from the otic level to the anterior limit of somite 4. It migrates to the heart and is essential for the septation of the outflow track[DOI:10.1242/dev.091751]. - DOI:10.1242/dev.091751 + @@ -231798,73 +45928,13 @@ The modern definition of neurosecretion has evolved to include the release of an cardiac neural crest complex - Wikipedia:Cardiac_neural_crest + complexus cristae neuralis cardiacus - Wikipedia:Cardiac_neural_crest - - - - - - - - - - - - - - - - - - - - - - A lung lobe is one of the rounded projections that compose the lung[GO]. - EMAPA:36281 - FMA:7311 - MA:0003098 - NCIT:C34021 - SCTID:245524004 - UMLS:C0225752 - galen:LobeOfLung - lung lobe - pulminory lobe - pulmonary lobe - uberon - UBERON:0000101 - - lobe of lung - - - - - - FMA - - - - - A lung lobe is one of the rounded projections that compose the lung[GO]. - GOC:GO - - - - - UMLS:C0225752 - ncithesaurus:Lung_Lobe - - - - - pulmonary lobe - FMA:7311 + @@ -231883,6 +45953,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -231912,7 +45983,7 @@ The modern definition of neurosecretion has evolved to include the release of an lung vascular network - OBOL:automatic + OBOL:automatic @@ -231924,13 +45995,13 @@ The modern definition of neurosecretion has evolved to include the release of an vascular network of lung - OBOL:automatic + OBOL:automatic vasculature of lung - OBOL:automatic + OBOL:automatic @@ -231951,10 +46022,7 @@ The modern definition of neurosecretion has evolved to include the release of an - An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism. - - - + An entire span of an organism's life, commencing with the zygote stage and ending in the death of the organism. FBdv:00000000 HsapDv:0000001 MmusDv:0000001 @@ -231966,7 +46034,6 @@ The modern definition of neurosecretion has evolved to include the release of an lifespan uberon UBERON:0000104 - life cycle https://github.com/obophenotype/uberon/issues/532 @@ -231974,8 +46041,8 @@ The modern definition of neurosecretion has evolved to include the release of an - An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism. - https://orcid.org/0000-0002-6601-2165 + An entire span of an organism's life, commencing with the zygote stage and ending in the death of the organism. + @@ -231992,9 +46059,6 @@ The modern definition of neurosecretion has evolved to include the release of an A spatiotemporal region encompassing some part of the life cycle of an organism. this class represents a proper part of the life cycle of an organism. The class 'life cycle' should not be placed here - - - the WBls class 'all stages' belongs here as it is the superclass of other WBls stages we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage BILS:0000105 @@ -232015,7 +46079,6 @@ The modern definition of neurosecretion has evolved to include the release of an stage uberon UBERON:0000105 - life cycle stage @@ -232024,7 +46087,7 @@ The modern definition of neurosecretion has evolved to include the release of an A spatiotemporal region encompassing some part of the life cycle of an organism. - https://orcid.org/0000-0002-6601-2165 + @@ -232047,16 +46110,15 @@ The modern definition of neurosecretion has evolved to include the release of an A stage at which the organism is a single cell produced by means of sexual reproduction. As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG] + BILS:0000106 BilaDO:0000005 EFO:0001322 EHDAA:27 FBdv:00005288 - IDOMAL:0000302 NCIT:C12601 PdumDv:0000100 VHOG:0000745 - Wikipedia:Zygote XAO:1000001 ZFS:0000001 1-cell stage @@ -232076,23 +46138,17 @@ The modern definition of neurosecretion has evolved to include the release of an A stage at which the organism is a single cell produced by means of sexual reproduction. - Wikipedia:Zygote + As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000745 - VHOG + VHOG + ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.107 - http://bgee.unil.ch/ - - - - - IDOMAL:0000302 - https://orcid.org/0000-0003-4423-4370 @@ -232116,7 +46172,7 @@ The modern definition of neurosecretion has evolved to include the release of an zygotum - Wikipedia:Zygote + @@ -232137,6 +46193,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + @@ -232156,6 +46218,7 @@ The modern definition of neurosecretion has evolved to include the release of an The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula. + BILS:0000107 BilaDO:0000006 EFO:0001290 @@ -232165,7 +46228,6 @@ The modern definition of neurosecretion has evolved to include the release of an OGES:000015 OGES:000020 PdumDv:0000200 - Wikipedia:Cleavage_(embryo) XAO:1000004 ZFS:0000046 uberon @@ -232177,8 +46239,8 @@ The modern definition of neurosecretion has evolved to include the release of an The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula. + GO:0040016 - Wikipedia:Cleavage_(embryo) @@ -232201,6 +46263,7 @@ The modern definition of neurosecretion has evolved to include the release of an An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. consider adding a preceding stage 'morula stage' as part of cleavage + BILS:0000108 BilaDO:0000007 EFO:0001282 @@ -232209,21 +46272,21 @@ The modern definition of neurosecretion has evolved to include the release of an OGES:000003 OGES:000016 OGES:000021 + OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg WBls:0000005 - Wikipedia:Blastula XAO:1000003 ZFS:0000045 uberon UBERON:0000108 blastula stage - http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png + http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. - Wikipedia:Blastula + @@ -232232,6 +46295,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + @@ -232300,37 +46369,37 @@ The modern definition of neurosecretion has evolved to include the release of an blastocystis trilaminaris stage - https://orcid.org/0000-0002-6601-2165 + trilaminar blastocyst stage - https://orcid.org/0000-0002-6601-2165 + trilaminar blastoderm stage - https://orcid.org/0000-0002-6601-2165 + trilaminar disk stage - https://orcid.org/0000-0002-6601-2165 + trilaminar germ stage - https://orcid.org/0000-0002-6601-2165 + trilaminar stage - https://orcid.org/0000-0002-6601-2165 + @@ -232339,6 +46408,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + @@ -232364,8 +46439,6 @@ The modern definition of neurosecretion has evolved to include the release of an Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. - - In zebrafish, the times of neurulation and segmentation overlap so extensively there is no distinct neurula period of development, such as occurs largely before segmentation in amphibian embryos. BILS:0000110 BilaDO:0000009 HsapDv:0000012 @@ -232374,7 +46447,6 @@ The modern definition of neurosecretion has evolved to include the release of an uberon UBERON:0000110 neurula stage - https://github.com/obophenotype/developmental-stage-ontologies/issues/84 https://github.com/obophenotype/uberon/issues/343 @@ -232390,12 +46462,24 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + @@ -232409,25 +46493,24 @@ The modern definition of neurosecretion has evolved to include the release of an A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism. + BILS:0000111 BilaDO:0000010 HsapDv:0000015 MmusDv:0000018 OGES:000005 OGES:000032 - Wikipedia:Organogenesis uberon segmentation stage UBERON:0000111 organogenesis stage - https://github.com/obophenotype/developmental-stage-ontologies/issues/84 https://github.com/obophenotype/uberon/issues/533 A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism. - Wikipedia:Organogenesis + @@ -232476,10 +46559,10 @@ The modern definition of neurosecretion has evolved to include the release of an The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin. it functions in the mechanical behavior of the lung, and forms a barrier to regulate the flow of plasma constituents from the capillaries to the airway and alveolar spaces + EMAPA:35521 FMA:27533 MA:0001782 - SCTID:201609008 connective tissue of lung pulmonary interstitium uberon @@ -232496,16 +46579,16 @@ The modern definition of neurosecretion has evolved to include the release of an The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin. - ISBN:0-683-40008-8 - MGI:anna + + ISBN:0-683-40008-8 + MGI:anna MP:0002276 - PMID:14635660 connective tissue of lung - OBOL:automatic + OBOL:automatic @@ -232585,19 +46668,19 @@ The modern definition of neurosecretion has evolved to include the release of an epithelial tissue of lung - OBOL:automatic + OBOL:automatic epithelium of lung - OBOL:automatic + OBOL:automatic lung epithelial tissue - OBOL:automatic + OBOL:automatic @@ -232622,7 +46705,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -232654,8 +46736,8 @@ The modern definition of neurosecretion has evolved to include the release of an A tube in the respiratory system. Examples: bronchus, bronchiole, trachea. + GO:0030323 - http://orcid.org/0000-0002-6601-2165 @@ -232667,7 +46749,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37946 - MA:th + MA:th @@ -232721,14 +46803,16 @@ The modern definition of neurosecretion has evolved to include the release of an Structure derived from foregut that becomes a lung[GO]. clarify successors - include bronchi? + + + + BTO:0001643 EHDAA2:0004089 NCIT:C34260 NCIT:C34282 - SCTID:361427007 UMLS:C1514420 UMLS:C1514897 - Wikipedia:Respiratory_bud uberon gemma pulmonalis gemma respiratoria @@ -232738,7 +46822,7 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0000118 lung bud - http://upload.wikimedia.org/wikipedia/commons/7/71/Gray948.png + http://upload.wikimedia.org/wikipedia/commons/7/71/Gray948.png @@ -232755,14 +46839,14 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Structure derived from foregut that becomes a lung[GO]. + GO:0060431 - Wikipedia:Respiratory_bud @@ -232780,21 +46864,21 @@ The modern definition of neurosecretion has evolved to include the release of an gemma pulmonalis - Wikipedia:Lung_buds + gemma respiratoria - Wikipedia:Lung_buds + lung bud - + @@ -232806,7 +46890,7 @@ The modern definition of neurosecretion has evolved to include the release of an respiratory diverticulum - Wikipedia:Lung_buds + @@ -232814,6 +46898,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -232844,7 +46929,7 @@ The modern definition of neurosecretion has evolved to include the release of an A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses. CARO:0001001 - FBC:DOS + FBC:DOS FBbt:00005099 @@ -232882,11 +46967,11 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure consisting of a discrete aggregate of neuronal soma[GO][GO_REF:0000021]. Proposed CUMBO def from MM: A subcortical part of the nervous system consisting of a relatively compact group of cells that is distinguishable histologically that share a commonality of cytoarchitecture, chemoarchitecturel and connectivity. (comments: I put in 'subcortical' because I don't think we consider either the cerebellar cortex or cerebral cortex to be nuclei. Some people distinguish between a nucleus and a laminar structure (see Wikipedia definition). However, there are structures identified as nuclei that are laminar, e.g., lateral geniculate nucleus, although they are not laminated in all species. Also, I put in 'relatively compact' and 'distiguishable by histology' because we have groups of cells, e.g., cholinergic cell groups, doparminergic cell groups that are related on the 3 criteria but which we don't tend to consider nuclei because they don't occupy an easily defined territory. But all is open to debate. nucleus + AEO:0000136 FMA:83686 NCIT:C13197 NLX:28443 - Wikipedia:Nucleus_(neuroanatomy) nervous system nucleus neuraxis nucleus neuronal nucleus @@ -232980,18 +47065,18 @@ The modern definition of neurosecretion has evolved to include the release of an Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves. + + EMAPA:37066 FMA:54501 NLX:28532 - SCTID:280160003 - Wikipedia:Cranial_nerve_nucleus cranial neural nucleus nucleus of cranial nerve uberon nucleus nervi cranialis UBERON:0000126 cranial nerve nucleus - http://upload.wikimedia.org/wikipedia/commons/3/30/Gray696.png + http://upload.wikimedia.org/wikipedia/commons/3/30/Gray696.png @@ -233003,7 +47088,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37066 - MA:th + MA:th @@ -233015,7 +47100,7 @@ The modern definition of neurosecretion has evolved to include the release of an nucleus nervi cranialis - Wikipedia:Cranial_nerve_nucleus + @@ -233046,7 +47131,7 @@ The modern definition of neurosecretion has evolved to include the release of an - lexical + lexical @@ -233069,7 +47154,7 @@ The modern definition of neurosecretion has evolved to include the release of an - lexical + lexical @@ -233154,6 +47239,9 @@ The modern definition of neurosecretion has evolved to include the release of an The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus. requires alignment with EHDAA2 and complete developmental relationships + + + BTO:0001978 CALOHA:TS-2160 EMAPA:18256 @@ -233161,9 +47249,7 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000330 MESH:D001003 NCIT:C12375 - SCTID:245438008 UMLS:C0227411 - Wikipedia:Anal_canal galen:AnalCanal anal canal anal canal viewed anatomically @@ -233181,7 +47267,7 @@ The modern definition of neurosecretion has evolved to include the release of an anal canal - https://upload.wikimedia.org/wikipedia/commons/0/01/Gray1078.png + https://upload.wikimedia.org/wikipedia/commons/0/01/Gray1078.png @@ -233198,7 +47284,7 @@ The modern definition of neurosecretion has evolved to include the release of an The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus. - Wikipedia:Anal_canal + @@ -233210,10 +47296,15 @@ The modern definition of neurosecretion has evolved to include the release of an canalis analis - BTO:0001978 - Wikipedia:Anal_canal + + + + + canalis analis + BTO:0001978 + @@ -233245,6 +47336,9 @@ The modern definition of neurosecretion has evolved to include the release of an The tract of the alimentary canal. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] intestinal In zebrafish, No stomach, small intestine, or large intestine can be distinguished. However, differences can be found in the morphology of the mucosa columnar epithelial cells and the number of goblet cells, suggesting functional differentiation. The intestine has numerous folds that become progressively shorter in a rostral-to-caudal direction. Proportionally, these folds are significantly larger than the finger-like intestinal villi of mammals and other amniotes (Wallace et al. 2005). Columnar-shaped absorptive enterocytes are the most numerous in the zebrafish intestinal epithelium. Goblet cells are the second most populous epithelial cell type. + + + AAO:0000246 ANISEED:1235303 BSA:0000093 @@ -233260,12 +47354,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D007422 MIAA:0000043 NCIT:C12736 - SCTID:256876008 TAO:0001338 UMLS:C0021853 VHOG:0000056 WBbt:0005772 - Wikipedia:Intestine XAO:0000129 ZFA:0001338 galen:Intestine @@ -233283,32 +47375,32 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine. + GOC:GO - Wikipedia:Intestine Portion of the alimentary canal bounded anteriorly by the pyloric sphincter and posteriorly by the cloacal sphincter.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000246 - AAO - AAO:EJS + AAO + AAO:EJS The tract of the alimentary canal. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000056 - VHOG - http://bgee.unil.ch/ + VHOG + @@ -233327,8 +47419,8 @@ The modern definition of neurosecretion has evolved to include the release of an in FMA, this is an anatomical conduit *space*, rather than anatomical conduit anatomical ostium ostium + FMA:3724 - SCTID:91837002 anatomical orifice hilum uberon @@ -233345,7 +47437,7 @@ The modern definition of neurosecretion has evolved to include the release of an in FMA, this is an anatomical conduit *space*, rather than anatomical conduit - FMA + FMA @@ -233365,6 +47457,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -233393,15 +47486,16 @@ The modern definition of neurosecretion has evolved to include the release of an cloacal Human beings only have an embryonic cloaca, which is split up into separate tracts during the development of the urinary and reproductive organs hindgut endoderm and proctodeal ectoderm. + + + + AAO:0000095 GAID:1206 MESH:D002988 NCIT:C34127 - SCTID:362857006 - SCTID:370631000 UMLS:C0008987 VHOG:0001186 - Wikipedia:Cloaca XAO:0000244 ZFA:0005781 uberon @@ -233419,7 +47513,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -233430,14 +47524,14 @@ The modern definition of neurosecretion has evolved to include the release of an - AAO + AAO Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures. - ISBN:0073040584 - Wikipedia:Cloaca + + ISBN:0073040584 @@ -233449,36 +47543,36 @@ The modern definition of neurosecretion has evolved to include the release of an A common passage for fecal, urinary, and reproductive discharge in most lower vertebrates as well as the terminal end of the hindgut before division into rectum, bladder, and genital primordia in mammalian embryos. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001186 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/cloaca + VHOG + + Anatomical structure which is the common receptacle for the alimentary canal, Wolffian ducts, oviducts, and the bladder.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000095 - AAO - AAO:BJB + AAO + AAO:BJB A cloaca is apparently a primitive vertebrate feature because it occurs in most primitive gnathostomes and persists in the embryos of almost all vertebrates.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001186 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.572 - http://bgee.unil.ch/ hindgut endoderm and proctodeal ectoderm. - WP + WP @@ -233531,10 +47625,10 @@ The modern definition of neurosecretion has evolved to include the release of an Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]. this class represents the embryonic form of the cloaca, as found in both mammals and non-mammals. + EHDAA2:0000256 EHDAA:4895 EMAPA:27573 - Wikipedia:Cloaca_(embryology) uberon cloaca UBERON:0000163 @@ -233550,7 +47644,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -233561,14 +47655,14 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]. + MP:0010115 - Wikipedia:Cloaca_(embryology) @@ -233594,12 +47688,24 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + @@ -233618,6 +47724,9 @@ The modern definition of neurosecretion has evolved to include the release of an oral some AOs place this as developing from the stomodeum but we weaken this to developmental contribution, as the mouth includes non-ectodermal derivatives in FMA, the tongue, palate etc are part of the mouth which is itself a subdivision of the face. ZFA includes a separate class 'oral region' which is part of the mouth, but excludes tongue and lips + + + AAO:0010355 BTO:0001090 BTO:0004698 @@ -233634,19 +47743,17 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000038 MESH:D009055 MIAA:0000038 - SCTID:21082005 + OpenCyc:Mx4rvVidh5wpEbGdrcN5Y29ycA TADS:0000040 TAO:0000547 TAO:0000590 TGMA:0000131 VHOG:0000280 VHOG:0000812 - Wikipedia:Mouth XAO:0003029 ZFA:0000547 ZFA:0000590 galen:Mouth - http://purl.obolibrary.org/obo/uberon/images/lamprey_sucker_rosava_3238889218.jpg regio oralis adult mouth uberon @@ -233670,7 +47777,7 @@ The modern definition of neurosecretion has evolved to include the release of an mouth https://github.com/obophenotype/uberon/issues/661 - http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg + http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg @@ -233678,52 +47785,68 @@ The modern definition of neurosecretion has evolved to include the release of an the mouth contains structures such as jaw skeleton that may not strictly be considered tract parts + + + + + + + + + + exceptions in some taxa + The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks). - Wikipedia:Mouth - https://github.com/obophenotype/uberon/wiki/The-digestive-tract + + Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010355 - AAO - AAO:BJB + AAO + AAO:BJB Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000812 - VHOG + VHOG + DOI:10.1038/nature07309 Hejnol A, Martindale MQ, Acoel development indicates the independent evolution of the bilaterian mouth and anus. Nature (2008) - http://bgee.unil.ch/ in FMA, the tongue, palate etc are part of the mouth which is itself a subdivision of the face. ZFA includes a separate class 'oral region' which is part of the mouth, but excludes tongue and lips - FMA + FMA regio oralis BTO:0004698 + + + + + regio oralis FMA:49184 - FMA:TA + FMA:TA cavital oralis - Wikipedia:Mouth + @@ -233772,7 +47895,7 @@ The modern definition of neurosecretion has evolved to include the release of an trophic apparatus - http://orcid.org/0000-0002-6601-2165 + @@ -233793,6 +47916,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -233816,23 +47940,23 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The orifice that connects the mouth to the exterior of the body. - https://github.com/obophenotype/uberon/wiki/The-digestive-tract + (...) mouth development is very similar in protostomes and 'basal' deuterostomes, whereas the chordate mouth seems to develop at a new position. Recent data for echinoderms and hemichordates further suggest that this change in mouth position may result from change in the influence of a conserved ectodermal patterning system on mouth development. It has been suggested that the mouths of vertebrates and urochordates may constitute a 'new' mouth.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000280 - VHOG + VHOG + DOI:10.1016/j.semcdb.2007.06.002 Christiaen L, Jaszczyszyn Y, Kerfant M, Kanob S, Thermes V, Joly JS, Evolutionary modification of mouth position in deuterostomes. Seminars in Cell and Developmental Biology (2007) - http://bgee.unil.ch/ @@ -233869,6 +47993,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -233892,6 +48017,8 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical cavity bounded anteriorly by the mouth and posteriorly by the derivatives of the branchial arches.[AAO] The cavity of the mouth, bounded by the jaw bones and associated structures (muscles and mucosa). [TFD][VHOG] Echinoderms, hemichordates, and chordates are called deuterostomes because the mouth arises not from the blastopore but from a second invagination at the anterior end of the larva that pushes in to connect with the archenteron.[well established][VHOG] + + AAO:0000053 AAO:0000960 BSA:0000107 @@ -233905,7 +48032,6 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:20292 HAO:0000669 NCIT:C12421 - SCTID:181220002 TAO:0001027 TGMA:0000102 UMLS:C0226896 @@ -233927,38 +48053,38 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present). - ISBN:0073040584 - https://github.com/obophenotype/uberon/wiki/The-digestive-tract - https://orcid.org/0000-0002-6601-2165 + + + ISBN:0073040584 Anatomical cavity bounded anteriorly by the mouth and posteriorly by the derivatives of the branchial arches.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000960 - AAO - AAO:EJS + AAO + AAO:EJS The cavity of the mouth, bounded by the jaw bones and associated structures (muscles and mucosa). [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000188 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/oral+cavity + VHOG + + Echinoderms, hemichordates, and chordates are called deuterostomes because the mouth arises not from the blastopore but from a second invagination at the anterior end of the larva that pushes in to connect with the archenteron.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000188 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.32 - http://bgee.unil.ch/ @@ -233971,7 +48097,7 @@ The modern definition of neurosecretion has evolved to include the release of an buccal cavity FMA:20292 - ISBN:0073040584 + ISBN:0073040584 @@ -234016,13 +48142,13 @@ The modern definition of neurosecretion has evolved to include the release of an 4 - cjm + cjm A section dividing a colon along a proximal-distal axis. - http://orcid.org/0000-0002-6601-2165 + @@ -234051,6 +48177,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -234091,13 +48218,16 @@ The modern definition of neurosecretion has evolved to include the release of an The pair of anatomical structures comprised of a left lung and right lung. + FMA:68877 + OpenCyc:Mx4rvVjKy5wpEbGdrcN5Y29ycA lungs lungs pair pulmones set of lungs uberon UBERON:0000170 + pair of lungs @@ -234116,14 +48246,14 @@ The modern definition of neurosecretion has evolved to include the release of an The pair of anatomical structures comprised of a left lung and right lung. - http://orcid.org/0000-0002-6601-2165 + pulmones FMA:68877 - FMA:TA + FMA:TA @@ -234157,8 +48287,8 @@ The modern definition of neurosecretion has evolved to include the release of an Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. + EMAPA:17607 - SCTID:272626006 SPD:0000428 TGMA:0001247 apparatus respiratorius organ @@ -234184,25 +48314,25 @@ The modern definition of neurosecretion has evolved to include the release of an apparatus respiratorius organ - OBOL:automatic + OBOL:automatic organ of apparatus respiratorius - OBOL:automatic + OBOL:automatic organ of respiratory system - OBOL:automatic + OBOL:automatic respiratory system organ - OBOL:automatic + OBOL:automatic @@ -234249,8 +48379,8 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity. + GO:0007588 - http://orcid.org/0000-0002-6601-2165 @@ -234276,8 +48406,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -234323,6 +48453,8 @@ The modern definition of neurosecretion has evolved to include the release of an Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrates phyla. (...) There is now good reason to believe that, in vertebrates and invertebrates alike, blood cell lineages diverge from a common type of progenitor cell, the hemocytoblast.[well established][VHOG] + + AAO:0000046 BTO:0000089 CALOHA:TS-0079 @@ -234338,10 +48470,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D001769 MIAA:0000315 NCIT:C12434 + OpenCyc:Mx4rvVjI8JwpEbGdrcN5Y29ycA TAO:0000007 UMLS:C0005767 VHOG:0000224 - Wikipedia:Blood XAO:0000124 ZFA:0000007 galen:Blood @@ -234377,7 +48509,7 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/issues/1330 + @@ -234388,52 +48520,52 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN A fluid that is composed of blood plasma and erythrocytes. + + + FMA:9670 - Wikipedia:Blood - http://orcid.org/0000-0002-6601-2165 - https://github.com/obophenotype/uberon/issues/9 A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO] - 2012-08-14 + 2012-08-14 TAO:0000007 - TAO - ZFIN:curator + TAO + ZFIN:curator Highly specialized circulating tissue consisting of several types of cells suspended in a fluid medium known as plasma.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000046 - AAO - AAO:LAP + AAO + AAO:LAP relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO] - 2012-06-20 + 2012-06-20 AAO:0000046 - AAO + AAO Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrates phyla. (...) There is now good reason to believe that, in vertebrates and invertebrates alike, blood cell lineages diverge from a common type of progenitor cell, the hemocytoblast.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000224 - VHOG + VHOG + DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood cells and blood cell development in the animal kingdom. Annual review of cell and developmental biology (2006) - http://bgee.unil.ch/ @@ -234491,7 +48623,7 @@ The modern definition of neurosecretion has evolved to include the release of an Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs. - http://orcid.org/0000-0002-6601-2165 + @@ -234522,9 +48654,11 @@ The modern definition of neurosecretion has evolved to include the release of an The bone forming the forehead and roof of the eye orbit. - fused in humans, paired in other animals In the mouse the parietal originates from cephalic paraxial mesoderm (Jiang 2000; Morriss-Kay 2001), whereas in the chicken it is traced back to either mesodermal (Noden 1978) or neural crest (Couly 1992, 1993). + + + AAO:0000206 EMAPA:19016 FMA:52734 @@ -234532,28 +48666,25 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001466 MESH:D005624 NCIT:C32635 - SCTID:181793006 UMLS:C0016732 VHOG:0001324 VSAO:0000208 - Wikipedia:Frontal_bone frontal frontal bone os frontal uberon os frontale UBERON:0000209 - tetrapod frontal bone - http://upload.wikimedia.org/wikipedia/commons/9/97/Gray136.png - https://upload.wikimedia.org/wikipedia/commons/5/5b/Frontal_bone.png + http://upload.wikimedia.org/wikipedia/commons/9/97/Gray136.png + https://upload.wikimedia.org/wikipedia/commons/5/5b/Frontal_bone.png - FMA + FMA @@ -234564,16 +48695,16 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm The bone forming the forehead and roof of the eye orbit. - ISBN:0-683-40008-8 + + + ISBN:0-683-40008-8 MP:0000107 - PMID:7914451 - Wikipedia:Frontal_bone @@ -234587,6 +48718,14 @@ The modern definition of neurosecretion has evolved to include the release of an frontal AAO:0000206 + + + + frontal bone + FMA:52734 + MA:0001466 + + @@ -234599,14 +48738,14 @@ The modern definition of neurosecretion has evolved to include the release of an os frontal - Wikipedia:Frontal_bone + os frontale - Wikipedia:Frontal_bone + @@ -234634,21 +48773,14 @@ The modern definition of neurosecretion has evolved to include the release of an - . + + FMA:24293 - SCTID:281228008 - Wikipedia:Atlas_(anatomy)#Vertebral_foramen vertebral foramen of cervical vertebra 1 uberon UBERON:0000219 vertebral foramen of atlas - - - - . - Wikipedia:Atlas_(anatomy)#Vertebral_foramen - @@ -234670,6 +48802,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -234703,12 +48836,13 @@ The modern definition of neurosecretion has evolved to include the release of an The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital. + + + FMA:24939 MESH:D001269 NCIT:C32158 - SCTID:361831006 UMLS:C0004169 - Wikipedia:Atlanto-occipital_joint ncithesaurus:Atlanto-occipital_Joint-Atlanto articulatio atlanto-occipitalis atlanto occipital joint @@ -234720,7 +48854,7 @@ The modern definition of neurosecretion has evolved to include the release of an articulatio atlantooccipitalis UBERON:0000220 atlanto-occipital joint - http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray304.png + http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray304.png @@ -234731,13 +48865,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA-abduced-lr + FMA-abduced-lr The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital. - Wikipedia:Atlanto-occipital_joint + @@ -234761,7 +48895,7 @@ The modern definition of neurosecretion has evolved to include the release of an articulatio atlantooccipitalis - Wikipedia:Atlanto-occipital_joint + @@ -234781,7 +48915,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -234809,13 +48943,14 @@ The modern definition of neurosecretion has evolved to include the release of an A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath. TODO - add layer relations. 'tendon sheath' GAT in FMA. + + + BTO:0000051 FMA:45087 FMA:76715 NCIT:C96299 - SCTID:361885006 UMLS:C0224856 - Wikipedia:Tendon_sheath synovial tendon sheath uberon vagina tendinis @@ -234826,7 +48961,7 @@ The modern definition of neurosecretion has evolved to include the release of an A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath. - Wikipedia:Tendon_sheath + @@ -234844,7 +48979,7 @@ The modern definition of neurosecretion has evolved to include the release of an vagina tendinis - Wikipedia:Tendon_sheath + @@ -234865,6 +49000,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -234880,25 +49016,26 @@ The modern definition of neurosecretion has evolved to include the release of an Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula UBERON:0007011 + BILA:0000059 BTO:0000128 GAID:1294 MESH:D036703 OGEM:000006 - Wikipedia:Blastula + OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg blastula embryo uberon blastosphere UBERON:0000307 blastula - http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png + http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. - Wikipedia:Blastula + @@ -234910,7 +49047,7 @@ The modern definition of neurosecretion has evolved to include the release of an blastosphere - Wikipedia:Blastula + @@ -234940,6 +49077,7 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0003347 UBERON:0004981 + BTO:0000271 CALOHA:TS-0164 EFO:0003038 @@ -234947,7 +49085,6 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:14984 FMA:85388 MA:0003194 - SCTID:362157008 colon mucosa colon mucous membrane colonic mucosa @@ -234965,7 +49102,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells. - http://orcid.org/0000-0002-6601-2165 + @@ -234977,7 +49114,7 @@ The modern definition of neurosecretion has evolved to include the release of an colon mucous membrane - OBOL:automatic + OBOL:automatic @@ -234989,7 +49126,7 @@ The modern definition of neurosecretion has evolved to include the release of an large bowel mucosa - OBOL:automatic + OBOL:automatic @@ -235001,7 +49138,7 @@ The modern definition of neurosecretion has evolved to include the release of an mucosa of large bowel - OBOL:automatic + OBOL:automatic @@ -235030,12 +49167,12 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a duodenum [Automatically generated definition]. UBERON:0003348 + BTO:0000367 CALOHA:TS-0213 EMAPA:27235 FMA:14942 MA:0003207 - SCTID:362146003 doudenal mucosa duodenal mucous membrane mucosa of duodenum @@ -235050,7 +49187,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a duodenum [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -235068,13 +49205,13 @@ The modern definition of neurosecretion has evolved to include the release of an mucosa of duodenum - OBOL:automatic + OBOL:automatic mucous membrane of duodenum - OBOL:automatic + OBOL:automatic @@ -235110,7 +49247,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -235121,13 +49258,13 @@ The modern definition of neurosecretion has evolved to include the release of an - ISBN:0073040584 + ISBN:0073040584 The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin. - MGI:anna + MGI:anna @@ -235196,6 +49333,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -235218,7 +49356,7 @@ The modern definition of neurosecretion has evolved to include the release of an The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity). - http://orcid.org/0000-0002-6601-2165 + @@ -235257,10 +49395,10 @@ The modern definition of neurosecretion has evolved to include the release of an Bone marrow in which the fat cells predominate in the meshes of the reticular network. + + BTO:0000635 FMA:74596 - SCTID:328639002 - SCTID:5023006 medulla ossium flava yellow marrow uberon @@ -235272,7 +49410,7 @@ The modern definition of neurosecretion has evolved to include the release of an Bone marrow in which the fat cells predominate in the meshes of the reticular network. - http://medical-dictionary.thefreedictionary.com/Yellow+Marrow + @@ -235319,9 +49457,9 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm]. Note that some sources treat 'intestinal gland' as synonymous with crypts + BTO:0000640 FMA:15052 - SCTID:266297002 bowel mucosa gland bowel mucosa of organ gland bowel mucous membrane gland @@ -235367,133 +49505,133 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm]. - https://orcid.org/0000-0002-6601-2165 + bowel mucosa gland - OBOL:automatic + OBOL:automatic bowel mucosa of organ gland - OBOL:automatic + OBOL:automatic bowel mucous membrane gland - OBOL:automatic + OBOL:automatic bowel organ mucosa gland - OBOL:automatic + OBOL:automatic gland of bowel mucosa - OBOL:automatic + OBOL:automatic gland of bowel mucosa of organ - OBOL:automatic + OBOL:automatic gland of bowel mucous membrane - OBOL:automatic + OBOL:automatic gland of bowel organ mucosa - OBOL:automatic + OBOL:automatic gland of intestinal mucosa - OBOL:automatic + OBOL:automatic gland of intestine mucosa - OBOL:automatic + OBOL:automatic gland of intestine mucosa of organ - OBOL:automatic + OBOL:automatic gland of intestine mucous membrane - OBOL:automatic + OBOL:automatic gland of intestine organ mucosa - OBOL:automatic + OBOL:automatic gland of mucosa of bowel - OBOL:automatic + OBOL:automatic gland of mucosa of intestine - OBOL:automatic + OBOL:automatic gland of mucosa of organ of bowel - OBOL:automatic + OBOL:automatic gland of mucosa of organ of intestine - OBOL:automatic + OBOL:automatic gland of mucous membrane of bowel - OBOL:automatic + OBOL:automatic gland of mucous membrane of intestine - OBOL:automatic + OBOL:automatic gland of organ mucosa of bowel - OBOL:automatic + OBOL:automatic gland of organ mucosa of intestine - OBOL:automatic + OBOL:automatic @@ -235505,79 +49643,79 @@ The modern definition of neurosecretion has evolved to include the release of an intestinal mucosa gland - OBOL:automatic + OBOL:automatic intestine mucosa gland - OBOL:automatic + OBOL:automatic intestine mucosa of organ gland - OBOL:automatic + OBOL:automatic intestine mucous membrane gland - OBOL:automatic + OBOL:automatic intestine organ mucosa gland - OBOL:automatic + OBOL:automatic mucosa of bowel gland - OBOL:automatic + OBOL:automatic mucosa of intestine gland - OBOL:automatic + OBOL:automatic mucosa of organ of bowel gland - OBOL:automatic + OBOL:automatic mucosa of organ of intestine gland - OBOL:automatic + OBOL:automatic mucous membrane of bowel gland - OBOL:automatic + OBOL:automatic mucous membrane of intestine gland - OBOL:automatic + OBOL:automatic organ mucosa of bowel gland - OBOL:automatic + OBOL:automatic organ mucosa of intestine gland - OBOL:automatic + OBOL:automatic @@ -235585,7 +49723,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -235609,6 +49746,9 @@ The modern definition of neurosecretion has evolved to include the release of an mucosal FMA has mucosa vs region of mucosa; these are subtypes of Mucosa: Mucosa of gallbladder, tongue, .... The following are subtypes of Region of mucosa: Mucosa of zone of stomach, trachea, bronchus, dorsum of tongue.... Depends on whether the covered area is an organ or organ component. Uberon does not regard organ vs organ component as crucial distinction and thus collapses these into a single class deliberately + + + AEO:0000199 BTO:0000886 CALOHA:TS-2031 @@ -235619,9 +49759,8 @@ The modern definition of neurosecretion has evolved to include the release of an GAID:297 MESH:D009092 NCIT:C13166 - SCTID:361693009 + OpenCyc:Mx4rvmKNOpwpEbGdrcN5Y29ycA UMLS:C0026724 - Wikipedia:Mucous_membrane galen:Mucosa mucosa of organ mucosa of organ part @@ -235634,20 +49773,20 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0000344 mucosa - http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png - http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png + http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png + http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP]. - Wikipedia:Mucous_membrane + FMA has mucosa vs region of mucosa; these are subtypes of Mucosa: Mucosa of gallbladder, tongue, .... The following are subtypes of Region of mucosa: Mucosa of zone of stomach, trachea, bronchus, dorsum of tongue.... Depends on whether the covered area is an organ or organ component. Uberon does not regard organ vs organ component as crucial distinction and thus collapses these into a single class deliberately - FMA + FMA @@ -235695,10 +49834,15 @@ The modern definition of neurosecretion has evolved to include the release of an tunica mucosa - BTO:0000886 - Wikipedia:Mucous_membrane + + + + + tunica mucosa + BTO:0000886 + @@ -235723,7 +49867,8 @@ The modern definition of neurosecretion has evolved to include the release of an parenchymal Early in development the mammalian embryo has three distinct layers: ectoderm (external layer), endoderm (internal layer) and in between those two layers the middle layer or mesoderm. The parenchyma of most organs is of ectodermal (brain, skin) or endodermal origin (lungs, gastrointestinal tract, liver, pancreas). The parenchyma of a few organs (spleen, kidneys, heart) is of mesodermal origin. The stroma of all organs is of mesodermal origin the FMA definition is more restrictive, and limits this to solid organs. This would seem to cause problems for the lung parenchyma, except FMA classifies Lung as solid rather than cavitated - BTO:0001539 + + EHDAA:3015 EHDAA:3905 EHDAA:3999 @@ -235739,7 +49884,6 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:45732 NCIT:C74601 UMLS:C0933845 - Wikipedia:Parenchyma uberon UBERON:0000353 parenchyma @@ -235748,25 +49892,19 @@ The modern definition of neurosecretion has evolved to include the release of an Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues. - Wikipedia:Parenchyma + Early in development the mammalian embryo has three distinct layers: ectoderm (external layer), endoderm (internal layer) and in between those two layers the middle layer or mesoderm. The parenchyma of most organs is of ectodermal (brain, skin) or endodermal origin (lungs, gastrointestinal tract, liver, pancreas). The parenchyma of a few organs (spleen, kidneys, heart) is of mesodermal origin. The stroma of all organs is of mesodermal origin - WP + WP the FMA definition is more restrictive, and limits this to solid organs. This would seem to cause problems for the lung parenchyma, except FMA classifies Lung as solid rather than cavitated - FMA - - - - - BTO:0001539 - https://orcid.org/0000-0003-4423-4370 + FMA @@ -235791,6 +49929,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -235800,11 +49939,11 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a pharynx [Automatically generated definition]. UBERON:0003344 + BTO:0001047 EMAPA:26957 FMA:55031 MA:0003143 - SCTID:362121003 mucosa of organ of pharynx mucosa of pharynx mucous membrane of pharynx @@ -235824,63 +49963,68 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a pharynx [Automatically generated definition]. - OBOL:automatic + OBOL:automatic mucosa of organ of pharynx - OBOL:automatic + OBOL:automatic mucosa of pharynx - OBOL:automatic + OBOL:automatic mucous membrane of pharynx FMA:55031 - OBOL:automatic + + + + + mucous membrane of pharynx + OBOL:automatic organ mucosa of pharynx - OBOL:automatic + OBOL:automatic pharynx mucosa - OBOL:automatic + OBOL:automatic pharynx mucosa of organ - OBOL:automatic + OBOL:automatic pharynx mucous membrane - OBOL:automatic + OBOL:automatic pharynx organ mucosa - OBOL:automatic + OBOL:automatic tunica mucosa pharyngea FMA:55031 - FMA:TA + FMA:TA @@ -235895,6 +50039,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -235934,6 +50079,9 @@ The modern definition of neurosecretion has evolved to include the release of an The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO]. Gilbert fig11.32 has blastocyst has giving rise to ICM and trophoblast (which in this source is a synonym for trophectoderm) + + + BTO:0001099 CALOHA:TS-0076 EFO:0000295 @@ -235943,23 +50091,21 @@ The modern definition of neurosecretion has evolved to include the release of an GAID:1153 MESH:D001755 NCIT:C13739 - SCTID:308837009 UMLS:C1281743 - Wikipedia:Blastocyst uberon blastocystis blastula UBERON:0000358 blastocyst - https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg + https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO]. + GO:0001824 - Wikipedia:Blastocyst @@ -235971,7 +50117,7 @@ The modern definition of neurosecretion has evolved to include the release of an blastocystis - Wikipedia:Blastocyst + @@ -236011,10 +50157,10 @@ The modern definition of neurosecretion has evolved to include the release of an The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream. + + BTO:0001160 FMA:74595 - SCTID:328538003 - SCTID:75330005 medulla ossium rubra parenchymal red marrow red marrow @@ -236027,7 +50173,7 @@ The modern definition of neurosecretion has evolved to include the release of an The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream. - http://medical-dictionary.thefreedictionary.com/red+marrow + @@ -236040,7 +50186,7 @@ The modern definition of neurosecretion has evolved to include the release of an parenchymal red marrow - http://orcid.org/0000-0002-6601-2165 + @@ -236052,112 +50198,7 @@ The modern definition of neurosecretion has evolved to include the release of an parenchyma of none marrow marrow - http://orcid.org/0000-0002-6601-2165 - - - - - - - - - - - - - - - - - - - - - - - - - - - Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated). - BTO:0001335 - EHDAA:129 - EHDAA:91 - EMAPA:16068 - FMA:83040 - NCIT:C33918 - SCTID:256965005 - UMLS:C1135936 - Wikipedia:Syncytiotrophoblast - syncytial trophoblast - syntrophoblast layer - uberon - syncitiotrophoblast - syncitiotrophoblastus - syntrophoblast - UBERON:0000371 - syncytiotrophoblast - http://upload.wikimedia.org/wikipedia/commons/d/df/Gray36.png - - - - - - FMA - - - - - - - - - - - BTO - - - - - - - - - - - EMAPA - - - - - Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated). - Wikipedia:Syncytiotrophoblast - http://embryology.med.unsw.edu.au/Notes/placenta5.htm - - - - - UMLS:C1135936 - ncithesaurus:Syncytiotrophoblast - - - - - syncytial trophoblast - FMA:83040 - - - - - syntrophoblast layer - ISBN:0073040584 - - - - - syncitiotrophoblastus - Wikipedia:Syncytiotrophoblast - + @@ -236182,6 +50223,8 @@ The modern definition of neurosecretion has evolved to include the release of an Medial ramus (sensory) of the trigeminal nerve.[AAO] relationship loss: part_of trunk maxillary-mandibularis (AAO:0010669)[AAO] + + AAO:0010670 BTO:0001378 EHDAA2:0002087 @@ -236190,9 +50233,8 @@ The modern definition of neurosecretion has evolved to include the release of an GAID:836 MA:0001103 MESH:D008442 - SCTID:280211001 + OpenCyc:Mx4rvWNU9JwpEbGdrcN5Y29ycA VHOG:0001346 - Wikipedia:Maxillary_nerve maxillary division [V2] maxillary division [Vb] maxillary division of fifth cranial nerve @@ -236214,31 +50256,31 @@ The modern definition of neurosecretion has evolved to include the release of an maxillary nerve - http://upload.wikimedia.org/wikipedia/commons/a/a9/Gray779.png + http://upload.wikimedia.org/wikipedia/commons/a/a9/Gray779.png The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses. + MP:0009799 - Wikipedia:Maxillary_nerve Medial ramus (sensory) of the trigeminal nerve.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010670 - AAO - AAO:EJS + AAO + AAO:EJS relationship loss: part_of trunk maxillary-mandibularis (AAO:0010669)[AAO] - 2012-06-20 + 2012-06-20 AAO:0010670 - AAO + AAO @@ -236287,7 +50329,7 @@ The modern definition of neurosecretion has evolved to include the release of an nervus maxillaris [v2] FMA:52724 - FMA:TA + FMA:TA @@ -236295,7 +50337,7 @@ The modern definition of neurosecretion has evolved to include the release of an nervus maxillaris [vb] FMA:52724 - FMA:TA + FMA:TA @@ -236326,7 +50368,7 @@ The modern definition of neurosecretion has evolved to include the release of an n. maxillaris - Wikipedia:Maxillary_nerve + @@ -236366,9 +50408,9 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a respiratory airway. + BTO:0001390 FMA:7471 - SCTID:660006 mucosa of organ of trachea mucosa of organ of windpipe mucosa of trachea @@ -236396,80 +50438,85 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a respiratory airway. - OBOL:automatic + OBOL:automatic mucosa of organ of trachea - OBOL:automatic + OBOL:automatic mucosa of organ of windpipe - OBOL:automatic + OBOL:automatic mucosa of trachea - OBOL:automatic + OBOL:automatic mucosa of windpipe - OBOL:automatic + OBOL:automatic mucous membrane of trachea FMA:7471 - OBOL:automatic + + + + + mucous membrane of trachea + OBOL:automatic mucous membrane of windpipe - OBOL:automatic + OBOL:automatic organ mucosa of trachea - OBOL:automatic + OBOL:automatic organ mucosa of windpipe - OBOL:automatic + OBOL:automatic trachea mucosa - OBOL:automatic + OBOL:automatic trachea mucosa of organ - OBOL:automatic + OBOL:automatic trachea mucous membrane - OBOL:automatic + OBOL:automatic trachea organ mucosa - OBOL:automatic + OBOL:automatic @@ -236488,32 +50535,32 @@ The modern definition of neurosecretion has evolved to include the release of an tunica mucosa tracheae FMA:7471 - FMA:TA + FMA:TA windpipe mucosa - OBOL:automatic + OBOL:automatic windpipe mucosa of organ - OBOL:automatic + OBOL:automatic windpipe mucous membrane - OBOL:automatic + OBOL:automatic windpipe organ mucosa - OBOL:automatic + OBOL:automatic @@ -236532,6 +50579,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -236570,7 +50618,6 @@ The modern definition of neurosecretion has evolved to include the release of an The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]. consider whether this should be restricted to skeletal musculature. See https://github.com/obophenotype/uberon/issues/77 - Anatomical system that consists of the muscles of the body.[VSAO] we place the MA term musculature here, rather than under uberon:musculature, as this seems more appropriate given the structure of MA AAO:0000307 @@ -236579,6 +50626,7 @@ The modern definition of neurosecretion has evolved to include the release of an BTO:0001485 EFO:0000801 EMAPA:35578 + FBbt:00005069 FMA:72954 MA:0002888 MAT:0000025 @@ -236596,7 +50644,6 @@ The modern definition of neurosecretion has evolved to include the release of an muskelsystem UBERON:0000383 - musculature of body @@ -236610,16 +50657,16 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that consists of the muscles of the body.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000033 - VSAO + VSAO VSAO:curator we place the MA term musculature here, rather than under uberon:musculature, as this seems more appropriate given the structure of MA - MA + MA @@ -236676,6 +50723,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -236696,11 +50744,11 @@ The modern definition of neurosecretion has evolved to include the release of an Tissue that surrounds the lens nucleus. + BTO:0001632 CALOHA:TS-0542 FMA:58970 MESH:D007904 - SCTID:280626006 cortex of lens uberon UBERON:0000389 @@ -236711,7 +50759,7 @@ The modern definition of neurosecretion has evolved to include the release of an Tissue that surrounds the lens nucleus. - http://www.thefreedictionary.com/lens+cortex + @@ -236737,6 +50785,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -236758,10 +50807,10 @@ The modern definition of neurosecretion has evolved to include the release of an The core of the crystalline lens, surrounded by the cortex. + BTO:0001633 FMA:58971 MESH:D007907 - SCTID:280628007 nucleus of lens uberon UBERON:0000390 @@ -236807,12 +50856,12 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a colon [Automatically generated definition]. Intestinal epithelium which lines the lumen of the posterior intestine.[TAO] + BTO:0001709 CALOHA:TS-0163 EMAPA:18941 FMA:17302 MA:0003195 - SCTID:42978003 TAO:0005128 ZFA:0005128 colon epithelial tissue @@ -236834,65 +50883,70 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a colon [Automatically generated definition]. - OBOL:automatic + OBOL:automatic Intestinal epithelium which lines the lumen of the posterior intestine.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005128 - TAO - ZFIN:curator + TAO + ZFIN:curator colon epithelial tissue - OBOL:automatic + OBOL:automatic colon epithelium FMA:17302 - OBOL:automatic + + + + + colon epithelium + OBOL:automatic epithelial tissue of colon - OBOL:automatic + OBOL:automatic epithelial tissue of large bowel - OBOL:automatic + OBOL:automatic epithelium of colon - OBOL:automatic + OBOL:automatic epithelium of large bowel - OBOL:automatic + OBOL:automatic large bowel epithelial tissue - OBOL:automatic + OBOL:automatic large bowel epithelium - OBOL:automatic + OBOL:automatic @@ -236938,23 +50992,23 @@ The modern definition of neurosecretion has evolved to include the release of an A gland in which the principal secretory cells are serous secreting cells. glands that secrete watery albuminous material that often contains enzymes[MP:0008052]. + BTO:0001837 EMAPA:37950 FMA:62889 - Wikipedia:Serous_gland uberon UBERON:0000409 serous gland - http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png + http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png A gland in which the principal secretory cells are serous secreting cells. - http://orcid.org/0000-0002-6601-2165 - http://www.siumed.edu/~dking2/intro/glands.htm + + @@ -236966,7 +51020,229 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37950 - MA:th + MA:th + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a bronchus [Automatically generated definition]. + + BTO:0001846 + FMA:62652 + bronchi mucosa + bronchi mucosa of organ + bronchi mucous membrane + bronchi organ mucosa + bronchial trunk mucosa + bronchial trunk mucosa of organ + bronchial trunk mucous membrane + bronchial trunk organ mucosa + bronchus mucosa + bronchus mucosa of organ + bronchus mucous membrane + bronchus organ mucosa + mucosa of bronchi + mucosa of bronchial trunk + mucosa of bronchus + mucosa of organ of bronchi + mucosa of organ of bronchial trunk + mucosa of organ of bronchus + mucous membrane of bronchi + mucous membrane of bronchial trunk + mucous membrane of bronchus + organ mucosa of bronchi + organ mucosa of bronchial trunk + organ mucosa of bronchus + tunica mucosa bronchi + uberon + UBERON:0000410 + bronchial mucosa + + + + + A mucosa that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + + + + + bronchi mucosa + OBOL:automatic + + + + + bronchi mucosa of organ + OBOL:automatic + + + + + bronchi mucous membrane + OBOL:automatic + + + + + bronchi organ mucosa + OBOL:automatic + + + + + bronchial trunk mucosa + OBOL:automatic + + + + + bronchial trunk mucosa of organ + OBOL:automatic + + + + + bronchial trunk mucous membrane + OBOL:automatic + + + + + bronchial trunk organ mucosa + OBOL:automatic + + + + + bronchus mucosa + OBOL:automatic + + + + + bronchus mucosa of organ + OBOL:automatic + + + + + bronchus mucous membrane + OBOL:automatic + + + + + bronchus organ mucosa + OBOL:automatic + + + + + mucosa of bronchi + OBOL:automatic + + + + + mucosa of bronchial trunk + OBOL:automatic + + + + + mucosa of bronchus + OBOL:automatic + + + + + mucosa of organ of bronchi + OBOL:automatic + + + + + mucosa of organ of bronchial trunk + OBOL:automatic + + + + + mucosa of organ of bronchus + OBOL:automatic + + + + + mucous membrane of bronchi + OBOL:automatic + + + + + mucous membrane of bronchial trunk + OBOL:automatic + + + + + mucous membrane of bronchus + FMA:62652 + + + + + mucous membrane of bronchus + OBOL:automatic + + + + + organ mucosa of bronchi + OBOL:automatic + + + + + organ mucosa of bronchial trunk + OBOL:automatic + + + + + organ mucosa of bronchus + OBOL:automatic + + + + + tunica mucosa bronchi + FMA:62652 + FMA:TA + @@ -237006,11 +51282,11 @@ The modern definition of neurosecretion has evolved to include the release of an A gland in which the principal secretory cells are mucus secreting cells. In frogs and salamanders, this is the smaller of the two types of gland, the other being the granular (poison) gland. In these species the mucous gland is a cluster of cells that release secretion into a common duct[Kardong] + AAO:0010601 BTO:0001979 EMAPA:37913 FMA:62888 - Wikipedia:Mucous_gland glandula mucosa uberon muciparous gland @@ -237020,33 +51296,33 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0000414 mucous gland - http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png + http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png A gland in which the principal secretory cells are mucus secreting cells. - http://orcid.org/0000-0002-6601-2165 - http://www.siumed.edu/~dking2/intro/glands.htm + + In frogs and salamanders, this is the smaller of the two types of gland, the other being the granular (poison) gland. In these species the mucous gland is a cluster of cells that release secretion into a common duct[Kardong] NCBITaxon:8292 - ISBN:0073040584 + ISBN:0073040584 EMAPA:37913 - MA:th + MA:th glandula mucosa - Wikipedia:Mucous_gland + @@ -237093,7 +51369,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical wall that is part of an artery [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -237128,9 +51404,9 @@ The modern definition of neurosecretion has evolved to include the release of an A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP]. trabecular + BTO:0002501 FMA:85273 - Wikipedia:Trabecula trabeculae uberon UBERON:0000440 @@ -237142,14 +51418,14 @@ The modern definition of neurosecretion has evolved to include the release of an A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP]. + GO:0060343 - Wikipedia:Trabecula trabeculae - + @@ -237179,6 +51455,7 @@ The modern definition of neurosecretion has evolved to include the release of an BTO has two distunct classes, with exocrine glandular secretion a subtype of secretion - however, all examples in BTO directly under secretion appear to be exocrine gland secretions UBERON:0006540 secretion + AEO:0001005 BTO:0002977 BTO:0002979 @@ -237204,13 +51481,13 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of organism substance that is produced by exocrine glands. - http://orcid.org/0000-0002-6601-2165 + BTO has two distunct classes, with exocrine glandular secretion a subtype of secretion - however, all examples in BTO directly under secretion appear to be exocrine gland secretions - BTO + BTO @@ -237262,9 +51539,6 @@ The modern definition of neurosecretion has evolved to include the release of an Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. - - - AAO:0010839 AEO:0000004 BILA:0000004 @@ -237291,7 +51565,6 @@ The modern definition of neurosecretion has evolved to include the release of an portion of organism substance uberon UBERON:0000463 - organism substance @@ -237311,7 +51584,7 @@ The modern definition of neurosecretion has evolved to include the release of an Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. - http://orcid.org/0000-0001-9114-8737 + @@ -237357,11 +51630,9 @@ The modern definition of neurosecretion has evolved to include the release of an Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures. - - - lumen space + AAO:0010110 AEO:0000005 BILA:0000005 @@ -237381,7 +51652,6 @@ The modern definition of neurosecretion has evolved to include the release of an uberon anatomical spaces UBERON:0000464 - anatomical space @@ -237389,7 +51659,7 @@ The modern definition of neurosecretion has evolved to include the release of an Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures. - http://orcid.org/0000-0001-9114-8737 + @@ -237402,7 +51672,7 @@ The modern definition of neurosecretion has evolved to include the release of an anatomical spaces ZFA:0001643 - + @@ -237412,11 +51682,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Anatomical entity that has mass. - - - AAO:0010264 AEO:0000006 BILA:0000006 @@ -237430,7 +51696,6 @@ The modern definition of neurosecretion has evolved to include the release of an VHOG:0001721 uberon UBERON:0000465 - material anatomical entity @@ -237438,7 +51703,7 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical entity that has mass. - http://orcid.org/0000-0001-9114-8737 + @@ -237449,9 +51714,6 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical entity that has no mass. - - - AAO:0010265 AEO:0000007 BILA:0000007 @@ -237466,7 +51728,6 @@ The modern definition of neurosecretion has evolved to include the release of an immaterial physical anatomical entity uberon UBERON:0000466 - immaterial anatomical entity @@ -237474,7 +51735,7 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical entity that has no mass. - http://orcid.org/0000-0001-9114-8737 + @@ -237502,11 +51763,10 @@ The modern definition of neurosecretion has evolved to include the release of an Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function. - - - - system + + + AAO:0000007 AEO:0000011 BILA:0000011 @@ -237521,17 +51781,15 @@ The modern definition of neurosecretion has evolved to include the release of an FBbt:00004856 FMA:7149 HAO:0000011 - IDOMAL:0002460 MA:0000003 NCIT:C12919 - SCTID:278195005 + OpenCyc:Mx4rCWM0QCtDEdyAAADggVbxzQ TAO:0001439 TGMA:0001831 UMLS:C0460002 VHOG:0001725 WBbt:0005746 WBbt:0005763 - Wikipedia:Organ_system XAO:0003002 ZFA:0001439 galen:AnatomicalSystem @@ -237541,8 +51799,6 @@ The modern definition of neurosecretion has evolved to include the release of an uberon anatomical systems UBERON:0000467 - - @@ -237561,12 +51817,6 @@ The modern definition of neurosecretion has evolved to include the release of an system GO:0048731 - - - - IDOMAL:0002460 - https://orcid.org/0000-0003-4423-4370 - @@ -237590,7 +51840,7 @@ The modern definition of neurosecretion has evolved to include the release of an anatomical systems ZFA:0001439 - + @@ -237601,11 +51851,10 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure that is an individual member of a species and consists of more than one cell. TODO - split body and mc organism? body continues after death stage - - - organismal organism + + AAO:0010026 AEO:0000191 BILA:0000012 @@ -237623,13 +51872,11 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:256135 HAO:0000012 NCIT:C13041 - SCTID:243928005 TADS:0000001 TAO:0001094 TGMA:0001832 VHOG:0000671 WBbt:0007833 - Wikipedia:Multi-cellular_organism XAO:0003004 ZFA:0001094 galen:Organism @@ -237641,7 +51888,6 @@ The modern definition of neurosecretion has evolved to include the release of an whole body whole organism UBERON:0000468 - @@ -237652,9 +51898,9 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure that is an individual member of a species and consists of more than one cell. + + CARO:0000012 - Wikipedia:Multi-cellular_organism - http://orcid.org/0000-0001-9114-8737 @@ -237732,15 +51978,15 @@ The modern definition of neurosecretion has evolved to include the release of an Multi-tissue structure that is part of a compound organ. + CARO:0000019 - http://orcid.org/0000-0001-9114-8737 compound organ components ZFA:0001489 - + @@ -237768,6 +52014,9 @@ The modern definition of neurosecretion has evolved to include the release of an The organs and associated structures associated with bearing offspring in a female animal. By far, sexual reproduction is the more common pattern among living vertebrate forms and its widespread occurrence suggests that it is the plesiomorphic, or primitive, reproductive mode among the vertebrates.[well established][VHOG] + + + BTO:0000083 CALOHA:TS-1303 EFO:0000969 @@ -237783,11 +52032,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D005836 MIAA:0000028 NCIT:C12402 - SCTID:361386004 + OpenCyc:Mx4rvVipTZwpEbGdrcN5Y29ycA TGMA:0000635 UMLS:C0700038 VHOG:0000726 - Wikipedia:Female_genitalia WikipediaCategory:Female_reproductive_system XAO:0000156 female organism genitalia @@ -237807,25 +52055,25 @@ The modern definition of neurosecretion has evolved to include the release of an female reproductive system - http://upload.wikimedia.org/wikipedia/commons/6/68/Scheme_female_reproductive_system-en.svg + http://upload.wikimedia.org/wikipedia/commons/6/68/Scheme_female_reproductive_system-en.svg The organs and associated structures associated with bearing offspring in a female animal. + + MP:0001119 - Wikipedia:Female_genitalia - http://orcid.org/0000-0002-6601-2165 By far, sexual reproduction is the more common pattern among living vertebrate forms and its widespread occurrence suggests that it is the plesiomorphic, or primitive, reproductive mode among the vertebrates.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000726 - VHOG + VHOG + ISBN:978-0792383369 Lombardi J, Comparative vertebrate reproduction (1998) p.43 - http://bgee.unil.ch/ @@ -237837,32 +52085,32 @@ The modern definition of neurosecretion has evolved to include the release of an female organism genitalia - OBOL:automatic + OBOL:automatic female organism reproductive system - OBOL:automatic + OBOL:automatic genitalia of female organism - OBOL:automatic + OBOL:automatic reproductive system of female organism - OBOL:automatic + OBOL:automatic female genitals XAO:0000156 - + @@ -237897,9 +52145,8 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument. Reflects CARO2. todo - check the inclusion of FMA 'cardinal body part here', and check child terms for consistency - - - + + AAO:0010053 AEO:0000032 BILA:0000032 @@ -237917,11 +52164,11 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D001829 MIAA:0000293 NCIT:C32221 + OpenCyc:Mx4rvViAHJwpEbGdrcN5Y29ycA TAO:0001308 TGMA:0001840 UMLS:C0229962 VHOG:0001758 - Wikipedia:Body_part XAO:0003013 ZFA:0001308 galen:BodyPart @@ -237931,7 +52178,6 @@ The modern definition of neurosecretion has evolved to include the release of an body region cardinal body part UBERON:0000475 - @@ -237948,9 +52194,9 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument. + CARO:0000032 CARO:DOS - http://orcid.org/0000-0001-9114-8737 @@ -237985,9 +52231,6 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue. - - - AAO:0010268 AEO:0000040 BILA:0000040 @@ -238003,7 +52246,6 @@ The modern definition of neurosecretion has evolved to include the release of an uberon acellular anatomical structures UBERON:0000476 - acellular anatomical structure @@ -238017,14 +52259,14 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue. - http://orcid.org/0000-0001-9114-8737 + acellular anatomical structures ZFA:0000382 - + @@ -238032,31 +52274,33 @@ The modern definition of neurosecretion has evolved to include the release of an - - Anatomical group whose component anatomical structures lie in close proximity to each other. - - - + + Anatomical group that has its parts adjacent to one another. + Will be obsoleted in CARO v2 [https://github.com/obophenotype/caro/issues/3] + AAO:0010009 + AEO:0000041 + BILA:0000041 + CARO:0000041 + EHDAA2:0003041 FBbt:00007277 - IDOMAL:0002461 + FMA:49443 + HAO:0000041 + TADS:0000605 + TAO:0001478 + TGMA:0001842 VHOG:0001737 + XAO:0003160 + ZFA:0001478 uberon UBERON:0000477 - anatomical cluster - Anatomical group whose component anatomical structures lie in close proximity to each other. - FBbt:00007277 - - - - - IDOMAL:0002461 - https://orcid.org/0000-0003-4423-4370 + Anatomical group that has its parts adjacent to one another. + @@ -238075,6 +52319,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -238083,6 +52328,8 @@ The modern definition of neurosecretion has evolved to include the release of an A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis. + + AAO:0010020 AEO:0000042 BILA:0000042 @@ -238094,7 +52341,6 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:85537 HAO:0000042 NCIT:C34055 - SCTID:314908006 TAO:0000020 TGMA:0001843 UMLS:C1282438 @@ -238116,9 +52362,9 @@ The modern definition of neurosecretion has evolved to include the release of an A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis. + + CARO:DOS - http://orcid.org/0000-0001-9114-8737 - https://cedar.bio.indiana.edu/trac/env/ontologies/ticket/279 @@ -238131,7 +52377,7 @@ The modern definition of neurosecretion has evolved to include the release of an extraembryonic structures ZFA:0000020 - + @@ -238154,9 +52400,7 @@ The modern definition of neurosecretion has evolved to include the release of an Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation. changed label and definition to reflect CARO2 - - - + AAO:0000607 AAO:0010054 AEO:0000043 @@ -238185,7 +52429,6 @@ The modern definition of neurosecretion has evolved to include the release of an simple tissue uberon UBERON:0000479 - tissue @@ -238234,9 +52477,6 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types. - - - AAO:0010048 AEO:0000055 BILA:0000055 @@ -238252,7 +52492,6 @@ The modern definition of neurosecretion has evolved to include the release of an uberon multi-tissue structures UBERON:0000481 - multi-tissue structure @@ -238266,15 +52505,15 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types. + CARO:0000055 - http://orcid.org/0000-0001-9114-8737 multi-tissue structures ZFA:0001488 - + @@ -238301,7 +52540,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -238318,7 +52556,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -238330,6 +52568,9 @@ The modern definition of neurosecretion has evolved to include the release of an Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]. The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG] epithelial + + + AAO:0000144 AAO:0010055 AEO:0000066 @@ -238346,11 +52587,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0003060 MESH:D004848 NCIT:C12710 - SCTID:31610004 TAO:0001486 UMLS:C0014609 VHOG:0000387 - Wikipedia:Epithelium XAO:0003045 ZFA:0001486 epithelial tissue @@ -238362,35 +52601,24 @@ The modern definition of neurosecretion has evolved to include the release of an Editor note: surface epithelium may contain non-epithelial cells, such as melanocytes, lymphocytes and dendritic cells, within the sheet of epithelial cells. Do we consider these part of the epithelium, or located-in it? epithelium - https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg + https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg - - - - - - - - - - http://palaeos.com/metazoa/porifera/homoscleromorpha.html - Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]. - Wikipedia:Epithelium - http://orcid.org/0000-0001-9114-8737 + + The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000387 - VHOG + VHOG + ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.59 - http://bgee.unil.ch/ @@ -238414,6 +52642,8 @@ The modern definition of neurosecretion has evolved to include the release of an Unilaminar epithelium that consists of a single layer of cuboidal cells. needs to be synchronized with CL - there is no distinct cuboidal cell in CL + + AAO:0010064 AEO:0000067 BILA:0000067 @@ -238424,7 +52654,6 @@ The modern definition of neurosecretion has evolved to include the release of an NCIT:C33553 TAO:0001497 UMLS:C0836134 - Wikipedia:Simple_cuboidal_epithelium XAO:0004009 ZFA:0001497 epithelium simplex cuboideum @@ -238434,14 +52663,14 @@ The modern definition of neurosecretion has evolved to include the release of an simple cuboidal epithelium - http://upload.wikimedia.org/wikipedia/commons/d/d0/Gray1133.png + http://upload.wikimedia.org/wikipedia/commons/d/d0/Gray1133.png Unilaminar epithelium that consists of a single layer of cuboidal cells. - Wikipedia:Simple_cuboidal_epithelium - http://orcid.org/0000-0001-9114-8737 + + @@ -238454,7 +52683,7 @@ The modern definition of neurosecretion has evolved to include the release of an simple cuboidal epithelia ZFA:0001497 - + @@ -238467,6 +52696,9 @@ The modern definition of neurosecretion has evolved to include the release of an Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA]. columnar epithelium columnar epithlium + + + AAO:0010063 AEO:0000068 BILA:0000068 @@ -238476,10 +52708,8 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:45567 HAO:0000068 NCIT:C33552 - SCTID:32210007 TAO:0001496 UMLS:C0836135 - Wikipedia:Simple_columnar_epithelium XAO:0004008 ZFA:0001496 epithelium simplex columnare @@ -238490,15 +52720,15 @@ The modern definition of neurosecretion has evolved to include the release of an simple columnar epithelium - http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray1059.png + http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray1059.png Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA]. - FMA:FMA - Wikipedia:Simple_columnar_epithelium - http://orcid.org/0000-0001-9114-8737 + + + FMA:FMA @@ -238523,7 +52753,7 @@ The modern definition of neurosecretion has evolved to include the release of an simple columnar epithelia ZFA:0001496 - + @@ -238534,6 +52764,9 @@ The modern definition of neurosecretion has evolved to include the release of an Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]. Epithelium that consists of more than one layer of epithelial cells.[CARO] + + + AAO:0010059 AEO:0000069 BILA:0000069 @@ -238543,10 +52776,8 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:45562 HAO:0000069 NCIT:C33622 - SCTID:309044005 TAO:0001494 UMLS:C0682575 - Wikipedia:Stratified_epithelium XAO:0004006 ZFA:0001494 stratified epithelium @@ -238561,19 +52792,19 @@ The modern definition of neurosecretion has evolved to include the release of an Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]. - FMA:FMA - Wikipedia:Stratified_epithelium - http://orcid.org/0000-0001-9114-8737 + + + FMA:FMA Epithelium that consists of more than one layer of epithelial cells.[CARO] - 2012-06-20 + 2012-06-20 CARO:0000069 CARO + FMA:45562 - http://orcid.org/0000-0001-9114-8737 @@ -238614,6 +52845,8 @@ The modern definition of neurosecretion has evolved to include the release of an Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]. Unilaminar epithelium that consists of a single layer of squamous cells.[CARO] + + AAO:0010066 AEO:0000070 BILA:0000070 @@ -238625,7 +52858,6 @@ The modern definition of neurosecretion has evolved to include the release of an NCIT:C13178 TAO:0001498 UMLS:C0836133 - Wikipedia:Simple_squamous_epithelium XAO:0004010 ZFA:0001498 epithelium simplex squamosum @@ -238635,25 +52867,25 @@ The modern definition of neurosecretion has evolved to include the release of an simple squamous epithelium - https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg + https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]. + + FMA:45565 - Wikipedia:Simple_squamous_epithelium - http://orcid.org/0000-0001-9114-8737 Unilaminar epithelium that consists of a single layer of squamous cells.[CARO] - 2012-06-20 + 2012-06-20 CARO:0000070 CARO + FMA:45565 - http://orcid.org/0000-0001-9114-8737 @@ -238666,7 +52898,7 @@ The modern definition of neurosecretion has evolved to include the release of an simple squamous epithelia ZFA:0001498 - + @@ -238697,14 +52929,14 @@ The modern definition of neurosecretion has evolved to include the release of an Epithelium that consists of epithelial cells not arranged in one ore more layers. - http://orcid.org/0000-0001-9114-8737 + atypical epithelia ZFA:0001493 - + @@ -238756,7 +52988,7 @@ The modern definition of neurosecretion has evolved to include the release of an Compound organ that contains one or more macroscopic anatomical spaces. - http://orcid.org/0000-0001-9114-8737 + @@ -238769,7 +53001,7 @@ The modern definition of neurosecretion has evolved to include the release of an cavitated compound organs ZFA:0001490 - + @@ -238781,6 +53013,8 @@ The modern definition of neurosecretion has evolved to include the release of an Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]. consider adding disjointness axiom between unilaminar and multilaminar - but note that this will render EHDAA2:0003244 (chorionic trophoblast) unsatisfiable Epithelium that consists of a single layer of epithelial cells.[CARO] + + AAO:0010062 AEO:0000073 BILA:0000073 @@ -238790,7 +53024,6 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:45561 HAO:0000073 NCIT:C33554 - SCTID:309043004 TAO:0001495 UMLS:C0682574 XAO:0004007 @@ -238806,18 +53039,18 @@ The modern definition of neurosecretion has evolved to include the release of an Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]. + FMA:45561 - http://orcid.org/0000-0001-9114-8737 Epithelium that consists of a single layer of epithelial cells.[CARO] - 2012-06-20 + 2012-06-20 CARO:0000073 CARO + FMA:45561 - http://orcid.org/0000-0001-9114-8737 @@ -238836,7 +53069,7 @@ The modern definition of neurosecretion has evolved to include the release of an unilaminar epithelia ZFA:0001495 - + @@ -238867,14 +53100,16 @@ The modern definition of neurosecretion has evolved to include the release of an Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water. mucoid mucous + + CALOHA:TS-2144 ENVO:02000040 FMA:66938 GAID:1164 MESH:D009093 NCIT:C13259 + OpenCyc:Mx4rvVjHq5wpEbGdrcN5Y29ycA UMLS:C0026727 - Wikipedia:Mucus galen:Mucus uberon UBERON:0000912 @@ -238884,7 +53119,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water. - Wikipedia:Mucus + @@ -238909,6 +53144,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -238922,11 +53158,11 @@ The modern definition of neurosecretion has evolved to include the release of an + + EMAPA:35862 FMA:259209 MA:0000022 - SCTID:302551006 - Wikipedia:Thorax thorax uberon anterior subdivision of trunk @@ -238940,13 +53176,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Subdivision of trunk that lies between the head and the abdomen. - http://orcid.org/0000-0002-6601-2165 + @@ -238983,6 +53219,8 @@ The modern definition of neurosecretion has evolved to include the release of an Vertebrate specific. In arthropods 'abdomen' is the most distal section of the body which lies behind the thorax or cephalothorax. If need be we can introduce some grouping class abdominal celiac + + BTO:0000020 CALOHA:TS-0001 EFO:0000968 @@ -238994,8 +53232,7 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000298 MESH:D000005 MIAA:0000298 - SCTID:302553009 - Wikipedia:Abdomen + OpenCyc:Mx4rvVjgyZwpEbGdrcN5Y29ycA galen:Abdomen abdominopelvic region abdominopelvis @@ -239018,13 +53255,13 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column. - http://orcid.org/0000-0002-6601-2165 + @@ -239075,6 +53312,10 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. embryonic Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo + + + + AAO:0011035 AEO:0000169 BILA:0000056 @@ -239089,19 +53330,16 @@ The modern definition of neurosecretion has evolved to include the release of an FBbt:00000052 FMA:69068 GAID:963 - IDOMAL:0000646 MAT:0000226 MESH:D004622 MIAA:0000019 NCIT:C28147 OGEM:000001 - SCTID:57991002 + OpenCyc:Mx4rwP1ceZwpEbGdrcN5Y29ycA UMLS:C0013935 VHOG:0001766 - Wikipedia:Embryo XAO:0000113 ZFA:0000103 - http://neurolex.org/wiki/Category:Embryonic_organism embryonic organism uberon developing organism @@ -239113,17 +53351,17 @@ The modern definition of neurosecretion has evolved to include the release of an embryo https://github.com/obophenotype/uberon/issues/503 - https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg + https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. + BTO:0000379 FB:FBrf0039741 FB:FBrf0041814 GO:0009790 - Wikipedia:Embryo @@ -239131,12 +53369,6 @@ The modern definition of neurosecretion has evolved to include the release of an Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo ZFA - - - - IDOMAL:0000646 - https://orcid.org/0000-0003-4423-4370 - @@ -239183,6 +53415,9 @@ The modern definition of neurosecretion has evolved to include the release of an A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm. The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] embryonic tissue + + + AAO:0000480 BILA:0000035 BTO:0000556 @@ -239197,7 +53432,6 @@ The modern definition of neurosecretion has evolved to include the release of an UMLS:C0920502 UMLS:C1708239 VHOG:0001223 - Wikipedia:Germ_layer XAO:0003011 ZFA:0001122 germinal layer @@ -239215,18 +53449,18 @@ The modern definition of neurosecretion has evolved to include the release of an A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm. - Wikipedia:Germ_layer - https://github.com/obophenotype/uberon/issues/203 + + The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001223 - VHOG + VHOG + ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722 - http://bgee.unil.ch/ @@ -239288,6 +53522,9 @@ The modern definition of neurosecretion has evolved to include the release of an Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO] The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] ectodermal + + + AAO:0000137 BILA:0000036 BTO:0000315 @@ -239304,11 +53541,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D004475 MIAA:0000173 NCIT:C12703 - SCTID:362851007 TAO:0000016 UMLS:C0013574 VHOG:0000153 - Wikipedia:Ectoderm XAO:0000001 ZFA:0000016 embryonic ectoderm @@ -239319,7 +53554,7 @@ The modern definition of neurosecretion has evolved to include the release of an ectoderm - http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png + http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png @@ -239330,32 +53565,32 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. - Wikipedia:Ectoderm + Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000137 - AAO - AAO:EJS + AAO + AAO:EJS The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000153 - VHOG + VHOG + ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722 - http://bgee.unil.ch/ @@ -239397,6 +53632,9 @@ The modern definition of neurosecretion has evolved to include the release of an Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] endodermal + + + AAO:0000139 BILA:0000038 BTO:0000800 @@ -239412,11 +53650,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D004707 MIAA:0000175 NCIT:C12706 - SCTID:362855003 TAO:0000017 UMLS:C0014144 VHOG:0000154 - Wikipedia:Endoderm XAO:0000090 ZFA:0000017 uberon @@ -239427,8 +53663,8 @@ The modern definition of neurosecretion has evolved to include the release of an endoderm - http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png - http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png + http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png + http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png @@ -239439,23 +53675,23 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. - Wikipedia:Endoderm + The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000154 - VHOG + VHOG + ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722 - http://bgee.unil.ch/ @@ -239467,7 +53703,7 @@ The modern definition of neurosecretion has evolved to include the release of an entoderm - DOI:10.5962/bhl.title.1013 + @@ -239524,6 +53760,9 @@ The modern definition of neurosecretion has evolved to include the release of an mesodermal sponges do not seem to have a mesoderm and accordingly Amphimedon lacks transcription factors involved in mesoderm development (Fkh, Gsc, Twist, Snail)[http://www.nature.com/nature/journal/v466/n7307/full/nature09201.html]. Mesoderm may not be homologous across verteberates UBERON:0003263 + + + AAO:0000304 BILA:0000037 BTO:0000839 @@ -239542,11 +53781,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D008648 MIAA:0000174 NCIT:C12750 - SCTID:362854004 TAO:0000041 UMLS:C0025485 VHOG:0000152 - Wikipedia:Mesoderm XAO:0000050 ZFA:0000041 uberon @@ -239559,7 +53796,7 @@ The modern definition of neurosecretion has evolved to include the release of an mesoderm - http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png + http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png @@ -239576,38 +53813,38 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN The middle germ layer of the embryo, between the endoderm and ectoderm. - Wikipedia:Mesoderm + Primary germ layer that is the middle of the embryonic germ layers.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000304 - AAO - AAO:EJS + AAO + AAO:EJS The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000152 - VHOG + VHOG + ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722 - http://bgee.unil.ch/ sponges do not seem to have a mesoderm and accordingly Amphimedon lacks transcription factors involved in mesoderm development (Fkh, Gsc, Twist, Snail)[http://www.nature.com/nature/journal/v466/n7307/full/nature09201.html]. Mesoderm may not be homologous across verteberates - https://github.com/obophenotype/uberon/wiki/The-neural-crest + @@ -239625,8 +53862,8 @@ The modern definition of neurosecretion has evolved to include the release of an entire mesoderm - SCTID:362854004 - https://orcid.org/0000-0002-6601-2165 + + @@ -239634,6 +53871,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -239660,6 +53898,8 @@ The modern definition of neurosecretion has evolved to include the release of an stomodeal This class groups together disparate structures as all being the anterior part of the early metazoan digestive tract and precursor of the mouth. However, the developmental processes vary, so this class may be split in future. E.g. in mammals it is a rostral depression surrounded by prominences. Outgrowth of the prominences produces a stomodeal cavity. stomodeal-hypophyseal primordium + + BTO:0004224 EHDAA2:0001929 EMAPA:16263 @@ -239669,7 +53909,6 @@ The modern definition of neurosecretion has evolved to include the release of an TAO:0001290 TGMA:0000135 UMLS:C1514977 - Wikipedia:Stomodeum XAO:0000269 ZFA:0001290 mouth primordium @@ -239686,24 +53925,24 @@ The modern definition of neurosecretion has evolved to include the release of an stomodeum - http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png + http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity. - Wikipedia:Stomodeum - http://orcid.org/0000-0002-6601-2165 - https://github.com/obophenotype/uberon/issues/326 + + + Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001290 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -239734,13 +53973,13 @@ The modern definition of neurosecretion has evolved to include the release of an primitive oral cavity - https://orcid.org/0000-0002-6601-2165 + stomatodeum - Wikipedia:Stomodeum + @@ -239767,6 +54006,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -239807,6 +54047,8 @@ The modern definition of neurosecretion has evolved to include the release of an + + AAO:0011087 EHDAA2:0000121 EMAPA:25038 @@ -239815,7 +54057,6 @@ The modern definition of neurosecretion has evolved to include the release of an TAO:0000066 UMLS:C0231054 VHOG:0000139 - Wikipedia:Proctodeum XAO:0001019 ZFA:0000066 embryonic proctodaeum @@ -239833,7 +54074,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -239844,32 +54085,32 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract. + + ZFA:0000066 - https://github.com/obophenotype/uberon/issues/685 - https://sourceforge.net/p/fbbtdv/tickets/52 An inward fold on the surface of the embryonic ectoderm that develops into part of the anal passage.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000066 - TAO - ZFIN:curator + TAO + ZFIN:curator Inward fold on the surface of the embryonic ectoderm that develops into part of the anal passage.[AAO] - 2012-06-20 + 2012-06-20 AAO:0011087 - AAO + AAO ZFA:0000066 @@ -240003,10 +54244,12 @@ The modern definition of neurosecretion has evolved to include the release of an - Portion of alimentary canal with increased circular and longitudinal smooth muscle. Bounded posteriorly by the pyloric sphincter. Mucosal lining has increased folding.[AAO] It appears that the stomach has an ancient origin. The stomach first appears in the fish lineage. The prevertebrate chordates do not have a true stomach, whereas the cartilaginous and bony fish do. Although most fish do have a true stomach, some fish species appear to have lost the stomach secondarily. The remaining vertebrate lineages do have a true stomach (at least in the adult animal), although there is great variation in the size and shape of the stomach.[well established][VHOG] We restrict this to the vertebrate specific structure - see the grouping class 'food storage organ' for analogous structures in other species. Teleosts: Zebrafish is functionally stomach-less, but may retain ontogenic footprint. Although the precise shape and size of the stomach varies widely among different vertebrates, the relative positions of the oesophageal and duodenal openings remain relatively constant. As a result, the organ always curves somewhat to the left before curving back to meet the pyloric sphincter. However, lampreys, hagfishes, chimaeras, lungfishes, and some teleost fish have no stomach at all, with the oesophagus opening directly into the intestine. The gastric lining is usually divided into two regions, an anterior portion lined by fundic glands, and a posterior with pyloric glands. Cardiac glands are unique to mammals, and even then are absent in a number of species. The distributions of these glands vary between species, and do not always correspond with the same regions as in man. Furthermore, in many non-human mammals, a portion of the stomach anterior to the cardiac glands is lined with epithelium essentially identical to that of the oesophagus. Ruminants, in particular, have a complex stomach, the first three chambers of which are all lined with oesophageal mucosa + + + AAO:0000579 ANISEED:1235297 BTO:0001307 @@ -240023,11 +54266,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D013270 MIAA:0000051 NCIT:C12391 - SCTID:181246003 + OpenCyc:Mx4rvVjlqpwpEbGdrcN5Y29ycA TAO:0002121 UMLS:C0038351 VHOG:0000408 - Wikipedia:Stomach XAO:0000128 galen:Stomach stomach chamber @@ -240038,26 +54280,25 @@ The modern definition of neurosecretion has evolved to include the release of an ventriculus UBERON:0000945 - stomach - https://upload.wikimedia.org/wikipedia/commons/e/e0/Stomach_diagram.svg + https://upload.wikimedia.org/wikipedia/commons/e/e0/Stomach_diagram.svg - cjm + cjm - cjm + cjm @@ -240068,7 +54309,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia @@ -240080,7 +54321,7 @@ The modern definition of neurosecretion has evolved to include the release of an absent in lampreys and hagfishes - ISBN:0073040584 + ISBN:0073040584 @@ -240097,52 +54338,52 @@ The modern definition of neurosecretion has evolved to include the release of an An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium. - ISBN:0073040584 - Wikipedia:Stomach - https://orcid.org/0000-0002-6601-2165 + + + ISBN:0073040584 - Wikipedia + Wikipedia - Wikipedia + Wikipedia - ZFA + ZFA - Wikipedia + Wikipedia Portion of alimentary canal with increased circular and longitudinal smooth muscle. Bounded posteriorly by the pyloric sphincter. Mucosal lining has increased folding.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000579 - AAO - AAO:EJS + AAO + AAO:EJS It appears that the stomach has an ancient origin. The stomach first appears in the fish lineage. The prevertebrate chordates do not have a true stomach, whereas the cartilaginous and bony fish do. Although most fish do have a true stomach, some fish species appear to have lost the stomach secondarily. The remaining vertebrate lineages do have a true stomach (at least in the adult animal), although there is great variation in the size and shape of the stomach.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000408 - VHOG + VHOG + DOI:10.1046/j.1525-142x.2000.00076.x Smith DM, Grasty RC, Theodosiou NA, Tabin CJ, Nascone-Yoder NM, Evolutionary relationships between the amphibian, avian, and mammalian stomachs. Evolution and development (2000) - http://bgee.unil.ch/ @@ -240166,7 +54407,7 @@ The modern definition of neurosecretion has evolved to include the release of an ventriculus - Wikipedia:Stomach + @@ -240209,6 +54450,9 @@ The modern definition of neurosecretion has evolved to include the release of an When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG] aortic All amniotes have a broadly similar arrangement to that of humans, albeit with a number of individual variations. In fish, however, there are two separate vessels referred to as aortas. The ventral aorta carries de-oxygenated blood from the heart to the gills; part of this vessel forms the ascending aorta in tetrapods (the remainder forms the pulmonary artery). A second, dorsal aorta carries oxygenated blood from the gills to the rest of the body, and is homologous with the descending aorta of tetrapods. The two aortas are connected by a number of vessels, one passing through each of the gills. Amphibians also retain the fifth connecting vessel, so that the aorta has two parallel arches + + + AAO:0010213 BTO:0000135 CALOHA:TS-0046 @@ -240222,10 +54466,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D001011 MIAA:0000035 NCIT:C12669 - SCTID:181298001 + OpenCyc:Mx4rvVjvTpwpEbGdrcN5Y29ycA UMLS:C0003483 VHOG:0001523 - Wikipedia:Aorta XAO:0003010 galen:Aorta trunk of aortic tree @@ -240240,15 +54483,13 @@ The modern definition of neurosecretion has evolved to include the release of an aorta - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb - https://upload.wikimedia.org/wikipedia/commons/9/91/Aorta_scheme.jpg + https://upload.wikimedia.org/wikipedia/commons/9/91/Aorta_scheme.jpg - MA + MA @@ -240259,7 +54500,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -240276,36 +54517,36 @@ The modern definition of neurosecretion has evolved to include the release of an The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation. - ISBN:0-683-40008-8 + + + ISBN:0-683-40008-8 MESH:A07.231.114.056 MP:0000272 - Wikipedia:Aorta - http://orcid.org/0000-0002-6601-2165 This class is currently a mixed bag, encompassing (1) the entirety of the mammalian aorta together with (2) the developmental and phylogenetic homologs of its segments: the ventral aorta and dorsal aortae. - WP + WP The main artery of the circulatory system which carries oxygenated blood from the heart to all the arteries of the body except those of the lungs.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010213 - AAO - AAO:BJB + AAO + AAO:BJB When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001523 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 - http://bgee.unil.ch/ @@ -240317,7 +54558,7 @@ The modern definition of neurosecretion has evolved to include the release of an dorsal aorta - Wikipedia:Aorta#In_other_animals + ZFA:0000014 @@ -240325,7 +54566,7 @@ The modern definition of neurosecretion has evolved to include the release of an arteria maxima - Wikipedia:Aorta + @@ -240426,6 +54667,9 @@ The modern definition of neurosecretion has evolved to include the release of an relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO] As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[well established][VHOG] cardiac + + + AAO:0010210 BILA:0000020 BTO:0000562 @@ -240442,11 +54686,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D006321 MIAA:0000036 NCIT:C12727 - SCTID:302509004 + OpenCyc:Mx4rvVjvDpwpEbGdrcN5Y29ycA TAO:0000114 UMLS:C0018787 VHOG:0000276 - Wikipedia:Heart XAO:0000064 ZFA:0000114 galen:Heart @@ -240465,9 +54708,6 @@ The modern definition of neurosecretion has evolved to include the release of an Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706 heart - https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Heart.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb @@ -240478,7 +54718,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -240489,50 +54729,50 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/The-neural-crest + A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ. - Wikipedia:Heart - http://orcid.org/0000-0002-6601-2165 + + Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000114 - TAO - ZFIN:curator + TAO + ZFIN:curator Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010210 - AAO - AAO:BJB + AAO + AAO:BJB relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO] - 2012-06-20 + 2012-06-20 AAO:0010210 - AAO + AAO As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000276 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481 - http://bgee.unil.ch/ @@ -240544,7 +54784,7 @@ The modern definition of neurosecretion has evolved to include the release of an chambered heart - https://orcid.org/0000-0002-6601-2165 + @@ -240564,13 +54804,30 @@ The modern definition of neurosecretion has evolved to include the release of an - + + + + + + + + + + + + + + + + + + @@ -240602,6 +54859,9 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system containing glands which regulates bodily functions though the secretion of hormones.[AAO] Multicellular organisms have complex endocrine systems, allowing responses to environmental stimuli, regulation of development, reproduction, and homeostasis. Nuclear receptors (NRs), a metazoan-specific family of ligand-activated transcription factors, play central roles in endocrine responses, as intermediates between signaling molecules and target genes. The NR family includes ligand-bound and orphan receptors, that is, receptors with no known ligand or for which there is no ligand Pocket. Understanding NR evolution has been further improved by comparison of several completed genomes, particularly those of deuterostomes and ecdysozoans. In contrast, evolution of NR ligands is still much debated. One hypothesis proposes that several independent gains and losses of ligand-binding ability in NRs occurred in protostomes and deuterostomes. A second hypothesis, pertaining to the NR3 subfamily (vertebrate steroid hormone receptors and estrogen related receptor), proposes that before the divergence of protostomes and deuterostomes, there was an ancestral steroid receptor (AncSR) that was ligand-activated and that orphan receptors secondarily lost the ability to bind a ligand. (...) Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages (...).[well established][VHOG] endocrine + + + AAO:0010279 CALOHA:TS-1301 EFO:0002969 @@ -240614,11 +54874,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000012 MESH:D004703 NCIT:C12705 - SCTID:278876000 TAO:0001158 UMLS:C0014136 VHOG:0000098 - Wikipedia:Endocrine_system XAO:0000158 ZFA:0001158 endocrine glandular system @@ -240636,27 +54894,27 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity. + NLM:endocrine+system - Wikipedia:Endocrine_system Anatomical system containing glands which regulates bodily functions though the secretion of hormones.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010279 - AAO - AAO:BJB + AAO + AAO:BJB Multicellular organisms have complex endocrine systems, allowing responses to environmental stimuli, regulation of development, reproduction, and homeostasis. Nuclear receptors (NRs), a metazoan-specific family of ligand-activated transcription factors, play central roles in endocrine responses, as intermediates between signaling molecules and target genes. The NR family includes ligand-bound and orphan receptors, that is, receptors with no known ligand or for which there is no ligand Pocket. Understanding NR evolution has been further improved by comparison of several completed genomes, particularly those of deuterostomes and ecdysozoans. In contrast, evolution of NR ligands is still much debated. One hypothesis proposes that several independent gains and losses of ligand-binding ability in NRs occurred in protostomes and deuterostomes. A second hypothesis, pertaining to the NR3 subfamily (vertebrate steroid hormone receptors and estrogen related receptor), proposes that before the divergence of protostomes and deuterostomes, there was an ancestral steroid receptor (AncSR) that was ligand-activated and that orphan receptors secondarily lost the ability to bind a ligand. (...) Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000098 - VHOG + VHOG + DOI:10.1073/pnas.0812138106 Markov GV, Tavares R, Dauphin-Villemant C, Demeneix BA, Baker ME, Laudet V, Independent elaboration of steroid hormone signaling pathways in metazoans. PNAS (2009) - http://bgee.unil.ch/ @@ -240728,6 +54986,10 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO) (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG] + + + + AAO:0010478 ABA:Brain BAMS:Br @@ -240754,13 +55016,12 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D001921 MIAA:0000098 NCIT:C12439 + OpenCyc:Mx4rvVjT65wpEbGdrcN5Y29ycA PBA:3999 - SCTID:258335003 TAO:0000008 UMLS:C0006104 UMLS:C1269537 VHOG:0000157 - Wikipedia:Brain XAO:0000010 ZFA:0000008 galen:Brain @@ -240780,14 +55041,12 @@ The modern definition of neurosecretion has evolved to include the release of an brain - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb - GO + GO @@ -240798,7 +55057,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -240809,54 +55068,59 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. - Wikipedia:Brain - https://github.com/obophenotype/uberon/issues/300 + + Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000008 - TAO - ZFIN:curator + TAO + ZFIN:curator Part of the central nervous system situated within the cranium and composed of both nerve cell bodies and nerve fibers.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010478 - AAO - AAO:BJB + AAO + AAO:BJB The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO) - http://neurolex.org/wiki/Cumbo_terms + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000157 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.165 - http://bgee.unil.ch/ UMLS:C0006104 BIRNLEX:796 + + + + + UMLS:C0006104 ncithesaurus:Brain @@ -240922,7 +55186,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any thin layer or plate. TODO - merge with cell layer? laminar - Wikipedia:Lamina_of_the_vertebral_arch + laminar tissue uberon UBERON:0000957 @@ -240930,13 +55194,13 @@ The modern definition of neurosecretion has evolved to include the release of an lamina - http://upload.wikimedia.org/wikipedia/commons/8/80/Laminaarcusvertebrae.png + http://upload.wikimedia.org/wikipedia/commons/8/80/Laminaarcusvertebrae.png Any thin layer or plate. - Wikipedia:Lamina_of_the_vertebral_arch + @@ -240963,13 +55227,14 @@ The modern definition of neurosecretion has evolved to include the release of an The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted]. + + + BAMS:cern FMA:5859 NCIT:C32299 NLXANAT:20090207 - SCTID:360497008 UMLS:C0228815 - Wikipedia:Cervical_nerves neuronames:2351 cervical nerve cervical nerve tree @@ -240980,13 +55245,13 @@ The modern definition of neurosecretion has evolved to include the release of an Innervates: sternohyoid muscle, sternothyroid muscle, omohyoid muscle[WP] nerve of cervical vertebra - http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray795.png + http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray795.png The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted]. - Wikipedia:Cervical_nerves + @@ -241005,7 +55270,7 @@ The modern definition of neurosecretion has evolved to include the release of an nervus cervicalis FMA:5859 - FMA:TA + FMA:TA @@ -241046,7 +55311,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -241119,6 +55383,9 @@ The modern definition of neurosecretion has evolved to include the release of an corneal Compared to terrestial animals, the cornea of zebrafish is relatively flat. It consists of nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals. In fish, and aquatic vertebrates in general, the cornea plays no role in focusing light, since it has virtually the same refractive index as water + + + AAO:0010344 BTO:0000286 CALOHA:TS-0171 @@ -241132,11 +55399,10 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000266 MESH:D003315 NCIT:C12342 - SCTID:181162001 + OpenCyc:Mx4rvViBa5wpEbGdrcN5Y29ycA TAO:0000640 UMLS:C0010031 VHOG:0000164 - Wikipedia:Cornea XAO:0000180 ZFA:0000640 cornea of camera-type eye @@ -241150,7 +55416,7 @@ The modern definition of neurosecretion has evolved to include the release of an cornea - http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg + http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg @@ -241161,7 +55427,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -241172,7 +55438,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -241194,13 +55460,13 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MESH:A09.371.060.217 MP:0001312 @@ -241221,7 +55487,7 @@ The modern definition of neurosecretion has evolved to include the release of an corneas ZFA:0000640 - + @@ -241261,11 +55527,14 @@ The modern definition of neurosecretion has evolved to include the release of an - A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina. + Transparent part of camera-type eye that helps to refract light to be focused on the retina. The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] This class excludes compound eye corneal lenses. + + + AAO:0010348 BTO:0000723 CALOHA:TS-0545 @@ -241278,12 +55547,11 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D007908 MIAA:0000141 NCIT:C12743 + OpenCyc:Mx4rvVj0fZwpEbGdrcN5Y29ycA RETIRED_EHDAA2:0000975 - SCTID:181169005 TAO:0000035 UMLS:C0023317 VHOG:0000169 - Wikipedia:Lens_(anatomy) XAO:0000008 ZFA:0000035 camera-type eye lens @@ -241299,25 +55567,25 @@ The modern definition of neurosecretion has evolved to include the release of an - The lens is avascular and nourished by diffusion from the aqueous and vitreous humors. + The lens is avascular and nourished by diffusion from the aqueous and vitreous lens of camera-type eye - A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina. - Wikipedia:Lens_(anatomy) - http://orcid.org/0000-0002-6601-2165 + Transparent part of camera-type eye that helps to refract light to be focused on the retina. + + The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000169 - VHOG + VHOG + DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007) - http://bgee.unil.ch/ @@ -241347,21 +55615,20 @@ The modern definition of neurosecretion has evolved to include the release of an lens crystallina - Wikipedia:Lens_(anatomy) + crystalline lens BTO:0000723 - PMID:36055924 lenses ZFA:0000035 - + @@ -241435,6 +55702,10 @@ The modern definition of neurosecretion has evolved to include the release of an The portion of the eye developing from the optic primordium and including the neural retina and the retinal pigment layer. Kimmel et al, 1995.[TAO] The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] retinal + + + + AAO:0010352 BAMS:R BIRNLEX:1153 @@ -241454,12 +55725,11 @@ The modern definition of neurosecretion has evolved to include the release of an MIAA:0000142 NCIT:C12343 NIFSTD_RETIRED:birnlex_1156 - SCTID:181171005 + OpenCyc:Mx4rvViTfpwpEbGdrcN5Y29ycA TAO:0000152 UMLS:C0035298 UMLS:C1278894 VHOG:0000229 - Wikipedia:Retina XAO:0000009 ZFA:0000152 neuronames:1862 @@ -241477,7 +55747,7 @@ The modern definition of neurosecretion has evolved to include the release of an Currently this class encompasses only verteberate AOs but could in theory also include cephalopod - we may want to make a more specific class for vertebrate retina. note that this class excludes ommatidial retinas, as the retina must be part of an eyeball. Use the parent class photoreceptor array / light-sensitive tissue for arthropods retina - http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png + http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png @@ -241488,7 +55758,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -241499,7 +55769,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -241510,7 +55780,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -241521,39 +55791,44 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. - Wikipedia:Retina - ZFIN:curator + + ZFIN:curator The portion of the eye developing from the optic primordium and including the neural retina and the retinal pigment layer. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000152 - TAO - ZFIN:curator + TAO + ZFIN:curator The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000229 - VHOG + VHOG + DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007) - http://bgee.unil.ch/ UMLS:C0035298 BIRNLEX:1153 + + + + + UMLS:C0035298 ncithesaurus:Retina @@ -241579,7 +55854,7 @@ The modern definition of neurosecretion has evolved to include the release of an retinas ZFA:0000152 - + @@ -241618,6 +55893,7 @@ The modern definition of neurosecretion has evolved to include the release of an ocular optic Note that whilst this is classified as an organ, it is in fact more of a unit composed of different structures: in Drosophila, it includes the interommatidial bristle as a part; we consider here the vertebrate eye to include the eyeball/eye proper as a part, with the eye having as parts (when present): eyelids, conjuctiva, + BILA:0000017 BTO:0000439 CALOHA:TS-0309 @@ -241628,7 +55904,7 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000140 MESH:D005123 MIAA:0000140 - Wikipedia:Eye + OpenCyc:Mx4rvViTvpwpEbGdrcN5Y29ycA uberon light-detecting organ visual apparatus @@ -241650,7 +55926,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:21062451 + @@ -241661,13 +55937,13 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:21062451 + An organ that detects light. - https://orcid.org/0000-0002-6601-2165 + @@ -241691,12 +55967,12 @@ The modern definition of neurosecretion has evolved to include the release of an The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells. ommatidial + BTO:0001922 FBbt:00004510 HAO:0000666 MAT:0000143 MIAA:0000143 - Wikipedia:Ommatidium omatidium uberon omatidia @@ -241708,19 +55984,19 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:21062451 + The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells. - PMID:21062451 + omatidia - + @@ -241741,6 +56017,18 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + @@ -241757,6 +56045,9 @@ The modern definition of neurosecretion has evolved to include the release of an true necks are considered to be present when the pectoral girdle is separate from the skull - Tiktaalik is the earliest known fish to have a true neck. cervical + + + AEO:0000108 BTO:0000420 CALOHA:TS-2045 @@ -241770,9 +56061,8 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D009333 MIAA:0000297 NCIT:C13063 - SCTID:302550007 + OpenCyc:Mx4rvVjLF5wpEbGdrcN5Y29ycA UMLS:C0027530 - Wikipedia:Neck galen:Neck uberon collum @@ -241782,13 +56072,13 @@ The modern definition of neurosecretion has evolved to include the release of an neck - https://upload.wikimedia.org/wikipedia/commons/9/99/Female_neck.jpg + https://upload.wikimedia.org/wikipedia/commons/9/99/Female_neck.jpg An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column. - http://orcid.org/0000-0002-6601-2165 + @@ -241806,7 +56096,7 @@ The modern definition of neurosecretion has evolved to include the release of an collum - Wikipedia:Neck + @@ -241895,6 +56185,9 @@ The modern definition of neurosecretion has evolved to include the release of an The serous membrane that covers the lungs and lines the pleural cavity. [Kaufman_MH_and_Bard_JBL, The_anatomical_basis_of_mouse_development_(1999)_San_Diego:_Academic_Press, p.264][VHOG] pleural In MA, is_a cavity lining (which we equate to parietal). In FMA, is_a (viscous) serous membrane (which includes mesothelium plus connective tissue). Note the MA structure should probably be associated with the mesothelium of pleura in FMA. JB/EHDAA2 argues the term 'pleura' is best used for the mesothelial lining (thus excluding connective tissue). See https://github.com/obophenotype/uberon/issues/86 + + + BTO:0001791 CALOHA:TS-2081 EFO:0001980 @@ -241905,10 +56198,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000433 MESH:D010994 NCIT:C12469 - SCTID:181609007 + OpenCyc:Mx4rv3zwLZwpEbGdrcN5Y29ycA UMLS:C0032225 VHOG:0000394 - Wikipedia:Pleura wall of pleural sac uberon pleura @@ -241918,7 +56210,7 @@ The modern definition of neurosecretion has evolved to include the release of an pleura - http://upload.wikimedia.org/wikipedia/commons/a/ab/Gray965.png + http://upload.wikimedia.org/wikipedia/commons/a/ab/Gray965.png @@ -241929,34 +56221,34 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/issues/86 + The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion). - ISBN:0-683-40008-8 + + + ISBN:0-683-40008-8 MP:0010820 - UBERON:cjm - Wikipedia:Pulmonary_pleurae - https://github.com/obophenotype/uberon/issues/1231 + UBERON:cjm + ISBN:978-0030223693 - https://orcid.org/0000-0003-3308-6245 The serous membrane that covers the lungs and lines the pleural cavity. [Kaufman_MH_and_Bard_JBL, The_anatomical_basis_of_mouse_development_(1999)_San_Diego:_Academic_Press, p.264][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000394 - VHOG + VHOG + ISBN:0124020607 - http://bgee.unil.ch/ @@ -242005,11 +56297,14 @@ The modern definition of neurosecretion has evolved to include the release of an - Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]. + Anatomical cluster that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]. Anatomical cluster that consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[VSAO] Anatomical cluster which consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[TAO] articulation joint + + + AEO:0000182 BTO:0001686 CALOHA:TS-2023 @@ -242022,13 +56317,12 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D007596 MIAA:0000188 NCIT:C13044 + OpenCyc:Mx4rvVjjdpwpEbGdrcN5Y29ycA RETIRED_EHDAA2:0003182 - SCTID:302536002 TAO:0000367 UMLS:C0022417 VHOG:0001276 VSAO:0000101 - Wikipedia:Joint XAO:0000171 ZFA:0001596 galen:Joint @@ -242046,28 +56340,28 @@ The modern definition of neurosecretion has evolved to include the release of an - Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]. - GO_REF:0000034 + Anatomical cluster that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]. + + + GO_REF:0000034 VSAO:0000101 - Wikipedia:Joint - http://dx.plos.org/10.1371/journal.pone.0051070 Anatomical cluster that consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000101 - VSAO - PSPUB:0000170 + VSAO + PSPUB:0000170 Anatomical cluster which consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000367 - TAO + TAO TAO:pem @@ -242100,7 +56394,7 @@ The modern definition of neurosecretion has evolved to include the release of an joints ZFA:0001596 - + @@ -242109,6 +56403,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -242145,6 +56440,10 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum. [TFD][VHOG] During the embryonic development of birds and mammals, neuroblasts migrate from the cerebellum into the ventral part of the rhombencephalon and differentiate into pontine and other nuclei, which relay information from between the cerebrum and cerebellum, and a conspicuous band of transverse fibers. This region is known as the pons. A pons does not differentiate in reptiles and anamniotes (...).[well established][VHOG] + + + + BAMS:PONS BAMS:Pons BIRNLEX:733 @@ -242165,11 +56464,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D011149 MIAA:0000115 NCIT:C12511 - SCTID:279103004 UMLS:C0032639 UMLS:C1280999 VHOG:0001176 - Wikipedia:Pons neuronames:547 pons Varolii pons of Varolius @@ -242181,7 +56478,7 @@ The modern definition of neurosecretion has evolved to include the release of an pons - http://upload.wikimedia.org/wikipedia/commons/3/36/Gray768.png + http://upload.wikimedia.org/wikipedia/commons/3/36/Gray768.png @@ -242204,27 +56501,32 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001176 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/pons + VHOG + + During the embryonic development of birds and mammals, neuroblasts migrate from the cerebellum into the ventral part of the rhombencephalon and differentiate into pontine and other nuclei, which relay information from between the cerebrum and cerebellum, and a conspicuous band of transverse fibers. This region is known as the pons. A pons does not differentiate in reptiles and anamniotes (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001176 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.474 - http://bgee.unil.ch/ UMLS:C0032639 BIRNLEX:733 + + + + + UMLS:C0032639 ncithesaurus:Pons_Varolii @@ -242270,6 +56572,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -242308,6 +56611,9 @@ The modern definition of neurosecretion has evolved to include the release of an Arguably, one of the most important aspects of urbilaterian organogenesis would have been gonadogenesis, since Urbilateria must have successfully generated gametes and developed a strategy for extrusion and fertilization, in order to be the ancestor of all living Bilateria.[well established][VHOG] 2022-06-10T18:22:34Z + + + AAO:0010258 BILA:0000103 BTO:0000081 @@ -242325,12 +56631,11 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000326 MIAA:0000305 NCIT:C12841 - SCTID:278875001 + OpenCyc:Mx4rvVja4ZwpEbGdrcN5Y29ycA TAO:0000632 UMLS:C1261210 VHOG:0000182 WBbt:0005747 - Wikipedia:Reproductive_system XAO:0000142 ZFA:0000632 genital system @@ -242350,32 +56655,32 @@ The modern definition of neurosecretion has evolved to include the release of an reproductive system - http://upload.wikimedia.org/wikipedia/commons/5/52/Penis.svg + http://upload.wikimedia.org/wikipedia/commons/5/52/Penis.svg Anatomical system that has as its parts the organs concerned with reproduction. - Wikipedia:Reproductive_system + Anatomical system which consists of organs and tissues associated with sexual reproduction of the organism.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010258 - AAO - AAO:BJB + AAO + AAO:BJB Arguably, one of the most important aspects of urbilaterian organogenesis would have been gonadogenesis, since Urbilateria must have successfully generated gametes and developed a strategy for extrusion and fertilization, in order to be the ancestor of all living Bilateria.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000182 - VHOG + VHOG + PMID:21672850 Extavour CGM, Gray anatomy: phylogenetic patterns of somatic gonad structures and reproductive strategies across Bilateria. Integrative and Comparative Biology (2007) - http://bgee.unil.ch/ @@ -242387,7 +56692,7 @@ The modern definition of neurosecretion has evolved to include the release of an genitalia - + @@ -242417,7 +56722,7 @@ The modern definition of neurosecretion has evolved to include the release of an systemata genitalia - Wikipedia:Reproductive_system + @@ -242437,6 +56742,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -242468,6 +56774,9 @@ The modern definition of neurosecretion has evolved to include the release of an Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved.[uncertain][VHOG] gonadal FMA xref is a 'general anatomical term' + + + AAO:0000213 BILA:0000123 BSA:0000079 @@ -242480,12 +56789,11 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002420 MESH:D006066 NCIT:C12725 - SCTID:304623008 + OpenCyc:Mx4rwQvdiZwpEbGdrcN5Y29ycA TAO:0000413 UMLS:C0018067 VHOG:0000397 WBbt:0005175 - Wikipedia:Gonad XAO:0003146 ZFA:0000413 gonada @@ -242503,44 +56811,44 @@ The modern definition of neurosecretion has evolved to include the release of an Reproductive organ that produces and releases eggs (ovary) or sperm (testis). + ISBN:0140512888 - Wikipedia:Gonad ZFA:0000413 - ZFIN:curator + ZFIN:curator Anatomical structure which produces gametes as well as certain sex hormones controlled by the pituitary gonadotropins.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000213 - AAO - AAO:BJB + AAO + AAO:BJB The part of the reproductive system that produces and releases eggs (ovary) or sperm (testis).[TAO] - 2012-08-14 + 2012-08-14 TAO:0000413 - TAO - ZFIN:curator + TAO + ZFIN:curator Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000397 - VHOG + VHOG + DOI:10.1146/annurev.cellbio.042308.13350 DeFalco T, Capel B, Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annual review of cell and developmental biology (2009) - http://bgee.unil.ch/ FMA xref is a 'general anatomical term' - FMA + FMA @@ -242553,7 +56861,7 @@ The modern definition of neurosecretion has evolved to include the release of an gonads ZFA:0000413 - + @@ -242600,6 +56908,9 @@ The modern definition of neurosecretion has evolved to include the release of an (...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG] ovarian Ovaries of some kind are found in the female reproductive system of many animals that employ sexual reproduction, including invertebrates. However, they develop in a very different way in most invertebrates than they do in vertebrates, and are not truly homologous. Many of the features found in human ovaries are common to all vertebrates, including the presence of follicular cells, tunica albuginea, and so on. However, many species produce a far greater number of eggs during their lifetime than do humans, so that, in fish and amphibians, there may be hundreds, or even millions of fertile eggs present in the ovary at any given time. In these species, fresh eggs may be developing from the germinal epithelium throughout life. Corpora lutea are found only in mammals, and in some elasmobranch fish; in other species, the remnants of the follicle are quickly resorbed by the ovary. In birds, reptiles, and monotremes, the egg is relatively large, filling the follicle, and distorting the shape of the ovary at maturity. Amphibians and reptiles have no ovarian medulla; the central part of the ovary is a hollow, lymph-filled space. The ovary of teleosts is also often hollow, but in this case, the eggs are shed into the cavity, which opens into the oviduct. Although most normal female vertebrates have two ovaries, this is not the case in all species. In birds and platypuses, the right ovary never matures, so that only the left is functional. In some elasmobranchs, the reverse is true, with only the right ovary fully developing. In the primitive jawless fish, and some teleosts, there is only one ovary, formed by the fusion of the paired organs in the embryo + + + AAO:0000371 BILA:0000125 BSA:0000080 @@ -242617,11 +56928,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D010053 MIAA:0000125 NCIT:C12404 - SCTID:181464007 + OpenCyc:Mx4rvVi9QJwpEbGdrcN5Y29ycA TAO:0000403 UMLS:C0029939 VHOG:0000251 - Wikipedia:Ovary XAO:0000258 ZFA:0000403 animal ovary @@ -242658,50 +56968,50 @@ The modern definition of neurosecretion has evolved to include the release of an ovary - http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png - https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png + http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png + https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png The gonad of a female organism which contains germ cells. - ISBN:0-683-40008-8 + + ISBN:0-683-40008-8 MP:0001126 - Wikipedia:Ovary Either of paired female reproductive organs involved in production of ova and female sex hormones.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000371 - AAO - AAO:BJB + AAO + AAO:BJB Female reproductive organ.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000403 - TAO - ZFIN:curator + TAO + ZFIN:curator (...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000251 - VHOG + VHOG + DOI:10.1093/icb/icm052 Extavour CGM, Gray anatomy: phylogenetic patterns of somatic gonad structures and reproductive strategies across the Bilateria. Integrative and Comparative Biology (2007), DOI:10.1146/annurev.cellbio.042308.13350 DeFalco T and Capel B, Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annual review of cell and developmental biology (2009) - http://bgee.unil.ch/ Ovaries of some kind are found in the female reproductive system of many animals that employ sexual reproduction, including invertebrates. However, they develop in a very different way in most invertebrates than they do in vertebrates, and are not truly homologous. Many of the features found in human ovaries are common to all vertebrates, including the presence of follicular cells, tunica albuginea, and so on. However, many species produce a far greater number of eggs during their lifetime than do humans, so that, in fish and amphibians, there may be hundreds, or even millions of fertile eggs present in the ovary at any given time. In these species, fresh eggs may be developing from the germinal epithelium throughout life. Corpora lutea are found only in mammals, and in some elasmobranch fish; in other species, the remnants of the follicle are quickly resorbed by the ovary. In birds, reptiles, and monotremes, the egg is relatively large, filling the follicle, and distorting the shape of the ovary at maturity. Amphibians and reptiles have no ovarian medulla; the central part of the ovary is a hollow, lymph-filled space. The ovary of teleosts is also often hollow, but in this case, the eggs are shed into the cavity, which opens into the oviduct. Although most normal female vertebrates have two ovaries, this is not the case in all species. In birds and platypuses, the right ovary never matures, so that only the left is functional. In some elasmobranchs, the reverse is true, with only the right ovary fully developing. In the primitive jawless fish, and some teleosts, there is only one ovary, formed by the fusion of the paired organs in the embryo - WP + WP @@ -242719,109 +57029,109 @@ The modern definition of neurosecretion has evolved to include the release of an female organism genitalia gonad - OBOL:automatic + OBOL:automatic female organism genitalia gonada - OBOL:automatic + OBOL:automatic female organism reproductive system gonad - OBOL:automatic + OBOL:automatic female organism reproductive system gonada - OBOL:automatic + OBOL:automatic female reproductive system gonad - OBOL:automatic + OBOL:automatic female reproductive system gonada - OBOL:automatic + OBOL:automatic genitalia of female organism gonad - OBOL:automatic + OBOL:automatic genitalia of female organism gonada - OBOL:automatic + OBOL:automatic gonad of female organism genitalia - OBOL:automatic + OBOL:automatic gonad of female organism reproductive system - OBOL:automatic + OBOL:automatic gonad of female reproductive system - OBOL:automatic + OBOL:automatic gonad of genitalia of female organism - OBOL:automatic + OBOL:automatic gonad of reproductive system of female organism - OBOL:automatic + OBOL:automatic gonada of female organism genitalia - OBOL:automatic + OBOL:automatic gonada of female organism reproductive system - OBOL:automatic + OBOL:automatic gonada of female reproductive system - OBOL:automatic + OBOL:automatic gonada of genitalia of female organism - OBOL:automatic + OBOL:automatic gonada of reproductive system of female organism - OBOL:automatic + OBOL:automatic @@ -242834,25 +57144,25 @@ The modern definition of neurosecretion has evolved to include the release of an reproductive system of female organism gonad - OBOL:automatic + OBOL:automatic reproductive system of female organism gonada - OBOL:automatic + OBOL:automatic ovaries - + ovarium - Wikipedia:Ovary + @@ -242902,6 +57212,9 @@ The modern definition of neurosecretion has evolved to include the release of an Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. In terrestrial vertebrates the epidermis often forms an outer keratinized or cornified layer, the stratum corneum. Interaction between the epideris and dermis gives rise to feathers (birds), hair and mammary glands (mammals), teeth and scales (placoid: chondrichthyans; cosmoids, ganoid, cycloid in bony fishes). epidermis skin + + + AAO:0000143 BTO:0000404 CALOHA:TS-0283 @@ -242915,11 +57228,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D004817 MIAA:0000154 NCIT:C12708 - SCTID:361694003 TAO:0000105 UMLS:C0014520 VHOG:0000077 - Wikipedia:Epidermis_(skin) XAO:0000028 ZFA:0000105 vertebrate epidermis @@ -242936,44 +57247,44 @@ The modern definition of neurosecretion has evolved to include the release of an The outer epithelial layer of the skin that is superficial to the dermis. - ISBN:0073040584 - http://orcid.org/0000-0002-6601-2165 + + ISBN:0073040584 A cellular, multilayered epithelium derived from the ectoderm. Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. Le Guellec et al, 2004.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000105 - TAO - ZFIN:curator + TAO + ZFIN:curator The outer epithelial layer of the external integument of the body that is derived from the embryonic epiblast.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000143 - AAO - AAO:BJB + AAO + AAO:BJB relationship loss: subclass external integument structures (AAO:0000961)[AAO] - 2012-06-20 + 2012-06-20 AAO:0000143 - AAO + AAO (...) outer epithelia in all metazoan animals are homologous. (...) The ancestor of all metazoans likely had an epidermis with a basal extracellular matrix (ECM), an apical extracellular glycocalyx, and one cilium with a striated rootlet per cell.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000077 - VHOG + VHOG + ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.71-72 - http://bgee.unil.ch/ @@ -243057,6 +57368,9 @@ The modern definition of neurosecretion has evolved to include the release of an The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO] There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG] + + + AAO:0000541 BTO:0000203 CALOHA:TS-1319 @@ -243072,11 +57386,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D012137 MIAA:0000030 NCIT:C12779 - SCTID:278197002 + OpenCyc:Mx4rvVjzFJwpEbGdrcN5Y29ycA TAO:0000272 UMLS:C0035237 VHOG:0000202 - Wikipedia:Respiratory_system XAO:0000117 ZFA:0000272 apparatus respiratorius @@ -243093,44 +57406,39 @@ The modern definition of neurosecretion has evolved to include the release of an respiratory system - http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg - https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Lung.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-lung.glb + http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg Functional system which consists of structures involved in respiration. - Wikipedia:Respiratory_system - http://orcid.org/0000-0002-6601-2165 + + - Wikipedia:Acoelomorpha + The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000541 - AAO - AAO:BJB + AAO + AAO:BJB There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000202 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.599 and Figure 18-23 - http://bgee.unil.ch/ @@ -243154,7 +57462,7 @@ The modern definition of neurosecretion has evolved to include the release of an systema respiratorium - Wikipedia:Respiratory_system + @@ -243181,9 +57489,9 @@ The modern definition of neurosecretion has evolved to include the release of an This class generically groups trachea and analagous structures throughout metazoa. Consider renaming, as the term could be taken to mean lumen of tracheal system (e.g. in SNOMED). As a grouping class this is quite vague, as it is not clear where the airway begins and ends airway airways + + FMA:265130 - SCTID:361380005 - Wikipedia:Trachea uberon UBERON:0001005 @@ -243194,20 +57502,20 @@ The modern definition of neurosecretion has evolved to include the release of an An airway through which respiratory air passes in organisms. - Wikipedia:Trachea + airway - http://orcid.org/0000-0002-6601-2165 + airways - http://orcid.org/0000-0002-6601-2165 - + + @@ -243252,10 +57560,11 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes. - An anatomical system consisting of the alimentary canal and digestive glands responsible for intake, absorption, digestion and excretion of food.[AAO] digestive many anatomy ontologies consider gastrointestinal system synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class + + AAO:0000129 BILA:0000082 BTO:0000058 @@ -243269,11 +57578,9 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000018 MESH:D004064 MIAA:0000018 - SCTID:278859004 TADS:0000170 TAO:0000339 WBbt:0005748 - Wikipedia:Digestive_system XAO:0000125 ZFA:0000339 galen:DigestiveSystem @@ -243285,7 +57592,6 @@ The modern definition of neurosecretion has evolved to include the release of an gut UBERON:0001007 - @@ -243295,24 +57601,24 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes. + FB:gg NLM:alimentary+system - Wikipedia:Digestive_system An anatomical system consisting of the alimentary canal and digestive glands responsible for intake, absorption, digestion and excretion of food.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000129 - AAO - AAO:BJB + AAO + AAO:BJB many anatomy ontologies consider gastrointestinal system synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class - MA + MA @@ -243383,14 +57689,17 @@ The modern definition of neurosecretion has evolved to include the release of an The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. + In various sources such as Encyclopedia Britannica, the excretory and urinary systems are indeed the same system (see wikipedia talk page); we merge two BTO classes here - An anatomical system which consists of organs and tissues which produce, store, and excrete urine.[AAO] Evolution of vertebrate renal anatomy appears quite conservative when compared, for example, to evolution of respiratory and cardiovascular systems in vertebrates. Major anatomical changes in vertebrates kidneys separate those of birds and mammals from kidneys of lower vertebrates. General increase in animal size from fish to mammals is reflected by an increase in total number of nephrons per kidney, rather than by constant change in tubular dimensions.[well established][VHOG] In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels This definition is inclusive of the organs of the vertebrate renal system, as well as the Malpighian tubules of insects, and allows for future incorporation of structures such as the antennal glands of crustaceans excretory system + + + AAO:0010257 BILA:0000015 BTO:0001244 @@ -243409,13 +57718,11 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D014551 MIAA:0000027 NCIT:C12413 - SCTID:362204003 TADS:0000162 TAO:0000163 UMLS:C1508753 VHOG:0000723 WBbt:0005736 - Wikipedia:Excretory_system XAO:0000143 ZFA:0000163 galen:UrinaryTract @@ -243428,62 +57735,60 @@ The modern definition of neurosecretion has evolved to include the release of an renal/urinary system UBERON:0001008 - - EDITOR_NOTE In various sources such as Encyclopedia Britannica, the excretory and urinary systems are indeed the same system (see wikipedia talk page); we merge two BTO classes here renal system The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. - DOI:10.1371/journal.pone.0099864 + GO:0072001 - Wikipedia + Wikipedia - Wikipedia:Acoelomorpha + An anatomical system which consists of organs and tissues which produce, store, and excrete urine.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010257 - AAO - AAO:BJB + AAO + AAO:BJB Evolution of vertebrate renal anatomy appears quite conservative when compared, for example, to evolution of respiratory and cardiovascular systems in vertebrates. Major anatomical changes in vertebrates kidneys separate those of birds and mammals from kidneys of lower vertebrates. General increase in animal size from fish to mammals is reflected by an increase in total number of nephrons per kidney, rather than by constant change in tubular dimensions.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000723 - VHOG + VHOG + ISBN:978-3540428541 Kapoor BG, Bhavna Khanna, Ichthyology Handbook (2004) p.406 - http://bgee.unil.ch/ In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels - GO + GO This definition is inclusive of the organs of the vertebrate renal system, as well as the Malpighian tubules of insects, and allows for future incorporation of structures such as the antennal glands of crustaceans - DOI:10.1371/journal.pone.0099864 + @@ -243599,32 +57904,31 @@ The modern definition of neurosecretion has evolved to include the release of an - Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO] We should divest ourselves of the view that earlier vertebrate groups were 'on their way' to becoming mammals, as clearly they were not such visionaries. Neither were their systems 'imperfect' as earlier anatomists thought. Instead, their circulatory systems served them well to address the ecological demands arising from their lifestyles.[well established][VHOG] + AAO:0000959 CALOHA:TS-2103 + OpenCyc:Mx4rvVjzG5wpEbGdrcN5Y29ycA VHOG:0001248 - Wikipedia:Circulatory_system uberon systema cardiovasculare UBERON:0001009 - circulatory system - http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg + http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]. - Wikipedia:Circulatory_system + - Wikipedia:Acoelomorpha + @@ -243636,26 +57940,26 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000959 - AAO - AAO:BJB + AAO + AAO:BJB We should divest ourselves of the view that earlier vertebrate groups were 'on their way' to becoming mammals, as clearly they were not such visionaries. Neither were their systems 'imperfect' as earlier anatomists thought. Instead, their circulatory systems served them well to address the ecological demands arising from their lifestyles.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001248 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.493 - http://bgee.unil.ch/ systema cardiovasculare - Wikipedia:Circulatory_system + @@ -243675,6 +57979,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -243698,6 +58003,9 @@ The modern definition of neurosecretion has evolved to include the release of an adipose In humans, adipose tissue is located beneath the skin (subcutaneous fat), around internal organs (visceral fat), in bone marrow (yellow bone marrow) and in breast tissue. Adipose tissue is found in specific locations, which are referred to as adipose depots. Adipose tissue contains several cell types, with the highest percentage of cells being adipocytes, which contain fat droplets. Other cell types include fibroblasts, macrophages, and endothelial cells. Adipose tissue contains many small blood vessels.; Mice have eight major adipose depots, four of which are within the abdominal cavity. The paired gonadal depots are attached to the uterus and ovaries in females and the epididymis and testes in males; the paired retroperitoneal depots are found along the dorsal wall of the abdomen, surrounding the kidney, and, when massive, extend into the pelvis. The mesenteric depot forms a glue-like web that supports the intestines, and the omental depot, which originates near the stomach and spleen, and, when massive, extends into the ventral abdomen. in FMA this is dense irregular connective tissue + + + AAO:0000001 AEO:000020 BTO:0001487 @@ -243713,11 +58021,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D000273 MIAA:0000015 NCIT:C12472 - SCTID:55603005 + OpenCyc:Mx4rvVjc_ZwpEbGdrcN5Y29ycA TAO:0002134 UMLS:C0001527 VHOG:0001284 - Wikipedia:Adipose_tissue XAO:0003049 ZFA:0005345 galen:FattyTissue @@ -243740,59 +58047,59 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Portion of connective tissue composed of adipocytes enmeshed in areolar tissue. + + MESH:A10.165.114 - MGI:cwg + MGI:cwg MP:0000003 - Wikipedia:Adipose_tissue - http://orcid.org/0000-0002-6601-2165 Connective tissue in which fat is stored.[TAO] - 2012-08-14 + 2012-08-14 TAO:0002134 - TAO - ZFIN:curator + TAO + ZFIN:curator Tissue that contains adipocytes, used for cushioning, thermal insulation, lubrication (primarily in the pericardium) and energy storage.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000001 - AAO - AAO:LAP + AAO + AAO:LAP relationship loss: subclass connective tissue proper (AAO:0000099)[AAO] - 2012-06-20 + 2012-06-20 AAO:0000001 - AAO + AAO Adipose tissue is unique to vertebrates. It is found in mostmammals, birds, reptiles and amphibians, and a variety is found in some species of fish. Furthermore, in insects the fat body found in larvae as well as in adults shares some homology with adipose tissue.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001284 - VHOG + VHOG + DOI:10.1017/S0029665107005423 Haugen F, Drevon CA, The interplay between nutrients and the adipose tissue. The Proceedings of the Nutrition Society (2007) - http://bgee.unil.ch/ in FMA this is dense irregular connective tissue - FMA + FMA @@ -243824,6 +58131,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -243840,6 +58148,8 @@ The modern definition of neurosecretion has evolved to include the release of an A subdivision of the muscular system corresponding to a subdisivision of an organism. In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here. + + AAO:0011066 BTO:0000887 EFO:0001949 @@ -243848,11 +58158,11 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:32558 MA:0000165 NCIT:C13056 + OpenCyc:Mx4rvVjmr5wpEbGdrcN5Y29ycA TAO:0000548 UMLS:C0026845 VSAO:0005038 WBbt:0005737 - Wikipedia:Muscular_system ZFA:0000548 muscle group muscles set @@ -243870,20 +58180,20 @@ The modern definition of neurosecretion has evolved to include the release of an musculature - http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png + http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png A subdivision of the muscular system corresponding to a subdisivision of an organism. - Wikipedia:Muscular_system - https://orcid.org/0000-0002-6601-2165 + + In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here. - FMA + FMA @@ -243896,7 +58206,7 @@ The modern definition of neurosecretion has evolved to include the release of an musculi FMA:32558 - FMA:TA + FMA:TA @@ -243918,6 +58228,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -243993,6 +58304,9 @@ The modern definition of neurosecretion has evolved to include the release of an Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG] nervous neural + + + AAO:0000324 BILA:0000079 BIRNLEX:844 @@ -244011,12 +58325,11 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D009420 MIAA:0000026 NCIT:C12755 - SCTID:278196006 + OpenCyc:Mx4rvViT_pwpEbGdrcN5Y29ycA TAO:0000396 UMLS:C0027763 VHOG:0000402 WBbt:0005735 - Wikipedia:Nervous_system XAO:0000177 ZFA:0000396 neuronames:3236 @@ -244031,8 +58344,8 @@ The modern definition of neurosecretion has evolved to include the release of an nervous system - http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg - http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png + http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg + http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png @@ -244043,47 +58356,47 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]. + BIRNLEX:844 ISBN:0-14-051288-8 ISBN:3110148986 NLM:nervous+system WB:rynl - Wikipedia:Nervous_system - ZFIN:curator + ZFIN:curator A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO] - 2012-08-14 + 2012-08-14 TAO:0000396 - TAO - ZFIN:curator + TAO + ZFIN:curator Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000324 - AAO - AAO:BJB + AAO + AAO:BJB Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000402 - VHOG + VHOG + ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.117 - http://bgee.unil.ch/ @@ -244101,13 +58414,13 @@ The modern definition of neurosecretion has evolved to include the release of an nerve net - Wikipedia:Nerve_net + systema nervosum - Wikipedia:Nervous_system + @@ -244164,6 +58477,9 @@ The modern definition of neurosecretion has evolved to include the release of an The brain and spinal cord. Kimmel et al, 1995.[TAO] The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO). (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG] + + + AAO:0000090 BAMS:CNS BILA:0000080 @@ -244183,11 +58499,10 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000457 MESH:D002490 NCIT:C12438 - SCTID:278199004 + OpenCyc:Mx4rvzYt3pwpEbGdrcN5Y29ycA TAO:0000012 UMLS:C0927232 VHOG:0000293 - Wikipedia:Central_nervous_system XAO:0000215 ZFA:0000012 neuronames:854 @@ -244209,7 +58524,7 @@ The modern definition of neurosecretion has evolved to include the release of an FBbt - cjm + cjm @@ -244220,39 +58535,39 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. + + GO:0021551 - http://www.frontiersinzoology.com/content/7/1/29 - https://sourceforge.net/p/geneontology/ontology-requests/11422/ - Wikipedia:Acoelomorpha + Part of the nervous system which includes the brain and spinal cord.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000090 - AAO - AAO:BJB + AAO + AAO:BJB The brain and spinal cord. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000012 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -244264,31 +58579,36 @@ The modern definition of neurosecretion has evolved to include the release of an (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000293 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 (reference 1), ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.165 (reference 2), DOI:10.1016/j.cell.2007.02.040 Denes AS, Jekely G, Steinmetz PRH, Raible F, Snyman H, Prud'homme B, Ferrier DEK, Balavoine G and Arendt D, Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in Bilateria. Cell (2007) (reference 3) - http://bgee.unil.ch/ UMLS:C0927232 BIRNLEX:1099 + + + + + UMLS:C0927232 ncithesaurus:Central_Nervous_System CNS - + systema nervosum centrale FMA:55675 - FMA:TA + FMA:TA @@ -244326,6 +58646,11 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of tissue which is a fasiculated group of axons.[TAO] nervous + + + + + AAO:0011070 AEO:0000137 BAMS:n @@ -244352,13 +58677,11 @@ The modern definition of neurosecretion has evolved to include the release of an NCIT:C12466 NCIT:C12768 NLX:147826 - SCTID:244457007 - SCTID:256864008 + OpenCyc:Mx4rwP3lkpwpEbGdrcN5Y29ycA TAO:0007009 UMLS:C0027740 UMLS:C0031119 VHOG:0000901 - Wikipedia:Nervous_system XAO:0000204 XAO:0003047 ZFA:0007009 @@ -244384,17 +58707,17 @@ The modern definition of neurosecretion has evolved to include the release of an An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures. + FBbt:00005105 - http://orcid.org/0000-0002-6601-2165 A portion of tissue which is a fasiculated group of axons.[TAO] - 2012-08-14 + 2012-08-14 TAO:0007009 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -244413,13 +58736,13 @@ The modern definition of neurosecretion has evolved to include the release of an nerves TAO:0007009 - + peripheral nerve - http://orcid.org/0000-0002-6601-2165 + @@ -244441,11 +58764,12 @@ The modern definition of neurosecretion has evolved to include the release of an A nerve that transmits from sensory receptors on the surface of the body to the central nervous system. + AEO:0000201 EHDAA2:0003200 FBbt:00005136 FMA:5868 - Wikipedia:Sensory_nerve + OpenCyc:Mx4rv0GdXpwpEbGdrcN5Y29ycA nervus sensorius uberon afferent nerve @@ -244463,20 +58787,20 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO A nerve that transmits from sensory receptors on the surface of the body to the central nervous system. - UBERON:cjm - Wikipedia:Sensory_nerve + + UBERON:cjm nervus sensorius - Wikipedia:Sensory_nerve + @@ -244485,7 +58809,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -244507,6 +58831,7 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information. An early step in the evolution of neural crest, therefore, may have been the origin of a specific dorsal neural cell population contributing to sensory processing; this would predate the divergence of the amphioxus and vertebrate lineages.[well established][VHOG] note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs + AAO:0000555 BAMS:SEN BILA:0000099 @@ -244521,7 +58846,6 @@ The modern definition of neurosecretion has evolved to include the release of an NLXANAT:090816 TAO:0000282 VHOG:0001674 - Wikipedia:Sensory_system XAO:0003194 ZFA:0000282 organa sensuum @@ -244539,30 +58863,30 @@ The modern definition of neurosecretion has evolved to include the release of an sensory system - http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png + http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information. - Wikipedia:Sensory_system + An early step in the evolution of neural crest, therefore, may have been the origin of a specific dorsal neural cell population contributing to sensory processing; this would predate the divergence of the amphioxus and vertebrate lineages.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001674 - VHOG + VHOG + DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000) - http://bgee.unil.ch/ organa sensuum FMA:75259 - FMA:TA + FMA:TA @@ -244582,13 +58906,13 @@ The modern definition of neurosecretion has evolved to include the release of an sensory systems TAO:0000282 - + organa sensuum - Wikipedia:Sensory_system + @@ -244624,6 +58948,9 @@ The modern definition of neurosecretion has evolved to include the release of an the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo; the yolk that it contains is the site of embryonic hematopoiesis and vitelline circulation is involved in early embryonic circulation; it is the origin of the primordial germ cells Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG] In therians, a structure homologous to the yolk sac is is present, but contains no yolk platelets. Instead it is filled with fluid [ISBN:0073040584 (Vertebrates, Kardong)] + + + BTO:0001471 CALOHA:TS-1130 EFO:0003078 @@ -244634,10 +58961,8 @@ The modern definition of neurosecretion has evolved to include the release of an GAID:1301 MESH:D015017 NCIT:C14128 - SCTID:362845002 UMLS:C0043425 VHOG:0000830 - Wikipedia:Yolk_sac uberon saccus vitellinus vesicula umbilicalis @@ -244646,19 +58971,19 @@ The modern definition of neurosecretion has evolved to include the release of an yolk sac - http://upload.wikimedia.org/wikipedia/commons/1/17/Gray22.png + http://upload.wikimedia.org/wikipedia/commons/1/17/Gray22.png - https://github.com/obophenotype/uberon/issues/635 + https://github.com/obophenotype/uberon/issues/635 - EHDAA2 + EHDAA2 @@ -244669,7 +58994,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ISBN:0073040584 + ISBN:0073040584 @@ -244680,23 +59005,23 @@ The modern definition of neurosecretion has evolved to include the release of an - ISBN:0073040584 + ISBN:0073040584 A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP]. - Wikipedia:Yolk_sac + One of the extraembryonic fetal membranes that balloons out from the fetal midgut. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000830 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/yolk+sac + VHOG + + @@ -244708,11 +59033,11 @@ The modern definition of neurosecretion has evolved to include the release of an Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000830 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.187 - http://bgee.unil.ch/ @@ -244724,14 +59049,14 @@ The modern definition of neurosecretion has evolved to include the release of an saccus vitellinus - Wikipedia:Yolk_sac + vesicula umbilicalis - Wikipedia:Yolk_sac + @@ -244745,6 +59070,9 @@ The modern definition of neurosecretion has evolved to include the release of an Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future. In vertebrates the term may refer to a developmental structure The anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder. The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] + + + AAO:0011042 BILA:0000085 BTO:0000507 @@ -244755,11 +59083,9 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:45616 MA:0001526 NCIT:C34180 - SCTID:361409009 TGMA:0001014 UMLS:C0231051 VHOG:0000285 - Wikipedia:Foregut XAO:0000232 uberon praeenteron @@ -244769,13 +59095,13 @@ The modern definition of neurosecretion has evolved to include the release of an foregut - http://upload.wikimedia.org/wikipedia/commons/9/9a/Gray27.png + http://upload.wikimedia.org/wikipedia/commons/9/9a/Gray27.png Anterior subdivision of a digestive tract. - http://orcid.org/0000-0002-6601-2165 + @@ -244787,11 +59113,11 @@ The modern definition of neurosecretion has evolved to include the release of an The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000285 - VHOG + VHOG + ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11 - http://bgee.unil.ch/ @@ -244803,14 +59129,14 @@ The modern definition of neurosecretion has evolved to include the release of an praeenteron - Wikipedia:Foregut + proenteron - Wikipedia:Foregut + @@ -244849,6 +59175,9 @@ The modern definition of neurosecretion has evolved to include the release of an (...) the earliest vertebrates possessed unjointed internal and external branchial arches, and musculature encircling the pharynx.[well established][VHOG] MA/FMA pharynx not part of digestive/alimentary system, we are consistent with this scheme pharynx + + + AAO:0000967 BTO:0001049 CALOHA:TS-0785 @@ -244862,11 +59191,10 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000432 MESH:D010614 NCIT:C12425 - SCTID:181211006 + OpenCyc:Mx4rvViv7ZwpEbGdrcN5Y29ycA TAO:0000056 UMLS:C0031354 VHOG:0000462 - Wikipedia:Pharynx XAO:0003227 ZFA:0000056 galen:Pharynx @@ -244888,13 +59216,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]. - http://www.feedexp.org + @@ -244906,19 +59234,19 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical cavity bounded by the derivatives of the branchial arches.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000967 - AAO - AAO:EJS + AAO + AAO:EJS Swollen region of the anterior foregut, posterior to the mouth and anterior to the liver; its walls form the jaws and gills. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000056 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -244930,42 +59258,42 @@ The modern definition of neurosecretion has evolved to include the release of an The portion of the alimentary canal between the mouth and the oesophagus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000462 - VHOG - http://bgee.unil.ch/ + VHOG + relationship type change: part_of_proxy respiratory system (AAO:0000541) CHANGED TO: develops_from respiratory system (UBERON:0001004)[AAO] - 2012-06-20 + 2012-06-20 AAO:0000967 - AAO + AAO relationship type change: part_of_proxy respiratory system (AAO:0000541) CHANGED TO: part_of respiratory system (UBERON:0001004)[AAO] - 2012-06-20 + 2012-06-20 AAO:0000967 - AAO + AAO (...) the earliest vertebrates possessed unjointed internal and external branchial arches, and musculature encircling the pharynx.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000462 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) Box essay 13.1 and Box figure I, p.502-503 - http://bgee.unil.ch/ MA/FMA pharynx not part of digestive/alimentary system, we are consistent with this scheme - MA + MA @@ -245021,11 +59349,13 @@ The modern definition of neurosecretion has evolved to include the release of an Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993). - Anterior end of the alimentary canal lined with smooth muscle. Bounded anteriorly by a constriction in the pharynx. Bounded posteriorly by and increase in circular and/or longitudinal smooth muscle associated with the stomach.[AAO] The few structural specializations in (adult lampreys) pharynx include complex valves on the external gill openings that direct the tidal flow, and the division of the ancestral pharynx into an oesophagus and a respiratory pharynx.[well established][VHOG] esophageal esophagus NOT part of gut in MA. part of gut in ZFA. part_of gut (via UGIT) in FMA. Consider splitting. Interspecies: The human oesophagus is 25 cm long and has a diameter of ca. 2 cm. Only little information was found on the oesophagus in rat, rabbit and pig. The oesophagus of rat (75 x 2 mm) and rabbit has no mucous glands and the cardia of the stomach has a well-developed sphincter, which prevents them from vomiting (Hebel and Stromberg, 1988; Manning et al., 1994). Morphologically the oesophagus is similar in man and pig; both are omnivores and have a non-keratinised epithelium, submucous glands and similar membrane enzymes. Like in humans, pigs can suffer from reflux oesophagitis and stress ulceration of the oesophagus. The pig oesophagus may therefore be a good model for investigation compared to the human oesophagus (Christie et al., 1995) + + + AAO:0000145 ANISEED:1235301 BTO:0000959 @@ -245042,11 +59372,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D004947 MIAA:0000048 NCIT:C12389 - SCTID:181245004 + OpenCyc:Mx4rvVj9Q5wpEbGdrcN5Y29ycA TAO:0000204 UMLS:C0014876 VHOG:0000450 - Wikipedia:Esophagus XAO:0000127 ZFA:0000204 galen:Esophagus @@ -245055,53 +59384,52 @@ The modern definition of neurosecretion has evolved to include the release of an uberon UBERON:0001043 - esophagus - http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg + http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg - FMA - MA + FMA + MA Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993). - Wikipedia:Esophagus - http://www.rivm.nl/interspeciesinfo/inter/oesophagus/ + + Anterior end of the alimentary canal lined with smooth muscle. Bounded anteriorly by a constriction in the pharynx. Bounded posteriorly by and increase in circular and/or longitudinal smooth muscle associated with the stomach.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000145 - AAO - AAO:EJS + AAO + AAO:EJS The few structural specializations in (adult lampreys) pharynx include complex valves on the external gill openings that direct the tidal flow, and the division of the ancestral pharynx into an oesophagus and a respiratory pharynx.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000450 - VHOG + VHOG + DOI:10.1111/j.1096-3642.1996.tb01658.x Mallatt J, Ventilation and the origin of jawed vertebrates: a new mouth. Zoological Journal of the Linnean Society (1996) - http://bgee.unil.ch/ esophagus NOT part of gut in MA. part of gut in ZFA. part_of gut (via UGIT) in FMA. Consider splitting. Interspecies: The human oesophagus is 25 cm long and has a diameter of ca. 2 cm. Only little information was found on the oesophagus in rat, rabbit and pig. The oesophagus of rat (75 x 2 mm) and rabbit has no mucous glands and the cardia of the stomach has a well-developed sphincter, which prevents them from vomiting (Hebel and Stromberg, 1988; Manning et al., 1994). Morphologically the oesophagus is similar in man and pig; both are omnivores and have a non-keratinised epithelium, submucous glands and similar membrane enzymes. Like in humans, pigs can suffer from reflux oesophagitis and stress ulceration of the oesophagus. The pig oesophagus may therefore be a good model for investigation compared to the human oesophagus (Christie et al., 1995) - MA + MA @@ -245133,6 +59461,9 @@ The modern definition of neurosecretion has evolved to include the release of an The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] In humans: originates from the foregut at the opening of the bile duct into the duodenum and continues through the small intestine and much of the large intestine until the transition to the hindgut about two-thirds of the way through the transverse colon in FMA this represents an embryonic region. + + + BILA:0000086 BTO:0000863 EFO:0001950 @@ -245143,11 +59474,9 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:45617 MA:0001564 NCIT:C34210 - SCTID:361410004 TGMA:0001036 UMLS:C0231052 VHOG:0000290 - Wikipedia:Midgut XAO:0000103 uberon mesenteron @@ -245157,36 +59486,36 @@ The modern definition of neurosecretion has evolved to include the release of an midgut - http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg + http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO]. + GO:0007494 - Wikipedia:Midgut The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000290 - VHOG + VHOG + ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11 - http://bgee.unil.ch/ In humans: originates from the foregut at the opening of the bile duct into the duodenum and continues through the small intestine and much of the large intestine until the transition to the hindgut about two-thirds of the way through the transverse colon - WP + WP in FMA this represents an embryonic region. - FMA + FMA @@ -245198,7 +59527,7 @@ The modern definition of neurosecretion has evolved to include the release of an mesenteron - Wikipedia:Midgut + @@ -245231,6 +59560,9 @@ The modern definition of neurosecretion has evolved to include the release of an the caudal portion of the primitive digestive tube of the embryo The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] in FMA this class has no children. In MA it has a single child hindgut epithelium + + + AAO:0011052 BILA:0000087 BTO:0000510 @@ -245241,11 +59573,9 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:45618 MA:0001527 NCIT:C34188 - SCTID:362856002 TGMA:0001020 UMLS:C0231053 VHOG:0000459 - Wikipedia:Hindgut XAO:0000104 uberon metenteron @@ -245254,7 +59584,7 @@ The modern definition of neurosecretion has evolved to include the release of an hindgut - http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray472.png + http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray472.png @@ -245265,13 +59595,13 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia The caudalmost subdivision of a digestive tract. - http://orcid.org/0000-0002-6601-2165 + @@ -245283,17 +59613,17 @@ The modern definition of neurosecretion has evolved to include the release of an The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000459 - VHOG + VHOG + ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11 - http://bgee.unil.ch/ in FMA this class has no children. In MA it has a single child hindgut epithelium - FMA + FMA @@ -245305,7 +59635,7 @@ The modern definition of neurosecretion has evolved to include the release of an metenteron - Wikipedia:Hindgut + @@ -245322,6 +59652,8 @@ The modern definition of neurosecretion has evolved to include the release of an Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]. + + AEO:0000171 BTO:0001886 EFO:0001652 @@ -245331,7 +59663,6 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000482 NCIT:C34275 UMLS:C0678727 - Wikipedia:Primordium XAO:0003043 uberon bud @@ -245349,16 +59680,16 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]. + BTO:0001886 FB:DJS FB:FBrf0089570 - http://flybase.org/reports/FBrf0178740.html @@ -245377,7 +59708,7 @@ The modern definition of neurosecretion has evolved to include the release of an primordia XAO:0003043 - + @@ -245400,6 +59731,9 @@ The modern definition of neurosecretion has evolved to include the release of an The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium + + + AAO:0010617 BTO:0001057 CALOHA:TS-2371 @@ -245414,11 +59748,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D054259 MIAA:0000069 NCIT:C34226 - SCTID:362852000 TAO:0001135 UMLS:C0231024 VHOG:0000307 - Wikipedia:Neural_tube XAO:0003204 ZFA:0001135 neuronames:1365 @@ -245431,48 +59763,48 @@ The modern definition of neurosecretion has evolved to include the release of an neural tube - http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png + http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - EHDAA2 + EHDAA2 In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]. - Wikipedia:Neural_tube + Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010617 - AAO + AAO AAO:JOR The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000307 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/neural+tube + VHOG + + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000307 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 - http://bgee.unil.ch/ @@ -245490,7 +59822,7 @@ The modern definition of neurosecretion has evolved to include the release of an tubus neuralis - Wikipedia:Neural_tube + @@ -245541,6 +59873,9 @@ The modern definition of neurosecretion has evolved to include the release of an The terminal portion of the large intestine between the ileo-pelvic colon and the anus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] rectal In the lungfish, sharks and rays the rectum opens into the cloaca which also receives wastes (urine) from the kidneys and material from the reproductive organs. In bony fish the rectum reaches the outside environment through the anus, which is normally situated just in front the urinary and reproductive openings. However in some fish the digestive tract may be curled back on itself, and in the Electric Eel (Electrophorus electricus) the anus is situated in the fish's throat. -- http://www.earthlife.net/fish/digestion.html + + + AAO:0010401 BTO:0001158 CALOHA:TS-1180 @@ -245556,10 +59891,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D012007 MIAA:0000050 NCIT:C12390 - SCTID:181261002 + OpenCyc:Mx4rvVjaU5wpEbGdrcN5Y29ycA UMLS:C0034896 VHOG:0001751 - Wikipedia:Rectum XAO:0000238 galen:Rectum terminal portion of intestine @@ -245573,16 +59907,14 @@ The modern definition of neurosecretion has evolved to include the release of an rectum - http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb + http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif 4 - cjm + cjm @@ -245593,7 +59925,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -245604,7 +59936,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -245615,24 +59947,24 @@ The modern definition of neurosecretion has evolved to include the release of an - ISBN:0073040584 + ISBN:0073040584 The terminal portion of the intestinal tube, terminating with the anus. - ISBN:0-683-40008-8 + + ISBN:0-683-40008-8 MP:0000492 - http://orcid.org/0000-0002-6601-2165 The terminal portion of the large intestine between the ileo-pelvic colon and the anus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001751 - VHOG - http://bgee.unil.ch/ + VHOG + @@ -245653,13 +59985,12 @@ The modern definition of neurosecretion has evolved to include the release of an + Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. - - - + + AAO:0010841 AEO:0000000 - BFO:0000004 BILA:0000000 BIRNLEX:6 CARO:0000000 @@ -245675,26 +60006,18 @@ The modern definition of neurosecretion has evolved to include the release of an WBbt:0000100 XAO:0000000 ZFA:0100000 - spatial uberon - CARO:0000000 UBERON:0001062 - anatomical entity + anatomical entity Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. - CARO:MAH - - - - - Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. + FMA:62955 - http://orcid.org/0000-0001-9114-8737 @@ -245741,11 +60064,15 @@ The modern definition of neurosecretion has evolved to include the release of an A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla. + in EHDAA2 this is an epithelium, in FMA the wall consists of epithelium and connective tissue These data show that ducts within the zebrafish pancreas originally arise in situ from isolated progenitor cells rather than arising from reiterative branching of the pancreatic epithelium. This process of pancreatic duct formation in zebrafish may be analogous to the mechanism of duct formation in the mammalian mammary and salivary glands. (...) A related mechanism of duct formation has also been proposed to occur within the mammalian pancreatic epithelium.[uncertain][VHOG] Upon reaching its final destination, the ventral pancreatic bud fuses with the much larger dorsal pancreatic bud. At this point of fusion, the main ducts of the ventral and dorsal pancreatic buds fuse, forming the duct of Wirsung, the main pancreatic duct. UBERON:0005627 pancreatic duct + + + BTO:0002362 EHDAA2:0001396 EHDAA:6905 @@ -245756,10 +60083,8 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D010183 NCIT:C12272 RETIRED_EHDAA2:0002177 - SCTID:245385001 UMLS:C0030288 VHOG:0000256 - Wikipedia:Pancreatic_duct chief pancreatic duct duct of Wirsung main pancreatic duct @@ -245770,15 +60095,14 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0001064 - EDITOR_NOTE in EHDAA2 this is an epithelium, in FMA the wall consists of epithelium and connective tissue ventral pancreatic duct - http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1100.png + http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1100.png - FMA + FMA @@ -245789,29 +60113,29 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla. - Wikipedia:Pancreatic_duct + These data show that ducts within the zebrafish pancreas originally arise in situ from isolated progenitor cells rather than arising from reiterative branching of the pancreatic epithelium. This process of pancreatic duct formation in zebrafish may be analogous to the mechanism of duct formation in the mammalian mammary and salivary glands. (...) A related mechanism of duct formation has also been proposed to occur within the mammalian pancreatic epithelium.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000256 - VHOG + VHOG + DOI:10.1016/j.ydbio.2005.04.035 Yee NS, Lorent K, Pack M, Exocrine pancreas development in zebrafish. Developmental Biology (2005) - http://bgee.unil.ch/ Upon reaching its final destination, the ventral pancreatic bud fuses with the much larger dorsal pancreatic bud. At this point of fusion, the main ducts of the ventral and dorsal pancreatic buds fuse, forming the duct of Wirsung, the main pancreatic duct. - WP + WP @@ -245835,7 +60159,7 @@ The modern definition of neurosecretion has evolved to include the release of an duct of Wirsung - Wikipedia:Pancreatic_duct + @@ -245886,11 +60210,12 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a back [Automatically generated definition]. + TODO - distinguish between entire skin of region and arbitrary zone of skin on region + EMAPA:36392 FMA:10462 FMA:22985 MA:0000498 - SCTID:181492002 back skin back zone of skin skin, dorsal region @@ -245898,14 +60223,13 @@ The modern definition of neurosecretion has evolved to include the release of an uberon UBERON:0001068 - EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region skin of back - MA + MA @@ -245916,31 +60240,31 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA A zone of skin that is part of a back [Automatically generated definition]. - OBOL:automatic + OBOL:automatic back zone of skin - OBOL:automatic + OBOL:automatic skin, dorsal region - https://orcid.org/0000-0002-6601-2165 + zone of skin of back - OBOL:automatic + OBOL:automatic @@ -245949,6 +60273,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -245976,6 +60301,9 @@ The modern definition of neurosecretion has evolved to include the release of an A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP]. not homologous to the external carotid of zebrafish (Goodrich, 1958) - http://zfish.nichd.nih.gov/zfatlas/Intro%20Page/comparative.html; check XAO + + + AAO:0010218 AAO:0010416 BTO:0004696 @@ -245987,10 +60315,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001929 MESH:D002342 NCIT:C32551 - SCTID:362044002 + OpenCyc:Mx4rwVJkPZwpEbGdrcN5Y29ycA UMLS:C0007275 VHOG:0000265 - Wikipedia:External_carotid_artery XAO:0000345 external carotid uberon @@ -246003,13 +60330,13 @@ The modern definition of neurosecretion has evolved to include the release of an external carotid artery https://sourceforge.net/tracker/?func=detail&aid=3486863&group_id=76834&atid=1127722 - http://upload.wikimedia.org/wikipedia/commons/1/13/External_carotid_a.gif + http://upload.wikimedia.org/wikipedia/commons/1/13/External_carotid_a.gif - MA + MA @@ -246020,7 +60347,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -246031,7 +60358,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -246042,13 +60369,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP]. - MGI:anna + MGI:anna @@ -246066,7 +60393,7 @@ The modern definition of neurosecretion has evolved to include the release of an arteria carotis externa - Wikipedia:External_carotid_artery + @@ -246101,13 +60428,14 @@ The modern definition of neurosecretion has evolved to include the release of an It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery. + + + EMAPA:37117 FMA:10665 MA:0002052 NCIT:C53005 - SCTID:161746006 UMLS:C0226271 - Wikipedia:Superficial_part_of_transverse_cervical_artery superficial branch of transverse cervical artery uberon UBERON:0001071 @@ -246120,13 +60448,13 @@ The modern definition of neurosecretion has evolved to include the release of an It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery. - Wikipedia:Superficial_part_of_transverse_cervical_artery + EMAPA:37117 - MA:th + MA:th @@ -246138,7 +60466,7 @@ The modern definition of neurosecretion has evolved to include the release of an superficial branch of transverse cervical artery - Wikipedia:Superficial_part_of_transverse_cervical_artery + @@ -246181,6 +60509,9 @@ The modern definition of neurosecretion has evolved to include the release of an Trunk of systemic vein which is formed by the union of the right common iliac vein and the left common iliac vein and terminates in the right atrium[FMA]. Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG] + + + AAO:0011083 BTO:0002682 EHDAA2:0000611 @@ -246190,10 +60521,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000480 MESH:D014682 NCIT:C12815 - SCTID:181369003 UMLS:C0042458 VHOG:0001194 - Wikipedia:Inferior_vena_cava XAO:0000388 galen:InferiorVenaCava inferior caval vein @@ -246208,20 +60537,20 @@ The modern definition of neurosecretion has evolved to include the release of an posterior vena cava - http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray577.png + http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray577.png - lexical + lexical A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart. - Wikipedia:Inferior_vena_cava - http://orcid.org/0000-0002-6601-2165 + + @@ -246233,11 +60562,11 @@ The modern definition of neurosecretion has evolved to include the release of an Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001194 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.454-455 - http://bgee.unil.ch/ @@ -246249,19 +60578,19 @@ The modern definition of neurosecretion has evolved to include the release of an inferior caval vein - http://orcid.org/0000-0002-6601-2165 + inferior vena cava - Wikipedia:Venae_cavae + posterior vena cava - Wikipedia:Venae_cavae + @@ -246273,10 +60602,15 @@ The modern definition of neurosecretion has evolved to include the release of an vena cava inferior - BTO:0002682 - Wikipedia:Inferior_vena_cava + + + + + vena cava inferior + BTO:0002682 + @@ -246324,10 +60658,10 @@ The modern definition of neurosecretion has evolved to include the release of an A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice. + EMAPA:37601 FMA:11338 MA:0000332 - SCTID:264021000 ileocaecal junction uberon UBERON:0001073 @@ -246337,13 +60671,13 @@ The modern definition of neurosecretion has evolved to include the release of an A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice. - http://www.medilexicon.com/medicaldictionary.php?t=46539 + EMAPA:37601 - MA:th + MA:th @@ -246372,7 +60706,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -246395,9 +60729,13 @@ The modern definition of neurosecretion has evolved to include the release of an A potential space between the visceral and parietal layers of the pericardium. + Anatomical space in which the heart is located and is surrounded by the pericardium.[TAO] In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart (of other tetrapods) is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG] check ZFA, should actually be thoracic cavity. Note that Hyman defines the cavity as the space between the heart and the sac (but defines the sac as parietal) + + + BSA:0000091 EHDAA2:0001434 EMAPA:16131 @@ -246405,11 +60743,9 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:11350 MA:0000053 NCIT:C38662 - SCTID:362027001 TAO:0002220 UMLS:C0225972 VHOG:0000556 - Wikipedia:Pericardial_cavity ZFA:0001655 galen:PericardialSpace cavity of pericardial sac @@ -246426,7 +60762,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -246437,7 +60773,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -246448,32 +60784,38 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia A potential space between the visceral and parietal layers of the pericardium. - Wikipedia:Pericardium + + + + + + + Anatomical space in which the heart is located and is surrounded by the pericardium.[TAO] - 2012-08-14 + 2012-08-14 TAO:0002220 - TAO - ZFIN:curator + TAO + ZFIN:curator In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart (of other tetrapods) is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000556 - VHOG + VHOG + ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206 - http://bgee.unil.ch/ @@ -246491,13 +60833,13 @@ The modern definition of neurosecretion has evolved to include the release of an pericardial space - Wikipedia:Pericardial_cavity + cavitas pericardiaca - Wikipedia:Pericardial_cavity + @@ -246540,10 +60882,10 @@ The modern definition of neurosecretion has evolved to include the release of an Endocardium that is part of the cardiac ventricle. + EMAPA:32747 FMA:12148 MA:0000079 - SCTID:192172004 TAO:0002247 VHOG:0000607 ZFA:0001615 @@ -246568,7 +60910,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2-abduced + EHDAA2-abduced @@ -246579,61 +60921,61 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + Endocardium that is part of the cardiac ventricle. - ZFIN:curator + ZFIN:curator cardiac ventricle endocardium - OBOL:automatic + OBOL:automatic endocardium of cardiac ventricle - OBOL:automatic + OBOL:automatic endocardium of heart ventricle - OBOL:automatic + OBOL:automatic endocardium of lower chamber of heart - OBOL:automatic + OBOL:automatic endocardium of ventricle of heart - OBOL:automatic + OBOL:automatic heart ventricle endocardium - OBOL:automatic + OBOL:automatic lower chamber of heart endocardium - OBOL:automatic + OBOL:automatic ventricle of heart endocardium - OBOL:automatic + OBOL:automatic @@ -246681,22 +61023,22 @@ The modern definition of neurosecretion has evolved to include the release of an An epicardial layer that lines a cardiac ventricle. - http://orcid.org/0000-0002-6601-2165 + The external layer of the ventricle bounding the ventricular myocardium. It is formed by a single layer of mesothelial cells supported by a basal lamina, and imbricated with collagen, fibroblasts, and vascular structures in the subepicardial space. Hu et al. 2001.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005058 - TAO - ZFIN:curator + TAO + ZFIN:curator cardiac ventricle epicardium - OBOL:automatic + OBOL:automatic @@ -246737,11 +61079,11 @@ The modern definition of neurosecretion has evolved to include the release of an Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer. Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer Hu et al. 2001.[TAO] As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[uncertain][VHOG] + EFO:0003088 EMAPA:32748 FMA:12151 MA:0000082 - SCTID:192084000 TAO:0005061 VHOG:0000604 ZFA:0005061 @@ -246764,32 +61106,32 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer. - ZFIN:curator + ZFIN:curator Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer Hu et al. 2001.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005061 - TAO - ZFIN:curator + TAO + ZFIN:curator As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000604 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481 - http://bgee.unil.ch/ @@ -246822,11 +61164,13 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a head [Automatically generated definition]. + TODO - distinguish between entire skin of region and arbitrary zone of skin on region + + FMA:12166 FMA:24756 MA:0000582 NCIT:C52757 - SCTID:181484006 UMLS:C0205029 adult head zone of skin head skin @@ -246835,14 +61179,13 @@ The modern definition of neurosecretion has evolved to include the release of an zone of skin of head uberon UBERON:0001084 - EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region skin of head A zone of skin that is part of a head [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -246854,25 +61197,25 @@ The modern definition of neurosecretion has evolved to include the release of an adult head zone of skin - OBOL:automatic + OBOL:automatic head zone of skin - OBOL:automatic + OBOL:automatic zone of skin of adult head - OBOL:automatic + OBOL:automatic zone of skin of head - OBOL:automatic + OBOL:automatic @@ -246899,13 +61242,14 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a trunk [Automatically generated definition]. - + TODO - distinguish between entire skin of region and arbitrary zone of skin on region + + EMAPA:37278 FMA:12167 FMA:23093 MA:0000517 NCIT:C12295 - SCTID:181489001 UMLS:C0205031 torso zone of skin trunk skin @@ -246914,21 +61258,19 @@ The modern definition of neurosecretion has evolved to include the release of an zone of skin of trunk uberon UBERON:0001085 - - EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region skin of trunk A zone of skin that is part of a trunk [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37278 - MA:th + MA:th @@ -246940,25 +61282,25 @@ The modern definition of neurosecretion has evolved to include the release of an torso zone of skin - OBOL:automatic + OBOL:automatic trunk zone of skin - OBOL:automatic + OBOL:automatic zone of skin of torso - OBOL:automatic + OBOL:automatic zone of skin of trunk - OBOL:automatic + OBOL:automatic @@ -246985,11 +61327,11 @@ The modern definition of neurosecretion has evolved to include the release of an Transudate contained in the pleural cavity. + BTO:0003080 FMA:12273 MA:0002532 MAT:0000500 - Wikipedia:Pleural_fluid ncithesaurus:Pleural_Fluid uberon UBERON:0001087 @@ -247043,6 +61385,8 @@ The modern definition of neurosecretion has evolved to include the release of an Portion of organism substance that is a clear fluid that occupies the space in synovial joints.[TAO] It provides nutrients and lubrication for articular cartilage The fluid contains hyaluronan secreted by fibroblast-like cells in the synovial membrane, lubricin (proteoglycan 4; PRG4) secreted by the surface chondrocytes of the articular cartilage and interstitial fluid filtered from the blood plasma + + BTO:0001339 CALOHA:TS-0996 ENVO:02000039 @@ -247053,7 +61397,6 @@ The modern definition of neurosecretion has evolved to include the release of an NCIT:C33718 TAO:0005154 UMLS:C0039097 - Wikipedia:Synovial_fluid ZFA:0005154 galen:SynovialFluid joint fluid @@ -247067,22 +61410,22 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Joint fluid is a transudate of plasma that is actively secreted by synovial cells. - https://www.ncbi.nlm.nih.gov/books/NBK274/ + Portion of organism substance that is a clear fluid that occupies the space in synovial joints.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005154 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -247094,7 +61437,7 @@ The modern definition of neurosecretion has evolved to include the release of an joint fluid - https://www.ncbi.nlm.nih.gov/books/NBK274/ + @@ -247110,11 +61453,13 @@ The modern definition of neurosecretion has evolved to include the release of an The first vertebral bone in the vertebral column. - First postcranial vertebra, which is modified anteriorly to articulate with the skull.[AAO] Vertebra that is posteriorly adjacent to the neurocranium.[TAO] 1 C1 + + + AAO:0000709 EHDAA:10606 EMAPA:19431 @@ -247123,10 +61468,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001421 MESH:D001270 NCIT:C32239 - SCTID:181818007 TAO:0001167 UMLS:C0004170 - Wikipedia:Atlas_(anatomy) ZFA:0001167 C1 vertebra atlas @@ -247139,7 +61482,6 @@ The modern definition of neurosecretion has evolved to include the release of an vertebra 1 uberon UBERON:0001092 - @@ -247149,25 +61491,25 @@ The modern definition of neurosecretion has evolved to include the release of an The first vertebral bone in the vertebral column. - http://orcid.org/0000-0002-6601-2165 + First postcranial vertebra, which is modified anteriorly to articulate with the skull.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000709 - AAO + AAO AAO:Duellman_and_Trueb_1994 Vertebra that is posteriorly adjacent to the neurocranium.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001167 - TAO - TAO:wd + TAO + TAO:wd @@ -247180,7 +61522,7 @@ The modern definition of neurosecretion has evolved to include the release of an atlas [C I] FMA:12519 - FMA:TA + FMA:TA @@ -247222,10 +61564,12 @@ The modern definition of neurosecretion has evolved to include the release of an The second vertebral bone in the vertebral column. - Vertebra that is posteriorly adjacent to vertebra 1.[TAO] not the same as ZFA term 'axis' 2 + + + EHDAA:10608 EMAPA:19432 FMA:12520 @@ -247233,10 +61577,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001422 MESH:D001368 NCIT:C32240 - SCTID:181819004 + OpenCyc:Mx4rv-zaJJwpEbGdrcN5Y29ycA TAO:0001168 UMLS:C0004457 - Wikipedia:Axis_(anatomy) ZFA:0001168 axis (CII) axis [C II] @@ -247250,7 +61593,6 @@ The modern definition of neurosecretion has evolved to include the release of an C2 axis UBERON:0001093 - @@ -247265,22 +61607,22 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The second vertebral bone in the vertebral column. - http://orcid.org/0000-0002-6601-2165 + Vertebra that is posteriorly adjacent to vertebra 1.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001168 - TAO - TAO:wd + TAO + TAO:wd @@ -247293,7 +61635,7 @@ The modern definition of neurosecretion has evolved to include the release of an axis [C II] FMA:12520 - FMA:TA + FMA:TA @@ -247349,20 +61691,21 @@ The modern definition of neurosecretion has evolved to include the release of an Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx). - Vertebrae bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae.[TAO] we deliberately merge the MA classes as we believe them equivalent UBERON:0006070 caudal vertebra + + + EMAPA:18374 FMA:12527 MA:0000310 MA:0001420 NCIT:C32334 - SCTID:361774004 + OpenCyc:Mx4rv9IEzZwpEbGdrcN5Y29ycA TAO:0000326 UMLS:C0223616 - Wikipedia:Caudal_vertebra XAO:0003079 ZFA:0000326 galen:CoccygealVertebra @@ -247376,7 +61719,6 @@ The modern definition of neurosecretion has evolved to include the release of an coccygea tail vertebra UBERON:0001095 - @@ -247387,22 +61729,22 @@ The modern definition of neurosecretion has evolved to include the release of an Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx). - http://orcid.org/0000-0002-6601-2165 + Vertebrae bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000326 - TAO - ZFIN:curator + TAO + ZFIN:curator we deliberately merge the MA classes as we believe them equivalent - MA + MA @@ -247421,7 +61763,7 @@ The modern definition of neurosecretion has evolved to include the release of an caudal vertebrae - + @@ -247433,7 +61775,7 @@ The modern definition of neurosecretion has evolved to include the release of an fused tail vertebra - https://orcid.org/0000-0002-6601-2165 + @@ -247495,67 +61837,67 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical wall that is part of a esophagus [Automatically generated definition]. - OBOL:automatic + OBOL:automatic anatomical wall of esophagus - OBOL:automatic + OBOL:automatic anatomical wall of gullet - OBOL:automatic + OBOL:automatic anatomical wall of oesophagus - OBOL:automatic + OBOL:automatic esophagus anatomical wall - OBOL:automatic + OBOL:automatic gullet anatomical wall - OBOL:automatic + OBOL:automatic gullet wall - OBOL:automatic + OBOL:automatic oesophagus anatomical wall - OBOL:automatic + OBOL:automatic oesophagus wall - OBOL:automatic + OBOL:automatic wall of gullet - OBOL:automatic + OBOL:automatic wall of oesophagus - OBOL:automatic + OBOL:automatic @@ -247633,6 +61975,9 @@ The modern definition of neurosecretion has evolved to include the release of an barrier between thoracic and abdominal cavities; stop gastric contents from refluxing into the oesophagus breathing control originate from the cervical somites, likely C3-C5[PMID:23586979] + + + BTO:0000341 CALOHA:TS-0198 EFO:0000937 @@ -247645,10 +61990,9 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000502 MESH:D003964 NCIT:C12702 - SCTID:181614006 + OpenCyc:Mx4rvVivz5wpEbGdrcN5Y29ycA UMLS:C0011980 VHOG:0000713 - Wikipedia:Thoracid_diaphragm diaphragm muscle diaphragm of thorax thoracic diaphragm @@ -247671,7 +62015,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:23586979 + @@ -247682,7 +62026,7 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional @@ -247694,7 +62038,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia:Thoracic_diaphragm#Comparative_anatomy_and_evolution + @@ -247706,11 +62050,11 @@ The modern definition of neurosecretion has evolved to include the release of an The mammals are characterized by a diaphragm, which separates the thoracic portion of the body cavity from the abdominal region and assists in drawing air into the lungs and forcing it out. Modern reptiles lack a muscular diaphragm and it is reasonable to suppose that the diaphragm developed as a new device that made possible a large degree of oxygen intake for active animals. The change may have taken place during the transition from reptile to mammal (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000713 - VHOG + VHOG + ISBN:978-0471384618 Colbert EH, Evolution of the vertebrates: a history of the backboned animals through time (2001) p.278 - http://bgee.unil.ch/ @@ -247752,13 +62096,14 @@ The modern definition of neurosecretion has evolved to include the release of an Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe. some work needs to be done to ensure the child terms of this class have correct isa/partof placement. in MA they are subclasses, in FMA they are parts + + + EMAPA:18306 FMA:13361 MA:0000360 NCIT:C49579 - SCTID:245378000 UMLS:C0447541 - Wikipedia:Liver#Lobes hepatic lobe liver lobe lobus hepatis @@ -247770,13 +62115,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe. - Wikipedia:Liver#Lobes + @@ -247793,17 +62138,18 @@ The modern definition of neurosecretion has evolved to include the release of an The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted]. Portion of the liver which develops on the fish's right side adjacent to the gall bladder.[TAO] + + + EHDAA2:0001008 EHDAA:4001 EMAPA:18311 FMA:13362 MA:0000363 NCIT:C33481 - SCTID:362182008 TAO:0005173 UMLS:C0227481 VHOG:0001424 - Wikipedia:Right_lobe_of_liver ZFA:0005173 liver right lobe lobus hepaticus dexter @@ -247818,24 +62164,22 @@ The modern definition of neurosecretion has evolved to include the release of an right lobe of liver - http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray1087-liver.png - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Liver.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Liver.glb + http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray1087-liver.png The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted]. - Wikipedia:Right_lobe_of_liver + Portion of the liver which develops on the fish's right side adjacent to the gall bladder.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005173 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -247872,7 +62216,7 @@ The modern definition of neurosecretion has evolved to include the release of an lobus hepatis dexter - Wikipedia:Right_lobe_of_liver + @@ -247896,17 +62240,18 @@ The modern definition of neurosecretion has evolved to include the release of an The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted]. Portion of the liver which develops on the fish's left side.[TAO] + + + EHDAA2:0001000 EHDAA:3995 EMAPA:18307 FMA:13363 MA:0000361 NCIT:C32965 - SCTID:362183003 TAO:0005172 UMLS:C0227486 VHOG:0001423 - Wikipedia:Left_lobe_of_liver ZFA:0005172 left liver lobe liver left lobe @@ -247918,24 +62263,22 @@ The modern definition of neurosecretion has evolved to include the release of an left lobe of liver - http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray1087-liver.png - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Liver.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Liver.glb + http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray1087-liver.png The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted]. - Wikipedia:Left_lobe_of_liver + Portion of the liver which develops on the fish's left side.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005172 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -247959,7 +62302,7 @@ The modern definition of neurosecretion has evolved to include the release of an lobus hepatis sinister - Wikipedia:Left_lobe_of_liver + @@ -247980,6 +62323,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -248023,11 +62367,14 @@ The modern definition of neurosecretion has evolved to include the release of an Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO]. Note that in contrast to VSAO, this is a subset of the skeletal system, and thus includes intervertebral joints, cartilage and ligaments etc. Some ontologies such as AAO seem to purely refer to the skeleton - Anatomical cluster that consists of all the vertebra in the body.[VSAO] The vertebral column consists of a series of vertebrae connected by ligaments. It provides a supporting axis for the body and protects the spinal cord. [TFD][VHOG] Vertebrata is characterized by three synapomorphies. First, vertebrates have a backbone composed of vertebrae (...).[well established][VHOG] spine + + + + AAO:0000699 AAO:0000734 BTO:0000818 @@ -248041,13 +62388,14 @@ The modern definition of neurosecretion has evolved to include the release of an NCIT:C12998 NCIT:C33588 NIF_Subcellular:sao1145756102 - SCTID:44300000 + OpenCyc:Mx4rv2j-CpwpEbGdrcN5Y29ycA + OpenCyc:Mx4rv6GF55wpEbGdrcN5Y29ycA + OpenCyc:Mx4rvVkFEpwpEbGdrcN5Y29ycA TAO:0001559 UMLS:C0037949 UMLS:C1519455 VHOG:0001142 VSAO:0000185 - Wikipedia:Vertebral_column XAO:0003074 ZFA:0001559 galen:SpinalColumn @@ -248060,7 +62408,6 @@ The modern definition of neurosecretion has evolved to include the release of an vertebral region UBERON:0001130 - @@ -248075,44 +62422,44 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO]. + + VSAO:0000185 - https://orcid.org/0000-0002-6601-2165 - https://sourceforge.net/tracker/?func=detail&aid=3530322&group_id=76834&atid=2257941 Anatomical cluster that consists of all the vertebra in the body.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000185 - VSAO + VSAO VSAO:curator The vertebral column consists of a series of vertebrae connected by ligaments. It provides a supporting axis for the body and protects the spinal cord. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001142 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/vertebral+column + VHOG + + Vertebrata is characterized by three synapomorphies. First, vertebrates have a backbone composed of vertebrae (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001142 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.53 - http://bgee.unil.ch/ @@ -248172,17 +62519,18 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - + + + + + @@ -248198,59 +62546,60 @@ The modern definition of neurosecretion has evolved to include the release of an - - + + - - + + A foramen within a vertebral element through which the spinal cord runs. It is formed by the anterior segment, and the posterior part, the vertebral arch. Opening on the vertebra for a spinal nerve as it emerges from the spinal canal.[AAO] + + AAO:0000729 EMAPA:37803 FMA:13479 MA:0001454 - SCTID:280734009 - Wikipedia:Vertebral_foramen + OpenCyc:Mx4rv_EvQZwpEbGdrcN5Y29ycA vertebra neural canal uberon foramen vertebrale UBERON:0001131 vertebral foramen - http://upload.wikimedia.org/wikipedia/commons/1/10/Foramenvertebrale.png + http://upload.wikimedia.org/wikipedia/commons/1/10/Foramenvertebrale.png A foramen within a vertebral element through which the spinal cord runs. It is formed by the anterior segment, and the posterior part, the vertebral arch. - Wikipedia:Vertebral_foramen - http://orcid.org/0000-0002-6601-2165 + + Opening on the vertebra for a spinal nerve as it emerges from the spinal canal.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000729 - AAO - AAO:LAP + AAO + AAO:LAP EMAPA:37803 - MA:th + MA:th foramen vertebrale - Wikipedia:Vertebral_foramen + @@ -248270,11 +62619,12 @@ The modern definition of neurosecretion has evolved to include the release of an - + + - + @@ -248293,6 +62643,7 @@ The modern definition of neurosecretion has evolved to include the release of an Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified]. check relationship with myocardium. part_of in MA - but we also have a more specific class 'cardiac muscle tissue of myocardium'. Check ncit UBERON:0007096 + AAO:0010245 AEO:0000142 BILA:0000134 @@ -248302,7 +62653,6 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:32688 FMA:14068 TAO:0005280 - Wikipedia:Cardiac_muscle ZFA:0005280 galen:CardiacMuscle galen:CardiacMuscleTissue @@ -248336,6 +62686,17 @@ The modern definition of neurosecretion has evolved to include the release of an cardiac muscle tissue + + + + + + + + + + ZFA + @@ -248346,121 +62707,121 @@ The modern definition of neurosecretion has evolved to include the release of an cardiac muscle muscle tissue - OBOL:automatic + OBOL:automatic cardiac muscle textus muscularis - OBOL:automatic + OBOL:automatic heart muscle muscle tissue - OBOL:automatic + OBOL:automatic heart muscle textus muscularis - OBOL:automatic + OBOL:automatic heart myocardium muscle tissue - OBOL:automatic + OBOL:automatic heart myocardium textus muscularis - OBOL:automatic + OBOL:automatic muscle of heart muscle tissue - OBOL:automatic + OBOL:automatic muscle of heart textus muscularis - OBOL:automatic + OBOL:automatic muscle tissue of cardiac muscle - OBOL:automatic + OBOL:automatic muscle tissue of heart muscle - OBOL:automatic + OBOL:automatic muscle tissue of heart myocardium - OBOL:automatic + OBOL:automatic muscle tissue of muscle of heart - OBOL:automatic + OBOL:automatic muscle tissue of myocardium - OBOL:automatic + OBOL:automatic myocardium muscle tissue - OBOL:automatic + OBOL:automatic myocardium textus muscularis - OBOL:automatic + OBOL:automatic textus muscularis of cardiac muscle - OBOL:automatic + OBOL:automatic textus muscularis of heart muscle - OBOL:automatic + OBOL:automatic textus muscularis of heart myocardium - OBOL:automatic + OBOL:automatic textus muscularis of muscle of heart - OBOL:automatic + OBOL:automatic textus muscularis of myocardium - OBOL:automatic + OBOL:automatic @@ -248514,13 +62875,14 @@ The modern definition of neurosecretion has evolved to include the release of an skeletal muscle + + + EMAPA:32716 FMA:14069 MA:0002439 NCIT:C13050 - SCTID:426215008 UMLS:C0242692 - Wikipedia:Skeletal_striated_muscle uberon skeletal muscle system somatic muscle @@ -248529,22 +62891,22 @@ The modern definition of neurosecretion has evolved to include the release of an skeletal muscle tissue - https://upload.wikimedia.org/wikipedia/commons/c/c0/Skeletal_muscle.jpg + https://upload.wikimedia.org/wikipedia/commons/c/c0/Skeletal_muscle.jpg Muscle tissue that consists primarily of skeletal muscle fibers. - https://github.com/obophenotype/uberon/issues/324 + Muscle, composed of long cylindrical, multinucleated cells that attaches to the skeleton via tendons.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005277 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -248557,11 +62919,11 @@ The modern definition of neurosecretion has evolved to include the release of an This result implies the following views in terms of evolutionary differentiation: (1) Arthropod striated muscle and vertebrate skeletal and cardiac muscles share a common ancestor. In other words, they did not evolve independently (...) (5) The divergence of vertebrate skeletal and cardiac muscles/vertebrate smooth muscle and nonmuscle is at least before that of vertebrates/arthropods. In other words, emergence of skeletal and cardiac musle type tissues preceded the vertebrate/arthropod divergence (ca. 700 MYA).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000319 - VHOG + VHOG + PMID:10368962 Oota S, Saitou N, Phylogenetic relationship of muscle tissues deduced from superimposition of gene trees. Mol Biol Evol (1999) - http://bgee.unil.ch/ @@ -248623,6 +62985,8 @@ The modern definition of neurosecretion has evolved to include the release of an Involuntary muscle tissue consisting of uninucleate spindle-shaped fibers.[AAO] (...) the first bilateral animals possessed only smooth muscles with the molecular repertoire necessary to build a striated muscle. (...) it is more parsimonious to regard striated muscle cells as a sister cell type to the smooth muscle cells. In this scenario, striated and smooth muscles would have arisen in the stem lineage that led to the Nephrozoa (i.e. all Bilateria exclusive the acoelomorphs) (Hejnol et al., 2009), from an 'acoel-like' smooth muscle, by segregation and divergence of functions and through differential recruitment of additional genes[well established][VHOG] GO uses visceral and smooth interchangeably. However visceral can also be used in the sense of the viscera. Many fly annotations to smooth muscle terms. If we want to be inclusive of insects have to have a general definition of tissue that includes cells. + + AAO:0010244 AEO:0000141 BTO:0001260 @@ -248638,11 +63002,11 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D009130 MIAA:0000303 NCIT:C12437 + OpenCyc:Mx4rvvSS3pwpEbGdrcN5Y29ycA TAO:0005274 UMLS:C1267092 VHOG:0001246 WBbt:0005781 - Wikipedia:Smooth_muscle_tissue XAO:0000175 ZFA:0005274 galen:SmoothMuscle @@ -248661,42 +63025,42 @@ The modern definition of neurosecretion has evolved to include the release of an smooth muscle tissue - https://upload.wikimedia.org/wikipedia/commons/3/3b/Glatte_Muskelzellen.jpg + https://upload.wikimedia.org/wikipedia/commons/3/3b/Glatte_Muskelzellen.jpg Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]. + GO:0006939 - Wikipedia:Smooth_muscle_tissue A non-striated muscle that is composed of spindle-shaped cells. Smooth muscle usually is organized into sheets that line cavitated organs.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005274 - TAO - ZFIN:curator + TAO + ZFIN:curator Involuntary muscle tissue consisting of uninucleate spindle-shaped fibers.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010244 - AAO + AAO AAO:CAM (...) the first bilateral animals possessed only smooth muscles with the molecular repertoire necessary to build a striated muscle. (...) it is more parsimonious to regard striated muscle cells as a sister cell type to the smooth muscle cells. In this scenario, striated and smooth muscles would have arisen in the stem lineage that led to the Nephrozoa (i.e. all Bilateria exclusive the acoelomorphs) (Hejnol et al., 2009), from an 'acoel-like' smooth muscle, by segregation and divergence of functions and through differential recruitment of additional genes[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001246 - VHOG + VHOG + DOI:10.1002/jez.b.21416 Chiodin M, Achatz JG, Wanninger A, Martinez P, Molecular architecture of muscles in an acoel and its evolutionary implications. Journal of Experimental Zoology (2011) - http://bgee.unil.ch/ @@ -248709,7 +63073,7 @@ The modern definition of neurosecretion has evolved to include the release of an textus muscularis nonstriatus FMA:14070 - FMA:TA + FMA:TA @@ -248728,7 +63092,7 @@ The modern definition of neurosecretion has evolved to include the release of an textus muscularis levis; textus muscularis nonstriatus - Wikipedia:Smooth_muscle_tissue + @@ -248773,6 +63137,9 @@ The modern definition of neurosecretion has evolved to include the release of an Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). + + + AEO:0000111 BTO:0002422 CALOHA:TS-1183 @@ -248787,14 +63154,12 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:14074 MA:0000565 NCIT:C33105 - SCTID:361918002 UMLS:C0086610 - Wikipedia:Mesothelium uberon UBERON:0001136 mesothelium - http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg + http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg @@ -248805,14 +63170,14 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). + FMA:14074 - Wikipedia:Mesothelium @@ -248836,6 +63201,9 @@ The modern definition of neurosecretion has evolved to include the release of an A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.. dorsal In humans, called the back, a large posterior area of the human body, rising from the top of the buttocks to the back of the neck and the shoulders. It is the surface opposite to the chest, its height being defined by the vertebral column (commonly referred to as the spine or backbone) and its breadth being supported by the ribcage and shoulders. The spinal canal runs through the spine and provides nerves to the rest of the body + + + BTO:0001713 CALOHA:TS-2223 EFO:0001405 @@ -248843,9 +63211,8 @@ The modern definition of neurosecretion has evolved to include the release of an GAID:30 MESH:D001415 NCIT:C13062 - SCTID:123961009 + OpenCyc:Mx4rvVkEU5wpEbGdrcN5Y29ycA UMLS:C0004600 - Wikipedia:Dorsum_(anatomy) galen:Back back back of body proper @@ -248855,15 +63222,15 @@ The modern definition of neurosecretion has evolved to include the release of an dorsum - http://upload.wikimedia.org/wikipedia/commons/e/ee/432px-Gray-back.PNG + http://upload.wikimedia.org/wikipedia/commons/e/ee/432px-Gray-back.PNG A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.. + BSPO:0000063 UBERONREF:0000006 - Wikipedia:Dorsum_(anatomy) @@ -248927,6 +63294,9 @@ The modern definition of neurosecretion has evolved to include the release of an In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]. + + + BTO:0002783 EHDAA2:0001951 EHDAA:5414 @@ -248934,10 +63304,9 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:14332 MA:0002179 NCIT:C33687 - SCTID:278031001 + OpenCyc:Mx4rwFjmM5wpEbGdrcN5Y29ycA UMLS:C0226742 VHOG:0000552 - Wikipedia:Superior_mesenteric_vein uberon upper mesenteric vein vena mesenterica superior @@ -248945,7 +63314,7 @@ The modern definition of neurosecretion has evolved to include the release of an superior mesenteric vein - http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png + http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png @@ -248956,13 +63325,13 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia:Vitelline_vein + In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]. - Wikipedia:Superior_mesenteric_vein + @@ -248980,7 +63349,7 @@ The modern definition of neurosecretion has evolved to include the release of an vena mesenterica superior - Wikipedia:Superior_mesenteric_vein + @@ -249029,6 +63398,9 @@ The modern definition of neurosecretion has evolved to include the release of an Vein that carries blood away from the liver[ZFA]. todo - add developmental relationships for other taxa + + + AAO:0010216 EMAPA:19221 FMA:14337 @@ -249036,10 +63408,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0003015 MESH:D006503 NCIT:C32736 - SCTID:278191001 + OpenCyc:Mx4rv5GivJwpEbGdrcN5Y29ycA TAO:0000670 UMLS:C0019155 - Wikipedia:Hepatic_vein XAO:0000387 ZFA:0000670 galen:HepaticVein @@ -249054,7 +63425,7 @@ The modern definition of neurosecretion has evolved to include the release of an hepatic vein - http://upload.wikimedia.org/wikipedia/commons/6/61/Gray1121.png + http://upload.wikimedia.org/wikipedia/commons/6/61/Gray1121.png @@ -249065,15 +63436,15 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA-abduced-lr + FMA-abduced-lr Vein that carries blood away from the liver[ZFA]. - Wikipedia:Hepatic_vein + + ZFA:0000670 - https://sourceforge.net/tracker/?func=detail&aid=3565355&group_id=76834&atid=1205376 @@ -249085,13 +63456,13 @@ The modern definition of neurosecretion has evolved to include the release of an liver vein - OBOL:automatic + OBOL:automatic vein of liver - OBOL:automatic + OBOL:automatic @@ -249103,13 +63474,13 @@ The modern definition of neurosecretion has evolved to include the release of an hepatic veins - + venae hepaticae - Wikipedia:Hepatic_vein + @@ -249150,13 +63521,15 @@ The modern definition of neurosecretion has evolved to include the release of an A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries. + + + EMAPA:18644 FMA:14346 MA:0002186 NCIT:C53058 - SCTID:278193003 + OpenCyc:Mx4rvrST5ZwpEbGdrcN5Y29ycA UMLS:C0226720 - Wikipedia:Ovarian_vein female reproductive system gonad vein female reproductive system gonada vein gonad of female reproductive system vein @@ -249173,13 +63546,13 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0001145 ovarian vein - http://upload.wikimedia.org/wikipedia/commons/c/cf/Ovarschaf.jpg + http://upload.wikimedia.org/wikipedia/commons/c/cf/Ovarschaf.jpg A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries. - Wikipedia:Ovarian_vein + @@ -249191,74 +63564,74 @@ The modern definition of neurosecretion has evolved to include the release of an female reproductive system gonad vein - OBOL:automatic + OBOL:automatic female reproductive system gonada vein - OBOL:automatic + OBOL:automatic gonad of female reproductive system vein - OBOL:automatic + OBOL:automatic gonada of female reproductive system vein - OBOL:automatic + OBOL:automatic ovary vein - OBOL:automatic + OBOL:automatic vein of female reproductive system gonad - OBOL:automatic + OBOL:automatic vein of female reproductive system gonada - OBOL:automatic + OBOL:automatic vein of gonad of female reproductive system - OBOL:automatic + OBOL:automatic vein of gonada of female reproductive system - OBOL:automatic + OBOL:automatic vein of ovary - OBOL:automatic + OBOL:automatic vena ovarica dextra - Wikipedia:Ovarian_vein + vena ovarica sinistra - Wikipedia:Ovarian_vein + @@ -249323,6 +63696,9 @@ The modern definition of neurosecretion has evolved to include the release of an The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct. Duct that connects the gall bladder and the common bile duct.[TAO] The duct of the gallbladder which joins the common hepatic duct, thus forming the common biliary duct. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] + + + EHDAA2:0000333 EHDAA:3045 EMAPA:16841 @@ -249331,11 +63707,10 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000355 MESH:D003549 NCIT:C32421 - SCTID:245398005 + OpenCyc:Mx4rveBeC5wpEbGdrcN5Y29ycA TAO:0005166 UMLS:C0010672 VHOG:0000213 - Wikipedia:Cystic_duct ZFA:0005166 galen:CysticDuct uberon @@ -249345,14 +63720,14 @@ The modern definition of neurosecretion has evolved to include the release of an cystic duct - http://upload.wikimedia.org/wikipedia/commons/4/48/Illu_liver_gallbladder.jpg - http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png + http://upload.wikimedia.org/wikipedia/commons/4/48/Illu_liver_gallbladder.jpg + http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png - FMA + FMA @@ -249363,7 +63738,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -249374,32 +63749,32 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0009493 Duct that connects the gall bladder and the common bile duct.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005166 - TAO + TAO ZFIN:Curator The duct of the gallbladder which joins the common hepatic duct, thus forming the common biliary duct. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000213 - VHOG - http://bgee.unil.ch/ + VHOG + @@ -249411,7 +63786,7 @@ The modern definition of neurosecretion has evolved to include the release of an ductus cysticus - Wikipedia:Cystic_duct + @@ -249449,6 +63824,9 @@ The modern definition of neurosecretion has evolved to include the release of an In mammals, the colon consists of four sections: the ascending colon, the transverse colon, the descending colon, and the sigmoid colon[WP] In zebrafish, the posterior intestine has short longitudinally arranged epithelial folds which are similar to the colon of higher vertebrates[ZFIN] it extracts water and salt from solid wastes before they are eliminated from the body[WP] + + + AAO:0010400 BTO:0000269 CALOHA:TS-0158 @@ -249462,11 +63840,10 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000526 MESH:D003106 NCIT:C12382 - SCTID:302508007 + OpenCyc:Mx4rvgLEM5wpEbGdrcN5Y29ycA TAO:0000706 UMLS:C0009368 VHOG:0000648 - Wikipedia:Colon_(anatomy) XAO:0000243 ZFA:0000706 galen:Colon @@ -249486,7 +63863,7 @@ The modern definition of neurosecretion has evolved to include the release of an 3 - cjm + cjm @@ -249497,50 +63874,50 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal. - Wikipedia:Colon_(anatomy) - ZFIN:curator - http://orcid.org/0000-0002-2825-0621 - http://orcid.org/0000-0002-6601-2165 + + + + ZFIN:curator Some references do not consider the caecum to be part of the colon. - http://orcid.org/0000-0002-1572-1316 + The last portion of the digestive system, it extracts water and salt from solid wastes before they are eliminated from the body.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010400 - AAO + AAO UBERON:0001155 The posterior intestine has short longitudinally arranged epithelial folds which are similar to the colon of higher vertebrates. Wallace et al, 2005.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000706 - TAO - ZFIN:curator + TAO + ZFIN:curator Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000648 - VHOG + VHOG + ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11 - http://bgee.unil.ch/ @@ -249569,6 +63946,10 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity. + + + + BTO:0000645 CALOHA:TS-2044 EFO:0000846 @@ -249579,10 +63960,9 @@ The modern definition of neurosecretion has evolved to include the release of an MIAA:0000314 NCIT:C12384 NCIT:C33550 - SCTID:362166007 + OpenCyc:Mx4rwHX_-5wpEbGdrcN5Y29ycA UMLS:C0227391 UMLS:C0682612 - Wikipedia:Sigmoid_colon galen:SigmoidColon uberon colon sigmoideum @@ -249594,15 +63974,13 @@ The modern definition of neurosecretion has evolved to include the release of an sigmoid colon - http://upload.wikimedia.org/wikipedia/commons/3/3b/Dickdarm-Schema.svg - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb + http://upload.wikimedia.org/wikipedia/commons/3/3b/Dickdarm-Schema.svg - FMA + FMA @@ -249613,13 +63991,13 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity. - Wikipedia:Sigmoid_colon + @@ -249637,7 +64015,7 @@ The modern definition of neurosecretion has evolved to include the release of an colon sigmoideum - Wikipedia:Sigmoid_colon + @@ -249649,14 +64027,15 @@ The modern definition of neurosecretion has evolved to include the release of an The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO]. we include this as zone of stomach even though it is not distinguished by gland type + + + BTO:0000505 EMAPA:35810 FMA:14560 MA:0002559 NCIT:C12258 - SCTID:362140009 UMLS:C0227230 - Wikipedia:Body_of_stomach galen:GastricCorpus corpus gastricum (ventriculare) gastric body @@ -249669,20 +64048,20 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0001161 body of stomach - http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg + http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg - FMA + FMA The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO]. + GO:0014845 - Wikipedia:Body_of_stomach @@ -249694,10 +64073,15 @@ The modern definition of neurosecretion has evolved to include the release of an corpus gastricum - BTO:0000505 - Wikipedia:Body_of_stomach + + + + + corpus gastricum + BTO:0000505 + @@ -249749,6 +64133,9 @@ The modern definition of neurosecretion has evolved to include the release of an The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells. antrum + + + BTO:0001732 EFO:0002555 EMAPA:17891 @@ -249757,9 +64144,7 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001624 MESH:D011706 NCIT:C12259 - SCTID:362142001 UMLS:C0034193 - Wikipedia:Pyloric_antrum galen:PyloricAntrum antrum of stomach stomach pyloric antrum @@ -249774,13 +64159,13 @@ The modern definition of neurosecretion has evolved to include the release of an pyloric antrum - http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg + http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg - FMA + FMA @@ -249791,13 +64176,13 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0010790 @@ -249822,10 +64207,15 @@ The modern definition of neurosecretion has evolved to include the release of an antrum pyloricum - BTO:0001732 - Wikipedia:Pyloric_antrum + + + + + antrum pyloricum + BTO:0001732 + @@ -249857,7 +64247,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -249888,6 +64277,9 @@ The modern definition of neurosecretion has evolved to include the release of an The orifice which allows the passage from the stomach into the intestine. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG] pyloric + + + BTO:0001146 EHDAA2:0001580 EHDAA:4860 @@ -249897,10 +64289,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002560 MESH:D011708 NCIT:C12260 - SCTID:362143006 UMLS:C0034196 VHOG:0000420 - Wikipedia:Pylorus galen:Pylorus pars pylorica pars pylorica gastricae @@ -249913,33 +64303,33 @@ The modern definition of neurosecretion has evolved to include the release of an pylorus - http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg + http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum. - MGI:csmith + MGI:csmith MP:0010785 The orifice which allows the passage from the stomach into the intestine. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000420 - VHOG - http://bgee.unil.ch/ + VHOG + Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000420 - VHOG + VHOG + ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11 - http://bgee.unil.ch/ @@ -249958,7 +64348,7 @@ The modern definition of neurosecretion has evolved to include the release of an pars pylorica gastricae FMA:14581 - FMA:TA + FMA:TA @@ -249971,7 +64361,7 @@ The modern definition of neurosecretion has evolved to include the release of an valvula pylori - Wikipedia:Pylorus + @@ -250005,10 +64395,10 @@ The modern definition of neurosecretion has evolved to include the release of an The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between. + EMAPA:35826 FMA:14582 MA:0002692 - SCTID:279995000 galen:WallOfStomach anatomical wall of stomach anatomical wall of ventriculus @@ -250027,44 +64417,44 @@ The modern definition of neurosecretion has evolved to include the release of an The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between. - MGI:csmith + MGI:csmith MP:0010783 anatomical wall of stomach - OBOL:automatic + OBOL:automatic anatomical wall of ventriculus - OBOL:automatic + OBOL:automatic stomach anatomical wall - OBOL:automatic + OBOL:automatic ventriculus anatomical wall - OBOL:automatic + OBOL:automatic ventriculus wall - OBOL:automatic + OBOL:automatic wall of ventriculus - OBOL:automatic + OBOL:automatic @@ -250091,6 +64481,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical wall that is part of a small intestine [Automatically generated definition]. + EMAPA:35785 FMA:14615 MA:0002696 @@ -250112,7 +64503,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical wall that is part of a small intestine [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -250124,37 +64515,37 @@ The modern definition of neurosecretion has evolved to include the release of an anatomical wall of small bowel - OBOL:automatic + OBOL:automatic anatomical wall of small intestine - OBOL:automatic + OBOL:automatic small bowel anatomical wall - OBOL:automatic + OBOL:automatic small bowel wall - OBOL:automatic + OBOL:automatic small intestine anatomical wall - OBOL:automatic + OBOL:automatic wall of small bowel - OBOL:automatic + OBOL:automatic @@ -250196,19 +64587,19 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical wall that is part of a large intestine [Automatically generated definition]. - OBOL:automatic + OBOL:automatic anatomical wall of large intestine - OBOL:automatic + OBOL:automatic large intestine anatomical wall - OBOL:automatic + OBOL:automatic @@ -250237,11 +64628,11 @@ The modern definition of neurosecretion has evolved to include the release of an The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP]. + + EMAPA:37745 FMA:14643 MA:0001555 - SCTID:245456008 - Wikipedia:Mesentery#Mesentery_.28proper.29 mesentery (proper) mesentery proper small intestinal mesentery @@ -250254,25 +64645,25 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP]. - Wikipedia:Mesentery#Mesentery_.28proper.29 + EMAPA:37745 - MA:th + MA:th mesentery (proper) - Wikipedia:Mesentery + @@ -250290,7 +64681,7 @@ The modern definition of neurosecretion has evolved to include the release of an small intestine mesentery - OBOL:automatic + OBOL:automatic @@ -250313,6 +64704,7 @@ The modern definition of neurosecretion has evolved to include the release of an The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel. + FMA:14653 MA:0002498 NCIT:C33341 @@ -250326,7 +64718,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -250337,8 +64729,8 @@ The modern definition of neurosecretion has evolved to include the release of an - MA - MP + MA + MP @@ -250380,11 +64772,12 @@ The modern definition of neurosecretion has evolved to include the release of an The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids. + + EMAPA:35497 FMA:14654 MA:0002496 NCIT:C32992 - SCTID:272214009 UMLS:C0227519 liver acinus portal acinus @@ -250396,7 +64789,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -250407,14 +64800,14 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids. - http://orcid.org/0000-0002-6601-2165 - http://www.vivo.colostate.edu/hbooks/pathphys/digestion/liver/histo_acinus.html + + @@ -250443,7 +64836,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -250491,12 +64883,13 @@ The modern definition of neurosecretion has evolved to include the release of an A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder. Hollow tree organ, the organ parts of which consist of the bile ducts.[AAO] + + + AAO:0011020 EMAPA:35172 FMA:14665 - SCTID:181267003 UMLS:C0005423 - Wikipedia:Biliary_tract XAO:0000455 uberon biliary tract @@ -250511,15 +64904,15 @@ The modern definition of neurosecretion has evolved to include the release of an A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder. - DOI:10.1002/ar.20664 + Hollow tree organ, the organ parts of which consist of the bile ducts.[AAO] - 2012-06-20 + 2012-06-20 AAO:0011020 - AAO + AAO UBERON:0001173 @@ -250575,6 +64968,9 @@ The modern definition of neurosecretion has evolved to include the release of an Digestive system duct that collects bile from the hepatic bile duct and the cystic duct.[TAO] The duct formed by the union of the common hepatic and cystic ducts. [Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, adapted_from_Dorian_AF][VHOG] + + + EHDAA2:0000303 EHDAA:3981 EMAPA:17201 @@ -250583,11 +64979,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001631 MESH:D003135 NCIT:C12698 - SCTID:362199009 TAO:0005165 UMLS:C0009437 VHOG:0000214 - Wikipedia:Common_bile_duct ZFA:0005165 galen:CommonBileDuct ductus choledochus (biliaris) @@ -250599,32 +64993,32 @@ The modern definition of neurosecretion has evolved to include the release of an common bile duct - http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png + http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct. - MGI:csmith + MGI:csmith MP:0009495 Digestive system duct that collects bile from the hepatic bile duct and the cystic duct.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005165 - TAO + TAO ZFIN:Curator The duct formed by the union of the common hepatic and cystic ducts. [Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, adapted_from_Dorian_AF][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000214 - VHOG - http://bgee.unil.ch/ + VHOG + @@ -250636,7 +65030,7 @@ The modern definition of neurosecretion has evolved to include the release of an ductus choledochus - Wikipedia:Common_bile_duct + @@ -250691,16 +65085,17 @@ The modern definition of neurosecretion has evolved to include the release of an Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP]. TODO - MA distinguishes between bile duct, hepatic duct, common bile duct and common hepatic duct. in FMA hepatic duct and common hepatic duct are the same. Common is part of extra-hepatic part The duct which conveys the bile from the liver and unites with the cystic duct to form the common bile duct. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] + + + EMAPA:19101 FMA:14668 GAID:286 MA:0002660 MESH:D006500 NCIT:C32356 - SCTID:245403006 UMLS:C0019149 VHOG:0000220 - Wikipedia:Common_hepatic_duct uberon ductus hepaticus communis hepatic duct @@ -250708,13 +65103,13 @@ The modern definition of neurosecretion has evolved to include the release of an common hepatic duct - http://upload.wikimedia.org/wikipedia/commons/4/48/Illu_liver_gallbladder.jpg + http://upload.wikimedia.org/wikipedia/commons/4/48/Illu_liver_gallbladder.jpg - FMA + FMA @@ -250725,7 +65120,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -250736,7 +65131,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia @@ -250747,7 +65142,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia @@ -250758,23 +65153,23 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP]. - Wikipedia:Common_hepatic_duct - ZFIN:curator + + ZFIN:curator The duct which conveys the bile from the liver and unites with the cystic duct to form the common bile duct. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000220 - VHOG - http://bgee.unil.ch/ + VHOG + @@ -250786,7 +65181,7 @@ The modern definition of neurosecretion has evolved to include the release of an ductus hepaticus communis - Wikipedia:Common_hepatic_duct + @@ -250821,13 +65216,14 @@ The modern definition of neurosecretion has evolved to include the release of an The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct. The duct which drains bile from the right half of the liver and unites with the left hepatic duct to form the common hepatic duct. [adapted_from_http://www.medterms.com/script/main/art.asp?articlekey=26032][VHOG] + + EHDAA2:0001727 EHDAA:3992 EMAPA:32797 FMA:14669 MA:0001639 NCIT:C33476 - SCTID:245401008 UMLS:C0227557 VHOG:0000217 uberon @@ -250839,16 +65235,16 @@ The modern definition of neurosecretion has evolved to include the release of an The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct. - http://www.medterms.com/script/main/art.asp?articlekey=26034 + The duct which drains bile from the right half of the liver and unites with the left hepatic duct to form the common hepatic duct. [adapted_from_http://www.medterms.com/script/main/art.asp?articlekey=26032][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000217 - VHOG - http://bgee.unil.ch/ + VHOG + @@ -250894,13 +65290,14 @@ The modern definition of neurosecretion has evolved to include the release of an The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct. The duct which drains bile from the left half of the liver and unites with the right hepatic duct to form the common hepatic duct. [adapted_from_http://www.medterms.com/script/main/art.asp?articlekey=26032][VHOG] + + EHDAA2:0000941 EHDAA:3990 EMAPA:32795 FMA:14670 MA:0001638 NCIT:C32960 - SCTID:245400009 UMLS:C0227560 VHOG:0000218 uberon @@ -250912,16 +65309,16 @@ The modern definition of neurosecretion has evolved to include the release of an The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct. - http://www.medterms.com/script/main/art.asp?articlekey=26035 + The duct which drains bile from the left half of the liver and unites with the right hepatic duct to form the common hepatic duct. [adapted_from_http://www.medterms.com/script/main/art.asp?articlekey=26032][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000218 - VHOG - http://bgee.unil.ch/ + VHOG + @@ -250960,12 +65357,12 @@ The modern definition of neurosecretion has evolved to include the release of an The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space. + + EMAPA:16592 FMA:14703 - SCTID:362702003 TAO:0005132 VHOG:0001528 - Wikipedia:Visceral_peritoneum ZFA:0005132 visceral serous membrane of peritoneum uberon @@ -250973,20 +65370,20 @@ The modern definition of neurosecretion has evolved to include the release of an visceral peritoneum - http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png + http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space. - Wikipedia:Peritoneum#Types - http://orcid.org/0000-0002-6601-2165 + + visceral serous membrane of peritoneum - UBERON:cjm + UBERON:cjm @@ -251013,6 +65410,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -251047,6 +65445,9 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical cavity bounded by visceral and parietal peritoneum. The potential space between the parietal and visceral layers of the peritoneum, which are normally in contact. The peritoneal cavity is divided into the greater and lesser sac. The greater sac is the peritoneal cavity, and the lesser sac is the omental bursa. [TFD][VHOG] In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart [of other tetrapods] is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes) Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG] + + + BTO:0001782 EHDAA2:0001446 EMAPA:16138 @@ -251055,10 +65456,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000054 MESH:D010529 NCIT:C12769 - SCTID:181616008 UMLS:C1704247 VHOG:0000852 - Wikipedia:Peritoneal_cavity uberon cavitas peritonealis saccus serosus peritonei @@ -251076,35 +65475,35 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia Anatomical cavity bounded by visceral and parietal peritoneum. - Wikipedia:Peritoneal_cavity - http://orcid.org/0000-0002-6601-2165 - https://github.com/obophenotype/uberon/issues/86 + + + The potential space between the parietal and visceral layers of the peritoneum, which are normally in contact. The peritoneal cavity is divided into the greater and lesser sac. The greater sac is the peritoneal cavity, and the lesser sac is the omental bursa. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000852 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/peritoneal+cavity + VHOG + + In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart [of other tetrapods] is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes) Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000852 - VHOG + VHOG + ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206 - http://bgee.unil.ch/ @@ -251116,15 +65515,20 @@ The modern definition of neurosecretion has evolved to include the release of an cavitas peritonealis - BTO:0001782 - Wikipedia:Peritoneal_cavity + + + + + cavitas peritonealis + BTO:0001782 + saccus serosus peritonei - Wikipedia:Peritoneal_cavity + @@ -251166,13 +65570,15 @@ The modern definition of neurosecretion has evolved to include the release of an An artery that supplies an ovary. In human anatomy, the ovarian artery is a blood vessel that supplies oxygenated blood to the ovary. It arises from the abdominal aorta below the renal artery, and does not pass out of the abdomiproperty_value external_definitioncavity. It can be found in the suspensory ligament of the ovary. [WP]. + + + EMAPA:18620 FMA:14761 MA:0002012 NCIT:C33242 - SCTID:244280002 + OpenCyc:Mx4rwOa9PZwpEbGdrcN5Y29ycA UMLS:C0226411 - Wikipedia:Ovarian_artery ovarian arterial tree uberon arteria ovarica @@ -251180,19 +65586,19 @@ The modern definition of neurosecretion has evolved to include the release of an ovarian artery - http://upload.wikimedia.org/wikipedia/commons/a/ae/Gray1170.png + http://upload.wikimedia.org/wikipedia/commons/a/ae/Gray1170.png An artery that supplies an ovary. - OBOL:automatic + OBOL:automatic In human anatomy, the ovarian artery is a blood vessel that supplies oxygenated blood to the ovary. It arises from the abdominal aorta below the renal artery, and does not pass out of the abdomiproperty_value external_definitioncavity. It can be found in the suspensory ligament of the ovary. [WP]. - Wikipedia:Ovarian_artery + @@ -251204,7 +65610,7 @@ The modern definition of neurosecretion has evolved to include the release of an arteria ovarica - Wikipedia:Ovarian_artery + @@ -251241,6 +65647,8 @@ The modern definition of neurosecretion has evolved to include the release of an currently defined in a generic fashion. Artery that supplies blood to the liver.[TAO] + + BTO:0004307 EMAPA:17859 FMA:14769 @@ -251248,7 +65656,7 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001963 MESH:D006499 NCIT:C32729 - SCTID:76015000 + OpenCyc:Mx4rvzKtFpwpEbGdrcN5Y29ycA TAO:0005161 UMLS:C0019145 ZFA:0005161 @@ -251261,23 +65669,23 @@ The modern definition of neurosecretion has evolved to include the release of an hepatic artery - http://upload.wikimedia.org/wikipedia/commons/4/4c/Common_and_proper_hepatic_artery.png + http://upload.wikimedia.org/wikipedia/commons/4/4c/Common_and_proper_hepatic_artery.png An artery that supplies the liver. - Wikipedia:Hepatic_artery_proper - https://orcid.org/0000-0002-6601-2165 + + Artery that supplies blood to the liver.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005161 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -251314,11 +65722,11 @@ The modern definition of neurosecretion has evolved to include the release of an - + - + @@ -251329,13 +65737,16 @@ The modern definition of neurosecretion has evolved to include the release of an - + An artery that supplies the spleen. + + + EMAPA:19216 FMA:14773 GAID:510 @@ -251343,9 +65754,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0003177 MESH:D013157 NCIT:C33597 - SCTID:244266009 + OpenCyc:Mx4rv0cb2ZwpEbGdrcN5Y29ycA UMLS:C0037996 - Wikipedia:Splenic_artery galen:SplenicArtery arteria splenica lienal artery @@ -251356,15 +65766,13 @@ The modern definition of neurosecretion has evolved to include the release of an splenic artery https://github.com/obophenotype/uberon/issues/268 - http://upload.wikimedia.org/wikipedia/commons/a/a2/Gray1188.png - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb + http://upload.wikimedia.org/wikipedia/commons/a/a2/Gray1188.png An artery that supplies the spleen. - http://orcid.org/0000-0002-6601-2165 + @@ -251376,7 +65784,7 @@ The modern definition of neurosecretion has evolved to include the release of an arteria splenica - Wikipedia:Splenic_artery + @@ -251389,7 +65797,7 @@ The modern definition of neurosecretion has evolved to include the release of an arteria lienalis - Wikipedia:Splenic_artery + @@ -251436,6 +65844,9 @@ The modern definition of neurosecretion has evolved to include the release of an The mucosal layer that lines the stomach. The gastric mucosa is the mucous membrane layer of the stomach which contains the glands and the gastric pits. In men it is about 1 mm thick and its surface is smooth, soft, and velvety. It consists of epithelium, lamina propria, and the muscularis mucosae. In its fresh state, it is of a pinkish tinge at the pyloric end and of a red or reddish-brown color over the rest of its surface. In infancy it is of a brighter hue, the vascular redness being more marked. It is thin at the cardiac extremity, but thicker toward the pylorus. During the contracted state of the organ it is thrown into numerous plaits or rugae, which, for the most part, have a longitudinal direction, and are most marked toward the pyloric end of the stomach, and along the greater curvature. These folds are entirely obliterated when the organ becomes distended. When examined with a lens, the inner surface of the mucous membrane presents a peculiar honeycomb appearance from being covered with funnel-like depressions or foveolae of a polygonal or hexagonal form, which vary from 0.12 to 0.25 mm. in diameter. These are the ducts of the gastric glands, and at the bottom of each may be seen one or more minute orifices, the openings of the gland tubes. Gastric glands are simple or branched tubular glands that emerge on the deeper part of the gastric foveola, inside the gastric areas and outlined by the folds of the mucosa. There are three types of glands: cardiac glands (in the proximal part of the stomach), oxyntic glands (the dominating type of gland), and pyloric glands. The cardiac glands mainly contain mucus producing cells. The bottom part of the oxyntic glands is dominated by zymogen (chief) cells that produce pepsinogen (an inactive precursor of the pepsin enzyme). Parietal cells, which secrete hydrochloric acid are scattered in the glands, with most of them in the middle part. The upper part of the glands consist of mucous neck cells; in this part the dividing cells are seen. The pyloric glands contain mucus-secreting cells. Several types of endocrine cells are found in all regions of the gastric mucosa. In the pyloric glands contain gastrin producing cells (G cells); this hormone stimulates acid production from the parietal cells. ECL (enterochromaffine-like) cells, found in the oxyntic glands release histamine, which also is a powerful stimulant of the acid secretion. The A cells produce glucagon, which mobilizes the hepatic glycogen, and the enterochromaffin cells that produce serotonin, which stimulates the contraction of the smooth muscles. The surface of the mucous membrane is covered by a single layer of columnar epithelium . This epithelium commences very abruptly at the cardiac orifice, where there is a sudden transition from the stratified epithelium of the esophagus. The epithelial lining of the gland ducts is of the same character and is continuous with the general lining of the stomach. [WP,unvetted][Wikipedia:Gastric_mucosa]. + + + BTO:0001308 CALOHA:TS-0404 EMAPA:35817 @@ -251444,9 +65855,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002683 MESH:D005753 NCIT:C32656 - SCTID:362131005 + OpenCyc:Mx8NhB4rvcD6KJwpEbGdrcN5Y29ycB4rvmKNOpwpEbGdrcN5Y29ycB4rvVj5FpwpEbGdrcN5Y29ycB4rvVjlqpwpEbGdrcN5Y29ycA UMLS:C0017136 - Wikipedia:Gastric_mucosa galen:GastricMucosa gastric mucosa gastric mucous membrane @@ -251474,19 +65884,19 @@ The modern definition of neurosecretion has evolved to include the release of an mucosa of stomach - https://upload.wikimedia.org/wikipedia/commons/1/1c/Normal_gastric_mucosa_intermed_mag.jpg + https://upload.wikimedia.org/wikipedia/commons/1/1c/Normal_gastric_mucosa_intermed_mag.jpg The mucosal layer that lines the stomach. - http://orcid.org/0000-0002-6601-2165 + The gastric mucosa is the mucous membrane layer of the stomach which contains the glands and the gastric pits. In men it is about 1 mm thick and its surface is smooth, soft, and velvety. It consists of epithelium, lamina propria, and the muscularis mucosae. In its fresh state, it is of a pinkish tinge at the pyloric end and of a red or reddish-brown color over the rest of its surface. In infancy it is of a brighter hue, the vascular redness being more marked. It is thin at the cardiac extremity, but thicker toward the pylorus. During the contracted state of the organ it is thrown into numerous plaits or rugae, which, for the most part, have a longitudinal direction, and are most marked toward the pyloric end of the stomach, and along the greater curvature. These folds are entirely obliterated when the organ becomes distended. When examined with a lens, the inner surface of the mucous membrane presents a peculiar honeycomb appearance from being covered with funnel-like depressions or foveolae of a polygonal or hexagonal form, which vary from 0.12 to 0.25 mm. in diameter. These are the ducts of the gastric glands, and at the bottom of each may be seen one or more minute orifices, the openings of the gland tubes. Gastric glands are simple or branched tubular glands that emerge on the deeper part of the gastric foveola, inside the gastric areas and outlined by the folds of the mucosa. There are three types of glands: cardiac glands (in the proximal part of the stomach), oxyntic glands (the dominating type of gland), and pyloric glands. The cardiac glands mainly contain mucus producing cells. The bottom part of the oxyntic glands is dominated by zymogen (chief) cells that produce pepsinogen (an inactive precursor of the pepsin enzyme). Parietal cells, which secrete hydrochloric acid are scattered in the glands, with most of them in the middle part. The upper part of the glands consist of mucous neck cells; in this part the dividing cells are seen. The pyloric glands contain mucus-secreting cells. Several types of endocrine cells are found in all regions of the gastric mucosa. In the pyloric glands contain gastrin producing cells (G cells); this hormone stimulates acid production from the parietal cells. ECL (enterochromaffine-like) cells, found in the oxyntic glands release histamine, which also is a powerful stimulant of the acid secretion. The A cells produce glucagon, which mobilizes the hepatic glycogen, and the enterochromaffin cells that produce serotonin, which stimulates the contraction of the smooth muscles. The surface of the mucous membrane is covered by a single layer of columnar epithelium . This epithelium commences very abruptly at the cardiac orifice, where there is a sudden transition from the stratified epithelium of the esophagus. The epithelial lining of the gland ducts is of the same character and is continuous with the general lining of the stomach. [WP,unvetted][Wikipedia:Gastric_mucosa]. - Wikipedia:Gastric_mucosa + @@ -251498,87 +65908,87 @@ The modern definition of neurosecretion has evolved to include the release of an mucosa of organ of stomach - OBOL:automatic + OBOL:automatic mucosa of organ of ventriculus - OBOL:automatic + OBOL:automatic mucosa of ventriculus - OBOL:automatic + OBOL:automatic mucous membrane of ventriculus - OBOL:automatic + OBOL:automatic organ mucosa of stomach - OBOL:automatic + OBOL:automatic organ mucosa of ventriculus - OBOL:automatic + OBOL:automatic stomach mucosa of organ - OBOL:automatic + OBOL:automatic stomach mucous membrane - OBOL:automatic + OBOL:automatic stomach organ mucosa - OBOL:automatic + OBOL:automatic tunica mucosa gastricae FMA:14907 - FMA:TA + FMA:TA ventriculus mucosa - OBOL:automatic + OBOL:automatic ventriculus mucosa of organ - OBOL:automatic + OBOL:automatic ventriculus mucous membrane - OBOL:automatic + OBOL:automatic ventriculus organ mucosa - OBOL:automatic + OBOL:automatic @@ -251590,10 +66000,15 @@ The modern definition of neurosecretion has evolved to include the release of an tunica mucosa gastris - BTO:0001308 - Wikipedia:Gastric_mucosa + + + + + tunica mucosa gastris + BTO:0001308 + @@ -251631,12 +66046,13 @@ The modern definition of neurosecretion has evolved to include the release of an The fibrous connective tissue layer beneath the stomach mucosa. + + BTO:0002110 EMAPA:35825 FMA:14908 MA:0002685 NCIT:C32663 - SCTID:52459002 UMLS:C0227211 gastric submucosa stomach submucosa @@ -251655,7 +66071,7 @@ The modern definition of neurosecretion has evolved to include the release of an The fibrous connective tissue layer beneath the stomach mucosa. - MGI:csmith + MGI:csmith MP:0010794 @@ -251668,21 +66084,21 @@ The modern definition of neurosecretion has evolved to include the release of an submucosa of ventriculus - OBOL:automatic + OBOL:automatic tela submucosa gastricae FMA:14908 - FMA:TA + FMA:TA ventriculus submucosa - OBOL:automatic + OBOL:automatic @@ -251728,11 +66144,12 @@ The modern definition of neurosecretion has evolved to include the release of an The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum. TODO - check serosa/peritoneum + + EMAPA:35822 FMA:14914 MA:0001626 NCIT:C32662 - SCTID:1353004 UMLS:C1517453 anatomical wall of stomach serosa anatomical wall of stomach serous membrane @@ -251785,7 +66202,7 @@ The modern definition of neurosecretion has evolved to include the release of an The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum. - MGI:csmith + MGI:csmith MP:0010793 @@ -251798,225 +66215,225 @@ The modern definition of neurosecretion has evolved to include the release of an anatomical wall of stomach serosa - OBOL:automatic + OBOL:automatic anatomical wall of stomach serous membrane - OBOL:automatic + OBOL:automatic anatomical wall of ventriculus serosa - OBOL:automatic + OBOL:automatic anatomical wall of ventriculus serous membrane - OBOL:automatic + OBOL:automatic gastric wall serosa - OBOL:automatic + OBOL:automatic gastric wall serous membrane - OBOL:automatic + OBOL:automatic serosa of anatomical wall of stomach - OBOL:automatic + OBOL:automatic serosa of anatomical wall of ventriculus - OBOL:automatic + OBOL:automatic serosa of gastric wall - OBOL:automatic + OBOL:automatic serosa of stomach anatomical wall - OBOL:automatic + OBOL:automatic serosa of stomach wall - OBOL:automatic + OBOL:automatic serosa of ventriculus anatomical wall - OBOL:automatic + OBOL:automatic serosa of ventriculus wall - OBOL:automatic + OBOL:automatic serosa of wall of stomach - OBOL:automatic + OBOL:automatic serosa of wall of ventriculus - OBOL:automatic + OBOL:automatic serous membrane of anatomical wall of stomach - OBOL:automatic + OBOL:automatic serous membrane of anatomical wall of ventriculus - OBOL:automatic + OBOL:automatic serous membrane of gastric wall - OBOL:automatic + OBOL:automatic serous membrane of stomach anatomical wall - OBOL:automatic + OBOL:automatic serous membrane of stomach wall - OBOL:automatic + OBOL:automatic serous membrane of ventriculus anatomical wall - OBOL:automatic + OBOL:automatic serous membrane of ventriculus wall - OBOL:automatic + OBOL:automatic serous membrane of wall of stomach - OBOL:automatic + OBOL:automatic serous membrane of wall of ventriculus - OBOL:automatic + OBOL:automatic stomach anatomical wall serosa - OBOL:automatic + OBOL:automatic stomach anatomical wall serous membrane - OBOL:automatic + OBOL:automatic stomach wall serosa - OBOL:automatic + OBOL:automatic stomach wall serous membrane - OBOL:automatic + OBOL:automatic tunica serosa gastricae FMA:14914 - FMA:TA + FMA:TA ventriculus anatomical wall serosa - OBOL:automatic + OBOL:automatic ventriculus anatomical wall serous membrane - OBOL:automatic + OBOL:automatic ventriculus wall serosa - OBOL:automatic + OBOL:automatic ventriculus wall serous membrane - OBOL:automatic + OBOL:automatic wall of stomach serosa - OBOL:automatic + OBOL:automatic wall of stomach serous membrane - OBOL:automatic + OBOL:automatic wall of ventriculus serosa - OBOL:automatic + OBOL:automatic wall of ventriculus serous membrane - OBOL:automatic + OBOL:automatic @@ -252079,12 +66496,14 @@ The modern definition of neurosecretion has evolved to include the release of an A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP]. (...) the adult Xenopus stomach exhibits both glandular and aglandular regions and a distinct pyloric sphincter similar to that of the amniotic vertebrates (...).[uncertain][VHOG] + + AAO:0011093 EMAPA:19251 FMA:14916 MA:0002952 NCIT:C33433 - SCTID:268073008 + OpenCyc:Mx4rvly2ZZwpEbGdrcN5Y29ycA UMLS:C0227238 VHOG:0001466 XAO:0000457 @@ -252099,17 +66518,17 @@ The modern definition of neurosecretion has evolved to include the release of an A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP]. - https://orcid.org/0000-0002-6601-2165 + (...) the adult Xenopus stomach exhibits both glandular and aglandular regions and a distinct pyloric sphincter similar to that of the amniotic vertebrates (...).[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001466 - VHOG - DOI:10.1046/j.1525-142x.2000.00076.x - http://bgee.unil.ch/ + VHOG + + @@ -252121,7 +66540,7 @@ The modern definition of neurosecretion has evolved to include the release of an pyloric valve - Wikipedia:Pylorus + @@ -252160,13 +66579,14 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a small intestine [Automatically generated definition]. + + BTO:0001259 CALOHA:TS-0941 EMAPA:35780 FMA:14933 MA:0002686 NCIT:C33568 - SCTID:362144000 UMLS:C0227261 mucosa of organ of small bowel mucosa of organ of small intestine @@ -252194,7 +66614,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a small intestine [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -252206,80 +66626,80 @@ The modern definition of neurosecretion has evolved to include the release of an mucosa of organ of small bowel - OBOL:automatic + OBOL:automatic mucosa of organ of small intestine - OBOL:automatic + OBOL:automatic mucosa of small bowel - OBOL:automatic + OBOL:automatic mucous membrane of small bowel - OBOL:automatic + OBOL:automatic organ mucosa of small bowel - OBOL:automatic + OBOL:automatic organ mucosa of small intestine - OBOL:automatic + OBOL:automatic small bowel mucosa - OBOL:automatic + OBOL:automatic small bowel mucosa of organ - OBOL:automatic + OBOL:automatic small bowel mucous membrane - OBOL:automatic + OBOL:automatic small bowel organ mucosa - OBOL:automatic + OBOL:automatic small intestine mucosa of organ - OBOL:automatic + OBOL:automatic small intestine organ mucosa - OBOL:automatic + OBOL:automatic tunica mucosa intestini tenuis FMA:14933 - FMA:TA + FMA:TA @@ -252313,14 +66733,15 @@ The modern definition of neurosecretion has evolved to include the release of an Submucosal tissue in the small intestines. + + + BTO:0002112 EMAPA:37564 FMA:14934 MA:0001562 NCIT:C33572 - SCTID:691000 UMLS:C0227268 - Wikipedia:Small_intestinal_submucosa small bowel submucosa small intestinal submucosa small intestine submucosa @@ -252336,13 +66757,13 @@ The modern definition of neurosecretion has evolved to include the release of an Submucosal tissue in the small intestines. - Wikipedia:Small_intestinal_submucosa + EMAPA:37564 - MA:th + MA:th @@ -252354,13 +66775,13 @@ The modern definition of neurosecretion has evolved to include the release of an small bowel submucosa - OBOL:automatic + OBOL:automatic submucosa of small bowel - OBOL:automatic + OBOL:automatic @@ -252407,10 +66828,10 @@ The modern definition of neurosecretion has evolved to include the release of an A serous membrane that is part of a small intestine [Automatically generated definition]. duodenum, 1st part serosa, 2nd - 4th adventitia + EMAPA:37561 FMA:14938 MA:0001558 - SCTID:8266009 serosa of small bowel serous coat of small intestine serous membrane of small bowel @@ -252431,56 +66852,56 @@ The modern definition of neurosecretion has evolved to include the release of an A serous membrane that is part of a small intestine [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37561 - MA:th + MA:th serosa of small bowel - OBOL:automatic + OBOL:automatic serous membrane of small bowel - OBOL:automatic + OBOL:automatic serous membrane of small intestine - OBOL:automatic + OBOL:automatic small bowel serosa - OBOL:automatic + OBOL:automatic small bowel serous membrane - OBOL:automatic + OBOL:automatic small intestine serous membrane - OBOL:automatic + OBOL:automatic tunica serosa intestini tenuis FMA:14938 - FMA:TA + FMA:TA @@ -252520,6 +66941,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a large intestine [Automatically generated definition]. + CALOHA:TS-2106 EMAPA:35467 FMA:14969 @@ -252543,7 +66965,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a large intestine [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -252555,38 +66977,38 @@ The modern definition of neurosecretion has evolved to include the release of an large intestine mucosa of organ - OBOL:automatic + OBOL:automatic large intestine mucous membrane - OBOL:automatic + OBOL:automatic large intestine organ mucosa - OBOL:automatic + OBOL:automatic mucosa of organ of large intestine - OBOL:automatic + OBOL:automatic organ mucosa of large intestine - OBOL:automatic + OBOL:automatic tunica mucosa intestini crassi FMA:14969 - FMA:TA + FMA:TA @@ -252620,6 +67042,7 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a large intestine [Automatically generated definition]. + BTO:0002111 EMAPA:37560 FMA:14970 @@ -252638,13 +67061,13 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a large intestine [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37560 - MA:th + MA:th @@ -252657,7 +67080,7 @@ The modern definition of neurosecretion has evolved to include the release of an tela submucosa intestini crassi FMA:14970 - FMA:TA + FMA:TA @@ -252704,6 +67127,7 @@ The modern definition of neurosecretion has evolved to include the release of an A serous membrane that is part of a large intestine [Automatically generated definition]. TODO - check serosa/peritoneum + EMAPA:37557 FMA:14975 MA:0001546 @@ -252724,13 +67148,13 @@ The modern definition of neurosecretion has evolved to include the release of an A serous membrane that is part of a large intestine [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37557 - MA:th + MA:th @@ -252742,20 +67166,20 @@ The modern definition of neurosecretion has evolved to include the release of an large intestine serous membrane - OBOL:automatic + OBOL:automatic serous membrane of large intestine - OBOL:automatic + OBOL:automatic tunica serosa intestini crassi FMA:14975 - FMA:TA + FMA:TA @@ -252811,6 +67235,9 @@ The modern definition of neurosecretion has evolved to include the release of an A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP]. currently defined as equivalent to any submucosal gland in the duodenum. Said to be absent outside mammlian (Andrew 1959) but Ziswiler and Farner (1972) noted similar glands at the gastroduodenal junction of some birds + + + BTO:0002376 EMAPA:36522 FMA:15060 @@ -252818,9 +67245,7 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001551 MESH:D002011 NCIT:C13010 - SCTID:41298001 UMLS:C0006323 - Wikipedia:Brunner's_glands Brunner's gland gland of Brunner submucosal gland of duodenum @@ -252837,7 +67262,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MP + MP @@ -252883,7 +67308,7 @@ The modern definition of neurosecretion has evolved to include the release of an A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP]. - Wikipedia:Brunner's_glands + @@ -252929,7 +67354,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -252960,15 +67385,16 @@ The modern definition of neurosecretion has evolved to include the release of an The entire digestive tract is lined by well developed villi, which are longest in the intestinal bulb and decrease progressively in size towards the caudal end of the intestine. No crypts are present, but, the regions between the villi, the intervillus pockets, have a crypt-like function. Cells are produced in the intervillus pockets and shed from the villus tips. Crosnier et al. 2005[TAO] the BTO class refers to a generic villous UBERON:0007607 + + + BTO:0003121 EMAPA:35784 FMA:15072 MA:0001563 NCIT:C33874 - SCTID:23230007 TAO:0005125 UMLS:C1519988 - Wikipedia:Intestinal_villus ZFA:0005125 enteric villi enteric villous @@ -252986,13 +67412,13 @@ The modern definition of neurosecretion has evolved to include the release of an intestinal villus - http://upload.wikimedia.org/wikipedia/commons/3/38/Small_intestine_low_mag.jpg + http://upload.wikimedia.org/wikipedia/commons/3/38/Small_intestine_low_mag.jpg - FMA + FMA @@ -253003,13 +67429,13 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold. - MGI:csmith + MGI:csmith MGI:rbabiuk MP:0008108 @@ -253017,16 +67443,16 @@ The modern definition of neurosecretion has evolved to include the release of an The entire digestive tract is lined by well developed villi, which are longest in the intestinal bulb and decrease progressively in size towards the caudal end of the intestine. No crypts are present, but, the regions between the villi, the intervillus pockets, have a crypt-like function. Cells are produced in the intervillus pockets and shed from the villus tips. Crosnier et al. 2005[TAO] - 2012-08-14 + 2012-08-14 TAO:0005125 - TAO - ZFIN:curator + TAO + ZFIN:curator the BTO class refers to a generic villous - BTO + BTO @@ -253039,7 +67465,7 @@ The modern definition of neurosecretion has evolved to include the release of an enteric villi HP:0011473 - + @@ -253058,13 +67484,13 @@ The modern definition of neurosecretion has evolved to include the release of an intestinal villi ZFA:0005125 - + villi intestinales - + @@ -253088,7 +67514,7 @@ The modern definition of neurosecretion has evolved to include the release of an villi intestinales - Wikipedia:Intestinal_villus + @@ -253123,6 +67549,9 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]. + + + BTO:0002782 EHDAA2:0000819 EHDAA:8712 @@ -253130,10 +67559,9 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:15391 MA:0002178 NCIT:C32782 - SCTID:281055007 + OpenCyc:Mx4rvcV53ZwpEbGdrcN5Y29ycA UMLS:C0226754 VHOG:0001118 - Wikipedia:Inferior_mesenteric_vein uberon lower mesenteric vein vena mesenterica inferior @@ -253141,8 +67569,7 @@ The modern definition of neurosecretion has evolved to include the release of an inferior mesenteric vein - http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb + http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png @@ -253153,13 +67580,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA/obol + FMA/obol A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]. - Wikipedia:Inferior_mesenteric_vein + @@ -253177,7 +67604,7 @@ The modern definition of neurosecretion has evolved to include the release of an vena mesenterica inferior - Wikipedia:Inferior_mesenteric_vein + @@ -253217,11 +67644,12 @@ The modern definition of neurosecretion has evolved to include the release of an Lamina propria that is part_of the small intestine. + + EMAPA:35779 FMA:15651 MA:0001554 NCIT:C49297 - SCTID:63588008 UMLS:C1711325 lamina propria mucosa of small bowel lamina propria mucosa of small intestine @@ -253248,7 +67676,7 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + @@ -253266,55 +67694,55 @@ The modern definition of neurosecretion has evolved to include the release of an lamina propria mucosa of small bowel - OBOL:automatic + OBOL:automatic lamina propria mucosa of small intestine - OBOL:automatic + OBOL:automatic lamina propria mucosae of small bowel - OBOL:automatic + OBOL:automatic lamina propria of small bowel - OBOL:automatic + OBOL:automatic small bowel lamina propria - OBOL:automatic + OBOL:automatic small bowel lamina propria mucosa - OBOL:automatic + OBOL:automatic small bowel lamina propria mucosae - OBOL:automatic + OBOL:automatic small intestine lamina propria mucosa - OBOL:automatic + OBOL:automatic small intestine lamina propria mucosae - OBOL:automatic + OBOL:automatic @@ -253347,6 +67775,8 @@ The modern definition of neurosecretion has evolved to include the release of an Mucosal layer that lines the intestine. + + BTO:0000642 EMAPA:35440 FMA:15695 @@ -253354,7 +67784,6 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001537 MESH:D007413 NCIT:C49241 - SCTID:362080002 UMLS:C0021839 bowel mucosa bowel mucosa of organ @@ -253383,7 +67812,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mucosal layer that lines the intestine. - UBERON:cjm + UBERON:cjm @@ -253395,85 +67824,85 @@ The modern definition of neurosecretion has evolved to include the release of an bowel mucosa - OBOL:automatic + OBOL:automatic bowel mucosa of organ - OBOL:automatic + OBOL:automatic bowel mucous membrane - OBOL:automatic + OBOL:automatic bowel organ mucosa - OBOL:automatic + OBOL:automatic intestine mucosa of organ - OBOL:automatic + OBOL:automatic intestine mucous membrane - OBOL:automatic + OBOL:automatic intestine organ mucosa - OBOL:automatic + OBOL:automatic mucosa of bowel - OBOL:automatic + OBOL:automatic mucosa of organ of bowel - OBOL:automatic + OBOL:automatic mucosa of organ of intestine - OBOL:automatic + OBOL:automatic mucous membrane of bowel - OBOL:automatic + OBOL:automatic mucous membrane of intestine - OBOL:automatic + OBOL:automatic organ mucosa of bowel - OBOL:automatic + OBOL:automatic organ mucosa of intestine - OBOL:automatic + OBOL:automatic @@ -253557,229 +67986,229 @@ The modern definition of neurosecretion has evolved to include the release of an A serous membrane that is part of a wall of intestine [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37619 - MA:th + MA:th anatomical wall of bowel serosa - OBOL:automatic + OBOL:automatic anatomical wall of bowel serous membrane - OBOL:automatic + OBOL:automatic anatomical wall of intestine serosa - OBOL:automatic + OBOL:automatic anatomical wall of intestine serous membrane - OBOL:automatic + OBOL:automatic bowel anatomical wall serosa - OBOL:automatic + OBOL:automatic bowel anatomical wall serous membrane - OBOL:automatic + OBOL:automatic bowel wall serosa - OBOL:automatic + OBOL:automatic bowel wall serous membrane - OBOL:automatic + OBOL:automatic intestinal wall serosa - OBOL:automatic + OBOL:automatic intestinal wall serous membrane - OBOL:automatic + OBOL:automatic intestine anatomical wall serosa - OBOL:automatic + OBOL:automatic intestine anatomical wall serous membrane - OBOL:automatic + OBOL:automatic intestine wall serosa - OBOL:automatic + OBOL:automatic intestine wall serous membrane - OBOL:automatic + OBOL:automatic serosa of anatomical wall of bowel - OBOL:automatic + OBOL:automatic serosa of anatomical wall of intestine - OBOL:automatic + OBOL:automatic serosa of bowel anatomical wall - OBOL:automatic + OBOL:automatic serosa of bowel wall - OBOL:automatic + OBOL:automatic serosa of intestinal wall - OBOL:automatic + OBOL:automatic serosa of intestine anatomical wall - OBOL:automatic + OBOL:automatic serosa of intestine wall - OBOL:automatic + OBOL:automatic serosa of wall of bowel - OBOL:automatic + OBOL:automatic serosa of wall of intestine - OBOL:automatic + OBOL:automatic serous membrane of anatomical wall of bowel - OBOL:automatic + OBOL:automatic serous membrane of anatomical wall of intestine - OBOL:automatic + OBOL:automatic serous membrane of bowel anatomical wall - OBOL:automatic + OBOL:automatic serous membrane of bowel wall - OBOL:automatic + OBOL:automatic serous membrane of intestinal wall - OBOL:automatic + OBOL:automatic serous membrane of intestine anatomical wall - OBOL:automatic + OBOL:automatic serous membrane of intestine wall - OBOL:automatic + OBOL:automatic serous membrane of wall of bowel - OBOL:automatic + OBOL:automatic serous membrane of wall of intestine - OBOL:automatic + OBOL:automatic wall of bowel serosa - OBOL:automatic + OBOL:automatic wall of bowel serous membrane - OBOL:automatic + OBOL:automatic wall of intestine serosa - OBOL:automatic + OBOL:automatic wall of intestine serous membrane - OBOL:automatic + OBOL:automatic @@ -253822,6 +68251,9 @@ The modern definition of neurosecretion has evolved to include the release of an anal In the lungfish, sharks and rays the rectum opens into the cloaca which also receives wastes (urine) from the kidneys and material from the reproductive organs. In bony fish the rectum reaches the outside environment through the anus, which is normally situated just in front the urinary and reproductive openings. However in some fish the digestive tract may be curled back on itself, and in the Electric Eel (Electrophorus electricus) the anus is situated in the fish's throat. -- http://www.earthlife.net/fish/digestion.html + + + BTO:0001680 CALOHA:TS-2005 EV:0100082 @@ -253830,12 +68262,11 @@ The modern definition of neurosecretion has evolved to include the release of an GAID:312 MA:0000331 NCIT:C43362 - SCTID:181262009 + OpenCyc:Mx4rvVjaEZwpEbGdrcN5Y29ycA TADS:0000066 TGMA:0001279 UMLS:C0003461 WBbt:0005364 - Wikipedia:Anus galen:Anus anal opening anal orifice @@ -253847,15 +68278,15 @@ The modern definition of neurosecretion has evolved to include the release of an anus - http://upload.wikimedia.org/wikipedia/commons/6/65/Protovsdeuterostomes.svg - http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif + http://upload.wikimedia.org/wikipedia/commons/6/65/Protovsdeuterostomes.svg + http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts. - Wikipedia:Anus - ZFIN:curator + + ZFIN:curator @@ -253895,12 +68326,13 @@ The modern definition of neurosecretion has evolved to include the release of an The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad. + + + FMA:15767 MA:0002668 NCIT:C32827 - SCTID:83488001 UMLS:C0227515 - Wikipedia:Interlobular_bile_ducts interlobular ductule uberon UBERON:0001246 @@ -253911,7 +68343,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA MA-part-of @@ -253923,9 +68355,9 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA - MA - MP + FMA + MA + MP @@ -253971,6 +68403,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical wall that is part of a intestine [Automatically generated definition]. we place two MA classes here due to the official ncit2ma mapping to intestinal wall tissue; not clear how bowel and intestine are different + BTO:0000647 EMAPA:35444 FMA:15949 @@ -253995,7 +68428,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical wall that is part of a intestine [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -254007,37 +68440,37 @@ The modern definition of neurosecretion has evolved to include the release of an anatomical wall of bowel - OBOL:automatic + OBOL:automatic anatomical wall of intestine - OBOL:automatic + OBOL:automatic bowel anatomical wall - OBOL:automatic + OBOL:automatic bowel wall - OBOL:automatic + OBOL:automatic intestine anatomical wall - OBOL:automatic + OBOL:automatic wall of bowel - OBOL:automatic + OBOL:automatic @@ -254090,11 +68523,12 @@ The modern definition of neurosecretion has evolved to include the release of an The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct. + + EMAPA:35651 FMA:16011 MA:0002417 NCIT:C49268 - SCTID:247604006 UMLS:C0227578 acinus pancreaticus pancreas acinus @@ -254115,7 +68549,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -254140,7 +68574,7 @@ The modern definition of neurosecretion has evolved to include the release of an pancreatic acini - + @@ -254148,6 +68582,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -254193,6 +68628,9 @@ The modern definition of neurosecretion has evolved to include the release of an As a secretory organ serving exocrine and endocrine functions, the pancreas is specific to the vertebrates[PMID:16417468] Hagfishes and lampreys are unique in the complete separation of their endocrine pancreas (islet or- gan) and their exocrine pancreas (50). The endocrine and exocrine pancreas are coassociated in crown gnathostomes (50). In Branchiostoma and Ciona, there is no diverticulum as there is in hagfishes, lampreys, and gnathostomes, only dispersed insulin-secreting cells in the walls of the gastrointestinal tract (51, 52) The zebrafish does not have a discrete pancreas. Exocrine pancreatic tissue can be found scattered along the intestinal tract. The acinar structure of the exocrine pancreas is very similar to that of mammals and comprises cells with a very dark, basophilic cytoplasm The mature pancreas of higher vertebrates and mammals comprises two major functional units: the exocrine pancreas, which is responsible for the production of digestive enzymes to be secreted into the gut lumen, and the endocrine pancreas, which has its role in the synthesis of several hormones with key regulatory functions in food uptake and metabolism. The exocrine portion constitutes the majority of the mass of the pancreas, and contains only two different cell types, the secretory acinar cells and the ductular cells. The endocrine portion, which comprises only 1-2% of the total mass, contains five different cell types, which are organized into mixed functional assemblies referred to as the islets of Langerhans + + + AAO:0010112 BTO:0000988 CALOHA:TS-0736 @@ -254208,11 +68646,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D010179 MIAA:0000075 NCIT:C12393 - SCTID:181277001 + OpenCyc:Mx4rvVimZZwpEbGdrcN5Y29ycA TAO:0000140 UMLS:C0030274 VHOG:0000050 - Wikipedia:Pancreas XAO:0000136 ZFA:0000140 galen:Pancreas @@ -254226,9 +68663,7 @@ The modern definition of neurosecretion has evolved to include the release of an pancreas - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Pancreas.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Pancreas.glb - https://upload.wikimedia.org/wikipedia/commons/7/7e/Blausen_0699_PancreasAnatomy2.png + https://upload.wikimedia.org/wikipedia/commons/7/7e/Blausen_0699_PancreasAnatomy2.png @@ -254239,7 +68674,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:16417468 + @@ -254250,7 +68685,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia @@ -254261,7 +68696,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia @@ -254273,32 +68708,32 @@ The modern definition of neurosecretion has evolved to include the release of an Organ which secretes a fluid containing enzymes that aid in the digestion of food.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010112 - AAO - AAO:BJB + AAO + AAO:BJB In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000050 - VHOG + VHOG + DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007) - http://bgee.unil.ch/ As a secretory organ serving exocrine and endocrine functions, the pancreas is specific to the vertebrates[PMID:16417468] Hagfishes and lampreys are unique in the complete separation of their endocrine pancreas (islet or- gan) and their exocrine pancreas (50). The endocrine and exocrine pancreas are coassociated in crown gnathostomes (50). In Branchiostoma and Ciona, there is no diverticulum as there is in hagfishes, lampreys, and gnathostomes, only dispersed insulin-secreting cells in the walls of the gastrointestinal tract (51, 52) - PMID:20959416 + The mature pancreas of higher vertebrates and mammals comprises two major functional units: the exocrine pancreas, which is responsible for the production of digestive enzymes to be secreted into the gut lumen, and the endocrine pancreas, which has its role in the synthesis of several hormones with key regulatory functions in food uptake and metabolism. The exocrine portion constitutes the majority of the mass of the pancreas, and contains only two different cell types, the secretory acinar cells and the ductular cells. The endocrine portion, which comprises only 1-2% of the total mass, contains five different cell types, which are organized into mixed functional assemblies referred to as the islets of Langerhans - PMID:16417468 + @@ -254339,13 +68774,14 @@ The modern definition of neurosecretion has evolved to include the release of an A trabecula that is part of a spleen. + + + EMAPA:35808 FMA:16027 MA:0000758 NCIT:C33607 - SCTID:61987002 UMLS:C0229688 - Wikipedia:Trabeculae_of_spleen spleen trabeculum splenic trabecula trabeculae of spleen @@ -254363,13 +68799,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A trabecula that is part of a spleen. - OBOL:automatic + OBOL:automatic @@ -254381,7 +68817,7 @@ The modern definition of neurosecretion has evolved to include the release of an trabeculae of spleen - + @@ -254410,11 +68846,11 @@ The modern definition of neurosecretion has evolved to include the release of an Transudate contained in the peritoneal cavity. + BTO:0001031 EMAPA:35683 FMA:16515 MA:0002531 - Wikipedia:Peritoneal_fluid ncithesaurus:Peritoneal_Fluid uberon UBERON:0001268 @@ -254426,7 +68862,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -254451,6 +68887,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -254481,10 +68918,11 @@ The modern definition of neurosecretion has evolved to include the release of an The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pelvic girdle regions. this class describes the subdivision of the limb/fin, NOT the skeleton within. See also: skeleton of pectoral girdle (UBERON:0007831). See also comments on obo-anatomy mail list. Note that even though the class includes soft tissue it is more restrictive than 'pelvis' which also includes structures in cavities etc. TODO this needs to be better documented Subdivision of lower limb or fin which links the limb/fin to the body[FMA,modified]. There is only one instance of the pelvic girdle region per organism.[VSAO] + + EMAPA:37862 FMA:16581 NCIT:C33291 - SCTID:360010001 UMLS:C0684083 VSAO:0000304 uberon @@ -254499,27 +68937,27 @@ The modern definition of neurosecretion has evolved to include the release of an The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pelvic girdle regions. - DOI:10.1002/dvdy.22617 + + + FMA:16581 FMA:23217 - UBERONREF:0000003 - https://groups.google.com/d/topic/obo-anatomy/h4R4xKmINrw/discussion - https://orcid.org/0000-0002-6601-2165 + UBERONREF:0000003 Subdivision of lower limb or fin which links the limb/fin to the body[FMA,modified]. There is only one instance of the pelvic girdle region per organism.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000304 - VSAO - https://orcid.org/0000-0002-6601-2165 + VSAO + EMAPA:37862 - MA:th + MA:th @@ -254574,13 +69012,13 @@ The modern definition of neurosecretion has evolved to include the release of an The epithelial layer of the stomach . in FMA this is classified as simple columnar, MA divides this into squamous and glandular + BTO:0000500 CALOHA:TS-2068 EHDAA2:0001918 EMAPA:17023 FMA:17091 MA:0001610 - SCTID:64977002 VHOG:0001433 epithelial tissue of stomach epithelial tissue of ventriculus @@ -254605,49 +69043,49 @@ The modern definition of neurosecretion has evolved to include the release of an in FMA this is classified as simple columnar, MA divides this into squamous and glandular - FMA + FMA epithelial tissue of stomach - OBOL:automatic + OBOL:automatic epithelial tissue of ventriculus - OBOL:automatic + OBOL:automatic epithelium of ventriculus - OBOL:automatic + OBOL:automatic stomach epithelial tissue - OBOL:automatic + OBOL:automatic stomach epithelium - OBOL:automatic + OBOL:automatic ventriculus epithelial tissue - OBOL:automatic + OBOL:automatic ventriculus epithelium - OBOL:automatic + OBOL:automatic @@ -254696,15 +69134,16 @@ The modern definition of neurosecretion has evolved to include the release of an Epithelial layer that lines the intestine. Simple columnar epithelium that lines the intestine, sometimes pseudostratified, with absorptive brush-border cells and mucous goblet cells clearly visible. Crosnier et al. 2005[TAO] + + + BTO:0000781 EMAPA:32873 FMA:17229 MA:0001536 NCIT:C49240 - SCTID:266135004 TAO:0005124 UMLS:C0226890 - Wikipedia:Intestinal_epithelium ZFA:0005124 bowel epithelial tissue bowel epithelium @@ -254726,16 +69165,16 @@ The modern definition of neurosecretion has evolved to include the release of an Epithelial layer that lines the intestine. - UBERON:cjm + UBERON:cjm Simple columnar epithelium that lines the intestine, sometimes pseudostratified, with absorptive brush-border cells and mucous goblet cells clearly visible. Crosnier et al. 2005[TAO] - 2012-08-14 + 2012-08-14 TAO:0005124 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -254747,43 +69186,43 @@ The modern definition of neurosecretion has evolved to include the release of an bowel epithelial tissue - OBOL:automatic + OBOL:automatic bowel epithelium - OBOL:automatic + OBOL:automatic epithelial tissue of bowel - OBOL:automatic + OBOL:automatic epithelial tissue of intestine - OBOL:automatic + OBOL:automatic epithelium of bowel - OBOL:automatic + OBOL:automatic epithelium of intestine - OBOL:automatic + OBOL:automatic intestine epithelial tissue - OBOL:automatic + OBOL:automatic @@ -254838,19 +69277,19 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a large intestine [Automatically generated definition]. - OBOL:automatic + OBOL:automatic epithelial tissue of large intestine - OBOL:automatic + OBOL:automatic large intestine epithelial tissue - OBOL:automatic + OBOL:automatic @@ -254858,7 +69297,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -254894,12 +69332,13 @@ The modern definition of neurosecretion has evolved to include the release of an A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel. The misnomer 'portal triad' traditionally has included only the first three structures, and was named before lymphatic vessels were discovered in the structure. It can refer both to the largest branch of each of these vessels running inside the hepatoduodenal ligament, and to the smaller branches of these vessels inside the liver. + + + FMA:17523 MA:0002499 NCIT:C33342 - SCTID:362192000 UMLS:C0227514 - Wikipedia:Portal_triad trias hepatica uberon trias hepatica @@ -254908,16 +69347,16 @@ The modern definition of neurosecretion has evolved to include the release of an portal triad - https://upload.wikimedia.org/wikipedia/commons/6/62/Portal_triad.JPG + https://upload.wikimedia.org/wikipedia/commons/6/62/Portal_triad.JPG A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel. - ISBN:0-683-40008-8 - MGI:csmith + + ISBN:0-683-40008-8 + MGI:csmith MP:0008993 - http://orcid.org/0000-0002-6601-2165 @@ -254929,7 +69368,7 @@ The modern definition of neurosecretion has evolved to include the release of an trias hepatica - Wikipedia:Portal_triad + @@ -254972,6 +69411,8 @@ The modern definition of neurosecretion has evolved to include the release of an The functional units of the liver including the lobules. the (liver) tubular structure (dual layered parenchyma) appears to be conserved among all embryonic vertebrates (...) it is not unlikely that all vertebrate livers share the same fundamental functional unit.[well established][VHOG] UBERON:0003223 + + AAO:0010405 EHDAA2:0001004 EHDAA:2201 @@ -254979,8 +69420,6 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:17540 MA:0000366 NCIT:C32735 - SCTID:363535004 - UMLS:C0736268 VHOG:0000539 XAO:0000454 hepatic parenchyma @@ -255001,7 +69440,7 @@ The modern definition of neurosecretion has evolved to include the release of an - XAO + XAO @@ -255013,11 +69452,11 @@ The modern definition of neurosecretion has evolved to include the release of an the (liver) tubular structure (dual layered parenchyma) appears to be conserved among all embryonic vertebrates (...) it is not unlikely that all vertebrate livers share the same fundamental functional unit.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000539 - VHOG + VHOG + DOI:10.1002/ar.20524 Hardman RC, Volz DC, Kullman SW, Hinton DE, An in vivo look at vertebrate liver architecture: three-dimensional reconstruction from Medaka (Oryzias latipes). The Anatomical Record (2007) - http://bgee.unil.ch/ @@ -255109,16 +69548,17 @@ The modern definition of neurosecretion has evolved to include the release of an (...) the amphibian liver has characteristics in common with both fish and terrestrial vertebrates. (...) The histological structure of the liver is similar to that in other vertebrates, with hepatocytes arranged in clusters and cords separated by a meshwork of sinusoids and the presence of the traditional triad of portal venule, hepatic arteriole, and bile duct.[well established][VHOG] UBERON:0003275 + + + EHDAA2:0000999 EMAPA:17365 FMA:17543 MA:0000367 NCIT:C32733 - SCTID:67435004 TAO:0005091 UMLS:C0227523 VHOG:0000708 - Wikipedia:Hepatic_sinusoid ZFA:0005091 liver hepatic sinusoids liver sinusoid @@ -255145,24 +69585,24 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers. - Wikipedia:Hepatic_sinusoid - ZFIN:curator + + ZFIN:curator (...) the amphibian liver has characteristics in common with both fish and terrestrial vertebrates. (...) The histological structure of the liver is similar to that in other vertebrates, with hepatocytes arranged in clusters and cords separated by a meshwork of sinusoids and the presence of the traditional triad of portal venule, hepatic arteriole, and bile duct.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000708 - VHOG + VHOG + DOI:10.1053/ax.2000.7133 Crawshaw GJ, Weinkle TK, Clinical and pathological aspects of the amphibian liver. Seminars in Avian and Exotic Pet Medicine (2000) - http://bgee.unil.ch/ @@ -255180,25 +69620,25 @@ The modern definition of neurosecretion has evolved to include the release of an liver sinusoidal blood vessel - OBOL:automatic + OBOL:automatic sinusoid of liver - OBOL:automatic + OBOL:automatic sinusoidal blood vessel of liver - OBOL:automatic + OBOL:automatic vas sinusoideum - Wikipedia:Hepatic_sinusoid + @@ -255242,13 +69682,14 @@ The modern definition of neurosecretion has evolved to include the release of an The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule. Note that this is part of the intrahepatic bile duct in MA, as this class is more alike the tree in FMA. Note also that SCT has canal of Hering and Entire IBduct as the only sibling terms under 'Structure of intralobular bile duct' (i.e. the CoH is the only part of the entire IBduct) + + + + FMA:17545 MA:0002669 NCIT:C32255 - SCTID:227002 - SCTID:269922006 UMLS:C0227517 - Wikipedia:Canals_of_Hering canal of Herring cholangiole ductus interlobularis bilifer @@ -255267,7 +69708,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -255278,7 +69719,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -255289,13 +69730,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule. - MGI:csmith + MGI:csmith MP:0009499 @@ -255321,27 +69762,27 @@ The modern definition of neurosecretion has evolved to include the release of an ductus interlobularis bilifer FMA:17545 - FMA:TA + FMA:TA canals of Hering - Wikipedia:Canals_of_Hering - + + duct of Herring - Wikipedia:Canals_of_Hering + intrahepatic bile ductule - Wikipedia:Canals_of_Hering + @@ -255403,7 +69844,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -255415,13 +69856,13 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37481 - MA:th + MA:th muscle organ of pelvis - OBOL:automatic + OBOL:automatic @@ -255433,7 +69874,7 @@ The modern definition of neurosecretion has evolved to include the release of an pelvis muscle organ - OBOL:automatic + OBOL:automatic @@ -255442,6 +69883,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -255456,6 +69898,8 @@ The modern definition of neurosecretion has evolved to include the release of an The anus and surrounding regions. Encompasses both internal and external regions, where present. Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG] + + EFO:0000847 EHDAA2:0000122 EHDAA:2931 @@ -255464,7 +69908,6 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000042 MIAA:0000042 NCIT:C32069 - SCTID:362680001 UMLS:C0230120 VHOG:0000395 WBbt:0006919 @@ -255477,7 +69920,7 @@ The modern definition of neurosecretion has evolved to include the release of an anal region https://github.com/obophenotype/uberon/issues/507 - http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray408.png + http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray408.png @@ -255494,17 +69937,17 @@ The modern definition of neurosecretion has evolved to include the release of an The anus and surrounding regions. Encompasses both internal and external regions, where present. - https://orcid.org/0000-0002-6601-2165 + Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000395 - VHOG + VHOG + ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11 - http://bgee.unil.ch/ @@ -255551,13 +69994,13 @@ The modern definition of neurosecretion has evolved to include the release of an The outer layer of peritoneum that is attached to the abdominal and pelvic walls. Peritoneum attached to the abdominal wall.[AAO] UBERON:0004459 + + AAO:0010816 EMAPA:16591 FMA:21451 - SCTID:362700006 TAO:0005131 VHOG:0001527 - Wikipedia:Parietal_peritoneum ZFA:0005131 parietal serous membrane of peritoneum uberon @@ -255566,29 +70009,29 @@ The modern definition of neurosecretion has evolved to include the release of an parietal peritoneum - http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png + http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png The outer layer of peritoneum that is attached to the abdominal and pelvic walls. - Wikipedia:Peritoneum#Types - http://orcid.org/0000-0002-6601-2165 + + Peritoneum attached to the abdominal wall.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010816 - AAO + AAO AAO:JMG parietal serous membrane of peritoneum - UBERON:cjm + UBERON:cjm @@ -255615,10 +70058,10 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a pelvis [Automatically generated definition]. + EMAPA:37282 FMA:22984 MA:0000546 - SCTID:181517009 pelvic skin pelvis skin pelvis zone of skin @@ -255631,25 +70074,25 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a pelvis [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37282 - MA:th + MA:th pelvis zone of skin - OBOL:automatic + OBOL:automatic zone of skin of pelvis - OBOL:automatic + OBOL:automatic @@ -255676,12 +70119,13 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of an abdomen [Automatically generated definition]. + + EFO:0000214 FMA:22988 FMA:23000 MA:0000523 NCIT:C52758 - SCTID:361707007 UMLS:C0222166 abdomen skin abdomen zone of skin @@ -255698,7 +70142,7 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of an abdomen [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -255710,7 +70154,7 @@ The modern definition of neurosecretion has evolved to include the release of an abdomen zone of skin - OBOL:automatic + OBOL:automatic @@ -255722,7 +70166,7 @@ The modern definition of neurosecretion has evolved to include the release of an zone of skin of abdomen - OBOL:automatic + OBOL:automatic @@ -255741,7 +70185,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -255749,12 +70193,13 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a neck [Automatically generated definition]. + + EMAPA:37277 FMA:23021 FMA:23022 MA:0000590 NCIT:C52756 - SCTID:361705004 UMLS:C0205030 neck (volume) zone of skin neck skin @@ -255769,13 +70214,13 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a neck [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37277 - MA:th + MA:th @@ -255787,25 +70232,25 @@ The modern definition of neurosecretion has evolved to include the release of an neck (volume) zone of skin - OBOL:automatic + OBOL:automatic neck zone of skin - OBOL:automatic + OBOL:automatic zone of skin of neck - OBOL:automatic + OBOL:automatic zone of skin of neck (volume) - OBOL:automatic + OBOL:automatic @@ -255832,11 +70277,11 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a thorax [Automatically generated definition]. + EMAPA:37765 FMA:23028 FMA:23029 MA:0000564 - SCTID:281723000 thoracic skin thorax skin thorax zone of skin @@ -255850,25 +70295,25 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a thorax [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37765 - MA:th + MA:th thorax zone of skin - OBOL:automatic + OBOL:automatic zone of skin of thorax - OBOL:automatic + OBOL:automatic @@ -255913,9 +70358,9 @@ The modern definition of neurosecretion has evolved to include the release of an An organism subdivision that includes the pectoral girdle skeleton. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). There is only one instance of the pectoral girdle region per organism.[VSAO] Note that this class describes the central subdivision of the pectoral girdle complex, NOT the skeleton within.[VSAO] + EMAPA:37856 FMA:23217 - SCTID:229759004 VSAO:0000305 galen:ShoulderGirdle cingulum membri superioris @@ -255936,47 +70381,47 @@ The modern definition of neurosecretion has evolved to include the release of an An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions. + FMA:23217 - UBERONREF:0000003 - https://orcid.org/0000-0002-6601-2165 + UBERONREF:0000003 An organism subdivision that includes the pectoral girdle skeleton. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). There is only one instance of the pectoral girdle region per organism.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000305 - VSAO - https://orcid.org/0000-0002-6601-2165 + VSAO + Note that this class describes the central subdivision of the pectoral girdle complex, NOT the skeleton within.[VSAO] - 2012-09-06 + 2012-09-06 VSAO:0000305 - VSAO - Curator + VSAO + Curator EMAPA:37856 - MA:th + MA:th cingulum membri superioris FMA:23217 - FMA:TA + FMA:TA cingulum membri superioris - FMA:TA + FMA:TA @@ -256054,6 +70499,7 @@ The modern definition of neurosecretion has evolved to include the release of an By taking a holistic approach, integration of the evidence from molecular and developmental features of model organisms, the phylogenetic distribution in the 'new animal phylogeny' and the earliest fossilized remains of mineralized animal skeletons suggests independent origins of the skeleton at the phylum level.[debated][VHOG] skeletal GO defines skeletal system very generically: The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) GO:0001501; however, all annotations are to vertebrates + AAO:0000566 BTO:0001486 CALOHA:TS-1320 @@ -256063,6 +70509,7 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:23881 MA:0000018 NCIT:C12788 + OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA TAO:0000434 UMLS:C0037253 VHOG:0001254 @@ -256085,47 +70532,47 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system. - GO_REF:0000034 + + GO_REF:0000034 VSAO:0000027 - http://dx.plos.org/10.1371/journal.pone.0051070 Anatomical system consisting of multiple elements and tissues that provides physical support.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000434 - TAO - TAO:wd + TAO + TAO:wd Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000027 - VSAO + VSAO GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 - PSPUB:0000170 + PSPUB:0000170 System that provides physical support to the organism.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000566 - AAO - AAO:LAP + AAO + AAO:LAP By taking a holistic approach, integration of the evidence from molecular and developmental features of model organisms, the phylogenetic distribution in the 'new animal phylogeny' and the earliest fossilized remains of mineralized animal skeletons suggests independent origins of the skeleton at the phylum level.[debated][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001254 - VHOG + VHOG + DOI:10.1159/000324245 Donoghue PCJ, Sansom IJ, Origin and early evolution of vertebrate skeletonization. Microscopy research and technique (2002) - http://bgee.unil.ch/ @@ -256164,8 +70611,8 @@ The modern definition of neurosecretion has evolved to include the release of an + FMA:24218 - SCTID:123852005 XAO:0000040 head subdivision uberon @@ -256181,6 +70628,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -256199,6 +70647,9 @@ The modern definition of neurosecretion has evolved to include the release of an The area that extends from the median ocellus to the oral foramen[HAO]. facial The face develops from outward growth of tissue located rostral to the cranium & pharynx. The lower jaw and most of the upper jaw are formed by growth of the first pharyngeal (branchial) arch. The upper incisor region and the nose and forehead (frontal region) are formed from tissue located rostral to the neural tube (frontonasal prominence) + + + BTO:0003369 CALOHA:TS-2216 EMAPA:32763 @@ -256208,9 +70659,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002473 MESH:D005145 NCIT:C13071 - SCTID:302549007 + OpenCyc:Mx4rvVi5GZwpEbGdrcN5Y29ycA UMLS:C0015450 - Wikipedia:Face galen:Face uberon facia/facies @@ -256219,13 +70669,13 @@ The modern definition of neurosecretion has evolved to include the release of an face - http://upload.wikimedia.org/wikipedia/commons/5/55/Mona_Lisa_headcrop.jpg + http://upload.wikimedia.org/wikipedia/commons/5/55/Mona_Lisa_headcrop.jpg A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc). - http://orcid.org/0000-0002-6601-2165 + @@ -256237,8 +70687,8 @@ The modern definition of neurosecretion has evolved to include the release of an The area that extends from the median ocellus to the oral foramen[HAO]. + HAO:0000316 - http://api.hymao.org/api/ref/67791 NCBITaxon:7399 @@ -256257,7 +70707,7 @@ The modern definition of neurosecretion has evolved to include the release of an facia/facies - Wikipedia:Face + @@ -256283,7 +70733,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -256291,11 +70741,12 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a lip [Automatically generated definition]. + + EMAPA:37643 FMA:24764 MA:0001579 NCIT:C12291 - SCTID:244092005 UMLS:C0222101 lip skin lip zone of skin @@ -256309,13 +70760,13 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a lip [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37643 - MA:th + MA:th @@ -256327,19 +70778,19 @@ The modern definition of neurosecretion has evolved to include the release of an lip zone of skin - OBOL:automatic + OBOL:automatic zone of skin of lip - OBOL:automatic + OBOL:automatic skin of lips - + @@ -256358,6 +70809,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -256388,6 +70840,9 @@ The modern definition of neurosecretion has evolved to include the release of an Skeletal element that is composed of bone tissue.[VSAO] relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO] The 'new animal phylogeny' reveals that many of the groups known to biomineralize sit among close relatives that do not, and it favours an interpretation of convergent or parallel evolution for biomineralization in animals. (...) Whether this 'biomineralization toolkit'of genes reflects a parallel co-option of a common suite of genes or the inheritance of a skeletogenic gene regulatory network from a biomineralizing common ancestor remains an open debate.[debated][VHOG] + + + AAO:0000047 AEO:0000082 BTO:0000140 @@ -256404,12 +70859,12 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000299 MIAA:0000299 NCIT:C12366 - SCTID:90780006 + OpenCyc:Mx4rvViDlpwpEbGdrcN5Y29ycA + OpenCyc:Mx4rvVkCG5wpEbGdrcN5Y29ycA TAO:0001514 UMLS:C0262950 VHOG:0001190 VSAO:0000057 - Wikipedia:Bone XAO:0000169 ZFA:0001514 galen:Bone @@ -256441,56 +70896,56 @@ The modern definition of neurosecretion has evolved to include the release of an Skeletal element that is composed of bone tissue. - GO_REF:0000034 - PSPUB:0000170 + + + GO_REF:0000034 + PSPUB:0000170 VSAO:0000057 - http://dx.plos.org/10.1371/journal.pone.0051070 - https://github.com/obophenotype/uberon/issues/277 Also called osseous tissue, (Latin: os). Is a type of hard endoskeletal connective tissue found in many vertebrate animals. Bone is the main tissue of body organs that support body structures, protect internal organs, (in conjunction with muscles) facilitate movement; and are involved with cell formation, calcium metabolism, and mineral storage.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000047 - AAO - AAO:LAP + AAO + AAO:LAP Portion of tissue which is calcified connective tissue making up the structural elements of the skeletal system.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001514 - TAO - ZFIN:curator + TAO + ZFIN:curator Skeletal element that is composed of bone tissue.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000057 - VSAO - PSPUB:0000170 + VSAO + PSPUB:0000170 relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO] - 2012-06-20 + 2012-06-20 AAO:0000047 - AAO + AAO The 'new animal phylogeny' reveals that many of the groups known to biomineralize sit among close relatives that do not, and it favours an interpretation of convergent or parallel evolution for biomineralization in animals. (...) Whether this 'biomineralization toolkit'of genes reflects a parallel co-option of a common suite of genes or the inheritance of a skeletogenic gene regulatory network from a biomineralizing common ancestor remains an open debate.[debated][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001190 - VHOG + VHOG + DOI:10.1159/000324245 Murdock DJ, Donoghue PC, Evolutionary Origins of Animal Skeletal Biomineralization. Cells Tissues Organs (2011) - http://bgee.unil.ch/ @@ -256518,7 +70973,7 @@ The modern definition of neurosecretion has evolved to include the release of an bones ZFA:0001514 - + @@ -256542,6 +70997,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -256556,6 +71012,9 @@ The modern definition of neurosecretion has evolved to include the release of an An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]. check ncita + + + EMAPA:37621 FMA:34836 GAID:263 @@ -256563,9 +71022,7 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D017746 NCIT:C32259 NCIT:C84388 - SCTID:182238002 UMLS:C0206207 - Wikipedia:Articular_capsule galen:JointCapsule capsula articularis fibrous capsule of joint @@ -256577,14 +71034,14 @@ The modern definition of neurosecretion has evolved to include the release of an articular capsule - http://upload.wikimedia.org/wikipedia/commons/1/19/Joint.png - http://upload.wikimedia.org/wikipedia/commons/4/4a/Gray299.png + http://upload.wikimedia.org/wikipedia/commons/1/19/Joint.png + http://upload.wikimedia.org/wikipedia/commons/4/4a/Gray299.png An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]. - Wikipedia:Articular_capsule + @@ -256596,7 +71053,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37621 - MA:th + MA:th @@ -256609,14 +71066,14 @@ The modern definition of neurosecretion has evolved to include the release of an capsula articularis FMA:34836 - FMA:TA + FMA:TA capsulae articulares - Wikipedia:Articular_capsule + @@ -256626,6 +71083,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -256658,15 +71116,17 @@ The modern definition of neurosecretion has evolved to include the release of an The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia]. + + + EHDAA2:0000147 EHDAA:9828 EMAPA:17014 FMA:3736 MA:0002570 NCIT:C32150 - SCTID:181299009 + OpenCyc:Mx4rwVFqO5wpEbGdrcN5Y29ycA UMLS:C0003956 - Wikipedia:Ascending_aorta ascending thoracic aorta pars ascendens aortae uberon @@ -256677,9 +71137,7 @@ The modern definition of neurosecretion has evolved to include the release of an ascending aorta - http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb + http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg @@ -256690,14 +71148,14 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia]. + GO:0035905 - Wikipedia:Ascending_aorta @@ -256715,14 +71173,14 @@ The modern definition of neurosecretion has evolved to include the release of an aorta ascendens - Wikipedia:Ascending_aorta + pars ascendens aortae - Wikipedia:Ascending_aorta + @@ -256786,49 +71244,49 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + Any muscle organ that is part of a pelvic girdle [Automatically generated definition]. - OBOL:automatic + OBOL:automatic Note that in MA, this is a subclass of pelvis muscle; in FMA this is a hindlimb muscle, but recall in FMA hindlimb includes the girdle. - MA + MA girdle-pelvic muscle organ - OBOL:automatic + OBOL:automatic muscle organ of girdle-pelvic - OBOL:automatic + OBOL:automatic muscle organ of pelvic girdle - OBOL:automatic + OBOL:automatic muscle organ of pelvic girdle bone - OBOL:automatic + OBOL:automatic pelvic girdle muscle organ - OBOL:automatic + OBOL:automatic @@ -256843,6 +71301,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -256885,6 +71344,8 @@ The modern definition of neurosecretion has evolved to include the release of an The curving portion between the ascending aorta and the descending aorta, giving rise to the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery. [TFD][VHOG] The double systemic arch arches (left and right) present in amphibians and reptiles become reduced to a single systemic arch - the right in birds, the left in mammals.[well established][VHOG] birds have right aortic arch, mammals left. + + BTO:0000157 EFO:0002526 EHDAA2:0000132 @@ -256892,9 +71353,7 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:3768 GAID:471 MA:0000475 - SCTID:181300001 VHOG:0001196 - Wikipedia:Arch_of_aorta arcus aortae uberon aortic arch @@ -256904,9 +71363,7 @@ The modern definition of neurosecretion has evolved to include the release of an arch of aorta - http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb + http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg @@ -256924,35 +71381,35 @@ The modern definition of neurosecretion has evolved to include the release of an The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0004113 The curving portion between the ascending aorta and the descending aorta, giving rise to the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001196 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/arch+of+aorta + VHOG + + The double systemic arch arches (left and right) present in amphibians and reptiles become reduced to a single systemic arch - the right in birds, the left in mammals.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001196 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.460 and p.461 Figure 12.20 - http://bgee.unil.ch/ arcus aortae FMA:3768 - FMA:TA + FMA:TA @@ -257013,13 +71470,15 @@ The modern definition of neurosecretion has evolved to include the release of an The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted]. results from fusion of left and right dorsal aortae + + + EMAPA:18606 FMA:3784 MA:0002571 NCIT:C32455 - SCTID:261399002 + OpenCyc:Mx4rv4EE35wpEbGdrcN5Y29ycA UMLS:C0011666 - Wikipedia:Descending_aorta pars descendens aortae uberon aorta descendens @@ -257029,15 +71488,13 @@ The modern definition of neurosecretion has evolved to include the release of an descending aorta - http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb + http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg - FMA + FMA @@ -257048,7 +71505,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -257059,14 +71516,14 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted]. + GO:0035906 - Wikipedia:Descending_aorta @@ -257084,14 +71541,20 @@ The modern definition of neurosecretion has evolved to include the release of an aorta descendens - Wikipedia:Descending_aorta + + + + + + aorta descendens + pars descendens aortae - Wikipedia:Descending_aorta + @@ -257125,6 +71588,9 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest. + + + BTO:0000157 EFO:0002525 EMAPA:18603 @@ -257133,9 +71599,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002569 MESH:D001013 NCIT:C33766 - SCTID:302510009 + OpenCyc:Mx4rveb9TpwpEbGdrcN5Y29ycA UMLS:C1522460 - Wikipedia:Thoracic_aorta galen:ThoracicAorta aorta thoracica thoracic part of aorta @@ -257147,20 +71612,20 @@ The modern definition of neurosecretion has evolved to include the release of an thoracic aorta - http://upload.wikimedia.org/wikipedia/commons/7/75/Gray530.png + http://upload.wikimedia.org/wikipedia/commons/7/75/Gray530.png - FMA + FMA The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest. + MP:0010468 - http://www.medterms.com @@ -257173,21 +71638,21 @@ The modern definition of neurosecretion has evolved to include the release of an aorta thoracica FMA:3786 - FMA:TA + FMA:TA aorta thoracalis - Wikipedia:Thoracic_aorta + pars thoracica aortae - Wikipedia:Thoracic_aorta + @@ -257224,6 +71689,9 @@ The modern definition of neurosecretion has evolved to include the release of an Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted]. Many of the branches of the abdominal aorta in mammals may be branches of the dorsal aorta in other vertebrates + + + BTO:0002976 EFO:0002524 EMAPA:17856 @@ -257232,9 +71700,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000474 MESH:D001012 NCIT:C32038 - SCTID:244231007 + OpenCyc:Mx4rvYhWCZwpEbGdrcN5Y29ycA UMLS:C0003484 - Wikipedia:Abdominal_aorta galen:AbdominalAorta abdominal part of aorta descending abdominal aorta @@ -257249,7 +71716,7 @@ The modern definition of neurosecretion has evolved to include the release of an abdominal aorta - http://upload.wikimedia.org/wikipedia/commons/a/af/Gray531.png + http://upload.wikimedia.org/wikipedia/commons/a/af/Gray531.png @@ -257260,14 +71727,14 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted]. + BTO:0002976 - Wikipedia:Abdominal_aorta @@ -257299,12 +71766,24 @@ The modern definition of neurosecretion has evolved to include the release of an abdominal part of aorta BTO:0002976 + + + + aorta abdominalis + + + aorta abdominalis BTO:0002976 - Wikipedia:Abdominal_aorta + + + + + pars abdominalis aortae + @@ -257312,8 +71791,6 @@ The modern definition of neurosecretion has evolved to include the release of an pars abdominalis aortae BTO:0002976 - Wikipedia:Abdominal_aorta - @@ -257349,6 +71826,9 @@ The modern definition of neurosecretion has evolved to include the release of an The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery. innominate + + + EFO:0002550 EHDAA2:0000835 EMAPA:17615 @@ -257357,9 +71837,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001922 MESH:D016122 NCIT:C32814 - SCTID:244244002 + OpenCyc:Mx4rv9mMTpwpEbGdrcN5Y29ycA UMLS:C0006094 - Wikipedia:Brachiocephalic_artery galen:BrachioCephalicArtery brachiocephalic trunk innominate artery @@ -257372,22 +71851,20 @@ The modern definition of neurosecretion has evolved to include the release of an brachiocephalic artery - http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb + http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery. - MGI:csmith + MGI:csmith MP:0010663 innominate - Wikipedia:Brachiocephalic_artery + @@ -257405,21 +71882,21 @@ The modern definition of neurosecretion has evolved to include the release of an innominate artery - Wikipedia:Brachiocephalic_artery + truncus brachiocephalicus FMA:3932 - FMA:TA + FMA:TA truncus brachiocephalicus - Wikipedia:Brachiocephalic_artery + @@ -257429,6 +71906,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -257459,6 +71937,9 @@ The modern definition of neurosecretion has evolved to include the release of an in birds and reptiles, develops from arch III and parts of ventral and dorsal aortae carotid artery + + + CALOHA:TS-0116 EHDAA2:0000217 EHDAA:7331 @@ -257468,10 +71949,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001926 MESH:D017536 NCIT:C32352 - SCTID:362041005 UMLS:C0162859 VHOG:0000272 - Wikipedia:Common_carotid_artery carotid artery system common carotid artery trunk of common carotid tree @@ -257482,13 +71961,13 @@ The modern definition of neurosecretion has evolved to include the release of an common carotid artery plus branches - http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg + http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg - FMA + FMA @@ -257499,13 +71978,13 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]. - Wikipedia:Common_carotid_artery + @@ -257542,7 +72021,7 @@ The modern definition of neurosecretion has evolved to include the release of an a. carotis communis - Wikipedia:Common_carotid_artery + @@ -257594,6 +72073,9 @@ The modern definition of neurosecretion has evolved to include the release of an Artery which supplies blood via branches to the various muscles of the shoulder region and to the forelimb.[AAO] In human anatomy, the subclavian artery is a major artery of the upper thorax that mainly supplies blood to the head and arms. It is located below the clavicle, hence the name. There is a left subclavian and a right subclavian. On the left side of the body, the subclavian comes directly off the arch of aorta. On the right side of the body, the subclavian arises from the relatively short brachiocephalic artery (trunk) when it bifurcates into the subclavian and the right common carotid artery. The usual branches of the subclavian on both sides of the body are the vertebral artery, the internal thoracic artery, the thyrocervical trunk, the costocervical trunk and the dorsal scapular artery. The subclavian becomes the axillary artery at the lateral border of the first rib[WP] The pectoral (subclavian) arteries originate from the dorsal aorta and takes the blood outward into the fin from the paired portion of the dorsal aorta posterior to the last aortic arch. Kimmel et al. 1993[TAO] + + + AAO:0010232 EHDAA2:0001933 EHDAA:4357 @@ -257603,10 +72085,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002045 MESH:D013348 NCIT:C33643 - SCTID:265790007 + OpenCyc:Mx4rvp8u1JwpEbGdrcN5Y29ycA TAO:0005086 UMLS:C0038530 - Wikipedia:Subclavian_artery XAO:0000365 ZFA:0005086 arteria subclavia @@ -257623,7 +72104,7 @@ The modern definition of neurosecretion has evolved to include the release of an subclavian artery - http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg + http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg @@ -257634,7 +72115,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -257645,38 +72126,38 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta. - ISBN:0073040584 - https://orcid.org/0000-0002-6601-2165 + + ISBN:0073040584 Artery which supplies blood via branches to the various muscles of the shoulder region and to the forelimb.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010232 - AAO - AAO:BJB + AAO + AAO:BJB In human anatomy, the subclavian artery is a major artery of the upper thorax that mainly supplies blood to the head and arms. It is located below the clavicle, hence the name. There is a left subclavian and a right subclavian. On the left side of the body, the subclavian comes directly off the arch of aorta. On the right side of the body, the subclavian arises from the relatively short brachiocephalic artery (trunk) when it bifurcates into the subclavian and the right common carotid artery. The usual branches of the subclavian on both sides of the body are the vertebral artery, the internal thoracic artery, the thyrocervical trunk, the costocervical trunk and the dorsal scapular artery. The subclavian becomes the axillary artery at the lateral border of the first rib[WP] - Wikipedia:Subclavian_artery + The pectoral (subclavian) arteries originate from the dorsal aorta and takes the blood outward into the fin from the paired portion of the dorsal aorta posterior to the last aortic arch. Kimmel et al. 1993[TAO] - 2012-08-14 + 2012-08-14 TAO:0005086 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -257695,13 +72176,13 @@ The modern definition of neurosecretion has evolved to include the release of an PA - + arteria subclavia - Wikipedia:Subclavian_artery + @@ -257739,14 +72220,17 @@ The modern definition of neurosecretion has evolved to include the release of an in humans, arises from the relatively short brachiocephalic artery (trunk) when it bifurcates into the subclavian and the right common carotid artery proximal part arises from right 4th aortic arch in humans + + + EHDAA2:0004514 EMAPA:37384 FMA:3953 MA:0002047 NCIT:C33490 - SCTID:244246000 + OpenCyc:Mx4rtW7hwqgEEdudWQACs5b6Bw + OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rvp8u1JwpEbGdrcN5Y29ycA UMLS:C0226261 - Wikipedia:Subclavian_artery arteria subclavia dextra uberon UBERON:0001534 @@ -257754,19 +72238,19 @@ The modern definition of neurosecretion has evolved to include the release of an right subclavian artery - http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg + http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg The subclavian artery that supplies the right pectoral appendage. - http://orcid.org/0000-0002-6601-2165 + EMAPA:37384 - MA:th + MA:th @@ -257779,7 +72263,7 @@ The modern definition of neurosecretion has evolved to include the release of an arteria subclavia dextra FMA:3953 - FMA:TA + FMA:TA @@ -257789,6 +72273,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -257854,13 +72339,13 @@ The modern definition of neurosecretion has evolved to include the release of an A tube extending from the mouth to the anus. - The alimentary or digestive tract, and associated organs.[TAO] The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] FMA also has a term 'gastrointestinal tract', but this includes the liver. we place the MA and EMAPA class here, although the intent is probably a smaller region. See https://github.com/obophenotype/uberon/issues/509 we following Kardong in naming the entire tube from mouth to anus the alimentary canal. Kardong calls the portion of this tract that excludes buccal cavity and pharynx the 'alimentary canal', consider adding an extra class for this gut + AAO:0010023 BILA:0000083 BTO:0000511 @@ -257872,6 +72357,7 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:45615 MA:0000917 NCIT:C34082 + OpenCyc:Mx4rvVi0GpwpEbGdrcN5Y29ycA TAO:0000112 TGMA:0001819 UMLS:C0017189 @@ -257887,7 +72373,6 @@ The modern definition of neurosecretion has evolved to include the release of an digestive canal gut tube UBERON:0001555 - digestive tract @@ -257907,51 +72392,51 @@ The modern definition of neurosecretion has evolved to include the release of an A tube extending from the mouth to the anus. - Wikipedia:Talk:Human_gastrointestinal_tract - https://github.com/geneontology/go-ontology/issues/7549 + + - Wikipedia:Acoelomorpha + - DOI:10.1371/journal.pone.0016309 + The alimentary or digestive tract, and associated organs.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000112 - TAO - ZFIN:curator + TAO + ZFIN:curator The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000309 - VHOG + VHOG + ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11 - http://bgee.unil.ch/ FMA also has a term 'gastrointestinal tract', but this includes the liver. - FMA + FMA we place the MA and EMAPA class here, although the intent is probably a smaller region. See https://github.com/obophenotype/uberon/issues/509 - MA + MA @@ -257986,13 +72471,14 @@ The modern definition of neurosecretion has evolved to include the release of an The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]. + + EHDAA2:0001036 EMAPA:16738 FMA:45662 MA:0000435 - SCTID:281488008 + OpenCyc:Mx4rQRqjUgAKEdyHxgDggVfs8g VHOG:0000382 - Wikipedia:Lower_respiratory_tract lower respiratory system uberon UBERON:0001558 @@ -258000,15 +72486,15 @@ The modern definition of neurosecretion has evolved to include the release of an lower respiratory tract - http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg - http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg + http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg + http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]. - Wikipedia:Lower_respiratory_tract - http://orcid.org/0000-0002-6601-2165 + + @@ -258051,13 +72537,16 @@ The modern definition of neurosecretion has evolved to include the release of an in humans, branches off the arch of aorta arises from left intersegmental 6th artery in the region of the 6th -7th cervical segment in humans + + + EMAPA:37100 FMA:4694 MA:0002046 NCIT:C32972 - SCTID:244245001 + OpenCyc:Mx4rtW7hw6gEEdudWQACs5b6Bw + OpenCyc:Mx8Ngh4rvgIFoJwpEbGdrcN5Y29ycB4rvp8u1JwpEbGdrcN5Y29ycA UMLS:C0226262 - Wikipedia:Subclavian_artery arteria subclavia (sinistra) uberon UBERON:0001584 @@ -258065,21 +72554,19 @@ The modern definition of neurosecretion has evolved to include the release of an left subclavian artery - http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb + http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg The subclavian artery that supplies the left pectoral appendage. - http://orcid.org/0000-0002-6601-2165 + EMAPA:37100 - MA:th + MA:th @@ -258092,7 +72579,7 @@ The modern definition of neurosecretion has evolved to include the release of an arteria subclavia (sinistra) FMA:4694 - FMA:TA + FMA:TA @@ -258135,6 +72622,9 @@ The modern definition of neurosecretion has evolved to include the release of an Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG] The mouse has both left and right anterior vena cava. adult humans only have a right. Postnatally the left regresses and becomes non-functional (Wessels and Sedmera 2003). In the mouse, The right pulmonary vein passes dorsal to the right superior vena cava, the left pulmonary dorsal to the left superior vena cava (Biology of the Laboratory Mouse, Green). + + + BTO:0002683 EHDAA2:0001962 EHDAA:8726 @@ -258144,10 +72634,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000481 MESH:D014683 NCIT:C12816 - SCTID:181368006 UMLS:C0042459 VHOG:0001195 - Wikipedia:Superior_vena_cava galen:SuperiorVenaCava superior caval vein superior vena cava @@ -258161,30 +72649,30 @@ The modern definition of neurosecretion has evolved to include the release of an anterior vena cava - http://upload.wikimedia.org/wikipedia/commons/b/b4/Venenwinkel.png + http://upload.wikimedia.org/wikipedia/commons/b/b4/Venenwinkel.png - lexical + lexical A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart. - Wikipedia:Superior_vena_cava - http://orcid.org/0000-0002-6601-2165 + + Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001195 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.454-455 - http://bgee.unil.ch/ @@ -258196,7 +72684,7 @@ The modern definition of neurosecretion has evolved to include the release of an superior caval vein - http://orcid.org/0000-0002-6601-2165 + @@ -258214,15 +72702,20 @@ The modern definition of neurosecretion has evolved to include the release of an vena cava superior - BTO:0002683 - Wikipedia:Superior_vena_cava + + + + + vena cava superior + BTO:0002683 + vena maxima - Wikipedia:Superior_vena_cava + @@ -258253,6 +72746,9 @@ The modern definition of neurosecretion has evolved to include the release of an One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]. Vein which receives many veins draining the palate, brain, and the orbital, nasal, and auditory regions.[AAO] + + + AAO:0010236 EHDAA2:0000877 EHDAA:5407 @@ -258260,10 +72756,9 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:4724 MA:0002157 NCIT:C32849 + OpenCyc:Mx4rvqdb95wpEbGdrcN5Y29ycA RETIRED_EHDAA2:0000878 - SCTID:181372005 UMLS:C0226550 - Wikipedia:Internal_jugular_vein XAO:0000382 galen:InternalJugularVein internal jugular @@ -258274,22 +72769,22 @@ The modern definition of neurosecretion has evolved to include the release of an internal jugular vein - http://upload.wikimedia.org/wikipedia/commons/e/e9/Gray562.png + http://upload.wikimedia.org/wikipedia/commons/e/e9/Gray562.png One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]. - Wikipedia:Internal_jugular_vein + Vein which receives many veins draining the palate, brain, and the orbital, nasal, and auditory regions.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010236 - AAO - AAO:BJB + AAO + AAO:BJB @@ -258307,12 +72802,71 @@ The modern definition of neurosecretion has evolved to include the release of an vena jugularis interna - Wikipedia:Internal_jugular_vein + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted]. + + + + + EMAPA:36284 + FMA:4749 + MA:0002088 + NCIT:C53031 + UMLS:C0226650 + bronchial venous tree + uberon + UBERON:0001592 + + + bronchial vein + + + + + The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted]. + + + + + + UMLS:C0226650 + ncithesaurus:Bronchial_Vein + + + + @@ -258332,38 +72886,37 @@ The modern definition of neurosecretion has evolved to include the release of an The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]. - + + + BTO:0000654 EMAPA:35240 FMA:49151 MA:0001269 NCIT:C32315 - SCTID:280862009 UMLS:C0559230 - Wikipedia:Ciliary_muscle musculus ciliarus uberon Bowman`s muscles ciliaris musculus ciliaris UBERON:0001605 - ciliary muscle - http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png + http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png - MA + MA - FMA + FMA @@ -258374,13 +72927,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]. - Wikipedia:Ciliary_muscle + @@ -258404,13 +72957,13 @@ The modern definition of neurosecretion has evolved to include the release of an ciliaris - Wikipedia:Ciliary_muscle + musculus ciliaris - Wikipedia:Ciliary_muscle + @@ -258437,15 +72990,14 @@ The modern definition of neurosecretion has evolved to include the release of an - . revisit this, see issue #331 The muscle cells of the iris are smooth muscle in mammals and amphibians, but are striated muscle in birds and reptiles. Many fish have neither, and, as a result, their irides are unable to dilate and contract, so that the pupil always remains of a fixed size[Romer, via WP] in aves, stromal mesenchymal cells may migrate to the iris and become skeletal + + EMAPA:35448 FMA:49154 MA:0001287 - SCTID:280888007 - Wikipedia:Iris_muscle iris muscle iris muscle organ muscle organ of iris @@ -258458,25 +73010,19 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA - - - - - . - Wikipedia:Iris_muscle + FMA iris muscle organ - OBOL:automatic + OBOL:automatic muscle organ of iris - OBOL:automatic + OBOL:automatic @@ -258538,14 +73084,15 @@ The modern definition of neurosecretion has evolved to include the release of an In humans, it functions to constrict the pupil in bright light or during accommodation. Its dimensions are about 0.75 mm wide by 0.15 mm thick. It is controlled by parasympathetic fibers that originate from the Edinger-Westphal nucleus, travel along the oculomotor nerve (CN III), synapse in the ciliary ganglion, and then enter the eye via the short ciliary nerves. Initially, all the myocytes are of the smooth muscle type, but much later in life, so that ultimately most cells are of the striated muscle type. [WP,unvetted] WP says: It is found in vertebrates and some cephalopods; this class refers to the vertebrate structure constricts iris + + + BTO:0000656 EMAPA:35788 FMA:49157 MA:0001289 NCIT:C33586 - SCTID:280889004 UMLS:C0229189 - Wikipedia:Iris_sphincter_muscle M. sphincter pupillae iris sphincter muscle musculus sphincter pupillae @@ -258566,13 +73113,13 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0001607 sphincter pupillae - http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray878.png + http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray878.png - BTO + BTO @@ -258595,7 +73142,7 @@ The modern definition of neurosecretion has evolved to include the release of an encircles iris - dbpedia + dbpedia @@ -258607,7 +73154,7 @@ The modern definition of neurosecretion has evolved to include the release of an encircles iris - dbpedia + dbpedia @@ -258618,13 +73165,13 @@ The modern definition of neurosecretion has evolved to include the release of an - dbpedia + dbpedia A sphincter muscle that is part of the iris. - Wikipedia:Iris_sphincter_muscle + @@ -258654,68 +73201,68 @@ The modern definition of neurosecretion has evolved to include the release of an circular fibers - Wikipedia:Iris_sphincter_muscle + constrictor pupillae - Wikipedia:Iris_sphincter_muscle + iris constrictor muscle - Wikipedia:Iris_sphincter_muscle + iris sphincter - Wikipedia:Iris_sphincter_muscle + m. sphincter pupillae - Wikipedia:Iris_sphincter_muscle + pupillary constrictor muscle - Wikipedia:Iris_sphincter_muscle + pupillary sphincter - Wikipedia:Iris_sphincter_muscle + pupillary sphincter muscle - Wikipedia:Iris_sphincter_muscle + sphincter pupillae - Wikipedia:Iris_sphincter_muscle + sphincter pupillae muscle - Wikipedia:Iris_sphincter_muscle + spincter pupillae - Wikipedia:Iris_sphincter_muscle + @@ -258755,16 +73302,16 @@ The modern definition of neurosecretion has evolved to include the release of an A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted]. - It is innervated by the sympathetic system, which acts by releasing noradrenaline, which acts on alpha1-receptors. Thus, when presented with a threatening stimuli that activates the fight-or-flight response, this innervation dilates the iris, thus temporarily letting more light reach the retina + + + BTO:0001371 EMAPA:35286 FMA:49158 MA:0001288 NCIT:C32463 - SCTID:280890008 UMLS:C0229190 - Wikipedia:Iris_dilator_muscle dilator muscle of pupil dilator of pupil dilator pupillae @@ -258785,16 +73332,15 @@ The modern definition of neurosecretion has evolved to include the release of an radial muscle radiating fibers UBERON:0001608 - dilatator pupillae - http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray878.png + http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray878.png - BTO + BTO @@ -258817,7 +73363,7 @@ The modern definition of neurosecretion has evolved to include the release of an outer margins of iris - dbpedia + dbpedia @@ -258829,7 +73375,7 @@ The modern definition of neurosecretion has evolved to include the release of an inner margins of iris - dbpedia + dbpedia @@ -258840,13 +73386,13 @@ The modern definition of neurosecretion has evolved to include the release of an - dbpedia + dbpedia A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted]. - Wikipedia:Iris_dilator_muscle + @@ -258858,7 +73404,7 @@ The modern definition of neurosecretion has evolved to include the release of an dilator pupillae muscle - Wikipedia:Iris_dilator_muscle + @@ -258871,20 +73417,20 @@ The modern definition of neurosecretion has evolved to include the release of an musculus dilatator pupillae FMA:49158 - FMA:TA + FMA:TA pupillary dilator muscle - Wikipedia:Iris_dilator_muscle + radial muscle of iris - Wikipedia:Iris_dilator_muscle + @@ -258896,13 +73442,13 @@ The modern definition of neurosecretion has evolved to include the release of an iris dilator - Wikipedia:Iris_dilator_muscle + musculus dilatator pupillae - Wikipedia:Iris_dilator_muscle + @@ -258915,37 +73461,37 @@ The modern definition of neurosecretion has evolved to include the release of an pupil dilator - Wikipedia:Iris_dilator_muscle + pupil dilator muscle - Wikipedia:Iris_dilator_muscle + pupillary dilator - Wikipedia:Iris_dilator_muscle + pupillary muscle - Wikipedia:Iris_dilator_muscle + radial muscle - Wikipedia:Iris_dilator_muscle + radiating fibers - Wikipedia:Iris_dilator_muscle + @@ -258962,7 +73508,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -258977,19 +73523,21 @@ The modern definition of neurosecretion has evolved to include the release of an - + A branch of the external carotid artery that supplies structures of the face. [WP,unvetted]. + + + EMAPA:19213 FMA:49549 MA:0001950 NCIT:C32578 - SCTID:181328007 + OpenCyc:Mx4rwCt95ZwpEbGdrcN5Y29ycA UMLS:C0226109 - Wikipedia:Facial_artery uberon arteria maxillaris externa external maxillary artery @@ -258997,13 +73545,13 @@ The modern definition of neurosecretion has evolved to include the release of an facial artery - http://upload.wikimedia.org/wikipedia/commons/7/7b/Gray508.png + http://upload.wikimedia.org/wikipedia/commons/7/7b/Gray508.png A branch of the external carotid artery that supplies structures of the face. [WP,unvetted]. - Wikipedia:Facial_artery + @@ -259015,7 +73563,7 @@ The modern definition of neurosecretion has evolved to include the release of an arteria maxillaris externa - Wikipedia:Facial_artery + @@ -259036,6 +73584,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -259063,6 +73612,9 @@ The modern definition of neurosecretion has evolved to include the release of an An artery that supplies deep structures of the face. It comes just out behind the neck of the mandible. [WP,unvetted]. ...1st pair undergoes partial regression, the remnants of which becomes part of the maxillary arteries + + + EHDAA2:0001069 EHDAA:7357 EMAPA:17311 @@ -259071,9 +73623,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001919 MESH:D008438 NCIT:C34205 - SCTID:181326006 + OpenCyc:Mx4rwDDJ45wpEbGdrcN5Y29ycA UMLS:C0024949 - Wikipedia:Maxillary_artery uberon arteria maxillaris internal maxillary artery @@ -259081,19 +73632,19 @@ The modern definition of neurosecretion has evolved to include the release of an maxillary artery - http://upload.wikimedia.org/wikipedia/commons/3/39/Gray510.png + http://upload.wikimedia.org/wikipedia/commons/3/39/Gray510.png An artery that supplies deep structures of the face. It comes just out behind the neck of the mandible. [WP,unvetted]. - Wikipedia:Maxillary_artery + ...1st pair undergoes partial regression, the remnants of which becomes part of the maxillary arteries - http://download.videohelp.com/vitualis/med/Vascular_Devt.html + @@ -259105,7 +73656,7 @@ The modern definition of neurosecretion has evolved to include the release of an arteria maxillaris - Wikipedia:Maxillary_artery + @@ -259144,6 +73695,7 @@ The modern definition of neurosecretion has evolved to include the release of an It seems clear that the metazoan ancestor inherited from its unicellular descendants an actin cytoskeleton and motor-proteins of the myosin superfamily. Within metazoans, these two molecules were arranged into effective contractile units, the muscles. The basic trends for muscle evolution are already expressed in the diploblastic taxa.[well established][VHOG] muscular muscle + AAO:0011066 EMAPA:32715 EMAPA:37474 @@ -259151,7 +73703,7 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:5022 GAID:131 MA:0000015 - SCTID:71616004 + OpenCyc:Mx4rv2kf-5wpEbGdrcN5Y29ycA TAO:0005145 VHOG:0001245 XAO:0000172 @@ -259175,20 +73727,20 @@ The modern definition of neurosecretion has evolved to include the release of an Portion of tissue composed of contractile fibers.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005145 - TAO - ZFIN:curator + TAO + ZFIN:curator It seems clear that the metazoan ancestor inherited from its unicellular descendants an actin cytoskeleton and motor-proteins of the myosin superfamily. Within metazoans, these two molecules were arranged into effective contractile units, the muscles. The basic trends for muscle evolution are already expressed in the diploblastic taxa.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001245 - VHOG + VHOG + ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.75 - http://bgee.unil.ch/ @@ -259200,7 +73752,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37474 - MA:th + MA:th @@ -259228,6 +73780,9 @@ The modern definition of neurosecretion has evolved to include the release of an arterial Some arthropods have primitive arterial systems but this term refers to arteries in a true closed circulatory system. + + + AAO:0010211 AEO:0000208 BTO:0000573 @@ -259244,11 +73799,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D001158 MIAA:0000034 NCIT:C12372 - SCTID:362877004 + OpenCyc:Mx4rvVjknZwpEbGdrcN5Y29ycA TAO:0000005 UMLS:C0003842 VHOG:0001251 - Wikipedia:Artery XAO:0000114 ZFA:0000005 galen:Artery @@ -259275,20 +73829,20 @@ The modern definition of neurosecretion has evolved to include the release of an Part of the circulatory system composed of blood vessels which carry oxygenated blood away from the heart to the rest of the body.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010211 - AAO - AAO:BJB + AAO + AAO:BJB The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001251 - VHOG + VHOG + DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006) - http://bgee.unil.ch/ @@ -259301,7 +73855,7 @@ The modern definition of neurosecretion has evolved to include the release of an arteries TAO:0000005 - + @@ -259341,6 +73895,9 @@ The modern definition of neurosecretion has evolved to include the release of an venous subtree venous vessel + + + AAO:0010212 AEO:0000209 BTO:0000234 @@ -259356,11 +73913,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D014680 MIAA:0000037 NCIT:C12814 - SCTID:181367001 + OpenCyc:Mx4rvVjkWpwpEbGdrcN5Y29ycA TAO:0000082 UMLS:C0042449 VHOG:0001743 - Wikipedia:Vein XAO:0000115 ZFA:0000082 galen:Vein @@ -259375,32 +73931,32 @@ The modern definition of neurosecretion has evolved to include the release of an vein - http://upload.wikimedia.org/wikipedia/commons/c/c2/Venous_system_en.svg + http://upload.wikimedia.org/wikipedia/commons/c/c2/Venous_system_en.svg Any of the tubular branching vessels that carry blood from the capillaries toward the heart. - Wikipedia:Vein + Part of the circulatory system composed of blood vessels which carry blood from other organs, tissues, and cells to the heart.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010212 - AAO - AAO:BJB + AAO + AAO:BJB The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001743 - VHOG + VHOG + DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006) - http://bgee.unil.ch/ @@ -259418,7 +73974,7 @@ The modern definition of neurosecretion has evolved to include the release of an vena - Wikipedia:Vein + @@ -259426,7 +73982,7 @@ The modern definition of neurosecretion has evolved to include the release of an venae VHOG:0001743 - + @@ -259457,12 +74013,12 @@ The modern definition of neurosecretion has evolved to include the release of an Adults of all vertebrates lose the vitelline veins and establish a single large hepatic portal vein (...) by the selective retention of parts of the left and right subintestinals and of several anastomoses that occur between them within and just posterior to the liver.[well established][VHOG] In humans A vein in the abdominal cavity that drains blood from the gastrointestinal tract and spleen. It is usually formed by the confluence of the superior mesenteric and splenic veins, and also receives blood from the inferior mesenteric, gastric, and cystic veins. The hepatic portal vein is a major component of the hepatic portal system, one of the main portal venous systems in the body. Conditions involving the hepatic portal vein cause considerable illness and death. An important example of such a condition is elevated blood pressure in the hepatic portal vein. This condition, called portal hypertension, is a major complication of cirrhosis worldwide. [WP,unvetted] + AAO:0010214 FMA:50735 MA:0002132 TAO:0005090 VHOG:0000642 - Wikipedia:Hepatic_portal_vein ZFA:0005090 hepatic portal tree liver portal vein @@ -259479,45 +74035,43 @@ The modern definition of neurosecretion has evolved to include the release of an hepatic portal vein - http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb + http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png - MA + MA A portal vein that transports nutrients from the digestive tract to the liver[Kardong]. - ISBN:0073040584 - Wikipedia:Hepatic_portal_vein - http://sourceforge.net/tracker/?func=detail&aid=3091300&group_id=76834&atid=1205376 + + + ISBN:0073040584 Adults of all vertebrates lose the vitelline veins and establish a single large hepatic portal vein (...) by the selective retention of parts of the left and right subintestinals and of several anastomoses that occur between them within and just posterior to the liver.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000642 - VHOG + VHOG + ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.265 - http://bgee.unil.ch/ liver portal vein - OBOL:automatic + OBOL:automatic portal vein of liver - OBOL:automatic + OBOL:automatic @@ -259535,7 +74089,7 @@ The modern definition of neurosecretion has evolved to include the release of an vena portae hepatis - Wikipedia:Hepatic_portal_vein + @@ -259578,6 +74132,9 @@ The modern definition of neurosecretion has evolved to include the release of an The first major branch of the abdominal aorta. + + + EHDAA2:0004519 EMAPA:35202 FMA:50737 @@ -259585,9 +74142,7 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001931 MESH:D002445 NCIT:C52846 - SCTID:181340007 UMLS:C0007569 - Wikipedia:Celiac_artery celiac tree coeliac artery uberon @@ -259605,13 +74160,13 @@ The modern definition of neurosecretion has evolved to include the release of an dorsal aorta in Kardong celiac artery - http://upload.wikimedia.org/wikipedia/commons/6/65/Gray532.png + http://upload.wikimedia.org/wikipedia/commons/6/65/Gray532.png - FMA + FMA @@ -259623,7 +74178,7 @@ The modern definition of neurosecretion has evolved to include the release of an dorsal aorta in primitive verts - Wikipedia + Wikipedia @@ -259634,7 +74189,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ISBN:0073040584 + ISBN:0073040584 @@ -259645,7 +74200,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ISBN:0073040584 + ISBN:0073040584 @@ -259656,7 +74211,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ISBN:0073040584 + ISBN:0073040584 @@ -259667,13 +74222,13 @@ The modern definition of neurosecretion has evolved to include the release of an - ISBN:0073040584 + ISBN:0073040584 The first major branch of the abdominal aorta. - Wikipedia:Celiac_artery + @@ -259685,58 +74240,64 @@ The modern definition of neurosecretion has evolved to include the release of an coeliac artery - Wikipedia:Celiac_artery + arteria coeliaca - Wikipedia:Celiac_artery + arteria cœliaca - Wikipedia:Celiac_artery + celiac trunk - Wikipedia:Celiac_artery + coeliac axis - Wikipedia:Celiac_artery + coeliac trunck - Wikipedia:Celiac_artery + coeliac trunk - Wikipedia:Celiac_artery + + + + + + truncus coeliacus + truncus coeliacus - Wikipedia:Celiac_artery + truncus cœliacus - Wikipedia:Celiac_artery + @@ -259811,6 +74372,9 @@ The modern definition of neurosecretion has evolved to include the release of an We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG] the ophthalmic usually usually merges with the other two. In some vertebrates, the ophthalmic emerges from the brain separately[Kardong] The trigeminal nerve has 3 branches in mammals - similar branches are present in nonmammalian vertebrates, but in some a separate profundus nerve that corresponds to opthalmic branch in mammls 5n + + + AAO:0010470 BAMS:5n BAMS:Vn @@ -259830,11 +74394,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D014276 MFMO:0000093 NCIT:C12806 - SCTID:362459002 + OpenCyc:Mx4rwMF8CJwpEbGdrcN5Y29ycA TAO:0000697 UMLS:C0040996 VHOG:0000704 - Wikipedia:Trigeminal_nerve XAO:0003092 ZFA:0000697 neuronames:549 @@ -259858,7 +74421,7 @@ The modern definition of neurosecretion has evolved to include the release of an trigeminal nerve - https://upload.wikimedia.org/wikipedia/commons/9/99/Gray778_Trigeminal.png + https://upload.wikimedia.org/wikipedia/commons/9/99/Gray778_Trigeminal.png @@ -259869,53 +74432,58 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw). - ISBN:0471209627 - Wikipedia:Trigeminal_nerve + + ISBN:0471209627 Nerve consists of motor and sensory components. Ganglion cells of the sensory component form the proximal part of the trigeminal (Gasserian) ganglion. From the ganglion 3 major rami innervate jaws, snout, and buccal roof.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010470 - AAO - AAO:EJS + AAO + AAO:EJS We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000704 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 - http://bgee.unil.ch/ the ophthalmic usually usually merges with the other two. In some vertebrates, the ophthalmic emerges from the brain separately[Kardong] The trigeminal nerve has 3 branches in mammals - similar branches are present in nonmammalian vertebrates, but in some a separate profundus nerve that corresponds to opthalmic branch in mammls - ISBN:0471888893 + ISBN:0471888893 5n BIRNLEX:869 - NIFSTD:NeuroNames_abbrevSource - + NIFSTD:NeuroNames_abbrevSource + UMLS:C0040996 BIRNLEX:869 + + + + + UMLS:C0040996 ncithesaurus:Trigeminal_Nerve @@ -259928,7 +74496,7 @@ The modern definition of neurosecretion has evolved to include the release of an nervus trigeminus - Wikipedia:Trigeminal_nerve + @@ -259936,7 +74504,7 @@ The modern definition of neurosecretion has evolved to include the release of an nervus trigeminus [v] FMA:50866 - FMA:TA + FMA:TA @@ -260002,13 +74570,14 @@ The modern definition of neurosecretion has evolved to include the release of an The pulmonary artery that supplies the right lung. TODO - add class 'pulmonary artery tree organ' + + + EMAPA:37378 FMA:50872 MA:0002500 NCIT:C33489 - SCTID:244235003 UMLS:C0923924 - Wikipedia:Right_pulmonary_artery galen:RightPulmonaryArtery right main pulmonary artery right pulmonary arterial tree @@ -260018,22 +74587,20 @@ The modern definition of neurosecretion has evolved to include the release of an right pulmonary artery - http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray504.png - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb - https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png + http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray504.png + https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png The pulmonary artery that supplies the right lung. - UBERON:cjm + UBERON:cjm EMAPA:37378 - MA:th + MA:th @@ -260045,7 +74612,7 @@ The modern definition of neurosecretion has evolved to include the release of an arteria pulmonalis dextra - Wikipedia:Right_pulmonary_artery + @@ -260087,13 +74654,14 @@ The modern definition of neurosecretion has evolved to include the release of an The pulmonary artery that supplies the left lung. TODO - add class 'pulmonary artery tree organ' + + + EMAPA:37097 FMA:50873 MA:0002032 NCIT:C32971 - SCTID:244234004 UMLS:C0923925 - Wikipedia:Left_pulmonary_artery galen:LeftPulmonaryArtery left main pulmonary artery left pulmonary arterial tree @@ -260103,22 +74671,20 @@ The modern definition of neurosecretion has evolved to include the release of an left pulmonary artery - http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray504.png - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb - https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png + http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray504.png + https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png The pulmonary artery that supplies the left lung. - UBERON:cjm + UBERON:cjm EMAPA:37097 - MA:th + MA:th @@ -260130,7 +74696,7 @@ The modern definition of neurosecretion has evolved to include the release of an arteria pulmonalis sinistra - Wikipedia:Left_pulmonary_artery + @@ -260163,14 +74729,16 @@ The modern definition of neurosecretion has evolved to include the release of an Vein which collects blood from muscles of the head and drains into the external jugular vein.[AAO] MA and NCITA also has 'anterior facial vein' + + + AAO:0010513 EMAPA:19220 FMA:50874 MA:0002115 NCIT:C32579 - SCTID:181374006 + OpenCyc:Mx4rvziz3JwpEbGdrcN5Y29ycA UMLS:C0226532 - Wikipedia:Facial_vein face vein vein of face uberon @@ -260180,7 +74748,7 @@ The modern definition of neurosecretion has evolved to include the release of an facial vein - http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png + http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png @@ -260191,28 +74759,28 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]. - Wikipedia:Facial_vein + Vein which collects blood from muscles of the head and drains into the external jugular vein.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010513 - AAO - AAO:BJB + AAO + AAO:BJB MA and NCITA also has 'anterior facial vein' - MA + MA @@ -260224,26 +74792,26 @@ The modern definition of neurosecretion has evolved to include the release of an face vein - OBOL:automatic + OBOL:automatic vein of face - OBOL:automatic + OBOL:automatic anterior facial vein - Wikipedia:Facial_vein + vena facialis anterior - Wikipedia:Facial_vein + @@ -260291,6 +74859,9 @@ The modern definition of neurosecretion has evolved to include the release of an + + + AAO:0011107 BAMS:5Gn BAMS:GV @@ -260305,11 +74876,9 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000511 MESH:D012668 NCIT:C62642 - SCTID:244449009 TAO:0000295 UMLS:C0040995 VHOG:0000694 - Wikipedia:Trigeminal_ganglion XAO:0000427 XAO:0000428 ZFA:0000295 @@ -260336,13 +74905,13 @@ The modern definition of neurosecretion has evolved to include the release of an trigeminal ganglion - http://upload.wikimedia.org/wikipedia/commons/6/69/Gray776.png + http://upload.wikimedia.org/wikipedia/commons/6/69/Gray776.png - ncithesaurus + ncithesaurus @@ -260353,30 +74922,30 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN The cranial ganglion that is associated with and extends fibers into the trigeminal nerve. - http://orcid.org/0000-0002-6601-2165 - http://www.ncbi.nlm.nih.gov/books/NBK53171 - https://github.com/obophenotype/uberon/issues/693 + + + A prominent collection of touch-sensory neurons of the trigeminal or fifth cranial nerve, positioned beside the brain between the eye and the ear. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000295 - TAO - ZFIN:curator + TAO + ZFIN:curator In Xenopus, the profundal and the trigeminal ganglia are separate distally but fused at their proximal end as they condense around NF stage 24. - PMID:21452441 + XAO:0004093 @@ -260395,7 +74964,7 @@ The modern definition of neurosecretion has evolved to include the release of an Gasserian ganglion - Wikipedia:Trigeminal_ganglion + @@ -260407,13 +74976,13 @@ The modern definition of neurosecretion has evolved to include the release of an ganglion of trigeminal complex - http://orcid.org/0000-0002-6601-2165 + semilunar ganglion - ISBN:0471888893 + ISBN:0471888893 @@ -260438,8 +75007,8 @@ The modern definition of neurosecretion has evolved to include the release of an Gasserian ganglia - Wikipedia:Trigeminal_ganglion - + + @@ -260451,22 +75020,27 @@ The modern definition of neurosecretion has evolved to include the release of an ganglion semilunare - Wikipedia:Trigeminal_ganglion + ganglion trigeminale - BTO:0001231 - Wikipedia:Trigeminal_ganglion + + + + + ganglion trigeminale + BTO:0001231 + trigeminal ganglia - + @@ -260519,34 +75093,34 @@ The modern definition of neurosecretion has evolved to include the release of an The bone at the lower, posterior part of the skull. - formed from the sclerotome of the occipital somites. It is not present in living or fossil agnathans or cartilaginous fishes, but appears to have arisen in parallel in many bony fishes. Incorporation of the occipital ver- tebrae into the skull was associated with the annexation of the upper part of the spinal cord into the brain, together with the first 2 spinal nerves as cranial nerves XI and XII fusion of basi-, exo- and supra-occipitals (and maybe tabular) + + + EMAPA:25112 FMA:52735 GAID:227 MA:0001468 MESH:D009777 NCIT:C12757 - SCTID:181796003 + OpenCyc:Mx4rwQtsiZwpEbGdrcN5Y29ycA UMLS:C0028784 - Wikipedia:Occipital_bone uberon occipital complex occipital squama os occipitale UBERON:0001676 - occipital bone - http://upload.wikimedia.org/wikipedia/commons/2/27/Gray194.png + http://upload.wikimedia.org/wikipedia/commons/2/27/Gray194.png - FMA + FMA @@ -260557,7 +75131,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -260568,7 +75142,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -260602,7 +75176,7 @@ The modern definition of neurosecretion has evolved to include the release of an - WP + WP @@ -260613,20 +75187,20 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:11523816 + The bone at the lower, posterior part of the skull. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0005269 formed from the sclerotome of the occipital somites. It is not present in living or fossil agnathans or cartilaginous fishes, but appears to have arisen in parallel in many bony fishes. Incorporation of the occipital ver- tebrae into the skull was associated with the annexation of the upper part of the spinal cord into the brain, together with the first 2 spinal nerves as cranial nerves XI and XII - PMID:11523816 + @@ -260644,13 +75218,13 @@ The modern definition of neurosecretion has evolved to include the release of an occipital complex - http://palaeos.com/vertebrates/bones/braincase/occiput.html + os occipitale - Wikipedia:Occipital_bone + @@ -260711,8 +75285,10 @@ The modern definition of neurosecretion has evolved to include the release of an An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended. - part of viscerocranium (facial skeleton) in FMA + + + CALOHA:TS-2343 EMAPA:18340 FMA:52736 @@ -260720,9 +75296,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001472 MESH:D013100 NCIT:C12790 - SCTID:272676008 + OpenCyc:Mx4rwAU9XpwpEbGdrcN5Y29ycA UMLS:C0037884 - Wikipedia:Sphenoid_bone os sphenoidale sphenoid sphenoidal bone @@ -260732,17 +75307,16 @@ The modern definition of neurosecretion has evolved to include the release of an os sphenoidum sphenoid complex UBERON:0001677 - sphenoid bone - http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg + http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg - FMA + FMA @@ -260753,7 +75327,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -260797,19 +75371,19 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended. - Wikipedia:Sphenoid_bone + part of viscerocranium (facial skeleton) in FMA - FMA + FMA @@ -260822,27 +75396,33 @@ The modern definition of neurosecretion has evolved to include the release of an os sphenoidale FMA:52736 - FMA:TA + FMA:TA butterfly bone - Wikipedia:Sphenoid_bone + + + + + + os sphenoidale + os sphenoidale - Wikipedia:Sphenoid_bone + os sphenoidum - Wikipedia:Sphenoid_bone + @@ -260884,12 +75464,14 @@ The modern definition of neurosecretion has evolved to include the release of an A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP]. - A light spongy bone located between the eye sockets, forming part of the walls and septum of the superior nasal cavity, and containing perforations for the passage of olfactory nerve fibers. [TFD][VHOG] The ethmoid region of the chondrocranium and the nasal capsules, which were largely unossified in early tetrapods and ancestral amniotes, are represented in mammals by the ethmoid and turbinates bones, respectively.[well established][VHOG] ethmoidal todo - homology e.g. mesethmoid of teleost Note the WP states the Neurocranium contains the ethmoid bone, both MA and FMA place the ethmoid as part of the viscerocranium. FMA also has it in neurocranium (via basicranium). Ideally we would have non-overlapping divisions of the skull, but for now we follow FMA + + + BTO:0004140 EMAPA:19018 FMA:52740 @@ -260897,26 +75479,24 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001483 MESH:D005004 NCIT:C12711 - SCTID:272674006 + OpenCyc:Mx4rvuUPh5wpEbGdrcN5Y29ycA UMLS:C0015027 VHOG:0001317 - Wikipedia:Ethmoid_bone ethmoid ethmoidal bone os ethmoidale uberon UBERON:0001679 - ethmoid bone - http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg + http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg - ISBN:0073040584 + ISBN:0073040584 @@ -260927,39 +75507,39 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP]. - Wikipedia:Ethmoid_bone + A light spongy bone located between the eye sockets, forming part of the walls and septum of the superior nasal cavity, and containing perforations for the passage of olfactory nerve fibers. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001317 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/ethmoid+bone + VHOG + + The ethmoid region of the chondrocranium and the nasal capsules, which were largely unossified in early tetrapods and ancestral amniotes, are represented in mammals by the ethmoid and turbinates bones, respectively.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001317 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.259 - http://bgee.unil.ch/ Note the WP states the Neurocranium contains the ethmoid bone, both MA and FMA place the ethmoid as part of the viscerocranium. FMA also has it in neurocranium (via basicranium). Ideally we would have non-overlapping divisions of the skull, but for now we follow FMA - MA + MA @@ -260979,13 +75559,18 @@ The modern definition of neurosecretion has evolved to include the release of an ethmoidal bone MP:0000101 + + + + os ethmoidale + + os ethmoidale FMA:52740 - FMA:TA - Wikipedia:Ethmoid + FMA:TA @@ -261024,15 +75609,17 @@ The modern definition of neurosecretion has evolved to include the release of an Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball. Anatomical cluster that is a anterolateral part of the cranium and structurally supports the eye.[TAO] in FMA, this overlaps with bones such as the maxilla and sphenoid; in ZFA, individual bones are part of the orbit + + BTO:0004687 FMA:53074 GAID:223 MA:0002482 MESH:D009915 NCIT:C12347 + OpenCyc:Mx4rvW8EgZwpEbGdrcN5Y29ycA TAO:0001410 UMLS:C0029180 - Wikipedia:Orbit_(anatomy) XAO:0003171 ZFA:0001410 galen:Orbit @@ -261056,30 +75643,30 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA-abduced-lr + FMA-abduced-lr Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball. + + TAO:0001410 - Wikipedia:Orbit_(anatomy) - http://orcid.org/0000-0002-6601-2165 Anatomical cluster that is a anterolateral part of the cranium and structurally supports the eye.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001410 - TAO + TAO TAO:MAH in FMA, this overlaps with bones such as the maxilla and sphenoid; in ZFA, individual bones are part of the orbit - FMA + FMA @@ -261105,6 +75692,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -261131,20 +75719,19 @@ The modern definition of neurosecretion has evolved to include the release of an Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof. - Anatomical cluster that consists of the cartilages and bones that surround the brain.[TAO] neurocranial It includes the following bones: Ethmoid bone, Frontal bone, Occipital bone, Parietal bone, Sphenoid bone, Temporal bone. The term cranium can be ambiguous, in that it can refer to the neurocranium, or the neurocranium and the Facial skeleton The cartilaginous parts of the neurocranium undergo endochondral ossification in most species; ossification has been lost in cartilaginous fishes, but the cartilaginous condition of the skull of lampreys is considered to be primitive (Kardong, 1995)[PMID:11523816]. The neurocranium arises from paraxial mesoderm in the head (first five somites and the unsegmented somitomeres rostral to the first somite) and from ectoderm via the neural crest. In Chondrichthyes and other cartilaginous vertebrates this portion of the cranium does not ossify; it is not replaced via endochondral ossification[WP]. It seems MA uses 'neurocranium' as a synonym for chondrocranium. Note there are currently some structures part of both viscero and neurocranium - ethmoid, zyogomatic, ... + + AAO:0010153 EHDAA2:0000243 EMAPA:17681 FMA:53672 MA:0000317 - SCTID:361731002 TAO:0001580 - Wikipedia:Neuroranium XAO:0003170 ZFA:0001580 brain box @@ -261153,7 +75740,6 @@ The modern definition of neurosecretion has evolved to include the release of an brain pan braincase UBERON:0001703 - @@ -261163,37 +75749,37 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof. - PMID:11523816 + + TAO:MAH - Wikipedia:Neuroranium ZFA:0001580 Anatomical cluster that consists of the cartilages and bones that surround the brain.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001580 - TAO + TAO TAO:MAH The cartilaginous parts of the neurocranium undergo endochondral ossification in most species; ossification has been lost in cartilaginous fishes, but the cartilaginous condition of the skull of lampreys is considered to be primitive (Kardong, 1995)[PMID:11523816]. The neurocranium arises from paraxial mesoderm in the head (first five somites and the unsegmented somitomeres rostral to the first somite) and from ectoderm via the neural crest. In Chondrichthyes and other cartilaginous vertebrates this portion of the cranium does not ossify; it is not replaced via endochondral ossification[WP]. - WP + WP It seems MA uses 'neurocranium' as a synonym for chondrocranium. Note there are currently some structures part of both viscero and neurocranium - ethmoid, zyogomatic, ... - MA + MA @@ -261205,7 +75791,7 @@ The modern definition of neurosecretion has evolved to include the release of an brain pan - http://www.thefreedictionary.com/braincase + @@ -261279,6 +75865,9 @@ The modern definition of neurosecretion has evolved to include the release of an Skeletal and cartilage elements of the first pharyngeal arch.[TAO] There are cellular contributions from all three embryonic germ layers: pharyngeal mesoderm, endoderm and neural crest that migrates out of the ectoderm (Noden, 1983). in FMA, the jaw is an organism subdivision cluster, and includes mucosal tissue such as the gingiva as parts. It appears to be skeletal in MA (and has teeth as parts). It is reasonable to assume that ZFA and XAO consider the upper and lower jaws to be skeletal elements or clusters. EHDAA2 also considers these clusters. TODO - follow EHDAA2 model. These arbitrary differences in terminology and classification have to be reconciled with the genuine well-known biological differences in the skeletal elements across vertebrates + + + AAO:0000988 BTO:0001749 EMAPA:35455 @@ -261287,10 +75876,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001905 MESH:D007568 NCIT:C48821 - SCTID:181811001 + OpenCyc:Mx4rvVjjEZwpEbGdrcN5Y29ycA TAO:0001227 UMLS:C0022359 - Wikipedia:Jaw ZFA:0001227 galen:Jaw jaw @@ -261318,7 +75906,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -261329,29 +75917,29 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/The-neural-crest + Subdivision of skeleton which includes upper and lower jaw skeletons. - Wikipedia:Jaw - https://orcid.org/0000-0002-6601-2165 + + Skeletal and cartilage elements of the first pharyngeal arch.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001227 - TAO - ZFIN:curator + TAO + ZFIN:curator in FMA, the jaw is an organism subdivision cluster, and includes mucosal tissue such as the gingiva as parts. It appears to be skeletal in MA (and has teeth as parts). It is reasonable to assume that ZFA and XAO consider the upper and lower jaws to be skeletal elements or clusters. EHDAA2 also considers these clusters. TODO - follow EHDAA2 model. These arbitrary differences in terminology and classification have to be reconciled with the genuine well-known biological differences in the skeletal elements across vertebrates - FMA + FMA @@ -261426,15 +76014,15 @@ The modern definition of neurosecretion has evolved to include the release of an Superior maxillary arch located on the anterior and lateral sides of the skull.[AAO] Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG] Note isa/partof difference MA/FMA + + AAO:0000620 EHDAA2:0002118 EHDAA2:0004607 EHDAA:8025 EMAPA:17924 FMA:59399 - SCTID:362636001 VHOG:0000454 - Wikipedia:Upper_jaw ncithesaurus:Upper_Jaw maxillary part of mouth uberon @@ -261449,39 +76037,39 @@ The modern definition of neurosecretion has evolved to include the release of an See notes for jaw w.r.t skeletal element vs subdivision of head. upper jaw region - http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray189.png + http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray189.png Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]. - Wikipedia:Upper_jaw - http://orcid.org/0000-0002-6601-2165 + + Superior maxillary arch located on the anterior and lateral sides of the skull.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000620 - AAO - AAO:LAP + AAO + AAO:LAP Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000454 - VHOG + VHOG + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) - http://bgee.unil.ch/ Note isa/partof difference MA/FMA - MA + MA @@ -261555,6 +76143,8 @@ The modern definition of neurosecretion has evolved to include the release of an Inferior mandibular arch located on the anterior and lateral sides of the skull.[AAO] Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG] Note isa/partof difference MA/FMA + + AAO:0000272 EFO:0003660 EHDAA2:0001018 @@ -261562,9 +76152,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:17906 FMA:59398 MESH:D008334 - SCTID:362637005 VHOG:0000453 - Wikipedia:Lower_jaw ncithesaurus:Lower_Jaw mandibular part of mouth uberon @@ -261576,7 +76164,7 @@ The modern definition of neurosecretion has evolved to include the release of an See notes for jaw w.r.t skeletal element vs subdivision of head lower jaw region - http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png + http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png @@ -261587,38 +76175,38 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia:Mandibular_prominence + Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]. - Wikipedia:Lower_jaw + Inferior mandibular arch located on the anterior and lateral sides of the skull.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000272 - AAO - AAO:LAP + AAO + AAO:LAP Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000453 - VHOG + VHOG + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) - http://bgee.unil.ch/ Note isa/partof difference MA/FMA - MA + MA @@ -261663,10 +76251,11 @@ The modern definition of neurosecretion has evolved to include the release of an The groups of nerve cell bodies associated with the twelve cranial nerves. - Ganglion which is located in the head.[TAO] UBERON:0003213 UBERON:0026601 + + BIRNLEX:2597 BTO:0000106 EFO:0000902 @@ -261676,10 +76265,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000214 MAT:0000200 MIAA:0000200 - SCTID:244448001 TAO:0000013 VHOG:0000076 - Wikipedia:Cranial_nerve_ganglion XAO:0000027 ZFA:0000013 cranial ganglion @@ -261696,7 +76283,6 @@ The modern definition of neurosecretion has evolved to include the release of an presumptive cranial ganglia UBERON:0001714 - @@ -261706,19 +76292,19 @@ The modern definition of neurosecretion has evolved to include the release of an The groups of nerve cell bodies associated with the twelve cranial nerves. - ISBN:0-683-40008-8 - MGI:csmith + + ISBN:0-683-40008-8 + MGI:csmith MP:0001081 - PMID:9362461 Ganglion which is located in the head.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000013 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -261730,7 +76316,7 @@ The modern definition of neurosecretion has evolved to include the release of an cranial neural tree organ ganglion - OBOL:automatic + OBOL:automatic @@ -261742,7 +76328,7 @@ The modern definition of neurosecretion has evolved to include the release of an ganglion of cranial neural tree organ - OBOL:automatic + OBOL:automatic @@ -261768,6 +76354,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -261795,12 +76382,12 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical space that is enclosed by a pharynx. See notes for pharynx - as a grouping class this is probably too bad. We exclude WBbt:0005790 (pharyngeal lumen) because of the developmental relationship TOODO check + AAO:0010435 BSA:0000113 BTO:0002097 EMAPA:18381 FMA:54935 - SCTID:180543003 XAO:0000105 lumen of pharynx pharyngeal cavity @@ -261819,7 +76406,7 @@ The modern definition of neurosecretion has evolved to include the release of an - XAO + XAO @@ -261830,13 +76417,13 @@ The modern definition of neurosecretion has evolved to include the release of an - XAO + XAO An anatomical space that is enclosed by a pharynx. - OBOL:automatic + OBOL:automatic @@ -261872,6 +76459,9 @@ The modern definition of neurosecretion has evolved to include the release of an The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens. The part of the eyeball between the cornea and the iris, filled with aqueous humor. [TFD][VHOG] space in EHDAA2 - consider adding Cavity of anterior chamber of eyeball + + + BTO:0002084 EHDAA2:0000129 EHDAA:9033 @@ -261881,10 +76471,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000262 MESH:D000867 NCIT:C12667 - SCTID:181160009 UMLS:C0003151 VHOG:0001431 - Wikipedia:Anterior_chamber_of_eyeball anterior chamber anterior chamber of eye camera anterior @@ -261896,13 +76484,13 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0001766 anterior chamber of eyeball - http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg + http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg - FMA + FMA @@ -261915,17 +76503,17 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the eyeball between the cornea and the iris, filled with aqueous humor. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001431 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/anterior+chamber + VHOG + + space in EHDAA2 - consider adding Cavity of anterior chamber of eyeball - EHDAA2 + EHDAA2 @@ -261950,7 +76538,7 @@ The modern definition of neurosecretion has evolved to include the release of an camera anterior bulbi oculi - Wikipedia:Anterior_chamber_of_eyeball + @@ -262002,6 +76590,9 @@ The modern definition of neurosecretion has evolved to include the release of an TODO - check child terms, isa vs partof. See also MA:0001284 ! tunica vasculosa plexus uveal + + + CALOHA:TS-2228 EMAPA:35901 FMA:58103 @@ -262009,9 +76600,7 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002480 MESH:D014602 NCIT:C12811 - SCTID:280648000 UMLS:C0042160 - Wikipedia:Uvea tunica vasculosa of eyeball uvea uveal tract @@ -262024,26 +76613,26 @@ The modern definition of neurosecretion has evolved to include the release of an uvea - http://upload.wikimedia.org/wikipedia/commons/e/eb/Gray869.png + http://upload.wikimedia.org/wikipedia/commons/e/eb/Gray869.png - FMA + FMA The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]. + MP:0005197 - Wikipedia:Uvea - DOI:10.1177/0192623311409597 + @@ -262073,19 +76662,19 @@ The modern definition of neurosecretion has evolved to include the release of an pars iridica retinae - Wikipedia:Uvea + tunica vasculatis oculi - Wikipedia:Uvea + tunica vasculosa bulbi - Wikipedia:Uvea + @@ -262126,6 +76715,9 @@ The modern definition of neurosecretion has evolved to include the release of an The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] iridial The avian iris and ciliary body undergoes a transition from smooth-to-striated muscle during embryonic development [DOI:dx.doi.org/10.1006/dbio.1998.9019] + + + AAO:0010347 BTO:0000653 CALOHA:TS-0491 @@ -262137,11 +76729,10 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000273 MESH:D007498 NCIT:C12737 - SCTID:181164000 + OpenCyc:Mx4rvVjbppwpEbGdrcN5Y29ycA TAO:0001238 UMLS:C0022077 VHOG:0000101 - Wikipedia:Iris_(anatomy) XAO:0000185 ZFA:0001238 uberon @@ -262165,33 +76756,33 @@ The modern definition of neurosecretion has evolved to include the release of an - XAO + XAO The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0001322 The opaque muscular contractile diaphragm suspended in the aqueous humour in front of the lens of the eye. The organ is perforated by the pupil and continues peripherally with the ciliary body. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000101 - VHOG - http://bgee.unil.ch/ + VHOG + The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000101 - VHOG + VHOG + DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007) - http://bgee.unil.ch/ @@ -262203,14 +76794,14 @@ The modern definition of neurosecretion has evolved to include the release of an irides - + irises VHOG:0000101 - + @@ -262260,6 +76851,9 @@ The modern definition of neurosecretion has evolved to include the release of an Portion of tissue comprised of four to six layers of nonkeratinized, stratified squamous cells and represents approximately 60% of the thickness of the cornea.[TAO] In Humans: It consists of several layers of cells. The cells of the deepest layer are columnar; then follow two or three layers of polyhedral cells, the majority of which are prickle cells similar to those found in the stratum mucosum of the cuticle. Lastly, there are three or four layers of squamous cells, with flattened nuclei In zebrafish: nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals + + + BTO:0000287 CALOHA:TS-0173 EFO:0001917 @@ -262270,10 +76864,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001243 MESH:D019573 NCIT:C12928 - SCTID:368825001 TAO:0002187 UMLS:C0459875 - Wikipedia:Corneal_epithelium ZFA:0001683 anterior corneal epithelium cornea epithelial tissue @@ -262298,7 +76890,7 @@ The modern definition of neurosecretion has evolved to include the release of an corneal epithelium - http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png + http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png @@ -262316,16 +76908,16 @@ The modern definition of neurosecretion has evolved to include the release of an The smooth stratified squamous epithelium that covers the outer surface of the cornea. MESH:A09.371.060.217.325 - MGI:smb + MGI:smb MP:0006000 Portion of tissue comprised of four to six layers of nonkeratinized, stratified squamous cells and represents approximately 60% of the thickness of the cornea.[TAO] - 2012-08-14 + 2012-08-14 TAO:0002187 - TAO + TAO ZFIN:ZDB-PUB-061010-3 @@ -262338,26 +76930,26 @@ The modern definition of neurosecretion has evolved to include the release of an cornea epithelial tissue - OBOL:automatic + OBOL:automatic cornea epithelium - OBOL:automatic + OBOL:automatic epithelial tissue of cornea - OBOL:automatic + OBOL:automatic epithelium anterius corneae FMA:58263 - FMA:TA + FMA:TA @@ -262370,7 +76962,7 @@ The modern definition of neurosecretion has evolved to include the release of an e. anterius corneae - Wikipedia:Corneal_epithelium + @@ -262442,7 +77034,6 @@ The modern definition of neurosecretion has evolved to include the release of an Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]. - The sclera, also known as the white part of the eye, is the opaque (usually white, though certain animals, such as horses and lizards, can have black sclera), fibrous, protective, outer layer of the eye containing collagen and elastic fiber. It is derived from the neural crest. In children, it is thinner and shows some of the underlying pigment, appearing slightly blue. In the elderly, however, fatty deposits on the sclera can make it appear slightly yellow. The sclera forms the posterior five sixths of the connective tissue coat of the globe. It is continuous with the dura mater and the cornea, and maintains the shape of the globe, offering resistance to internal and external forces, and provides an attachment for the extraocular muscle insertions. The sclera is perforated by plenty of nerves and vessels passing through the posterior scleral foramen, the hole that is formed by the optic nerve. At the optic disk the outer two-thirds of the sclera continues with the dura mater (outer coat of the brain) via the dural sheath of the optic nerve. The inner third joins with some choroidal tissue to form a plate (lamina cribrosa) across the optic nerve with perforations through which the optic fibers (fasciculi). The thickness of the sclera varies from 1mm at the posterior pole to 0.3 mm just behind the rectus muscle insertions. The sclera's blood vessels are mainly on the surface, and together with the conjunctiva (which lies on top) This is a thin layer covering the sclera. Along with the vessels of the conjunctiva, those of the sclera renders the inflamed eye bright red. [WP,unvetted][Wikipedia:Sclera]. The tough, usually white, outer coat of the eyeball, covering all the posterior surface and continuous anteriorly with the cornea. [TFD][VHOG] scleral @@ -262450,6 +77041,9 @@ The modern definition of neurosecretion has evolved to include the release of an continuous with the dura mater and the cornea; The sclera forms the posterior five-sixths of the connective tissue coat of the globe. Majority derives from NC that surrounds optic cup of neurectoderm; a small temporal portion develops from the mesoderm that contributes to striated extra-ocular muscles and vascular endothelia[Rada&Johnson]. Seko et al demonstrate chondrogenic potential and identify this as connective tissue[DOI:10.1371/journal.pone.0003709]. + + + AAO:0010354 BTO:0001606 EMAPA:19027 @@ -262459,22 +77053,20 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000280 MESH:D012590 NCIT:C12784 - SCTID:181163006 + OpenCyc:Mx4rv7yR55wpEbGdrcN5Y29ycA UMLS:C0036410 VHOG:0001274 - Wikipedia:Sclera XAO:0000183 ZFA:0005563 uberon scleral capsule UBERON:0001773 - Disease notes: implicated in rheumatoid arthritis. sclera - http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg + http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg @@ -262485,7 +77077,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -262496,7 +77088,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -262520,30 +77112,30 @@ The modern definition of neurosecretion has evolved to include the release of an cjm ISBN:0781772214 - Wikipedia + Wikipedia Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]. - Wikipedia:Sclera + ZFIN:ZDB-PUB-050701-15 The sclera, also known as the white part of the eye, is the opaque (usually white, though certain animals, such as horses and lizards, can have black sclera), fibrous, protective, outer layer of the eye containing collagen and elastic fiber. It is derived from the neural crest. In children, it is thinner and shows some of the underlying pigment, appearing slightly blue. In the elderly, however, fatty deposits on the sclera can make it appear slightly yellow. The sclera forms the posterior five sixths of the connective tissue coat of the globe. It is continuous with the dura mater and the cornea, and maintains the shape of the globe, offering resistance to internal and external forces, and provides an attachment for the extraocular muscle insertions. The sclera is perforated by plenty of nerves and vessels passing through the posterior scleral foramen, the hole that is formed by the optic nerve. At the optic disk the outer two-thirds of the sclera continues with the dura mater (outer coat of the brain) via the dural sheath of the optic nerve. The inner third joins with some choroidal tissue to form a plate (lamina cribrosa) across the optic nerve with perforations through which the optic fibers (fasciculi). The thickness of the sclera varies from 1mm at the posterior pole to 0.3 mm just behind the rectus muscle insertions. The sclera's blood vessels are mainly on the surface, and together with the conjunctiva (which lies on top) This is a thin layer covering the sclera. Along with the vessels of the conjunctiva, those of the sclera renders the inflamed eye bright red. [WP,unvetted][Wikipedia:Sclera]. - Wikipedia:Sclera + The tough, usually white, outer coat of the eyeball, covering all the posterior surface and continuous anteriorly with the cornea. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001274 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/sclera + VHOG + + @@ -262615,13 +77207,13 @@ The modern definition of neurosecretion has evolved to include the release of an - prolog + prolog A skeletal muscle organ that is part of the trunk region. - http://orcid.org/0000-0002-6601-2165 + @@ -262639,25 +77231,25 @@ The modern definition of neurosecretion has evolved to include the release of an muscle organ of torso - OBOL:automatic + OBOL:automatic muscle organ of trunk - OBOL:automatic + OBOL:automatic torso muscle organ - OBOL:automatic + OBOL:automatic trunk muscle organ - OBOL:automatic + OBOL:automatic @@ -262700,6 +77292,9 @@ The modern definition of neurosecretion has evolved to include the release of an The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes. The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] + + + AAO:0010341 BTO:0000260 CALOHA:TS-0694 @@ -262710,10 +77305,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000264 MESH:D002924 NCIT:C12345 - SCTID:263340007 UMLS:C0008779 VHOG:0000102 - Wikipedia:Ciliary_body XAO:0000186 neuronames:1571 ocular ciliary body @@ -262727,7 +77320,7 @@ The modern definition of neurosecretion has evolved to include the release of an ciliary body - http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg + http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg @@ -262744,19 +77337,19 @@ The modern definition of neurosecretion has evolved to include the release of an The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes. - ISBN:0-683-40008-8 + + ISBN:0-683-40008-8 MP:0005099 - Wikipedia:Ciliary_body The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000102 - VHOG + VHOG + DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007) - http://bgee.unil.ch/ @@ -262769,13 +77362,19 @@ The modern definition of neurosecretion has evolved to include the release of an ciliary bodies VHOG:0000102 - + + + + + + corpus ciliare + corpus ciliare - Wikipedia:Ciliary_body + @@ -262833,6 +77432,9 @@ The modern definition of neurosecretion has evolved to include the release of an choroidal MP treats posterior uvea and optic choroid as distinct + + + BTO:0001829 CALOHA:TS-2054 EMAPA:19077 @@ -262842,11 +77444,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000263 MESH:D002829 NCIT:C12344 - SCTID:181172003 TAO:0005229 UMLS:C0008520 VHOG:0001568 - Wikipedia:Choroid ZFA:0005229 choroid choroid coat @@ -262863,7 +77463,7 @@ The modern definition of neurosecretion has evolved to include the release of an optic choroid - http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg + http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg @@ -262874,7 +77474,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -262885,19 +77485,19 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia - lexical + lexical Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]. - Wikipedia:Choroid + @@ -262921,13 +77521,13 @@ The modern definition of neurosecretion has evolved to include the release of an choroid coat - Wikipedia:Choroid + choroidea - Wikipedia:Choroid + @@ -262939,7 +77539,7 @@ The modern definition of neurosecretion has evolved to include the release of an posterior uvea - Wikipedia:Uvea#Regions + @@ -262951,7 +77551,7 @@ The modern definition of neurosecretion has evolved to include the release of an choroidea - Wikipedia:Choroid + @@ -263014,6 +77614,9 @@ The modern definition of neurosecretion has evolved to include the release of an relationship type change: subclass tissue (CARO:0000043) CHANGED TO: develops_from tissue (UBERON:0000479)[TAO] relationship type change: subclass tissue (CARO:0000043) CHANGED TO: has_developmental_contribution_from tissue (UBERON:0000479)[TAO] substantia propria + + + CALOHA:TS-1138 EFO:0002514 EMAPA:17602 @@ -263022,10 +77625,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001245 MESH:D003319 NCIT:C12699 - SCTID:362511000 TAO:0002189 UMLS:C0010040 - Wikipedia:Corneal_stroma ZFA:0001685 corneal stroma stroma of cornea @@ -263037,7 +77638,7 @@ The modern definition of neurosecretion has evolved to include the release of an substantia propria of cornea - http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png + http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png @@ -263050,13 +77651,13 @@ The modern definition of neurosecretion has evolved to include the release of an cjm ISBN:0781772214 - Wikipedia + Wikipedia The lamellated connective tissue of the cornea between the Bowman and Descemet membranes. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MESH:A09.371.060.217.228 MP:0005300 @@ -263064,26 +77665,26 @@ The modern definition of neurosecretion has evolved to include the release of an Portion of tissue that is located basal to Bowman's layer and distal to Descemet's membrane and is comprised largely of connective tissue.[TAO] - 2012-08-14 + 2012-08-14 TAO:0002189 - TAO + TAO ZFIN:ZDB-PUB-061010-3 relationship type change: subclass tissue (CARO:0000043) CHANGED TO: develops_from tissue (UBERON:0000479)[TAO] - 2012-08-14 + 2012-08-14 TAO:0002189 - TAO + TAO relationship type change: subclass tissue (CARO:0000043) CHANGED TO: has_developmental_contribution_from tissue (UBERON:0000479)[TAO] - 2012-08-14 + 2012-08-14 TAO:0002189 - TAO + TAO @@ -263102,7 +77703,7 @@ The modern definition of neurosecretion has evolved to include the release of an substantia propria corneae FMA:58306 - FMA:TA + FMA:TA @@ -263144,15 +77745,16 @@ The modern definition of neurosecretion has evolved to include the release of an A double layer covering the ciliary body that produces aqueous humor. + + + BTO:0001770 CALOHA:TS-0695 EMAPA:35239 FMA:58464 MA:0001238 NCIT:C32314 - SCTID:280870004 UMLS:C0459736 - Wikipedia:Ciliary_body#Ciliary_epithelium ciliary body epithelium epithelium of ciliary body ocular ciliary epithelium @@ -263165,7 +77767,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -263176,7 +77778,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -263187,7 +77789,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MP + MP @@ -263198,13 +77800,13 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia A double layer covering the ciliary body that produces aqueous humor. - Wikipedia:Ciliary_body#Ciliary_epithelium + @@ -263256,11 +77858,11 @@ The modern definition of neurosecretion has evolved to include the release of an The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae. + + EMAPA:35451 FMA:58526 MA:0002777 - SCTID:280882008 - Wikipedia:Iris_stroma ZFA:0005569 iridial stroma stroma of iris @@ -263270,14 +77872,14 @@ The modern definition of neurosecretion has evolved to include the release of an iris stroma - http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png + http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae. - Wikipedia:Iris_stroma - http://www.drugs.com/dict/stroma-of-iris.html + + @@ -263318,6 +77920,9 @@ The modern definition of neurosecretion has evolved to include the release of an The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]. Any of the paired nerves emerging from the spinal cord, each attached to the cord by two roots: ventral and dorsal, and passing out between the vertebrae. [TFD][VHOG] + + + AAO:0011101 BAMS:spin BTO:0000870 @@ -263328,10 +77933,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000233 MESH:D013127 NCIT:C12792 - SCTID:361099009 + OpenCyc:Mx4rwK_iFJwpEbGdrcN5Y29ycA UMLS:C0037941 VHOG:0000824 - Wikipedia:Spinal_nerve XAO:0003101 neuronames:1228 backbone nerve @@ -263351,7 +77955,7 @@ The modern definition of neurosecretion has evolved to include the release of an spinal nerve - https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg + https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg @@ -263364,11 +77968,11 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the paired nerves emerging from the spinal cord, each attached to the cord by two roots: ventral and dorsal, and passing out between the vertebrae. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000824 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/spinal+nerve + VHOG + + @@ -263380,55 +77984,55 @@ The modern definition of neurosecretion has evolved to include the release of an backbone nerve - OBOL:automatic + OBOL:automatic nerve of backbone - OBOL:automatic + OBOL:automatic nerve of spinal column - OBOL:automatic + OBOL:automatic nerve of spine - OBOL:automatic + OBOL:automatic nerve of vertebral column - OBOL:automatic + OBOL:automatic spinal column nerve - OBOL:automatic + OBOL:automatic spine nerve - OBOL:automatic + OBOL:automatic vertebral column nerve - OBOL:automatic + OBOL:automatic nervi spinales - Wikipedia:Spinal_nerve + @@ -263436,7 +78040,7 @@ The modern definition of neurosecretion has evolved to include the release of an spinal nerves BAMS:spin - + @@ -263444,7 +78048,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -263460,12 +78063,13 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the layers that make up the retina[MP]. MA does not treat internal/external limiting memranes as layers - these are classified as laminae. Here we follow other ontologies in grouping with other layers. MA also treats retinal pigment epithelium and neural retina epithelium as distinct from the layers. We follow ontologies such as FMA and ZFA in first dividing into pigmented and neural layers - these are also classified as layers, giving us over the usual 10 layers + + AAO:0010353 EMAPA:35742 FMA:58617 MA:0001319 NCIT:C49328 - SCTID:280657006 UMLS:C0459649 XAO:0000266 retina layer @@ -263488,7 +78092,7 @@ The modern definition of neurosecretion has evolved to include the release of an MA does not treat internal/external limiting memranes as layers - these are classified as laminae. Here we follow other ontologies in grouping with other layers. MA also treats retinal pigment epithelium and neural retina epithelium as distinct from the layers. We follow ontologies such as FMA and ZFA in first dividing into pigmented and neural layers - these are also classified as layers, giving us over the usual 10 layers - MA + MA @@ -263567,6 +78171,10 @@ The modern definition of neurosecretion has evolved to include the release of an Twelve pairs of cranial nerves exit/enter the cranium through openings in the skull. The nerves contain efferent axons with motor and glandular functions, as well as afferent axons from cranial ganglia with sensory functions. The nerves are numbered in a rostral to caudal sequence, with the exception of the lateral line nerves.[TAO] We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...).[well established][VHOG] See https://github.com/obophenotype/mouse-anatomy-ontology/issues/6 + + + + AAO:0000108 BAMS:cran BIRNLEX:1623 @@ -263580,12 +78188,11 @@ The modern definition of neurosecretion has evolved to include the release of an MBA:967 MESH:D003391 NCIT:C12700 - SCTID:244447006 + OpenCyc:Mx4rvWvJVpwpEbGdrcN5Y29ycA TAO:0000641 UMLS:C0010268 UMLS:C1269897 VHOG:0000279 - Wikipedia:Cranial_nerve XAO:0000429 XAO:0003089 ZFA:0000641 @@ -263600,39 +78207,44 @@ The modern definition of neurosecretion has evolved to include the release of an cranial nerve - http://upload.wikimedia.org/wikipedia/commons/1/18/Brain_human_normal_inferior_view_with_labels_en-2.svg - http://upload.wikimedia.org/wikipedia/commons/8/84/Brain_human_normal_inferior_view_with_labels_en.svg + http://upload.wikimedia.org/wikipedia/commons/1/18/Brain_human_normal_inferior_view_with_labels_en-2.svg + http://upload.wikimedia.org/wikipedia/commons/8/84/Brain_human_normal_inferior_view_with_labels_en.svg Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord. - Wikipedia:Cranial_nerve + Twelve pairs of cranial nerves exit/enter the cranium through openings in the skull. The nerves contain efferent axons with motor and glandular functions, as well as afferent axons from cranial ganglia with sensory functions. The nerves are numbered in a rostral to caudal sequence, with the exception of the lateral line nerves.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000641 - TAO - ZFIN:curator + TAO + ZFIN:curator We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000279 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 - http://bgee.unil.ch/ UMLS:C0010268 BIRNLEX:1623 + + + + + UMLS:C0010268 ncithesaurus:Cranial_Nerve @@ -263645,7 +78257,7 @@ The modern definition of neurosecretion has evolved to include the release of an nervus cranialis - Wikipedia:Cranial_nerve + @@ -263678,6 +78290,9 @@ The modern definition of neurosecretion has evolved to include the release of an The fluid produced by the ciliary process in the eye and occupying the anterior and posterior chambers. It provides nourishment for the lens and cornea and maintains the ocular pressure, and hence the optical integrity of the eyeball. [TFD][VHOG] (...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG] FMA says A+P chambers, and MA states A chamber. ZFA states A chamber and tha it is produced primarily by dorsal ciliary epithelial cells.To be investigated across taxa. + + + EHDAA2:0000139 EHDAA:10196 EMAPA:18232 @@ -263687,10 +78302,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001236 MESH:D001082 NCIT:C13190 - SCTID:280587006 + OpenCyc:Mx4rvdGd-5wpEbGdrcN5Y29ycA UMLS:C0003662 VHOG:0000548 - Wikipedia:Aqueous_humor ZFA:0005564 aqueous humor aqueous humour @@ -263701,7 +78315,7 @@ The modern definition of neurosecretion has evolved to include the release of an aqueous humor of eyeball - http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg + http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg @@ -263714,39 +78328,39 @@ The modern definition of neurosecretion has evolved to include the release of an FMA def states A and P located_in in EHDAA2 - VHOG + VHOG A thick watery refractive medium that fills the space between the lens and the cornea[WP]. - Wikipedia:Aqueous_humor + The fluid produced by the ciliary process in the eye and occupying the anterior and posterior chambers. It provides nourishment for the lens and cornea and maintains the ocular pressure, and hence the optical integrity of the eyeball. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000548 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/aqueous+humour + VHOG + + (...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000548 - VHOG + VHOG + DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24 - http://bgee.unil.ch/ FMA says A+P chambers, and MA states A chamber. ZFA states A chamber and tha it is produced primarily by dorsal ciliary epithelial cells.To be investigated across taxa. - FMA + FMA @@ -263765,7 +78379,7 @@ The modern definition of neurosecretion has evolved to include the release of an humor aquosus FMA:58819 - FMA:TA + FMA:TA @@ -263799,7 +78413,7 @@ The modern definition of neurosecretion has evolved to include the release of an The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells. - + AEO:0001000 BTO:0005630 EMAPA:36596 @@ -263811,7 +78425,6 @@ The modern definition of neurosecretion has evolved to include the release of an ganglion sensorium uberon UBERON:0001800 - sensory ganglion @@ -263862,14 +78475,15 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive). + + + EMAPA:36594 FMA:58865 MA:0002484 MESH:D000869 NCIT:C12668 - SCTID:280658001 UMLS:C0003153 - Wikipedia:Anterior_segment_of_eyeball ZFA:0005566 anterior eye segment anterior segment eye @@ -263883,7 +78497,7 @@ The modern definition of neurosecretion has evolved to include the release of an anterior segment of eyeball - http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png + http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png @@ -263894,7 +78508,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -263905,19 +78519,19 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm - lexical + lexical Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive). - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MESH:A09.371.060 MP:0005193 @@ -263926,7 +78540,7 @@ The modern definition of neurosecretion has evolved to include the release of an ZFA - https://github.com/obophenotype/uberon/issues/378 + pending @@ -263945,7 +78559,7 @@ The modern definition of neurosecretion has evolved to include the release of an segmentum anterius bulbi oculi - Wikipedia:Anterior_segment_of_eyeball + @@ -263975,13 +78589,14 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive). + + + EMAPA:36595 FMA:58868 MA:0002485 NCIT:C12906 - SCTID:280659009 UMLS:C0278450 - Wikipedia:Posterior_segment_of_eyeball ZFA:0005567 eye posterior segment posterior eye segment @@ -263995,7 +78610,7 @@ The modern definition of neurosecretion has evolved to include the release of an posterior segment of eyeball - http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg + http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg @@ -264006,7 +78621,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -264017,19 +78632,19 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm - lexical + lexical Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive). - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0005195 @@ -264048,7 +78663,7 @@ The modern definition of neurosecretion has evolved to include the release of an segmentum posterius bulbi oculi - Wikipedia:Posterior_segment_of_eyeball + @@ -264085,14 +78700,14 @@ The modern definition of neurosecretion has evolved to include the release of an A layer of epithelial cells that is part of the eye. this class is the superclass of the anterior epithelium and equatorial epithlium, although the term 'lens epithelium' may refer specifically to the former + + BTO:0001873 CALOHA:TS-0543 EMAPA:32871 FMA:58871 MA:0001301 - SCTID:362523006 TAO:0001326 - Wikipedia:Lens_(anatomy)#Lens_Epithelium XAO:0004094 ZFA:0001326 epithelial tissue of eye lens @@ -264114,51 +78729,51 @@ The modern definition of neurosecretion has evolved to include the release of an A layer of epithelial cells that is part of the eye. - http://orcid.org/0000-0002-6601-2165 + epithelial tissue of eye lens - OBOL:automatic + OBOL:automatic epithelial tissue of lens - OBOL:automatic + OBOL:automatic epithelium lentis FMA:58871 - FMA:TA + FMA:TA epithelium of eye lens - OBOL:automatic + OBOL:automatic eye lens epithelial tissue - OBOL:automatic + OBOL:automatic eye lens epithelium - OBOL:automatic + OBOL:automatic lens epithelial tissue - OBOL:automatic + OBOL:automatic @@ -264177,9 +78792,9 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -264227,15 +78842,16 @@ The modern definition of neurosecretion has evolved to include the release of an (...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG] synthesized by the lens epithelium and its main components are Type IV collagen and sulfated glycosaminoglycans (GAGs). [Wikipedia:Capsule_of_lens FMA classifies this is a capsule and hence an organ part. In contrast we classify this as acellular + + + EHDAA2:0000977 EMAPA:18237 FMA:58881 MA:0001300 NCIT:C32975 - SCTID:244500004 UMLS:C0229232 VHOG:0000550 - Wikipedia:Lens_(anatomy)#Lens_capsule ZFA:0005574 capsula lentis lens capsule @@ -264245,7 +78861,7 @@ The modern definition of neurosecretion has evolved to include the release of an capsule of lens - http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png + http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png @@ -264256,7 +78872,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia @@ -264267,40 +78883,40 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 The elastic, clear, membrane-like structure, that is outer most layer of the lens. - MGI:smb + + MGI:smb MP:0003236 - PMID:15483628 The transparent membrane which surrounds the lens of the eye. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000550 - VHOG - http://bgee.unil.ch/ + VHOG + (...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000550 - VHOG + VHOG + DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24 - http://bgee.unil.ch/ FMA classifies this is a capsule and hence an organ part. In contrast we classify this as acellular - FMA + FMA @@ -264351,7 +78967,8 @@ The modern definition of neurosecretion has evolved to include the release of an Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion. - + + AEO:0001001 CALOHA:TS-2340 EMAPA:17157 @@ -264361,7 +78978,6 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D005725 NCIT:C12720 UMLS:C0017068 - Wikipedia:Autonomic_ganglion autonomic nervous system ganglion ganglion of autonomic nervous system ganglion of visceral nervous system @@ -264369,16 +78985,15 @@ The modern definition of neurosecretion has evolved to include the release of an uberon ganglion autonomicum UBERON:0001805 - autonomic ganglion - http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png + http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion. - Wikipedia:Autonomic_ganglion + @@ -264390,31 +79005,31 @@ The modern definition of neurosecretion has evolved to include the release of an autonomic nervous system ganglion - OBOL:automatic + OBOL:automatic ganglion of autonomic nervous system - OBOL:automatic + OBOL:automatic ganglion of visceral nervous system - OBOL:automatic + OBOL:automatic visceral nervous system ganglion - OBOL:automatic + OBOL:automatic ganglion autonomicum - Wikipedia:Autonomic_ganglion + @@ -264461,6 +79076,9 @@ The modern definition of neurosecretion has evolved to include the release of an A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia. + + + AAO:0010773 BTO:0001333 CALOHA:TS-0994 @@ -264470,9 +79088,7 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000226 MESH:D005728 NCIT:C12467 - SCTID:362485003 UMLS:C0017071 - Wikipedia:Sympathetic_ganglion ganglion of sympathetic nervous system ganglion of sympathetic part of autonomic division of nervous system ganglion sympatheticum @@ -264484,7 +79100,7 @@ The modern definition of neurosecretion has evolved to include the release of an sympathetic ganglion - http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png + http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png @@ -264495,15 +79111,15 @@ The modern definition of neurosecretion has evolved to include the release of an - DOI:10.1101/gr.157586.113 - ISBN:0073040584 + + ISBN:0073040584 A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia. + MP:0001008 - http://orcid.org/0000-0002-6601-2165 @@ -264515,40 +79131,46 @@ The modern definition of neurosecretion has evolved to include the release of an ganglion of sympathetic nervous system - OBOL:automatic + OBOL:automatic ganglion of sympathetic part of autonomic division of nervous system - OBOL:automatic + OBOL:automatic sympathetic nervous system ganglion - OBOL:automatic + OBOL:automatic sympathetic part of autonomic division of nervous system ganglion - OBOL:automatic + OBOL:automatic ganglion sympathicum - BTO:0001333 - Wikipedia:Sympathetic_ganglion + + + + + ganglion sympathicum + BTO:0001333 + + @@ -264588,6 +79210,9 @@ The modern definition of neurosecretion has evolved to include the release of an Surface structure that is one of the two fleshy folds surrounding the opening of the mouth.[TAO] labial + + + BTO:0001647 CALOHA:TS-0558 EMAPA:32839 @@ -264596,11 +79221,10 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000343 MESH:D008046 NCIT:C12220 - SCTID:181221003 + OpenCyc:Mx4rvVi4U5wpEbGdrcN5Y29ycA TAO:0007006 UMLS:C0023759 VHOG:0000677 - Wikipedia:Lip ZFA:0007006 galen:Lip uberon @@ -264611,14 +79235,14 @@ The modern definition of neurosecretion has evolved to include the release of an lip - http://upload.wikimedia.org/wikipedia/commons/9/90/Lips.JPG - http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg + http://upload.wikimedia.org/wikipedia/commons/9/90/Lips.JPG + http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg - ZFA + ZFA @@ -264629,10 +79253,10 @@ The modern definition of neurosecretion has evolved to include the release of an - BTO + BTO FMA-implicit - VHOG - ZFA + VHOG + ZFA @@ -264643,24 +79267,24 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm One of the two fleshy folds which surround the opening of the mouth. - Wikipedia:Lip - http://www.medterms.com/script/main/art.asp?articlekey=9458 + + Surface structure that is one of the two fleshy folds surrounding the opening of the mouth.[TAO] - 2012-08-14 + 2012-08-14 TAO:0007006 - TAO - ZFIN:curator - http//:www.medterms.com/script/main/art.asp?articlekey=9458 + TAO + + ZFIN:curator @@ -264672,7 +79296,7 @@ The modern definition of neurosecretion has evolved to include the release of an labia oris - Wikipedia:Lip + @@ -264693,6 +79317,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -264715,13 +79340,14 @@ The modern definition of neurosecretion has evolved to include the release of an Lip that covers the lower portion of the mouth. [ZFIN:Curator][VHOG] Lip that covers the upper portion of the mouth.[TAO] UBERON:0003391 + + EMAPA:17925 FMA:59817 MA:0000919 - SCTID:245776003 + OpenCyc:Mx4rvWPv7pwpEbGdrcN5Y29ycA TAO:0001970 VHOG:0001750 - Wikipedia:Upper_lip ZFA:0005226 upper jaw lip uberon @@ -264731,44 +79357,44 @@ The modern definition of neurosecretion has evolved to include the release of an upper lip - http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg + http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg Lip that covers the upper portion of the mouth.[TAO]. + TAO:0001970 - Wikipedia:Upper_lip Lip that covers the lower portion of the mouth. [ZFIN:Curator][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001750 - VHOG - http://bgee.unil.ch/ + VHOG + Lip that covers the upper portion of the mouth.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001970 - TAO - TAO:wd + TAO + TAO:wd upper jaw lip - https://orcid.org/0000-0002-6601-2165 + labium superius oris - Wikipedia:Upper_lip + @@ -264789,6 +79415,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -264804,15 +79431,17 @@ The modern definition of neurosecretion has evolved to include the release of an Lip that covers the lower portion of the mouth.[TAO]. Lip that covers the lower portion of the mouth.[TAO] UBERON:0003392 + + + EHDAA2:0001020 EMAPA:17909 FMA:59818 MA:0000921 NCIT:C94572 - SCTID:245777007 + OpenCyc:Mx4rv842UpwpEbGdrcN5Y29ycA TAO:0002060 UMLS:C0458583 - Wikipedia:Lower_lip ZFA:0005225 lower jaw lip uberon @@ -264822,23 +79451,23 @@ The modern definition of neurosecretion has evolved to include the release of an lower lip - http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg + http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg Lip that covers the lower portion of the mouth.[TAO]. + TAO:0002060 - Wikipedia:Lower_lip Lip that covers the lower portion of the mouth.[TAO] - 2012-08-14 + 2012-08-14 TAO:0002060 - TAO - TAO:wd + TAO + TAO:wd @@ -264850,13 +79479,13 @@ The modern definition of neurosecretion has evolved to include the release of an lower jaw lip - https://orcid.org/0000-0002-6601-2165 + labium inferius oris - Wikipedia:Lower_lip + @@ -264870,13 +79499,14 @@ The modern definition of neurosecretion has evolved to include the release of an - + + @@ -264891,7 +79521,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -264904,6 +79534,9 @@ The modern definition of neurosecretion has evolved to include the release of an A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium. A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium. [TFD][VHOG] + + + BAMS:phn BTO:0001063 EHDAA:4677 @@ -264913,10 +79546,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001170 MESH:D010791 NCIT:C52813 - SCTID:280344009 + OpenCyc:Mx4rvtmdUJwpEbGdrcN5Y29ycA UMLS:C0031774 VHOG:0000728 - Wikipedia:Phrenic_nerve uberon diaphragmatic nerve nervus phrenicus @@ -264926,7 +79558,7 @@ The modern definition of neurosecretion has evolved to include the release of an phrenic nerve - http://upload.wikimedia.org/wikipedia/commons/3/3c/Gray806.png + http://upload.wikimedia.org/wikipedia/commons/3/3c/Gray806.png @@ -264938,11 +79570,11 @@ The modern definition of neurosecretion has evolved to include the release of an A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000728 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/phrenic+nerve + VHOG + + @@ -264960,10 +79592,15 @@ The modern definition of neurosecretion has evolved to include the release of an nervus phrenicus - BTO:0001063 - Wikipedia:Phrenic_nerve + + + + + nervus phrenicus + BTO:0001063 + @@ -265019,6 +79656,9 @@ The modern definition of neurosecretion has evolved to include the release of an mesencephalic part of brainstem in ABA - we reject this in favor of ISBN:0471888893 which has an implicit overlaps relationships MB + + + AAO:0010149 BAMS:MES BIRNLEX:1667 @@ -265040,12 +79680,11 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D008636 MIAA:0000106 NCIT:C12510 + OpenCyc:Mx4rvsBUqpwpEbGdrcN5Y29ycA RETIRED_EHDAA2:0001104 - SCTID:279099009 TAO:0000128 UMLS:C0025462 VHOG:0000069 - Wikipedia:Midbrain XAO:0000014 ZFA:0000128 neuronames:462 @@ -265058,7 +79697,7 @@ The modern definition of neurosecretion has evolved to include the release of an midbrain - http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG + http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG @@ -265069,7 +79708,7 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional @@ -265080,7 +79719,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN @@ -265094,7 +79733,7 @@ The modern definition of neurosecretion has evolved to include the release of an ZFA https://github.com/obophenotype/uberon/issues/378 - ABA + ABA pending @@ -265102,56 +79741,61 @@ The modern definition of neurosecretion has evolved to include the release of an ZFA - ABA + ABA pending Middle part of the brain composed of the optic tectum and penducular region.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010149 - AAO - AAO:BJB + AAO + AAO:BJB The brain region between the forebrain anteriorly and the hindbrain posteriorly, including the tectum dorsally and the midbrain tegmentum ventrally. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000128 - TAO - ZFIN:curator + TAO + ZFIN:curator Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000069 - VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) - http://bgee.unil.ch/ + VHOG + + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) part of brainstem in ABA - we reject this in favor of ISBN:0471888893 which has an implicit overlaps relationships - ABA + ABA MB BIRNLEX:1667 - NIFSTD:NeuroNames_abbrevSource - + NIFSTD:NeuroNames_abbrevSource + UMLS:C0025462 BIRNLEX:1667 + + + + + UMLS:C0025462 ncithesaurus:Mesencephalon @@ -265164,7 +79808,7 @@ The modern definition of neurosecretion has evolved to include the release of an mesencephalon - Wikipedia:Midbrain + @@ -265198,6 +79842,7 @@ The modern definition of neurosecretion has evolved to include the release of an DHBA divides this into A(1-3),B(4),C(5-7) and D(8) hindbrain segment segment of hindbrain + DHBA:12664 EFO:0003617 EMAPA:16148 @@ -265207,7 +79852,6 @@ The modern definition of neurosecretion has evolved to include the release of an RETIRED_EHDAA2:0000669 TAO:0001064 VHOG:0000672 - Wikipedia:Rhombomere XAO:0004079 ZFA:0001064 hindbrain neuromere @@ -265227,27 +79871,27 @@ The modern definition of neurosecretion has evolved to include the release of an A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP]. - Wikipedia:Rhombomere - ZFIN:curator + + ZFIN:curator A segment of the developing hindbrain. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001064 - TAO - ZFIN:curator + TAO + ZFIN:curator Rhombomeric segmentation is found in all living vertebrates and is of fundamental importance to the development of the vertebrate head.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000672 - VHOG + VHOG + DOI:10.1006/dbio.2002.0831 Mazet F, Shimeld SM, The Evolution of Chordate Neural Segmentation. Developmental Biology (2002) - http://bgee.unil.ch/ @@ -265266,7 +79910,7 @@ The modern definition of neurosecretion has evolved to include the release of an hindbrain neuromeres DHBA:HNM - + @@ -265279,7 +79923,7 @@ The modern definition of neurosecretion has evolved to include the release of an rhombomeres VHOG:0000672 - + @@ -265319,6 +79963,9 @@ The modern definition of neurosecretion has evolved to include the release of an The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG] epencephalon + + + BAMS:Met BIRNLEX:965 BTO:0000673 @@ -265336,7 +79983,6 @@ The modern definition of neurosecretion has evolved to include the release of an UMLS:C0376353 UMLS:C1516904 VHOG:0000741 - Wikipedia:Metencephalon neuronames:543 epencephalon-2 uberon @@ -265345,7 +79991,7 @@ The modern definition of neurosecretion has evolved to include the release of an the terms metencephalon and myelencephalon are only meaningful in mammals and birds[Neuroanatomy of the Zebrafish Brain]. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata and thus these are not distinguished in ZFA[ZFA]. metencephalon - http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg + http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg @@ -265356,14 +80002,14 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]. - Wikipedia:Metencephalon - https://github.com/obophenotype/uberon/issues/300 + + @@ -265375,21 +80021,21 @@ The modern definition of neurosecretion has evolved to include the release of an The anterior of two brain vesicles formed by specialization of the rhombencephalon in the developing embryo. It gives rise to cerebellum and pons. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000741 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/metencephalon + VHOG + + The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000741 - VHOG + VHOG + ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500 - http://bgee.unil.ch/ @@ -265430,6 +80076,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -265473,6 +80120,10 @@ The modern definition of neurosecretion has evolved to include the release of an Classical anatomical studies subdivided the vertebrate rhombencephalon into pons and medulla oblongata. (...) The medulla oblongata appears therefore as a tagma, that is, a group of segmental units (pseudorhombomeres, in this case) sharing some morphological and molecular characteristics, and in some aspects different from the segmental units present in adjoining brain regions, pons and spinal cord.[well established][VHOG] bulb medulla + + + + AAO:0010486 BAMS:MY BAMS:Md @@ -265495,12 +80146,12 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D008526 MIAA:0000111 NCIT:C12442 - SCTID:279104005 + OpenCyc:Mx4rvVjxSJwpEbGdrcN5Y29ycA + OpenCyc:Mx4rwCqnXJwpEbGdrcN5Y29ycA TAO:0000545 UMLS:C0025148 UMLS:C1269575 VHOG:0000181 - Wikipedia:Bone_marrow_of_ovary_oblongata XAO:0003100 ZFA:0000545 neuronames:698 @@ -265515,43 +80166,43 @@ The modern definition of neurosecretion has evolved to include the release of an medulla oblongata - http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg + http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]. + FMA:62004 GO:0021550 - Wikipedia:Bone_marrow_of_ovary_oblongata Posterior portion of the hindbrain which controls respiration, heartbeat, digestion, and swallowing as well as some locomotor responses.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010486 - AAO - AAO:BJB + AAO + AAO:BJB The posterior region of the brain that is continuous with the spinal cord. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-17, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000181 - VHOG - http://bgee.unil.ch/ + VHOG + Classical anatomical studies subdivided the vertebrate rhombencephalon into pons and medulla oblongata. (...) The medulla oblongata appears therefore as a tagma, that is, a group of segmental units (pseudorhombomeres, in this case) sharing some morphological and molecular characteristics, and in some aspects different from the segmental units present in adjoining brain regions, pons and spinal cord.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000181 - VHOG + VHOG + DOI:10.1016/j.ydbio.2008.08.017 Marin F, Aroca P, Puelles L, Hox gene colinear expression in the avian medulla oblongata is correlated with pseudorhombomeric domains. Developmental Biology (2008) - http://bgee.unil.ch/ @@ -265564,6 +80215,11 @@ The modern definition of neurosecretion has evolved to include the release of an UMLS:C0025148 BIRNLEX:957 + + + + + UMLS:C0025148 ncithesaurus:Medulla_Oblongata @@ -265583,14 +80239,14 @@ The modern definition of neurosecretion has evolved to include the release of an bulbus FMA:62004 - FMA:TA + FMA:TA medulla oblonzata - Wikipedia:Medulla_oblongata + @@ -265602,6 +80258,121 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The epithelial lining of the trachea which contains numerous ciliated cells. + + UBERON:0003227 + + BTO:0001389 + CALOHA:TS-1061 + EHDAA2:0002069 + EHDAA:5007 + EMAPA:16855 + EMAPA:18409 + FMA:62015 + MA:0001862 + NCIT:C33797 + UMLS:C1179002 + VHOG:0001045 + epithelial tissue of trachea + epithelial tissue of windpipe + epithelium of windpipe + trachea epithelial tissue + trachea epithelium + tracheal epithelium + windpipe epithelial tissue + windpipe epithelium + uberon + UBERON:0001901 + + + epithelium of trachea + + + + + The epithelial lining of the trachea which contains numerous ciliated cells. + ISBN:0-397-51047-0 + MGI:cwg + MP:0002285 + + + + + UMLS:C1179002 + ncithesaurus:Tracheal_Epithelium + + + + + epithelial tissue of trachea + OBOL:automatic + + + + + epithelial tissue of windpipe + OBOL:automatic + + + + + epithelium of windpipe + OBOL:automatic + + + + + trachea epithelial tissue + OBOL:automatic + + + + + windpipe epithelial tissue + OBOL:automatic + + + + + windpipe epithelium + OBOL:automatic + + + + @@ -265637,12 +80408,12 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a small intestine [Automatically generated definition]. Intestinal epithelium which lines the lumen of the mid intestine.[TAO] + BTO:0001258 CALOHA:TS-2104 EMAPA:35778 FMA:62017 MA:0001553 - SCTID:45480009 TAO:0005127 ZFA:0005127 epithelial tissue of small bowel @@ -265668,40 +80439,40 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA An epithelium that is part of a small intestine [Automatically generated definition]. - OBOL:automatic + OBOL:automatic Intestinal epithelium which lines the lumen of the mid intestine.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005127 - TAO - ZFIN:curator + TAO + ZFIN:curator epithelial tissue of small bowel - OBOL:automatic + OBOL:automatic epithelial tissue of small intestine - OBOL:automatic + OBOL:automatic epithelium of small bowel - OBOL:automatic + OBOL:automatic @@ -265713,19 +80484,19 @@ The modern definition of neurosecretion has evolved to include the release of an small bowel epithelial tissue - OBOL:automatic + OBOL:automatic small bowel epithelium - OBOL:automatic + OBOL:automatic small intestine epithelial tissue - OBOL:automatic + OBOL:automatic @@ -265752,6 +80523,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of a capillary [Automatically generated definition]. + BTO:0004954 CALOHA:TS-0112 EMAPA:36292 @@ -265772,7 +80544,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of a capillary [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -265784,25 +80556,25 @@ The modern definition of neurosecretion has evolved to include the release of an blood capillary endothelium - OBOL:automatic + OBOL:automatic capillary vessel endothelium - OBOL:automatic + OBOL:automatic endothelium of blood capillary - OBOL:automatic + OBOL:automatic endothelium of capillary vessel - OBOL:automatic + OBOL:automatic @@ -265830,6 +80602,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of an arteriole [Automatically generated definition]. + EMAPA:36286 FMA:62115 MA:0000705 @@ -265844,7 +80617,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of an arteriole [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -265881,6 +80654,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of an artery [Automatically generated definition]. The endothelium is the thin layer of cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall.[AAO] Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG] + AAO:0011013 BTO:0004757 EMAPA:35148 @@ -265900,26 +80674,26 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of an artery [Automatically generated definition]. - OBOL:automatic + OBOL:automatic The endothelium is the thin layer of cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall.[AAO] - 2012-06-20 + 2012-06-20 AAO:0011013 - AAO + AAO XAO:curator Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001215 - VHOG + VHOG + ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.207 - http://bgee.unil.ch/ @@ -265953,6 +80727,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of a venule [Automatically generated definition]. + EMAPA:36290 FMA:62117 MA:0000716 @@ -265967,7 +80742,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of a venule [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -266002,6 +80777,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of a vein [Automatically generated definition]. Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG] + AAO:0011110 BTO:0004756 EMAPA:36288 @@ -266022,17 +80798,17 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of a vein [Automatically generated definition]. - OBOL:automatic + OBOL:automatic Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001216 - VHOG + VHOG + ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.207 - http://bgee.unil.ch/ @@ -266076,6 +80852,9 @@ The modern definition of neurosecretion has evolved to include the release of an Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG] MTg tegmentum + + + BAMS:MTg BIRNLEX:1200 BTO:0003388 @@ -266087,11 +80866,9 @@ The modern definition of neurosecretion has evolved to include the release of an HBA:9002 MA:0000212 MAT:0000452 - SCTID:362392007 TAO:0000160 UMLS:C0039441 VHOG:0001367 - Wikipedia:Midbrain_tegmentum XAO:0004271 ZFA:0000160 neuronames:491 @@ -266108,7 +80885,7 @@ The modern definition of neurosecretion has evolved to include the release of an 'tegmentum' is used generically for the ventral part of the brainstem (ISBN:0471888893). We use the label 'midbrain tegmentum' to denote the midbrain structure. In NIFSTD tegmentum is a composite structure and there is a separate class for midbrain tegmentum and pontine tegmentum midbrain tegmentum - http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png + http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png @@ -266119,39 +80896,39 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]. - FMA:FMA - ISBN:0471888893 - Wikipedia:Midbrain_tegmentum + + FMA:FMA + ISBN:0471888893 Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001367 - VHOG + VHOG + DOI:10.1016/j.brainresbull.2005.05.001 Villar-Cheda B, Abalo XM, Anadon R, Rodicio MC, The tegmental proliferation region in the sea lamprey. Brain Research Bulletin (2005) - http://bgee.unil.ch/ MTg BIRNLEX:1200 - NIFSTD:NeuroNames_abbrevSource - + NIFSTD:NeuroNames_abbrevSource + tegmentum - ISBN:0471888893 + ISBN:0471888893 @@ -266169,7 +80946,7 @@ The modern definition of neurosecretion has evolved to include the release of an tegmentum mesencephali - Wikipedia:Midbrain_tegmentum + @@ -266211,9 +80988,10 @@ The modern definition of neurosecretion has evolved to include the release of an A multi-tissue structure that is part of a spinal cord. + + BIRNLEX:1496 NCIT:C33969 - SCTID:244437008 UMLS:C1268166 uberon spinal cord part @@ -266225,7 +81003,7 @@ The modern definition of neurosecretion has evolved to include the release of an A multi-tissue structure that is part of a spinal cord. - OBOL:automatic + OBOL:automatic @@ -266236,6 +81014,341 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP]. + + + EMAPA:35192 + FMA:62649 + MA:0001835 + NCIT:C49209 + UMLS:C0225604 + bronchi cartilage + bronchial cartilage + bronchial cartilage ring + bronchial trunk cartilage + bronchus cartilage + cartilage of bronchi + cartilage of bronchial trunk + cartilagines bronchiales + uberon + UBERON:0001956 + + cartilage of bronchus + + + + + + + + + + + MP + + + + + The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP]. + MP:0010988 + + + + + UMLS:C0225604 + ncithesaurus:Bronchus_Cartilage + + + + + bronchi cartilage + OBOL:automatic + + + + + bronchial cartilage ring + MP:0010988 + + + + + bronchial trunk cartilage + OBOL:automatic + + + + + cartilage of bronchi + OBOL:automatic + + + + + cartilage of bronchial trunk + OBOL:automatic + + + + + cartilagines bronchiales + + + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a bronchus [Automatically generated definition]. + + + BTO:0002108 + EMAPA:37449 + FMA:62653 + MA:0001837 + NCIT:C49214 + UMLS:C0225601 + bronchi submucosa + bronchial submucosa + bronchial trunk submucosa + bronchus submucosa + submucosa of bronchi + submucosa of bronchial trunk + tela submucosa bronchi + uberon + submucous layer of bronchi + UBERON:0001957 + submucosa of bronchus + + + + + A submucosa that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37449 + MA:th + + + + + UMLS:C0225601 + ncithesaurus:Bronchus_Submucosa + + + + + bronchi submucosa + OBOL:automatic + + + + + bronchial trunk submucosa + OBOL:automatic + + + + + submucosa of bronchi + OBOL:automatic + + + + + submucosa of bronchial trunk + OBOL:automatic + + + + + tela submucosa bronchi + FMA:62653 + FMA:TA + + + + + + submucous layer of bronchi + BTO:0002108 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that lines a terminal bronchiole. + + A pseudostratified epithelium, containing basal cells, stem cells of the airway, submucosal glands and cartilage rings, is limited to the trachea and large lobar airways in the mouse (Morrisey and Hogan, 2010). This more complex epithelium extends to terminal bronchioles in the human[DOI:10.1242/dev.115469] + + EMAPA:36283 + FMA:62794 + MA:0001774 + NCIT:C33755 + UMLS:C1179400 + bronchiolus terminalis epithelial tissue + bronchiolus terminalis epithelium + epithelial tissue of bronchiolus terminalis + epithelial tissue of terminal bronchiole + epithelium of bronchiolus terminalis + epithelium of terminal bronchiole + terminal bronchiole epithelial tissue + terminal bronchiole epithelium + uberon + UBERON:0001958 + + terminal bronchiole epithelium + + + + + + + + + + + FMA + + + + + An epithelium that lines a terminal bronchiole. + + + + + + UMLS:C1179400 + ncithesaurus:Terminal_Bronchiole_Epithelium + + + + + bronchiolus terminalis epithelial tissue + OBOL:automatic + + + + + bronchiolus terminalis epithelium + OBOL:automatic + + + + + epithelial tissue of bronchiolus terminalis + OBOL:automatic + + + + + epithelial tissue of terminal bronchiole + OBOL:automatic + + + + + epithelium of bronchiolus terminalis + OBOL:automatic + + + + + epithelium of terminal bronchiole + FMA:62794 + + + + + terminal bronchiole epithelial tissue + OBOL:automatic + + + + @@ -266262,8 +81375,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -266291,6 +81404,8 @@ The modern definition of neurosecretion has evolved to include the release of an The liquid component of blood, in which erythrocytes are suspended. plasma portion of plasma + + BTO:0000131 CALOHA:TS-0800 EFO:0001905 @@ -266302,8 +81417,8 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D010949 MIAA:0000052 NCIT:C13356 + OpenCyc:Mx4rEg4ZYrIbEduAAAAOpmP6tw UMLS:C0032105 - Wikipedia:Blood_plasma blood plasm portion of blood plasma uberon @@ -266317,7 +81432,7 @@ The modern definition of neurosecretion has evolved to include the release of an The liquid component of blood, in which erythrocytes are suspended. - http://orcid.org/0000-0002-6601-2165 + @@ -266400,6 +81515,8 @@ The modern definition of neurosecretion has evolved to include the release of an major excretory route for potentially harmful exogenous lipophilic substances many hormones and pheromones are excreted in bile, and contribute to growth and development of the intestine in some species and provide attractants for the weaning of non-human vertebrates protects the organism from enteric infections by excreting immune globulin A (IgA), inflammatory cytokines, and stimulating the innate immune system in the intestine + + BTO:0000121 CALOHA:TS-1172 ENVO:02000023 @@ -266409,7 +81526,6 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D001646 NCIT:C13192 UMLS:C0005388 - Wikipedia:Bile ZFA:0005857 galen:Bile uberon @@ -266435,8 +81551,8 @@ The modern definition of neurosecretion has evolved to include the release of an Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium. - DOI:10.1002/cphy.c120027 - Wikipedia:Bile + + @@ -266480,7 +81596,8 @@ The modern definition of neurosecretion has evolved to include the release of an - . + + BTO:0000501 FMA:62972 GAID:1160 @@ -266488,7 +81605,6 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D005750 NCIT:C32661 UMLS:C0017133 - Wikipedia:Gastric_juice galen:GastricJuice stomach secretion uberon @@ -266498,12 +81614,6 @@ The modern definition of neurosecretion has evolved to include the release of an gastric juice - - - - . - Wikipedia:Gastric_juice - @@ -266547,11 +81657,11 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a esophagus [Automatically generated definition]. + BTO:0002109 EMAPA:35325 FMA:62997 MA:0002724 - SCTID:362128009 esophageal submucosa esophagus submucosa gullet submucosa @@ -266573,38 +81683,38 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a esophagus [Automatically generated definition]. - OBOL:automatic + OBOL:automatic gullet submucosa - OBOL:automatic + OBOL:automatic oesophagus submucosa - OBOL:automatic + OBOL:automatic submucosa of gullet - OBOL:automatic + OBOL:automatic submucosa of oesophagus - OBOL:automatic + OBOL:automatic tela submucosa (oesophagus) FMA:62997 - FMA:TA + FMA:TA @@ -266619,7 +81729,7 @@ The modern definition of neurosecretion has evolved to include the release of an tela submucosa oesophageae FMA:62997 - FMA:TA + FMA:TA @@ -266652,6 +81762,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -266665,6 +81776,7 @@ The modern definition of neurosecretion has evolved to include the release of an A lamina propria that is part of a esophagus [Automatically generated definition]. + EMAPA:26987 FMA:63050 MA:0001568 @@ -266701,13 +81813,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A lamina propria that is part of a esophagus [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -266719,85 +81831,85 @@ The modern definition of neurosecretion has evolved to include the release of an esophagus lamina propria mucosa - OBOL:automatic + OBOL:automatic esophagus lamina propria mucosae - OBOL:automatic + OBOL:automatic gullet lamina propria - OBOL:automatic + OBOL:automatic gullet lamina propria mucosa - OBOL:automatic + OBOL:automatic gullet lamina propria mucosae - OBOL:automatic + OBOL:automatic lamina propria mucosa of esophagus - OBOL:automatic + OBOL:automatic lamina propria mucosa of gullet - OBOL:automatic + OBOL:automatic lamina propria mucosa of oesophagus - OBOL:automatic + OBOL:automatic lamina propria mucosae of gullet - OBOL:automatic + OBOL:automatic lamina propria mucosae of oesophagus - OBOL:automatic + OBOL:automatic lamina propria of gullet - OBOL:automatic + OBOL:automatic lamina propria of oesophagus - OBOL:automatic + OBOL:automatic oesophagus lamina propria mucosa - OBOL:automatic + OBOL:automatic oesophagus lamina propria mucosae - OBOL:automatic + OBOL:automatic @@ -266861,62 +81973,62 @@ The modern definition of neurosecretion has evolved to include the release of an A serous membrane that is part of a esophagus [Automatically generated definition]. - OBOL:automatic + OBOL:automatic esophagus serous membrane - OBOL:automatic + OBOL:automatic gullet serosa - OBOL:automatic + OBOL:automatic gullet serous membrane - OBOL:automatic + OBOL:automatic oesophagus serous membrane - OBOL:automatic + OBOL:automatic serosa of gullet - OBOL:automatic + OBOL:automatic serous membrane of esophagus - OBOL:automatic + OBOL:automatic serous membrane of gullet - OBOL:automatic + OBOL:automatic serous membrane of oesophagus - OBOL:automatic + OBOL:automatic tunica serosa oesophageae FMA:63057 - FMA:TA + FMA:TA @@ -266959,6 +82071,7 @@ The modern definition of neurosecretion has evolved to include the release of an The epithelial layer that lines the luminal space of the esophagus. TODO check epithelium types: in FMA: Nonkeratinizing stratified squamous epithelium; mouse has basal and squamous subtypes; in ZFA it is columnar Simple columnar epithelium that lines the esophagus. Chen et al, 2007.[TAO] + BTO:0001578 CALOHA:TS-0698 EFO:0003041 @@ -266999,23 +82112,23 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The epithelial layer that lines the luminal space of the esophagus. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0000468 Simple columnar epithelium that lines the esophagus. Chen et al, 2007.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001499 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -267027,55 +82140,55 @@ The modern definition of neurosecretion has evolved to include the release of an epithelial tissue of esophagus - OBOL:automatic + OBOL:automatic epithelial tissue of gullet - OBOL:automatic + OBOL:automatic epithelial tissue of oesophagus - OBOL:automatic + OBOL:automatic epithelium of gullet - OBOL:automatic + OBOL:automatic epithelium of oesophagus - OBOL:automatic + OBOL:automatic esophagus epithelial tissue - OBOL:automatic + OBOL:automatic gullet epithelial tissue - OBOL:automatic + OBOL:automatic gullet epithelium - OBOL:automatic + OBOL:automatic oesophagus epithelial tissue - OBOL:automatic + OBOL:automatic @@ -267102,10 +82215,10 @@ The modern definition of neurosecretion has evolved to include the release of an + EMAPA:32925 FMA:63120 MA:0000724 - SCTID:371401008 VHOG:0001430 pancreas parenchyma pancreatic parenchyma @@ -267143,17 +82256,18 @@ The modern definition of neurosecretion has evolved to include the release of an One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins. Multi-tissue structure part of the blood vasculature formed by the anastomosis of capillaries. Venules carry blood toward the heart.[TAO] + + + BTO:0002626 EMAPA:35917 FMA:63130 MA:0000071 MESH:D014699 NCIT:C12818 - SCTID:341687009 TAO:0005315 UMLS:C0042520 VHOG:0001765 - Wikipedia:Venule ZFA:0005315 uberon venula @@ -267163,7 +82277,7 @@ The modern definition of neurosecretion has evolved to include the release of an venule - https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg + https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg @@ -267176,10 +82290,10 @@ The modern definition of neurosecretion has evolved to include the release of an Multi-tissue structure part of the blood vasculature formed by the anastomosis of capillaries. Venules carry blood toward the heart.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005315 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -267191,7 +82305,7 @@ The modern definition of neurosecretion has evolved to include the release of an venula - Wikipedia:Venule + @@ -267238,6 +82352,9 @@ The modern definition of neurosecretion has evolved to include the release of an The smallest division of the artery located between the muscular arteries and the capillaries[GO]. Multi-tissue structure part of the blood vasculature, feeds into capillaries. Arterioles carry blood away from the heart.[TAO] Small, terminal branch of an artery which generally connects to capillaries.[AAO] + + + AAO:0010253 BTO:0001997 EMAPA:35146 @@ -267245,11 +82362,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000063 MESH:D001160 NCIT:C12672 - SCTID:337724002 TAO:0002138 UMLS:C0003847 VHOG:0001763 - Wikipedia:Arteriole ZFA:0005255 uberon arteriola @@ -267258,13 +82373,13 @@ The modern definition of neurosecretion has evolved to include the release of an arteriole - https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg + https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg - MA + MA @@ -267276,19 +82391,19 @@ The modern definition of neurosecretion has evolved to include the release of an Multi-tissue structure part of the blood vasculature, feeds into capillaries. Arterioles carry blood away from the heart.[TAO] - 2012-08-14 + 2012-08-14 TAO:0002138 - TAO - ZFIN:curator + TAO + ZFIN:curator Small, terminal branch of an artery which generally connects to capillaries.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010253 - AAO - AAO:BJB + AAO + AAO:BJB @@ -267300,7 +82415,7 @@ The modern definition of neurosecretion has evolved to include the release of an arteriola - Wikipedia:Arteriole + @@ -267309,7 +82424,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -267362,13 +82476,15 @@ The modern definition of neurosecretion has evolved to include the release of an A vessel through which blood circulates in the body. consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus - Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG] Any of the vessels through which blood circulates in the body.[AAO] The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] annelids have blood vessels, but this class is not applicable to annelids. FMA:63183 Blood vessel is categorized as 'general anatomical term'. Suggestion to map to region of vascular tree from Terry H at JAX vascular element + + + AAO:0011004 AEO:0000207 BTO:0001102 @@ -267386,11 +82502,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D001808 NCIT:C12679 NLXANAT:090901 - SCTID:361097006 + OpenCyc:Mx4rvVjxlpwpEbGdrcN5Y29ycA TAO:0002137 UMLS:C0005847 VHOG:0001250 - Wikipedia:Blood_vessel XAO:0001011 ZFA:0005314 region of vascular tree organ @@ -267399,12 +82514,11 @@ The modern definition of neurosecretion has evolved to include the release of an vas sanguineum UBERON:0001981 - blood vessel - http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg + http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg @@ -267415,7 +82529,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -267426,7 +82540,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -267443,42 +82557,42 @@ The modern definition of neurosecretion has evolved to include the release of an A vessel through which blood circulates in the body. + BTO:0001102 - Wikipedia:Blood_vessel Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001250 - VHOG - http://bgee.unil.ch/ + VHOG + Any of the vessels through which blood circulates in the body.[AAO] - 2012-06-20 + 2012-06-20 AAO:0011004 - AAO - AAO:EJS + AAO + AAO:EJS The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001250 - VHOG + VHOG + DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006) - http://bgee.unil.ch/ FMA:63183 Blood vessel is categorized as 'general anatomical term'. Suggestion to map to region of vascular tree from Terry H at JAX - FMA + FMA @@ -267508,7 +82622,7 @@ The modern definition of neurosecretion has evolved to include the release of an vas sanguineum - Wikipedia:Blood_vessel + @@ -267551,6 +82665,8 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the tiny blood vessels connecting the arterioles to the venules.[AAO] The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] capillaries lack tunica media and tunica adventitia; only the endothelial wall of the tunica intima belongs + + AAO:0010252 BTO:0002045 CALOHA:TS-2006 @@ -267562,10 +82678,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D002196 NCIT:C12685 NLXANAT:090902 + OpenCyc:Mx4rvWEU-5wpEbGdrcN5Y29ycA TAO:0005250 UMLS:C0935624 VHOG:0001253 - Wikipedia:Capillary XAO:0000116 ZFA:0005250 blood capillary @@ -267579,34 +82695,34 @@ The modern definition of neurosecretion has evolved to include the release of an capillary https://github.com/obophenotype/uberon/issues/2186 - http://upload.wikimedia.org/wikipedia/commons/2/2f/A_red_blood_cell_in_a_capillary,_pancreatic_tissue_-_TEM.jpg + http://upload.wikimedia.org/wikipedia/commons/2/2f/A_red_blood_cell_in_a_capillary,_pancreatic_tissue_-_TEM.jpg Any of the smallest blood vessels connecting arterioles with venules. - ISBN:0073040584 - Wikipedia:Capillary - https://github.com/obophenotype/uberon/issues/137 + + + ISBN:0073040584 Any of the tiny blood vessels connecting the arterioles to the venules.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010252 - AAO - AAO:BJB + AAO + AAO:BJB The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001253 - VHOG + VHOG + DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006) - http://bgee.unil.ch/ @@ -267660,6 +82776,9 @@ The modern definition of neurosecretion has evolved to include the release of an A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]. + + + CALOHA:TS-0172 EMAPA:35935 FMA:63882 @@ -267667,10 +82786,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001242 MESH:D004728 NCIT:C12707 - SCTID:368827009 TAO:0002186 UMLS:C0014259 - Wikipedia:Corneal_endothelium ZFA:0001687 cornea endothelium endothelium of cornea @@ -267682,7 +82799,7 @@ The modern definition of neurosecretion has evolved to include the release of an corneal endothelium - http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png + http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png @@ -267693,13 +82810,13 @@ The modern definition of neurosecretion has evolved to include the release of an - WP + WP A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]. - Wikipedia:Corneal_endothelium + @@ -267711,19 +82828,19 @@ The modern definition of neurosecretion has evolved to include the release of an cornea endothelium - OBOL:automatic + OBOL:automatic endothelium of cornea - OBOL:automatic + OBOL:automatic epithelium posterius corneae - Wikipedia:Corneal_endothelium + @@ -267766,6 +82883,8 @@ The modern definition of neurosecretion has evolved to include the release of an A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA]. endothelial + + BTO:0000393 CALOHA:TS-0278 EFO:0002548 @@ -267773,7 +82892,6 @@ The modern definition of neurosecretion has evolved to include the release of an GAID:520 MESH:D004727 NCIT:C12481 - SCTID:27168002 UMLS:C0014257 galen:Endothelium uberon @@ -267788,8 +82906,8 @@ The modern definition of neurosecretion has evolved to include the release of an + FMA-text-def - https://github.com/obophenotype/uberon/issues/225 @@ -267807,9 +82925,9 @@ The modern definition of neurosecretion has evolved to include the release of an A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA]. + FMA:63916 MESH:A10.272.491 - https://github.com/obophenotype/uberon/issues/225 @@ -267845,6 +82963,8 @@ The modern definition of neurosecretion has evolved to include the release of an Excretion in semisolid state processed by the intestine.[FMA] fecal excreta + + BTO:0000440 CALOHA:TS-2345 ENVO:00002003 @@ -267855,8 +82975,8 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D005243 MIAA:0000053 NCIT:C13234 + OpenCyc:Mx4rvVjJMZwpEbGdrcN5Y29ycA UMLS:C0015733 - Wikipedia:Feces galen:Feces faeces fecal material @@ -267894,8 +83014,8 @@ The modern definition of neurosecretion has evolved to include the release of an Portion of semisolid bodily waste discharged through the anus[MW,modified]. - Wikipedia:Feces - http://www.merriam-webster.com/dictionary/feces + + @@ -267913,7 +83033,7 @@ The modern definition of neurosecretion has evolved to include the release of an piece of shit - PMID:23285307 + @@ -267925,37 +83045,37 @@ The modern definition of neurosecretion has evolved to include the release of an cow dung - Wikipedia:Cow_dung + cow pat - Wikipedia:Cow_dung + fewmet - Wikipedia:Fewmet + frass - Wikipedia:Frass + guano - Wikipedia:Guano + spraint - Wikipedia:Spraint + @@ -267966,6 +83086,107 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance. + Cartilage (tissue) which consists of chondrocytes and collagen, the intercellular matrix of which is an amorphous gel with a perichondrium[FMA:64783]. + Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance.[VSAO] + + + + EMAPA:35414 + FMA:64783 + MA:0000109 + NCIT:C32746 + UMLS:C0225362 + VSAO:0000094 + XAO:0004029 + hyaline cartilage + uberon + chondroid cartilage + UBERON:0001994 + + + hyaline cartilage tissue + http://upload.wikimedia.org/wikipedia/commons/2/2a/Gray292.png + http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg + + + + + + FMA + + + + + + + + + + + VSAO-text-def + + + + + Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance. + + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000094 + + + + + Cartilage (tissue) which consists of chondrocytes and collagen, the intercellular matrix of which is an amorphous gel with a perichondrium[FMA:64783]. + FMA:64783 + + + + + Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance.[VSAO] + 2012-08-14 + VSAO:0000094 + VSAO + PSPUB:0000170 + + + + + UMLS:C0225362 + ncithesaurus:Hyaline_Cartilage + + + + + hyaline cartilage + MA:0000109 + + + + + chondroid cartilage + + + + + @@ -267985,6 +83206,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -268035,6 +83257,9 @@ The modern definition of neurosecretion has evolved to include the release of an One of two arteries, leaving from the heart, the left one supplying the left lung and the right one supplying the right lung. [TFD][VHOG] On the other hand, in the sister clade of the actinopterygians, the sarcopterygians, the gill circulation is supplemented with lung ventilation. As a result, the pulmonary artery and vein and a functional ductus arteriosus arose as a major evolutionary innovation from the sixth arch, giving the organism a flexible shunt to balance blood supply to and from gills and lungs according to environmental conditions.[well established][VHOG] In the human heart, the pulmonary trunk (pulmonary artery or main pulmonary artery) begins at the base of the right ventricle. It is short and wide - approximately 5 cm (2 inches) in length and 3 cm (1.2 inches) in diameter. It then branches into two pulmonary arteries (left and right), which deliver deoxygenated blood to the corresponding lung[WP] + + + AAO:0010221 BTO:0000778 CALOHA:TS-0839 @@ -268047,10 +83272,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002031 MESH:D011651 NCIT:C12774 - SCTID:181380003 + OpenCyc:Mx4rvVjbIpwpEbGdrcN5Y29ycA UMLS:C0034052 VHOG:0000982 - Wikipedia:Pulmonary_artery XAO:0004162 galen:PulmonaryArtery pulmonary arterial tree @@ -268065,9 +83289,7 @@ The modern definition of neurosecretion has evolved to include the release of an pulmonary artery - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb - https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png + https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png @@ -268078,7 +83300,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia @@ -268089,8 +83311,8 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 - XAO + EHDAA2 + XAO @@ -268101,43 +83323,43 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood.. - Wikipedia:Pulmonary_artery - http://orcid.org/0000-0002-6601-2165 + + Major artery which supplies blood to the lungs.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010221 - AAO - AAO:BJB + AAO + AAO:BJB One of two arteries, leaving from the heart, the left one supplying the left lung and the right one supplying the right lung. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000982 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/pulmonary+artery + VHOG + + On the other hand, in the sister clade of the actinopterygians, the sarcopterygians, the gill circulation is supplemented with lung ventilation. As a result, the pulmonary artery and vein and a functional ductus arteriosus arose as a major evolutionary innovation from the sixth arch, giving the organism a flexible shunt to balance blood supply to and from gills and lungs according to environmental conditions.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000982 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 - http://bgee.unil.ch/ @@ -268161,7 +83383,7 @@ The modern definition of neurosecretion has evolved to include the release of an arteria pulmonalis - Wikipedia:Pulmonary_artery + @@ -268174,7 +83396,7 @@ The modern definition of neurosecretion has evolved to include the release of an truncus pulmonalis - Wikipedia:Pulmonary_artery + @@ -268195,6 +83417,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -268233,6 +83456,9 @@ The modern definition of neurosecretion has evolved to include the release of an the veins that return oxygenated blood from the lungs to the left atrium of the heart On the other hand, in the sister clade of the actinopterygians, the sarcopterygians, the gill circulation is supplemented with lung ventilation. As a result, the pulmonary artery and vein and a functional ductus arteriosus arose as a major evolutionary innovation from the sixth arch, giving the organism a flexible shunt to balance blood supply to and from gills and lungs according to environmental conditions.[well established][VHOG] + + + AAO:0010521 BTO:0001799 CALOHA:TS-0840 @@ -268244,10 +83470,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002206 MESH:D011667 NCIT:C12776 - SCTID:430160002 UMLS:C0034090 VHOG:0001133 - Wikipedia:Pulmonary_vein XAO:0000394 galen:PulmonaryVein pulmonary venous tree organ part @@ -268258,9 +83482,7 @@ The modern definition of neurosecretion has evolved to include the release of an pulmonary vein - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb - https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png + https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png @@ -268272,20 +83494,20 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the veins which collect blood from the lungs and some small vesicles received from the esophagus.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010521 - AAO - AAO:BJB + AAO + AAO:BJB One of two pairs of large vessels that return oxygenated blood from each lung to the left atrium of the heart. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001133 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/pulmonary+vein + VHOG + + @@ -268297,11 +83519,11 @@ The modern definition of neurosecretion has evolved to include the release of an On the other hand, in the sister clade of the actinopterygians, the sarcopterygians, the gill circulation is supplemented with lung ventilation. As a result, the pulmonary artery and vein and a functional ductus arteriosus arose as a major evolutionary innovation from the sixth arch, giving the organism a flexible shunt to balance blood supply to and from gills and lungs according to environmental conditions.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001133 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 - http://bgee.unil.ch/ @@ -268313,7 +83535,7 @@ The modern definition of neurosecretion has evolved to include the release of an venae pulmonales - Wikipedia:Pulmonary_vein + @@ -268331,6 +83553,8 @@ The modern definition of neurosecretion has evolved to include the release of an A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO]. + + BTO:0001792 CALOHA:TS-0814 EHDAA2:0001485 @@ -268341,7 +83565,7 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002198 MESH:D011169 NCIT:C33343 - SCTID:362064007 + OpenCyc:Mx4rv_bem5wpEbGdrcN5Y29ycA UMLS:C0032718 VHOG:0000656 XAO:0000392 @@ -268353,13 +83577,13 @@ The modern definition of neurosecretion has evolved to include the release of an portal vein - http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png + http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png - FMA + FMA @@ -268400,6 +83624,8 @@ The modern definition of neurosecretion has evolved to include the release of an A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons. Multi-tissue comprised of neurons, dendrites, axon terminals, glial cells, and capillaries.[TAO] + + AEO:0001012 EHDAA2:0003136 EHDAA2_RETIRED:0004658 @@ -268409,10 +83635,10 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001112 MESH:D066128 NCIT:C32695 + OpenCyc:Mx4rwDdKMpwpEbGdrcN5Y29ycA TAO:0002197 UMLS:C0018220 VHOG:0001768 - Wikipedia:Gray_matter ZFA:0001681 neuronames:2869 gray matter @@ -268430,29 +83656,29 @@ The modern definition of neurosecretion has evolved to include the release of an gray matter - https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg + https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons. - Wikipedia:Gray_matter - http://orcid.org/0000-0002-6601-2165 + + Multi-tissue comprised of neurons, dendrites, axon terminals, glial cells, and capillaries.[TAO] - 2012-08-14 + 2012-08-14 TAO:0002197 - TAO - ZFIN:curator + TAO + ZFIN:curator EMAPA:37596 - MA:th + MA:th @@ -268477,7 +83703,7 @@ The modern definition of neurosecretion has evolved to include the release of an substantia grisea FMA:67242 - FMA:TA + FMA:TA @@ -268499,6 +83725,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -268546,6 +83773,10 @@ The modern definition of neurosecretion has evolved to include the release of an Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG] rhombencephalic in MA, brainstem and hindbrain and part-of siblings under brain, consistent with FMA and NIF. See also notes for cerebellum. We weaken the relation in ABA to overlaps + + + + AAO:0010150 BAMS:HB BIRNLEX:942 @@ -268565,12 +83796,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D012249 MIAA:0000107 NCIT:C40336 - SCTID:303456008 TAO:0000029 UMLS:C0035507 UMLS:C1522180 VHOG:0000070 - Wikipedia:Rhombencephalon XAO:0000015 ZFA:0000029 neuronames:540 @@ -268583,7 +83812,7 @@ The modern definition of neurosecretion has evolved to include the release of an hindbrain - http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg + http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg @@ -268594,7 +83823,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -268606,7 +83835,7 @@ The modern definition of neurosecretion has evolved to include the release of an modified-source-relation - ABA + ABA @@ -268617,84 +83846,89 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]. - Wikipedia:Rhombencephalon + ZFA:0000029 - ZFIN:curator + ZFIN:curator - ZFA - ABA - https://github.com/obophenotype/uberon/issues/378 + ZFA + + ABA pending - ABA + ABA - PMID:8932866 + Posterior part of the brain consisting of the cerebellum and medulla oblongata.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010150 - AAO - AAO:BJB + AAO + AAO:BJB The most posterior of the three principal regions of the brain, forming the rhombencephalon and all or most of the metencephalon. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000029 - TAO - ZFIN:curator + TAO + ZFIN:curator relationship loss: develops_from hindbrain neural tube (TAO:0007043)[TAO] - 2012-08-14 + 2012-08-14 TAO:0000029 - TAO + TAO Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000070 - VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) - http://bgee.unil.ch/ + VHOG + + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) in MA, brainstem and hindbrain and part-of siblings under brain, consistent with FMA and NIF. See also notes for cerebellum. We weaken the relation in ABA to overlaps - MA + MA UMLS:C0035507 BIRNLEX:942 + + + + + UMLS:C0035507 ncithesaurus:Hind-Brain @@ -268742,6 +83976,7 @@ The modern definition of neurosecretion has evolved to include the release of an The simple columnar epithelial lining of the gall bladder. + BTO:0001449 CALOHA:TS-1304 EMAPA:35370 @@ -268778,37 +84013,184 @@ The modern definition of neurosecretion has evolved to include the release of an epithelial tissue of gall bladder - OBOL:automatic + OBOL:automatic epithelial tissue of gallbladder - OBOL:automatic + OBOL:automatic epithelium of gallbladder - OBOL:automatic + OBOL:automatic gall bladder epithelial tissue - OBOL:automatic + OBOL:automatic gallbladder epithelial tissue - OBOL:automatic + OBOL:automatic gallbladder epithelium - OBOL:automatic + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a bronchus [Automatically generated definition]. + + BTO:0001845 + CALOHA:TS-1240 + EFO:0000307 + EMAPA:32691 + FMA:67782 + MA:0001839 + NCIT:C32231 + UMLS:C0599333 + bronchi epithelial tissue + bronchi epithelium + bronchial epithelium + bronchial trunk epithelial tissue + bronchial trunk epithelium + bronchus epithelial tissue + bronchus epithelium + epithelial tissue of bronchi + epithelial tissue of bronchial trunk + epithelial tissue of bronchus + epithelium of bronchi + epithelium of bronchial trunk + uberon + UBERON:0002031 + + + epithelium of bronchus + + + + + + + + + + + FMA + + + + + An epithelium that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C0599333 + ncithesaurus:Bronchial_Epithelium + + + + + bronchi epithelial tissue + OBOL:automatic + + + + + bronchi epithelium + OBOL:automatic + + + + + bronchial trunk epithelial tissue + OBOL:automatic + + + + + bronchial trunk epithelium + OBOL:automatic + + + + + bronchus epithelial tissue + OBOL:automatic + + + + + epithelial tissue of bronchi + OBOL:automatic + + + + + epithelial tissue of bronchial trunk + OBOL:automatic + + + + + epithelial tissue of bronchus + OBOL:automatic + + + + + epithelium of bronchi + OBOL:automatic + + + + + epithelium of bronchial trunk + OBOL:automatic @@ -268836,6 +84218,8 @@ The modern definition of neurosecretion has evolved to include the release of an Muscle tissue that contains fibers that are divided by transverse bands into striations. Voluntary muscle tissue arranged in bundles of fibers.[AAO] + + AAO:0010762 AEO:0000140 CALOHA:TS-2047 @@ -268844,9 +84228,9 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:67905 MA:0002438 NCIT:C12436 + OpenCyc:Mx4rwAoze5wpEbGdrcN5Y29ycA UMLS:C1331262 WBbt:0005779 - Wikipedia:Striated_muscle galen:StriatedMuscle striated muscle uberon @@ -268860,16 +84244,16 @@ The modern definition of neurosecretion has evolved to include the release of an Muscle tissue that contains fibers that are divided by transverse bands into striations. CL:0000737 - GOC:dph + GOC:dph GOC:mtg_muscle Voluntary muscle tissue arranged in bundles of fibers.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010762 - AAO + AAO AAO:CAM @@ -268912,18 +84296,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - @@ -268932,15 +84304,17 @@ The modern definition of neurosecretion has evolved to include the release of an A systemic artery that supplies the lung with with oxygenated blood. + + + EMAPA:18608 FMA:68109 GAID:477 MA:0001923 MESH:D001981 NCIT:C32230 - SCTID:244247009 + OpenCyc:Mx4r4sy0UiNbEd2AAAACs6hRXg UMLS:C0006257 - Wikipedia:Bronchial_artery bronchial arterial tree uberon arteriae bronchiales @@ -268950,14 +84324,14 @@ The modern definition of neurosecretion has evolved to include the release of an Although there is much variation, there are usually two bronchial arteries that run to the left lung, and one to the right lung. bronchial artery - http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray1032.png + http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray1032.png A systemic artery that supplies the lung with with oxygenated blood. - UBERON:cjm - Wikipedia:Bronchial_artery + + UBERON:cjm @@ -268969,14 +84343,14 @@ The modern definition of neurosecretion has evolved to include the release of an arteriae bronchiales - Wikipedia:Bronchial_artery + rami bronchiales partis thoracicae aortae - Wikipedia:Bronchial_artery + @@ -269004,6 +84378,8 @@ The modern definition of neurosecretion has evolved to include the release of an + + BAMS:PnR BAMS:RA-PONS BAMS:RPn @@ -269015,7 +84391,6 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001022 MBA:238 UMLS:C0175423 - Wikipedia:Pontine_raphe_nucleus neuronames:589 raphe of pons raphe pontis @@ -269038,37 +84413,37 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted]. - Wikipedia:Pontine_raphe_nucleus + - ABA + ABA - ABA + ABA - ABA + ABA - ABA + ABA @@ -269087,7 +84462,7 @@ The modern definition of neurosecretion has evolved to include the release of an raphe pontis FMA:68875 - FMA:TA + FMA:TA @@ -269101,7 +84476,7 @@ The modern definition of neurosecretion has evolved to include the release of an nucleus raphes pontis - Wikipedia:Pontine_raphe_nucleus + @@ -269197,6 +84572,9 @@ The modern definition of neurosecretion has evolved to include the release of an Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata. (...) In actinopterygian fishes, apart from Cladistia, the ventral intestinal pocket migrates dorsally and becomes the swim-bladder, a mainly hydrostatical organ (reference 1); Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung (reference 2).[well established][VHOG] pulmonary respiration organ in all air-breathing animals, including most tetrapods, a few fish and a few snails. In mammals and the more complex life forms, the two lungs are located in the chest on either side of the heart. Their principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere. This exchange of gases is accomplished in the mosaic of specialized cells that form millions of tiny, exceptionally thin-walled air sacs called alveoli. // Avian lungs do not have alveoli as mammalian lungs do, they have Faveolar lungs. They contain millions of tiny passages known as para-bronchi, connected at both ends by the dorsobronchi + + + AAO:0000275 AAO:0010567 BTO:0000763 @@ -269214,10 +84592,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D008168 MIAA:0000135 NCIT:C12468 - SCTID:181216001 + OpenCyc:Mx4rvVjKy5wpEbGdrcN5Y29ycA UMLS:C0024109 VHOG:0000310 - Wikipedia:Lung XAO:0000119 galen:Lung pulmo @@ -269232,10 +84609,6 @@ The modern definition of neurosecretion has evolved to include the release of an Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP] lung https://github.com/obophenotype/uberon/issues/701 - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-lung.glb @@ -269252,40 +84625,40 @@ The modern definition of neurosecretion has evolved to include the release of an Respiration organ that develops as an outpocketing of the esophagus. - http://orcid.org/0000-0002-6601-2165 + https://orcid.org/0000-0002-9415-5104 - https://github.com/obophenotype/uberon/issues/701 + https://orcid.org/0000-0002-9415-5104 - https://github.com/obophenotype/uberon/issues/701 + Either of two organs which allow gas exchange absorbing oxygen from inhaled air and releasing carbon dioxide with exhaled air.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010567 - AAO + AAO AAO:SBH Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata. (...) In actinopterygian fishes, apart from Cladistia, the ventral intestinal pocket migrates dorsally and becomes the swim-bladder, a mainly hydrostatical organ (reference 1); Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000310 - VHOG + VHOG + ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.210, DOI:10.1371/journal.pone.0024019 Zheng W, Wang Z, Collins JE, Andrews RM, Stemple D, Gong Z, Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung. PLoS One (2011) - http://bgee.unil.ch/ @@ -269305,6 +84678,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -269340,13 +84714,13 @@ The modern definition of neurosecretion has evolved to include the release of an vasculature - http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg + http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg - FMA + FMA @@ -269389,6 +84763,8 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[TAO] Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[VSAO] in FMA embryo is_a embryonic structure + + AAO:0000138 BILA:0000034 BTO:0000174 @@ -269400,7 +84776,6 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D004628 NCIT:C13229 RETIRED_EHDAA2:0003169 - SCTID:667009 TAO:0001105 UMLS:C0013948 VSAO:0000178 @@ -269423,40 +84798,40 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure that is part of an embryo. BTO:0000174 - ZFIN:curator + ZFIN:curator Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000138 - AAO - AAO:BJB + AAO + AAO:BJB Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001105 - TAO - ZFIN:curator + TAO + ZFIN:curator Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000178 - VSAO - ZFIN:curator + VSAO + ZFIN:curator in FMA embryo is_a embryonic structure - FMA + FMA @@ -269487,7 +84862,155 @@ The modern definition of neurosecretion has evolved to include the release of an embryonic structures ZFA:0001105 - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a bronchiole [Automatically generated definition]. + + in FMA2 and FMA3, lobular bronchiole is an exact synonym of bronchiole; however there are two distinct terms for the corresponding epithelium. + + BTO:0001866 + CALOHA:TS-0570 + EMAPA:32693 + FMA:62497 + FMA:69077 + MA:0001772 + NCIT:C48942 + UMLS:C1181296 + bronchiolar epithelium + bronchiole epithelial tissue + bronchiole epithelium + epithelial tissue of bronchiole + epithelial tissue of lobular bronchiole + epithelium of lobular bronchiole + lobular bronchiole epithelial tissue + lobular bronchiole epithelium + uberon + UBERON:0002051 + + + epithelium of bronchiole + + + + + + BTO + + + + + + + + + + + FMA + + + + + An epithelium that is part of a bronchiole [Automatically generated definition]. + OBOL:automatic + + + + + in FMA2 and FMA3, lobular bronchiole is an exact synonym of bronchiole; however there are two distinct terms for the corresponding epithelium. + FMA + + + + + UMLS:C1181296 + ncithesaurus:Bronchiole_Epithelium + + + + + bronchiolar epithelium + BTO:0001866 + + + + + bronchiole epithelial tissue + OBOL:automatic + + + + + epithelial tissue of bronchiole + OBOL:automatic + + + + + epithelial tissue of lobular bronchiole + OBOL:automatic + + + + + epithelium of lobular bronchiole + OBOL:automatic + + + + + lobular bronchiole epithelial tissue + OBOL:automatic + + + + + lobular bronchiole epithelium + OBOL:automatic @@ -269521,6 +85044,7 @@ The modern definition of neurosecretion has evolved to include the release of an An artery that supplies the diaphragm. In humans this includes the superior and inferior phrenic arteries + EMAPA:37108 FMA:69330 MA:0002019 @@ -269535,13 +85059,13 @@ The modern definition of neurosecretion has evolved to include the release of an An artery that supplies the diaphragm. - https://orcid.org/0000-0002-6601-2165 + EMAPA:37108 - MA:th + MA:th @@ -269558,6 +85082,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -269578,6 +85103,9 @@ The modern definition of neurosecretion has evolved to include the release of an The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles. assume spelling error for ncit + + + EHDAA2:0004143 EMAPA:35887 FMA:70301 @@ -269585,9 +85113,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000103 MESH:D014338 NCIT:C34317 - SCTID:308828009 + OpenCyc:Mx4rquH9YKgNEdudWQACs5b6Bw UMLS:C1519589 - Wikipedia:Truncus_arteriosus_(embryology) uberon UBERON:0002061 @@ -269597,13 +85124,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 - FMA + FMA @@ -269614,7 +85141,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -269625,7 +85152,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -269636,13 +85163,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles. - Wikipedia:Truncus_arteriosus_(embryology) + @@ -269695,6 +85222,7 @@ The modern definition of neurosecretion has evolved to include the release of an Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves.[TAO] relationship loss: develops_from endocardial ring (TAO:0005072)[TAO] (Cardiac valve formation in vertebrates) In response to a myocardial signal, endocardial cells at chamber boundaries take on a mesenchymal character, delaminate and migrate into the cardiac jelly. There, they form an endocardial cushion that is later remodelled into a valve.[well established][VHOG] + EHDAA2:0000434 EHDAA2:0004028 EHDAA:2586 @@ -269704,7 +85232,6 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D054089 TAO:0001317 VHOG:0000932 - Wikipedia:Atrioventricular_cushions XAO:0004189 ZFA:0001317 AV cushion @@ -269720,13 +85247,13 @@ The modern definition of neurosecretion has evolved to include the release of an GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form endocardial cushion - http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray465.png + http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray465.png - GO + GO @@ -269737,7 +85264,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -269748,7 +85275,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -269759,55 +85286,55 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia - https://github.com/obophenotype/uberon/wiki/The-neural-crest + + Wikipedia The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]. + GO:0003197 - Wikipedia:Atrioventricular_cushions - ZFIN:curator + ZFIN:curator Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001317 - TAO - ZFIN:curator + TAO + ZFIN:curator relationship loss: develops_from endocardial ring (TAO:0005072)[TAO] - 2012-08-14 + 2012-08-14 TAO:0001317 - TAO + TAO (Cardiac valve formation in vertebrates) In response to a myocardial signal, endocardial cells at chamber boundaries take on a mesenchymal character, delaminate and migrate into the cardiac jelly. There, they form an endocardial cushion that is later remodelled into a valve.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000932 - VHOG + VHOG + DOI:10.1038/35047564 Stainier DYR, Zebrafish genetics and vertebrate heart formation. Nature Reviews Genetics (2001) Figure 3 - http://bgee.unil.ch/ atrioventricular cushion - Wikipedia:Endocardial_cushion + cardiac cushion - PMID:15797462 + @@ -269825,7 +85352,7 @@ The modern definition of neurosecretion has evolved to include the release of an endocardial cushions - + @@ -269860,6 +85387,9 @@ The modern definition of neurosecretion has evolved to include the release of an In humans, it exists distinctly only in the embryonic heart, where it is found between the two venae cavae. In the adult, it is incorporated into the wall of the right atrium to form a smooth part called the sinus venarum, also known as the venarum sinus, which is separated from the rest of the atrium by a ridge of fibres called the crista terminalis. The sinus venosus also forms the SA node and the coronary sinus. In the embryo, the thin walls of the sinus venosus are connected below with the right ventricle, and medially with the left atrium, but are free in the rest of their extent. It receives blood from the vitelline vein, umbilical vein and common cardinal vein. It originally starts as a paired structure but shifts towards associating only with the right atrium as the embryonic heart develops. The left portion shrinks in size and eventually forms the coronary sinus and oblique vein of the left atrium, whereas the right part becomes incorporated into the right atrium to form the sinus venarmu In zebrafish, the sinus venosus also acts as a pacemaker and is the first to contract inflow tract + + + AAO:0010505 EHDAA2:0001839 EHDAA:480 @@ -269871,7 +85401,6 @@ The modern definition of neurosecretion has evolved to include the release of an UMLS:C0225857 UMLS:C0231084 VHOG:0000177 - Wikipedia:Sinus_venosus ZFA:0000154 uberon sinus venarum @@ -269884,7 +85413,7 @@ The modern definition of neurosecretion has evolved to include the release of an sinus venosus - http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray465.png + http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray465.png @@ -269895,7 +85424,7 @@ The modern definition of neurosecretion has evolved to include the release of an - VHOG + VHOG @@ -269906,42 +85435,42 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart. - PMID:20735616 - Wikipedia:Sinus_venosus + + Heart region collecting blood from the paired common cardinal veins and delivering to the atrium. One of four components of the heart. The sinus venosus also acts as a pacemaker and is the first to contract. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000154 - TAO - ZFIN:curator + TAO + ZFIN:curator Part of the circulatory system which receives blood from the systemic veins and contracts to pump the blood into the atrium of the heart.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010505 - AAO - AAO:BJB + AAO + AAO:BJB In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000177 - VHOG + VHOG + ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.428 - http://bgee.unil.ch/ @@ -269971,32 +85500,32 @@ The modern definition of neurosecretion has evolved to include the release of an sinus venarum - Wikipedia:Sinus_venosus + sinus venosus cordis - Wikipedia:Sinus_venosus + venarum - Wikipedia:Sinus_venosus + venarum sinus - Wikipedia:Sinus_venosus + venosus - Wikipedia:Sinus_venosus + @@ -270004,7 +85533,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -270069,6 +85597,9 @@ The modern definition of neurosecretion has evolved to include the release of an A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO] When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG] dermal + + + AAO:0000128 BTO:0000294 CALOHA:TS-2076 @@ -270082,11 +85613,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D020405 MIAA:0000153 NCIT:C12701 - SCTID:361696001 TAO:0001119 UMLS:C0011646 VHOG:0000108 - Wikipedia:Dermis XAO:0000217 ZFA:0001119 vertebrate dermis @@ -270100,13 +85629,13 @@ The modern definition of neurosecretion has evolved to include the release of an dermis - http://upload.wikimedia.org/wikipedia/commons/2/23/EpidermisPainted.svg + http://upload.wikimedia.org/wikipedia/commons/2/23/EpidermisPainted.svg - FMA + FMA @@ -270117,7 +85646,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -270128,7 +85657,7 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/The-neural-crest + @@ -270139,33 +85668,33 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]. - Wikipedia:Dermis - ZFIN:curator + + ZFIN:curator A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001119 - TAO - ZFIN:curator + TAO + ZFIN:curator When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000108 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.231-232 see also p.209 and p.228 and Figure 6-1 - http://bgee.unil.ch/ @@ -270177,10 +85706,15 @@ The modern definition of neurosecretion has evolved to include the release of an corium - BTO:0000294 - Wikipedia:Dermis + + + + + corium + BTO:0000294 + @@ -270193,7 +85727,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -270241,6 +85774,8 @@ The modern definition of neurosecretion has evolved to include the release of an subcutaneous subcutaneus BTO has 'subcutis', as part of dermis. We follow FMA in having distinct classes for hypodermis and superficial fascia, and including these as part of the non-skin intgeument. + + BTO:0001314 CALOHA:TS-2366 EMAPA:37505 @@ -270248,7 +85783,6 @@ The modern definition of neurosecretion has evolved to include the release of an NCIT:C33645 TAO:0001136 UMLS:C0278403 - Wikipedia:Hypodermis ZFA:0001136 hypoderm vertebrate hypodermis @@ -270265,13 +85799,13 @@ The modern definition of neurosecretion has evolved to include the release of an hypodermis - http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg + http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg - FMA + FMA @@ -270282,7 +85816,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -270299,16 +85833,16 @@ The modern definition of neurosecretion has evolved to include the release of an Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]. - Wikipedia:Hypodermis + A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells. Le Guellec et al, 2004.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001136 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -270320,13 +85854,13 @@ The modern definition of neurosecretion has evolved to include the release of an BTO has 'subcutis', as part of dermis. We follow FMA in having distinct classes for hypodermis and superficial fascia, and including these as part of the non-skin intgeument. - BTO + BTO EMAPA:37505 - MA:th + MA:th @@ -270344,7 +85878,7 @@ The modern definition of neurosecretion has evolved to include the release of an subcutaneous tissue - Wikipedia:Hypodermis + @@ -270362,7 +85896,7 @@ The modern definition of neurosecretion has evolved to include the release of an tela subcutanea - Wikipedia:Hypodermis + @@ -270398,6 +85932,9 @@ The modern definition of neurosecretion has evolved to include the release of an An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen. An internal organ of the body; especially: one (as the heart, liver, or intestine) located in the great cavity of the trunk proper.[AAO] general anatomical term in FMA. Note that we place the MA class here temporarily, although properly systems should be distinguished from organs. + + + AAO:0010386 BTO:0001491 EHDAA:512 @@ -270407,9 +85944,7 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D014781 NCIT:C28287 RETIRED_EHDAA2:0002201 - SCTID:118760003 UMLS:C0042779 - Wikipedia:Viscus XAO:0003034 visceral organ visceral organ system @@ -270428,24 +85963,24 @@ The modern definition of neurosecretion has evolved to include the release of an An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen. + + BTO:0001491 - Wikipedia:Viscus - https://github.com/obophenotype/mouse-anatomy-ontology/issues/14 An internal organ of the body; especially: one (as the heart, liver, or intestine) located in the great cavity of the trunk proper.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010386 - AAO + AAO BTO:0001491 general anatomical term in FMA. Note that we place the MA class here temporarily, although properly systems should be distinguished from organs. - FMA + FMA @@ -270514,11 +86049,14 @@ The modern definition of neurosecretion has evolved to include the release of an - A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve. + A cardiac atrium that is in the left side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve. Right cardiac chamber which is continuous with the superior vena cava and inferior vena cava.[FMA] The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG] https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern + + + AAO:0010248 BTO:0001703 EHDAA2:0000290 @@ -270526,10 +86064,10 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:7096 MA:0000075 NCIT:C12868 - SCTID:244383003 + OpenCyc:Mx4runNcs6fqEdudWQACs5b6Bw + OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rDJ89oqgPEdudWQACs5b6Bw UMLS:C0225844 VHOG:0000328 - Wikipedia:Right_atrium XAO:0003192 galen:RightAtrium cardiac right atrium @@ -270544,16 +86082,14 @@ The modern definition of neurosecretion has evolved to include the release of an right cardiac atrium - http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb + http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg - A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve. - Wikipedia:Right_atrium - http://orcid.org/0000-0002-6601-2165 + A cardiac atrium that is in the left side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve. + + @@ -270565,11 +86101,11 @@ The modern definition of neurosecretion has evolved to include the release of an The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000328 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 - http://bgee.unil.ch/ @@ -270593,7 +86129,7 @@ The modern definition of neurosecretion has evolved to include the release of an atrium dextrum - Wikipedia:Right_atrium + @@ -270639,6 +86175,9 @@ The modern definition of neurosecretion has evolved to include the release of an The chamber of the heart that receives blood from the lungs[XAO:EJS]. The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG] https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern + + + AAO:0010247 BTO:0001702 EHDAA2:0000275 @@ -270646,10 +86185,10 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:7097 MA:0000074 NCIT:C12869 - SCTID:244387002 + OpenCyc:Mx4rkJN1AagEEdudWQACs5b6Bw + OpenCyc:Mx8Ngh4rvgIFoJwpEbGdrcN5Y29ycB4rDJ89oqgPEdudWQACs5b6Bw UMLS:C0225860 VHOG:0000369 - Wikipedia:Left_atrium XAO:0003191 galen:LeftAtrium atrium sinistrum @@ -270664,16 +86203,14 @@ The modern definition of neurosecretion has evolved to include the release of an left cardiac atrium - http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb + http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve. - Wikipedia:Left_atrium - http://orcid.org/0000-0002-6601-2165 + + @@ -270691,11 +86228,11 @@ The modern definition of neurosecretion has evolved to include the release of an The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000369 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 - http://bgee.unil.ch/ @@ -270707,7 +86244,7 @@ The modern definition of neurosecretion has evolved to include the release of an atrium sinistrum - Wikipedia:Left_atrium + @@ -270776,6 +86313,9 @@ The modern definition of neurosecretion has evolved to include the release of an The muscular chamber on the right and in front of the left ventricle. It generally receives venous blood from the right atrium and conveys it into the pulmonary artery. [(1988)_Dorian_AF, Amsterdam, Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B._Anatomy, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier's_Encyclopaedic_Dictionary_of_Medicine][VHOG] https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern In mammals continuous with the pulmonary arteries + + + BTO:0001630 CALOHA:TS-0443 EHDAA2:0000196 @@ -270783,10 +86323,10 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:7098 MA:0000093 NCIT:C12870 - SCTID:244384009 + OpenCyc:Mx4rRMlc0KgNEdudWQACs5b6Bw + OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rvVjj1pwpEbGdrcN5Y29ycA UMLS:C0225883 VHOG:0000717 - Wikipedia:Right_ventricle galen:RightVentricle cardiac right ventricle right ventricle @@ -270799,9 +86339,7 @@ The modern definition of neurosecretion has evolved to include the release of an heart right ventricle - http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb + http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg @@ -270812,7 +86350,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:17276708 + @@ -270823,22 +86361,22 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm A cardiac ventricle that is in the right side of the heart. - http://orcid.org/0000-0002-6601-2165 + The muscular chamber on the right and in front of the left ventricle. It generally receives venous blood from the right atrium and conveys it into the pulmonary artery. [(1988)_Dorian_AF, Amsterdam, Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B._Anatomy, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier's_Encyclopaedic_Dictionary_of_Medicine][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000717 - VHOG - http://bgee.unil.ch/ + VHOG + @@ -270862,7 +86400,7 @@ The modern definition of neurosecretion has evolved to include the release of an ventriculus dexter - Wikipedia:Right_ventricle + @@ -270894,6 +86432,9 @@ The modern definition of neurosecretion has evolved to include the release of an One of four heart chambers.[TAO] One of two chambers of the heart which receive blood from the veins and forces it by muscular contration to the ventricle.[AAO] In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...).[well established][VHOG] + + + AAO:0010246 BTO:0000903 CALOHA:TS-0437 @@ -270908,11 +86449,9 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000496 MESH:D006325 NCIT:C12728 - SCTID:261405004 TAO:0000471 UMLS:C0018792 VHOG:0000175 - Wikipedia:Heart_atrium ZFA:0000471 galen:Atrium atria @@ -270933,36 +86472,36 @@ The modern definition of neurosecretion has evolved to include the release of an Cardiac chamber in which blood enters the heart. - Wikipedia:Heart_atrium - http://orcid.org/0000-0002-6601-2165 + + One of four heart chambers.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000471 - TAO - ZFIN:curator + TAO + ZFIN:curator One of two chambers of the heart which receive blood from the veins and forces it by muscular contration to the ventricle.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010246 - AAO - AAO:BJB + AAO + AAO:BJB In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000175 - VHOG + VHOG + ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.428 - http://bgee.unil.ch/ @@ -270974,7 +86513,7 @@ The modern definition of neurosecretion has evolved to include the release of an atria - + @@ -270986,7 +86525,7 @@ The modern definition of neurosecretion has evolved to include the release of an cardiac atria - + @@ -271024,6 +86563,9 @@ The modern definition of neurosecretion has evolved to include the release of an One of four heart chambers.[TAO] In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...)[well established][VHOG] ventricle + + + AAO:0010249 BTO:0000862 CALOHA:TS-0444 @@ -271038,11 +86580,10 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000497 MESH:D006352 NCIT:C12730 - SCTID:277699000 + OpenCyc:Mx4rvVjj1pwpEbGdrcN5Y29ycA TAO:0000009 UMLS:C0018827 VHOG:0000435 - Wikipedia:Ventricle_(heart) XAO:0003193 ZFA:0000009 galen:Ventricle @@ -271066,42 +86607,42 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN Cardiac chamber through which blood leaves the heart. - Wikipedia:Ventricle_(heart) - http://orcid.org/0000-0002-6601-2165 + + A chamber of the heart that receives blood from one or more atria and pumps it by muscular contraction into the arteries.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010249 - AAO - AAO:BJB + AAO + AAO:BJB One of four heart chambers.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000009 - TAO - ZFIN:curator + TAO + ZFIN:curator In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...)[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000435 - VHOG + VHOG + ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.428 - http://bgee.unil.ch/ @@ -271164,6 +86705,9 @@ The modern definition of neurosecretion has evolved to include the release of an The vertebrate heart initially forms as a tube from a population of precursor cells termed the first heart field (FHF). Cells from the adjacent second heart field (SHF) are then progressively added to the developing heart. In avian and mammalian hearts, the FHF contributes mainly to the left ventricle, whereas the SHF gives rise to the outflow tract and large portions of the right ventricle and atria. Both fields arise from common mesodermal progenitors, although the detailed lineage relationships between FHF and SHF remain uncertain.[well established][VHOG] https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern In mammals continuous with aorta + + + BTO:0001629 CALOHA:TS-0439 EHDAA2:0002178 @@ -271171,10 +86715,10 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:7101 MA:0000092 NCIT:C12871 - SCTID:244385005 + OpenCyc:Mx4rtW8v46gEEdudWQACs5b6Bw + OpenCyc:Mx8Ngh4rvgIFoJwpEbGdrcN5Y29ycB4rvVjj1pwpEbGdrcN5Y29ycA UMLS:C0225897 VHOG:0000718 - Wikipedia:Left_ventricle galen:LeftVentricle cardiac left ventricle left cardiac ventricle @@ -271187,9 +86731,7 @@ The modern definition of neurosecretion has evolved to include the release of an heart left ventricle - http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb + http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg @@ -271200,32 +86742,32 @@ The modern definition of neurosecretion has evolved to include the release of an - GO + GO A cardiac ventricle that is in the left side of the heart. - http://orcid.org/0000-0002-6601-2165 + Thick-walled muscular chamber constituting the left border and apex of the heart. It receives oxygenated blood from the left atrium through the mitral orifice and send it off into the aorta. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000718 - VHOG - http://bgee.unil.ch/ + VHOG + The vertebrate heart initially forms as a tube from a population of precursor cells termed the first heart field (FHF). Cells from the adjacent second heart field (SHF) are then progressively added to the developing heart. In avian and mammalian hearts, the FHF contributes mainly to the left ventricle, whereas the SHF gives rise to the outflow tract and large portions of the right ventricle and atria. Both fields arise from common mesodermal progenitors, although the detailed lineage relationships between FHF and SHF remain uncertain.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000718 - VHOG + VHOG + DOI:10.1126/science.1190181 Stolfi A, Gainous TB, Young JJ, Mori A, Levine M, Christiaen L, Early chordate origins of the vertebrate second heart field. Science (2010) - http://bgee.unil.ch/ @@ -271243,7 +86785,7 @@ The modern definition of neurosecretion has evolved to include the release of an ventriculus sinister cordis - Wikipedia:Left_ventricle + @@ -271283,16 +86825,19 @@ The modern definition of neurosecretion has evolved to include the release of an A cardiac septum that divides the left and right atria of the heart. The partition separating the right and left atria of the heart. [TFD][VHOG] The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG] + + + EHDAA2:0000838 EHDAA:1896 EMAPA:17011 FMA:7108 MA:0000084 NCIT:C32818 - SCTID:362016003 + OpenCyc:Mx4rpd49nLYEEduAAAACs2IKfQ + OpenCyc:Mx4rwGvku5wpEbGdrcN5Y29ycA UMLS:C0225836 VHOG:0000385 - Wikipedia:Interatrial_septum galen:InteratrialSeptum atrial septum atrium septum @@ -271302,33 +86847,33 @@ The modern definition of neurosecretion has evolved to include the release of an interatrial septum - http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png + http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png A cardiac septum that divides the left and right atria of the heart. - http://orcid.org/0000-0002-6601-2165 + The partition separating the right and left atria of the heart. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000385 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/interatrial+septum + VHOG + + The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000385 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 - http://bgee.unil.ch/ @@ -271342,6 +86887,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -271397,59 +86943,59 @@ The modern definition of neurosecretion has evolved to include the release of an The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]. + + ZFA:0000317 - https://sourceforge.net/tracker/?func=detail&aid=2983975&group_id=76834&atid=974957 - https://sourceforge.net/tracker/?func=detail&atid=1205376&aid=2983977&group_id=76834 Skeletal subdivision of the central body axis including vertebrae, notochord, ribs, and sternum.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000093 - VSAO - PSPUB:0000170 + VSAO + PSPUB:0000170 The axial skeleton is formed by the vertebral column, a metameric, semi-flexible, arched bar located in the dorsal part of the trunk, and is formed by a series of cartilaginous or bony vertebrae. It provides suspension for the appendicular skeleton and protection for the spinal nerve cord.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000034 - AAO - AAO:LAP + AAO + AAO:LAP The post-cranial structural components forming the long axis of the vertebrate body; usually consists of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000317 - TAO - ZFIN:curator + TAO + ZFIN:curator The axial musculoskeletal system represents the plesiomorphic locomotor engine of the vertebrate body, playing a central role in locomotion. In craniates, the evolution of the postcranial skeleton is characterized by two major transformations. First, the axial skeleton became increasingly functionally and morphologically regionalized. Second, the axial-based locomotion plesiomorphic for craniates became progressively appendage-based with the evolution of extremities in tetrapods.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000317 - VHOG + VHOG + DOI:10.1186/1742-9994-8-4 Schilling N, Evolution of the axial system in craniates: morphology and function of the perivertebral musculature. Frontiers in Zoology (2011) - http://bgee.unil.ch/ axial skeleton + FMA:71221 - https://github.com/obophenotype/uberon/wiki/The-axial-skeleton EMAPA:37721 - MA:th + MA:th @@ -271483,11 +87029,13 @@ The modern definition of neurosecretion has evolved to include the release of an Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]. - Skeletal subdivision consisting of all the skeletal elements in the pectoral and pelvic appendage complexes.[VSAO] Skeletal system that consists of the paired fins (pectoral or pelvic fins).[TAO] The pectoral and pelvic girdles, which articulate with the axial skeleton, together with their associated limbs, the forelimbs and hind limbs, form the appendicular skeleton.[AAO] ontologies differ in whether they treat the term appendicular skeleton as being the entire set of bones in the limbs, or whether the fore and hind limbs/fins are treated as seperate appendicular skeletons. Here we follow FMA, and treat the appendicular skeleton as the sum total of skeletal elements in the organism (this is evidenced by the fact that in FMA, skeleton of left/right upper/lower limb is part_of a appendicular skeleton, and subtypes of 'subdivision of appendicular skeleton'). We have separate classes such as 'skeleton of limb', and 'skeleton of hindlimb' for the 4 parts of the appendicular skeleton. In future the ZFA/TAO classes may be moved. + + + AAO:0000747 EFO:0000951 EMAPA:32729 @@ -271496,11 +87044,9 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000278 MIAA:0000278 NCIT:C49477 - SCTID:322050006 UMLS:C0222646 VHOG:0001666 VSAO:0000076 - Wikipedia:Appendicular_skeleton XAO:0003166 appendicular skeleton entire appendicular skeleton @@ -271509,55 +87055,54 @@ The modern definition of neurosecretion has evolved to include the release of an skeleton appendiculare UBERON:0002091 - appendicular skeleton https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton - http://upload.wikimedia.org/wikipedia/commons/7/7c/Appendicular_skeleton_diagram.svg + http://upload.wikimedia.org/wikipedia/commons/7/7c/Appendicular_skeleton_diagram.svg Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]. - UBERONREF:0000003 - Wikipedia:Appendicular_skeleton - https://orcid.org/0000-0002-6601-2165 + + + UBERONREF:0000003 Skeletal subdivision consisting of all the skeletal elements in the pectoral and pelvic appendage complexes.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000076 - VSAO - PSPUB:0000170 - https://orcid.org/0000-0002-6601-2165 + VSAO + + PSPUB:0000170 Skeletal system that consists of the paired fins (pectoral or pelvic fins).[TAO] - 2012-08-14 + 2012-08-14 TAO:0000027 - TAO - TAO:wd + TAO + TAO:wd The pectoral and pelvic girdles, which articulate with the axial skeleton, together with their associated limbs, the forelimbs and hind limbs, form the appendicular skeleton.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000747 - AAO - AAO:LAP + AAO + AAO:LAP ontologies differ in whether they treat the term appendicular skeleton as being the entire set of bones in the limbs, or whether the fore and hind limbs/fins are treated as seperate appendicular skeletons. Here we follow FMA, and treat the appendicular skeleton as the sum total of skeletal elements in the organism (this is evidenced by the fact that in FMA, skeleton of left/right upper/lower limb is part_of a appendicular skeleton, and subtypes of 'subdivision of appendicular skeleton'). We have separate classes such as 'skeleton of limb', and 'skeleton of hindlimb' for the 4 parts of the appendicular skeleton. In future the ZFA/TAO classes may be moved. - FMA + FMA @@ -271569,7 +87114,7 @@ The modern definition of neurosecretion has evolved to include the release of an entire appendicular skeleton - https://github.com/obophenotype/uberon/issues/59 + @@ -271581,7 +87126,7 @@ The modern definition of neurosecretion has evolved to include the release of an skeleton appendiculare - Wikipedia:Appendicular_skeleton + @@ -271623,6 +87168,9 @@ The modern definition of neurosecretion has evolved to include the release of an The partition separating the right and left ventricles of the heart. [TFD][VHOG] The two most progressive vertebrate classes, the birds and mammals, have completed the ventricular septum and at long last have completely separated the two blood streams along the length of the major heart chambers. This development has obviously been brought about independently in the two cases, since mammals and birds have evolved independently from primitive reptiles.[well established][VHOG] involves the recruitment of myocardial cells as well as of non- muscular mesenchymal cells (Kaufman and Bard, 1999) + + + BTO:0002483 EFO:0001956 EHDAA:2603 @@ -271630,10 +87178,9 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:7133 MA:0000085 NCIT:C32874 - SCTID:362019005 + OpenCyc:Mx4rwA7lp5wpEbGdrcN5Y29ycA UMLS:C0225870 VHOG:0000386 - Wikipedia:Interventricular_septum galen:InterventricularSeptum heart interventricular septum heart ventricular septum @@ -271652,9 +87199,7 @@ The modern definition of neurosecretion has evolved to include the release of an interventricular septum - http://upload.wikimedia.org/wikipedia/commons/9/96/Gray498.png - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb + http://upload.wikimedia.org/wikipedia/commons/9/96/Gray498.png @@ -271666,21 +87211,21 @@ The modern definition of neurosecretion has evolved to include the release of an The partition separating the right and left ventricles of the heart. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000386 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/interventricular+septum + VHOG + + The two most progressive vertebrate classes, the birds and mammals, have completed the ventricular septum and at long last have completely separated the two blood streams along the length of the major heart chambers. This development has obviously been brought about independently in the two cases, since mammals and birds have evolved independently from primitive reptiles.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000386 - VHOG + VHOG + ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.430 - http://bgee.unil.ch/ @@ -271722,33 +87267,33 @@ The modern definition of neurosecretion has evolved to include the release of an intraventricular septum - Wikipedia:Interventricular_septum + s. interventriculare cordis - Wikipedia:Interventricular_septum + septum inferius - Wikipedia:Interventricular_septum + septum membranaceum - Wikipedia:Interventricular_septum + ventricular septum + MA:0000085 - Wikipedia:Interventricular_septum @@ -271767,6 +87312,9 @@ The modern definition of neurosecretion has evolved to include the release of an mesenteric in Uberon, this term is used in the generic sense, not necessarily restricted to the peritoneum, consistent with FMA. WP: 'In anatomy, the mesentery is the double layer of peritoneum that suspends the jejunum and ileum from the posterior wall of the abdomen. Its meaning, however, is frequently extended to include double layers of peritoneum connecting various components of the abdominal cavity.'. TODO - check. Consider FMA:259286 - Region of mesentery. + + + AAO:0011061 BTO:0001380 EV:0100083 @@ -271774,9 +87322,7 @@ The modern definition of neurosecretion has evolved to include the release of an GAID:21 MESH:D008643 NCIT:C33103 - SCTID:362707009 UMLS:C0025474 - Wikipedia:Mesentery#Mesentery_.28general.29 galen:Mesentery generic mesentery mesentery (generic) @@ -271786,28 +87332,28 @@ The modern definition of neurosecretion has evolved to include the release of an mesentery - http://upload.wikimedia.org/wikipedia/commons/1/19/Gray1038.png + http://upload.wikimedia.org/wikipedia/commons/1/19/Gray1038.png - PMID:28192867 + Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon. + + + FMA:7144 - Wikipedia:Mesentery - Wikipedia:Mesentery#Mesentery_.28general.29 - https://github.com/obophenotype/uberon/issues/85 in Uberon, this term is used in the generic sense, not necessarily restricted to the peritoneum, consistent with FMA. WP: 'In anatomy, the mesentery is the double layer of peritoneum that suspends the jejunum and ileum from the posterior wall of the abdomen. Its meaning, however, is frequently extended to include double layers of peritoneum connecting various components of the abdominal cavity.'. TODO - check. Consider FMA:259286 - Region of mesentery. - FMA + FMA @@ -271819,13 +87365,13 @@ The modern definition of neurosecretion has evolved to include the release of an generic mesentery - Wikipedia:Mesentery + mesentery (generic) - Wikipedia:Mesentery + @@ -271833,7 +87379,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -271858,6 +87403,9 @@ The modern definition of neurosecretion has evolved to include the release of an consider 'integumentary system' for invertebrates MA uses the term skin to refer to what is called here: zone of skin + + + BTO:0001253 CALOHA:TS-0934 EFO:0000962 @@ -271867,9 +87415,8 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D012867 MFMO:0000099 NCIT:C12470 - SCTID:181469002 + OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA UMLS:C1123023 - Wikipedia:Skin XAO:0000023 galen:Skin entire skin @@ -271887,12 +87434,7 @@ The modern definition of neurosecretion has evolved to include the release of an skin of body - http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg - https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Skin.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_M_Skin.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Skin.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Skin.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.3/3d-vh-f-skin.glb + http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg @@ -271909,13 +87451,13 @@ The modern definition of neurosecretion has evolved to include the release of an The organ covering the body that consists of the dermis and epidermis. - UBERON:cjm + UBERON:cjm MA uses the term skin to refer to what is called here: zone of skin - FMA + FMA @@ -271963,13 +87505,14 @@ The modern definition of neurosecretion has evolved to include the release of an The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles. 'Terrestrial vertebrates have divided hearts in which septae separate the oxygenated and deoxygenated blood within the pulmonary and systemic circulations' in GO, septum morphogenesis is part of cardiac chamber morphogenesis; need to add axioms to infer this + + EMAPA:35400 FMA:7180 GAID:562 MA:0000083 MESH:D006346 NCIT:C49485 - SCTID:362014000 UMLS:C0018819 cardiac septa heart septa @@ -272004,20 +87547,20 @@ The modern definition of neurosecretion has evolved to include the release of an cardiac septa - + heart septa - + spiral septa XAO:0004141 - + @@ -272037,6 +87580,9 @@ The modern definition of neurosecretion has evolved to include the release of an Organism subdivision that is the part of the body posterior to the head and anterior to the tail.[AAO] Organism subdivision which is the part of the body posterior to the head and anterior to the tail.[TAO] + + + AAO:0010339 BILA:0000116 BTO:0001493 @@ -272048,10 +87594,9 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000296 MIAA:0000296 NCIT:C33816 - SCTID:262225004 + OpenCyc:Mx4rvVkJjpwpEbGdrcN5Y29ycA TAO:0001115 UMLS:C0460005 - Wikipedia:Torso XAO:0000054 XAO:0003025 ZFA:0001115 @@ -272072,35 +87617,35 @@ The modern definition of neurosecretion has evolved to include the release of an Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present. + TAO:0001115 UBERONREF:0000006 - Wikipedia:Torso ZFA - https://github.com/obophenotype/uberon/issues/378 + pending Organism subdivision that is the part of the body posterior to the head and anterior to the tail.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010339 - AAO - AAO:BJB + AAO + AAO:BJB Organism subdivision which is the part of the body posterior to the head and anterior to the tail.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001115 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -272136,19 +87681,21 @@ The modern definition of neurosecretion has evolved to include the release of an The sensory system subserving the sense of vision. The sensory system used for sight.[AAO] UBERON:0007036 + + + + AAO:0000632 BILA:0000140 EMAPA:36003 FMA:7191 MA:0002444 NCIT:C12888 - SCTID:281831001 + OpenCyc:Mx4rvViCtpwpEbGdrcN5Y29ycA TAO:0001127 UMLS:C0587900 - Wikipedia:Visual_system XAO:0003198 ZFA:0001127 - http://uri.neuinfo.org/nif/nifstd/FMAID_7191 photosensory system visual organ system uberon @@ -272168,10 +87715,10 @@ The modern definition of neurosecretion has evolved to include the release of an The sensory system used for sight.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000632 - AAO - AAO:EJS + AAO + AAO:EJS @@ -272219,7 +87766,7 @@ The modern definition of neurosecretion has evolved to include the release of an vestibulo-auditory system - http://upload.wikimedia.org/wikipedia/commons/d/d2/Anatomy_of_the_Human_Ear.svg + http://upload.wikimedia.org/wikipedia/commons/d/d2/Anatomy_of_the_Human_Ear.svg @@ -272231,16 +87778,16 @@ The modern definition of neurosecretion has evolved to include the release of an The sensory system used for balance and hearing.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000631 - AAO - AAO:EJS + AAO + AAO:EJS EMAPA:37985 - MA:th + MA:th @@ -272303,6 +87850,9 @@ The modern definition of neurosecretion has evolved to include the release of an In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve in case of hemorrhagic shock, especially in animals like horses (not in humans), while recycling iron Neither hagfish nor lampreys possess what might be considered a discrete and condensed spleen. Hagfish possess dispersed lymphoid tissue within the submucosa of the intestine (96) associated with the portal vein (97), whereas lymphoid tissue is associated with the typhlosole portion of the intestine in lampreys (96) It synthesizes antibodies in its white pulp and removes, from blood and lymph node circulation, antibody-coated bacteria along with antibody-coated blood cells + + + AAO:0010395 BTO:0001281 CALOHA:TS-0956 @@ -272316,11 +87866,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D013154 MIAA:0000085 NCIT:C12432 - SCTID:181279003 + OpenCyc:Mx4rvVjgw5wpEbGdrcN5Y29ycA TAO:0000436 UMLS:C0037993 VHOG:0000120 - Wikipedia:Spleen XAO:0000328 ZFA:0000436 galen:Spleen @@ -272334,10 +87883,7 @@ The modern definition of neurosecretion has evolved to include the release of an spleen - https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Spleen.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Spleen.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Spleen.glb - https://upload.wikimedia.org/wikipedia/commons/d/d6/Illu_spleen.jpg + https://upload.wikimedia.org/wikipedia/commons/d/d6/Illu_spleen.jpg @@ -272348,8 +87894,8 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA - MA + FMA + MA @@ -272366,33 +87912,33 @@ The modern definition of neurosecretion has evolved to include the release of an The organ that functions to filter blood and to store red corpuscles and platelets. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0000689 An organ involved in red blood cell filtration and immune response.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010395 - AAO + AAO AAO:BMZ With the advent of clonal selection, the accumulation and segregation of T and B cells in specialized organs for antigen presentation became necessary, and indeed the spleen is found in all jawed vertebrates, but not in agnathans or invertebrates.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000120 - VHOG + VHOG + ISBN:978-0781765190 Paul WE, Fundamental Immunology (2008) p.94 - http://bgee.unil.ch/ Neither hagfish nor lampreys possess what might be considered a discrete and condensed spleen. Hagfish possess dispersed lymphoid tissue within the submucosa of the intestine (96) associated with the portal vein (97), whereas lymphoid tissue is associated with the typhlosole portion of the intestine in lampreys (96) - PMID:20959416 + @@ -272404,7 +87950,7 @@ The modern definition of neurosecretion has evolved to include the release of an lien - Wikipedia:Spleen + @@ -272523,6 +88069,9 @@ The modern definition of neurosecretion has evolved to include the release of an The liver is found in all vertebrates, and is typically the largest visceral organ. Its form varies considerably in different species, and is largely determined by the shape and arrangement of the surrounding organs. Nonetheless, in most species it is divided into right and left lobes; exceptions to this general rule include snakes, where the shape of the body necessitates a simple cigar-like form. The internal structure of the liver is broadly similar in all vertebrates. secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. Only ZFA considers this part_of immune system - we weaken this to an overlaps relation, as in general it's only a subset of cells that have clear immune function. + + + AAO:0010111 BTO:0000759 CALOHA:TS-0564 @@ -272538,11 +88087,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D008099 MIAA:0000097 NCIT:C12392 - SCTID:181268008 + OpenCyc:Mx4rvVimppwpEbGdrcN5Y29ycA TAO:0000123 UMLS:C0023884 VHOG:0000257 - Wikipedia:Liver XAO:0000133 ZFA:0000123 galen:Liver @@ -272558,16 +88106,14 @@ The modern definition of neurosecretion has evolved to include the release of an liver - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Liver.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Liver.glb - https://upload.wikimedia.org/wikipedia/commons/6/64/Leber_Schaf.jpg + https://upload.wikimedia.org/wikipedia/commons/6/64/Leber_Schaf.jpg - BTO - EHDAA2 + BTO + EHDAA2 GO-def @@ -272579,7 +88125,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -272590,7 +88136,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -272601,7 +88147,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -272612,7 +88158,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -272623,7 +88169,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -272645,7 +88191,7 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional @@ -272656,7 +88202,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -272667,47 +88213,47 @@ The modern definition of neurosecretion has evolved to include the release of an - http://www.stembook.org/node/512 + An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. + BTO:0000759 - Wikipedia:Liver Organ which secretes bile and participates in formation of certain blood proteins.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010111 - AAO - AAO:BJB + AAO + AAO:BJB relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO] - 2012-06-20 + 2012-06-20 AAO:0010111 - AAO + AAO All vertebrates possess a liver (reference 1); Later in craniate evolution, an anterior gill arch was transformed into jaws, and many new types of feeding subsequently evolved.(...) A liver evolved that, among its many functions, stores considerable energy as glycogen or lipid (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000257 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.526, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 - http://bgee.unil.ch/ Only ZFA considers this part_of immune system - we weaken this to an overlaps relation, as in general it's only a subset of cells that have clear immune function. - ZFA + ZFA @@ -272719,14 +88265,14 @@ The modern definition of neurosecretion has evolved to include the release of an iecur - Wikipedia:Liver + jecur - Wikipedia:Liver + @@ -272759,6 +88305,9 @@ The modern definition of neurosecretion has evolved to include the release of an The terminal region of the mid intestine is comprised of specialized enterocytes that appear to play a role in mucosal immunity. Wallace et al, 2005.[TAO] Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG] + + + AAO:0010397 BTO:0000651 CALOHA:TS-0942 @@ -272772,11 +88321,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D007421 MIAA:0000047 NCIT:C12386 - SCTID:181250005 + OpenCyc:Mx4rvVjlIJwpEbGdrcN5Y29ycA TAO:0001323 UMLS:C0021852 VHOG:0000055 - Wikipedia:Small_intestine XAO:0000130 ZFA:0001323 galen:SmallIntestine @@ -272795,42 +88343,40 @@ The modern definition of neurosecretion has evolved to include the release of an small intestine - http://upload.wikimedia.org/wikipedia/commons/8/82/Stomach_colon_rectum_diagram.svg - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Small_Intestine.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Small_Intestine.glb + http://upload.wikimedia.org/wikipedia/commons/8/82/Stomach_colon_rectum_diagram.svg 2 - cjm + cjm Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]. - ISBN:0073040584 - Wikipedia:Small_intestine + + ISBN:0073040584 The terminal region of the mid intestine is comprised of specialized enterocytes that appear to play a role in mucosal immunity. Wallace et al, 2005.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001323 - TAO - ZFIN:curator + TAO + ZFIN:curator Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000055 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.566 - http://bgee.unil.ch/ @@ -272842,10 +88388,15 @@ The modern definition of neurosecretion has evolved to include the release of an intestinum tenue - BTO:0000651 - Wikipedia:Small_intestine + + + + + intestinum tenue + BTO:0000651 + @@ -272954,6 +88505,9 @@ The modern definition of neurosecretion has evolved to include the release of an Organ attached to the liver which stores bile and empties into the duodenum via the bile duct as needed for digestion.[AAO] relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO] The presence of a gallbladder appears to be a primitive trait. It is found in most fish and all adult reptiles and amphibians and has been well conserved in mammals, for the most part.[well established][VHOG] + + + AAO:0010114 BTO:0000493 CALOHA:TS-0394 @@ -272968,11 +88522,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D005704 MIAA:0000072 NCIT:C12377 - SCTID:181269000 + OpenCyc:Mx4rvVkGr5wpEbGdrcN5Y29ycA TAO:0000208 UMLS:C0016976 VHOG:0000221 - Wikipedia:Gallbladder XAO:0000135 ZFA:0000208 galen:Gallbladder @@ -272989,14 +88542,14 @@ The modern definition of neurosecretion has evolved to include the release of an Rats do not have a gallbladder, but produce bile. The bile flows directly from the liver through the (hepatic) bile duct into the small intestine (Hebel and Stromberg, 1988) gallbladder - https://upload.wikimedia.org/wikipedia/commons/b/b1/GallbladderAnatomy-en.svg - https://upload.wikimedia.org/wikipedia/commons/f/f4/Abdomal_organs.svg + https://upload.wikimedia.org/wikipedia/commons/b/b1/GallbladderAnatomy-en.svg + https://upload.wikimedia.org/wikipedia/commons/f/f4/Abdomal_organs.svg - BTO + BTO @@ -273007,9 +88560,9 @@ The modern definition of neurosecretion has evolved to include the release of an - MA - ZFA - cjm + MA + ZFA + cjm @@ -273020,13 +88573,13 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional An organ that aids digestion and stores bile produced by the liver[WP]. - Wikipedia:Gallbladder + @@ -273052,37 +88605,37 @@ The modern definition of neurosecretion has evolved to include the release of an Membranous muscular sac in which the bile from the liver remains stored until it is required. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000221 - VHOG - http://bgee.unil.ch/ + VHOG + Organ attached to the liver which stores bile and empties into the duodenum via the bile duct as needed for digestion.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010114 - AAO - AAO:BJB + AAO + AAO:BJB relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO] - 2012-06-20 + 2012-06-20 AAO:0010114 - AAO + AAO The presence of a gallbladder appears to be a primitive trait. It is found in most fish and all adult reptiles and amphibians and has been well conserved in mammals, for the most part.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000221 - VHOG + VHOG + DOI:10.1002/(SICI)1097-0029(19970915)38:6<571::AID-JEMT3>3.0.CO;2-I Oldham-Ott CK, Gilloteaux J, Comparative morphology of the gallbladder and biliary tract in vertebrates: Variation in structure, homology in function and gallstones. Microscopy research and technique (1997) - http://bgee.unil.ch/ @@ -273100,14 +88653,14 @@ The modern definition of neurosecretion has evolved to include the release of an vesica biliaris - Wikipedia:Gallbladder + vesica fellea - Wikipedia:Gallbladder + @@ -273137,6 +88690,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]. + BTO:0000087 CALOHA:TS-1198 EMAPA:36285 @@ -273157,13 +88711,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -273262,133 +88816,133 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition]. - OBOL:automatic + OBOL:automatic esophagus involuntary muscle - OBOL:automatic + OBOL:automatic esophagus non-striated muscle - OBOL:automatic + OBOL:automatic esophagus smooth muscle tissue - OBOL:automatic + OBOL:automatic gullet involuntary muscle - OBOL:automatic + OBOL:automatic gullet non-striated muscle - OBOL:automatic + OBOL:automatic gullet smooth muscle - OBOL:automatic + OBOL:automatic gullet smooth muscle tissue - OBOL:automatic + OBOL:automatic involuntary muscle of esophagus - OBOL:automatic + OBOL:automatic involuntary muscle of gullet - OBOL:automatic + OBOL:automatic involuntary muscle of oesophagus - OBOL:automatic + OBOL:automatic non-striated muscle of esophagus - OBOL:automatic + OBOL:automatic non-striated muscle of gullet - OBOL:automatic + OBOL:automatic non-striated muscle of oesophagus - OBOL:automatic + OBOL:automatic oesophagus involuntary muscle - OBOL:automatic + OBOL:automatic oesophagus non-striated muscle - OBOL:automatic + OBOL:automatic oesophagus smooth muscle tissue - OBOL:automatic + OBOL:automatic smooth muscle of gullet - OBOL:automatic + OBOL:automatic smooth muscle of oesophagus - OBOL:automatic + OBOL:automatic smooth muscle tissue of esophagus - OBOL:automatic + OBOL:automatic smooth muscle tissue of gullet - OBOL:automatic + OBOL:automatic smooth muscle tissue of oesophagus - OBOL:automatic + OBOL:automatic @@ -273444,6 +88998,9 @@ The modern definition of neurosecretion has evolved to include the release of an duodenal In fish, the divisions of the small intestine are not as clear, and the terms anterior intestine or proximal intestine may be used instead of duodenum. In humans, the duodenum is a hollow jointed tube about 10-15 inches (25-38 centimetres) long connecting the stomach to the jejunum. It begins with the duodenal bulb and ends at the ligament of Treitz. + + + AAO:0010402 BTO:0000365 CALOHA:TS-0214 @@ -273457,10 +89014,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D004386 MIAA:0000044 NCIT:C12263 - SCTID:181247007 + OpenCyc:Mx4rv4LJDpwpEbGdrcN5Y29ycA UMLS:C0013303 VHOG:0000052 - Wikipedia:Duodenum XAO:0000236 galen:Duodenum uberon @@ -273473,23 +89029,21 @@ The modern definition of neurosecretion has evolved to include the release of an duodenum - http://upload.wikimedia.org/wikipedia/commons/b/b3/Tractus_intestinalis_duodenum.svg - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Small_Intestine.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Small_Intestine.glb + http://upload.wikimedia.org/wikipedia/commons/b/b3/Tractus_intestinalis_duodenum.svg 3 - cjm + cjm The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one). + ISBN:0815318960 - Wikipedia:Duodenum @@ -273501,24 +89055,24 @@ The modern definition of neurosecretion has evolved to include the release of an The fixed portion of the small intestine deeply lodged in the posterior wall of the abdomen and extending from the pylorus to the beginning of the jejunum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000052 - VHOG - http://bgee.unil.ch/ + VHOG + In fish, the divisions of the small intestine are not as clear, and the terms anterior intestine or proximal intestine may be used instead of duodenum. NCBITaxon:32443 - Wikipedia:Duodenum + In humans, the duodenum is a hollow jointed tube about 10-15 inches (25-38 centimetres) long connecting the stomach to the jejunum. It begins with the duodenal bulb and ends at the ligament of Treitz. NCBITaxon:9606 - Wikipedia:Duodenum + @@ -273565,11 +89119,12 @@ The modern definition of neurosecretion has evolved to include the release of an An ovary that is part of a right side of organism [Automatically generated definition]. https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern + + EMAPA:37367 FMA:7213 MA:0001705 NCIT:C33487 - SCTID:280123002 UMLS:C0227873 uberon UBERON:0002118 @@ -273579,13 +89134,13 @@ The modern definition of neurosecretion has evolved to include the release of an An ovary that is part of a right side of organism [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37367 - MA:th + MA:th @@ -273621,11 +89176,12 @@ The modern definition of neurosecretion has evolved to include the release of an An ovary that is part of a left side of organism [Automatically generated definition]. https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern In some elasmobranchs, the left ovary does not mature, with only the right ovary fully developing. In the primitive jawless fish, and some teleosts, there is only one ovary, formed by the fusion of the paired organs in the embryo + + EMAPA:37366 FMA:7214 MA:0001704 NCIT:C32969 - SCTID:280124008 UMLS:C0227874 uberon UBERON:0002119 @@ -273635,19 +89191,19 @@ The modern definition of neurosecretion has evolved to include the release of an An ovary that is part of a left side of organism [Automatically generated definition]. - OBOL:automatic + OBOL:automatic In some elasmobranchs, the left ovary does not mature, with only the right ovary fully developing. In the primitive jawless fish, and some teleosts, there is only one ovary, formed by the fusion of the paired organs in the embryo - Wikipedia:Ovary#In_other_animals + EMAPA:37366 - MA:th + MA:th @@ -273681,6 +89237,8 @@ The modern definition of neurosecretion has evolved to include the release of an In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound[GO:0021718] The SOC displays a significant interspecies variation, being largest in bats and rodents and smaller in primates. + + BAMS:SOC BIRNLEX:1307 DHBA:12462 @@ -273693,7 +89251,6 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D065832 UMLS:C0175427 VHOG:0001381 - Wikipedia:Superior_olivary_complex neuronames:569 nucleus olivaris superior superior olivary nuclei @@ -273705,7 +89262,7 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0002128 superior olivary complex - http://upload.wikimedia.org/wikipedia/commons/4/46/Gray713.png + http://upload.wikimedia.org/wikipedia/commons/4/46/Gray713.png @@ -273716,32 +89273,32 @@ The modern definition of neurosecretion has evolved to include the release of an - NIFSTD + NIFSTD A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system. + ISBN:0-19-502694-2 - Wikipedia:Superior_olivary_complex - ABA + ABA - ABA + ABA - ABA + ABA @@ -273760,7 +89317,7 @@ The modern definition of neurosecretion has evolved to include the release of an nucleus olivaris superior FMA:72247 - FMA:TA + FMA:TA @@ -273805,6 +89362,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -273824,6 +89382,9 @@ The modern definition of neurosecretion has evolved to include the release of an + + + BAMS:CAE BAMS:LC BIRNLEX:905 @@ -273840,10 +89401,8 @@ The modern definition of neurosecretion has evolved to include the release of an MBA:147 MESH:D008125 NCIT:C97333 - SCTID:369016004 TAO:0000539 UMLS:C0023951 - Wikipedia:Locus_ceruleus ZFA:0000539 neuronames:583 Noradrenergic cell group A6 @@ -273867,7 +89426,7 @@ The modern definition of neurosecretion has evolved to include the release of an locus ceruleus - http://upload.wikimedia.org/wikipedia/commons/7/77/Gray709.png + http://upload.wikimedia.org/wikipedia/commons/7/77/Gray709.png @@ -273879,45 +89438,50 @@ The modern definition of neurosecretion has evolved to include the release of an check ZFA - NIFSTD + NIFSTD The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID]. + GAID:577 GO:0021703 - Wikipedia:Locus_ceruleus - ABA + ABA - ABA + ABA - ABA + ABA - ABA + ABA UMLS:C0023951 BIRNLEX:905 + + + + + UMLS:C0023951 ncithesaurus:Locus_Coeruleus @@ -273949,7 +89513,7 @@ The modern definition of neurosecretion has evolved to include the release of an nucleus caeruleus FMA:72478 - FMA:TA + FMA:TA @@ -273969,7 +89533,7 @@ The modern definition of neurosecretion has evolved to include the release of an loci coeruleus ZFA:0000539 - + @@ -274033,6 +89597,9 @@ The modern definition of neurosecretion has evolved to include the release of an + + + BAMS:SSN BAMS:SuS BIRNLEX:1131 @@ -274043,9 +89610,7 @@ The modern definition of neurosecretion has evolved to include the release of an HBA:9194 MA:0001027 MBA:462 - SCTID:369028007 UMLS:C0175447 - Wikipedia:Superior_salivatory_nucleus neuronames:590 superior salivary nucleus uberon @@ -274056,7 +89621,7 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0002149 superior salivatory nucleus - http://upload.wikimedia.org/wikipedia/commons/6/6b/Gray788.png + http://upload.wikimedia.org/wikipedia/commons/6/6b/Gray788.png @@ -274067,7 +89632,7 @@ The modern definition of neurosecretion has evolved to include the release of an - NIFSTD + NIFSTD @@ -274078,7 +89643,7 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional @@ -274090,61 +89655,61 @@ The modern definition of neurosecretion has evolved to include the release of an - ABA + ABA - ABA + ABA - ABA + ABA - ABA + ABA - ABA + ABA - ABA + ABA - ABA + ABA - ABA + ABA - ABA + ABA EMAPA:37756 - MA:th + MA:th @@ -274229,6 +89794,9 @@ The modern definition of neurosecretion has evolved to include the release of an Part of the heart comprised of thin serous membrane, composed of endothelial tissue, that lines the interior of the heart.[AAO] Tunica intima which has as its parts the endothelium of endocardium and the fibroelastic connective tissue that surrounds the cavity of a cardiac chamber. UBERON:0006225 + + + AAO:0010408 BTO:0000387 CALOHA:TS-2075 @@ -274243,11 +89811,10 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000455 MESH:D004699 NCIT:C13004 - SCTID:362013006 + OpenCyc:Mx4rsWA75K1cEduAAADggVaqvw TAO:0001320 UMLS:C0014124 VHOG:0000084 - Wikipedia:Endocardium XAO:0000066 ZFA:0001320 galen:Endocardium @@ -274263,7 +89830,7 @@ The modern definition of neurosecretion has evolved to include the release of an fixed in GO to reflect FMA. See email to David/Varsha June 18 2010 endocardium - http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png + http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png @@ -274274,7 +89841,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN @@ -274286,19 +89853,19 @@ The modern definition of neurosecretion has evolved to include the release of an Layer that lines the lumen of the heart.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001320 - TAO - ZFIN:curator + TAO + ZFIN:curator Part of the heart comprised of thin serous membrane, composed of endothelial tissue, that lines the interior of the heart.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010408 - AAO - AAO:BJB + AAO + AAO:BJB @@ -274361,10 +89928,10 @@ The modern definition of neurosecretion has evolved to include the release of an Endocardium that is part of the atrium. + EMAPA:32745 FMA:7284 MA:0000077 - SCTID:192001005 TAO:0002169 VHOG:0000606 ZFA:0001614 @@ -274389,55 +89956,55 @@ The modern definition of neurosecretion has evolved to include the release of an Endocardium that is part of the atrium. - ZFIN:curator + ZFIN:curator Cardiac atria endocardium - OBOL:automatic + OBOL:automatic atrium of heart endocardium - OBOL:automatic + OBOL:automatic cardiac atrium endocardium - OBOL:automatic + OBOL:automatic endocardium of Cardiac atria - OBOL:automatic + OBOL:automatic endocardium of atrium of heart - OBOL:automatic + OBOL:automatic endocardium of cardiac atrium - OBOL:automatic + OBOL:automatic endocardium of heart atrium - OBOL:automatic + OBOL:automatic heart atrium endocardium - OBOL:automatic + OBOL:automatic @@ -274472,43 +90039,41 @@ The modern definition of neurosecretion has evolved to include the release of an Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA]. Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata.[well established][VHOG] https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern + + + EHDAA2:0001730 EHDAA:4969 EMAPA:17661 FMA:7309 MA:0000426 NCIT:C33483 - SCTID:361967000 + OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rvVjKy5wpEbGdrcN5Y29ycA UMLS:C0225706 VHOG:0000301 - Wikipedia:Right_lung uberon UBERON:0002167 right lung - http://upload.wikimedia.org/wikipedia/commons/3/32/Gray972.png - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-lung.glb + http://upload.wikimedia.org/wikipedia/commons/3/32/Gray972.png Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA]. - FMA:FMA - Wikipedia:Right_lung + + FMA:FMA Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000301 - VHOG + VHOG + ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.210 - http://bgee.unil.ch/ @@ -274543,43 +90108,41 @@ The modern definition of neurosecretion has evolved to include the release of an Lung which consists of the left upper lobe and left lower lobe.[FMA]. Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata.[well established][VHOG] https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern + + + EHDAA2:0000943 EHDAA:4947 EMAPA:17653 FMA:7310 MA:0000425 NCIT:C32967 - SCTID:361982005 + OpenCyc:Mx8Ngh4rvgIFoJwpEbGdrcN5Y29ycB4rvVjKy5wpEbGdrcN5Y29ycA UMLS:C0225730 VHOG:0000618 - Wikipedia:Left_lung uberon UBERON:0002168 left lung - http://upload.wikimedia.org/wikipedia/commons/d/dd/Gray973.png - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-lung.glb + http://upload.wikimedia.org/wikipedia/commons/d/dd/Gray973.png Lung which consists of the left upper lobe and left lower lobe.[FMA]. - FMA:FMA - Wikipedia:Left_lung + + FMA:FMA Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000618 - VHOG + VHOG + ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.210 - http://bgee.unil.ch/ @@ -274590,6 +90153,319 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The upper conducting airways of the lung; these airways arise from the terminus of the trachea. + + Each of the two primary divisions of the trachea leading respectively into the right and the left lung. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] + bronchial + In humans, the main bronchus is histologically identical to trachea; 2ary and 3ary bronchi are not; epithelium becomes simple columnar, goblet cell number decreases, elastic fibers in lamina propria increases, distribution more uniform. Muscular layer between mucosa and submucosa appears. cartilage rings become discontinuous plates connected by fibrous connective tissue + + + + BTO:0001340 + CALOHA:TS-1229 + EFO:0000932 + EMAPA:32689 + EV:0100041 + FMA:7409 + GAID:346 + MA:0000436 + MAT:0000133 + MESH:D001980 + MIAA:0000133 + NCIT:C12683 + UMLS:C0006255 + VHOG:0000262 + XAO:0000121 + bronchi + bronchial trunk + uberon + bronchial tissue + UBERON:0002185 + + + + + bronchus + http://upload.wikimedia.org/wikipedia/commons/1/18/Respiratory_system_complete_numbered.svg + + + + + The upper conducting airways of the lung; these airways arise from the terminus of the trachea. + ISBN:0-397-51047-0 + MESH:A04.411.125 + MGI:cwg + MP:0002264 + + + + + + Wikipedia + + + + + Each of the two primary divisions of the trachea leading respectively into the right and the left lung. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] + 2012-09-17 + VHOG:0000262 + VHOG + + + + + + UMLS:C0006255 + ncithesaurus:Bronchus + + + + + bronchi + + + + + + bronchial trunk + FMA:7409 + + + + + bronchial tissue + BTO:0001340 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. + bronchiolar + lacks submucosa and cartilage plates; they have 3 layers: mucosa, muscular layer and outer layer + + + + BTO:0002375 + CALOHA:TS-2003 + EHDAA:8171 + EHDAA:8183 + EHDAA:8199 + EHDAA:8221 + EMAPA:32697 + FMA:7410 + MA:0000422 + MESH:D055745 + NCIT:C12684 + OpenCyc:Mx4rvl9iDpwpEbGdrcN5Y29ycA + UMLS:C0006270 + VHOG:0000675 + lobular bronchiole + uberon + bronchioli + bronchiolus + UBERON:0002186 + + + bronchiole + https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png + + + + + + + + + + + MA + + + + + + + + + + + FMA + + + + + + + + + + + ncit + + + + + The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. + ISBN:0-397-51047-0 + MGI:cwg + MP:0002267 + + + + + lacks submucosa and cartilage plates; they have 3 layers: mucosa, muscular layer and outer layer + ISBN:0123813611 + + + + + UMLS:C0006270 + ncithesaurus:Bronchiole + + + + + lobular bronchiole + FMA:7410 + + + + + bronchioli + + + + + + bronchiolus + BTO:0002375 + + + + + + + + + The last conducting structure of non-respiratory bronchioles; after this point, the airways have alveoli in their walls. + + + + + BTO:0003223 + EMAPA:36282 + FMA:7411 + MA:0000424 + NCIT:C33754 + OpenCyc:Mx4rwS7IU5wpEbGdrcN5Y29ycA + UMLS:C0225666 + bronchiolus terminalis + uberon + bronchioli terminalis + terminal bronchiole tube + UBERON:0002187 + + + + terminal bronchiole + https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png + + + + + The last conducting structure of non-respiratory bronchioles; after this point, the airways have alveoli in their walls. + ISBN:0-397-51047-0 + MGI:cwg + MP:0002268 + + + + + UMLS:C0225666 + ncithesaurus:Terminal_Bronchiole + + + + + bronchiolus terminalis + + + + + + bronchioli terminalis + + + + + + @@ -274644,7 +90520,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of adipose tissue that is part of the hypodermis, beneath the dermis. - http://orcid.org/0000-0002-6601-2165 + @@ -274675,7 +90551,7 @@ The modern definition of neurosecretion has evolved to include the release of an panniculus adiposus (tela subcutanea) FMA:74315 - FMA:TA + FMA:TA @@ -274683,7 +90559,7 @@ The modern definition of neurosecretion has evolved to include the release of an panniculus adiposus telae subcutaneae FMA:74315 - FMA:TA + FMA:TA @@ -274734,13 +90610,13 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs. - http://orcid.org/0000-0002-6601-2165 + @@ -274748,7 +90624,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -274782,19 +90658,18 @@ The modern definition of neurosecretion has evolved to include the release of an The dermis, epidermis and hypodermis. in FMA intergument = skin+superficial fascia(hypodermis), skin=dermis+epidermis+hair_nail. Note that the definition provided here excludes the more general sense of the term 'integument' used in invertebrates; consider 'integumental system'. Note that the VSAO class appears to include adnexa by its definition. - Anatomical system that protects the body from damage, comprising the skin and its appendages.[AAO] Surface structure that is the outer protective covering of the body.[VSAO] The outer protective barrier that separates the animal from its aquatic environment. Le Guellec et al, 2004.[TAO] integumental integumentary + AAO:0000239 BTO:0000634 EMAPA:37504 FMA:74657 TAO:0000368 VSAO:0000029 - Wikipedia:Integument ZFA:0000368 galen:Integument dermis plus epidermis plus hypodermis @@ -274809,7 +90684,6 @@ The modern definition of neurosecretion has evolved to include the release of an tegument vertebrate integument UBERON:0002199 - @@ -274819,7 +90693,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -274830,53 +90704,53 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The dermis, epidermis and hypodermis. - Wikipedia:Integument + Anatomical system that protects the body from damage, comprising the skin and its appendages.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000239 - AAO - AAO:EJS + AAO + AAO:EJS Surface structure that is the outer protective covering of the body.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000029 - VSAO - PSPUB:0000170 + VSAO + PSPUB:0000170 The outer protective barrier that separates the animal from its aquatic environment. Le Guellec et al, 2004.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000368 - TAO - ZFIN:curator + TAO + ZFIN:curator EMAPA:37504 - MA:th + MA:th integumentum commune FMA:74657 - FMA:TA + FMA:TA @@ -274951,43 +90825,43 @@ The modern definition of neurosecretion has evolved to include the release of an Vasculature that is part of a head [Automatically generated definition]. - OBOL:automatic + OBOL:automatic adult head vascular network - OBOL:automatic + OBOL:automatic adult head vasculature - OBOL:automatic + OBOL:automatic head vascular network - OBOL:automatic + OBOL:automatic vascular network of adult head - OBOL:automatic + OBOL:automatic vascular network of head - OBOL:automatic + OBOL:automatic vasculature of adult head - OBOL:automatic + OBOL:automatic @@ -275033,43 +90907,119 @@ The modern definition of neurosecretion has evolved to include the release of an A vasculature that is part of a trunk [Automatically generated definition]. - OBOL:automatic + OBOL:automatic torso vascular network - OBOL:automatic + OBOL:automatic torso vasculature - OBOL:automatic + OBOL:automatic trunk vascular network - OBOL:automatic + OBOL:automatic vascular network of torso - OBOL:automatic + OBOL:automatic vascular network of trunk - OBOL:automatic + OBOL:automatic vasculature of torso - OBOL:automatic + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a trachea. + + + + BTO:0002115 + EMAPA:35879 + FMA:7472 + MA:0001860 + NCIT:C49307 + UMLS:C0225586 + submucosa of windpipe + trachea submucosa + tracheal submucosa + windpipe submucosa + uberon + submucous layer of trachea + UBERON:0002202 + + + submucosa of trachea + + + + + A submucosa that is part of a trachea. + OBOL:automatic + + + + + UMLS:C0225586 + ncithesaurus:Trachea_Submucosa + + + + + submucosa of windpipe + OBOL:automatic + + + + + windpipe submucosa + OBOL:automatic + + + + + submucous layer of trachea + BTO:0002115 @@ -275088,6 +91038,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -275105,8 +91056,8 @@ The modern definition of neurosecretion has evolved to include the release of an Vasculature that is part of the eye region. not part of the eye in ZFA. Note this changed to a blood vessel in ZFA + FMA:74743 - SCTID:123846009 TAO:0007057 ZFA:0007057 eye vascular network @@ -275121,8 +91072,6 @@ The modern definition of neurosecretion has evolved to include the release of an vasculature of eye - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb @@ -275139,8 +91088,8 @@ The modern definition of neurosecretion has evolved to include the release of an Vasculature that is part of the eye region. - OBOL:automatic - https://sourceforge.net/tracker/?func=detail&aid=3489658&group_id=76834&atid=994726 + + OBOL:automatic @@ -275152,7 +91101,7 @@ The modern definition of neurosecretion has evolved to include the release of an eye vascular network - OBOL:automatic + OBOL:automatic @@ -275164,7 +91113,7 @@ The modern definition of neurosecretion has evolved to include the release of an vascular network of eye - OBOL:automatic + OBOL:automatic @@ -275173,6 +91122,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -275216,6 +91166,9 @@ The modern definition of neurosecretion has evolved to include the release of an There are more than 50,000 extant vertebrate species, representing over 500 million years of evolution. During that time, the vertebrate musculoskeletal systems have adapted to aquatic, terrestrial, fossorial, and arboreal lifestyles, while simultaneously retaining functionally integrated axial and appendicular skeletal systems.[well established][VHOG] musculoskeletal + + + AAO:0010546 CALOHA:TS-1311 EMAPA:32714 @@ -275225,11 +91178,10 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002418 MESH:D009141 NCIT:C12754 - SCTID:278858007 + OpenCyc:Mx4rQRpVNgAKEdyHxgDggVfs8g UMLS:C0026860 VHOG:0001275 VSAO:0000031 - Wikipedia:Musculoskeletal_system XAO:0000168 musculo-skeletal system uberon @@ -275252,28 +91204,28 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that consists of the muscular and skeletal systems. + VSAO:0000031 - VSAO:curator - https://github.com/obophenotype/uberon/issues/77 + VSAO:curator Anatomical system that provides locomotion and physical support to the organism.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010546 - AAO - AAO:EJS + AAO + AAO:EJS There are more than 50,000 extant vertebrate species, representing over 500 million years of evolution. During that time, the vertebrate musculoskeletal systems have adapted to aquatic, terrestrial, fossorial, and arboreal lifestyles, while simultaneously retaining functionally integrated axial and appendicular skeletal systems.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001275 - VHOG + VHOG + DOI:10.1002/jez.b.21246 Shearman RM, Burke AC, The lateral somitic frontier in ontogeny and phylogeny. Journal of Experimental Zoology (2009) - http://bgee.unil.ch/ @@ -275298,6 +91250,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -275306,12 +91259,12 @@ The modern definition of neurosecretion has evolved to include the release of an Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA]. + + EMAPA:36581 FMA:7496 MA:0000320 - SCTID:58442004 TAO:0005155 - Wikipedia:Cartilaginous_joint ZFA:0005155 articulatio cartilaginea uberon @@ -275325,20 +91278,20 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA]. - FMA:FMA - Wikipedia:Cartilaginous_joint + + FMA:FMA junctura cartilaginea - Wikipedia:Cartilaginous_joint + @@ -275374,15 +91327,16 @@ The modern definition of neurosecretion has evolved to include the release of an Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]. Is a joint that is located at the point of contact of articulating bones allowing movement. The joint has a capsule containing synovial fluid surrounding the articulating bone surfaces.[TAO] + + AEO:0000183 CALOHA:TS-2138 EHDAA2:0003183 FMA:7501 MA:0000322 NCIT:C32461 - SCTID:113234001 + OpenCyc:Mx4rv2bBV5wpEbGdrcN5Y29ycA TAO:0005153 - Wikipedia:Synovial_joint ZFA:0005153 galen:SynovialJoint articulatio synoviale @@ -275401,16 +91355,16 @@ The modern definition of neurosecretion has evolved to include the release of an Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]. + FMA:7501 - Wikipedia:Synovial_joint Is a joint that is located at the point of contact of articulating bones allowing movement. The joint has a capsule containing synovial fluid surrounding the articulating bone surfaces.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005153 - TAO + TAO ZFIN:Curator @@ -275418,14 +91372,14 @@ The modern definition of neurosecretion has evolved to include the release of an diarthroses ZFA:0005153 - + diarthrodial joints ZFA:0005153 - + @@ -275449,6 +91403,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -275469,15 +91424,18 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the coelemic cavity lumen that is enclosed by the walls of the thorax. In many species, the diaphragm separates thoracic and abdominal cavities + + + EMAPA:36497 FMA:7565 GAID:93 MA:0000032 MESH:D035423 NCIT:C12905 - SCTID:243949006 + OpenCyc:Mx4rmvyleLfEEduAAAACs6hRXg + OpenCyc:Mx4rvhU_TpwpEbGdrcN5Y29ycA UMLS:C0230139 - Wikipedia:Thoracic_cavity cavitas thoracis cavity of chest cavity of thorax @@ -275490,15 +91448,15 @@ The modern definition of neurosecretion has evolved to include the release of an thoracic cavity - http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray846.png - http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg + http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray846.png + http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg The part of the coelemic cavity lumen that is enclosed by the walls of the thorax. - UBERON:cjm - Wikipedia:Thoracic_cavity + + UBERON:cjm @@ -275510,7 +91468,7 @@ The modern definition of neurosecretion has evolved to include the release of an cavitas thoracis - Wikipedia:Thoracic_cavity + @@ -275574,9 +91532,11 @@ The modern definition of neurosecretion has evolved to include the release of an Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO). TODO - add superclass to unify with VNC? - Part of the central nervous system which descends from the hindbrain within the vertebral column.[AAO] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG] + + + AAO:0010151 BAMS:SP BAMS:Spinal @@ -275598,11 +91558,10 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D013116 MIAA:0000183 NCIT:C12464 - SCTID:180959008 + OpenCyc:Mx4rvVjjk5wpEbGdrcN5Y29ycA TAO:0000075 UMLS:C0037925 VHOG:0000601 - Wikipedia:Spinal_cord XAO:0000020 ZFA:0000075 neuronames:22 @@ -275618,16 +91577,13 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0002240 - spinal cord - http://upload.wikimedia.org/wikipedia/commons/5/58/Spinal_cord_direv.svg - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Spinal_Cord.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Spinal_Cord.glb + http://upload.wikimedia.org/wikipedia/commons/5/58/Spinal_cord_direv.svg @@ -275638,7 +91594,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -275649,7 +91605,7 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional @@ -275660,7 +91616,7 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional @@ -275672,34 +91628,39 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA - https://github.com/obophenotype/uberon/issues/378 + ZFA + pending Part of the central nervous system which descends from the hindbrain within the vertebral column.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010151 - AAO - AAO:BJB + AAO + AAO:BJB (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000601 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.165 - http://bgee.unil.ch/ UMLS:C0037925 BIRNLEX:1709 + + + + + UMLS:C0037925 ncithesaurus:Spinal_Cord @@ -275712,7 +91673,7 @@ The modern definition of neurosecretion has evolved to include the release of an SpC - + @@ -275744,10 +91705,15 @@ The modern definition of neurosecretion has evolved to include the release of an medulla spinalis - BTO:0001279 - Wikipedia:Spinal_cord + + + + + medulla spinalis + BTO:0001279 + @@ -275779,12 +91745,12 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical cluster that is part of the cranium and composed of cartilage and cartilage replacement bones.[TAO] chondrocranial covers the brain dorsally in chondrichthyans + AAO:0010169 EHDAA2:0000243 EMAPA:17681 TAO:0001424 VHOG:0000288 - Wikipedia:Chondrocranium ZFA:0001424 uberon calvarium @@ -275797,26 +91763,26 @@ The modern definition of neurosecretion has evolved to include the release of an Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD]. - Wikipedia:Chondrocranium - http://medical-dictionary.thefreedictionary.com/chondrocranium + + Anatomical cluster that is part of the cranium and composed of cartilage and cartilage replacement bones.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010169 - AAO - AAO:BJB + AAO + AAO:BJB Anatomical cluster that is part of the cranium and composed of cartilage and cartilage replacement bones.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001424 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -275834,214 +91800,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO]. - The anterior horn of the spinal cord (or anterior cornu, or anterior column, or ventral horn) is the ventral (front) grey matter section of the spinal cord. The anterior horn contains motor neurons that affect the axial muscles while the posterior horn receives information regarding touch and sensation. The anterior horn is where the cell bodies of alpha motorneurons are located[Wikipedia:Anterior_horn_of_spinal_cord]. - BAMS:VH - BIRNLEX:2668 - BTO:0005151 - EMAPA:18575 - EMAPA:35794 - FMA:256541 - MA:0001134 - NCIT:C33859 - SCTID:279443000 - TAO:0000702 - UMLS:C0228569 - UMLS:C0228590 - VHOG:0001288 - Wikipedia:Anterior_horn_of_spinal_cord - ZFA:0000702 - neuronames:1751 - anterior gray column of spinal cord - anterior gray horn of spinal cord - anterior grey column of spinal cord - anterior horn - columna grisea anterior medullae spinalis - spinal cord anterior horn - spinal cord ventral horn - ventral gray column of spinal cord - ventral gray matter of spinal cord - ventral grey column of spinal cord - ventral grey horn - ventral horn spinal cord - ventral region of spinal cord - ventral spinal cord - uberon - anterior column - anterior column of the spinal cord - anterior horn (spinal cord) - cornu anterius medullae spinalis - ventral horn of the spinal cord - ventral horns spinal cord - UBERON:0002257 - - - ventral horn of spinal cord - - - - - - - - - - - FMA-abduced-lr - - - - - The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO]. - GO:0021517 - MP:0005112 - Wikipedia:Anterior_horn_of_spinal_cord - https://sourceforge.net/tracker/?group_id=36855&atid=440764 - - - - - The anterior horn of the spinal cord (or anterior cornu, or anterior column, or ventral horn) is the ventral (front) grey matter section of the spinal cord. The anterior horn contains motor neurons that affect the axial muscles while the posterior horn receives information regarding touch and sensation. The anterior horn is where the cell bodies of alpha motorneurons are located[Wikipedia:Anterior_horn_of_spinal_cord]. - Wikipedia:Anterior_horn_of_spinal_cord - - - - - UMLS:C0228569 - BIRNLEX:2668 - - - - - UMLS:C0228590 - ncithesaurus:Ventral_Horn_of_the_Spinal_Cord - - - - - anterior gray column of spinal cord - FMA:256541 - - - - - anterior gray horn of spinal cord - FMA:256541 - - - - - anterior horn - BIRNLEX:2668 - - - - - columna grisea anterior medullae spinalis - FMA:256541 - FMA:TA - - - - - - spinal cord anterior horn - BIRNLEX:2668 - - - - - ventral gray column of spinal cord - FMA:256541 - - - - - ventral gray matter of spinal cord - FMA:256541 - - - - - ventral grey horn - BIRNLEX:2668 - - - - - ventral horn spinal cord - ZFA:0000702 - - - - - anterior column - Wikipedia:Anterior_horn_of_spinal_cord - - - - - anterior column of the spinal cord - Wikipedia:Anterior_horn_of_spinal_cord - - - - - anterior horn (spinal cord) - Wikipedia:Anterior_horn_of_spinal_cord - - - - - cornu anterius medullae spinalis - Wikipedia:Anterior_horn_of_spinal_cord - - - - - - ventral horn of the spinal cord - BAMS:VH - - - - - ventral horns spinal cord - VHOG:0001288 - - - - - @@ -276056,14 +91814,14 @@ The modern definition of neurosecretion has evolved to include the release of an this class denotes the generic structure, and not a specific one such as medullary or pontine reticular formation. It is essential for governing some of the basic functions of higher organisms, and is one of the phylogenetically oldest portions of the brain. FMA has a spinal cord reticular formation but we follow NNs (classical) to restrict this to brainstem structures. This means we also include the MA class for brainstem reticular formation here. FMA has subtypes of reticular formation but we treat this as a composite structure + + BAMS:RET EMAPA:35188 FMA:77719 MA:0003185 MESH:D012154 NLX:143558 - SCTID:361552007 - Wikipedia:Reticular_formation neuronames:1223 brain stem reticular formation brainstem reticular formation @@ -276073,7 +91831,7 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0002275 reticular formation - http://upload.wikimedia.org/wikipedia/commons/9/9b/Gray701.png + http://upload.wikimedia.org/wikipedia/commons/9/9b/Gray701.png @@ -276085,7 +91843,7 @@ The modern definition of neurosecretion has evolved to include the release of an FMA has a spinal cord reticular formation but we follow NNs (classical) to restrict this to brainstem structures. This means we also include the MA class for brainstem reticular formation here. FMA has subtypes of reticular formation but we treat this as a composite structure - FMA + FMA @@ -276098,6 +91856,11 @@ The modern definition of neurosecretion has evolved to include the release of an brainstem reticular formation MA:0003185 + + + + + brainstem reticular formation NeuroNames:1223 @@ -276137,7 +91900,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -276172,13 +91935,13 @@ The modern definition of neurosecretion has evolved to include the release of an Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree). + + FMA:79646 GAID:279 MA:0001273 MESH:D001659 NCIT:C12678 - SCTID:361354009 - Wikipedia:Biliary_system biliary apparatus uberon biliary tract @@ -276186,13 +91949,13 @@ The modern definition of neurosecretion has evolved to include the release of an biliary system - http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png + http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree). - Wikipedia:Biliary_system + @@ -276229,6 +91992,8 @@ The modern definition of neurosecretion has evolved to include the release of an The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA]. The mesentery that originates from the dorsal side of the peritoneal cavity.[TAO] + + EHDAA2:0004560 EHDAA:3019 EHDAA:3033 @@ -276237,9 +92002,7 @@ The modern definition of neurosecretion has evolved to include the release of an EHDAA:3957 EHDAA:3971 FMA:79795 - SCTID:308823000 TAO:0005130 - Wikipedia:Mesentery#Development ZFA:0005130 uberon dorsal mesogastrium @@ -276248,13 +92011,13 @@ The modern definition of neurosecretion has evolved to include the release of an dorsal mesentery - http://upload.wikimedia.org/wikipedia/commons/8/85/Gray985.png + http://upload.wikimedia.org/wikipedia/commons/8/85/Gray985.png - FMA + FMA @@ -276265,36 +92028,36 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA]. - Wikipedia:Dorsal_mesentery - Wikipedia:Mesentery#Development - ZFIN:curator + + + ZFIN:curator The mesentery that originates from the dorsal side of the peritoneal cavity.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005130 - TAO - ZFIN:curator + TAO + ZFIN:curator dorsal mesogastrium - Wikipedia:Dorsal_mesentery + mesenterium dorsale commune - Wikipedia:Dorsal_mesentery + @@ -276305,6 +92068,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -276342,6 +92106,9 @@ The modern definition of neurosecretion has evolved to include the release of an Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain.[TAO] Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,adopted][ZFA:0001707]. the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord[MP] + + + BAMS:BS BIRNLEX:1565 BTO:0000146 @@ -276354,11 +92121,9 @@ The modern definition of neurosecretion has evolved to include the release of an MBA:343 MESH:D001933 NCIT:C12441 - SCTID:180925009 TAO:0002156 UMLS:C0006121 VHOG:0001457 - Wikipedia:Brainstem ZFA:0001707 neuronames:236 brain stem @@ -276377,21 +92142,21 @@ The modern definition of neurosecretion has evolved to include the release of an 'brainstem' is a loose term that sometimes refers to the ventral parts o the brain except for any part of the telencephalon - sometimes it includes the diencephalon or subpallial telencephalon structures (ISBN:0471888893). Here we use it in a more restriced sense, to include only the medulla oblongata, pons (when present) and the midbrain tegmentum (following the ZFA definitions). brainstem - http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray719.png + http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray719.png - ZFA + ZFA Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]. - ISBN:0471888893 + + ISBN:0471888893 MP:0005277 - Wikipedia:Brainstem ZFA:0001707 @@ -276404,9 +92169,9 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA - ABA - https://github.com/obophenotype/uberon/issues/378 + ZFA + + ABA pending @@ -276419,9 +92184,9 @@ The modern definition of neurosecretion has evolved to include the release of an Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain.[TAO] - 2012-08-14 + 2012-08-14 TAO:0002156 - TAO + TAO ISBN:3764351209 @@ -276441,6 +92206,11 @@ The modern definition of neurosecretion has evolved to include the release of an UMLS:C0006121 BIRNLEX:1565 + + + + + UMLS:C0006121 ncithesaurus:Brain_Stem @@ -276459,7 +92229,7 @@ The modern definition of neurosecretion has evolved to include the release of an truncus encephali - Wikipedia:Brainstem + @@ -276535,11 +92305,11 @@ The modern definition of neurosecretion has evolved to include the release of an The atrial part of middle layer of the heart, comprised of involuntary muscle. As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[uncertain][VHOG] + EFO:0003087 EMAPA:32746 FMA:83509 MA:0000081 - SCTID:191910002 TAO:0001374 VHOG:0000602 ZFA:0001374 @@ -276557,18 +92327,18 @@ The modern definition of neurosecretion has evolved to include the release of an The atrial part of middle layer of the heart, comprised of involuntary muscle. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0010493 As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000602 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481 - http://bgee.unil.ch/ @@ -276613,11 +92383,12 @@ The modern definition of neurosecretion has evolved to include the release of an A neural nucleus that is part of the brain. + + EMAPA:35185 FMA:83840 MA:0000811 NCIT:C49346 - SCTID:426465002 UMLS:C1706993 ZFA:0005575 brain nucleus @@ -276630,7 +92401,7 @@ The modern definition of neurosecretion has evolved to include the release of an A neural nucleus that is part of the brain. - http://orcid.org/0000-0002-6601-2165 + @@ -276643,7 +92414,7 @@ The modern definition of neurosecretion has evolved to include the release of an brain nuclei ZFA:0005575 - + @@ -276676,6 +92447,8 @@ The modern definition of neurosecretion has evolved to include the release of an The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue. + + BAMS:Scgrey DHBA:146035048 EMAPA:35792 @@ -276683,7 +92456,6 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000002 NCIT:C32696 NLXANAT:100204 - SCTID:279441003 UMLS:C0475853 neuronames:2619 gray matter of spinal cord @@ -276715,7 +92487,7 @@ The modern definition of neurosecretion has evolved to include the release of an gray matter of spinal cord - OBOL:automatic + OBOL:automatic @@ -276727,20 +92499,20 @@ The modern definition of neurosecretion has evolved to include the release of an spinal cord gray matter - OBOL:automatic + OBOL:automatic spinal cord grey substance - OBOL:automatic + OBOL:automatic substantia grisea medullae spinalis FMA:256580 - FMA:TA + FMA:TA @@ -276749,6 +92521,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -276775,11 +92548,14 @@ The modern definition of neurosecretion has evolved to include the release of an The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities. + check the FMA placement here; ncit placement of body cavity here probably not correct Anatomical space, part of the trunk that contains the pericardial and pleuroperitoneal cavities[ZFA]. The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities[BTO]. In mammals it forms the peritoneal, pleural, and pericardial cavities UBERON:0000169 body cavity + + AEO:0000186 BTO:0001707 EHDAA2:0000267 @@ -276787,7 +92563,6 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:85006 NCIT:C25444 RETIRED_EHDAA2:0003186 - SCTID:361348008 TAO:0001438 UMLS:C0333343 ZFA:0001438 @@ -276805,7 +92580,6 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0002323 - EDITOR_NOTE check the FMA placement here; ncit placement of body cavity here probably not correct coelemic cavity lumen @@ -276817,7 +92591,7 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional @@ -276832,7 +92606,7 @@ The modern definition of neurosecretion has evolved to include the release of an 2012-09-12 ZFA:0001438 ZFA - ZFIN:curator + ZFIN:curator @@ -276929,7 +92703,6 @@ The modern definition of neurosecretion has evolved to include the release of an Any muscle organ that is part of a back [Automatically generated definition]. - EMAPA:35161 FMA:85216 MA:0000496 @@ -276938,7 +92711,6 @@ The modern definition of neurosecretion has evolved to include the release of an muscle organ of back uberon UBERON:0002324 - muscle of back @@ -276950,25 +92722,25 @@ The modern definition of neurosecretion has evolved to include the release of an - prolog + prolog Any muscle organ that is part of a back [Automatically generated definition]. - OBOL:automatic + OBOL:automatic back muscle organ - OBOL:automatic + OBOL:automatic muscle organ of back - OBOL:automatic + OBOL:automatic @@ -277044,6 +92816,10 @@ The modern definition of neurosecretion has evolved to include the release of an In between vertebra the notochord becomes the nucleus pulposus, under it degenerates, and at anterior end in some species its tissue merges with some of the cranial bones.. Some organisms retain a post-embryonic notochord. + + + + AAO:0000327 BTO:0001768 CALOHA:TS-0690 @@ -277057,15 +92833,12 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000281 MESH:D009672 NCIT:C12463 - SCTID:308820002 TAO:0000135 UMLS:C0028439 VHOG:0000199 VSAO:0000032 - Wikipedia:Notochord XAO:0000055 ZFA:0000135 - http://evolution.berkeley.edu/evolibrary/images/history/notochords.jpg embryonic notocord notocord uberon @@ -277076,19 +92849,19 @@ The modern definition of neurosecretion has evolved to include the release of an The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB] notochord - http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png + http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - PMID:15890825 + - VSAO + VSAO @@ -277099,7 +92872,7 @@ The modern definition of neurosecretion has evolved to include the release of an - http://tolweb.org/Chordata/2499 + @@ -277110,7 +92883,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -277121,62 +92894,62 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube. + + + + ISBN:0815318960 - Wikipedia:Notochord - http://tolweb.org/Chordata/2499 - https://github.com/obophenotype/uberon/issues/25 - https://github.com/obophenotype/uberon/issues/271 Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000032 - VSAO - PSPUB:0000170 + VSAO + PSPUB:0000170 Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000135 - TAO - ZFIN:curator + TAO + ZFIN:curator Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000327 - AAO - AAO:LAP + AAO + AAO:LAP relationship type change: differentiates_from mesoderm (AAO:0000304) CHANGED TO: develops_from mesoderm (UBERON:0000926)[AAO] - 2012-06-20 + 2012-06-20 AAO:0000327 - AAO + AAO (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (3) a stiff, longitudinal rod of turgid cells along the dorsal part of the body that is called a notochord (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000199 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 - http://bgee.unil.ch/ @@ -277194,7 +92967,7 @@ The modern definition of neurosecretion has evolved to include the release of an notochorda - Wikipedia:Notochord + @@ -277203,6 +92976,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -277234,7 +93008,7 @@ The modern definition of neurosecretion has evolved to include the release of an Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. - EDITOR_NOTE currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk + currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk Post-cranial axial segments which form sclerotome and dermomyotome.[AAO] Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO] @@ -277244,6 +93018,8 @@ The modern definition of neurosecretion has evolved to include the release of an (...) cephalocordates and craniates belong to a group known as Somitichordata. Somitichordate synapomorphies include (1) somites (...) (reference 1); The idea that the last common ancestor of bilaterian animals (Urbilateria) was segmented has been raised recently on evidence coming from comparative molecular embryology (reference 2).[well established][VHOG] somitic mesodermal cluster + + AAO:0010569 AEO:0001015 BTO:0001558 @@ -277260,7 +93036,6 @@ The modern definition of neurosecretion has evolved to include the release of an TAO:0000155 UMLS:C0376449 VHOG:0000191 - Wikipedia:Somite XAO:0000058 ZFA:0000155 uberon @@ -277276,13 +93051,13 @@ The modern definition of neurosecretion has evolved to include the release of an When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248] somite - http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png + http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - EHDAA2 + EHDAA2 @@ -277304,72 +93079,72 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. - DOI:10.1111/j.1439-0426.2012.01987.x - Wikipedia:Somite + + - PMID:17237766 + Post-cranial axial segments which form sclerotome and dermomyotome.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010569 - AAO - AAO:EJS + AAO + AAO:EJS Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000155 - TAO - ZFIN:curator + TAO + ZFIN:curator relationship loss: develops_from paraxial mesenchyme (TAO:0000942)[TAO] - 2012-08-14 + 2012-08-14 TAO:0000155 - TAO + TAO relationship type change: OBO_REL:part_of trunk (TAO:0001115) CHANGED TO: develops_from trunk (UBERON:0002100)[TAO] - 2012-08-14 + 2012-08-14 TAO:0000155 - TAO + TAO relationship type change: part_of paraxial mesoderm (AAO:0010568) CHANGED TO: develops_from paraxial mesoderm (UBERON:0003077)[AAO] - 2012-06-20 + 2012-06-20 AAO:0010569 - AAO + AAO (...) cephalocordates and craniates belong to a group known as Somitichordata. Somitichordate synapomorphies include (1) somites (...) (reference 1); The idea that the last common ancestor of bilaterian animals (Urbilateria) was segmented has been raised recently on evidence coming from comparative molecular embryology (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000191 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.40, DOI:10.1093/icb/43.1.137 Balavoine G, Adoutte A, The segmented urbilateria: a testable scenario. Integrative and Comparative Biology (2003) - http://bgee.unil.ch/ @@ -277387,25 +93162,25 @@ The modern definition of neurosecretion has evolved to include the release of an epimere - ISBN:0073040584 + ISBN:0073040584 epithelial somite - https://github.com/obophenotype/uberon/wiki/The-neural-crest + somites - + somitus - Wikipedia:Somite + @@ -277414,7 +93189,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -277441,6 +93215,8 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]. + + CALOHA:TS-2057 EHDAA2:0002225 EMAPA:35329 @@ -277448,7 +93224,6 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002411 NCIT:C12957 UMLS:C1516995 - Wikipedia:Exocrine_gland WikipediaCategory:Exocrine_system exocrine glandular system uberon @@ -277461,7 +93236,7 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]. - Wikipedia:Exocrine_gland + @@ -277516,6 +93291,7 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:8612 MA:0002033 NCIT:C116918 + OpenCyc:Mx4rv-6d0ZwpEbGdrcN5Y29ycA VHOG:0001134 galen:PulmonaryTrunk pulmonary artery (trunk) @@ -277528,47 +93304,231 @@ The modern definition of neurosecretion has evolved to include the release of an pulmonary trunk - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb - https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png + https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png - MA + MA An arterial trunk which is continuous with the heart and branches into the pulmonary arteries. - http://orcid.org/0000-0002-6601-2165 + An arterial trunk with origin from the right ventricle of the heart, and dividing into the right and left pulmonary arteries, which enter the corresponding lungs and branch with the bronchi. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001134 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/pulmonary+trunk + VHOG + + As in birds, the conus arteriosus split during embryonic development in mammals to produce the pulmonary trunk and single aortic trunk of the adult.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001134 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481 - http://bgee.unil.ch/ main pulmonary artery - Wikipedia:Pulmonary_artery + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A lamina propria that is part of a bronchus [Automatically generated definition]. + + EMAPA:35194 + FMA:86619 + MA:0001836 + NCIT:C49212 + UMLS:C1707054 + bronchi lamina propria + bronchi lamina propria mucosa + bronchi lamina propria mucosae + bronchial trunk lamina propria + bronchial trunk lamina propria mucosa + bronchial trunk lamina propria mucosae + bronchus lamina propria + bronchus lamina propria mucosa + bronchus lamina propria mucosae + lamina propria mucosa of bronchi + lamina propria mucosa of bronchial trunk + lamina propria mucosa of bronchus + lamina propria mucosae of bronchi + lamina propria mucosae of bronchial trunk + lamina propria mucosae of bronchus + lamina propria of bronchi + lamina propria of bronchial trunk + uberon + bronchial lamina propria + UBERON:0002338 + lamina propria of bronchus + + + + + + + + + + + true + + + + + + A lamina propria that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C1707054 + ncithesaurus:Bronchus_Lamina_Propria + + + + + bronchi lamina propria + OBOL:automatic + + + + + bronchi lamina propria mucosa + OBOL:automatic + + + + + bronchi lamina propria mucosae + OBOL:automatic + + + + + bronchial trunk lamina propria + OBOL:automatic + + + + + bronchial trunk lamina propria mucosa + OBOL:automatic + + + + + bronchial trunk lamina propria mucosae + OBOL:automatic + + + + + bronchus lamina propria mucosa + OBOL:automatic + + + + + bronchus lamina propria mucosae + OBOL:automatic + + + + + lamina propria mucosa of bronchi + OBOL:automatic + + + + + lamina propria mucosa of bronchial trunk + OBOL:automatic + + + + + lamina propria mucosa of bronchus + OBOL:automatic + + + + + lamina propria mucosae of bronchi + OBOL:automatic + + + + + lamina propria mucosae of bronchial trunk + OBOL:automatic + + + + + lamina propria mucosae of bronchus + OBOL:automatic + + + + + lamina propria of bronchi + OBOL:automatic + + + + + lamina propria of bronchial trunk + OBOL:automatic + + + + + bronchial lamina propria + EMAPA:35194 @@ -277616,12 +93576,15 @@ The modern definition of neurosecretion has evolved to include the release of an A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. - EDITOR_NOTE consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams). + consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams). A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO] Migratory cell population which delaminates from neural tube, borders surface ectoderm and neural ectoderm, and gives rise to many different tissue types.[AAO] A well developed neural crest population is present in lampreys (Horigome et al. 1999 ; Tomsa & Langeland, 1999) and gnathostomes. chordate fossils from the early Cambrian (Yunnanozoan and Haikouella) with apparent neural-crest derived structures (pharyngeal denticles and pharyngeal skeletons resembling the striped mucocartilage of the branchial bars in lamprey ammocoete larvae), suggests that neural crest arose very early in vertebrate evolution (Chen et al. 1999; Holland & Chen, 2001). The invertebrate chordates apparently lack defini- tive neural crest. One marker of migrating neural crest in some vertebrates, the antibody HNK1, does not recognize any cells in amphioxus embryos (Holland, unpublished). Even so, in both amphioxus and tunicates, cells at the edges of the neural plate and adjacent nonneural ectoderm share some properties of neural crest[PMID:11523831] We conclude that the neural crest is a vertebrate novelty, but that neural crest cells and their derivatives evolved and diversified in a step-wise fashion - first by elaboration of neural plate border cells, then by the innovation or co-option of new or ancient metazoan cell fates.[well established][VHOG] + + + AAO:0010578 BTO:0001764 CALOHA:TS-0676 @@ -277633,11 +93596,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D009432 MIAA:0000066 NCIT:C34222 - SCTID:361462002 TAO:0000045 UMLS:C0027789 VHOG:0000057 - Wikipedia:Neural_crest XAO:0000048 ZFA:0000045 neuronames:1366 @@ -277651,8 +93612,8 @@ The modern definition of neurosecretion has evolved to include the release of an Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells. neural crest - http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png - https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png + http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png + https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png @@ -277663,8 +93624,8 @@ The modern definition of neurosecretion has evolved to include the release of an - XAO - https://github.com/obophenotype/uberon/wiki/The-neural-crest + + XAO @@ -277676,7 +93637,7 @@ The modern definition of neurosecretion has evolved to include the release of an Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells - ISBN:0073040584 + ISBN:0073040584 @@ -277687,7 +93648,7 @@ The modern definition of neurosecretion has evolved to include the release of an - BTO + BTO @@ -277698,7 +93659,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:11523831 + @@ -277720,7 +93681,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:11523831 + @@ -277732,42 +93693,42 @@ The modern definition of neurosecretion has evolved to include the release of an - ISBN:0073040584 - PMID:17377535 + + ISBN:0073040584 A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000045 - TAO - ZFIN:curator + TAO + ZFIN:curator Migratory cell population which delaminates from neural tube, borders surface ectoderm and neural ectoderm, and gives rise to many different tissue types.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010578 - AAO - AAO:EJS + AAO + AAO:EJS A well developed neural crest population is present in lampreys (Horigome et al. 1999 ; Tomsa & Langeland, 1999) and gnathostomes. chordate fossils from the early Cambrian (Yunnanozoan and Haikouella) with apparent neural-crest derived structures (pharyngeal denticles and pharyngeal skeletons resembling the striped mucocartilage of the branchial bars in lamprey ammocoete larvae), suggests that neural crest arose very early in vertebrate evolution (Chen et al. 1999; Holland & Chen, 2001). The invertebrate chordates apparently lack defini- tive neural crest. One marker of migrating neural crest in some vertebrates, the antibody HNK1, does not recognize any cells in amphioxus embryos (Holland, unpublished). Even so, in both amphioxus and tunicates, cells at the edges of the neural plate and adjacent nonneural ectoderm share some properties of neural crest[PMID:11523831] - PMID:11523831 + We conclude that the neural crest is a vertebrate novelty, but that neural crest cells and their derivatives evolved and diversified in a step-wise fashion - first by elaboration of neural plate border cells, then by the innovation or co-option of new or ancient metazoan cell fates.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000057 - VHOG + VHOG + DOI:10.1111/j.1469-7580.2012.01495.x Hall BK, Gillis JA, Incremental evolution of the neural crest, neural crest cells and neural crest-derived skeletal tissues. J Anat (2012) - http://bgee.unil.ch/ @@ -277780,13 +93741,13 @@ The modern definition of neurosecretion has evolved to include the release of an NC XAO:0000048 - + crista neuralis - Wikipedia:Neural_crest + @@ -277841,7 +93802,7 @@ The modern definition of neurosecretion has evolved to include the release of an Set of all muscles in abdomen. - OBOL:automatic + OBOL:automatic @@ -277901,11 +93862,11 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest. + EFO:0002527 EMAPA:18605 FMA:87217 MA:0002572 - SCTID:181301002 uberon UBERON:0002345 @@ -277933,6 +93894,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + @@ -277943,6 +93910,8 @@ The modern definition of neurosecretion has evolved to include the release of an (...) the ability of ectoderm to produce neuronal cells is a general metazoan feature.[well established][VHOG] neurectodermal we prefer neurectoderm to neural ectoderm since placodal ectoderm is not classified here + + AAO:0011074 BILA:0000039 CALOHA:TS-1212 @@ -277959,7 +93928,6 @@ The modern definition of neurosecretion has evolved to include the release of an TAO:0001120 UMLS:C1518271 VHOG:0000150 - Wikipedia:Neuroectoderm XAO:0000042 ZFA:0001120 neural ectoderm @@ -277974,6 +93942,17 @@ The modern definition of neurosecretion has evolved to include the release of an neurectoderm + + + + + + + + + + ZFA + @@ -277983,23 +93962,23 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/The-neural-crest + Embryonic ectoderm that gives rise to nervous tissue. - Wikipedia:Neuroectoderm + (...) the ability of ectoderm to produce neuronal cells is a general metazoan feature.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000150 - VHOG + VHOG + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) - http://bgee.unil.ch/ @@ -278011,7 +93990,7 @@ The modern definition of neurosecretion has evolved to include the release of an epithelium tubi neuralis; neuroectoderma - Wikipedia:Neuroectoderm + @@ -278060,34 +94039,34 @@ The modern definition of neurosecretion has evolved to include the release of an A thoracic vertebra endochondral element that is composed primarily of a bone tissue. - Thoracic vertebrae in all species are defined as those vertebrae which also carry a pair of ribs, and lie caudal to the cervical vertebrae. In humans, they are distinguished by the presence of facets on the sides of the bodies for articulation with the heads of the ribs, and facets on the transverse processes of all, except the eleventh and twelfth, for articulation with the tubercles of the ribs + + + EMAPA:18011 FMA:9139 GAID:244 MA:0000314 MESH:D013904 NCIT:C12798 - SCTID:181821009 + OpenCyc:Mx4rvdZIBpwpEbGdrcN5Y29ycA UMLS:C0039987 - Wikipedia:Thoracic_vertebrae dorsal vertebra thorax vertebra vertebra of thorax vertebra thoracica uberon UBERON:0002347 - thoracic vertebra - http://upload.wikimedia.org/wikipedia/commons/d/d2/Gray90.png + http://upload.wikimedia.org/wikipedia/commons/d/d2/Gray90.png A thoracic vertebra endochondral element that is composed primarily of a bone tissue. - OBOL:automatic + OBOL:automatic @@ -278099,13 +94078,13 @@ The modern definition of neurosecretion has evolved to include the release of an thorax vertebra - OBOL:automatic + OBOL:automatic vertebra of thorax - OBOL:automatic + OBOL:automatic @@ -278140,10 +94119,13 @@ The modern definition of neurosecretion has evolved to include the release of an A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart. + TODO - check links with UBERON:0002425 visceral serous pericardium. develops from proepicardium. WP:Epicardium -- When considered as a part of the pericardium, it is the inner layer, or visceral pericardium, continuous with the serous layer. External layer of the heart.[TAO] The inner layer of the pericardium that is in contact with the surface of the heart.[AAO] The visceral pericardium apparently produces the pericardial fluid, which lubricates motion between the inner and outer layers of the pericardium. During ventricular contraction, the wave of depolarization moves from endocardial to epicardial surface. [Wikipedia:Epicardium] + + AAO:0010409 EHDAA2:0002202 FMA:9461 @@ -278151,7 +94133,6 @@ The modern definition of neurosecretion has evolved to include the release of an TAO:0005057 UMLS:C0225968 VHOG:0000119 - Wikipedia:Epicardium XAO:0000316 ZFA:0005057 galen:Epicardium @@ -278165,7 +94146,6 @@ The modern definition of neurosecretion has evolved to include the release of an - EDITOR_NOTE TODO - check links with UBERON:0002425 visceral serous pericardium. develops from proepicardium. WP:Epicardium -- When considered as a part of the pericardium, it is the inner layer, or visceral pericardium, continuous with the serous layer. epicardium @@ -278199,31 +94179,31 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart. - http://orcid.org/0000-0002-6601-2165 + External layer of the heart.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005057 - TAO - ZFIN:curator + TAO + ZFIN:curator The inner layer of the pericardium that is in contact with the surface of the heart.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010409 - AAO - AAO:BJB + AAO + AAO:BJB @@ -278267,6 +94247,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -278293,9 +94274,13 @@ The modern definition of neurosecretion has evolved to include the release of an The middle layer of the heart, comprised mainly of striated cardiac muscle fibers. + TODO - check 'Myocardum proper' in FMA. We superclass the more generic class for now. FMA has is_a muscle layer - should we add this? ZFA and BTO both have is_a 'cardiac muscle' (tissue?). But in U we also follow FMA and have cardiac muscle tissue of myocardium (there is also Fibrocollagenous connective tissue of myocardium), which would be identical (see issue-10). Note that GO also treats left/right ventricular cardiac muscle tissue synonymous with ventricular myocardium Robust muscular tunic of the heart which forms the basic part of its walls. Its external surface is covered by the pericardium and its internal one by the endocardium. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] The middle layer of the heart, consisting of cardiac muscle.[AAO] myocardial + + + AAO:0010410 BSA:0000089 BTO:0000901 @@ -278310,12 +94295,11 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000453 MESH:D009206 NCIT:C12371 + OpenCyc:Mx4ro36AFrCvEduAAAAOpmP6tw RETIRED_EHDAA2:0001220 - SCTID:362012001 TAO:0001319 UMLS:C0027061 VHOG:0000083 - Wikipedia:Myocardium XAO:0000065 ZFA:0001319 galen:Myocardium @@ -278329,34 +94313,33 @@ The modern definition of neurosecretion has evolved to include the release of an - EDITOR_NOTE TODO - check 'Myocardum proper' in FMA. We superclass the more generic class for now. FMA has is_a muscle layer - should we add this? ZFA and BTO both have is_a 'cardiac muscle' (tissue?). But in U we also follow FMA and have cardiac muscle tissue of myocardium (there is also Fibrocollagenous connective tissue of myocardium), which would be identical (see issue-10). Note that GO also treats left/right ventricular cardiac muscle tissue synonymous with ventricular myocardium myocardium - http://upload.wikimedia.org/wikipedia/commons/6/6e/Glanzstreifen.jpg + http://upload.wikimedia.org/wikipedia/commons/6/6e/Glanzstreifen.jpg The middle layer of the heart, comprised mainly of striated cardiac muscle fibers. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0005329 Robust muscular tunic of the heart which forms the basic part of its walls. Its external surface is covered by the pericardium and its internal one by the endocardium. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000083 - VHOG - http://bgee.unil.ch/ + VHOG + The middle layer of the heart, consisting of cardiac muscle.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010410 - AAO - AAO:BJB + AAO + AAO:BJB @@ -278381,6 +94364,11 @@ The modern definition of neurosecretion has evolved to include the release of an heart muscle FMA:9462 + + + + + heart muscle ZFA:0001319 @@ -278436,6 +94424,7 @@ The modern definition of neurosecretion has evolved to include the release of an The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO]. EHDAA2 divides the system from the tissue The fish heart displays clear polarity of contraction in a posterior-to-anterior direction. The contraction waves originate in the sinus venosus and terminate in the conus arteriosus. The nodal phenotype persists in the inflow region of the heart, varying from the venosinus to the sinoatrial junctional areas in different species . Similar to the mammalian situation, pacemaker tissue with a lower intrinsic rhythmicity is also found at the atrioventricular junction.[uncertain][VHOG] + EFO:0003909 EHDAA2:0004185 EMAPA:35428 @@ -278443,7 +94432,6 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:9476 MA:0000094 MESH:D006329 - SCTID:281489000 TAO:0005063 VHOG:0001271 ZFA:0005063 @@ -278467,7 +94455,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -278478,7 +94466,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -278489,7 +94477,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -278500,7 +94488,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -278511,7 +94499,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -278522,7 +94510,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -278533,7 +94521,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -278545,11 +94533,11 @@ The modern definition of neurosecretion has evolved to include the release of an The fish heart displays clear polarity of contraction in a posterior-to-anterior direction. The contraction waves originate in the sinus venosus and terminate in the conus arteriosus. The nodal phenotype persists in the inflow region of the heart, varying from the venosinus to the sinoatrial junctional areas in different species . Similar to the mammalian situation, pacemaker tissue with a lower intrinsic rhythmicity is also found at the atrioventricular junction.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001271 - VHOG + VHOG + DOI:10.1152/physrev.00006.2003 Moorman AFM, Christoffels VM, Cardiac Chamber Formation: Development, Genes, and Evolution. Physiological Reviews (2003) - http://bgee.unil.ch/ @@ -278568,7 +94556,7 @@ The modern definition of neurosecretion has evolved to include the release of an complexus stimulans cordis FMA:9476 - FMA:TA + FMA:TA @@ -278588,553 +94576,17 @@ The modern definition of neurosecretion has evolved to include the release of an systema conducente cordis FMA:9476 - FMA:TA + FMA:TA - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]. - - BTO:0004358 - EHDAA2:0004184 - EMAPA:35772 - FMA:9477 - GAID:561 - MA:0000097 - MESH:D012849 - NCIT:C33555 - SCTID:277687007 - TAO:0005069 - UMLS:C0037189 - Wikipedia:Sinoatrial_node - ZFA:0005069 - Koch's node - SA nodal muscle tissue - SA node - cardiac pacemaker - node of Keith-Flack - nodus sinuatrialis - sinoatrial node - sinu-atrial node - sinuatrial nodal muscle tissue - sinuatrial node - sinus node - sinus node of Keith and Flack - uberon - nodus sinuatrialis - UBERON:0002351 - - - - - WP:Heart states: "The SA node is found in all amniotes but not in more primitive vertebrates. In these animals, the muscles of the heart are relatively continuous and the sinus venosus coordinates the beat which passes in a wave through the remaining chambers. Indeed, since the sinus venosus is incorporated into the right atrium in amniotes, it is likely homologous with the SA node. In teleosts, with their vestigial sinus venosus, the main centre of coordination is, instead, in the atrium.". Note however that ZFA has SA node. - sinoatrial node - http://upload.wikimedia.org/wikipedia/commons/d/d2/Sinoatrial_node_low_mag.jpg - http://upload.wikimedia.org/wikipedia/commons/d/de/Sinoatrial_node_2_low_mag.jpg - - - - - - cjm - - - - - - - - - - - ZFA - - - - - The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]. - GO:0003163 - Wikipedia:Sinoatrial_node - - - - - UMLS:C0037189 - ncithesaurus:Sinoatrial_Node - - - - - Koch's node - FMA:9477 - - - - - SA nodal muscle tissue - FMA:9477 - - - - - SA node - FMA:9477 - - - - - cardiac pacemaker - FMA:9477 - - - - - node of Keith-Flack - FMA:9477 - - - - - nodus sinuatrialis - FMA:9477 - FMA:TA - - - - - - sinoatrial node - FMA:9477 - - - - - sinu-atrial node - FMA:9477 - - - - - sinuatrial nodal muscle tissue - FMA:9477 - - - - - sinuatrial node - FMA:9477 - - - - - sinus node - FMA:9477 - - - - - sinus node of Keith and Flack - FMA:9477 - - - - - nodus sinuatrialis - Wikipedia:Sinoatrial_node - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles. - - Three major adaptations, or 'novel cardiac components', that were not present in the ancestor chordate heart tube can be distinguished in the lower vertebrate heart: the atrium, ventricle, and possibly the muscular sinus venosus. Furthermore, within the ventricular component a compact outer myocardial component and an interiorly localized extensive trabecular component can be distinguished. The specific activation of the ventricle adds to its complexity as follows. The depolarizing impulse travels rapidly from the atrioventricular node toward the apex and then toward the conal region, achieving activation from apex to base.[uncertain][VHOG] - BTO:0005689 - EFO:0000276 - EHDAA2:0004183 - EMAPA:35153 - FMA:9478 - GAID:558 - MA:0000095 - MAT:0000498 - MESH:D001283 - NCIT:C32161 - SCTID:277688002 - TAO:0005070 - UMLS:C0004247 - VHOG:0001474 - Wikipedia:Atrioventricular_node - ZFA:0005070 - AV nodal muscle tissue - AV node - Aschoff-Tawara node - atrioventricular nodal muscle tissue - node of Tawara - nodus atrioventricularis - uberon - A-V node - atrio-ventricular node - atriovetricular node - downstream pacemaker - nodus atrioventricularis - UBERON:0002352 - - - - - - atrioventricular node - http://upload.wikimedia.org/wikipedia/commons/5/50/ConductionsystemoftheheartwithouttheHeart.png - http://upload.wikimedia.org/wikipedia/commons/9/92/Gray501.png - - - - - - cjm - - - - - An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles. - UBERON:cjm - Wikipedia:Atrioventricular_node - - - - - Three major adaptations, or 'novel cardiac components', that were not present in the ancestor chordate heart tube can be distinguished in the lower vertebrate heart: the atrium, ventricle, and possibly the muscular sinus venosus. Furthermore, within the ventricular component a compact outer myocardial component and an interiorly localized extensive trabecular component can be distinguished. The specific activation of the ventricle adds to its complexity as follows. The depolarizing impulse travels rapidly from the atrioventricular node toward the apex and then toward the conal region, achieving activation from apex to base.[uncertain][VHOG] - 2012-09-17 - VHOG:0001474 - VHOG - DOI:10.1152/physrev.00006.2003 Moorman AFM, Christoffels VM, Cardiac Chamber Formation: Development, Genes, and Evolution. Physiological Reviews (2003) - http://bgee.unil.ch/ - - - - - UMLS:C0004247 - ncithesaurus:Atrioventricular_Node - - - - - AV nodal muscle tissue - FMA:9478 - - - - - AV node - FMA:9478 - MA:0000095 - - - - - Aschoff-Tawara node - FMA:9478 - - - - - atrioventricular nodal muscle tissue - FMA:9478 - - - - - node of Tawara - FMA:9478 - - - - - nodus atrioventricularis - FMA:TA - - - - - - A-V node - EMAPA:35153 - - - - - atrio-ventricular node - EMAPA:35153 - - - - - atriovetricular node - TAO:0005070 - - - - - downstream pacemaker - ZFA:0005070 - - - - - nodus atrioventricularis - Wikipedia:Atrioventricular_node - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. - UBERON:0004147 - BTO:0001735 - EMAPA:35718 - FMA:9492 - GAID:560 - MA:0000096 - MESH:D011690 - NCIT:C33430 - UMLS:C0034144 - Wikipedia:Purkinje_fiber - Purkinje fiber - cardiac Purkinje fiber - myofibra conducens cardiacus - subendocardial branch - uberon - heart Purkinje fiber - UBERON:0002354 - - - cardiac Purkinje fiber - http://upload.wikimedia.org/wikipedia/commons/9/96/Gray498.png - - - - - - FMA - - - - - - - - - - - FMA - GO - MA - - - - - - - - - - - GO - - - - - - - - - - - https://github.com/obophenotype/uberon/issues/1785 - https://orcid.org/0000-0001-5208-3432 - https://orcid.org/0000-0002-9791-0064 - - - - - - - - - - - FMA - - - - - The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. - GO:0003165 - - - - - UMLS:C0034144 - ncithesaurus:Purkinje_Fiber - - - - - Purkinje fiber - FMA:9492 - MA:0000096 - - - - - cardiac Purkinje fiber - BTO:0001735 - GO:0003165 - - - - - myofibra conducens cardiacus - - - - - - subendocardial branch - Wikipedia:Purkinje_fiber - - - - - heart Purkinje fiber - BTO:0001735 - - - - + @@ -279150,6 +94602,9 @@ The modern definition of neurosecretion has evolved to include the release of an The lower segment of the trunk, inferioposterior to the abdomen proper, in the transition area between the trunk and the lower limbs. pelvic MA and FMA differ in what they consider to be parts of the pelvis. MA includes ureter, urethra, urinary bladder, reproductive organs + + + BTO:0001006 CALOHA:TS-2227 EFO:0002805 @@ -279160,9 +94615,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000030 MESH:D010388 NCIT:C12767 - SCTID:229765004 + OpenCyc:Mx4rvVjiTJwpEbGdrcN5Y29ycA UMLS:C0030797 - Wikipedia:Pelvis galen:Pelvis lesser pelvis pelvic region @@ -279180,15 +94634,15 @@ The modern definition of neurosecretion has evolved to include the release of an The lower segment of the trunk, inferioposterior to the abdomen proper, in the transition area between the trunk and the lower limbs. - Wikipedia:Pelvis - http://orcid.org/0000-0002-6601-2165 - https://github.com/obophenotype/uberon/issues/720 + + + MA and FMA differ in what they consider to be parts of the pelvis. MA includes ureter, urethra, urinary bladder, reproductive organs - MA + MA @@ -279253,11 +94707,11 @@ The modern definition of neurosecretion has evolved to include the release of an Serous membrane which is divided into parietal and visceral serous pericardium. + + EMAPA:19030 FMA:9582 MA:0002739 - SCTID:243954002 - Wikipedia:Serous_pericardium serous portion of pericardium uberon pericardium serosum @@ -279274,7 +94728,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -279285,14 +94739,14 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Serous membrane which is divided into parietal and visceral serous pericardium. - Wikipedia:Serous_pericardium - http://orcid.org/0000-0002-6601-2165 + + @@ -279304,7 +94758,7 @@ The modern definition of neurosecretion has evolved to include the release of an pericardium serosum - Wikipedia:Serous_pericardium + @@ -279349,6 +94803,8 @@ The modern definition of neurosecretion has evolved to include the release of an Serous membrane that forms the lining of the abdominal cavity or the coelom. It covers most of the intra-abdominal organs, supports the abdominal organs, and serves as a conduit for their blood and lymph vessels and nerves. It is composed of a layer of mesothelium.[AAO] peritoneal todo: check MA/EMAPA. + + AAO:0010814 BTO:0001472 CALOHA:TS-2072 @@ -279358,10 +94814,10 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000449 MESH:D010537 NCIT:C12770 + OpenCyc:Mx4rvjJ72ZwpEbGdrcN5Y29ycA TAO:0005120 UMLS:C0031153 VHOG:0001257 - Wikipedia:Peritoneum XAO:0000139 ZFA:0005120 galen:Peritoneum @@ -279372,7 +94828,7 @@ The modern definition of neurosecretion has evolved to include the release of an peritoneum - http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png + http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png @@ -279383,7 +94839,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MP + MP @@ -279395,25 +94851,25 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that lines the peritoneal cavity.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005120 - TAO - ZFIN:curator + TAO + ZFIN:curator Serous membrane that forms the lining of the abdominal cavity or the coelom. It covers most of the intra-abdominal organs, supports the abdominal organs, and serves as a conduit for their blood and lymph vessels and nerves. It is composed of a layer of mesothelium.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010814 - AAO + AAO AAO:JMG todo: check MA/EMAPA. - MA + MA @@ -279434,6 +94890,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -279455,11 +94912,11 @@ The modern definition of neurosecretion has evolved to include the release of an Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA]. most superficial part of pericardium; continuous with the outer adventitial layer of the neighboring great blood vessels. [Wikipedia:Pericardium] + + EMAPA:19029 FMA:9586 MA:0002738 - SCTID:243953008 - Wikipedia:Fibrous_pericardium fibrous portion of pericardium uberon pericardium fibrosum @@ -279472,7 +94929,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -279483,7 +94940,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -279494,7 +94951,7 @@ The modern definition of neurosecretion has evolved to include the release of an - WP + WP @@ -279506,7 +94963,7 @@ The modern definition of neurosecretion has evolved to include the release of an pericardium fibrosum - Wikipedia:Fibrous_pericardium + @@ -279526,7 +94983,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -279542,6 +94998,9 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas. Currently this is logically defined by the system it belongs to, but a better system may be base this on presence/absence of ducts. However, the dual nature of the liver should be taken into consideration here. Consider adding subclasses + + + AEO:0000097 BTO:0000765 CALOHA:TS-2012 @@ -279552,9 +95011,7 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002564 MESH:D005088 NCIT:C12712 - SCTID:115976003 UMLS:C0015282 - Wikipedia:Exocrine_gland ducted gland glandula exocrina uberon @@ -279568,7 +95025,7 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas. - Wikipedia:Exocrine_gland + @@ -279586,7 +95043,7 @@ The modern definition of neurosecretion has evolved to include the release of an glandula exocrina - Wikipedia:Exocrine_gland + @@ -279616,10 +95073,13 @@ The modern definition of neurosecretion has evolved to include the release of an - + Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]. + + + AEO:0000098 BTO:0001488 CALOHA:TS-1300 @@ -279630,9 +95090,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002563 MESH:D004702 NCIT:C12704 - SCTID:40818001 + OpenCyc:Mx4rvbkiRZwpEbGdrcN5Y29ycA UMLS:C0014133 - Wikipedia:Endocrine_gland ductless gland glandula endocrina uberon @@ -279643,13 +95102,13 @@ The modern definition of neurosecretion has evolved to include the release of an endocrine gland - http://upload.wikimedia.org/wikipedia/commons/d/da/Illu_endocrine_system.png + http://upload.wikimedia.org/wikipedia/commons/d/da/Illu_endocrine_system.png Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]. - Wikipedia:Endocrine_gland + @@ -279667,13 +95126,13 @@ The modern definition of neurosecretion has evolved to include the release of an ductless gland - Wikipedia:Ductless_gland + glandulae endocrinae - Wikipedia:Endocrine_gland + @@ -279735,6 +95194,9 @@ The modern definition of neurosecretion has evolved to include the release of an The bone marrow is the hematopoietic organ in all vertebrates but fishes, in which hematopoiesis occurs in the kidney.[well established][VHOG] In adults, marrow in large bones produces new blood cells[Wikipedia:Bone_marrow] + + + AAO:0011007 BTO:0000141 BTO:0000829 @@ -279749,10 +95211,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D001853 MIAA:0000084 NCIT:C12431 - SCTID:421320006 + OpenCyc:Mx4rvVm-FpwpEbGdrcN5Y29ycA UMLS:C0005953 VHOG:0001218 - Wikipedia:Bone_marrow XAO:0000123 galen:BoneMarrow medulla ossea @@ -279766,7 +95227,7 @@ The modern definition of neurosecretion has evolved to include the release of an bone marrow - http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg + http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg @@ -279777,25 +95238,25 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA - MA + FMA + MA The soft tissue that fills the cavities of bones. - MGI:cwg + MGI:cwg MP:0002397 The bone marrow is the hematopoietic organ in all vertebrates but fishes, in which hematopoiesis occurs in the kidney.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001218 - VHOG + VHOG + DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood Cells and Blood Cell Development in the Animal Kingdom. Annual Review of Cell and Developmental Biology (2006) - http://bgee.unil.ch/ @@ -279815,8 +95276,8 @@ The modern definition of neurosecretion has evolved to include the release of an medulla ossium + BTO:0000141 - Wikipedia:Bone_marrow @@ -279873,8 +95334,8 @@ The modern definition of neurosecretion has evolved to include the release of an Any skeletal muscle that is part of the head region. - UBERON:0003899 + AAO:0000107 BTO:0000021 EFO:0003524 @@ -279882,7 +95343,6 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:18172 FMA:9616 MA:0000578 - SCTID:244718003 ZFA:0001652 cephalic muscle cephalic musculature @@ -279898,7 +95358,6 @@ The modern definition of neurosecretion has evolved to include the release of an head muscles UBERON:0002376 - defined generically so could in theory encompass FBbt:00003260 'skeletal muscle of head', or the muscle of a starfish Aristotle's lantern, but we restrict this to craniates. Skeletal muscles of the head originate from the non-segmented head mesoderm (Noden, 1983; Wachtler et al., 1984) @@ -279913,7 +95372,7 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + @@ -279924,13 +95383,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2-abduced + EHDAA2-abduced Any skeletal muscle that is part of the head region. - http://orcid.org/0000-0002-6601-2165 + @@ -279948,7 +95407,7 @@ The modern definition of neurosecretion has evolved to include the release of an head muscle organ - OBOL:automatic + OBOL:automatic @@ -279960,19 +95419,19 @@ The modern definition of neurosecretion has evolved to include the release of an muscle organ of adult head - OBOL:automatic + OBOL:automatic muscle organ of head - OBOL:automatic + OBOL:automatic adult head muscle organ - OBOL:automatic + OBOL:automatic @@ -280011,7 +95470,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any muscle that is part of the cervical (neck) region. - + EMAPA:36050 FMA:9617 GAID:149 @@ -280026,7 +95485,6 @@ The modern definition of neurosecretion has evolved to include the release of an neck muscle organ uberon UBERON:0002377 - muscle of neck @@ -280040,13 +95498,13 @@ The modern definition of neurosecretion has evolved to include the release of an - prolog + prolog Any muscle that is part of the cervical (neck) region. - http://orcid.org/0000-0002-6601-2165 + @@ -280058,25 +95516,25 @@ The modern definition of neurosecretion has evolved to include the release of an muscle organ of neck - OBOL:automatic + OBOL:automatic muscle organ of neck (volume) - OBOL:automatic + OBOL:automatic neck (volume) muscle organ - OBOL:automatic + OBOL:automatic neck muscle organ - OBOL:automatic + OBOL:automatic @@ -280116,7 +95574,9 @@ The modern definition of neurosecretion has evolved to include the release of an Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis. - + + + BTO:0001261 EMAPA:35103 FMA:9620 @@ -280124,9 +95584,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000520 MESH:D000009 NCIT:C32040 - SCTID:361352008 + OpenCyc:Mx4rvlygNJwpEbGdrcN5Y29ycA UMLS:C0000739 - Wikipedia:Abdominal_muscle abdomen muscle abdomen muscle organ abdominal muscle @@ -280135,7 +95594,6 @@ The modern definition of neurosecretion has evolved to include the release of an uberon abdominal wall musculature UBERON:0002378 - muscle of abdomen @@ -280149,13 +95607,13 @@ The modern definition of neurosecretion has evolved to include the release of an - prolog + prolog Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis. - Wikipedia:Abdominal_muscle + @@ -280167,13 +95625,13 @@ The modern definition of neurosecretion has evolved to include the release of an abdomen muscle organ - OBOL:automatic + OBOL:automatic muscle organ of abdomen - OBOL:automatic + OBOL:automatic @@ -280208,6 +95666,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA also has set of connective tissues + + AAO:0000098 BTO:0000421 CALOHA:TS-2009 @@ -280220,7 +95680,7 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D003238 MIAA:0000301 NCIT:C12374 - SCTID:361919005 + OpenCyc:Mx4rv-aBgZwpEbGdrcN5Y29ycA TAO:0001641 UMLS:C0009780 VSAO:0000017 @@ -280238,49 +95698,61 @@ The modern definition of neurosecretion has evolved to include the release of an connective tissue + + + + portion of connective tissue + FMA:9640 + + + + + Bindegewebe + BTO:0000421 + Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance. - GO_REF:0000034 - PSPUB:0000170 + + + GO_REF:0000034 + PSPUB:0000170 VSAO:0000017 - http://dx.plos.org/10.1371/journal.pone.0051070 - https://github.com/obophenotype/uberon/issues/23 One of the four types of tissue in traditional classifications. It is largely a category of exclusion rather than one with a precise definition, but there are certain characteristics shared by all or most tissues in this category, such as involvement in structure and support, derived from mesoderm, and characterized largely by the traits of non-living tissue.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000098 - AAO - AAO:LAP + AAO + AAO:LAP Portion of tissue that consists of mesodermally derived cells and intercellular matrix comprised of protein fibers and carbohydrates, which supports, ensheathes and binds together other tissues.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001641 - TAO - TAO:wd + TAO + TAO:wd Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000017 - VSAO + VSAO GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 - PSPUB:0000170 + PSPUB:0000170 MA also has set of connective tissues - MA + MA @@ -280288,18 +95760,6 @@ The modern definition of neurosecretion has evolved to include the release of an UMLS:C0009780 ncithesaurus:Connective_Tissue - - - - portion of connective tissue - FMA:9640 - - - - - Bindegewebe - BTO:0000421 - @@ -280353,6 +95813,9 @@ The modern definition of neurosecretion has evolved to include the release of an Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. One of the four types of tissue in traditional classifications. Tissue that contains cells with contractile filaments that move past each other and change the size of the cell. Muscle tissue also is separated into three distinct categories.[AAO] + + + AAO:0000306 AEO:0000122 CALOHA:TS-0642 @@ -280362,9 +95825,7 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002437 MESH:D009132 NCIT:C12435 - SCTID:91727004 UMLS:C2328219 - Wikipedia:Muscle_tissue galen:MuscleTissue muscular tissue portion of muscle tissue @@ -280379,18 +95840,18 @@ The modern definition of neurosecretion has evolved to include the release of an Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. + + GO:0060537 - Wikipedia:Muscle_tissue - https://sourceforge.net/tracker/index.php?func=detail&aid=2801266&group_id=36855&atid=440764 One of the four types of tissue in traditional classifications. Tissue that contains cells with contractile filaments that move past each other and change the size of the cell. Muscle tissue also is separated into three distinct categories.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000306 - AAO - AAO:LAP + AAO + AAO:LAP @@ -280442,11 +95903,13 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that is involved in the production of hematopoietic cells. - Anatomical system that consists of the blood and blood forming tissues.[AAO] Zebrafish developmental hematopoiesis shows close correspondence to the development of the mammalian hematopoietic system and is regulated by conserved molecular pathways.[well established][VHOG] hematopoietic In humans this is primarily the bone marrow, spleen, tonsils, and lymph nodes + + + AAO:0011002 BTO:0000570 CALOHA:TS-0449 @@ -280460,11 +95923,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D006413 MIAA:0000022 NCIT:C12909 - SCTID:362587009 TAO:0005023 UMLS:C0018957 VHOG:0001624 - Wikipedia:Haematopoiesis XAO:0000122 ZFA:0005023 haematological system @@ -280478,7 +95939,6 @@ The modern definition of neurosecretion has evolved to include the release of an hemopoietic system UBERON:0002390 - @@ -280493,7 +95953,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -280504,38 +95964,38 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional Anatomical system that is involved in the production of hematopoietic cells. - Wikipedia:Haematopoiesis + Anatomical system that consists of the blood and blood forming tissues.[AAO] - 2012-06-20 + 2012-06-20 AAO:0011002 - AAO - AAO:EJS + AAO + AAO:EJS Zebrafish developmental hematopoiesis shows close correspondence to the development of the mammalian hematopoietic system and is regulated by conserved molecular pathways.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001624 - VHOG + VHOG + DOI:10.1016/j.coph.2010.05.004 Ellett F, Lieschke GJ, Zebrafish as a model for vertebrate hematopoiesis. Current Opinion in Pharmacology (2010) - http://bgee.unil.ch/ In humans this is primarily the bone marrow, spleen, tonsils, and lymph nodes - WP + WP @@ -280598,6 +96058,9 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the excretory ducts in the liver that convey bile between the liver and the intestine. [TFD][VHOG] (...) the amphibian liver has characteristics in common with both fish and terrestrial vertebrates. (...) The histological structure of the liver is similar to that in other vertebrates, with hepatocytes arranged in clusters and cords separated by a meshwork of sinusoids and the presence of the traditional triad of portal venule, hepatic arteriole, and bile duct.[well established][VHOG] we place the ZFA class here as this fits its textual definition and child nodes. We may recommend a label change for ZFA + + + AAO:0011019 BTO:0000122 CALOHA:TS-0075 @@ -280609,11 +96072,10 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000354 MESH:D001652 NCIT:C12376 - SCTID:276157007 + OpenCyc:Mx4rvdCds5wpEbGdrcN5Y29ycA TAO:0001100 UMLS:C0005400 VHOG:0000212 - Wikipedia:Bile_duct XAO:0000134 ZFA:0001100 uberon @@ -280625,7 +96087,7 @@ The modern definition of neurosecretion has evolved to include the release of an bile duct - http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png + http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png @@ -280636,8 +96098,8 @@ The modern definition of neurosecretion has evolved to include the release of an - EMAPA - MA + EMAPA + MA @@ -280648,14 +96110,14 @@ The modern definition of neurosecretion has evolved to include the release of an - XAO + XAO Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine. - Wikipedia:Bile_duct - http://orcid.org/0000-0002-6601-2165 + + @@ -280667,21 +96129,21 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the excretory ducts in the liver that convey bile between the liver and the intestine. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000212 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/bile+duct + VHOG + + (...) the amphibian liver has characteristics in common with both fish and terrestrial vertebrates. (...) The histological structure of the liver is similar to that in other vertebrates, with hepatocytes arranged in clusters and cords separated by a meshwork of sinusoids and the presence of the traditional triad of portal venule, hepatic arteriole, and bile duct.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000212 - VHOG + VHOG + DOI:10.1053/ax.2000.7133 Crawshaw GJ, Weinkle TK, Clinical and pathological aspects of the amphibian liver. Seminars in Avian and Exotic Pet Medicine (2000) - http://bgee.unil.ch/ @@ -280748,39 +96210,39 @@ The modern definition of neurosecretion has evolved to include the release of an The triangular flat bone of the nasal septum. - Dermal bone that underlies the mesethmoid and inserts in a fossa on the anteroventral surface of the parasphenoid.[TAO] Paired, palatal bones of intramembranous origin that lie ventral to the olfactory region and help to floor the nasal capsules.[AAO] relationship loss: overlaps autopalatine-vomer joint (TAO:0001784)[TAO] relationship loss: overlaps mesethmoid-vomer joint (TAO:0001680)[TAO] In bony fish, the vomers are flattened, paired, bones forming the anterior part of the roof of the mouth, just behind the premaxillary bones. In many species, they have teeth, supplementing those in the jaw proper; in some extinct species the teeth on the vomers were actually larger than the primary set. In amphibians and reptiles, the vomers become narrower, due to the presence of the enlarged choanae (the inner part of the nostrils) on either side, and they may extend further back in the jaw. They are typically small in birds, where they form the upper hind part of the beak, again being located between the choanae. In mammals, the vomers have become narrower still, and are fused into a single, vertically oriented bone. The development of the hard palate beneath the vomer means that the bone is now located in a nasal chamber, separate from the mouth[WP] The vomer is paired in some taxa (e.g., Amia) while unpaired in others (e.g., teleosts).[TAO] + + + AAO:0000633 FMA:9710 MA:0001496 MESH:D055172 NCIT:C33888 - SCTID:272678009 + OpenCyc:Mx4rv6jKWZwpEbGdrcN5Y29ycA TAO:0000308 UMLS:C0242403 - Wikipedia:Vomer ZFA:0000308 vomer bone uberon prevomer UBERON:0002396 - vomer - http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg + http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg - FMA + FMA @@ -280792,63 +96254,63 @@ The modern definition of neurosecretion has evolved to include the release of an palatal series - ISBN:0073040584 + ISBN:0073040584 The triangular flat bone of the nasal septum. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0000098 Dermal bone that underlies the mesethmoid and inserts in a fossa on the anteroventral surface of the parasphenoid.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000308 - TAO - ZFIN:curator + TAO + ZFIN:curator Paired, palatal bones of intramembranous origin that lie ventral to the olfactory region and help to floor the nasal capsules.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000633 - AAO - AAO:LAP + AAO + AAO:LAP relationship loss: overlaps autopalatine-vomer joint (TAO:0001784)[TAO] - 2012-08-14 + 2012-08-14 TAO:0000308 - TAO + TAO relationship loss: overlaps mesethmoid-vomer joint (TAO:0001680)[TAO] - 2012-08-14 + 2012-08-14 TAO:0000308 - TAO + TAO In bony fish, the vomers are flattened, paired, bones forming the anterior part of the roof of the mouth, just behind the premaxillary bones. In many species, they have teeth, supplementing those in the jaw proper; in some extinct species the teeth on the vomers were actually larger than the primary set. In amphibians and reptiles, the vomers become narrower, due to the presence of the enlarged choanae (the inner part of the nostrils) on either side, and they may extend further back in the jaw. They are typically small in birds, where they form the upper hind part of the beak, again being located between the choanae. In mammals, the vomers have become narrower still, and are fused into a single, vertically oriented bone. The development of the hard palate beneath the vomer means that the bone is now located in a nasal chamber, separate from the mouth[WP] - Wikipedia:Vomer#In_other_animals + The vomer is paired in some taxa (e.g., Amia) while unpaired in others (e.g., teleosts).[TAO] - 2012-09-06 + 2012-09-06 TAO:0000308 - TAO - Curator + TAO + Curator @@ -280910,14 +96372,16 @@ The modern definition of neurosecretion has evolved to include the release of an The outer serous membrane of the pulmonary pleural. + + + EMAPA:16776 FMA:9733 MA:0002488 NCIT:C33273 - SCTID:361998003 + OpenCyc:Mx4rvv2Uq5wpEbGdrcN5Y29ycA UMLS:C0225777 VHOG:0001495 - Wikipedia:Parietal_pleura uberon pleura parietalis UBERON:0002400 @@ -280930,8 +96394,8 @@ The modern definition of neurosecretion has evolved to include the release of an The outer serous membrane of the pulmonary pleural. - UBERON:cjm - Wikipedia:Pulmonary_pleurae + + UBERON:cjm @@ -280943,7 +96407,7 @@ The modern definition of neurosecretion has evolved to include the release of an pleura parietalis - Wikipedia:Parietal_pleura + @@ -281009,12 +96473,14 @@ The modern definition of neurosecretion has evolved to include the release of an Each lung is invested by an exceedingly delicate serous membrane, the pleura, which is arranged in the form of a closed invaginated sac. A portion of the serous membrane covers the surface of the lung and dips into the fissures between its lobes; it is called the pulmonary pleura (or visceral pleura). The visceral pleura is attached directly to the lungs[Wikipedia:Visceral_pleura]. FMA treats this as part of the lungs + + EHDAA2:0002205 EMAPA:16777 FMA:9734 MA:0002489 NCIT:C33881 - SCTID:361997008 + OpenCyc:Mx4rwNFqppwpEbGdrcN5Y29ycA UMLS:C0225776 VHOG:0001496 pleura pulmonalis @@ -281040,26 +96506,26 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs. - UBERON:cjm - Wikipedia:Pulmonary_pleurae + + UBERON:cjm Each lung is invested by an exceedingly delicate serous membrane, the pleura, which is arranged in the form of a closed invaginated sac. A portion of the serous membrane covers the surface of the lung and dips into the fissures between its lobes; it is called the pulmonary pleura (or visceral pleura). The visceral pleura is attached directly to the lungs[Wikipedia:Visceral_pleura]. - Wikipedia:Visceral_pleura + FMA treats this as part of the lungs - FMA + FMA @@ -281072,14 +96538,14 @@ The modern definition of neurosecretion has evolved to include the release of an pleura pulmonalis FMA:9734 - FMA:TA + FMA:TA pleura visceralis - Wikipedia:Visceral_pleura + @@ -281112,6 +96578,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -281147,6 +96614,9 @@ The modern definition of neurosecretion has evolved to include the release of an In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart [of other tetrapods] is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG] The contraction of the diaphragm creates a negative pressure within the pleural cavity which forces the lungs to expand resulting in passive exhalation and active inhalation. This breathing process can be made forceful through the contraction of the external intercostal muscles which forces the rib cage to expand and add to the negative pressure in the pleural cavity causing the lungs to fill with air. The fluid in the cavity provides lubrication and cushioning the EHDAA2 class of the same is not equivalent. See https://github.com/obophenotype/uberon/issues/86 + + + BTO:0004422 EHDAA2:0001475 EMAPA:16773 @@ -281156,10 +96626,9 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000055 MESH:D035422 NCIT:C12840 - SCTID:361999006 + OpenCyc:Mx4rwCKAppwpEbGdrcN5Y29ycA UMLS:C0178802 VHOG:0000581 - Wikipedia:Pleural_cavity cavitas pleuralis uberon cavitum pleuralae @@ -281168,7 +96637,7 @@ The modern definition of neurosecretion has evolved to include the release of an pleural cavity - http://upload.wikimedia.org/wikipedia/commons/a/ab/Gray965.png + http://upload.wikimedia.org/wikipedia/commons/a/ab/Gray965.png @@ -281179,30 +96648,30 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia The fluid-filled cavity that lies between the visceral and parietal pleurae. - Wikipedia:Pleural_cavity - https://github.com/obophenotype/uberon/issues/86 + + In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart [of other tetrapods] is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000581 - VHOG + VHOG + ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206 - http://bgee.unil.ch/ the EHDAA2 class of the same is not equivalent. See https://github.com/obophenotype/uberon/issues/86 - EHDAA2 + EHDAA2 @@ -281214,21 +96683,21 @@ The modern definition of neurosecretion has evolved to include the release of an cavitas pleuralis - Wikipedia:Pleural_cavity + cavitum pleuralae - Wikipedia:Pleural_cavity + cavitum pleurale - Wikipedia:Pleural_cavity + @@ -281237,7 +96706,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -281263,6 +96732,9 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies. The antibody-based immune system defined by the presence of the major histocompatibility complex (MHC), T cell receptor (TCR), B cell receptor (BCR) or recombination activating genes (RAGs) is known beginning from jawed fishes.[well established][VHOG] + + + AAO:0011003 BILA:0000104 BTO:0005810 @@ -281271,11 +96743,10 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002711 MESH:D007107 NCIT:C12735 - SCTID:362590003 + OpenCyc:Mx4rvWNkm5wpEbGdrcN5Y29ycA TAO:0001159 UMLS:C0020962 VHOG:0001247 - Wikipedia:Immune_system XAO:0003152 ZFA:0001159 uberon @@ -281290,17 +96761,17 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies. - Wikipedia:Immune_system + The antibody-based immune system defined by the presence of the major histocompatibility complex (MHC), T cell receptor (TCR), B cell receptor (BCR) or recombination activating genes (RAGs) is known beginning from jawed fishes.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001247 - VHOG + VHOG + PMID:21046016 Dzik JM, The ancestry and cumulative evolution of immune reactions. Acta biochimica Polonica (2010) - http://bgee.unil.ch/ @@ -281362,9 +96833,9 @@ The modern definition of neurosecretion has evolved to include the release of an A double-walled sac containing the heart and the roots of the great vessels. + FMA:9868 RETIRED_EHDAA2:0001443 - SCTID:361326002 TAO:0000054 uberon pericardium @@ -281372,7 +96843,7 @@ The modern definition of neurosecretion has evolved to include the release of an pericardial sac - http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png + http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png @@ -281383,14 +96854,14 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A double-walled sac containing the heart and the roots of the great vessels. - Wikipedia:Pericardium - https://github.com/obophenotype/uberon/issues/86 + + @@ -281398,8 +96869,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -281431,12 +96902,14 @@ The modern definition of neurosecretion has evolved to include the release of an The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium. - Peritoneum that surrounds the heart.[AAO] pericardial In GO the concept of pericardium is developmental implicitly epithelial, but here it represents a multi-tissue structure encompassing the sac (epithelium plus connective) and cavity this class denotes a combination of fibrous PC + PC sac (itself a combination of cavity, epithelium and connective tissue). Many sources use the term 'pericardium' to denote either just the serous membrane (ZFA) or the epithelium (GO) we follow FMA in dividing pericardium into pericardial sac and fibrous pericardium + + + AAO:0010817 BSA:0000090 BTO:0000717 @@ -281451,24 +96924,22 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000454 MESH:D010496 NCIT:C13005 + OpenCyc:Mx4rvoCLgJwpEbGdrcN5Y29ycA RETIRED_EHDAA2:0001443 - SCTID:181295003 TAO:0000054 UMLS:C0031050 VHOG:0001280 - Wikipedia:Pericardium XAO:0004182 ZFA:0000054 galen:Pericardium uberon UBERON:0002407 - pericardium - http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png + http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png @@ -281479,29 +96950,29 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium. - Wikipedia:Pericardium - http://orcid.org/0000-0002-6601-2165 + + Peritoneum that surrounds the heart.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010817 - AAO + AAO AAO:JMG In GO the concept of pericardium is developmental implicitly epithelial, but here it represents a multi-tissue structure encompassing the sac (epithelium plus connective) and cavity - FMA + FMA @@ -281513,7 +96984,7 @@ The modern definition of neurosecretion has evolved to include the release of an we follow FMA in dividing pericardium into pericardial sac and fibrous pericardium - FMA + FMA @@ -281546,16 +97017,17 @@ The modern definition of neurosecretion has evolved to include the release of an Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac. + + + EHDAA:3422 EHDAA:5378 EMAPA:19031 FMA:9870 MA:0000483 NCIT:C94500 - SCTID:243956000 UMLS:C0225969 VHOG:0000537 - Wikipedia:Parietal_pericardium lamina parietalis (pericardii serosum) lamina parietalis pericardii parietal layer of serous pericardium @@ -281566,13 +97038,13 @@ The modern definition of neurosecretion has evolved to include the release of an parietal serous pericardium - http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png + http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac. - http://orcid.org/0000-0002-6601-2165 + @@ -281585,7 +97057,7 @@ The modern definition of neurosecretion has evolved to include the release of an lamina parietalis pericardii FMA:9870 - FMA:TA + FMA:TA @@ -281598,7 +97070,7 @@ The modern definition of neurosecretion has evolved to include the release of an pericardial sac - DOI:10.5962/bhl.title.1013 + @@ -281633,11 +97105,11 @@ The modern definition of neurosecretion has evolved to include the release of an Transudate contained in the pericardial cavity.[FMA]. + BTO:0001016 FMA:9887 MA:0002530 MESH:D000069236 - Wikipedia:Pericardial_fluid uberon UBERON:0002409 @@ -281647,14 +97119,14 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Transudate contained in the pericardial cavity.[FMA]. + FMA:9887 - Wikipedia:Pericardial_fluid @@ -281662,6 +97134,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -281686,6 +97159,10 @@ The modern definition of neurosecretion has evolved to include the release of an Part of the peripheral nervous system which regulates involuntary functions of the body and consists of the sympathetic and parasympathetic system.[AAO] From comparative analyses of craniate brains, a morphotype of the brain in the earliest craniate stock can be constructed. In marked contrast to cephalochordates, the ancestral craniate morphotype had a plethora of unique features, which included a telencephalon with pallial and subpallial parts, paired olfactory bulbs with substantial projections to most or all of the telencephalic pallium, paired lateral eyes and ears, a lateral line system for both electroreception and mechanoreception, spinal cord dorsal root ganglia, and an autonomic nervous system.[well established][VHOG] FMA splits this into peripheral and nervous parts; GO has ANS directly under NS; PNS is a sib + + + + AAO:0000033 BIRNLEX:1123 BTO:0002507 @@ -281699,12 +97176,10 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000219 MESH:D001341 NCIT:C12673 - SCTID:362481007 TAO:0001574 UMLS:C0004388 UMLS:C1305381 VHOG:0000396 - Wikipedia:Autonomic_nervous_system ZFA:0001574 neuronames:2054 autonomic division of peripheral nervous system @@ -281721,13 +97196,13 @@ The modern definition of neurosecretion has evolved to include the release of an autonomic nervous system - http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png + http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png - cjm + cjm @@ -281738,9 +97213,9 @@ The modern definition of neurosecretion has evolved to include the release of an - EMAPA - MA - NIFSTD + EMAPA + MA + NIFSTD ZFA-modified-from-isa @@ -281753,41 +97228,46 @@ The modern definition of neurosecretion has evolved to include the release of an Nervous system including a portion of the central and peripheral systems and presiding over the control and coordination of the vegetative functions of the organism. It innervates smooth and cardiac muscles and glandular tissues and is responsible for many actions which are more or less automatic (e.g. secretion, vasoconstriction etc.). It consists of the sympathetic and parasympathetic nervous systems. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000396 - VHOG - http://bgee.unil.ch/ + VHOG + Part of the peripheral nervous system which regulates involuntary functions of the body and consists of the sympathetic and parasympathetic system.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000033 - AAO - AAO:BJB + AAO + AAO:BJB From comparative analyses of craniate brains, a morphotype of the brain in the earliest craniate stock can be constructed. In marked contrast to cephalochordates, the ancestral craniate morphotype had a plethora of unique features, which included a telencephalon with pallial and subpallial parts, paired olfactory bulbs with substantial projections to most or all of the telencephalic pallium, paired lateral eyes and ears, a lateral line system for both electroreception and mechanoreception, spinal cord dorsal root ganglia, and an autonomic nervous system.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000396 - VHOG + VHOG + DOI:10.1002/1097-0185(20000615)261:3<111::AID-AR6>3.0.CO;2-F Butler AB, Chordate evolution and the origin of craniates: An old brain in a new head. AnaT Rec (New Anat) (2000) - http://bgee.unil.ch/ FMA splits this into peripheral and nervous parts; GO has ANS directly under NS; PNS is a sib - FMA + FMA UMLS:C0004388 BIRNLEX:1123 + + + + + UMLS:C0004388 ncithesaurus:Autonomic_Nervous_System @@ -281812,13 +97292,13 @@ The modern definition of neurosecretion has evolved to include the release of an divisio autonomica systematis nervosi peripherici - FMA:TA + FMA:TA pars autonomica systematis nervosi peripherici - FMA:TA + FMA:TA @@ -281830,13 +97310,13 @@ The modern definition of neurosecretion has evolved to include the release of an ANS - + divisio autonomica systematis nervosi peripherici - Wikipedia:Autonomic_nervous_system + @@ -281899,18 +97379,19 @@ The modern definition of neurosecretion has evolved to include the release of an Endochondral bone that forms around the notochord and is part of the vertebral column.[TAO] Main component of the vertebral column. It consists of two essential parts, a dorsal neural arch and a ventral centrum.[AAO] + + + AAO:0000691 - BTO:0006196 CALOHA:TS-2352 EFO:0001371 EMAPA:32740 FMA:9914 MA:0000309 NCIT:C12933 - SCTID:181817002 + OpenCyc:Mx4rvt2Dh5wpEbGdrcN5Y29ycA TAO:0001189 UMLS:C0549207 - Wikipedia:Vertebra XAO:0004019 ZFA:0001189 galen:Vertebra @@ -281928,47 +97409,41 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. - GO_REF:0000034 + + + GO_REF:0000034 VSAO:0000184 - http://dx.plos.org/10.1371/journal.pone.0051070 - http://orcid.org/0000-0002-6601-2165 - Wikipedia + Wikipedia Endochondral bone that forms around the notochord and is part of the vertebral column.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001189 - TAO - ZFIN:curator + TAO + ZFIN:curator Main component of the vertebral column. It consists of two essential parts, a dorsal neural arch and a ventral centrum.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000691 - AAO + AAO AAO:Pugener_and_Maglia_2008 - - - - BTO:0006196 - https://orcid.org/0000-0003-4423-4370 - @@ -281979,8 +97454,8 @@ The modern definition of neurosecretion has evolved to include the release of an vertebrae - PHENOSCAPE:ad - + PHENOSCAPE:ad + @@ -282022,51 +97497,49 @@ The modern definition of neurosecretion has evolved to include the release of an A vertebra that is located in the cervical region of the vertebral column. - In some species, some parts of the skull may be composed of vertebra-like elements, e.g. the occipital bone in humans is composed of four vertebra-like segments. In many vertebrate species, cervical vertebrae are variable in number; however, almost all mammals have seven (including those with very short necks relative to body size, such as elephants or whales, and those with very long necks, such as giraffes). The few exceptions include the manatee and the sloths, of which the two-toed sloth has six cervical vertebrae and the three-toed sloth has up to nine cervical vertebrae. In many species, though not in mammals, the cervical vertebrae bear ribs. In many other groups, such as lizards and saurischian dinosaurs, the cervical ribs are large; in birds they are small and completely fused to the vertebrae. The transverse processes of mammals are homologous to the cervical ribs of other amniotes. Thoracic vertebrae in all species are defined as those vertebrae which also carry a pair of ribs, and lie caudal to the cervical vertebrae. In humans, cervical vertebrae are the smallest of the true vertebrae, and can be readily distinguished from those of the thoracic or lumbar regions by the presence of a foramen (hole) in each transverse process, through which passes the vertebral artery. + + EMAPA:17674 FMA:9915 GAID:235 MA:0000311 MESH:D002574 NCIT:C12693 - SCTID:181820005 - Wikipedia:Cervical_vertebrae XAO:0003076 galen:CervicalVertebra cervical vertebrae uberon vertebrae cervicales UBERON:0002413 - cervical vertebra - http://upload.wikimedia.org/wikipedia/commons/f/f8/Illu_vertebral_column.jpg + http://upload.wikimedia.org/wikipedia/commons/f/f8/Illu_vertebral_column.jpg - true + true A vertebra that is located in the cervical region of the vertebral column. - http://orcid.org/0000-0002-6601-2165 + cervical vertebrae - + vertebrae cervicales - Wikipedia:Cervical_vertebrae + @@ -282107,6 +97580,7 @@ The modern definition of neurosecretion has evolved to include the release of an An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail. Note we also have a subclass post-anal tail, for the chordate specific structure. currently defined very generally, inclusive of caudal fin + AEO:0000109 BILA:0000117 BTO:0001348 @@ -282116,8 +97590,8 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000094 MESH:D013623 MIAA:0000094 + OpenCyc:Mx4rvVjiC5wpEbGdrcN5Y29ycA WBbt:0005741 - Wikipedia:Tail caudal subdivision uberon UBERON:0002415 @@ -282131,14 +97605,14 @@ The modern definition of neurosecretion has evolved to include the release of an An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail. + AEO:0000109 - Wikipedia:Tail caudal subdivision - https://orcid.org/0000-0002-6601-2165 + @@ -282146,8 +97620,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -282176,11 +97650,13 @@ The modern definition of neurosecretion has evolved to include the release of an Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle. - (...) the integument of many tetrapods is reinforced by a morphologically and structurally diverse assemblage of skeletal elements. These elements are widely understood to be derivatives of the once all-encompassing dermal skeleton of stem-gnathostomes (...).[well established][VHOG] UBERON:0007029 + + + AEO:0000154 BILA:0000118 CALOHA:TS-1299 @@ -282199,11 +97675,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D034582 MIAA:0000033 NCIT:C12907 - SCTID:361692004 TADS:0000108 UMLS:C0037267 VHOG:0000403 - Wikipedia:Integumentary_system XAO:0000176 galen:Surface integumentary system @@ -282217,7 +97691,6 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0002416 - integumental system @@ -282225,19 +97698,19 @@ The modern definition of neurosecretion has evolved to include the release of an Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle. + + CARO:0002001 - http://orcid.org/0000-0002-6601-2165 - https://github.com/obophenotype/uberon/issues/29 (...) the integument of many tetrapods is reinforced by a morphologically and structurally diverse assemblage of skeletal elements. These elements are widely understood to be derivatives of the once all-encompassing dermal skeleton of stem-gnathostomes (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000403 - VHOG + VHOG + DOI:10.1111/j.1469-7580.2008.01043.x Vickaryous MK, Sire JY, The integumentary skeleton of tetrapods: origin, evolution, and development. J Anat (2009) - http://bgee.unil.ch/ @@ -282261,7 +97734,7 @@ The modern definition of neurosecretion has evolved to include the release of an integumentum commune - Wikipedia:Integumentary_system + @@ -282285,11 +97758,11 @@ The modern definition of neurosecretion has evolved to include the release of an The abdominal segment of the torso. + + EMAPA:35104 FMA:259211 MA:0000021 - SCTID:362875007 - Wikipedia:Lumbar uberon abdomen/pelvis/perineum lower body @@ -282302,13 +97775,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The abdominal segment of the torso. - Wikipedia:Lumbar + @@ -282332,7 +97805,7 @@ The modern definition of neurosecretion has evolved to include the release of an lumbar region - https://orcid.org/0000-0002-6601-2165 + @@ -282380,6 +97853,9 @@ The modern definition of neurosecretion has evolved to include the release of an Phylogenetic analysis suggests that cartilage arose independently in cnidarians, hemichordates, vertebrates, arthropods, annelids, brachiopods, and molluscs - or a common ancestor of brachiopods and molluscs (...). Analyses of cartilage as a tissue and of the development of invertebrate cartilages are consistent with homology between invertebrate and vertebrate cartilage. From the discussion above, it will be clear that understanding genetic changes underlying cartilage evolution is key to determining whether the multiple origins of cartilage represent parallel evolution.[well established][VHOG] + + + AAO:0000060 AEO:0000087 BTO:0000206 @@ -282395,12 +97871,11 @@ The modern definition of neurosecretion has evolved to include the release of an MIAA:0000189 NCIT:C12373 NCIT:C32268 - SCTID:309312004 + OpenCyc:Mx4rvVjeOZwpEbGdrcN5Y29ycA TAO:0001501 UMLS:C0007301 VHOG:0001207 VSAO:0000040 - Wikipedia:Cartilage XAO:0000170 ZFA:0005622 galen:Cartilage @@ -282418,70 +97893,70 @@ The modern definition of neurosecretion has evolved to include the release of an Previous: "A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten]." See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W] cartilage tissue - http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg + http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg - https://github.com/obophenotype/uberon/issues/117 + Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts. - GO_REF:0000034 - PSPUB:0000170 + + + + GO_REF:0000034 + PSPUB:0000170 VSAO:0000040 - http://dx.plos.org/10.1371/journal.pone.0051070 - https://github.com/obophenotype/uberon/issues/37 - https://sourceforge.net/p/obo/vertebrate-skeletal-anatomy-vsao-term-requests/5 A type of dense connective tissue. It is composed of cells called chondrocytes which are dispersed in a firm gel-like ground substance, called the matrix. Cartilage is avascular (contains no blood vessels) and nutrients are diffused through the matrix. Cartilage is found in the joints, the rib cage, the ear, the nose, in the throat and between intervertebral disks. It makes up virtually the entire skeleton in chondrichthyes.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000060 - AAO - AAO:LAP + AAO + AAO:LAP Portion of tissue which is connective tissue composed of collagen and/or elastin fibers and chondrocytes. Cartilage is avascular and provides both skeletal functions and a framework upon which bone is deposited.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001501 - TAO - ZFIN:curator + TAO + ZFIN:curator Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000040 - VSAO + VSAO GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 - PSPUB:0000170 + PSPUB:0000170 relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO] - 2012-06-20 + 2012-06-20 AAO:0000060 - AAO + AAO Phylogenetic analysis suggests that cartilage arose independently in cnidarians, hemichordates, vertebrates, arthropods, annelids, brachiopods, and molluscs - or a common ancestor of brachiopods and molluscs (...). Analyses of cartilage as a tissue and of the development of invertebrate cartilages are consistent with homology between invertebrate and vertebrate cartilage. From the discussion above, it will be clear that understanding genetic changes underlying cartilage evolution is key to determining whether the multiple origins of cartilage represent parallel evolution.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001207 - VHOG + VHOG + DOI:10.1111/j.1525-142X.2011.00520.x Hall BK, Parallelism, deep homology, and evo-devo. Evolution and Development (2012) - http://bgee.unil.ch/ @@ -282541,10 +98016,10 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that is part of a skin of body [Automatically generated definition]. check FMA, use plural for now as general class not there + EMAPA:35774 FMA:71878 MA:0000146 - SCTID:110485007 glandulae cutis uberon set of skin glands @@ -282558,14 +98033,14 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that is part of a skin of body [Automatically generated definition]. - OBOL:automatic + OBOL:automatic glandulae cutis FMA:71878 - FMA:TA + FMA:TA @@ -282578,13 +98053,13 @@ The modern definition of neurosecretion has evolved to include the release of an skin glands - + skin glands set - + @@ -282592,7 +98067,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -282635,6 +98110,8 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the digestive system that contains the liver and the biliary system. System responsible for the production and movement of bile[ZFIN:curator]. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. The parts are: liver, bile duct, gall bladder and hepatic duct [GO:0061008] + + AAO:0011056 CALOHA:TS-1308 EFO:0000800 @@ -282649,7 +98126,6 @@ The modern definition of neurosecretion has evolved to include the release of an TAO:0000036 UMLS:C1711359 VHOG:0000294 - Wikipedia:Hepatobiliary_system XAO:0000132 ZFA:0000036 hepaticobiliary system @@ -282667,13 +98143,13 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the digestive system that contains the liver and the biliary system. - http://orcid.org/0000-0002-6601-2165 + System responsible for the production and movement of bile[ZFIN:curator]. - ZFIN:curator + ZFIN:curator @@ -282722,6 +98198,7 @@ The modern definition of neurosecretion has evolved to include the release of an consider including separate class for developmental structure (adult human is stratified; in EHDAA2 is unilaminar) The epithelium that lines the oral cavity. The oral epithelium epithelial cells with many short microvilli as well as mucous cells, rodlet cells and taste buds[ZFIN:ZDB-PUB-060921-12, ZFIN:ZDB-PUB-091204-24]. the avian oral epithelium has the developmental capacity to initiate tooth developmental programs with underlying grafts of non-avian oral ectomesenchyme + AAO:0010357 BTO:0001775 CALOHA:TS-0715 @@ -282759,7 +98236,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues. - https://orcid.org/0000-0002-6601-2165 + @@ -282771,7 +98248,7 @@ The modern definition of neurosecretion has evolved to include the release of an the avian oral epithelium has the developmental capacity to initiate tooth developmental programs with underlying grafts of non-avian oral ectomesenchyme - PMID:16488870 + @@ -282834,13 +98311,13 @@ The modern definition of neurosecretion has evolved to include the release of an Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]. + + EMAPA:16589 EMAPA:19032 FMA:84882 MA:0000484 - SCTID:243955001 VHOG:0000538 - Wikipedia:Visceral_pericardium lamina visceralis pericardii serosi serous visceral pericardium visceral lamina of serous pericardium @@ -282863,7 +98340,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -282874,19 +98351,19 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]. - Wikipedia:Visceral_pericardium + lamina visceralis pericardii serosi - Wikipedia:Epicardium + @@ -282958,62 +98435,62 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a choroid [Automatically generated definition]. - OBOL:automatic + OBOL:automatic blood vessel of choroid - OBOL:automatic + OBOL:automatic blood vessel of choroid coat - OBOL:automatic + OBOL:automatic blood vessel of choroidea - OBOL:automatic + OBOL:automatic blood vessel of posterior uvea - OBOL:automatic + OBOL:automatic choroid blood vessel - OBOL:automatic + OBOL:automatic choroid coat blood vessel - OBOL:automatic + OBOL:automatic choroidea blood vessel - OBOL:automatic + OBOL:automatic posterior uvea blood vessel - OBOL:automatic + OBOL:automatic vasa sanguinea choroideae FMA:76550 - FMA:TA + FMA:TA @@ -283034,11 +98511,11 @@ The modern definition of neurosecretion has evolved to include the release of an Arteries that connect the dorsal aorta and the dorsal longitudinal anastomotic vessel. They run along the vertical myotomal boundaries. At early stages these vessels don't have venous or arteriproperty_value external_definitionmarkers. They form from the primary sprouts from the dorsal aorta[ZFA:0001061]. Few changes of evolutionary significance occur in the branching pattern of the dorsal aorta. All vertebrates have (...) paired intersegmental arteries to the trunk, tail, and paired appendages.[well established][VHOG] UBERON:0006001 + EHDAA2:0000882 EHDAA:4340 EMAPA:17616 MA:0001985 - SCTID:360401001 TAO:0001061 VHOG:0000225 XAO:0004165 @@ -283067,11 +98544,11 @@ The modern definition of neurosecretion has evolved to include the release of an Few changes of evolutionary significance occur in the branching pattern of the dorsal aorta. All vertebrates have (...) paired intersegmental arteries to the trunk, tail, and paired appendages.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000225 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.612 - http://bgee.unil.ch/ @@ -283084,7 +98561,7 @@ The modern definition of neurosecretion has evolved to include the release of an intersegmental arteries ZFA:0001061 - + @@ -283117,15 +98594,16 @@ The modern definition of neurosecretion has evolved to include the release of an Arteries that supply the spinal cord. + + + EHDAA2:0001890 EHDAA:4355 EMAPA:18241 MA:0002043 NCIT:C33587 - SCTID:244228006 TAO:0000682 UMLS:C0447043 - Wikipedia:Spinal_artery ZFA:0000682 spinal arteries uberon @@ -283138,8 +98616,8 @@ The modern definition of neurosecretion has evolved to include the release of an Arteries that supply the spinal cord. - Wikipedia:Spinal_artery - https://orcid.org/0000-0002-6601-2165 + + @@ -283152,7 +98630,7 @@ The modern definition of neurosecretion has evolved to include the release of an spinal arteries ZFA:0000682 - + @@ -283179,6 +98657,8 @@ The modern definition of neurosecretion has evolved to include the release of an Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine. + + BTO:0000644 FMA:62974 GAID:1162 @@ -283186,7 +98666,6 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D007419 NCIT:C32875 UMLS:C0021849 - Wikipedia:Succus_entericus intestinal secretion succus entericus uberon @@ -283200,7 +98679,7 @@ The modern definition of neurosecretion has evolved to include the release of an Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine. - Wikipedia:Succus_entericus + @@ -283218,7 +98697,7 @@ The modern definition of neurosecretion has evolved to include the release of an succus entericus - Wikipedia:Succus_entericus + @@ -283244,6 +98723,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -283258,13 +98738,14 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a esophagus [Automatically generated definition]. UBERON:0003345 + + BTO:0002859 EMAPA:26981 FMA:62996 MA:0002680 MESH:D000071041 NCIT:C32538 - SCTID:362127004 UMLS:C0227176 esophageal mucosa esophageal mucous membrane @@ -283291,7 +98772,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a esophagus [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -283309,27 +98790,27 @@ The modern definition of neurosecretion has evolved to include the release of an esophagus mucous membrane - OBOL:automatic + OBOL:automatic lamina muscularis mucosae oesophageae FMA:62996 - FMA:TA + FMA:TA mucosa of esophagus - OBOL:automatic + OBOL:automatic mucosa of oesophagus - OBOL:automatic + OBOL:automatic @@ -283347,14 +98828,14 @@ The modern definition of neurosecretion has evolved to include the release of an oesophagus mucous membrane - OBOL:automatic + OBOL:automatic tunica mucosa oesophageae FMA:62996 - FMA:TA + FMA:TA @@ -283393,6 +98874,8 @@ The modern definition of neurosecretion has evolved to include the release of an Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts. see https://github.com/obophenotype/uberon/issues/27 Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.[VSAO] + + CALOHA:TS-2011 EMAPA:35179 FMA:224804 @@ -283401,7 +98884,6 @@ The modern definition of neurosecretion has evolved to include the release of an NCIT:C13076 UMLS:C0391978 VSAO:0000047 - Wikipedia:Bone_tissue XAO:0004040 ZFA:0005621 galen:BoneTissue @@ -283421,32 +98903,32 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO - https://github.com/obophenotype/uberon/issues/117 + Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts. - GO_REF:0000034 - PSPUB:0000170 + + GO_REF:0000034 + PSPUB:0000170 VSAO:0000047 - http://dx.plos.org/10.1371/journal.pone.0051070 Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000047 - VSAO + VSAO GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 - PSPUB:0000170 + PSPUB:0000170 @@ -283458,7 +98940,7 @@ The modern definition of neurosecretion has evolved to include the release of an osteogenic tissue - VSAO:curator + VSAO:curator @@ -283538,7 +99020,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -283549,7 +99031,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -283560,25 +99042,25 @@ The modern definition of neurosecretion has evolved to include the release of an - MP + MP An epithelium that is part of a iris [Automatically generated definition]. - OBOL:automatic + OBOL:automatic epithelial tissue of iris - OBOL:automatic + OBOL:automatic epithelium of iris - OBOL:automatic + OBOL:automatic @@ -283591,14 +99073,14 @@ The modern definition of neurosecretion has evolved to include the release of an epithelium pigmentosum iridis FMA:58517 - FMA:TA + FMA:TA iris epithelial tissue - OBOL:automatic + OBOL:automatic @@ -283621,127 +99103,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - - The supporting bundles of muscular fibers lining the walls of the ventricles of the heart. - The purpose of the trabeculae carneae is most likely to prevent suction that would occur with a flat surfaced membrane and thus impair the heart's ability to pump efficiently. The trabeculae carneae also serve a similar function to papillary muscles in that their contraction pulls on the chordae tendineae, preventing inversion of the mitral (bicuspid) and tricuspid valves, that is, their bulging towards the atrial chambers, which would lead to subsequent leakage of the blood into the atria. So by the action of papillary muscles on the atrioventricular valves, backflow of the blood from the ventricles into the atria is prevented - Note that WP states they are ventricular, but MP has classes for atrial ventricular carnea. - EMAPA:18626 - FMA:7269 - MA:0002831 - SCTID:118755002 - Wikipedia:Trabeculae_carneae - ventricle trabecula carnea - uberon - cardiac trabecula - columnae carneae - heart trabecula - trabecula of heart - trabeculae carneae - trabeculae carneae cordis - ventricular trabecula - UBERON:0002511 - - trabecula carnea - - - - - - - - - - - WP - - - - - The supporting bundles of muscular fibers lining the walls of the ventricles of the heart. - MGI:monikat - MP:0004067 - - - - - The purpose of the trabeculae carneae is most likely to prevent suction that would occur with a flat surfaced membrane and thus impair the heart's ability to pump efficiently. The trabeculae carneae also serve a similar function to papillary muscles in that their contraction pulls on the chordae tendineae, preventing inversion of the mitral (bicuspid) and tricuspid valves, that is, their bulging towards the atrial chambers, which would lead to subsequent leakage of the blood into the atria. So by the action of papillary muscles on the atrioventricular valves, backflow of the blood from the ventricles into the atria is prevented - WP - - - - - Note that WP states they are ventricular, but MP has classes for atrial ventricular carnea. - MP - - - - - ventricle trabecula carnea - MA:0002831 - - - - - cardiac trabecula - GO:0060347 - - - - - columnae carneae - Wikipedia:Trabeculae_carneae - - - - - - heart trabecula - GO:0060347 - - - - - trabeculae carneae - - - - - - trabeculae carneae cordis - Wikipedia:Trabeculae_carneae - - - - - - ventricular trabecula - MA:0002831 - - - - @@ -283801,13 +99162,13 @@ The modern definition of neurosecretion has evolved to include the release of an endochondral bone https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern - http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg + http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg - VSAO + VSAO @@ -283818,27 +99179,27 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO Replacement bone that forms within cartilage. + + GO:0001958 - GO_REF:0000034 + GO_REF:0000034 VSAO:0000145 - http://dx.plos.org/10.1371/journal.pone.0051070 - https://github.com/obophenotype/uberon/issues/54 Replacement bone that forms within cartilage.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000145 - VSAO + VSAO GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 - PSPUB:0000170 + PSPUB:0000170 @@ -283863,7 +99224,7 @@ The modern definition of neurosecretion has evolved to include the release of an endochondral bones ZFA:0001591 - + @@ -283887,9 +99248,9 @@ The modern definition of neurosecretion has evolved to include the release of an Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]. Bone that forms directly within mesenchyme, and does not replace other tissues.[TAO] [In TAO], This term was made obsolete because it is considered a synonym of membrane bone (VSAO:0000023).[TAO] + EMAPA:36615 TAO:0001644 - Wikipedia:Intramembranous_ossification ZFA:0001635 uberon intramembranous bones @@ -283901,40 +99262,40 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]. + + GO:0001957 - Wikipedia:Intramembranous_ossification - https://github.com/obophenotype/uberon/issues/267 Bone that forms directly within mesenchyme, and does not replace other tissues.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001644 - TAO - TAO:wd + TAO + TAO:wd [In TAO], This term was made obsolete because it is considered a synonym of membrane bone (VSAO:0000023).[TAO] - 2012-09-06 + 2012-09-06 TAO:0001644 - TAO - Curator + TAO + Curator intramembranous bones ZFA:0001635 - + @@ -283949,6 +99310,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -283969,14 +99331,15 @@ The modern definition of neurosecretion has evolved to include the release of an The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof. basicranial + + + FMA:52801 MA:0002840 MESH:D019291 MFMO:0000044 NCIT:C12493 - SCTID:181890004 UMLS:C0149543 - Wikipedia:Base_of_skull base of cranium base of skull basis cranii @@ -283987,13 +99350,13 @@ The modern definition of neurosecretion has evolved to include the release of an The skull base is formed from a series of cartilages either side of, and rostral to, the notochord, whose tip lies just caudal to the pituitary gland. It is closely associated with the sensory capsules, which partially or completely sur- round the olfactory epithelium, the eye, and the inner ear[PMID:11523816] basicranium - http://upload.wikimedia.org/wikipedia/commons/8/81/Gray193.png + http://upload.wikimedia.org/wikipedia/commons/8/81/Gray193.png The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof. - Wikipedia:Base_of_skull + @@ -284011,9 +99374,9 @@ The modern definition of neurosecretion has evolved to include the release of an basis cranii + FMA:52801 - FMA:TA - Wikipedia:Base_of_skull + FMA:TA @@ -284054,13 +99417,13 @@ The modern definition of neurosecretion has evolved to include the release of an Connective tissue composed of elastic fibers. + + FMA:20113 GAID:926 MA:0002853 MESH:D004547 NCIT:C32495 - SCTID:27197004 - Wikipedia:Elastic_fiber elastic connective tissue textus connectivus elasticus elastic fiber @@ -284068,13 +99431,13 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0002521 elastic tissue - http://upload.wikimedia.org/wikipedia/commons/c/cb/Gray377.png + http://upload.wikimedia.org/wikipedia/commons/c/cb/Gray377.png Connective tissue composed of elastic fibers. - http://orcid.org/0000-0002-6601-2165 + @@ -284108,6 +99471,9 @@ The modern definition of neurosecretion has evolved to include the release of an The middle layer of an artery or vein. [WP,unvetted]. + + + BTO:0002011 EMAPA:36298 FMA:55590 @@ -284115,22 +99481,20 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002855 MESH:D017540 NCIT:C33821 - SCTID:61695000 UMLS:C0162867 - Wikipedia:Tunica_media uberon tunica media vasorum UBERON:0002522 May be composed of smooth muscle and elastic tissue tunica media - https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg + https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg - MA + MA @@ -284141,7 +99505,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -284152,13 +99516,13 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm The middle layer of an artery or vein. [WP,unvetted]. - Wikipedia:Tunica_media + @@ -284170,17 +99534,22 @@ The modern definition of neurosecretion has evolved to include the release of an tunica media vasorum - BTO:0002011 - Wikipedia:Tunica_media + + + + + tunica media vasorum + BTO:0002011 + - + @@ -284204,6 +99573,10 @@ The modern definition of neurosecretion has evolved to include the release of an the FMA class represents a more generic layer which is the superclass of the layer found in both blood vessels and lymph vessels (and also endocardium) - we should probably follow this structure the FMA class represents a structure which may have both epithelium and fibroelastic connective tissue as parts The tunica intima (or just intima) is the innermost layer of an artery or vein. It is made up of one layer of endothelial cells and is supported by an internal elastic lamina. The endothelial cells are in direct contact with the blood flow. The inner coat (tunica intima) can be separated from the middle by a little maceration, or it may be stripped off in small pieces; but, on account of its friability, it cannot be separated as a complete membrane. It is a fine, transparent, colorless structure which is highly elastic, and, after death, is commonly corrugated into longitudinal wrinkles. The inner coat consists of: A layer of pavement endothelium, the cells of which are polygonal, oval, or fusiform, and have very distinct round or oval nuclei. This endothelium is brought into view most distinctly by staining with silver nitrate. A subendothelial layer, consisting of delicate connective tissue with branched cells lying in the interspaces of the tissue; in arteries of less than 2 mm. in diameter the subendothelial layer consists of a single stratum of stellate cells, and the connective tissue is only largely developed in vessels of a considerable size. An elastic or fenestrated layer, which consists of a membrane containing a net-work of elastic fibers, having principally a longitudinal direction, and in which, under the microscope, small elongated apertures or perforations may be seen, giving it a fenestrated appearance. It was therefore called by Henle the fenestrated membrane. This membrane forms the chief thickness of the inner coat, and can be separated into several layers, some of which present the appearance of a network of longitudinal elastic fibers, and others a more membranous character, marked by pale lines having a longitudinal direction. In minute arteries the fenestrated membrane is a very thin layer; but in the larger arteries, and especially in the aorta, it has a very considerable thickness. [WP,unvetted].[Wikipedia] + + + + BTO:0002012 EMAPA:36297 FMA:55589 @@ -284211,10 +99584,7 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002861 MESH:D017539 NCIT:C33820 - SCTID:8361002 - SCTID:87483006 UMLS:C0162864 - Wikipedia:Tunica_intima uberon Bichat's tunic intima @@ -284222,13 +99592,13 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0002523 tunica intima - https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg + https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg - FMA + FMA @@ -284250,22 +99620,22 @@ The modern definition of neurosecretion has evolved to include the release of an - ISBN:0073040584 + ISBN:0073040584 The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]. - ISBN:0073040584 + + ISBN:0073040584 NCIT:C33820 - Wikipedia:Tunica_intima The tunica intima (or just intima) is the innermost layer of an artery or vein. It is made up of one layer of endothelial cells and is supported by an internal elastic lamina. The endothelial cells are in direct contact with the blood flow. The inner coat (tunica intima) can be separated from the middle by a little maceration, or it may be stripped off in small pieces; but, on account of its friability, it cannot be separated as a complete membrane. It is a fine, transparent, colorless structure which is highly elastic, and, after death, is commonly corrugated into longitudinal wrinkles. The inner coat consists of: A layer of pavement endothelium, the cells of which are polygonal, oval, or fusiform, and have very distinct round or oval nuclei. This endothelium is brought into view most distinctly by staining with silver nitrate. A subendothelial layer, consisting of delicate connective tissue with branched cells lying in the interspaces of the tissue; in arteries of less than 2 mm. in diameter the subendothelial layer consists of a single stratum of stellate cells, and the connective tissue is only largely developed in vessels of a considerable size. An elastic or fenestrated layer, which consists of a membrane containing a net-work of elastic fibers, having principally a longitudinal direction, and in which, under the microscope, small elongated apertures or perforations may be seen, giving it a fenestrated appearance. It was therefore called by Henle the fenestrated membrane. This membrane forms the chief thickness of the inner coat, and can be separated into several layers, some of which present the appearance of a network of longitudinal elastic fibers, and others a more membranous character, marked by pale lines having a longitudinal direction. In minute arteries the fenestrated membrane is a very thin layer; but in the larger arteries, and especially in the aorta, it has a very considerable thickness. [WP,unvetted].[Wikipedia] Wikipedia - Wikipedia:Tunica_intima + @@ -284319,6 +99689,9 @@ The modern definition of neurosecretion has evolved to include the release of an An organ that functions as a secretory or excretory organ. glandular + + + AAO:0000212 AEO:0000096 BTO:0000522 @@ -284336,9 +99709,8 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000021 MIAA:0000021 NCIT:C13319 - SCTID:134358001 + OpenCyc:Mx4rwP3vyJwpEbGdrcN5Y29ycA UMLS:C1285092 - Wikipedia:Gland WikipediaCategory:Glands galen:Gland glandular organ @@ -284350,13 +99722,13 @@ The modern definition of neurosecretion has evolved to include the release of an gland - http://upload.wikimedia.org/wikipedia/commons/a/a1/Gray1026.png + http://upload.wikimedia.org/wikipedia/commons/a/a1/Gray1026.png An organ that functions as a secretory or excretory organ. - MGI:csmith + MGI:csmith MP:0002163 @@ -284369,7 +99741,7 @@ The modern definition of neurosecretion has evolved to include the release of an glandular organ - http://orcid.org/0000-0002-6601-2165 + @@ -284381,10 +99753,15 @@ The modern definition of neurosecretion has evolved to include the release of an glandula - BTO:0000522 - Wikipedia:Gland + + + + + glandula + BTO:0000522 + @@ -284401,12 +99778,12 @@ The modern definition of neurosecretion has evolved to include the release of an In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]. MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG] + BTO:0004593 FMA:296704 MAT:0000067 MIAA:0000067 VHOG:0000243 - Wikipedia:Epiblast epiblast uberon blastocyst @@ -284419,24 +99796,24 @@ The modern definition of neurosecretion has evolved to include the release of an epiblast (generic) - http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png + http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]. - Wikipedia:Epiblast - ZFIN:curator + + ZFIN:curator In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000243 - VHOG + VHOG + DOI:10.1146/annurev.cellbio.042308.113344 Zorn AM, Wells JM, Vertebrate endoderm development and organ formation. Annual Review of Cell Developmental Biology (2009) - http://bgee.unil.ch/ @@ -284454,7 +99831,7 @@ The modern definition of neurosecretion has evolved to include the release of an epiblastus - Wikipedia:Epiblast + @@ -284469,7 +99846,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -284482,6 +99859,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node. See notes from https://github.com/obophenotype/uberon/wiki/The-neural-crest Rapidly proliferating mass of cells at the caudal extremity of the embryo. Its formation is reflected in a caudal carving of the posterior portion of the archenteric canal at NF stage 22. With its further outgrowth, the postanal gut primordium becomes stretched. Its lumen is in broad communication with the hindgut at NF stage 25.[AAO] @@ -284520,9 +99903,9 @@ The modern definition of neurosecretion has evolved to include the release of an Rapidly proliferating mass of cells at the caudal extremity of the embryo. Its formation is reflected in a caudal carving of the posterior portion of the archenteric canal at NF stage 22. With its further outgrowth, the postanal gut primordium becomes stretched. Its lumen is in broad communication with the hindgut at NF stage 25.[AAO] - 2012-06-20 + 2012-06-20 AAO:0011104 - AAO + AAO ISBN:0815318960 OMD:tail+bud @@ -284530,11 +99913,11 @@ The modern definition of neurosecretion has evolved to include the release of an (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (5) a larva or embryo with a postanal tail.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000201 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 - http://bgee.unil.ch/ @@ -284561,6 +99944,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -284575,6 +99959,7 @@ The modern definition of neurosecretion has evolved to include the release of an Sense organ embedded in the integument and consisting of one or a cluster of sensory neurons and associated sensory structures, support cells and glial cells forming a single organised unit with a largely bona-fide boundary.[FBbt]. this term should be ceded to the arthropod anatomy ontology + BTO:0001237 EFO:0000939 FBbt:00007152 @@ -284582,7 +99967,6 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000163 MIAA:0000163 TGMA:0000540 - Wikipedia:Sensillum sensillum uberon UBERON:0002536 @@ -284594,8 +99978,8 @@ The modern definition of neurosecretion has evolved to include the release of an Sense organ embedded in the integument and consisting of one or a cluster of sensory neurons and associated sensory structures, support cells and glial cells forming a single organised unit with a largely bona-fide boundary.[FBbt]. + FBbt:00007152 - Wikipedia:Sensillum @@ -284653,6 +100037,9 @@ The modern definition of neurosecretion has evolved to include the release of an One of a series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO] A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down.[well established][VHOG] Numbered cranial to caudal. different in mammals. branchial arch = ZFA:0001613 pharyngeal arch 3-7. generally gill arch 1 = pharyngeal arch 3. terminology varies as to whether branchial arch follows gill or pharyngeal numbering + + + AAO:0010359 BTO:0001785 EFO:0000959 @@ -284664,11 +100051,9 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D001934 MIAA:0000242 NCIT:C34249 - SCTID:308766004 TAO:0001306 UMLS:C0080322 VHOG:0000155 - Wikipedia:Pharyngeal_arch XAO:0000096 ZFA:0001306 pharyngeal arches @@ -284682,13 +100067,13 @@ The modern definition of neurosecretion has evolved to include the release of an pharyngeal arch - http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray41.png + http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray41.png - EHDAA2 + EHDAA2 @@ -284699,7 +100084,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:16313389 + @@ -284710,7 +100095,7 @@ The modern definition of neurosecretion has evolved to include the release of an - http://tolweb.org/Chordata/2499 + @@ -284721,7 +100106,7 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/The-neural-crest + @@ -284732,34 +100117,34 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:16313389 + One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches. - PMID:16313389 + + ZFA:yb - http://orcid.org/0000-0002-6601-2165 One of a series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010359 - AAO + AAO NLM:branchial+arch A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000155 - VHOG + VHOG + DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) - http://bgee.unil.ch/ @@ -284771,7 +100156,7 @@ The modern definition of neurosecretion has evolved to include the release of an pharyngeal arches - + @@ -284784,7 +100169,7 @@ The modern definition of neurosecretion has evolved to include the release of an arcus pharyngei - Wikipedia:Pharyngeal_arch + @@ -284829,7 +100214,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -284840,51 +100225,51 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:11523831 - PMID:22512454 + + Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic. - http://www.ncbi.nlm.nih.gov/books/NBK53175/ - https://github.com/obophenotype/uberon/issues/135 - https://github.com/seger/aao/issues/4 - https://orcid.org/0000-0002-6601-2165 - https://sourceforge.net/p/obo/xenopus-anatomy-xao-term-requests/11/ + + + + + Comparisons of developmental gene expression suggest that the anterior ectoderm in amphioxus may be homologous to the vertebrate olfactory placode, the only vertebrate placode with primary, not secondary, neurons - PMID:11523831 + ectodermal placode + FMA:293966 - PMID:22512454 placode - Wikipedia:Placode + ectodermal cranial placode - UBERON:cjm + UBERON:cjm cranial placodes XAO:0000305 - + @@ -284920,13 +100305,14 @@ The modern definition of neurosecretion has evolved to include the release of an TODO discriminate between stages and organisms Whole organism that is premetamorphic or a very immature individual.[TAO] larval + AEO:0000126 BTO:0000707 FBbt:00001727 HAO:0000459 MESH:D007814 + OpenCyc:Mx4rwQCBvZwpEbGdrcN5Y29ycA TAO:0002048 - Wikipedia:Larva larval organism ammocoete bipinnaria @@ -284952,16 +100338,16 @@ The modern definition of neurosecretion has evolved to include the release of an A distinct juvenile form many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle. - Wikipedia:Larva + Whole organism that is premetamorphic or a very immature individual.[TAO] - 2012-08-14 + 2012-08-14 TAO:0002048 - TAO - TAO:wd + TAO + TAO:wd @@ -284973,91 +100359,91 @@ The modern definition of neurosecretion has evolved to include the release of an ammocoete - Wikipedia:Larva + bipinnaria - Wikipedia:Larva + caterpillar - Wikipedia:Larva + glochidium - Wikipedia:Larva + grub - Wikipedia:Larva + leptocephalus - Wikipedia:Larva + maggot - Wikipedia:Larva + naiad - Wikipedia:Larva + nymph - Wikipedia:Larva + planula - Wikipedia:Larva + tadpole - Wikipedia:Larva + trochophore - Wikipedia:Larva + veliger - Wikipedia:Larva + wriggler - Wikipedia:Larva + zoea - Wikipedia:Larva + @@ -285095,7 +100481,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37442 - MA:th + MA:th @@ -285104,9 +100490,9 @@ The modern definition of neurosecretion has evolved to include the release of an + BIRNLEX:1019 FMA:12237 - SCTID:362606005 cavity of organ uberon UBERON:0002558 @@ -285136,6 +100522,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -285165,13 +100552,13 @@ The modern definition of neurosecretion has evolved to include the release of an The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube. - https://orcid.org/0000-0002-6601-2165 + - DOI:10.1186/s12983-014-0089-2 + @@ -285223,10 +100610,11 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia. + + BIRNLEX:1167 FMA:55676 NCIT:C13031 - SCTID:384763002 UMLS:C0445620 anatomical structure of brain biological structure of brain @@ -285257,25 +100645,25 @@ The modern definition of neurosecretion has evolved to include the release of an anatomical structure of brain - OBOL:automatic + OBOL:automatic biological structure of brain - OBOL:automatic + OBOL:automatic brain anatomical structure - OBOL:automatic + OBOL:automatic brain biological structure - OBOL:automatic + OBOL:automatic @@ -285320,12 +100708,13 @@ The modern definition of neurosecretion has evolved to include the release of an A spinal cord segment that adjacent_to a cervical region. - + + + BIRNLEX:1499 FMA:71166 MA:0003081 NCIT:C12892 - SCTID:180960003 UMLS:C0581619 UMLS:C1278837 neuronames:1654 @@ -285336,20 +100725,24 @@ The modern definition of neurosecretion has evolved to include the release of an segmenta cervicalia medullae spinalis [1-8 uberon UBERON:0002726 - cervical spinal cord A spinal cord segment that adjacent_to a cervical region. - OBOL:automatic + OBOL:automatic UMLS:C0581619 BIRNLEX:1499 + + + + + UMLS:C0581619 ncithesaurus:Cervical_Spinal_Cord @@ -285381,7 +100774,7 @@ The modern definition of neurosecretion has evolved to include the release of an pars cervicalis medullae spinalis FMA:71166 - FMA:TA + FMA:TA @@ -285389,7 +100782,7 @@ The modern definition of neurosecretion has evolved to include the release of an segmenta cervicalia medullae spinalis [1-8 FMA:71166 - FMA:TA + FMA:TA @@ -285425,6 +100818,9 @@ The modern definition of neurosecretion has evolved to include the release of an A nucleus of brain that is part of a trigeminal nuclear complex. massive inconsistencies between GO, MA, wikipedia. Part of pons in MA, but this leads to inconsistencies with ABA. + + + BM:V BTO:0001074 CALOHA:TS-2077 @@ -285435,10 +100831,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001028 MESH:D014278 NCIT:C12807 - SCTID:280164007 UMLS:C0040999 VHOG:0001353 - http://uri.neuinfo.org/nif/nifstd/nifext_11 nucleus of trigeminal nuclear complex trigeminal V nucleus trigeminal nuclear complex nucleus @@ -285455,13 +100849,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A nucleus of brain that is part of a trigeminal nuclear complex. - OBOL:automatic + OBOL:automatic @@ -285526,6 +100920,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -285559,15 +100954,16 @@ The modern definition of neurosecretion has evolved to include the release of an Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133). involved in the initiation of REM sleep [Wikipedia:Pontine_tegmentum] + + + BAMS:PTg BIRNLEX:923 DHBA:12416 FMA:71108 HBA:9135 MESH:D065821 - SCTID:362401009 UMLS:C0228426 - Wikipedia:Pontine_tegmentum neuronames:557 dorsal pons dorsal portion of pons @@ -285582,9 +100978,7 @@ The modern definition of neurosecretion has evolved to include the release of an pontine tegmentum - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb - https://upload.wikimedia.org/wikipedia/commons/9/9c/Brainstem_Abducens.png + https://upload.wikimedia.org/wikipedia/commons/9/9c/Brainstem_Abducens.png @@ -285627,7 +101021,7 @@ The modern definition of neurosecretion has evolved to include the release of an tegmentum pontis FMA:71108 - FMA:TA + FMA:TA @@ -285648,7 +101042,7 @@ The modern definition of neurosecretion has evolved to include the release of an tegmentum pontis - Wikipedia:Pontine_tegmentum + @@ -285666,9 +101060,10 @@ The modern definition of neurosecretion has evolved to include the release of an A wall, dividing a cavity or structure into smaller ones[WP]. septal + AAO:0011127 FMA:86461 - Wikipedia:Septum + OpenCyc:Mx4rrqot_on_EdaAAAACs0uFOQ septa uberon UBERON:0003037 @@ -285680,13 +101075,13 @@ The modern definition of neurosecretion has evolved to include the release of an A wall, dividing a cavity or structure into smaller ones[WP]. - Wikipedia:Septum + septa - + @@ -285719,14 +101114,14 @@ The modern definition of neurosecretion has evolved to include the release of an The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted]. - + + + BIRNLEX:966 FMA:71167 MA:0003082 NCIT:C12894 - SCTID:278750009 UMLS:C0581620 - Wikipedia:Thoracic_spinal_cord neuronames:1718 pars thoracica medullae spinalis segmenta thoracica medullae spinalis [1-12] @@ -285736,22 +101131,26 @@ The modern definition of neurosecretion has evolved to include the release of an thoracic spinal cord uberon UBERON:0003038 - thoracic spinal cord - http://upload.wikimedia.org/wikipedia/commons/6/68/Gray820.png + http://upload.wikimedia.org/wikipedia/commons/6/68/Gray820.png The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted]. - Wikipedia:Thoracic_spinal_cord + UMLS:C0581620 BIRNLEX:966 + + + + + UMLS:C0581620 ncithesaurus:Thoracic_Spinal_Cord @@ -285759,7 +101158,7 @@ The modern definition of neurosecretion has evolved to include the release of an pars thoracica medullae spinalis FMA:71167 - FMA:TA + FMA:TA @@ -285767,7 +101166,7 @@ The modern definition of neurosecretion has evolved to include the release of an segmenta thoracica medullae spinalis [1-12] FMA:71167 - FMA:TA + FMA:TA @@ -285881,7 +101280,7 @@ The modern definition of neurosecretion has evolved to include the release of an ZFA - https://sourceforge.net/p/obo/zebrafish-anatomy-zfa-term-requests/106/ + @@ -285915,11 +101314,11 @@ The modern definition of neurosecretion has evolved to include the release of an Lampreys also have an MHB [midbrain hindbrain boundary], expressing a similar repertoire of regulatory gene cognates as in gnathostomes.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000649 - VHOG + VHOG + DOI:10.1016/j.ydbio.2005.02.008 Murakami Y, Uchida K, Rijli FM and Kuratani S, Evolution of the brain developmental plan: Insights from agnathans. Developmental Biology (2005) - http://bgee.unil.ch/ @@ -285938,7 +101337,7 @@ The modern definition of neurosecretion has evolved to include the release of an isthmus/MHB Geisha:syn - NCBITaxon:8782 + NCBITaxon:8782 @@ -285972,7 +101371,7 @@ The modern definition of neurosecretion has evolved to include the release of an In mice, the first non-basal layer formed at ~E9.5; it is a temporary structure composed of simple squamous epithelium that serves as the first barrier to the embryo's physical environment, exists throughout the entire keratinocyte stratification process, and sheds off at ~E17, when it is replaced by corneocytes[MP] In some mammals, Eyelid Fusion is thought to be driven by a population of cells which are derived from the periderm, the outermost layer of the developing epidermis Originally the epidermis is one layer thick, in most vertebrates it soon becomes a two-layered structure. The outer layer gives rise to the periderm. The periderm goes through distinct developmental phases and is ultimately sloughed into the amniotic fluid when differentiation of the underlying epidermal layers is complete. The function of the periderm is not known, but is thought to be related to transport/exchange between the fetus and the amniotic fluid (http://courses.washington.edu/hubio567/devbio/periderm.html) - BTO:0003377 + EHDAA2:0001846 EHDAA:6538 FMA:295662 @@ -285998,7 +101397,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -286009,7 +101408,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -286020,7 +101419,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -286031,7 +101430,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -286043,24 +101442,18 @@ The modern definition of neurosecretion has evolved to include the release of an The outermost epidermal layer covering the fish at embryonic stages; derived from the EVL and thought to eventually be replaced by the superficial stratum of the epidermis. Sometimes used synonymously with EVL. Le Guellec et al, 2004.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001185 - TAO - ZFIN:curator + TAO + ZFIN:curator relationship type change: OBO_REL:part_of ectoderm (TAO:0000016) CHANGED TO: develops_from ectoderm (UBERON:0000924)[TAO] - 2012-08-14 + 2012-08-14 TAO:0001185 - TAO - - - - - BTO:0003377 - https://orcid.org/0000-0003-4423-4370 + TAO @@ -286128,11 +101521,11 @@ The modern definition of neurosecretion has evolved to include the release of an (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001200 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 - http://bgee.unil.ch/ @@ -286140,6 +101533,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -286174,11 +101568,11 @@ The modern definition of neurosecretion has evolved to include the release of an (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001201 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 - http://bgee.unil.ch/ @@ -286259,38 +101653,38 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. - ZFIN:curator + ZFIN:curator Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000279 - TAO - ZFIN:curator + TAO + ZFIN:curator It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000559 - VHOG + VHOG + DOI:10.1006/dbio.2001.0460 Schubert M, Holland LZ, Dale Stokes M and Holland ND, Three Amphoxius Wnt Genes (AmphiWnt3, AmphiWnt5, and AmphiWnt6) Associated with the Tail Bud: the Evolution of Somitogenesis in Chordates. Developmental Biology (2001) - http://bgee.unil.ch/ unsegmented paraxial mesoderm - https://orcid.org/0000-0002-6601-2165 + @@ -286317,6 +101711,18 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + @@ -286336,6 +101742,8 @@ The modern definition of neurosecretion has evolved to include the release of an Small clusters of mesodermal cells called blood islands mark the embryonic debut of the cardiovascular system (in vertebrates) (reference 1); In birds and mammals, primitive hemangioblasts are extraembryonic, populating the yolk sac as the so-called blood islands (reference 2).[well established][VHOG] EHDAA2 distinguishes 3 types, but does not have a superclass. The VHOG class may refer to yolk sac ventral lateral plate mesoderm + + AAO:0011006 EFO:0003489 EHDAA:207 @@ -286344,7 +101752,6 @@ The modern definition of neurosecretion has evolved to include the release of an TE:E5.11.2.0.0.0.4 UMLS:C1511224 VHOG:0000085 - Wikipedia:Blood_island_of_umbilical_vesicle XAO:0000067 ZFA:0000094 blood islands @@ -286361,53 +101768,75 @@ The modern definition of neurosecretion has evolved to include the release of an blood island + + + + + + + + + + ISBN:0073040584 + + + + + + + + + + + ISBN:0073040584 + Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]. - Wikipedia:Blood_island_of_umbilical_vesicle + Nests of developing blood cells arising late in the segmentation period from the intermediate mass, and located in the anterior-ventral tail, just posterior to the yolk extension. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000094 - TAO - ZFIN:curator + TAO + ZFIN:curator Region located on the ventral surface of the developing embryo that is a site of hematopoiesis and that is analogous to the yolk sac blood islands of higher vertebrates.[AAO] - 2012-06-20 + 2012-06-20 AAO:0011006 - AAO - AAO:EJS + AAO + AAO:EJS relationship loss: part_of intermediate cell mass of mesoderm (TAO:0000033)[TAO] - 2012-08-14 + 2012-08-14 TAO:0000094 - TAO + TAO Small clusters of mesodermal cells called blood islands mark the embryonic debut of the cardiovascular system (in vertebrates) (reference 1); In birds and mammals, primitive hemangioblasts are extraembryonic, populating the yolk sac as the so-called blood islands (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000085 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.450, DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood cells and blood cell development in the animal kingdom. Annual Review of Cell and Developmental Biology (2006) - http://bgee.unil.ch/ EHDAA2 distinguishes 3 types, but does not have a superclass. The VHOG class may refer to yolk sac - EHDAA2 + EHDAA2 @@ -286419,7 +101848,7 @@ The modern definition of neurosecretion has evolved to include the release of an blood islands - + @@ -286427,6 +101856,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -286454,13 +101884,13 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0004881 head mesenchyme head mesoderm + AAO:0011085 EHDAA2:0001493 EHDAA:181 FMA:295532 TAO:0000060 VHOG:0000086 - Wikipedia:Prechordal_plate XAO:0000079 ZFA:0000060 uberon @@ -286479,7 +101909,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -286503,29 +101933,29 @@ The modern definition of neurosecretion has evolved to include the release of an Axial hypoblast located anterior to the chorda mesoderm; the polster is its most anterior region. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000060 - TAO - ZFIN:curator + TAO + ZFIN:curator Axial mesoderm that lies anterior to the notochord and that underlies the forebrain. [Amphioxus_goosecoid_and_the_evolution_of_the_head_organizer_and_prechordal_plate._Evolution_and_Development_(2008)_2(6):303-310, Neidert_AH, Panopoulou_G_and_Langeland_JA][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000086 - VHOG - http://bgee.unil.ch/ + VHOG + There are two opposing models that can potentially explain the differences in gsc (goosecoid) expression between amphioxus and vertebrates. In one model, the vertebrate gsc expression pattern more closely resembles the common ancestral state and the amphioxus gsc expression pattern is a derivation associated with its unique morphology. (...) In an alternate model, the amphioxus gsc expression pattern most closely represents the common ancestral state and the vertebrate pattern is derived. This model suggests that the evolution of vertebrates was accompanied by the segregation of gsc expression, from a more general domain underlying the entire brain anlage to a distinct forebrain organizer domain and subsequent prechordal plate. We feel this second model is more parsimonious than the first model in that what would be novel anterior gsc expression in vertebrates directly correlates with a novel vertebrate anterior structure, the prechordal plate.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000086 - VHOG + VHOG + DOI:10.1046/j.1525-142x.2000.00073.x Neidert AH, Panopoulou G and Langeland JA, Amphioxus goosecoid and the evolution of the head organizer and prechordal plate. Evolution and Development (2008) - http://bgee.unil.ch/ @@ -286545,6 +101975,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -286586,16 +102017,17 @@ The modern definition of neurosecretion has evolved to include the release of an Mesoderm between somite and lateral plate. Traditionally thought to give rise to the urogenital system.[AAO] (...)the mesoderm of a developing vertebrate transitionally differentiates into the following sub-types: Chordamesoderm (also known as axial mesoderm) which later on gives rise to notochord in all chordates, Paraxial mesoderm, Intermediate mesoderm, Lateral plate mesoderm (reference 1); The mesoderm is present in Bilateria, therefore they are sometimes called triploblasts. Ectoderm and endoderm are usually organized as epithelial layers, while mesoderm can be epithelial or a compact, three-dimensional tissue.[well established][VHOG] all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). + + + AAO:0010575 EMAPA:16056 EMAPA:16178 FMA:293147 NCIT:C34193 - SCTID:361476001 TAO:0001206 UMLS:C1284010 VHOG:0000087 - Wikipedia:Intermediate_mesoderm XAO:0000085 ZFA:0001206 uberon @@ -286609,7 +102041,7 @@ The modern definition of neurosecretion has evolved to include the release of an intermediate mesoderm - http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png + http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png @@ -286620,7 +102052,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AAO + AAO @@ -286631,7 +102063,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EMAPA + EMAPA @@ -286642,33 +102074,33 @@ The modern definition of neurosecretion has evolved to include the release of an - XAO + XAO The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. + GOC:curators - Wikipedia:Intermediate_mesoderm Mesoderm between somite and lateral plate. Traditionally thought to give rise to the urogenital system.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010575 - AAO - AAO:EJS + AAO + AAO:EJS (...)the mesoderm of a developing vertebrate transitionally differentiates into the following sub-types: Chordamesoderm (also known as axial mesoderm) which later on gives rise to notochord in all chordates, Paraxial mesoderm, Intermediate mesoderm, Lateral plate mesoderm (reference 1); The mesoderm is present in Bilateria, therefore they are sometimes called triploblasts. Ectoderm and endoderm are usually organized as epithelial layers, while mesoderm can be epithelial or a compact, three-dimensional tissue.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000087 - VHOG + VHOG + Wikipedia:Mesoderm, ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.43 - http://bgee.unil.ch/ @@ -286686,7 +102118,7 @@ The modern definition of neurosecretion has evolved to include the release of an intermediate mesenchyme - https://github.com/obophenotype/uberon/wiki/The-neural-crest + @@ -286698,13 +102130,13 @@ The modern definition of neurosecretion has evolved to include the release of an intermediate plate mesoderm - https://orcid.org/0000-0002-6601-2165 + mesenchyma intermedium - Wikipedia:Intermediate_mesoderm + @@ -286742,24 +102174,24 @@ The modern definition of neurosecretion has evolved to include the release of an Lateral neurogenic placodes positioned dorsal of the epibranchial placodes. - ZFIN:curator + ZFIN:curator In summary, the collective term 'placodes' refers to some rather different structures, probably with different evolutionary origins. Some sensory placodes (at least the otic and olfactory) may have homologues in basal chordates. Even if this is so, it is apparent that they were elaborated considerably during early vertebrate evolution. Epibranchial and dorsolateral placodes appear to be new; we infer that their origin depended on the evolution of specific inductive signals.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000103 - VHOG + VHOG + DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000) - http://bgee.unil.ch/ dorsolateral placodes ZFA:0001310 - + @@ -286767,6 +102199,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -286794,11 +102227,11 @@ The modern definition of neurosecretion has evolved to include the release of an The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG] + AAO:0011017 EFO:0003647 TAO:0001204 VHOG:0000107 - Wikipedia:Chordamesoderm XAO:0000205 ZFA:0001204 uberon @@ -286807,29 +102240,29 @@ The modern definition of neurosecretion has evolved to include the release of an axial mesoderm - http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png + http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. + GO:0048318 - Wikipedia:Chordamesoderm The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000107 - VHOG - http://bgee.unil.ch/ + VHOG + chordamesoderm - Wikipedia:Chordamesoderm + @@ -286872,15 +102305,15 @@ The modern definition of neurosecretion has evolved to include the release of an - ISBN:0471888893 + ISBN:0471888893 A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion. - PMID:22512454 - http://orcid.org/0000-0002-6601-2165 - https://github.com/obophenotype/uberon/issues/693 + + + @@ -286892,20 +102325,20 @@ The modern definition of neurosecretion has evolved to include the release of an The ectodermal rudiment of the trigeminal ganglion, distinguishable during much of the segmentation period. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000162 - TAO - ZFIN:curator + TAO + ZFIN:curator The dorsolateral placodes (trigeminal and vestibular) develop from ectoderm lateral to the brain (...). In summary, the collective term 'placodes' refers to some rather different structures, probably with different evolutionary origins. Some sensory placodes (at least the otic and olfactory) may have homologues in basal chordates. Even if this is so, it is apparent that they were elaborated considerably during early vertebrate evolution. Epibranchial and dorsolateral placodes appear to be new; we infer that their origin depended on the evolution of specific inductive signals.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000109 - VHOG + VHOG + DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000) - http://bgee.unil.ch/ @@ -286920,14 +102353,14 @@ The modern definition of neurosecretion has evolved to include the release of an profundus V placode - ISBN:0471888893 + ISBN:0471888893 profundus placode - ISBN:0471888893 + ISBN:0471888893 @@ -286935,7 +102368,7 @@ The modern definition of neurosecretion has evolved to include the release of an trigeminal placodes ZFA:0000162 - + @@ -287006,7 +102439,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -287017,8 +102450,8 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:16496288 - XAO + + XAO @@ -287037,7 +102470,7 @@ The modern definition of neurosecretion has evolved to include the release of an eye placode - OBOL:automatic + OBOL:automatic @@ -287049,8 +102482,8 @@ The modern definition of neurosecretion has evolved to include the release of an optic placode of camera-type eye + GO:0046619 - https://orcid.org/0000-0002-6601-2165 @@ -287062,7 +102495,7 @@ The modern definition of neurosecretion has evolved to include the release of an optic placodes - + @@ -287098,12 +102531,13 @@ The modern definition of neurosecretion has evolved to include the release of an Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]. (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup.[well established][VHOG] + + BTO:0005351 EHDAA2:0001303 EHDAA:2912 EMAPA:16674 NCIT:C34233 - SCTID:308789007 TAO:0001202 UMLS:C0231109 VHOG:0000167 @@ -287127,7 +102561,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -287138,25 +102572,25 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]. + MP:0004269 - Wikipedia:Optic_cup_(embryology) ZFA:0001202 (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000167 - VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 - http://bgee.unil.ch/ + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 @@ -287225,6 +102659,8 @@ The modern definition of neurosecretion has evolved to include the release of an Ectodermal primordium of the lens of the eye. Kimmel et al, 1995.[TAO] (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG] Classical transplantation experiments using amphibian embryos suggested that the optic vesicle is the source of lens-inducing signals sufficient to generate lens tissues in competent ectoderm (reviewed in Grainger et al., 1996). More recent findings suggest a multistep model for lens induction. There is now good evidence that lens specification occurs at the neurula stage, before the optic vesicle contact the surface ectoderm, and that neural crest cell migration in the frontonasal region is required to restrict the position of the lens placode (Bailey et al., 2006) + + AAO:0011055 EFO:0003494 EHDAA2:0000982 @@ -287235,7 +102671,6 @@ The modern definition of neurosecretion has evolved to include the release of an TAO:0000122 UMLS:C1517770 VHOG:0000166 - Wikipedia:Lens_placode XAO:0000240 ZFA:0000122 uberon @@ -287247,7 +102682,7 @@ The modern definition of neurosecretion has evolved to include the release of an lens placode - http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png + http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png @@ -287264,33 +102699,33 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]. - Wikipedia:Lens_placode - ZFIN:curator + + ZFIN:curator Ectodermal primordium of the lens of the eye. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000122 - TAO - ZFIN:curator + TAO + ZFIN:curator (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000166 - VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 - http://bgee.unil.ch/ + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 @@ -287309,13 +102744,13 @@ The modern definition of neurosecretion has evolved to include the release of an lens placodes ZFA:0000122 - + placoda lentis - Wikipedia:Lens_placode + @@ -287355,6 +102790,8 @@ The modern definition of neurosecretion has evolved to include the release of an A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] + + AAO:0011072 BTO:0001765 DHBA:10153 @@ -287369,7 +102806,6 @@ The modern definition of neurosecretion has evolved to include the release of an TAO:0000132 UMLS:C0920623 VHOG:0000068 - Wikipedia:Neural_plate XAO:0000249 ZFA:0000132 neuronames:1362 @@ -287381,13 +102817,13 @@ The modern definition of neurosecretion has evolved to include the release of an neural plate - https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png + https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png - GO + GO @@ -287409,7 +102845,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia @@ -287420,35 +102856,35 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]. + ISBN:0815318960 OMD:neural+plate - Wikipedia:Neural_plate - ZFIN:curator + ZFIN:curator The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000132 - TAO - ZFIN:curator + TAO + ZFIN:curator (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000068 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 - http://bgee.unil.ch/ @@ -287460,7 +102896,7 @@ The modern definition of neurosecretion has evolved to include the release of an lamina neuralis - Wikipedia:Neural_plate + @@ -287469,6 +102905,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -287497,17 +102934,17 @@ The modern definition of neurosecretion has evolved to include the release of an - lexical + lexical (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001383 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 - http://bgee.unil.ch/ @@ -287552,17 +102989,18 @@ The modern definition of neurosecretion has evolved to include the release of an Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO] Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG] note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here) + + + AAO:0010568 EFO:0003515 EMAPA:16183 EMAPA:16751 FMA:293145 NCIT:C34244 - SCTID:361475002 TAO:0000255 UMLS:C1284009 VHOG:0000114 - Wikipedia:Paraxial_mesoderm XAO:0000259 ZFA:0000255 paraxial mesenchyme @@ -287574,13 +103012,13 @@ The modern definition of neurosecretion has evolved to include the release of an paraxial mesoderm - http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png + http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - EHDAA2 + EHDAA2 @@ -287591,33 +103029,33 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]. + GO:0048339 - https://github.com/obophenotype/uberon/issues/30 Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010568 - AAO - AAO:EJS + AAO + AAO:EJS Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000114 - VHOG + VHOG + DOI:10.1002/dvdy.21177 Kusakabe R and Kuratani S. Evolutionary perspectives from development of mesodermal components in the lamprey. Developmental dynamics (2007) - http://bgee.unil.ch/ @@ -287635,9 +103073,9 @@ The modern definition of neurosecretion has evolved to include the release of an paraxial mesenchyme + + ZFA:0000255 - https://github.com/obophenotype/uberon/issues/30 - https://github.com/obophenotype/uberon/wiki/The-neural-crest @@ -287649,7 +103087,7 @@ The modern definition of neurosecretion has evolved to include the release of an mesoderma paraxiale - Wikipedia:Paraxial_mesoderm + @@ -287707,7 +103145,7 @@ The modern definition of neurosecretion has evolved to include the release of an NCBIBook:NBK53175 - ZFA + ZFA @@ -287718,7 +103156,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -287729,7 +103167,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2-abduced + EHDAA2-abduced @@ -287741,20 +103179,20 @@ The modern definition of neurosecretion has evolved to include the release of an Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia. [Graham_A, The_development_and_evolution_of_the_pharyngeal_arches._J_Anat_(2001)_199:_133-141][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000117 - VHOG - http://bgee.unil.ch/ + VHOG + These (the epibranchial placodes) are focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches in all vertebrates, and they produce the neuroblasts which migrate and condense to form the distal cranial ganglia: the geniculate, petrosal and nodose ganglia. (...) The one substantial difference between the vertebrate pharyngeal arches and those of the protochordates is the presence of the epibranchial placodes but the evolution of these structures was undoubtedly driven by the endoderm.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000117 - VHOG + VHOG + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A, The development and evolution of the pharyngeal arches. J Anat (2001) - http://bgee.unil.ch/ @@ -287766,20 +103204,20 @@ The modern definition of neurosecretion has evolved to include the release of an in XAO this develops_from dorsolateral placode, but in NBK53175, this is a separate group - XAO + XAO epibranchial placodes ZFA:0001294 - + ventrolateral placode - ISBN:0471888893 + ISBN:0471888893 @@ -287787,6 +103225,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -287821,17 +103260,17 @@ The modern definition of neurosecretion has evolved to include the release of an - lexical + lexical (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001384 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 - http://bgee.unil.ch/ @@ -287873,17 +103312,18 @@ The modern definition of neurosecretion has evolved to include the release of an A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG] subclass of mesoderm in ZFA. UBERON:0006258 + + + AAO:0010574 EHDAA2:0000919 EHDAA:379 EMAPA:16179 FMA:293149 NCIT:C34199 - SCTID:361477005 TAO:0000121 UMLS:C1517749 VHOG:0000118 - Wikipedia:Lateral_plate_mesoderm XAO:0000311 ZFA:0000121 LPM @@ -287896,13 +103336,13 @@ The modern definition of neurosecretion has evolved to include the release of an lateral plate mesoderm - http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png + http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - EHDAA2 + EHDAA2 @@ -287913,8 +103353,8 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 - VHOG + EHDAA2 + VHOG @@ -287925,43 +103365,43 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 - XAO + EHDAA2 + XAO Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]. + MP:0010117 - Wikipedia:Lateral_plate_mesoderm Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010574 - AAO - AAO:EJS + AAO + AAO:EJS The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000118 - VHOG - http://bgee.unil.ch/ + VHOG + A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000118 - VHOG + VHOG + DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000) - http://bgee.unil.ch/ @@ -287980,7 +103420,7 @@ The modern definition of neurosecretion has evolved to include the release of an LPM ZFA:0000121 - + @@ -287998,7 +103438,7 @@ The modern definition of neurosecretion has evolved to include the release of an mesoderma laminae lateralis - Wikipedia:Lateral_plate_mesoderm + @@ -288007,6 +103447,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -288030,6 +103471,9 @@ The modern definition of neurosecretion has evolved to include the release of an The term 'myotome' is also used to describe the muscles served by a single nerve root / spinal segment - consider adding new class, myomere. Portion of the somites giving rise to body wall muscle masses. Kimmel et al, 1995.[TAO] In all vertebrates, the skeletal muscle of the body axis is chiefly derived from an early embryonic compartment, known as the myotome.[well established][VHOG] + + + AAO:0011067 AEO:0001018 BTO:0000742 @@ -288041,11 +103485,9 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:32841 FMA:295658 NCIT:C34214 - SCTID:344535001 TAO:0001056 UMLS:C1513802 VHOG:0001244 - Wikipedia:Myotome XAO:0000315 ZFA:0001056 myomeres @@ -288060,13 +103502,13 @@ The modern definition of neurosecretion has evolved to include the release of an myotome - http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png + http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png - AEO + AEO @@ -288077,8 +103519,8 @@ The modern definition of neurosecretion has evolved to include the release of an - WP - ZFA + WP + ZFA @@ -288089,7 +103531,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2-abduced + EHDAA2-abduced @@ -288101,20 +103543,20 @@ The modern definition of neurosecretion has evolved to include the release of an Portion of the somites giving rise to body wall muscle masses. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001056 - TAO - ZFIN:curator + TAO + ZFIN:curator In all vertebrates, the skeletal muscle of the body axis is chiefly derived from an early embryonic compartment, known as the myotome.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001244 - VHOG + VHOG + DOI:10.1038/sj.embor.embor920 Hollway GE, Currie PD, Myotome meanderings. Cellular morphogenesis and the making of muscle. EMBO Rep.(2003) - http://bgee.unil.ch/ @@ -288127,13 +103569,13 @@ The modern definition of neurosecretion has evolved to include the release of an myomeres TAO:0001056 - + myotomus - Wikipedia:Myotome + @@ -288144,7 +103586,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -288160,12 +103601,12 @@ The modern definition of neurosecretion has evolved to include the release of an Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]. Post-cranial portion of the neural crest. Exact anatomical derivations not experimentally resolved in amphibians.[AAO] We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] + AAO:0010582 EFO:0003605 EHDAA2:0001901 TAO:0001024 VHOG:0000062 - Wikipedia:Trunk_neural_crest XAO:0000319 ZFA:0001024 TNC @@ -288185,40 +103626,40 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]. + ISBN:0815318960 - Wikipedia:Trunk_neural_crest Post-cranial portion of the neural crest. Exact anatomical derivations not experimentally resolved in amphibians.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010582 - AAO - AAO:EJS + AAO + AAO:EJS We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000062 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 - http://bgee.unil.ch/ TNC XAO:0000319 - + @@ -288227,6 +103668,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -288256,6 +103698,7 @@ The modern definition of neurosecretion has evolved to include the release of an Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO] The fused aspects of ventral mesoderm, which have migrated from either side of the prechordal plate, and fused ventrally, just behind the cement gland. They will give rise to the endocardium at NF stage 27&28.[AAO] relationship loss: develops_from lateral mesoderm (TAO:0001065)[TAO] + AAO:0011044 BTO:0001887 NCIT:C34276 @@ -288274,7 +103717,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Obol + Obol @@ -288285,7 +103728,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -288296,7 +103739,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -288307,39 +103750,39 @@ The modern definition of neurosecretion has evolved to include the release of an - XAO + XAO Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone. - ZFIN:curator + ZFIN:curator Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000028 - TAO - ZFIN:curator + TAO + ZFIN:curator The fused aspects of ventral mesoderm, which have migrated from either side of the prechordal plate, and fused ventrally, just behind the cement gland. They will give rise to the endocardium at NF stage 27&28.[AAO] - 2012-06-20 + 2012-06-20 AAO:0011044 - AAO + AAO XAO:curator relationship loss: develops_from lateral mesoderm (TAO:0001065)[TAO] - 2012-08-14 + 2012-08-14 TAO:0000028 - TAO + TAO @@ -288368,18 +103811,19 @@ The modern definition of neurosecretion has evolved to include the release of an - + - + + - + @@ -288396,18 +103840,18 @@ The modern definition of neurosecretion has evolved to include the release of an - + Extension of the dorsal aorta in the tail. Extension of the dorsal aorta in the tail. Kimmel et al, 1995.[TAO] The posterior extension of the dorsal aorta to the tail region, which degenerates at metamorphosis.[AAO] + AAO:0011023 EFO:0003472 TAO:0000011 VHOG:0000123 - Wikipedia:Caudal_artery XAO:0000364 ZFA:0000011 uberon @@ -288421,25 +103865,25 @@ The modern definition of neurosecretion has evolved to include the release of an Extension of the dorsal aorta in the tail. - Wikipedia:Caudal_artery - ZFIN:curator + + ZFIN:curator Extension of the dorsal aorta in the tail. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000011 - TAO - ZFIN:curator + TAO + ZFIN:curator The posterior extension of the dorsal aorta to the tail region, which degenerates at metamorphosis.[AAO] - 2012-06-20 + 2012-06-20 AAO:0011023 - AAO + AAO ISBN:0-226-55763-4 @@ -288466,9 +103910,10 @@ The modern definition of neurosecretion has evolved to include the release of an Skeletogenic portion of somites.[AAO] The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG] part_of somite in XAO + + AAO:0010571 AEO:0000212 - BTO:0006255 EHDAA2:0003439 EMAPA:31159 FMA:295652 @@ -288476,7 +103921,6 @@ The modern definition of neurosecretion has evolved to include the release of an TAO:0001080 UMLS:C0183176 VHOG:0000680 - Wikipedia:Sclerotome XAO:0000397 ZFA:0001080 sclerotomes @@ -288487,19 +103931,19 @@ The modern definition of neurosecretion has evolved to include the release of an sclerotome - http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png + http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png - EHDAA2 + EHDAA2 - EHDAA2 + EHDAA2 @@ -288521,46 +103965,40 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. - Wikipedia:Sclerotome + + XB:curator - https://github.com/obophenotype/uberon/issues/316 Skeletogenic portion of somites.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010571 - AAO - AAO:EJS + AAO + AAO:EJS The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000680 - VHOG + VHOG + DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000) - http://bgee.unil.ch/ part_of somite in XAO - XAO - - - - - BTO:0006255 - https://orcid.org/0000-0003-4423-4370 + XAO @@ -288573,13 +104011,13 @@ The modern definition of neurosecretion has evolved to include the release of an sclerotomes TAO:0001080 - + sclerotomus - Wikipedia:Sclerotome + @@ -288607,13 +104045,13 @@ The modern definition of neurosecretion has evolved to include the release of an Anterior most portion of the neural crest. Migrates in three highly conserved streams: mandibular, hyoid and branchial.[AAO] Neural crest that is part of the head.[TAO] We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] + AAO:0010580 EFO:0003645 EHDAA2:0004420 EMAPA:16091 TAO:0001194 VHOG:0000063 - Wikipedia:Cranial_neural_crest XAO:0001001 ZFA:0001194 CNC @@ -288634,42 +104072,42 @@ The modern definition of neurosecretion has evolved to include the release of an Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage. - MGI:anna + MGI:anna Anterior most portion of the neural crest. Migrates in three highly conserved streams: mandibular, hyoid and branchial.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010580 - AAO - AAO:EJS + AAO + AAO:EJS Neural crest that is part of the head.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001194 - TAO - ZFIN:curator + TAO + ZFIN:curator We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000063 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 - http://bgee.unil.ch/ CNC XAO:0001001 - + @@ -288681,7 +104119,7 @@ The modern definition of neurosecretion has evolved to include the release of an crista neuralis cranialis - Wikipedia:Cranial_neural_crest + @@ -288693,13 +104131,13 @@ The modern definition of neurosecretion has evolved to include the release of an Gonochoristic organism that can produce female gametes. + AAO:0010030 BILA:0000028 CARO:0000028 FBbt:00007011 FMA:67812 HAO:0000028 - SCTID:362608006 TAO:0000303 TGMA:0001839 XAO:0003005 @@ -288749,12 +104187,12 @@ The modern definition of neurosecretion has evolved to include the release of an Organism subdivision which is the collection of anatomical structures on the body surface.[ZFA] + AAO:0010337 AEO_RETIRED:0000010 EHDAA2_RETIRED:0003010 TAO:0000292 VSAO:0000001 - Wikipedia:Surface_structure XAO:0003028 ZFA:0000292 galen:SurfaceRegion @@ -288771,17 +104209,17 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism. - http://orcid.org/0000-0002-6601-2165 - https://github.com/obophenotype/uberon/issues/24 + + Organism subdivision which is the collection of anatomical structures on the body surface.[ZFA] - 2012-08-14 + 2012-08-14 TAO:0000292 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -288794,7 +104232,7 @@ The modern definition of neurosecretion has evolved to include the release of an surface structures ZFA:0000292 - + @@ -288871,6 +104309,8 @@ The modern definition of neurosecretion has evolved to include the release of an A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO] Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO] mesenchymal + + AAO:0010427 AEO:0000145 BTO:0001393 @@ -288881,7 +104321,6 @@ The modern definition of neurosecretion has evolved to include the release of an TAO:0000393 UMLS:C0162415 VHOG:0000170 - Wikipedia:Mesenchyme XAO:0003046 ZFA:0000393 mesenchymal tissue @@ -288895,33 +104334,33 @@ The modern definition of neurosecretion has evolved to include the release of an mesenchyme - http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg + http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme. - https://archive.org/details/invertebratesnde00brus/page/n240/mode/2up - https://en.wikipedia.org/wiki/Mesenchyme - https://github.com/obophenotype/uberon/issues/1641 + + + A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000393 - TAO - ZFIN:curator + TAO + ZFIN:curator Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010427 - AAO - AAO:EJS + AAO + AAO:EJS @@ -288933,7 +104372,7 @@ The modern definition of neurosecretion has evolved to include the release of an mesenchyma - Wikipedia:Mesenchyme + @@ -288942,6 +104381,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -288980,19 +104420,19 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the peripheral olfactory organ.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000351 - TAO + TAO TAO:MAH Anatomical cluster that is located in the anterior region of the neurocranium and provides structural support for the olfactory organs.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010206 - AAO - AAO:EJS + AAO + AAO:EJS @@ -289022,7 +104462,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -289046,10 +104486,10 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical cluster that is part of the cranium and composed of dermally derived bones.[TAO] Anatomical cluster that is part of the cranium which consists of dermally derived bones.[AAO] + AAO:0010154 TAO:0000863 VHOG:0001665 - Wikipedia:Skull_roof XAO:0003169 ZFA:0000863 dendrocranium @@ -289076,38 +104516,38 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified]. - Wikipedia:Skull_roof + ZFA:0000863 - ISBN:0073040584 + ISBN:0073040584 Anatomical cluster that is part of the cranium and composed of dermally derived bones.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000863 - TAO - ZFIN:curator + TAO + ZFIN:curator Anatomical cluster that is part of the cranium which consists of dermally derived bones.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010154 - AAO - AAO:BJB + AAO + AAO:BJB @@ -289125,21 +104565,21 @@ The modern definition of neurosecretion has evolved to include the release of an dermal skull roof - PMID:11523816 - Wikipedia:Skull_roof + + roof of skull - Wikipedia:Skull_roof + skull roof - PMID:11523816 - Wikipedia:Skull_roof + + @@ -289151,7 +104591,7 @@ The modern definition of neurosecretion has evolved to include the release of an roofing bones of the skull - Wikipedia:Skull_roof + @@ -289165,12 +104605,12 @@ The modern definition of neurosecretion has evolved to include the release of an A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG] in XAO, called branchial arch 2 and df VP4 4 + AAO:0010366 EHDAA2:0000086 EHDAA:1663 EMAPA:16760 FMA:293035 - SCTID:308770007 TAO:0001599 VHOG:0000299 XAO:0000449 @@ -289203,26 +104643,26 @@ The modern definition of neurosecretion has evolved to include the release of an The second pharyngeal/branchial arch; arises as a thickening of the pharygeal wall between the first and second branchial clefts; contains the second aortic arch; forms part of the hyoid bone, tongue and facial musculature.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010366 - AAO + AAO ISBN:0-02-377110-0 A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000299 - VHOG + VHOG + DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) - http://bgee.unil.ch/ in XAO, called branchial arch 2 and df VP4 - XAO + XAO @@ -289283,11 +104723,11 @@ The modern definition of neurosecretion has evolved to include the release of an A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG] 6 UBERON:0004349 + AAO:0010368 EHDAA2:0004075 EMAPA:32766 FMA:293047 - SCTID:308772004 TAO:0001601 VHOG:0001205 XAO:0000453 @@ -289317,20 +104757,20 @@ The modern definition of neurosecretion has evolved to include the release of an The forth in a series of paired bars in the wall of the pharynx, within which are formed the forth aortic arch and the cartilage bar of the visceral skeleton, forms and supports the gills.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010368 - AAO + AAO ISBN:0-02-377110-0 A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001205 - VHOG + VHOG + DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M, Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) - http://bgee.unil.ch/ @@ -289422,11 +104862,11 @@ The modern definition of neurosecretion has evolved to include the release of an Disappears early in development in tetrapods ZFA states that The paired aortic arch 1 arteries branch off of the ventral aorta, and empty into the right and left lateral dorsal aortas UBERON:0004371 + AAO:0010415 EHDAA2:0000007 EMAPA:16202 EMAPA:16685 - SCTID:308774003 TAO:0005005 VHOG:0000149 XAO:0000342 @@ -289543,12 +104983,12 @@ The modern definition of neurosecretion has evolved to include the release of an The fourth right arch forms the right subclavian as far as the origin of its internal mammary branch; while the fourth left arch constitutes the arch of the aorta between the origin of the left carotid artery and the termination of the ductus arteriosus[WP][Wikipedia:Aortic_arches#Arch_4]. Normally, the left fourth arch becomes the aortic arch, the right fourth arch contributes to the innominate artery[http://emedicine.medscape.com/article/899609-overview] in birds it is the right fourth arch which forms the permanent aorta UBERON:0004350 + + AAO:0010420 EHDAA2:0000087 EMAPA:17004 - SCTID:308777005 TAO:0005008 - Wikipedia:Aortic_arches#Arch_4 XAO:0000355 ZFA:0005008 4th arch artery @@ -289577,25 +105017,25 @@ The modern definition of neurosecretion has evolved to include the release of an Aortic arches 3 and 4 are not remodeled but are retained largely intact as the branchial arteries providing circulation through the gills. These areches are direct branches from the ventral aorta to the lateral dorsal aorta. Isogai et al. 2001.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005008 - TAO - ZFIN:curator + TAO + ZFIN:curator The forth in a series paired arterial connections between the dorsal and ventral aortae, lies within the 4th branchial arch. The paired aortic arch 4 arteries branch directly from the ventral aorta to the lateral dorsal aorta, and are retained as the branchial arteries providing circulation through the gills in the adult.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010420 - AAO + AAO ISBN:0-02-377110-0 The fourth right arch forms the right subclavian as far as the origin of its internal mammary branch; while the fourth left arch constitutes the arch of the aorta between the origin of the left carotid artery and the termination of the ductus arteriosus[WP][Wikipedia:Aortic_arches#Arch_4]. - Wikipedia:Aortic_arches#Arch_4 + @@ -289643,7 +105083,7 @@ The modern definition of neurosecretion has evolved to include the release of an systemic arch - ISBN:0073040584 + ISBN:0073040584 XAO:0000355 @@ -289676,13 +105116,13 @@ The modern definition of neurosecretion has evolved to include the release of an The sixth right arch disappears; the sixth left arch gives off the pulmonary arteries and forms the ductus arteriosus; this duct remains pervious during the whole of fetal life, but then closes within the first few days after birth due to increased O2 concentration. Oxygen concentration causes the production of bradykinin which causes the ductus to constrict occluding all flow. Within 1-3 months, the ductus is obliterated and becomes the ligamentum arteriosus. His showed that in the early embryo the right and left arches each gives a branch to the lungs, but that later both pulmonary arteries take origin from the left arch[WP][Wikipedia:Aortic_arches#Arch_6]. the distal left sixth arch becomes the ductus arteriosus, the proximal sixth arches bilaterally contribute to the proximal branch pulmonary arteries UBERON:0004351 + + AAO:0010422 EHDAA2:0000102 EMAPA:17005 - SCTID:308779008 TAO:0005016 VHOG:0000144 - Wikipedia:Aortic_arches#Arch_6 XAO:0000353 ZFA:0005016 6th arch artery @@ -289710,31 +105150,31 @@ The modern definition of neurosecretion has evolved to include the release of an The fifth and sixth arches, which come on-line at approximately 2.5 dpf, have a common trunk from the ventral aorta and drain to the midline dorsal aorta via an independent route. The fifth and sixth aortic arches supply the trunk and tail with oxigenated blood. Isogai et al. 2001.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005016 - TAO - ZFIN:curator + TAO + ZFIN:curator The sixth in a series paired arterial connections between the dorsal and ventral aortae. Aortic arch 6 artery is paired and has a common trunk with aortic arch 5 from the ventral aorta, and drains via a separate branch of the lateral dorsal aorta. It forms part of the pulmonary arteries, and in the later embryo, the ductus arteriosis. Aortic arches 5 and 6 together supply the trunk and tail with oxygenated blood.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010422 - AAO + AAO ISBN:0-02-377110-0 The sixth right arch disappears; the sixth left arch gives off the pulmonary arteries and forms the ductus arteriosus; this duct remains pervious during the whole of fetal life, but then closes within the first few days after birth due to increased O2 concentration. Oxygen concentration causes the production of bradykinin which causes the ductus to constrict occluding all flow. Within 1-3 months, the ductus is obliterated and becomes the ligamentum arteriosus. His showed that in the early embryo the right and left arches each gives a branch to the lungs, but that later both pulmonary arteries take origin from the left arch[WP][Wikipedia:Aortic_arches#Arch_6]. - Wikipedia:Aortic_arches#Arch_6 + the distal left sixth arch becomes the ductus arteriosus, the proximal sixth arches bilaterally contribute to the proximal branch pulmonary arteries - http://emedicine.medscape.com/article/899609-overview + @@ -289782,7 +105222,159 @@ The modern definition of neurosecretion has evolved to include the release of an pulmonary arch - ISBN:0073040584 + ISBN:0073040584 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]. + + An elongated tube which carries air to and from the lungs.[AAO] + The respiratory tube between the larynx and the bronchi. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] + In primitive fishes and most tetrapods, the lungs of adults are usually paired. They lie ventral to the digestive tract and are connected to the outside environment through the trachea.[well established][VHOG] + tracheal + In birds, the trachea runs from the pharynx to the syrinx, from which the primary bronchi diverge. Swans have an unusually elongated trachea, part of which is coiled beneath the sternum; this may act as a resonator to amplify sound. In some birds, the cartilagenous rings are complete, and may even be ossified. In amphibians, the trachea is normally extremely short, and leads directly into the lungs, without clear primary bronchi. A longer trachea is, however found in some long-necked salamanders, and in caecilians. While there are irregular cartilagenous nodules on the amphibian trachea, these do not form the rings found in amniotes. The only vertebrate to have lungs, but no trachea, is Polypterus, in which the lungs arise directly from the pharynx. + in mouse 15-18 C-rings, 15-20 in human. + + + + AAO:0010140 + BTO:0001388 + CALOHA:TS-1060 + EFO:0000935 + EHDAA2:0002066 + EHDAA:3078 + EMAPA:16853 + EV:0100040 + FMA:7394 + GAID:361 + MA:0000441 + MAT:0000137 + MESH:D014132 + MIAA:0000137 + NCIT:C12428 + OpenCyc:Mx4rvViOX5wpEbGdrcN5Y29ycA + UMLS:C0040578 + VHOG:0000371 + XAO:0000118 + cartilaginous trachea + vertebrate trachea + windpipe + uberon + tracheal tubule + UBERON:0003126 + + + + + + trachea + http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg + http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg + + + + + + + + + + + EHDAA2 + + + + + The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]. + + GO:0060438 + + + + + An elongated tube which carries air to and from the lungs.[AAO] + 2012-06-20 + AAO:0010140 + AAO + AAO:BJB + + + + + The respiratory tube between the larynx and the bronchi. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] + 2012-09-17 + VHOG:0000371 + VHOG + + + + + + In primitive fishes and most tetrapods, the lungs of adults are usually paired. They lie ventral to the digestive tract and are connected to the outside environment through the trachea.[well established][VHOG] + 2012-09-17 + VHOG:0000371 + VHOG + + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.409 + + + + + in mouse 15-18 C-rings, 15-20 in human. + ISBN:0123813611 + + + + + UMLS:C0040578 + ncithesaurus:Trachea + + + + + vertebrate trachea + + + + + + tracheal tubule + BTO:0001388 @@ -289791,12 +105383,19 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + Upper portion of the skull that excludes the mandible (when present in the organism). - cranial the inclusion of the FMA class here is probably not quite correct, as this class includes as parts sutures, whereas this is not part of the bones of the cranium The term cranium can be ambiguous, in that it can refer to the neurocranium, or the neurocranium and the Facial skeleton + + BTO:0001328 EFO:0000831 EHDAA:6029 @@ -289805,9 +105404,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000316 MAT:0000340 MIAA:0000340 - SCTID:181889008 + OpenCyc:Mx4rvVlEyJwpEbGdrcN5Y29ycA VHOG:0000334 - Wikipedia:Cranium_(anatomy) bones of cranium ossa cranii set of bones of cranium @@ -289834,20 +105432,20 @@ The modern definition of neurosecretion has evolved to include the release of an Upper portion of the skull that excludes the mandible (when present in the organism). - Wikipedia:Cranium_(anatomy) - http://orcid.org/0000-0002-6601-2165 + + the inclusion of the FMA class here is probably not quite correct, as this class includes as parts sutures, whereas this is not part of the bones of the cranium - FMA + FMA The term cranium can be ambiguous, in that it can refer to the neurocranium, or the neurocranium and the Facial skeleton - WP + WP @@ -289860,7 +105458,7 @@ The modern definition of neurosecretion has evolved to include the release of an ossa cranii FMA:71325 - FMA:TA + FMA:TA @@ -289914,9 +105512,13 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]. + in FMA the skull is divided into orbit, neurocranium (8 parts), viscerocranium (26 parts). Here we have a separate overlapping division into cranium and mandible. in many ontologies, the structure called the cranium is inclusive of the mandible/lower jaw skeleton A skull that is missing a mandible is only a cranium; this is the source of a very commonly made error in terminology. Those animals having skulls are called craniates + + + BTO:0001295 CALOHA:TS-2344 EHDAA2:0000325 @@ -289925,9 +105527,8 @@ The modern definition of neurosecretion has evolved to include the release of an GAID:82 MESH:D012886 NCIT:C12789 - SCTID:110530005 + OpenCyc:Mx4rvVjOsZwpEbGdrcN5Y29ycA UMLS:C0037303 - Wikipedia:Skull WikipediaCategory:Skull galen:Skull uberon @@ -289942,27 +105543,27 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]. - PMID:11523816 - Wikipedia:Skull - http://sourceforge.net/tracker/?func=detail&aid=2962656&group_id=76834&atid=1205376 + + + in FMA the skull is divided into orbit, neurocranium (8 parts), viscerocranium (26 parts). Here we have a separate overlapping division into cranium and mandible. - FMA + FMA A skull that is missing a mandible is only a cranium; this is the source of a very commonly made error in terminology. Those animals having skulls are called craniates - WP + WP @@ -290003,12 +105604,14 @@ The modern definition of neurosecretion has evolved to include the release of an An organ involved in reproduction. GO uses genitalia for the singular organ + + EMAPA:17381 EMAPA:37731 MA:0001752 MESH:D005835 NCIT:C25177 - SCTID:128181006 + OpenCyc:Mx4rwO39aJwpEbGdrcN5Y29ycA TGMA:0000591 UMLS:C0017420 WBbt:0008422 @@ -290039,7 +105642,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37731 - MA:th + MA:th @@ -290051,7 +105654,7 @@ The modern definition of neurosecretion has evolved to include the release of an genitalia - + @@ -290113,25 +105716,25 @@ The modern definition of neurosecretion has evolved to include the release of an female organism reproductive organ - OBOL:automatic + OBOL:automatic female organism reproductive structure - OBOL:automatic + OBOL:automatic female organism reproductive system organ - OBOL:automatic + OBOL:automatic female organism sex organ - OBOL:automatic + OBOL:automatic @@ -290143,25 +105746,25 @@ The modern definition of neurosecretion has evolved to include the release of an reproductive organ of female organism - OBOL:automatic + OBOL:automatic reproductive structure of female organism - OBOL:automatic + OBOL:automatic reproductive system organ of female organism - OBOL:automatic + OBOL:automatic sex organ of female organism - OBOL:automatic + OBOL:automatic @@ -290180,6 +105783,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -290242,49 +105846,49 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a upper jaw [Automatically generated definition]. - OBOL:automatic + OBOL:automatic epithelial tissue of palatoquadrate arch - OBOL:automatic + OBOL:automatic epithelial tissue of upper jaw - OBOL:automatic + OBOL:automatic epithelium of palatoquadrate arch - OBOL:automatic + OBOL:automatic palatoquadrate arch epithelial tissue - OBOL:automatic + OBOL:automatic palatoquadrate arch epithelium - OBOL:automatic + OBOL:automatic upper jaw epithelial tissue - OBOL:automatic + OBOL:automatic upper jaw epithelium - OBOL:automatic + OBOL:automatic @@ -290303,6 +105907,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -290330,49 +105935,49 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a lower jaw [Automatically generated definition]. - OBOL:automatic + OBOL:automatic epithelial tissue of lower jaw - OBOL:automatic + OBOL:automatic epithelial tissue of ventral mandibular arch - OBOL:automatic + OBOL:automatic epithelium of ventral mandibular arch - OBOL:automatic + OBOL:automatic lower jaw epithelial tissue - OBOL:automatic + OBOL:automatic lower jaw epithelium - OBOL:automatic + OBOL:automatic ventral mandibular arch epithelial tissue - OBOL:automatic + OBOL:automatic ventral mandibular arch epithelium - OBOL:automatic + OBOL:automatic @@ -290429,13 +106034,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 The portion of the yolk sac that is derived from endoderm and lines the yolk sac. - UBERON:cjm + UBERON:cjm @@ -290486,13 +106091,13 @@ The modern definition of neurosecretion has evolved to include the release of an An endoderm that is part of a foregut [Automatically generated definition]. - OBOL:automatic + OBOL:automatic foregut endoderm - OBOL:automatic + OBOL:automatic @@ -290545,13 +106150,13 @@ The modern definition of neurosecretion has evolved to include the release of an An endoderm that is part of a midgut [Automatically generated definition]. - OBOL:automatic + OBOL:automatic midgut endoderm - OBOL:automatic + OBOL:automatic @@ -290602,13 +106207,13 @@ The modern definition of neurosecretion has evolved to include the release of an An endoderm that is part of a hindgut [Automatically generated definition]. - OBOL:automatic + OBOL:automatic hindgut endoderm - OBOL:automatic + OBOL:automatic @@ -290651,25 +106256,25 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition]. - OBOL:automatic + OBOL:automatic eye skeletal muscle - OBOL:automatic + OBOL:automatic eye skeletal muscle tissue - OBOL:automatic + OBOL:automatic skeletal muscle tissue of eye - OBOL:automatic + OBOL:automatic @@ -290736,23 +106341,23 @@ The modern definition of neurosecretion has evolved to include the release of an A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones. - http://orcid.org/0000-0002-6601-2165 + The jaw joint of all jawed vertebrates, except for mammals, involves the quadrate and articular bones, or the posterior ends of the palatoquadrate and mandibular cartilages; A correlate of the conversion of the articular and quadrate bones to the malleus and incus is that all adult mammals have a jaw joint that lies between the dentary of the lower jaw and the squamosal bone of the skull roof.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000429 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.241 and p.101 - http://bgee.unil.ch/ EMAPA/MA placement unclear. See https://github.com/obophenotype/mouse-anatomy-ontology/issues/102 - EMAPA + EMAPA @@ -290837,7 +106442,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -290854,38 +106459,43 @@ The modern definition of neurosecretion has evolved to include the release of an A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage. - http://orcid.org/0000-0002-6601-2165 + The ventral portion of the first pharyngeal arch, comprising the lower jaw.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001273 - TAO - ZFIN:curator + TAO + ZFIN:curator The jaw joint of all jawed vertebrates, except for mammals, involves the quadrate and articular bones, or the posterior ends of the palatoquadrate and mandibular cartilages; A correlate of the conversion of the articular and quadrate bones to the malleus and incus is that all adult mammals have a jaw joint that lies between the dentary of the lower jaw and the squamosal bone of the skull roof.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000428 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.241 and p.101 - http://bgee.unil.ch/ Inclusion of the FMA class 'lower jaw' is debatable - this mostly corresponds to the lower jaw skeleton (with 'maxillary part of mouth' corresponding to the upper jaw region); however, the FMA class also includes gingiva. See also: https://github.com/obophenotype/mouse-anatomy-ontology/issues/102 - FMA + FMA lower jaw MA:0001906 + + + + + lower jaw ZFA:0001273 @@ -290905,7 +106515,7 @@ The modern definition of neurosecretion has evolved to include the release of an mandibles TAO:0001273 - + @@ -290916,6 +106526,66 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + An endothelium that is part of a trachea. + EHDAA:3082 + RETIRED_EHDAA2:0002068 + endothelium of windpipe + trachea endothelium + windpipe endothelium + uberon + UBERON:0003279 + endothelium of trachea + + + + + An endothelium that is part of a trachea. + OBOL:automatic + + + + + endothelium of windpipe + OBOL:automatic + + + + + trachea endothelium + OBOL:automatic + + + + + windpipe endothelium + OBOL:automatic + + + + @@ -290946,11 +106616,11 @@ The modern definition of neurosecretion has evolved to include the release of an The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum. TODO - check primitive vs developed The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum. [TFD][VHOG] + EHDAA2:0001922 EHDAA:2999 EMAPA:17024 MA:0001617 - SCTID:261623000 VHOG:0000358 mesentery of ventriculus mesogaster @@ -290967,7 +106637,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -290978,35 +106648,35 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum. - http://medical-dictionary.thefreedictionary.com/mesogastrium + The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000358 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/mesogastrium + VHOG + + mesentery of ventriculus - OBOL:automatic + OBOL:automatic mesogaster - http://medical-dictionary.thefreedictionary.com/mesogastrium + @@ -291018,7 +106688,7 @@ The modern definition of neurosecretion has evolved to include the release of an mesogastrium - http://www.vivo.colostate.edu/hbooks/pathphys/misc_topics/peritoneum.html + @@ -291030,7 +106700,7 @@ The modern definition of neurosecretion has evolved to include the release of an ventriculus mesentery - OBOL:automatic + OBOL:automatic @@ -291072,13 +106742,13 @@ The modern definition of neurosecretion has evolved to include the release of an A mesentery that surrounds the heart. - MA:th + MA:th heart mesentery - OBOL:automatic + OBOL:automatic @@ -291138,17 +106808,17 @@ The modern definition of neurosecretion has evolved to include the release of an A mesentery that is part of a esophagus [Automatically generated definition]. - OBOL:automatic + OBOL:automatic Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000415 - VHOG + VHOG + ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11 - http://bgee.unil.ch/ @@ -291160,19 +106830,19 @@ The modern definition of neurosecretion has evolved to include the release of an gullet mesentery - OBOL:automatic + OBOL:automatic mesentery of esophagus - OBOL:automatic + OBOL:automatic mesentery of gullet - OBOL:automatic + OBOL:automatic @@ -291221,23 +106891,23 @@ The modern definition of neurosecretion has evolved to include the release of an A mesentery that is part of a midgut [Automatically generated definition]. - OBOL:automatic + OBOL:automatic Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000413 - VHOG + VHOG + ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11 - http://bgee.unil.ch/ midgut mesentery - OBOL:automatic + OBOL:automatic @@ -291277,13 +106947,13 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that is part of a foregut [Automatically generated definition]. - OBOL:automatic + OBOL:automatic foregut gland - OBOL:automatic + OBOL:automatic @@ -291331,13 +107001,13 @@ The modern definition of neurosecretion has evolved to include the release of an - BTO + BTO Racemose mucous glands beneath the mucous membrane of the pharynx. - http://www.biology-online.org/dictionary/ + @@ -291392,25 +107062,25 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that is part of a integumental system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic integumental gland - http://orcid.org/0000-0002-6601-2165 + integumental system gland - http://orcid.org/0000-0002-6601-2165 + integumentary gland - http://orcid.org/0000-0002-6601-2165 + @@ -291467,7 +107137,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -291478,7 +107148,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -291489,32 +107159,32 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 A blood island that is part of a mesoderm. - OBOL:automatic + OBOL:automatic in EHDAA2, gives rise to blood and dorsal aorta - EHDAA2 + EHDAA2 mesoderm blood islands EHDAA2:0003241 - + mesenchyme blood island - OBOL:automatic + OBOL:automatic @@ -291567,19 +107237,19 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that is part of a developing camera-type eye. - OBOL:automatic + OBOL:automatic mesenchyme of eye - OBOL:automatic + OBOL:automatic @@ -291606,7 +107276,6 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a developing ovary [Automatically generated definition]. - EHDAA2:0001362 EHDAA:8128 VHOG:0001441 @@ -291621,68 +107290,67 @@ The modern definition of neurosecretion has evolved to include the release of an ovary mesenchyme uberon UBERON:0003315 - mesenchyme of ovary Mesenchyme that is part of a developing ovary [Automatically generated definition]. - OBOL:automatic + OBOL:automatic female reproductive system gonad mesenchyme - OBOL:automatic + OBOL:automatic female reproductive system gonada mesenchyme - OBOL:automatic + OBOL:automatic gonad of female reproductive system mesenchyme - OBOL:automatic + OBOL:automatic gonada of female reproductive system mesenchyme - OBOL:automatic + OBOL:automatic mesenchyme of female reproductive system gonad - OBOL:automatic + OBOL:automatic mesenchyme of female reproductive system gonada - OBOL:automatic + OBOL:automatic mesenchyme of gonad of female reproductive system - OBOL:automatic + OBOL:automatic mesenchyme of gonada of female reproductive system - OBOL:automatic + OBOL:automatic ovary mesenchyme - OBOL:automatic + OBOL:automatic @@ -291726,13 +107394,13 @@ The modern definition of neurosecretion has evolved to include the release of an The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme. - UBERON:cjm + UBERON:cjm yolk sac mesenchyme - OBOL:automatic + OBOL:automatic @@ -291752,6 +107420,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -291786,31 +107455,31 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that is part of a developing upper jaw [Automatically generated definition]. - OBOL:automatic + OBOL:automatic mesenchyme of palatoquadrate arch - OBOL:automatic + OBOL:automatic palatoquadrate arch mesenchyme - OBOL:automatic + OBOL:automatic upper jaw mesenchyme - OBOL:automatic + OBOL:automatic @@ -291829,6 +107498,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -291863,31 +107533,31 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that is part of a developing lower jaw [Automatically generated definition]. - OBOL:automatic + OBOL:automatic lower jaw mesenchyme - OBOL:automatic + OBOL:automatic mesenchyme of ventral mandibular arch - OBOL:automatic + OBOL:automatic ventral mandibular arch mesenchyme - OBOL:automatic + OBOL:automatic @@ -291916,11 +107586,11 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of an anal canal [Automatically generated definition]. + EMAPA:27217 EMAPA:27227 EMAPA:27535 FMA:85399 - SCTID:7892006 anal canal submucosa anal canal viewed anatomically submucosa anal region submucosa @@ -291937,49 +107607,49 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of an anal canal [Automatically generated definition]. - OBOL:automatic + OBOL:automatic anal canal submucosa - OBOL:automatic + OBOL:automatic anal canal viewed anatomically submucosa - OBOL:automatic + OBOL:automatic anal region submucosa - OBOL:automatic + OBOL:automatic anatomical anal canal submucosa - OBOL:automatic + OBOL:automatic submucosa of anal canal viewed anatomically - OBOL:automatic + OBOL:automatic submucosa of anal region - OBOL:automatic + OBOL:automatic submucosa of anatomical anal canal - OBOL:automatic + OBOL:automatic @@ -292006,10 +107676,10 @@ The modern definition of neurosecretion has evolved to include the release of an The submucous layer of the wall of the rectum. + BTO:0002114 EMAPA:27083 FMA:15034 - SCTID:71683001 rectal submucosa rectum submucosa tela submucosa recti @@ -292033,7 +107703,7 @@ The modern definition of neurosecretion has evolved to include the release of an rectum submucosa - OBOL:automatic + OBOL:automatic @@ -292068,10 +107738,10 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a colon [Automatically generated definition]. + EMAPA:27379 FMA:14985 MA:0003200 - SCTID:61647009 colon submucosa colonic submucosa large bowel submucosa @@ -292085,13 +107755,13 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a colon [Automatically generated definition]. - OBOL:automatic + OBOL:automatic colon submucosa - OBOL:automatic + OBOL:automatic @@ -292103,13 +107773,13 @@ The modern definition of neurosecretion has evolved to include the release of an large bowel submucosa - OBOL:automatic + OBOL:automatic submucosa of large bowel - OBOL:automatic + OBOL:automatic @@ -292137,12 +107807,12 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a duodenum [Automatically generated definition]. + EMAPA:27027 EMAPA:27097 EMAPA:27239 FMA:14943 MA:0003213 - SCTID:76519004 doudenal submucosa duodenal submucosa duodenum submucosa @@ -292155,7 +107825,7 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a duodenum [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -292173,7 +107843,7 @@ The modern definition of neurosecretion has evolved to include the release of an duodenum submucosa - OBOL:automatic + OBOL:automatic @@ -292215,7 +107885,7 @@ The modern definition of neurosecretion has evolved to include the release of an A serous membrane that is part of a rectum [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -292227,19 +107897,19 @@ The modern definition of neurosecretion has evolved to include the release of an rectum serosa - OBOL:automatic + OBOL:automatic rectum serous membrane - OBOL:automatic + OBOL:automatic serous membrane of rectum - OBOL:automatic + OBOL:automatic @@ -292273,10 +107943,10 @@ The modern definition of neurosecretion has evolved to include the release of an A serous membrane that is part of a colon [Automatically generated definition]. + EMAPA:27387 FMA:14990 MA:0003199 - SCTID:90132000 colon serosa colon serous membrane colonic serosa @@ -292295,19 +107965,19 @@ The modern definition of neurosecretion has evolved to include the release of an A serous membrane that is part of a colon [Automatically generated definition]. - OBOL:automatic + OBOL:automatic colon serosa - OBOL:automatic + OBOL:automatic colon serous membrane - OBOL:automatic + OBOL:automatic @@ -292319,31 +107989,31 @@ The modern definition of neurosecretion has evolved to include the release of an large bowel serosa - OBOL:automatic + OBOL:automatic large bowel serous membrane - OBOL:automatic + OBOL:automatic serosa of large bowel - OBOL:automatic + OBOL:automatic serous membrane of colon - OBOL:automatic + OBOL:automatic serous membrane of large bowel - OBOL:automatic + OBOL:automatic @@ -292376,12 +108046,11 @@ The modern definition of neurosecretion has evolved to include the release of an A serous membrane that is part of a duodenum [Automatically generated definition]. - 1st part serosa, 2nd - 4th adventitia + EMAPA:27247 FMA:14948 MA:0003212 - SCTID:1236009 doudenal serosa duodenal serosa duodenum serosa @@ -292390,14 +108059,13 @@ The modern definition of neurosecretion has evolved to include the release of an visceral peritoneum of duodenum uberon UBERON:0003336 - serosa of duodenum A serous membrane that is part of a duodenum [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -292415,19 +108083,19 @@ The modern definition of neurosecretion has evolved to include the release of an duodenum serosa - OBOL:automatic + OBOL:automatic duodenum serous membrane - OBOL:automatic + OBOL:automatic serous membrane of duodenum - OBOL:automatic + OBOL:automatic @@ -292481,13 +108149,13 @@ The modern definition of neurosecretion has evolved to include the release of an we follow MA in including separate classes for ganglion and peripheral nervous system, even though for vertebrates gangia are always in the PNS - MA + MA peripheral nervous system ganglion - OBOL:automatic + OBOL:automatic @@ -292530,31 +108198,31 @@ The modern definition of neurosecretion has evolved to include the release of an A ganglion that is part of a central nervous system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic this has no subclasses in FMA. In EHDAA2 and EMAPA it has only the cranial ganglia - FMA + FMA central nervous system ganglion - OBOL:automatic + OBOL:automatic ganglion of neuraxis - OBOL:automatic + OBOL:automatic neuraxis ganglion - OBOL:automatic + OBOL:automatic @@ -292583,10 +108251,11 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of an anal canal [Automatically generated definition]. + + EMAPA:27531 FMA:74654 NCIT:C60784 - SCTID:362170004 UMLS:C0227414 anal canal mucosa anal canal mucosa of organ @@ -292630,7 +108299,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of an anal canal [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -292642,49 +108311,49 @@ The modern definition of neurosecretion has evolved to include the release of an anal canal mucosa - OBOL:automatic + OBOL:automatic anal canal mucosa of organ - OBOL:automatic + OBOL:automatic anal canal mucous membrane - OBOL:automatic + OBOL:automatic anal canal organ mucosa - OBOL:automatic + OBOL:automatic anal canal viewed anatomically mucosa - OBOL:automatic + OBOL:automatic anal canal viewed anatomically mucosa of organ - OBOL:automatic + OBOL:automatic anal canal viewed anatomically mucous membrane - OBOL:automatic + OBOL:automatic anal canal viewed anatomically organ mucosa - OBOL:automatic + OBOL:automatic @@ -292702,139 +108371,139 @@ The modern definition of neurosecretion has evolved to include the release of an anal region mucosa - OBOL:automatic + OBOL:automatic anal region mucosa of organ - OBOL:automatic + OBOL:automatic anal region mucous membrane - OBOL:automatic + OBOL:automatic anal region organ mucosa - OBOL:automatic + OBOL:automatic anatomical anal canal mucosa - OBOL:automatic + OBOL:automatic anatomical anal canal mucosa of organ - OBOL:automatic + OBOL:automatic anatomical anal canal mucous membrane - OBOL:automatic + OBOL:automatic anatomical anal canal organ mucosa - OBOL:automatic + OBOL:automatic mucosa of anal canal viewed anatomically - OBOL:automatic + OBOL:automatic mucosa of anal region - OBOL:automatic + OBOL:automatic mucosa of anatomical anal canal - OBOL:automatic + OBOL:automatic mucosa of organ of anal canal - OBOL:automatic + OBOL:automatic mucosa of organ of anal canal viewed anatomically - OBOL:automatic + OBOL:automatic mucosa of organ of anal region - OBOL:automatic + OBOL:automatic mucosa of organ of anatomical anal canal - OBOL:automatic + OBOL:automatic mucous membrane of anal canal - OBOL:automatic + OBOL:automatic mucous membrane of anal canal viewed anatomically - OBOL:automatic + OBOL:automatic mucous membrane of anal region - OBOL:automatic + OBOL:automatic mucous membrane of anatomical anal canal - OBOL:automatic + OBOL:automatic organ mucosa of anal canal - OBOL:automatic + OBOL:automatic organ mucosa of anal canal viewed anatomically - OBOL:automatic + OBOL:automatic organ mucosa of anal region - OBOL:automatic + OBOL:automatic organ mucosa of anatomical anal canal - OBOL:automatic + OBOL:automatic @@ -292861,8 +108530,8 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a oral opening [Automatically generated definition]. + EMAPA:26937 - SCTID:362083000 mucosa of oral opening mucosa of oral part of face mucosa of organ of oral opening @@ -292902,193 +108571,193 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a oral opening [Automatically generated definition]. - OBOL:automatic + OBOL:automatic mucosa of oral opening - OBOL:automatic + OBOL:automatic mucosa of oral part of face - OBOL:automatic + OBOL:automatic mucosa of organ of oral opening - OBOL:automatic + OBOL:automatic mucosa of organ of oral part of face - OBOL:automatic + OBOL:automatic mucosa of organ of oral region - OBOL:automatic + OBOL:automatic mucosa of organ of subdivision of mouth - OBOL:automatic + OBOL:automatic mucosa of subdivision of mouth - OBOL:automatic + OBOL:automatic mucous membrane of oral opening - OBOL:automatic + OBOL:automatic mucous membrane of oral part of face - OBOL:automatic + OBOL:automatic mucous membrane of oral region - OBOL:automatic + OBOL:automatic mucous membrane of subdivision of mouth - OBOL:automatic + OBOL:automatic oral opening mucosa - OBOL:automatic + OBOL:automatic oral opening mucosa of organ - OBOL:automatic + OBOL:automatic oral opening mucous membrane - OBOL:automatic + OBOL:automatic oral opening organ mucosa - OBOL:automatic + OBOL:automatic oral part of face mucosa - OBOL:automatic + OBOL:automatic oral part of face mucosa of organ - OBOL:automatic + OBOL:automatic oral part of face mucous membrane - OBOL:automatic + OBOL:automatic oral part of face organ mucosa - OBOL:automatic + OBOL:automatic oral region mucosa - OBOL:automatic + OBOL:automatic oral region mucosa of organ - OBOL:automatic + OBOL:automatic oral region mucous membrane - OBOL:automatic + OBOL:automatic oral region organ mucosa - OBOL:automatic + OBOL:automatic organ mucosa of oral opening - OBOL:automatic + OBOL:automatic organ mucosa of oral part of face - OBOL:automatic + OBOL:automatic organ mucosa of oral region - OBOL:automatic + OBOL:automatic organ mucosa of subdivision of mouth - OBOL:automatic + OBOL:automatic subdivision of mouth mucosa - OBOL:automatic + OBOL:automatic subdivision of mouth mucosa of organ - OBOL:automatic + OBOL:automatic subdivision of mouth mucous membrane - OBOL:automatic + OBOL:automatic subdivision of mouth organ mucosa - OBOL:automatic + OBOL:automatic @@ -293115,11 +108784,11 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a rectum [Automatically generated definition]. + CALOHA:TS-2107 EMAPA:27081 FMA:15033 MA:0003218 - SCTID:362167003 mucosa of organ of rectum mucous membrane of rectum organ mucosa of rectum @@ -293137,25 +108806,25 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a rectum [Automatically generated definition]. - OBOL:automatic + OBOL:automatic mucosa of organ of rectum - OBOL:automatic + OBOL:automatic mucous membrane of rectum - OBOL:automatic + OBOL:automatic organ mucosa of rectum - OBOL:automatic + OBOL:automatic @@ -293173,25 +108842,25 @@ The modern definition of neurosecretion has evolved to include the release of an rectum mucosa - OBOL:automatic + OBOL:automatic rectum mucosa of organ - OBOL:automatic + OBOL:automatic rectum mucous membrane - OBOL:automatic + OBOL:automatic rectum organ mucosa - OBOL:automatic + OBOL:automatic @@ -293304,7 +108973,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -293315,46 +108984,46 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA An epithelium that is part of a pharynx [Automatically generated definition]. - OBOL:automatic + OBOL:automatic Epithelium lining the pharynx consisting largely of simple columnar epithelium with a short segment (1mm) of stratified squamous epithelium on the ventral side. Chen et al, 2007.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001174 - TAO - ZFIN:curator + TAO + ZFIN:curator epithelial tissue of pharynx - OBOL:automatic + OBOL:automatic epithelium of pharynx - OBOL:automatic + OBOL:automatic pharynx epithelial tissue - OBOL:automatic + OBOL:automatic pharynx epithelium - OBOL:automatic + OBOL:automatic @@ -293401,32 +109070,37 @@ The modern definition of neurosecretion has evolved to include the release of an - BTO + BTO An epithelium that is part of a midgut. - OBOL:automatic + OBOL:automatic epithelial tissue of midgut - OBOL:automatic + OBOL:automatic midgut epithelial tissue - OBOL:automatic + OBOL:automatic midgut epithelium BTO:0005053 - OBOL:automatic + + + + + midgut epithelium + OBOL:automatic @@ -293467,25 +109141,25 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a hindgut [Automatically generated definition]. - OBOL:automatic + OBOL:automatic epithelial tissue of hindgut - OBOL:automatic + OBOL:automatic hindgut epithelial tissue - OBOL:automatic + OBOL:automatic hindgut epithelium - OBOL:automatic + OBOL:automatic @@ -293531,13 +109205,13 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a rectum [Automatically generated definition]. - OBOL:automatic + OBOL:automatic epithelial tissue of rectum - OBOL:automatic + OBOL:automatic @@ -293549,13 +109223,13 @@ The modern definition of neurosecretion has evolved to include the release of an rectum epithelial tissue - OBOL:automatic + OBOL:automatic rectum epithelium - OBOL:automatic + OBOL:automatic @@ -293595,25 +109269,25 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a right lung [Automatically generated definition]. - OBOL:automatic + OBOL:automatic epithelial tissue of right lung - OBOL:automatic + OBOL:automatic right lung epithelial tissue - OBOL:automatic + OBOL:automatic right lung epithelium - OBOL:automatic + OBOL:automatic @@ -293653,25 +109327,25 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a left lung [Automatically generated definition]. - OBOL:automatic + OBOL:automatic epithelial tissue of left lung - OBOL:automatic + OBOL:automatic left lung epithelial tissue - OBOL:automatic + OBOL:automatic left lung epithelium - OBOL:automatic + OBOL:automatic @@ -293741,7 +109415,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -293752,13 +109426,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 An unilaminar epithelium that surrounds a pelvic appendage bud. - OBOL:automatic + OBOL:automatic @@ -293773,6 +109447,12 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:16780 + + + + hindlimb bud ectoderm + + @@ -293797,7 +109477,7 @@ The modern definition of neurosecretion has evolved to include the release of an leg ectoderm - OBOL:automatic + OBOL:automatic @@ -293868,7 +109548,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -293879,13 +109559,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 An unilaminar epithelium that surrounds a pectoral appendage bud. - OBOL:automatic + OBOL:automatic @@ -293894,6 +109574,12 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:16407 + + + + forelimb bud ectoderm + + @@ -293919,14 +109605,14 @@ The modern definition of neurosecretion has evolved to include the release of an wing ectoderm Geisha:syn - NCBITaxon:8782 + NCBITaxon:8782 arm ectoderm - OBOL:automatic + OBOL:automatic @@ -293953,11 +109639,10 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition]. - + EHDAA2:0004155 EMAPA:17326 FMA:7282 - SCTID:362018002 VHOG:0001227 cardiac muscle of cardiac right atrium cardiac muscle of heart right atrium @@ -293972,44 +109657,43 @@ The modern definition of neurosecretion has evolved to include the release of an textus muscularis of myocardium of right cardiac atrium uberon UBERON:0003379 - cardiac muscle of right atrium A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition]. - OBOL:automatic + OBOL:automatic cardiac muscle of cardiac right atrium - OBOL:automatic + OBOL:automatic cardiac muscle of heart right atrium - OBOL:automatic + OBOL:automatic cardiac muscle tissue of heart right atrium - OBOL:automatic + OBOL:automatic cardiac muscle tissue of right atrium - OBOL:automatic + OBOL:automatic cardiac muscle tissue of right atrium of heart - OBOL:automatic + OBOL:automatic @@ -294027,19 +109711,19 @@ The modern definition of neurosecretion has evolved to include the release of an textus muscularis of myocardium of right atrium - OBOL:automatic + OBOL:automatic textus muscularis of myocardium of right atrium of heart - OBOL:automatic + OBOL:automatic textus muscularis of myocardium of right cardiac atrium - OBOL:automatic + OBOL:automatic @@ -294066,10 +109750,10 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition]. + EHDAA2:0004154 EMAPA:17320 FMA:7285 - SCTID:189936008 VHOG:0001225 cardiac left atrium cardiac muscle cardiac left atrium cardiac muscle tissue @@ -294092,37 +109776,37 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition]. - OBOL:automatic + OBOL:automatic cardiac left atrium cardiac muscle - OBOL:automatic + OBOL:automatic cardiac left atrium cardiac muscle tissue - OBOL:automatic + OBOL:automatic cardiac muscle of cardiac left atrium - OBOL:automatic + OBOL:automatic cardiac muscle of heart left atrium - OBOL:automatic + OBOL:automatic cardiac muscle of left atrium of heart - OBOL:automatic + OBOL:automatic @@ -294140,31 +109824,31 @@ The modern definition of neurosecretion has evolved to include the release of an textus muscularis of myocardium of cardiac left atrium - OBOL:automatic + OBOL:automatic textus muscularis of myocardium of heart left atrium - OBOL:automatic + OBOL:automatic textus muscularis of myocardium of left atrium - OBOL:automatic + OBOL:automatic textus muscularis of myocardium of left atrium of heart - OBOL:automatic + OBOL:automatic textus muscularis of myocardium of left cardiac atrium - OBOL:automatic + OBOL:automatic @@ -294205,7 +109889,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -294264,7 +109948,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -294310,7 +109994,6 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition]. - EHDAA2:0004158 EMAPA:17335 FMA:84084 @@ -294323,14 +110006,13 @@ The modern definition of neurosecretion has evolved to include the release of an uberon interventricular septum muscle UBERON:0003383 - cardiac muscle tissue of interventricular septum A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -294360,7 +110042,7 @@ The modern definition of neurosecretion has evolved to include the release of an interventricular septum muscle - http://orcid.org/0000-0002-6601-2165 + @@ -294399,25 +110081,25 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition]. - OBOL:automatic + OBOL:automatic pharynx skeletal muscle - OBOL:automatic + OBOL:automatic pharynx skeletal muscle tissue - OBOL:automatic + OBOL:automatic skeletal muscle tissue of pharynx - OBOL:automatic + OBOL:automatic @@ -294464,7 +110146,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi. - MGI:cwg + MGI:cwg MP:0005247 @@ -294476,6 +110158,78 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition]. + + UBERON:0004244 + + BTO:0001391 + EMAPA:19192 + FMA:262010 + MA:0001863 + NCIT:C49306 + UMLS:C1710458 + trachea smooth muscle + tracheal smooth muscle + uberon + UBERON:0003387 + + + smooth muscle of trachea + + + + + A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C1710458 + ncithesaurus:Trachea_Smooth_Muscle_Tissue + + + + + trachea smooth muscle + MA:0001863 + + + + + tracheal smooth muscle + BTO:0001391 + + + + @@ -294514,49 +110268,49 @@ The modern definition of neurosecretion has evolved to include the release of an A mesothelium that is part of a pericardium [Automatically generated definition]. - OBOL:automatic + OBOL:automatic cavity of pericardial sac meso-epithelium - OBOL:automatic + OBOL:automatic cavity of pericardial sac mesothelium - OBOL:automatic + OBOL:automatic meso-epithelium of cavity of pericardial sac - OBOL:automatic + OBOL:automatic meso-epithelium of pericardial cavity - OBOL:automatic + OBOL:automatic mesothelium of cavity of pericardial sac - OBOL:automatic + OBOL:automatic pericardial cavity meso-epithelium - OBOL:automatic + OBOL:automatic pericardial cavity mesothelium - OBOL:automatic + OBOL:automatic @@ -294600,49 +110354,49 @@ The modern definition of neurosecretion has evolved to include the release of an A mesothelium that is part of a diaphragm [Automatically generated definition]. - OBOL:automatic + OBOL:automatic diaphragm meso-epithelium - OBOL:automatic + OBOL:automatic diaphragm mesothelium - OBOL:automatic + OBOL:automatic meso-epithelium of diaphragm - OBOL:automatic + OBOL:automatic meso-epithelium of thoracic diaphragm - OBOL:automatic + OBOL:automatic mesothelium of thoracic diaphragm - OBOL:automatic + OBOL:automatic thoracic diaphragm meso-epithelium - OBOL:automatic + OBOL:automatic thoracic diaphragm mesothelium - OBOL:automatic + OBOL:automatic @@ -294687,13 +110441,13 @@ The modern definition of neurosecretion has evolved to include the release of an A mesothelium that is part of a pleural cavity [Automatically generated definition]. - OBOL:automatic + OBOL:automatic meso-epithelium of pleural cavity - OBOL:automatic + OBOL:automatic @@ -294705,13 +110459,13 @@ The modern definition of neurosecretion has evolved to include the release of an pleural cavity meso-epithelium - OBOL:automatic + OBOL:automatic pleural cavity mesothelium - OBOL:automatic + OBOL:automatic @@ -294767,49 +110521,49 @@ The modern definition of neurosecretion has evolved to include the release of an A mesentery that is part of a urinary system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic excretory system mesentery - OBOL:automatic + OBOL:automatic mesentery of excretory system - OBOL:automatic + OBOL:automatic mesentery of renal system - OBOL:automatic + OBOL:automatic mesentery of systema urinaria - OBOL:automatic + OBOL:automatic renal system mesentery - OBOL:automatic + OBOL:automatic systema urinaria mesentery - OBOL:automatic + OBOL:automatic urinary system mesentery - OBOL:automatic + OBOL:automatic @@ -294846,13 +110600,13 @@ The modern definition of neurosecretion has evolved to include the release of an A mesentery that is part of a hindgut [Automatically generated definition]. - OBOL:automatic + OBOL:automatic hindgut mesentery - OBOL:automatic + OBOL:automatic @@ -294890,13 +110644,13 @@ The modern definition of neurosecretion has evolved to include the release of an A mesentery that is part of a rectum [Automatically generated definition]. - OBOL:automatic + OBOL:automatic rectum mesentery - OBOL:automatic + OBOL:automatic @@ -294925,9 +110679,9 @@ The modern definition of neurosecretion has evolved to include the release of an A mesentery that is part of a colon [Automatically generated definition]. + EMAPA:18942 FMA:14645 - SCTID:245457004 colon mesentery large bowel mesentery large intestinal mesentery @@ -294942,25 +110696,25 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A mesentery that is part of a colon [Automatically generated definition]. - OBOL:automatic + OBOL:automatic colon mesentery - OBOL:automatic + OBOL:automatic large bowel mesentery - OBOL:automatic + OBOL:automatic @@ -294972,7 +110726,7 @@ The modern definition of neurosecretion has evolved to include the release of an mesentery of large bowel - OBOL:automatic + OBOL:automatic @@ -294984,7 +110738,7 @@ The modern definition of neurosecretion has evolved to include the release of an mesocolon - https://github.com/obophenotype/uberon/issues/1473 + @@ -295022,13 +110776,13 @@ The modern definition of neurosecretion has evolved to include the release of an A mesentery that is part of a duodenum [Automatically generated definition]. - OBOL:automatic + OBOL:automatic duodenum mesentery - OBOL:automatic + OBOL:automatic @@ -295068,25 +110822,25 @@ The modern definition of neurosecretion has evolved to include the release of an A cartilage element that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic apparatus respiratorius cartilage - OBOL:automatic + OBOL:automatic cartilage of apparatus respiratorius - OBOL:automatic + OBOL:automatic respiratory system cartilage - OBOL:automatic + OBOL:automatic @@ -295105,6 +110859,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -295129,25 +110884,25 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that is part of a digestive tract [Automatically generated definition]. - OBOL:automatic + OBOL:automatic digestive tract gland - OBOL:automatic + OBOL:automatic gland of digestive tract - OBOL:automatic + OBOL:automatic gland of lower gastrointestinal tract - OBOL:automatic + OBOL:automatic @@ -295159,7 +110914,7 @@ The modern definition of neurosecretion has evolved to include the release of an lower gastrointestinal tract gland - OBOL:automatic + OBOL:automatic @@ -295210,22 +110965,22 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a pelvic appendage bud. - OBOL:automatic + OBOL:automatic Mesoderm part of pelvic fin bud.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001386 - TAO - ZFIN:curator + TAO + ZFIN:curator leg mesenchyme - OBOL:automatic + OBOL:automatic @@ -295305,22 +111060,22 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a pectoral appendage bud. - OBOL:automatic + OBOL:automatic Mesoderm that is part of the pectoral fin bud.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000789 - TAO - ZFIN:curator + TAO + ZFIN:curator arm mesenchyme - OBOL:automatic + OBOL:automatic @@ -295352,7 +111107,7 @@ The modern definition of neurosecretion has evolved to include the release of an wing mesenchyme - OBOL:automatic + OBOL:automatic @@ -295395,37 +111150,37 @@ The modern definition of neurosecretion has evolved to include the release of an An adipose tissue that is part of a dermis [Automatically generated definition]. - OBOL:automatic + OBOL:automatic adipose tissue of dermis - OBOL:automatic + OBOL:automatic dermis fat tissue - OBOL:automatic + OBOL:automatic dermis fatty tissue - OBOL:automatic + OBOL:automatic fat tissue of dermis - OBOL:automatic + OBOL:automatic fatty tissue of dermis - OBOL:automatic + OBOL:automatic @@ -295462,13 +111217,13 @@ The modern definition of neurosecretion has evolved to include the release of an A nerve that is part of an abdomen [Automatically generated definition]. - OBOL:automatic + OBOL:automatic nerve of abdomen - OBOL:automatic + OBOL:automatic @@ -295508,31 +111263,31 @@ The modern definition of neurosecretion has evolved to include the release of an A nerve that is part of a neck [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37263 - MA:th + MA:th neck (volume) nerve - OBOL:automatic + OBOL:automatic nerve of neck - OBOL:automatic + OBOL:automatic nerve of neck (volume) - OBOL:automatic + OBOL:automatic @@ -295572,13 +111327,13 @@ The modern definition of neurosecretion has evolved to include the release of an Any nerve that innervates the iris. - UBERON:cjm + UBERON:cjm nerve of iris - OBOL:automatic + OBOL:automatic @@ -295621,31 +111376,31 @@ The modern definition of neurosecretion has evolved to include the release of an A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk). - http://orcid.org/0000-0002-6601-2165 + EMAPA:37264 - MA:th + MA:th nerve of torso - OBOL:automatic + OBOL:automatic nerve of trunk - OBOL:automatic + OBOL:automatic torso nerve - OBOL:automatic + OBOL:automatic @@ -295698,67 +111453,67 @@ The modern definition of neurosecretion has evolved to include the release of an A nerve that is located in a thoracic cavity [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37267 - MA:th + MA:th cavity of chest nerve - OBOL:automatic + OBOL:automatic cavity of thorax nerve - OBOL:automatic + OBOL:automatic chest cavity nerve - OBOL:automatic + OBOL:automatic nerve of cavity of chest - OBOL:automatic + OBOL:automatic nerve of cavity of thorax - OBOL:automatic + OBOL:automatic nerve of chest cavity - OBOL:automatic + OBOL:automatic nerve of pectoral cavity - OBOL:automatic + OBOL:automatic nerve of thoracic cavity - OBOL:automatic + OBOL:automatic pectoral cavity nerve - OBOL:automatic + OBOL:automatic @@ -295796,359 +111551,19 @@ The modern definition of neurosecretion has evolved to include the release of an A nerve that is part of a pelvis [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37269 - MA:th + MA:th nerve of pelvis - OBOL:automatic - - - - - - - - - - - - - - - - - - - - - - - - - - A portion of cardiac muscle tissue that is part of a trabecula carnea [Automatically generated definition]. - EMAPA:36573 - FMA:84428 - MA:0002833 - cardiac muscle muscle tissue of trabecula carnea - cardiac muscle of trabecula carnea - cardiac muscle textus muscularis of trabecula carnea - cardiac muscle tissue of trabecula carnea - heart muscle muscle tissue of trabecula carnea - heart muscle textus muscularis of trabecula carnea - heart myocardium muscle tissue of trabecula carnea - heart myocardium textus muscularis of trabecula carnea - muscle of heart muscle tissue of trabecula carnea - muscle of heart textus muscularis of trabecula carnea - muscle tissue of cardiac muscle of trabecula carnea - muscle tissue of heart muscle of trabecula carnea - muscle tissue of heart myocardium of trabecula carnea - muscle tissue of muscle of heart of trabecula carnea - muscle tissue of myocardium of trabecula carnea - myocardium muscle tissue of trabecula carnea - myocardium textus muscularis of trabecula carnea - textus muscularis of cardiac muscle of trabecula carnea - textus muscularis of heart muscle of trabecula carnea - textus muscularis of heart myocardium of trabecula carnea - textus muscularis of muscle of heart of trabecula carnea - textus muscularis of myocardium of trabecula carnea - trabecula carnea cardiac muscle - trabecula carnea cardiac muscle muscle tissue - trabecula carnea cardiac muscle textus muscularis - trabecula carnea heart muscle muscle tissue - trabecula carnea heart muscle textus muscularis - trabecula carnea heart myocardium muscle tissue - trabecula carnea heart myocardium textus muscularis - trabecula carnea muscle of heart muscle tissue - trabecula carnea muscle of heart textus muscularis - trabecula carnea muscle tissue of cardiac muscle - trabecula carnea muscle tissue of heart muscle - trabecula carnea muscle tissue of heart myocardium - trabecula carnea muscle tissue of muscle of heart - trabecula carnea muscle tissue of myocardium - trabecula carnea myocardium muscle tissue - trabecula carnea myocardium textus muscularis - trabecula carnea textus muscularis of cardiac muscle - trabecula carnea textus muscularis of heart muscle - trabecula carnea textus muscularis of heart myocardium - trabecula carnea textus muscularis of muscle of heart - trabecula carnea textus muscularis of myocardium - uberon - UBERON:0003452 - - trabecula carnea cardiac muscle tissue - - - - - A portion of cardiac muscle tissue that is part of a trabecula carnea [Automatically generated definition]. - OBOL:automatic - - - - - cardiac muscle muscle tissue of trabecula carnea - OBOL:automatic - - - - - cardiac muscle of trabecula carnea - OBOL:automatic - - - - - cardiac muscle textus muscularis of trabecula carnea - OBOL:automatic - - - - - cardiac muscle tissue of trabecula carnea - OBOL:automatic - - - - - heart muscle muscle tissue of trabecula carnea - OBOL:automatic - - - - - heart muscle textus muscularis of trabecula carnea - OBOL:automatic - - - - - heart myocardium muscle tissue of trabecula carnea - OBOL:automatic - - - - - heart myocardium textus muscularis of trabecula carnea - OBOL:automatic - - - - - muscle of heart muscle tissue of trabecula carnea - OBOL:automatic - - - - - muscle of heart textus muscularis of trabecula carnea - OBOL:automatic - - - - - muscle tissue of cardiac muscle of trabecula carnea - OBOL:automatic - - - - - muscle tissue of heart muscle of trabecula carnea - OBOL:automatic - - - - - muscle tissue of heart myocardium of trabecula carnea - OBOL:automatic - - - - - muscle tissue of muscle of heart of trabecula carnea - OBOL:automatic - - - - - muscle tissue of myocardium of trabecula carnea - OBOL:automatic - - - - - myocardium muscle tissue of trabecula carnea - OBOL:automatic - - - - - myocardium textus muscularis of trabecula carnea - OBOL:automatic - - - - - textus muscularis of cardiac muscle of trabecula carnea - OBOL:automatic - - - - - textus muscularis of heart muscle of trabecula carnea - OBOL:automatic - - - - - textus muscularis of heart myocardium of trabecula carnea - OBOL:automatic - - - - - textus muscularis of muscle of heart of trabecula carnea - OBOL:automatic - - - - - textus muscularis of myocardium of trabecula carnea - OBOL:automatic - - - - - trabecula carnea cardiac muscle - OBOL:automatic - - - - - trabecula carnea cardiac muscle muscle tissue - OBOL:automatic - - - - - trabecula carnea cardiac muscle textus muscularis - OBOL:automatic - - - - - trabecula carnea heart muscle muscle tissue - OBOL:automatic - - - - - trabecula carnea heart muscle textus muscularis - OBOL:automatic - - - - - trabecula carnea heart myocardium muscle tissue - OBOL:automatic - - - - - trabecula carnea heart myocardium textus muscularis - OBOL:automatic - - - - - trabecula carnea muscle of heart muscle tissue - OBOL:automatic - - - - - trabecula carnea muscle of heart textus muscularis - OBOL:automatic - - - - - trabecula carnea muscle tissue of cardiac muscle - OBOL:automatic - - - - - trabecula carnea muscle tissue of heart muscle - OBOL:automatic - - - - - trabecula carnea muscle tissue of heart myocardium - OBOL:automatic - - - - - trabecula carnea muscle tissue of muscle of heart - OBOL:automatic - - - - - trabecula carnea muscle tissue of myocardium - OBOL:automatic - - - - - trabecula carnea myocardium muscle tissue - OBOL:automatic - - - - - trabecula carnea myocardium textus muscularis - OBOL:automatic - - - - - trabecula carnea textus muscularis of cardiac muscle - OBOL:automatic - - - - - trabecula carnea textus muscularis of heart muscle - OBOL:automatic - - - - - trabecula carnea textus muscularis of heart myocardium - OBOL:automatic - - - - - trabecula carnea textus muscularis of muscle of heart - OBOL:automatic - - - - - trabecula carnea textus muscularis of myocardium - OBOL:automatic + OBOL:automatic @@ -296175,9 +111590,9 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a head [Automatically generated definition]. + EMAPA:35996 MA:0000576 - SCTID:118646007 adult head bone adult head bone organ bone of adult head @@ -296196,55 +111611,55 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a head [Automatically generated definition]. - OBOL:automatic + OBOL:automatic adult head bone - OBOL:automatic + OBOL:automatic adult head bone organ - OBOL:automatic + OBOL:automatic bone of adult head - OBOL:automatic + OBOL:automatic bone of head - OBOL:automatic + OBOL:automatic bone organ of adult head - OBOL:automatic + OBOL:automatic bone organ of head - OBOL:automatic + OBOL:automatic head bone organ - OBOL:automatic + OBOL:automatic craniofacial bone - http://orcid.org/0000-0002-6601-2165 + @@ -296263,7 +111678,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -296273,6 +111688,7 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a neck [Automatically generated definition]. EMAPA:37246 MA:0000584 + OpenCyc:Mx4rvnpJSJwpEbGdrcN5Y29ycA bone of neck bone of neck (volume) bone organ of neck @@ -296288,55 +111704,55 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a neck [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37246 - MA:th + MA:th bone of neck - OBOL:automatic + OBOL:automatic bone of neck (volume) - OBOL:automatic + OBOL:automatic bone organ of neck - OBOL:automatic + OBOL:automatic bone organ of neck (volume) - OBOL:automatic + OBOL:automatic neck (volume) bone - OBOL:automatic + OBOL:automatic neck (volume) bone organ - OBOL:automatic + OBOL:automatic neck bone organ - OBOL:automatic + OBOL:automatic @@ -296365,13 +111781,14 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a facial skeleton [Automatically generated definition]. test whether 'facial bone' is an exact synonym + + EMAPA:19019 EMAPA:35924 MA:0001482 MA:0003159 MESH:D005147 NCIT:C63706 - SCTID:181799005 UMLS:C0015455 bone of facial skeleton facial bone @@ -296392,13 +111809,13 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA A bone that is part of a facial skeleton [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -296410,7 +111827,7 @@ The modern definition of neurosecretion has evolved to include the release of an bone of facial skeleton - OBOL:automatic + OBOL:automatic @@ -296422,19 +111839,19 @@ The modern definition of neurosecretion has evolved to include the release of an facial skeleton bone - OBOL:automatic + OBOL:automatic bone of viscerocranium - OBOL:automatic + OBOL:automatic viscerocranium bone - OBOL:automatic + OBOL:automatic @@ -296462,9 +111879,9 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a trunk [Automatically generated definition]. + EMAPA:36583 MA:0000512 - SCTID:427358002 bone of torso bone of trunk bone organ of torso @@ -296480,49 +111897,49 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a trunk [Automatically generated definition]. - OBOL:automatic + OBOL:automatic bone of torso - OBOL:automatic + OBOL:automatic bone of trunk - OBOL:automatic + OBOL:automatic bone organ of torso - OBOL:automatic + OBOL:automatic bone organ of trunk - OBOL:automatic + OBOL:automatic torso bone - OBOL:automatic + OBOL:automatic torso bone organ - OBOL:automatic + OBOL:automatic trunk bone organ - OBOL:automatic + OBOL:automatic @@ -296560,13 +111977,13 @@ The modern definition of neurosecretion has evolved to include the release of an An artery that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37569 - MA:th + MA:th @@ -296586,13 +112003,21 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + @@ -296601,17 +112026,17 @@ The modern definition of neurosecretion has evolved to include the release of an - + The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose. + + EMAPA:37430 FMA:49570 MA:0001917 - SCTID:145137009 - Wikipedia:Superior_labial_artery arteria labialis superior ramus labialis superior arteriae facialis superior labial artery @@ -296626,36 +112051,36 @@ The modern definition of neurosecretion has evolved to include the release of an - + - FMA + FMA The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose. - Wikipedia:Superior_labial_artery + EMAPA:37430 - MA:th + MA:th arteria labialis superior - Wikipedia:Superior_labial_artery + ramus labialis superior arteriae facialis - Wikipedia:Superior_labial_artery + @@ -296688,13 +112113,21 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + @@ -296703,17 +112136,17 @@ The modern definition of neurosecretion has evolved to include the release of an - + The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery. + + EMAPA:37429 FMA:49567 MA:0001916 - SCTID:145036002 - Wikipedia:Inferior_labial_artery arteria labialis inferior inferior labial artery inferior labial branch of facial artery @@ -296729,29 +112162,29 @@ The modern definition of neurosecretion has evolved to include the release of an - + - FMA + FMA The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery. - Wikipedia:Inferior_labial_artery + EMAPA:37429 - MA:th + MA:th arteria labialis inferior - Wikipedia:Inferior_labial_artery + @@ -296770,13 +112203,13 @@ The modern definition of neurosecretion has evolved to include the release of an ramus labialis inferior (arteria facialis) - FMA:TA + FMA:TA ramus labialis inferior arteriae facialis - Wikipedia:Inferior_labial_artery + @@ -296818,19 +112251,19 @@ The modern definition of neurosecretion has evolved to include the release of an An artery that is part of a thoracic cavity[cjm]. - https://sourceforge.net/tracker/index.php?func=detail&aid=3317815&group_id=76834&atid=1205376 + in MA, aorta is classified here - but this is problematic because the abdominal aorta is not in the thoracic cavity - MA + MA EMAPA:37241 - MA:th + MA:th @@ -296884,37 +112317,37 @@ The modern definition of neurosecretion has evolved to include the release of an A vein that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37584 - MA:th + MA:th apparatus respiratorius vein - OBOL:automatic + OBOL:automatic respiratory system vein - OBOL:automatic + OBOL:automatic vein of apparatus respiratorius - OBOL:automatic + OBOL:automatic vein of respiratory system - OBOL:automatic + OBOL:automatic @@ -296948,11 +112381,11 @@ The modern definition of neurosecretion has evolved to include the release of an The inferior labial vein is the vein receiving blood from the upper lip. + + EMAPA:37204 FMA:52538 MA:0002255 - SCTID:422755007 - Wikipedia:Superior_labial_vein superior labial vein upper lip vein vena labialis superior @@ -296970,19 +112403,19 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The inferior labial vein is the vein receiving blood from the upper lip. - Wikipedia:Superior_labial_vein + EMAPA:37204 - MA:th + MA:th @@ -296994,7 +112427,7 @@ The modern definition of neurosecretion has evolved to include the release of an upper lip vein - OBOL:automatic + OBOL:automatic @@ -297034,11 +112467,11 @@ The modern definition of neurosecretion has evolved to include the release of an The inferior labial vein is the vein receiving blood from the lower lip. + + EMAPA:37202 FMA:52541 MA:0002253 - SCTID:422955002 - Wikipedia:Inferior_labial_vein inferior labial vein lower lip vein vena labialis inferior @@ -297047,7 +112480,7 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0003478 vein of lower lip - http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png + http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png @@ -297058,19 +112491,19 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The inferior labial vein is the vein receiving blood from the lower lip. - Wikipedia:Inferior_labial_vein + EMAPA:37202 - MA:th + MA:th @@ -297082,7 +112515,7 @@ The modern definition of neurosecretion has evolved to include the release of an lower lip vein - OBOL:automatic + OBOL:automatic @@ -297094,7 +112527,7 @@ The modern definition of neurosecretion has evolved to include the release of an venae labiales inferiores - Wikipedia:Inferior_labial_vein + @@ -297142,67 +112575,67 @@ The modern definition of neurosecretion has evolved to include the release of an A vein that is part of a thoracic cavity [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37242 - MA:th + MA:th cavity of chest vein - OBOL:automatic + OBOL:automatic cavity of thorax vein - OBOL:automatic + OBOL:automatic chest cavity vein - OBOL:automatic + OBOL:automatic pectoral cavity vein - OBOL:automatic + OBOL:automatic vein of cavity of chest - OBOL:automatic + OBOL:automatic vein of cavity of thorax - OBOL:automatic + OBOL:automatic vein of chest cavity - OBOL:automatic + OBOL:automatic vein of pectoral cavity - OBOL:automatic + OBOL:automatic vein of thoracic cavity - OBOL:automatic + OBOL:automatic @@ -297231,10 +112664,10 @@ The modern definition of neurosecretion has evolved to include the release of an A vein that is part of a tail [Automatically generated definition]. see also caudal vein + AAO:0011105 EMAPA:37761 MA:0002233 - Wikipedia:Tail_vein XAO:0000393 post-vent region vein vein of post-vent region @@ -297248,38 +112681,38 @@ The modern definition of neurosecretion has evolved to include the release of an A vein that is part of a tail [Automatically generated definition]. - OBOL:automatic - Wikipedia:Tail_vein + + OBOL:automatic EMAPA:37761 - MA:th + MA:th post-vent region vein - OBOL:automatic + OBOL:automatic vein of post-vent region - OBOL:automatic + OBOL:automatic vein of tail - OBOL:automatic + OBOL:automatic caudal vein - Wikipedia:Tail_vein + @@ -297357,7 +112790,7 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + @@ -297368,158 +112801,158 @@ The modern definition of neurosecretion has evolved to include the release of an - true - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + true + An endothelium of capillary that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37575 - MA:th + MA:th apparatus respiratorius blood capillary endothelium - OBOL:automatic + OBOL:automatic apparatus respiratorius capillary endothelium - OBOL:automatic + OBOL:automatic apparatus respiratorius capillary vessel endothelium - OBOL:automatic + OBOL:automatic apparatus respiratorius endothelium of blood capillary - OBOL:automatic + OBOL:automatic apparatus respiratorius endothelium of capillary - OBOL:automatic + OBOL:automatic apparatus respiratorius endothelium of capillary vessel - OBOL:automatic + OBOL:automatic blood capillary endothelium of apparatus respiratorius - OBOL:automatic + OBOL:automatic blood capillary endothelium of respiratory system - OBOL:automatic + OBOL:automatic capillary endothelium of apparatus respiratorius - OBOL:automatic + OBOL:automatic capillary endothelium of respiratory system - OBOL:automatic + OBOL:automatic capillary vessel endothelium of apparatus respiratorius - OBOL:automatic + OBOL:automatic capillary vessel endothelium of respiratory system - OBOL:automatic + OBOL:automatic endothelium of blood capillary of apparatus respiratorius - OBOL:automatic + OBOL:automatic endothelium of blood capillary of respiratory system - OBOL:automatic + OBOL:automatic endothelium of capillary of apparatus respiratorius - OBOL:automatic + OBOL:automatic endothelium of capillary of respiratory system - OBOL:automatic + OBOL:automatic endothelium of capillary vessel of apparatus respiratorius - OBOL:automatic + OBOL:automatic endothelium of capillary vessel of respiratory system - OBOL:automatic + OBOL:automatic respiratory system blood capillary endothelium - OBOL:automatic + OBOL:automatic respiratory system capillary vessel endothelium - OBOL:automatic + OBOL:automatic respiratory system endothelium of blood capillary - OBOL:automatic + OBOL:automatic respiratory system endothelium of capillary - OBOL:automatic + OBOL:automatic respiratory system endothelium of capillary vessel - OBOL:automatic + OBOL:automatic @@ -297560,31 +112993,31 @@ The modern definition of neurosecretion has evolved to include the release of an A venule that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37587 - MA:th + MA:th apparatus respiratorius venule - OBOL:automatic + OBOL:automatic venule of apparatus respiratorius - OBOL:automatic + OBOL:automatic venule of respiratory system - OBOL:automatic + OBOL:automatic @@ -297633,20 +113066,20 @@ The modern definition of neurosecretion has evolved to include the release of an - true - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + true + An arteriole that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37568 - MA:th + MA:th @@ -297679,9 +113112,9 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a head [Automatically generated definition]. + EMAPA:36610 MA:0000575 - SCTID:127865000 adult head blood vessel blood vessel of adult head blood vessel of head @@ -297698,32 +113131,32 @@ The modern definition of neurosecretion has evolved to include the release of an - true - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + true + A blood vessel that is part of a head [Automatically generated definition]. - OBOL:automatic + OBOL:automatic adult head blood vessel - OBOL:automatic + OBOL:automatic blood vessel of adult head - OBOL:automatic + OBOL:automatic blood vessel of head - OBOL:automatic + OBOL:automatic @@ -297761,13 +113194,13 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of an abdomen [Automatically generated definition]. - OBOL:automatic + OBOL:automatic blood vessel of abdomen - OBOL:automatic + OBOL:automatic @@ -297820,13 +113253,13 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a heart [Automatically generated definition]. - OBOL:automatic + OBOL:automatic blood vessel of heart - OBOL:automatic + OBOL:automatic @@ -297878,13 +113311,13 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a brain [Automatically generated definition]. - OBOL:automatic + OBOL:automatic blood vessel of brain - OBOL:automatic + OBOL:automatic @@ -297926,26 +113359,26 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a cornea [Automatically generated definition]. - https://orcid.org/0000-0002-6601-2165 - https://sourceforge.net/tracker/index.php?func=detail&aid=3564332&group_id=36855&atid=440764 + + - PMID:17051153 + blood vessel of cornea - OBOL:automatic + OBOL:automatic cornea blood vessel - OBOL:automatic + OBOL:automatic @@ -297985,11 +113418,11 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a retina [Automatically generated definition]. + EMAPA:36520 GAID:509 MA:0001317 MESH:D012171 - SCTID:280692003 XAO:0004153 blood vessel of inner layer of eyeball blood vessel of retina @@ -298006,43 +113439,43 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a retina [Automatically generated definition]. - OBOL:automatic + OBOL:automatic blood vessel of inner layer of eyeball - OBOL:automatic + OBOL:automatic blood vessel of retina - OBOL:automatic + OBOL:automatic blood vessel of tunica interna of eyeball - OBOL:automatic + OBOL:automatic inner layer of eyeball blood vessel - OBOL:automatic + OBOL:automatic retinal blood vessel - OBOL:automatic + OBOL:automatic tunica interna of eyeball blood vessel - OBOL:automatic + OBOL:automatic @@ -298082,31 +113515,31 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a neck [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37236 - MA:th + MA:th blood vessel of neck - OBOL:automatic + OBOL:automatic blood vessel of neck (volume) - OBOL:automatic + OBOL:automatic neck (volume) blood vessel - OBOL:automatic + OBOL:automatic @@ -298147,25 +113580,73 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic apparatus respiratorius blood vessel - OBOL:automatic + OBOL:automatic blood vessel of apparatus respiratorius - OBOL:automatic + OBOL:automatic blood vessel of respiratory system - OBOL:automatic + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a trachea. + + UBERON:0003525 + EMAPA:35874 + MA:0001852 + blood vessel of trachea + uberon + UBERON:0003505 + + trachea blood vessel + + + + + A blood vessel that is part of a trachea. + OBOL:automatic + + + + + blood vessel of trachea + OBOL:automatic @@ -298204,7 +113685,7 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta. - https://orcid.org/0000-0002-6601-2165 + @@ -298251,19 +113732,19 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a iris [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37387 - MA:th + MA:th blood vessel of iris - OBOL:automatic + OBOL:automatic @@ -298311,13 +113792,13 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a lung [Automatically generated definition]. - OBOL:automatic + OBOL:automatic blood vessel of lung - OBOL:automatic + OBOL:automatic @@ -298363,31 +113844,31 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a trunk [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37237 - MA:th + MA:th blood vessel of torso - OBOL:automatic + OBOL:automatic blood vessel of trunk - OBOL:automatic + OBOL:automatic torso blood vessel - OBOL:automatic + OBOL:automatic @@ -298433,67 +113914,67 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a thoracic cavity [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37240 - MA:th + MA:th blood vessel of cavity of chest - OBOL:automatic + OBOL:automatic blood vessel of cavity of thorax - OBOL:automatic + OBOL:automatic blood vessel of chest cavity - OBOL:automatic + OBOL:automatic blood vessel of pectoral cavity - OBOL:automatic + OBOL:automatic blood vessel of thoracic cavity - OBOL:automatic + OBOL:automatic cavity of chest blood vessel - OBOL:automatic + OBOL:automatic cavity of thorax blood vessel - OBOL:automatic + OBOL:automatic chest cavity blood vessel - OBOL:automatic + OBOL:automatic pectoral cavity blood vessel - OBOL:automatic + OBOL:automatic @@ -298531,19 +114012,19 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a pelvis [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37244 - MA:th + MA:th blood vessel of pelvis - OBOL:automatic + OBOL:automatic @@ -298583,25 +114064,25 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a tail [Automatically generated definition]. - OBOL:automatic + OBOL:automatic blood vessel of post-vent region - OBOL:automatic + OBOL:automatic blood vessel of tail - OBOL:automatic + OBOL:automatic post-vent region blood vessel - OBOL:automatic + OBOL:automatic @@ -298650,79 +114131,79 @@ The modern definition of neurosecretion has evolved to include the release of an A capillary that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37574 - MA:th + MA:th apparatus respiratorius blood capillary - OBOL:automatic + OBOL:automatic apparatus respiratorius capillary - OBOL:automatic + OBOL:automatic apparatus respiratorius capillary vessel - OBOL:automatic + OBOL:automatic blood capillary of apparatus respiratorius - OBOL:automatic + OBOL:automatic blood capillary of respiratory system - OBOL:automatic + OBOL:automatic capillary of apparatus respiratorius - OBOL:automatic + OBOL:automatic capillary of respiratory system - OBOL:automatic + OBOL:automatic capillary vessel of apparatus respiratorius - OBOL:automatic + OBOL:automatic capillary vessel of respiratory system - OBOL:automatic + OBOL:automatic respiratory system blood capillary - OBOL:automatic + OBOL:automatic respiratory system capillary vessel - OBOL:automatic + OBOL:automatic @@ -298749,6 +114230,7 @@ The modern definition of neurosecretion has evolved to include the release of an A gray matter that is part of a brain [Automatically generated definition]. + EMAPA:35184 MA:0000810 NCIT:C49333 @@ -298766,7 +114248,7 @@ The modern definition of neurosecretion has evolved to include the release of an A gray matter that is part of a brain [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -298784,25 +114266,25 @@ The modern definition of neurosecretion has evolved to include the release of an brain grey substance - OBOL:automatic + OBOL:automatic gray matter of brain - OBOL:automatic + OBOL:automatic grey matter of brain - OBOL:automatic + OBOL:automatic grey substance of brain - OBOL:automatic + OBOL:automatic @@ -298829,9 +114311,9 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a tail [Automatically generated definition]. + EMAPA:36502 MA:0000700 - SCTID:67214004 post-vent region skin skin of post-vent region skin of tail @@ -298844,25 +114326,297 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a tail [Automatically generated definition]. - OBOL:automatic + OBOL:automatic post-vent region skin - OBOL:automatic + OBOL:automatic skin of post-vent region - OBOL:automatic + OBOL:automatic skin of tail - OBOL:automatic + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A bronchiole that is part of a right lung [Automatically generated definition]. + + + EMAPA:35425 + MA:0001787 + NCIT:C49279 + UMLS:C0225670 + bronchiole of right lung + lobular bronchiole of right lung + right lung lobular bronchiole + uberon + UBERON:0003538 + right lung bronchiole + + + + + A bronchiole that is part of a right lung [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C0225670 + ncithesaurus:Right_Lung_Bronchiole + + + + + bronchiole of right lung + OBOL:automatic + + + + + lobular bronchiole of right lung + OBOL:automatic + + + + + right lung lobular bronchiole + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A bronchiole that is part of a left lung [Automatically generated definition]. + + + EMAPA:19000 + MA:0001778 + NCIT:C49252 + UMLS:C0225674 + bronchiole of left lung + left lung lobular bronchiole + lobular bronchiole of left lung + uberon + UBERON:0003539 + left lung bronchiole + + + + + A bronchiole that is part of a left lung [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C0225674 + ncithesaurus:Left_Lung_Bronchiole + + + + + bronchiole of left lung + OBOL:automatic + + + + + left lung lobular bronchiole + OBOL:automatic + + + + + lobular bronchiole of left lung + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A terminal bronchiole that is part of a right lung [Automatically generated definition]. + + EMAPA:36638 + MA:0001789 + NCIT:C49294 + UMLS:C1709961 + bronchiolus terminalis of right lung + right lung bronchiolus terminalis + terminal bronchiole of right lung + uberon + UBERON:0003540 + right lung terminal bronchiole + + + + + A terminal bronchiole that is part of a right lung [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C1709961 + ncithesaurus:Right_Lung_Terminal_Bronchiole + + + + + bronchiolus terminalis of right lung + OBOL:automatic + + + + + right lung bronchiolus terminalis + OBOL:automatic + + + + + terminal bronchiole of right lung + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A terminal bronchiole that is part of a left lung [Automatically generated definition]. + + EMAPA:36636 + MA:0001780 + NCIT:C49255 + UMLS:C1708675 + bronchiolus terminalis of left lung + left lung bronchiolus terminalis + terminal bronchiole of left lung + uberon + UBERON:0003541 + left lung terminal bronchiole + + + + + A terminal bronchiole that is part of a left lung [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C1708675 + ncithesaurus:Left_Lung_Terminal_Bronchiole + + + + + bronchiolus terminalis of left lung + OBOL:automatic + + + + + left lung bronchiolus terminalis + OBOL:automatic + + + + + terminal bronchiole of left lung + OBOL:automatic @@ -298881,6 +114635,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -298922,73 +114677,73 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of connective tissue that is part of a head [Automatically generated definition]. - OBOL:automatic + OBOL:automatic adult head connective tissue - OBOL:automatic + OBOL:automatic adult head portion of connective tissue - OBOL:automatic + OBOL:automatic adult head textus connectivus - OBOL:automatic + OBOL:automatic connective tissue of adult head - OBOL:automatic + OBOL:automatic connective tissue of head - OBOL:automatic + OBOL:automatic head portion of connective tissue - OBOL:automatic + OBOL:automatic head textus connectivus - OBOL:automatic + OBOL:automatic portion of connective tissue of adult head - OBOL:automatic + OBOL:automatic portion of connective tissue of head - OBOL:automatic + OBOL:automatic textus connectivus of adult head - OBOL:automatic + OBOL:automatic textus connectivus of head - OBOL:automatic + OBOL:automatic @@ -299029,37 +114784,37 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of connective tissue that is part of an abdomen [Automatically generated definition]. - OBOL:automatic + OBOL:automatic abdomen portion of connective tissue - OBOL:automatic + OBOL:automatic abdomen textus connectivus - OBOL:automatic + OBOL:automatic connective tissue of abdomen - OBOL:automatic + OBOL:automatic portion of connective tissue of abdomen - OBOL:automatic + OBOL:automatic textus connectivus of abdomen - OBOL:automatic + OBOL:automatic @@ -299107,79 +114862,79 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of connective tissue that is part of a neck [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37250 - MA:th + MA:th connective tissue of neck - OBOL:automatic + OBOL:automatic connective tissue of neck (volume) - OBOL:automatic + OBOL:automatic neck (volume) connective tissue - OBOL:automatic + OBOL:automatic neck (volume) portion of connective tissue - OBOL:automatic + OBOL:automatic neck (volume) textus connectivus - OBOL:automatic + OBOL:automatic neck portion of connective tissue - OBOL:automatic + OBOL:automatic neck textus connectivus - OBOL:automatic + OBOL:automatic portion of connective tissue of neck - OBOL:automatic + OBOL:automatic portion of connective tissue of neck (volume) - OBOL:automatic + OBOL:automatic textus connectivus of neck - OBOL:automatic + OBOL:automatic textus connectivus of neck (volume) - OBOL:automatic + OBOL:automatic @@ -299228,73 +114983,139 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of connective tissue that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic apparatus respiratorius connective tissue - OBOL:automatic + OBOL:automatic apparatus respiratorius portion of connective tissue - OBOL:automatic + OBOL:automatic apparatus respiratorius textus connectivus - OBOL:automatic + OBOL:automatic connective tissue of apparatus respiratorius - OBOL:automatic + OBOL:automatic connective tissue of respiratory system - OBOL:automatic + OBOL:automatic portion of connective tissue of apparatus respiratorius - OBOL:automatic + OBOL:automatic portion of connective tissue of respiratory system - OBOL:automatic + OBOL:automatic respiratory system portion of connective tissue - OBOL:automatic + OBOL:automatic respiratory system textus connectivus - OBOL:automatic + OBOL:automatic textus connectivus of apparatus respiratorius - OBOL:automatic + OBOL:automatic textus connectivus of respiratory system - OBOL:automatic + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of connective tissue that is part of a trachea. + + EMAPA:35876 + MA:0001853 + connective tissue of trachea + connective tissue of windpipe + uberon + UBERON:0003571 + + trachea connective tissue + + + + + A portion of connective tissue that is part of a trachea. + OBOL:automatic + + + + + connective tissue of trachea + OBOL:automatic + + + + + connective tissue of windpipe + OBOL:automatic @@ -299337,43 +115158,43 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37548 - MA:th + MA:th connective tissue of lower respiratory tract - OBOL:automatic + OBOL:automatic lower respiratory tract portion of connective tissue - OBOL:automatic + OBOL:automatic lower respiratory tract textus connectivus - OBOL:automatic + OBOL:automatic portion of connective tissue of lower respiratory tract - OBOL:automatic + OBOL:automatic textus connectivus of lower respiratory tract - OBOL:automatic + OBOL:automatic @@ -299434,43 +115255,43 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/The-neural-crest + A portion of connective tissue that is part of a dermis [Automatically generated definition]. - OBOL:automatic + OBOL:automatic connective tissue of dermis - OBOL:automatic + OBOL:automatic dermis portion of connective tissue - OBOL:automatic + OBOL:automatic dermis textus connectivus - OBOL:automatic + OBOL:automatic portion of connective tissue of dermis - OBOL:automatic + OBOL:automatic textus connectivus of dermis - OBOL:automatic + OBOL:automatic @@ -299518,79 +115339,261 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of connective tissue that is part of a trunk [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37252 - MA:th + MA:th connective tissue of torso - OBOL:automatic + OBOL:automatic connective tissue of trunk - OBOL:automatic + OBOL:automatic portion of connective tissue of torso - OBOL:automatic + OBOL:automatic portion of connective tissue of trunk - OBOL:automatic + OBOL:automatic textus connectivus of torso - OBOL:automatic + OBOL:automatic textus connectivus of trunk - OBOL:automatic + OBOL:automatic torso connective tissue - OBOL:automatic + OBOL:automatic torso portion of connective tissue - OBOL:automatic + OBOL:automatic torso textus connectivus - OBOL:automatic + OBOL:automatic trunk portion of connective tissue - OBOL:automatic + OBOL:automatic trunk textus connectivus - OBOL:automatic + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of connective tissue that is part of a bronchus [Automatically generated definition]. + + + EMAPA:32690 + EMAPA:35193 + MA:0001831 + NCIT:C49210 + UMLS:C1707052 + bronchi connective tissue + bronchi portion of connective tissue + bronchi textus connectivus + bronchial trunk connective tissue + bronchial trunk portion of connective tissue + bronchial trunk textus connectivus + bronchus portion of connective tissue + bronchus textus connectivus + connective tissue of bronchi + connective tissue of bronchial trunk + connective tissue of bronchus + portion of connective tissue of bronchi + portion of connective tissue of bronchial trunk + portion of connective tissue of bronchus + textus connectivus of bronchi + textus connectivus of bronchial trunk + textus connectivus of bronchus + uberon + bronchial connective tissue + bronchial mesenchyme + UBERON:0003592 + + bronchus connective tissue + + + + + A portion of connective tissue that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C1707052 + ncithesaurus:Bronchus_Connective_Tissue + + + + + bronchi connective tissue + OBOL:automatic + + + + + bronchi portion of connective tissue + OBOL:automatic + + + + + bronchi textus connectivus + OBOL:automatic + + + + + bronchial trunk connective tissue + OBOL:automatic + + + + + bronchial trunk portion of connective tissue + OBOL:automatic + + + + + bronchial trunk textus connectivus + OBOL:automatic + + + + + bronchus portion of connective tissue + OBOL:automatic + + + + + bronchus textus connectivus + OBOL:automatic + + + + + connective tissue of bronchi + OBOL:automatic + + + + + connective tissue of bronchial trunk + OBOL:automatic + + + + + connective tissue of bronchus + OBOL:automatic + + + + + portion of connective tissue of bronchi + OBOL:automatic + + + + + portion of connective tissue of bronchial trunk + OBOL:automatic + + + + + portion of connective tissue of bronchus + OBOL:automatic + + + + + textus connectivus of bronchi + OBOL:automatic + + + + + textus connectivus of bronchial trunk + OBOL:automatic + + + + + textus connectivus of bronchus + OBOL:automatic + + + + + bronchial connective tissue + EMAPA:35193 + + + + + bronchial mesenchyme + EMAPA:32690 @@ -299656,187 +115659,187 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37255 - MA:th + MA:th cavity of chest connective tissue - OBOL:automatic + OBOL:automatic cavity of chest portion of connective tissue - OBOL:automatic + OBOL:automatic cavity of chest textus connectivus - OBOL:automatic + OBOL:automatic cavity of thorax connective tissue - OBOL:automatic + OBOL:automatic cavity of thorax portion of connective tissue - OBOL:automatic + OBOL:automatic cavity of thorax textus connectivus - OBOL:automatic + OBOL:automatic chest cavity connective tissue - OBOL:automatic + OBOL:automatic chest cavity portion of connective tissue - OBOL:automatic + OBOL:automatic chest cavity textus connectivus - OBOL:automatic + OBOL:automatic connective tissue of cavity of chest - OBOL:automatic + OBOL:automatic connective tissue of cavity of thorax - OBOL:automatic + OBOL:automatic connective tissue of chest cavity - OBOL:automatic + OBOL:automatic connective tissue of pectoral cavity - OBOL:automatic + OBOL:automatic connective tissue of thoracic cavity - OBOL:automatic + OBOL:automatic pectoral cavity connective tissue - OBOL:automatic + OBOL:automatic pectoral cavity portion of connective tissue - OBOL:automatic + OBOL:automatic pectoral cavity textus connectivus - OBOL:automatic + OBOL:automatic portion of connective tissue of cavity of chest - OBOL:automatic + OBOL:automatic portion of connective tissue of cavity of thorax - OBOL:automatic + OBOL:automatic portion of connective tissue of chest cavity - OBOL:automatic + OBOL:automatic portion of connective tissue of pectoral cavity - OBOL:automatic + OBOL:automatic portion of connective tissue of thoracic cavity - OBOL:automatic + OBOL:automatic textus connectivus of cavity of chest - OBOL:automatic + OBOL:automatic textus connectivus of cavity of thorax - OBOL:automatic + OBOL:automatic textus connectivus of chest cavity - OBOL:automatic + OBOL:automatic textus connectivus of pectoral cavity - OBOL:automatic + OBOL:automatic textus connectivus of thoracic cavity - OBOL:automatic + OBOL:automatic thoracic cavity portion of connective tissue - OBOL:automatic + OBOL:automatic thoracic cavity textus connectivus - OBOL:automatic + OBOL:automatic @@ -299878,43 +115881,43 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of connective tissue that is part of a pelvis [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37257 - MA:th + MA:th connective tissue of pelvis - OBOL:automatic + OBOL:automatic pelvis portion of connective tissue - OBOL:automatic + OBOL:automatic pelvis textus connectivus - OBOL:automatic + OBOL:automatic portion of connective tissue of pelvis - OBOL:automatic + OBOL:automatic textus connectivus of pelvis - OBOL:automatic + OBOL:automatic @@ -299933,6 +115936,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -299962,73 +115966,73 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of connective tissue that is part of a tail [Automatically generated definition]. - OBOL:automatic + OBOL:automatic connective tissue of post-vent region - OBOL:automatic + OBOL:automatic connective tissue of tail - OBOL:automatic + OBOL:automatic portion of connective tissue of post-vent region - OBOL:automatic + OBOL:automatic portion of connective tissue of tail - OBOL:automatic + OBOL:automatic post-vent region connective tissue - OBOL:automatic + OBOL:automatic post-vent region portion of connective tissue - OBOL:automatic + OBOL:automatic post-vent region textus connectivus - OBOL:automatic + OBOL:automatic tail portion of connective tissue - OBOL:automatic + OBOL:automatic tail textus connectivus - OBOL:automatic + OBOL:automatic textus connectivus of post-vent region - OBOL:automatic + OBOL:automatic textus connectivus of tail - OBOL:automatic + OBOL:automatic @@ -300068,31 +116072,31 @@ The modern definition of neurosecretion has evolved to include the release of an A cartilage that is part of a neck [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37251 - MA:th + MA:th cartilage of neck - OBOL:automatic + OBOL:automatic cartilage of neck (volume) - OBOL:automatic + OBOL:automatic neck (volume) cartilage - OBOL:automatic + OBOL:automatic @@ -300120,6 +116124,7 @@ The modern definition of neurosecretion has evolved to include the release of an A cartilage that is part of a lower respiratory tract [Automatically generated definition]. + EMAPA:37547 MA:0001819 NCIT:C49256 @@ -300133,13 +116138,13 @@ The modern definition of neurosecretion has evolved to include the release of an A cartilage that is part of a lower respiratory tract [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37547 - MA:th + MA:th @@ -300151,7 +116156,152 @@ The modern definition of neurosecretion has evolved to include the release of an cartilage of lower respiratory tract - OBOL:automatic + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The ring-shaped cartilaginous structures that support the trachea. + check whether to classify as part of splanchoncranium + + in mammals the rings are incomplete, in avians the rings are complete. + + + + EMAPA:18699 + EMAPA:35875 + FMA:7434 + MA:0001857 + NCIT:C49304 + UMLS:C1710456 + cartilage of trachea + cartilage of windpipe + cartilaginous ring of trachea + cartilaginous trachea cartilage + cartilago trachealis + tracheal cartilage + windpipe cartilage + uberon + cartilage of the trachea + cartilagines tracheales + ring of the trachea + trachea ring + tracheal ring + UBERON:0003604 + + + trachea cartilage + http://upload.wikimedia.org/wikipedia/commons/5/56/Gray952.png + + + + + The ring-shaped cartilaginous structures that support the trachea. + + J:97123 + MGI:smb + MP:0003120 + + + + + UMLS:C1710456 + ncithesaurus:Trachea_Cartilage + + + + + cartilage of trachea + OBOL:automatic + + + + + cartilage of windpipe + OBOL:automatic + + + + + cartilaginous ring of trachea + EMAPA:18699 + + + + + cartilaginous trachea cartilage + OBOL:automatic + + + + + cartilago trachealis + FMA:7434 + + + + + tracheal cartilage + FMA:7434 + + + + + windpipe cartilage + OBOL:automatic + + + + + cartilage of the trachea + + + + + + cartilagines tracheales + + + + + + + ring of the trachea + + + + + + tracheal ring + @@ -300203,85 +116353,85 @@ The modern definition of neurosecretion has evolved to include the release of an A skin gland that is part of a camera-type eye [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37530 - MA:th + MA:th camera-type eye skin gland - OBOL:automatic + OBOL:automatic camera-type eye skin glands - OBOL:automatic + OBOL:automatic camera-type eye skin glands set - OBOL:automatic + OBOL:automatic skin gland of camera-type eye - OBOL:automatic + OBOL:automatic skin gland of vertebrate eye - OBOL:automatic + OBOL:automatic skin glands of camera-type eye - OBOL:automatic + OBOL:automatic skin glands of vertebrate eye - OBOL:automatic + OBOL:automatic skin glands set of camera-type eye - OBOL:automatic + OBOL:automatic skin glands set of vertebrate eye - OBOL:automatic + OBOL:automatic vertebrate eye skin gland - OBOL:automatic + OBOL:automatic vertebrate eye skin glands - OBOL:automatic + OBOL:automatic vertebrate eye skin glands set - OBOL:automatic + OBOL:automatic @@ -300349,25 +116499,25 @@ The modern definition of neurosecretion has evolved to include the release of an adult aorta elastic connective tissue - OBOL:automatic + OBOL:automatic adult aorta elastic tissue - OBOL:automatic + OBOL:automatic adult aorta textus connectivus elasticus - OBOL:automatic + OBOL:automatic aorta elastic connective tissue - OBOL:automatic + OBOL:automatic @@ -300380,121 +116530,121 @@ The modern definition of neurosecretion has evolved to include the release of an aorta elastic laminae MP:0009862 - + aorta textus connectivus elasticus - OBOL:automatic + OBOL:automatic dorsal aorta elastic connective tissue - OBOL:automatic + OBOL:automatic dorsal aorta elastic tissue - OBOL:automatic + OBOL:automatic dorsal aorta textus connectivus elasticus - OBOL:automatic + OBOL:automatic elastic connective tissue of adult aorta - OBOL:automatic + OBOL:automatic elastic connective tissue of aorta - OBOL:automatic + OBOL:automatic elastic connective tissue of dorsal aorta - OBOL:automatic + OBOL:automatic elastic connective tissue of trunk of aortic tree - OBOL:automatic + OBOL:automatic elastic tissue of adult aorta - OBOL:automatic + OBOL:automatic elastic tissue of aorta - OBOL:automatic + OBOL:automatic elastic tissue of dorsal aorta - OBOL:automatic + OBOL:automatic elastic tissue of trunk of aortic tree - OBOL:automatic + OBOL:automatic textus connectivus elasticus of adult aorta - OBOL:automatic + OBOL:automatic textus connectivus elasticus of aorta - OBOL:automatic + OBOL:automatic textus connectivus elasticus of dorsal aorta - OBOL:automatic + OBOL:automatic textus connectivus elasticus of trunk of aortic tree - OBOL:automatic + OBOL:automatic trunk of aortic tree elastic connective tissue - OBOL:automatic + OBOL:automatic trunk of aortic tree elastic tissue - OBOL:automatic + OBOL:automatic trunk of aortic tree textus connectivus elasticus - OBOL:automatic + OBOL:automatic @@ -300551,31 +116701,31 @@ The modern definition of neurosecretion has evolved to include the release of an elastic connective tissue of heart - OBOL:automatic + OBOL:automatic elastic tissue of heart - OBOL:automatic + OBOL:automatic heart elastic connective tissue - OBOL:automatic + OBOL:automatic heart textus connectivus elasticus - OBOL:automatic + OBOL:automatic textus connectivus elasticus of heart - OBOL:automatic + OBOL:automatic @@ -300630,79 +116780,79 @@ The modern definition of neurosecretion has evolved to include the release of an An elastic tissue that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37579 - MA:th + MA:th apparatus respiratorius elastic connective tissue - OBOL:automatic + OBOL:automatic apparatus respiratorius elastic tissue - OBOL:automatic + OBOL:automatic apparatus respiratorius textus connectivus elasticus - OBOL:automatic + OBOL:automatic elastic connective tissue of apparatus respiratorius - OBOL:automatic + OBOL:automatic elastic connective tissue of respiratory system - OBOL:automatic + OBOL:automatic elastic tissue of apparatus respiratorius - OBOL:automatic + OBOL:automatic elastic tissue of respiratory system - OBOL:automatic + OBOL:automatic respiratory system elastic connective tissue - OBOL:automatic + OBOL:automatic respiratory system textus connectivus elasticus - OBOL:automatic + OBOL:automatic textus connectivus elasticus of apparatus respiratorius - OBOL:automatic + OBOL:automatic textus connectivus elasticus of respiratory system - OBOL:automatic + OBOL:automatic @@ -300755,73 +116905,73 @@ The modern definition of neurosecretion has evolved to include the release of an An elastic tissue that is part of a circulatory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic cardiovascular system elastic connective tissue - OBOL:automatic + OBOL:automatic cardiovascular system textus connectivus elasticus - OBOL:automatic + OBOL:automatic circulatory system elastic connective tissue - OBOL:automatic + OBOL:automatic circulatory system elastic tissue - OBOL:automatic + OBOL:automatic circulatory system textus connectivus elasticus - OBOL:automatic + OBOL:automatic elastic connective tissue of cardiovascular system - OBOL:automatic + OBOL:automatic elastic connective tissue of circulatory system - OBOL:automatic + OBOL:automatic elastic tissue of cardiovascular system - OBOL:automatic + OBOL:automatic elastic tissue of circulatory system - OBOL:automatic + OBOL:automatic textus connectivus elasticus of cardiovascular system - OBOL:automatic + OBOL:automatic textus connectivus elasticus of circulatory system - OBOL:automatic + OBOL:automatic @@ -300870,8 +117020,8 @@ The modern definition of neurosecretion has evolved to include the release of an Elastic tissue layer that lines a blood vessel layer. - http://orcid.org/0000-0002-6601-2165 - https://sourceforge.net/p/obo/mammalian-phenotype-requests/2026/ + + @@ -300884,50 +117034,50 @@ The modern definition of neurosecretion has evolved to include the release of an elastic laminae MP:0006083 - + blood vessel elastic connective tissue - OBOL:automatic + OBOL:automatic blood vessel textus connectivus elasticus - OBOL:automatic + OBOL:automatic elastic connective tissue of blood vessel - OBOL:automatic + OBOL:automatic elastic tissue of blood vessel - OBOL:automatic + OBOL:automatic textus connectivus elasticus of blood vessel - OBOL:automatic + OBOL:automatic vascular elastic lamina - http://orcid.org/0000-0002-6601-2165 + vascular elastic laminae - http://orcid.org/0000-0002-6601-2165 - + + @@ -300976,43 +117126,383 @@ The modern definition of neurosecretion has evolved to include the release of an Elastic tissue that is part of a lung [Automatically generated definition]. - OBOL:automatic + OBOL:automatic elastic connective tissue of lung - OBOL:automatic + OBOL:automatic elastic tissue of lung - OBOL:automatic + OBOL:automatic lung elastic connective tissue - OBOL:automatic + OBOL:automatic lung textus connectivus elasticus - OBOL:automatic + OBOL:automatic textus connectivus elasticus of lung - OBOL:automatic + OBOL:automatic pulmonary elastic fiber - http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An elastic tissue that is part of a bronchus [Automatically generated definition]. + + MA:0001838 + NCIT:C49211 + UMLS:C1707053 + bronchi elastic connective tissue + bronchi elastic tissue + bronchi textus connectivus elasticus + bronchial trunk elastic connective tissue + bronchial trunk elastic tissue + bronchial trunk textus connectivus elasticus + bronchus elastic connective tissue + bronchus textus connectivus elasticus + elastic connective tissue of bronchi + elastic connective tissue of bronchial trunk + elastic connective tissue of bronchus + elastic tissue of bronchi + elastic tissue of bronchial trunk + elastic tissue of bronchus + textus connectivus elasticus of bronchi + textus connectivus elasticus of bronchial trunk + textus connectivus elasticus of bronchus + uberon + UBERON:0003616 + bronchus elastic tissue + + + + + An elastic tissue that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C1707053 + ncithesaurus:Bronchus_Elastic_Tissue + + + + + bronchi elastic connective tissue + OBOL:automatic + + + + + bronchi elastic tissue + OBOL:automatic + + + + + bronchi textus connectivus elasticus + OBOL:automatic + + + + + bronchial trunk elastic connective tissue + OBOL:automatic + + + + + bronchial trunk elastic tissue + OBOL:automatic + + + + + bronchial trunk textus connectivus elasticus + OBOL:automatic + + + + + bronchus elastic connective tissue + OBOL:automatic + + + + + bronchus textus connectivus elasticus + OBOL:automatic + + + + + elastic connective tissue of bronchi + OBOL:automatic + + + + + elastic connective tissue of bronchial trunk + OBOL:automatic + + + + + elastic connective tissue of bronchus + OBOL:automatic + + + + + elastic tissue of bronchi + OBOL:automatic + + + + + elastic tissue of bronchial trunk + OBOL:automatic + + + + + elastic tissue of bronchus + OBOL:automatic + + + + + textus connectivus elasticus of bronchi + OBOL:automatic + + + + + textus connectivus elasticus of bronchial trunk + OBOL:automatic + + + + + textus connectivus elasticus of bronchus + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An elastic tissue that is part of a trachea [Automatically generated definition]. + MA:0001861 + cartilaginous trachea elastic connective tissue + cartilaginous trachea elastic tissue + cartilaginous trachea textus connectivus elasticus + elastic connective tissue of cartilaginous trachea + elastic connective tissue of vertebrate trachea + elastic connective tissue of windpipe + elastic tissue of cartilaginous trachea + elastic tissue of vertebrate trachea + elastic tissue of windpipe + textus connectivus elasticus of cartilaginous trachea + textus connectivus elasticus of vertebrate trachea + textus connectivus elasticus of windpipe + vertebrate trachea elastic connective tissue + vertebrate trachea elastic tissue + vertebrate trachea textus connectivus elasticus + windpipe elastic connective tissue + windpipe elastic tissue + windpipe textus connectivus elasticus + uberon + UBERON:0003617 + trachea elastic tissue + + + + + An elastic tissue that is part of a trachea [Automatically generated definition]. + OBOL:automatic + + + + + cartilaginous trachea elastic connective tissue + OBOL:automatic + + + + + cartilaginous trachea elastic tissue + OBOL:automatic + + + + + cartilaginous trachea textus connectivus elasticus + OBOL:automatic + + + + + elastic connective tissue of cartilaginous trachea + OBOL:automatic + + + + + elastic connective tissue of vertebrate trachea + OBOL:automatic + + + + + elastic connective tissue of windpipe + OBOL:automatic + + + + + elastic tissue of cartilaginous trachea + OBOL:automatic + + + + + elastic tissue of vertebrate trachea + OBOL:automatic + + + + + elastic tissue of windpipe + OBOL:automatic + + + + + textus connectivus elasticus of cartilaginous trachea + OBOL:automatic + + + + + textus connectivus elasticus of vertebrate trachea + OBOL:automatic + + + + + textus connectivus elasticus of windpipe + OBOL:automatic + + + + + vertebrate trachea elastic connective tissue + OBOL:automatic + + + + + vertebrate trachea elastic tissue + OBOL:automatic + + + + + vertebrate trachea textus connectivus elasticus + OBOL:automatic + + + + + windpipe elastic connective tissue + OBOL:automatic + + + + + windpipe elastic tissue + OBOL:automatic + + + + + windpipe textus connectivus elasticus + OBOL:automatic @@ -301051,10 +117541,10 @@ The modern definition of neurosecretion has evolved to include the release of an The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers. + EMAPA:35138 FMA:74433 MA:0002903 - SCTID:48467007 adult aorta tunica media dorsal aorta tunica media trunk of aortic tree tunica media @@ -301077,43 +117567,43 @@ The modern definition of neurosecretion has evolved to include the release of an adult aorta tunica media - OBOL:automatic + OBOL:automatic dorsal aorta tunica media - OBOL:automatic + OBOL:automatic trunk of aortic tree tunica media - OBOL:automatic + OBOL:automatic tunica media of adult aorta - OBOL:automatic + OBOL:automatic tunica media of aorta - OBOL:automatic + OBOL:automatic tunica media of dorsal aorta - OBOL:automatic + OBOL:automatic tunica media of trunk of aortic tree - OBOL:automatic + OBOL:automatic @@ -301153,11 +117643,11 @@ The modern definition of neurosecretion has evolved to include the release of an The innermost layer of the aorta, containing the endothelium and an inner elastic membrane. + BTO:0005553 EMAPA:35137 FMA:74419 MA:0002904 - SCTID:362031007 adult aorta tunica intima dorsal aorta tunica intima trunk of aortic tree tunica intima @@ -301180,43 +117670,43 @@ The modern definition of neurosecretion has evolved to include the release of an adult aorta tunica intima - OBOL:automatic + OBOL:automatic dorsal aorta tunica intima - OBOL:automatic + OBOL:automatic trunk of aortic tree tunica intima - OBOL:automatic + OBOL:automatic tunica intima of adult aorta - OBOL:automatic + OBOL:automatic tunica intima of aorta - OBOL:automatic + OBOL:automatic tunica intima of dorsal aorta - OBOL:automatic + OBOL:automatic tunica intima of trunk of aortic tree - OBOL:automatic + OBOL:automatic @@ -301254,13 +117744,13 @@ The modern definition of neurosecretion has evolved to include the release of an An arterial blood vessel that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37565 - MA:th + MA:th @@ -301294,11 +117784,11 @@ The modern definition of neurosecretion has evolved to include the release of an A muscle organ that attaches to a tail vertebra [Automatically generated definition]. the BTO class may possibly refer to an invertebrate structure + AAO:0000081 BTO:0001905 EMAPA:37759 MA:0000699 - SCTID:113230005 caudal muscle muscle organ of post-vent region muscle organ of tail @@ -301313,37 +117803,37 @@ The modern definition of neurosecretion has evolved to include the release of an A muscle organ that attaches to a tail vertebra [Automatically generated definition]. - OBOL:automatic + OBOL:automatic the BTO class may possibly refer to an invertebrate structure - BTO + BTO EMAPA:37759 - MA:th + MA:th muscle organ of post-vent region - OBOL:automatic + OBOL:automatic muscle organ of tail - OBOL:automatic + OBOL:automatic post-vent region muscle organ - OBOL:automatic + OBOL:automatic @@ -301355,7 +117845,7 @@ The modern definition of neurosecretion has evolved to include the release of an tail muscle organ - OBOL:automatic + OBOL:automatic @@ -301379,6 +117869,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -301405,6 +117896,9 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity). in FMA this contains the pelvic cavity, but this is inconsistent with the concept of abdominopelvic cavity + + + EFO:0000213 EMAPA:36505 FMA:12266 @@ -301412,9 +117906,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0003057 MESH:D034841 NCIT:C12664 - SCTID:361294009 + OpenCyc:Mx4rvZR1TJwpEbGdrcN5Y29ycA UMLS:C0230168 - Wikipedia:Abdominal_cavity galen:AbdominalCavity cavity of abdominal compartment cavity of compartment of abdomen @@ -301424,19 +117917,19 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0003684 abdominal cavity - http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg + http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity). - UBERON:cjm + UBERON:cjm in FMA this contains the pelvic cavity, but this is inconsistent with the concept of abdominopelvic cavity - FMA + FMA @@ -301466,10 +117959,15 @@ The modern definition of neurosecretion has evolved to include the release of an cavitas abdominis - GAID:17 - Wikipedia:Abdominal_cavity + + + + + cavitas abdominis + GAID:17 + @@ -301481,7 +117979,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -301496,23 +117994,24 @@ The modern definition of neurosecretion has evolved to include the release of an - + In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted]. Foramen in the occipital region of neurocranium to allow passage of spinal cord.[TAO] + + + AAO:0010826 - BTO:0006035 EMAPA:37868 FMA:75306 GAID:228 MESH:D005539 NCIT:C12495 - SCTID:244679008 + OpenCyc:Mx4rwOm-FpwpEbGdrcN5Y29ycA TAO:0002045 UMLS:C0016519 - Wikipedia:Foramen_magnum ZFA:0005387 uberon UBERON:0003687 @@ -301520,34 +118019,28 @@ The modern definition of neurosecretion has evolved to include the release of an Design pattern notes: check whether this fits the foramen design pattern foramen magnum - http://upload.wikimedia.org/wikipedia/commons/3/39/Gray130.png + http://upload.wikimedia.org/wikipedia/commons/3/39/Gray130.png In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted]. - Wikipedia:Foramen_magnum + Foramen in the occipital region of neurocranium to allow passage of spinal cord.[TAO] - 2012-08-14 + 2012-08-14 TAO:0002045 - TAO - TAO:wd - - - - - BTO:0006035 - https://orcid.org/0000-0003-4423-4370 + TAO + TAO:wd EMAPA:37868 - MA:th + MA:th @@ -301577,6 +118070,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -301596,13 +118090,15 @@ The modern definition of neurosecretion has evolved to include the release of an The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas. + + + FMA:25524 GAID:250 MESH:D001268 NCIT:C32157 - SCTID:361832004 + OpenCyc:Mx4rwUUIHpwpEbGdrcN5Y29ycA UMLS:C0004168 - Wikipedia:Atlanto-axial_joint atlanto axial joint atlantoaxial joint uberon @@ -301614,13 +118110,13 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0003694 atlanto-axial joint - http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray304.png + http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray304.png The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas. - Wikipedia:Atlanto-axial_joint + @@ -301644,31 +118140,31 @@ The modern definition of neurosecretion has evolved to include the release of an articulatio atlantoaxialis - Wikipedia:Atlanto-axial_joint + articulatio atlantoepistrophica - Wikipedia:Atlanto-axial_joint + atlantoaxial - Wikipedia:Atlanto-axial_joint + lateral atlanto-axial joint - Wikipedia:Atlanto-axial_joint + median atlanto-axial joint - Wikipedia:Atlanto-axial_joint + @@ -301695,15 +118191,16 @@ The modern definition of neurosecretion has evolved to include the release of an The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles. + + + EMAPA:37064 FMA:10429 FMA:259054 GAID:26 MESH:D034861 NCIT:C77608 - SCTID:181613000 UMLS:C0836916 - Wikipedia:Abdominal_wall paries abdominalis wall of abdomen wall of abdomen proper @@ -301714,7 +118211,7 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0003697 abdominal wall - http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg + http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg @@ -301726,7 +118223,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37064 - MA:th + MA:th @@ -301738,7 +118235,7 @@ The modern definition of neurosecretion has evolved to include the release of an paries abdominalis - Wikipedia:Abdominal_wall + @@ -301762,13 +118259,13 @@ The modern definition of neurosecretion has evolved to include the release of an layers of the abdominal wall - Wikipedia:Abdominal_wall + paries abdominalis - Wikipedia:Abdominal_wall + @@ -301781,12 +118278,13 @@ The modern definition of neurosecretion has evolved to include the release of an Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct. includes all the cystic duct, all the common bile duct and the extrahapetic part of the hepatic duct + + FMA:14678 GAID:281 MA:0002659 MESH:D017734 NCIT:C32573 - SCTID:276158002 UMLS:C0206187 uberon bile duct extrahepatic part @@ -301853,12 +118351,13 @@ The modern definition of neurosecretion has evolved to include the release of an Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct. includes the hepatic duct of the caudate lobe, and the intra- and inter- lobar bile ducts Duct that collects bile from the bile ductules and connects to the extrahepatic bile duct.[TAO] + + FMA:15766 GAID:287 MA:0001630 MESH:D001653 NCIT:C12677 - SCTID:362193005 TAO:0005169 UMLS:C0005401 ZFA:0005169 @@ -301874,7 +118373,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -301885,7 +118384,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -301897,10 +118396,10 @@ The modern definition of neurosecretion has evolved to include the release of an Duct that collects bile from the bile ductules and connects to the extrahepatic bile duct.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005169 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -301941,15 +118440,17 @@ The modern definition of neurosecretion has evolved to include the release of an The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava. + + + EHDAA2:0000182 EHDAA:9868 FMA:4723 GAID:529 MESH:D016121 NCIT:C32816 - SCTID:181371003 + OpenCyc:Mx4rvz3aUJwpEbGdrcN5Y29ycA UMLS:C0006095 - Wikipedia:Brachiocephalic_vein galen:BrachiocephalicVein brachiocephalic venous tree innominate vein @@ -301963,13 +118464,13 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0003711 brachiocephalic vein - http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray1174.png + http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray1174.png The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava. - Wikipedia:Brachiocephalic_vein + @@ -301993,39 +118494,50 @@ The modern definition of neurosecretion has evolved to include the release of an innomiate vein - Wikipedia:Brachiocephalic_vein + innominate trunk - Wikipedia:Brachiocephalic_vein + + + + + + innominate vein + innominate vein GAID:529 - Wikipedia:Brachiocephalic_vein innominate veins - Wikipedia:Brachiocephalic_vein + + + + + + vena brachiocephalica + vena brachiocephalica - Wikipedia:Brachiocephalic_vein + venae anonyma - Wikipedia:Brachiocephalic_vein + @@ -302049,15 +118561,17 @@ The modern definition of neurosecretion has evolved to include the release of an A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein. + + + EMAPA:37226 FMA:14331 GAID:541 MA:0002164 MESH:D013162 NCIT:C33608 - SCTID:278029005 + OpenCyc:Mx4rwCt0eZwpEbGdrcN5Y29ycA UMLS:C0038001 - Wikipedia:Splenic_vein galen:SplenicVein vena splenica uberon @@ -302066,10 +118580,8 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0003713 splenic vein - http://upload.wikimedia.org/wikipedia/commons/5/5b/Gray1189.png - http://upload.wikimedia.org/wikipedia/commons/e/e4/Bilebladder.png - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb + http://upload.wikimedia.org/wikipedia/commons/5/5b/Gray1189.png + http://upload.wikimedia.org/wikipedia/commons/e/e4/Bilebladder.png @@ -302081,7 +118593,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37226 - MA:th + MA:th @@ -302094,21 +118606,21 @@ The modern definition of neurosecretion has evolved to include the release of an vena splenica FMA:14331 - FMA:TA + FMA:TA lienal vein + MA:0002164 - Wikipedia:Splenic_vein vena lienalis - Wikipedia:Splenic_vein + @@ -302133,6 +118645,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -302155,6 +118668,8 @@ The modern definition of neurosecretion has evolved to include the release of an Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature. One of the four types of tissue in traditional classifications. Cells forming the brain, spinal cord and peripheral nervous system.[AAO] FMA definition includes vasculature + + AAO:0000325 AEO:0000123 EHDAA2:0003123 @@ -302162,7 +118677,7 @@ The modern definition of neurosecretion has evolved to include the release of an GAID:609 MESH:D009417 NCIT:C13052 - SCTID:91728009 + OpenCyc:Mx4rVmfYCsQ_QdeM_bFAeS8NRQ UMLS:C0027757 nerve tissue nervous tissue @@ -302181,16 +118696,16 @@ The modern definition of neurosecretion has evolved to include the release of an One of the four types of tissue in traditional classifications. Cells forming the brain, spinal cord and peripheral nervous system.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000325 - AAO - AAO:LAP + AAO + AAO:LAP FMA definition includes vasculature - FMA + FMA @@ -302254,13 +118769,13 @@ The modern definition of neurosecretion has evolved to include the release of an The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia. All carry sympathetic fibers except for the pelvic splanchnic nerves, which carry parasympathetic fibers + + BAMS:spn EMAPA:37959 FMA:5883 GAID:800 MESH:D013153 - SCTID:264198001 - Wikipedia:Splanchnic_nerves uberon splanchnic nerves visceral nerve @@ -302278,7 +118793,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37959 - MA:th + MA:th @@ -302290,7 +118805,7 @@ The modern definition of neurosecretion has evolved to include the release of an visceral nerve - Wikipedia:Splanchnic_nerves + @@ -302317,11 +118832,12 @@ The modern definition of neurosecretion has evolved to include the release of an The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls. + + FMA:5860 GAID:857 MESH:D013900 - SCTID:360498003 - Wikipedia:Thoracic_nerves + OpenCyc:Mx4rwSJp_ZwpEbGdrcN5Y29ycA neuronames:1725 nervus thoracis thoracic spinal nerve @@ -302342,7 +118858,7 @@ The modern definition of neurosecretion has evolved to include the release of an nervus thoracis FMA:5860 - FMA:TA + FMA:TA @@ -302355,7 +118871,7 @@ The modern definition of neurosecretion has evolved to include the release of an nervi thoracici - Wikipedia:Thoracic_nerves + @@ -302372,14 +118888,15 @@ The modern definition of neurosecretion has evolved to include the release of an The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted]. + + + EMAPA:18227 FMA:6028 GAID:858 MESH:D007367 NCIT:C32825 - SCTID:279568001 UMLS:C1285089 - Wikipedia:Intercostal_nerves anterior ramus of thoracic nerve anterior ramus of thoracic spinal nerve ramus anterior, nervus thoracicus @@ -302389,13 +118906,13 @@ The modern definition of neurosecretion has evolved to include the release of an nervi intercostales UBERON:0003727 intercostal nerve - http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray819.png + http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray819.png The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted]. - Wikipedia:Intercostal_nerves + @@ -302437,7 +118954,7 @@ The modern definition of neurosecretion has evolved to include the release of an nervi intercostales - Wikipedia:Intercostal_nerves + @@ -302458,6 +118975,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -302491,6 +119009,8 @@ The modern definition of neurosecretion has evolved to include the release of an A mucous membrane that lines the mouth. this is defined as any mucous membrane of the mouth - including palate, lips, uvula, etc. ncit split mouth/oral mucosa into lip and buccal. In future we may split into masticatory/keratinized (gingiva + hard palate) vs lining/non-keratinized (lips, cheeks, floor of mouth, soft palate). FMA distinguishes between mucosa of mouth and region of mouth (the latter including the buccal mucosa) the mucous membrane epithelium of the mouth. It can be divided into three categories: masticatory, lining, and specialized[Wikipedia:Oral_mucosa]. + + BTO:0002860 CALOHA:TS-0716 EMAPA:26937 @@ -302500,7 +119020,6 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D009061 NCIT:C77637 UMLS:C0026639 - Wikipedia:Oral_mucosa mouth mucosa mouth mucous membrane mouth organ mucosa @@ -302522,13 +119041,13 @@ The modern definition of neurosecretion has evolved to include the release of an A mucous membrane that lines the mouth. - http://orcid.org/0000-0002-6601-2165 + the mucous membrane epithelium of the mouth. It can be divided into three categories: masticatory, lining, and specialized[Wikipedia:Oral_mucosa]. - Wikipedia:Oral_mucosa + @@ -302546,19 +119065,19 @@ The modern definition of neurosecretion has evolved to include the release of an mouth mucous membrane - OBOL:accepted + OBOL:accepted mouth organ mucosa - OBOL:accepted + OBOL:accepted mucosa of mouth - OBOL:accepted + OBOL:accepted @@ -302577,7 +119096,7 @@ The modern definition of neurosecretion has evolved to include the release of an tunica mucosa oris FMA:59660 - FMA:TA + FMA:TA @@ -302602,7 +119121,7 @@ The modern definition of neurosecretion has evolved to include the release of an tunica mucosa oris - Wikipedia:Oral_mucosa + @@ -302630,10 +119149,10 @@ The modern definition of neurosecretion has evolved to include the release of an A nerve that is part of a thorax [Automatically generated definition]. + EMAPA:37265 MA:0000562 MESH:D013900 - SCTID:359876006 nerve of thorax thoracic segment nerve thorax nerve @@ -302646,19 +119165,19 @@ The modern definition of neurosecretion has evolved to include the release of an A nerve that is part of a thorax [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37265 - MA:th + MA:th nerve of thorax - OBOL:automatic + OBOL:automatic @@ -302670,7 +119189,7 @@ The modern definition of neurosecretion has evolved to include the release of an thorax nerve - OBOL:automatic + OBOL:automatic @@ -302714,13 +119233,13 @@ The modern definition of neurosecretion has evolved to include the release of an A nerve that is part of an abdominal segment of trunk [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37061 - MA:th + MA:th @@ -302754,9 +119273,9 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a thorax [Automatically generated definition]. + EMAPA:37247 MA:0000559 - SCTID:426649006 bone of thorax bone organ of thorax thorax bone @@ -302770,37 +119289,37 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a thorax [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37247 - MA:th + MA:th bone of thorax - OBOL:automatic + OBOL:automatic bone organ of thorax - OBOL:automatic + OBOL:automatic thorax bone - OBOL:automatic + OBOL:automatic thorax bone organ - OBOL:automatic + OBOL:automatic @@ -302848,37 +119367,37 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of an abdominal segment of trunk [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37058 - MA:th + MA:th abdominal segment of trunk bone - OBOL:automatic + OBOL:automatic abdominal segment of trunk bone organ - OBOL:automatic + OBOL:automatic bone of abdominal segment of trunk - OBOL:automatic + OBOL:automatic bone organ of abdominal segment of trunk - OBOL:automatic + OBOL:automatic @@ -302929,25 +119448,25 @@ The modern definition of neurosecretion has evolved to include the release of an - prolog + prolog Any muscle organ that is part of a thorax [Automatically generated definition]. - OBOL:automatic + OBOL:automatic muscle organ of thorax - OBOL:automatic + OBOL:automatic thorax muscle organ - OBOL:automatic + OBOL:automatic @@ -302994,31 +119513,31 @@ The modern definition of neurosecretion has evolved to include the release of an Any muscle organ that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic apparatus respiratorius muscle organ - OBOL:automatic + OBOL:automatic muscle organ of apparatus respiratorius - OBOL:automatic + OBOL:automatic muscle organ of respiratory system - OBOL:automatic + OBOL:automatic respiratory system muscle organ - OBOL:automatic + OBOL:automatic @@ -303054,9 +119573,9 @@ The modern definition of neurosecretion has evolved to include the release of an Any muscle organ that is part of a esophagus [Automatically generated definition]. merge muscle and muscle layer? + EMAPA:26983 MA:0002682 - SCTID:360961009 esophageal muscle esophagus muscle organ gullet muscle organ @@ -303077,49 +119596,49 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA Any muscle organ that is part of a esophagus [Automatically generated definition]. - OBOL:automatic + OBOL:automatic esophagus muscle organ - OBOL:automatic + OBOL:automatic gullet muscle organ - OBOL:automatic + OBOL:automatic muscle organ of esophagus - OBOL:automatic + OBOL:automatic muscle organ of gullet - OBOL:automatic + OBOL:automatic muscle organ of oesophagus - OBOL:automatic + OBOL:automatic oesophagus muscle organ - OBOL:automatic + OBOL:automatic @@ -303159,25 +119678,25 @@ The modern definition of neurosecretion has evolved to include the release of an A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37060 - MA:th + MA:th abdominal segment of trunk muscle organ - OBOL:automatic + OBOL:automatic muscle organ of abdominal segment of trunk - OBOL:automatic + OBOL:automatic @@ -303217,25 +119736,25 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a thorax [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37238 - MA:th + MA:th blood vessel of thorax - OBOL:automatic + OBOL:automatic thorax blood vessel - OBOL:automatic + OBOL:automatic @@ -303280,25 +119799,25 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37057 - MA:th + MA:th abdominal segment of trunk blood vessel - OBOL:automatic + OBOL:automatic blood vessel of abdominal segment of trunk - OBOL:automatic + OBOL:automatic @@ -303338,25 +119857,25 @@ The modern definition of neurosecretion has evolved to include the release of an A skin of body that is part of an abdominal segment of trunk [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37063 - MA:th + MA:th abdominal segment of trunk skin - OBOL:automatic + OBOL:automatic skin of abdominal segment of trunk - OBOL:automatic + OBOL:automatic @@ -303400,49 +119919,49 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of connective tissue that is part of a thorax [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37253 - MA:th + MA:th connective tissue of thorax - OBOL:automatic + OBOL:automatic portion of connective tissue of thorax - OBOL:automatic + OBOL:automatic textus connectivus of thorax - OBOL:automatic + OBOL:automatic thorax connective tissue - OBOL:automatic + OBOL:automatic thorax portion of connective tissue - OBOL:automatic + OBOL:automatic thorax textus connectivus - OBOL:automatic + OBOL:automatic @@ -303491,49 +120010,49 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37059 - MA:th + MA:th abdominal segment of trunk connective tissue - OBOL:automatic + OBOL:automatic abdominal segment of trunk portion of connective tissue - OBOL:automatic + OBOL:automatic abdominal segment of trunk textus connectivus - OBOL:automatic + OBOL:automatic connective tissue of abdominal segment of trunk - OBOL:automatic + OBOL:automatic portion of connective tissue of abdominal segment of trunk - OBOL:automatic + OBOL:automatic textus connectivus of abdominal segment of trunk - OBOL:automatic + OBOL:automatic @@ -303553,6 +120072,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -303590,29 +120110,29 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical space that surrounded_by a neural tube. - OBOL:automatic + OBOL:automatic (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001119 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 - http://bgee.unil.ch/ cavity of neural tube - https://orcid.org/0000-0002-6601-2165 + lumen of neural tube - https://orcid.org/0000-0002-6601-2165 + @@ -303663,11 +120183,12 @@ The modern definition of neurosecretion has evolved to include the release of an In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted]. + + EHDAA2:0000719 EHDAA:8703 - SCTID:278192008 + OpenCyc:Mx4rvlWYh5wpEbGdrcN5Y29ycA VHOG:0001340 - Wikipedia:Gonadal_vein gonad vein gonada vein vein of gonad @@ -303675,37 +120196,37 @@ The modern definition of neurosecretion has evolved to include the release of an uberon UBERON:0003848 gonadal vein - http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png + http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted]. - Wikipedia:Gonadal_vein + gonad vein - OBOL:automatic + OBOL:automatic gonada vein - OBOL:automatic + OBOL:automatic vein of gonad - OBOL:automatic + OBOL:automatic vein of gonada - OBOL:automatic + OBOL:automatic @@ -303752,23 +120273,23 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA A neural crest that has_potential_to_developmentally_contribute_to a midbrain. - OBOL:automatic + OBOL:automatic We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000796 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 - http://bgee.unil.ch/ @@ -303828,32 +120349,32 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA A neural crest that has_potential_to_developmentally_contribute_to a hindbrain. - OBOL:automatic + OBOL:automatic Cranial neural crest that is part of the hindbrain.[TAO] - 2012-08-14 + 2012-08-14 TAO:0007063 - TAO - ZFIN:curator + TAO + ZFIN:curator We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001210 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 - http://bgee.unil.ch/ @@ -303913,17 +120434,17 @@ The modern definition of neurosecretion has evolved to include the release of an A neural crest that has_potential_to_developmentally_contribute_to a spinal cord. - OBOL:automatic + OBOL:automatic We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...)[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001006 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 - http://bgee.unil.ch/ @@ -303982,38 +120503,38 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA A neural plate that develops_from a future spinal cord. - OBOL:automatic + OBOL:automatic Neural plate that is part of the spinal cord. [Bgee_curator][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000439 - VHOG - http://bgee.unil.ch/ + VHOG + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...)[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000439 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 - http://bgee.unil.ch/ neural plate of spinal cord - OBOL:automatic + OBOL:automatic @@ -304032,6 +120553,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -304057,25 +120579,25 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a developing gonad [Automatically generated definition]. - OBOL:automatic + OBOL:automatic gonada mesenchyme - OBOL:automatic + OBOL:automatic mesenchyme of gonad - OBOL:automatic + OBOL:automatic mesenchyme of gonada - OBOL:automatic + OBOL:automatic @@ -304110,7 +120632,7 @@ The modern definition of neurosecretion has evolved to include the release of an A presumptive structure that has the potential to develop into a ganglion. - OBOL:automatic + OBOL:automatic @@ -304130,6 +120652,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -304167,7 +120690,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical cavity that has the potential to develop into a coelemic cavity lumen. - OBOL:automatic + OBOL:automatic @@ -304175,6 +120698,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -304191,12 +120715,13 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom. consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults (...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG] + + EHDAA:251 EMAPA:16088 NCIT:C34195 UMLS:C1512940 VHOG:0000316 - Wikipedia:Intraembryonic_coelom somatic coelom uberon UBERON:0003887 @@ -304212,24 +120737,24 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom. - MGI:anna + MGI:anna MP:0012187 (...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000316 - VHOG + VHOG + ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.166 - http://bgee.unil.ch/ @@ -304241,7 +120766,7 @@ The modern definition of neurosecretion has evolved to include the release of an somatic coelom - Wikipedia:Intraembryonic_coelom + @@ -304264,6 +120789,7 @@ The modern definition of neurosecretion has evolved to include the release of an Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma. stromal + FMA:81494 NCIT:C67387 UMLS:C0927195 @@ -304277,7 +120803,7 @@ The modern definition of neurosecretion has evolved to include the release of an Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma. - http://orcid.org/0000-0002-6601-2165 + @@ -304327,6 +120853,8 @@ The modern definition of neurosecretion has evolved to include the release of an A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum. consider adding further subdivisions of the endoderm, e.g. ventral foregut. Note we place two EFO classes here, it's not clear how they differ + + AAO:0011058 BTO:0003391 EFO:0002577 @@ -304356,13 +120884,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 - XAO + XAO @@ -304373,7 +120901,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -304409,7 +120937,7 @@ The modern definition of neurosecretion has evolved to include the release of an embryological hepatic plate - https://orcid.org/0000-0002-6601-2165 + @@ -304531,7 +121059,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of skeletal muscle tissue in the trunk. - SCTID:244848007 + skeletal muscle of torso skeletal muscle tissue of torso skeletal muscle tissue of trunk @@ -304552,55 +121080,55 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + A portion of skeletal muscle tissue in the trunk. - http://orcid.org/0000-0002-6601-2165 + skeletal muscle of torso - OBOL:automatic + OBOL:automatic skeletal muscle tissue of torso - OBOL:automatic + OBOL:automatic skeletal muscle tissue of trunk - OBOL:automatic + OBOL:automatic torso skeletal muscle - OBOL:automatic + OBOL:automatic torso skeletal muscle tissue - OBOL:automatic + OBOL:automatic trunk skeletal muscle - OBOL:automatic + OBOL:automatic trunk skeletal muscle tissue - OBOL:automatic + OBOL:automatic @@ -304651,8 +121179,8 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the retina that contains neurons and photoreceptor cells[GO]. - (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG] + AAO:0011095 BTO:0000929 CALOHA:TS-0685 @@ -304676,7 +121204,6 @@ The modern definition of neurosecretion has evolved to include the release of an uberon neural retinal epithelium UBERON:0003902 - retinal neural layer @@ -304690,7 +121217,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Bgee:AN + Bgee:AN @@ -304702,11 +121229,11 @@ The modern definition of neurosecretion has evolved to include the release of an (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000535 - VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 - http://bgee.unil.ch/ + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 @@ -304744,7 +121271,7 @@ The modern definition of neurosecretion has evolved to include the release of an stratum nervosum retinae FMA:58628 - FMA:TA + FMA:TA @@ -304765,10 +121292,10 @@ The modern definition of neurosecretion has evolved to include the release of an Fenestrated blood vessel endothelium with pores that are large enough for blood cells to pass. The basal lamina and gap junctions may be discontinuous.[TAO] sinusoidal some sources give discontinuous capillary as synonym but this may be a subtype - see FMA:63198 discontinuous sinusoid (undefined). + + FMA:63131 - SCTID:340163004 TAO:0005261 - Wikipedia:Sinusoid_(blood_vessel) ZFA:0005261 sinusoidal blood vessel sinusoidal blood vessel endothelium @@ -304790,29 +121317,29 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia - ZFA + Wikipedia + ZFA Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP]. - Wikipedia:Sinusoid_(blood_vessel) + Fenestrated blood vessel endothelium with pores that are large enough for blood cells to pass. The basal lamina and gap junctions may be discontinuous.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005261 - TAO - ZFIN:curator + TAO + ZFIN:curator some sources give discontinuous capillary as synonym but this may be a subtype - see FMA:63198 discontinuous sinusoid (undefined). - FMA + FMA @@ -304824,7 +121351,7 @@ The modern definition of neurosecretion has evolved to include the release of an sinusoidal capillary - http://www.medilexicon.com/medicaldictionary.php?t=13986 + @@ -304865,8 +121392,8 @@ The modern definition of neurosecretion has evolved to include the release of an Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + GO:0060562 - PMID:12526790 @@ -304902,7 +121429,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any endothelium that has the quality of being cylindrical [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -304929,7 +121456,6 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that carries blood from the capillaries toward the heart. - EMAPA:35932 FMA:86188 MA:0000066 @@ -304937,7 +121463,6 @@ The modern definition of neurosecretion has evolved to include the release of an venous tree organ segment uberon UBERON:0003920 - Compare to: vein venous blood vessel @@ -304945,7 +121470,7 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that carries blood from the capillaries toward the heart. - http://www.thefreedictionary.com/venous+blood+vessel + @@ -305023,7 +121548,7 @@ The modern definition of neurosecretion has evolved to include the release of an pancreas primordium - http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png + http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png @@ -305034,19 +121559,19 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia Embryonic structure that develops into pancreatic bud. - Wikipedia:Pancreas#Embryological_development + in EHDAA2 this has dorsal and ventral primordia as parts. the buds are part of the primordium, with the ducts developing from the buds; only parenchyma and ducts have contribution from buds - EHDAA2 + EHDAA2 @@ -305106,13 +121631,14 @@ The modern definition of neurosecretion has evolved to include the release of an The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID]. + + + EFO:0003470 EMAPA:35645 NCIT:C34242 - SCTID:360398004 TAO:0001390 UMLS:C1283285 - Wikipedia:Pancreatic_bud ZFA:0001390 pancreatic bud pancreatic buds @@ -305122,14 +121648,14 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0003922 pancreatic epithelial bud - http://upload.wikimedia.org/wikipedia/commons/4/49/Suckale08FBS_fig1_pancreas_development.jpeg - http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png + http://upload.wikimedia.org/wikipedia/commons/4/49/Suckale08FBS_fig1_pancreas_development.jpeg + http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png - EHDAA2 + EHDAA2 @@ -305140,7 +121666,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -305151,7 +121677,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia:Pancreas#Embryological_development + @@ -305163,7 +121689,7 @@ The modern definition of neurosecretion has evolved to include the release of an zebrafish - Wikipedia:Pancreatic_bud + @@ -305180,8 +121706,8 @@ The modern definition of neurosecretion has evolved to include the release of an The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID]. - PMID:16417468 - Wikipedia:Pancreatic_bud + + @@ -305200,7 +121726,7 @@ The modern definition of neurosecretion has evolved to include the release of an pancreatic buds TAO:0001390 - + @@ -305230,14 +121756,14 @@ The modern definition of neurosecretion has evolved to include the release of an Pancreatic bud that gives rise to the accessory pancreatic duct. The pancreatic bud that gives rise to the accessory pancreatic duct.[AAO] In chick, Xenopus laevis, and the teleost fish Medaka, the pancreas develops from three buds that emerge from the gut tube, two from its ventral aspect, and one from its dorsal aspect. In mouse, although there are initially three buds that arise from the gut tube at the point of contact between the endoderm and the vasculature, the pancreas develops from only two of these buds, one dorsal and one ventral. (...) In this study, we use a transgenic zebrafish line (...). We provide evidence for the existence of two distinct pancreatic anlagen - a ventral anterior bud and a dorsal posterior bud - that join to form the definitive pancreas (reference 1); The pancreas develops from the fusion of distinct endoderm-derived dorsal and ventral diverticula. In humans, by day 35 of development, the ventral pancreatic bud begins to migrate backwards and comes into contact and eventually fuses with the dorsal pancreatic bud during the sixth week of development (reference 2).[well established][VHOG] + + AAO:0011031 EFO:0003465 EHDAA2:0001385 EMAPA:17067 - SCTID:361435005 TAO:0001370 VHOG:0001428 - Wikipedia:Pancreatic_bud XAO:0000467 ZFA:0001370 pancreas dorsal primordium duct bud @@ -305252,7 +121778,7 @@ The modern definition of neurosecretion has evolved to include the release of an dorsal pancreatic bud - http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png + http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png @@ -305263,7 +121789,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -305274,32 +121800,32 @@ The modern definition of neurosecretion has evolved to include the release of an - XAO + XAO Pancreatic bud that gives rise to the accessory pancreatic duct. - Wikipedia:Pancreatic_bud + The pancreatic bud that gives rise to the accessory pancreatic duct.[AAO] - 2012-06-20 + 2012-06-20 AAO:0011031 - AAO + AAO XAO:curator In chick, Xenopus laevis, and the teleost fish Medaka, the pancreas develops from three buds that emerge from the gut tube, two from its ventral aspect, and one from its dorsal aspect. In mouse, although there are initially three buds that arise from the gut tube at the point of contact between the endoderm and the vasculature, the pancreas develops from only two of these buds, one dorsal and one ventral. (...) In this study, we use a transgenic zebrafish line (...). We provide evidence for the existence of two distinct pancreatic anlagen - a ventral anterior bud and a dorsal posterior bud - that join to form the definitive pancreas (reference 1); The pancreas develops from the fusion of distinct endoderm-derived dorsal and ventral diverticula. In humans, by day 35 of development, the ventral pancreatic bud begins to migrate backwards and comes into contact and eventually fuses with the dorsal pancreatic bud during the sixth week of development (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001428 - VHOG + VHOG + DOI:10.1016/S0012-1606(03)00308-7 Field HA, Dong PD, Beis D, Stainier DY, Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Developmental Biology (2003), DOI:10.2337/diabetes.49.2.225 Polak M, Bouchareb-Banaei L, Scharfmann R, Czernichow P, Early pattern of differentiation in the human pancreas. Diabetes (2000) - http://bgee.unil.ch/ @@ -305336,14 +121862,14 @@ The modern definition of neurosecretion has evolved to include the release of an In chick, Xenopus laevis, and the teleost fish Medaka, the pancreas develops from three buds that emerge from the gut tube, two from its ventral aspect, and one from its dorsal aspect. In mouse, although there are initially three buds that arise from the gut tube at the point of contact between the endoderm and the vasculature, the pancreas develops from only two of these buds, one dorsal and one ventral. (...) In this study, we use a transgenic zebrafish line (...). We provide evidence for the existence of two distinct pancreatic anlagen - a ventral anterior bud and a dorsal posterior bud - that join to form the definitive pancreas (reference 1); The pancreas develops from the fusion of distinct endoderm-derived dorsal and ventral diverticula. In humans, by day 35 of development, the ventral pancreatic bud begins to migrate backwards and comes into contact and eventually fuses with the dorsal pancreatic bud during the sixth week of development (reference 2).[well established][VHOG] The ventral pancreatic bud becomes the head and uncinate process, and comes from the hepatic diverticulum[WP] the ventral pancreas and liver are derived from a common precursor cell population[PMID:16417468]. TODO - add this relationship. + + AAO:0011111 EFO:0003464 EHDAA2:0001389 EMAPA:17256 - SCTID:361437002 TAO:0001369 VHOG:0001429 - Wikipedia:Pancreatic_bud XAO:0001103 ZFA:0001369 pancreas primordium ventral bud @@ -305357,7 +121883,7 @@ The modern definition of neurosecretion has evolved to include the release of an ventral pancreatic bud - http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png + http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png @@ -305368,7 +121894,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -305379,24 +121905,24 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:16417468 - WP + + WP Pancreatic bud that gives rise to the major pancreatic duct. - Wikipedia:Pancreatic_bud + In chick, Xenopus laevis, and the teleost fish Medaka, the pancreas develops from three buds that emerge from the gut tube, two from its ventral aspect, and one from its dorsal aspect. In mouse, although there are initially three buds that arise from the gut tube at the point of contact between the endoderm and the vasculature, the pancreas develops from only two of these buds, one dorsal and one ventral. (...) In this study, we use a transgenic zebrafish line (...). We provide evidence for the existence of two distinct pancreatic anlagen - a ventral anterior bud and a dorsal posterior bud - that join to form the definitive pancreas (reference 1); The pancreas develops from the fusion of distinct endoderm-derived dorsal and ventral diverticula. In humans, by day 35 of development, the ventral pancreatic bud begins to migrate backwards and comes into contact and eventually fuses with the dorsal pancreatic bud during the sixth week of development (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001429 - VHOG + VHOG + DOI:10.1016/S0012-1606(03)00308-7 Field HA, Dong PD, Beis D, Stainier DY, Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Developmental Biology (2003), DOI:10.2337/diabetes.49.2.225 Polak M, Bouchareb-Banaei L, Scharfmann R, Czernichow P, Early pattern of differentiation in the human pancreas. Diabetes (2000) - http://bgee.unil.ch/ @@ -305442,25 +121968,25 @@ The modern definition of neurosecretion has evolved to include the release of an A duct that is part of a digestive system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic duct of digestive system - OBOL:automatic + OBOL:automatic duct of gastrointestinal system - OBOL:automatic + OBOL:automatic gastrointestinal system duct - OBOL:automatic + OBOL:automatic @@ -305480,6 +122006,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -305489,10 +122016,10 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that lines the lumen of the digestive tract. Epithelium lining the lumen of the gut.[TAO] + BTO:0000956 EHDAA2:0004567 EMAPA:32928 - FBbt:00047166 MA:0003201 NCIT:C12963 TAO:0005123 @@ -305516,16 +122043,16 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that lines the lumen of the digestive tract. - http://orcid.org/0000-0002-6601-2165 + Epithelium lining the lumen of the gut.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005123 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -305537,45 +122064,45 @@ The modern definition of neurosecretion has evolved to include the release of an digestive tract epithelial tissue - OBOL:automatic + OBOL:automatic epithelial tissue of digestive tract - OBOL:automatic + OBOL:automatic epithelial tissue of gut - OBOL:automatic + OBOL:automatic epithelium of digestive tract - OBOL:automatic + OBOL:automatic epithelium of gut - OBOL:automatic + OBOL:automatic gastrodermis + NCBITaxon:6073 - https://orcid.org/0000-0003-3308-6245 gut epithelial tissue - OBOL:automatic + OBOL:automatic @@ -305589,7 +122116,7 @@ The modern definition of neurosecretion has evolved to include the release of an alimentary tract epithelium - OBOL:automatic + OBOL:automatic @@ -305632,19 +122159,19 @@ The modern definition of neurosecretion has evolved to include the release of an A cartilage element of chondrocranium. Example: neurocranial trabecula. - https://orcid.org/0000-0002-6601-2165 + cartilage of chondrocranium - OBOL:accepted + OBOL:accepted cartilaginous element of chondrocranium - OBOL:accepted + OBOL:accepted @@ -305697,36 +122224,36 @@ The modern definition of neurosecretion has evolved to include the release of an A cartilage element that is part of the cranial skeleton. + ZFA:0001458 - https://orcid.org/0000-0002-6601-2165 Cartilage which is part of the cranium.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001458 - TAO - ZFIN:curator + TAO + ZFIN:curator cartilage of cranium - OBOL:automatic + OBOL:automatic cranium cartilage - OBOL:automatic + OBOL:automatic cranial cartilages ZFA:0001458 - + @@ -305754,7 +122281,6 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction. - BTO:0006162 MA:0001751 genitalia gland gland of genitalia @@ -305774,17 +122300,11 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction. MP:0000653 - - - - BTO:0006162 - https://orcid.org/0000-0003-4423-4370 - genitalia gland - OBOL:automatic + OBOL:automatic @@ -305796,7 +122316,7 @@ The modern definition of neurosecretion has evolved to include the release of an gland of reproductive system - OBOL:automatic + OBOL:automatic @@ -305808,7 +122328,7 @@ The modern definition of neurosecretion has evolved to include the release of an reproductive system gland - OBOL:automatic + OBOL:automatic @@ -305839,9 +122359,9 @@ The modern definition of neurosecretion has evolved to include the release of an The neural tissue involved in the transmission of sensory signals MP defines this in a may more appropriate to somatosensory cortex UBERON:0014511 + EMAPA:37954 NLXANAT:090818 - Wikipedia:Somatosensory_system neuronames:2887 somatic sensory system system for detection of somatic senses @@ -305872,7 +122392,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37954 - MA:th + MA:th @@ -305927,7 +122447,7 @@ The modern definition of neurosecretion has evolved to include the release of an - lexical + lexical @@ -305945,7 +122465,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37414 - MA:th + MA:th @@ -306003,7 +122523,7 @@ The modern definition of neurosecretion has evolved to include the release of an - lexical + lexical @@ -306021,7 +122541,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37415 - MA:th + MA:th @@ -306079,7 +122599,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37841 - MA:th + MA:th @@ -306119,9 +122639,9 @@ The modern definition of neurosecretion has evolved to include the release of an The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina. + BTO:0003099 FMA:45654 - SCTID:303518005 female internal genitalia internal female genital organ internal genitalia of female reproductive system @@ -306155,7 +122675,7 @@ The modern definition of neurosecretion has evolved to include the release of an internal genitalia of female reproductive system - OBOL:automatic + OBOL:automatic @@ -306215,6 +122735,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -306230,9 +122751,10 @@ The modern definition of neurosecretion has evolved to include the release of an A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells. Not to be confused with 'dermatome segment of skin'. + + AAO:0011028 AEO:0001017 - BTO:0006248 EHDAA2_RETIRED:0003428 EHDAA:1719 EHDAA:1725 @@ -306242,7 +122764,6 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:295656 NCIT:C61572 UMLS:C0180383 - Wikipedia:Dermatome_(embryology) XAO:0000220 cutis plate dermatomal mesenchyme @@ -306252,13 +122773,13 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0004016 dermatome - http://upload.wikimedia.org/wikipedia/commons/f/f3/Gray64.png + http://upload.wikimedia.org/wikipedia/commons/f/f3/Gray64.png - AEO + AEO @@ -306280,7 +122801,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2-abduced + EHDAA2-abduced @@ -306289,12 +122810,6 @@ The modern definition of neurosecretion has evolved to include the release of an AEO:0001017 AEO:JB - - - - BTO:0006248 - https://orcid.org/0000-0003-4423-4370 - @@ -306305,19 +122820,19 @@ The modern definition of neurosecretion has evolved to include the release of an cutis plate - Wikipedia:Cutis_plate + dermatomal mesenchyme - Wikipedia:Cutis_plate + mesenchyma dermatomiale - Wikipedia:Dermatomal_mesenchyme + @@ -306347,7 +122862,6 @@ The modern definition of neurosecretion has evolved to include the release of an - The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells. As the cells adjacent to the lumen continue to divide, the migrating cells form a second layer around the original neural tube. This layer becomes progressively thicker as more cells are added to it from the germinal neuroepithelium. This new layer is called the mantle (or intermediate) zone, and the germinal epithelium is now called the ventricular zone (and, later, the ependyma)[NCBIBook:NBK10047] germinal neuroepithelial layer @@ -306368,14 +122882,14 @@ The modern definition of neurosecretion has evolved to include the release of an The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells. + MP:0004261 - http://www.ncbi.nlm.nih.gov/books/NBK10047 germinal neuroepithelial layer - http://orcid.org/0000-0002-6601-2165 + @@ -306444,7 +122958,7 @@ The modern definition of neurosecretion has evolved to include the release of an - BTO + BTO @@ -306463,7 +122977,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37440 - MA:th + MA:th @@ -306475,13 +122989,13 @@ The modern definition of neurosecretion has evolved to include the release of an biliary ductule - http://www.mondofacto.com/facts/dictionary?ductuli+biliferi + ductuli biliferi - http://www.mondofacto.com/facts/dictionary?ductuli+biliferi + @@ -306505,7 +123019,7 @@ The modern definition of neurosecretion has evolved to include the release of an terminal cholangiole - http://orcid.org/0000-0002-6601-2165 + @@ -306578,8 +123092,8 @@ The modern definition of neurosecretion has evolved to include the release of an The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium. + MP:0009689 - http://www.ncbi.nlm.nih.gov/books/NBK10047 @@ -306683,15 +123197,15 @@ The modern definition of neurosecretion has evolved to include the release of an The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer. + MP:0009690 - http://www.ncbi.nlm.nih.gov/books/NBK10047 neural tube intermediate zone + MP:0009690 - http://www.ncbi.nlm.nih.gov/books/NBK10047 @@ -306705,7 +123219,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -306750,8 +123264,8 @@ The modern definition of neurosecretion has evolved to include the release of an The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter. + MP:0009691 - http://www.ncbi.nlm.nih.gov/books/NBK10047 @@ -306798,11 +123312,12 @@ The modern definition of neurosecretion has evolved to include the release of an The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons. + + AAO:0010561 EFO:0001904 NCIT:C34111 UMLS:C1511061 - Wikipedia:Basal_plate_(neural_tube) neuronames:1372 basal plate basal plate of neural tube @@ -306831,9 +123346,9 @@ The modern definition of neurosecretion has evolved to include the release of an The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons. + + MP:0009693 - Wikipedia:Basal_plate_(neural_tube) - http://www.ncbi.nlm.nih.gov/books/NBK10047 @@ -306845,7 +123360,7 @@ The modern definition of neurosecretion has evolved to include the release of an basal plate of neural tube - Wikipedia:Basal_plate_(neural_tube) + @@ -306868,15 +123383,16 @@ The modern definition of neurosecretion has evolved to include the release of an The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout. UBERON:0006237 + + + EHDAA2:0000578 EHDAA:4778 EMAPA:16681 FMA:293101 NCIT:C34182 - SCTID:361486000 UMLS:C1517321 VHOG:0001319 - Wikipedia:Frontonasal_prominence embryonic frontonasal prominence uberon forebrain prominence @@ -306886,7 +123402,7 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0004066 frontonasal prominence - http://upload.wikimedia.org/wikipedia/commons/9/98/Gray44.png + http://upload.wikimedia.org/wikipedia/commons/9/98/Gray44.png @@ -306904,7 +123420,7 @@ The modern definition of neurosecretion has evolved to include the release of an embryonic frontonasal prominence - http://orcid.org/0000-0002-6601-2165 + @@ -306928,7 +123444,7 @@ The modern definition of neurosecretion has evolved to include the release of an prominentia frontonasalis - Wikipedia:Frontonasal_prominence + @@ -306937,6 +123453,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -306964,13 +123481,13 @@ The modern definition of neurosecretion has evolved to include the release of an The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it. Fusion of right and left medial nasal processes forms a primary palate rostrally and the nasal septum caudally. The incisive bone, including upper incisor teeth and the rostral up- per lip, are derived from the primary palate. The nasal septum consists of bone, cartilage, and a patch of soft tissue membrane that separates right & left halves of the nasal cavity. + + EHDAA2:0001076 EHDAA:4792 EMAPA:16808 FMA:295858 - SCTID:308877001 VHOG:0000804 - Wikipedia:Medial_nasal_prominence medial nasal process medial-nasal process prominentia nasalis medialis @@ -306980,7 +123497,7 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0004068 medial nasal prominence - http://upload.wikimedia.org/wikipedia/commons/8/85/Gray45.png + http://upload.wikimedia.org/wikipedia/commons/8/85/Gray45.png @@ -306991,7 +123508,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -307002,14 +123519,14 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it. + MP:0009903 - Wikipedia:Medial_nasal_prominence @@ -307027,20 +123544,20 @@ The modern definition of neurosecretion has evolved to include the release of an prominentia nasalis medialis - Wikipedia:Medial_nasal_prominence + medial nasal swelling - https://orcid.org/0000-0002-6601-2165 + nasomedial prominence - https://orcid.org/0000-0002-6601-2165 + @@ -307057,6 +123574,9 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart. + + + AAO:0010215 BTO:0001438 EMAPA:18415 @@ -307065,26 +123585,23 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000068 MESH:D014684 NCIT:C12817 - SCTID:244405007 + OpenCyc:Mx4rkJQ4U6gEEdudWQACs5b6Bw UMLS:C0042460 - Wikipedia:Venae_cavae uberon caval vein venae cavae UBERON:0004087 vena cava - http://upload.wikimedia.org/wikipedia/commons/3/35/Relations_of_the_aorta,_trachea,_esophagus_and_other_heart_structures.png - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb - https://upload.wikimedia.org/wikipedia/commons/7/7c/Heart_numlabels.png + http://upload.wikimedia.org/wikipedia/commons/3/35/Relations_of_the_aorta,_trachea,_esophagus_and_other_heart_structures.png + https://upload.wikimedia.org/wikipedia/commons/7/7c/Heart_numlabels.png Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart. - Wikipedia:Venae_cavae - http://orcid.org/0000-0002-6601-2165 + + @@ -307096,8 +123613,8 @@ The modern definition of neurosecretion has evolved to include the release of an venae cavae - Wikipedia:Venae_cavae - + + @@ -307132,7 +123649,7 @@ The modern definition of neurosecretion has evolved to include the release of an The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present. - http://orcid.org/0000-0002-6601-2165 + @@ -307150,13 +123667,13 @@ The modern definition of neurosecretion has evolved to include the release of an eye region - http://orcid.org/0000-0002-6601-2165 + orbital part of face - http://orcid.org/0000-0002-6601-2165 + @@ -307213,8 +123730,8 @@ The modern definition of neurosecretion has evolved to include the release of an The middle of the face including the nose and its associated bony structures[MW]. + HP:0000309 - http://www.merriam-webster.com/medical/midface @@ -307238,7 +123755,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -307253,7 +123770,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -307265,15 +123782,12 @@ The modern definition of neurosecretion has evolved to include the release of an Any tube, opening or passage that connects two distinct anatomical spaces. - - - FMA has both conduit and conduit space. In EHDAA2 this is a surface feature + + AEO:0000080 EHDAA2:0003080 FMA:242873 - SCTID:346902003 - Wikipedia:Foramen foramen foramina uberon @@ -307281,20 +123795,19 @@ The modern definition of neurosecretion has evolved to include the release of an ostia ostium UBERON:0004111 - anatomical conduit Any tube, opening or passage that connects two distinct anatomical spaces. - http://orcid.org/0000-0002-6601-2165 + FMA has both conduit and conduit space. In EHDAA2 this is a surface feature - FMA + FMA @@ -307306,14 +123819,14 @@ The modern definition of neurosecretion has evolved to include the release of an foramina - https://orcid.org/0000-0002-6601-2165 - + + ostia - + @@ -307354,7 +123867,7 @@ The modern definition of neurosecretion has evolved to include the release of an A vasculature that is part of a iris [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -307366,13 +123879,13 @@ The modern definition of neurosecretion has evolved to include the release of an iris vascular network - OBOL:automatic + OBOL:automatic vascular network of iris - OBOL:automatic + OBOL:automatic @@ -307392,6 +123905,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -307409,7 +123923,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical structure that develops (entirely or partially) from the endoderm. - https://orcid.org/0000-0002-6601-2165 + @@ -307429,6 +123943,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -307447,7 +123962,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical structure that develops (entirely or partially) from the mesoderm. - https://orcid.org/0000-0002-6601-2165 + @@ -307473,6 +123988,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -307491,7 +124007,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical structure that develops (entirely or partially) from the ectoderm. - https://orcid.org/0000-0002-6601-2165 + @@ -307521,6 +124037,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -307545,6 +124062,8 @@ The modern definition of neurosecretion has evolved to include the release of an Kidneys and gonads (of vertebrates) develop from adjacent tissues, and after the excretory or urinary ducts have developed, the reproductive system usually taps into them or their derivatives.[well established][VHOG] genitourinary urogenital + + AAO:0000624 BILA:0000122 BTO:0003091 @@ -307556,7 +124075,7 @@ The modern definition of neurosecretion has evolved to include the release of an GAID:362 MESH:D014566 NCIT:C12810 - SCTID:278861008 + OpenCyc:Mx4rQRpVMgAKEdyHxgDggVfs8g UMLS:C0042066 VHOG:0000286 XAO:0000140 @@ -307584,28 +124103,28 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000624 - AAO - AAO:EJS + AAO + AAO:EJS relationship type change: differentiates_from intermediate mesoderm (AAO:0010575) CHANGED TO: develops_from intermediate mesoderm (UBERON:0003064)[AAO] - 2012-06-20 + 2012-06-20 AAO:0000624 - AAO + AAO Kidneys and gonads (of vertebrates) develop from adjacent tissues, and after the excretory or urinary ducts have developed, the reproductive system usually taps into them or their derivatives.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000286 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.633 - http://bgee.unil.ch/ @@ -307676,13 +124195,13 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the layers of the myocardium. Example: compact layer, trabecular layer. - http://orcid.org/0000-0002-6601-2165 + EMAPA:37475 - MA:th + MA:th @@ -307747,10 +124266,10 @@ The modern definition of neurosecretion has evolved to include the release of an The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the the endocardium. Unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae of the zebrafish have more strut-like character, and are more uniform without apparent regional differences Hu et al. 2001.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005059 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -307762,13 +124281,13 @@ The modern definition of neurosecretion has evolved to include the release of an heart muscle trabeculae - + myocardial trabeculae carneae - + @@ -307834,7 +124353,7 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + @@ -307845,13 +124364,13 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + A myocardium trabecular layer that is part of a cardiac ventricle. - OBOL:automatic + OBOL:automatic @@ -307905,16 +124424,17 @@ The modern definition of neurosecretion has evolved to include the release of an The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]. (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles.[well established][VHOG] + + + AAO:0011039 EHDAA2:0001320 EMAPA:16540 FMA:293357 NCIT:C34236 - SCTID:362864008 TAO:0000050 UMLS:C0231106 VHOG:0000165 - Wikipedia:Optic_vesicles XAO:0000228 ZFA:0000050 uberon @@ -307927,7 +124447,7 @@ The modern definition of neurosecretion has evolved to include the release of an Genes: Six3, Pax6, Rx1 are expressed together in the tip of the neural plate [ISBN:9780878932504 "Developmental Biology"]. Development notes: During subsequent develop- ment, the optic vesicle invaginates and becomes a two-layered structure with an inner neural retina and outer retinal pigment epithelium. As soon as the developing optic vesicle makes contact with the overlying ectoderm, it induces the ectoderm to thicken and form the lens placode [PMID:16496288] optic vesicle - http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png + http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png @@ -307938,7 +124458,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -307960,24 +124480,24 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]. + GO:0003404 - Wikipedia:Optic_vesicles (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000165 - VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 - http://bgee.unil.ch/ + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 @@ -308002,7 +124522,7 @@ The modern definition of neurosecretion has evolved to include the release of an optic vesicles ZFA:0000050 - + @@ -308018,18 +124538,11 @@ The modern definition of neurosecretion has evolved to include the release of an - . salivary nucleus uberon UBERON:0004133 salivatory nucleus - - - - . - GO:0021751 - @@ -308042,6 +124555,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -308080,11 +124594,11 @@ The modern definition of neurosecretion has evolved to include the release of an (In vertebrates) The embryonic mesoderm is the source of both the cardiogenic plate, giving rise to the future myocardium as well as the endocardium that will line the system on the inner side.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000975 - VHOG + VHOG + PMID:15611355 Gittenberger-de Groot AC, Bartelings MM, Deruiter MC, Poelmann RE, Basics of cardiac development for the understanding of congenital heart malformations. Pediatric Research (2005) - http://bgee.unil.ch/ @@ -308158,7 +124672,7 @@ The modern definition of neurosecretion has evolved to include the release of an - https://orcid.org/0000-0003-3308-6245 + @@ -308184,7 +124698,7 @@ The modern definition of neurosecretion has evolved to include the release of an primary heart field - PMID:17276708 + XAO:0004185 @@ -308192,14 +124706,14 @@ The modern definition of neurosecretion has evolved to include the release of an FHF XAO:0004185 - + PHF XAO:0004185 - + @@ -308390,109 +124904,13 @@ The modern definition of neurosecretion has evolved to include the release of an cardiac outflow tract - PMID:20735616 + arterial (outflow) pole - PMID:20735616 - - - - - - - - - - - - - - - - - - - - - - - - - - - - The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. - the intraventricular conduction system from the bundle of His to the distal Purkinje fibers, which carries the impulse to the ventricles. - HPS - His-Purkinji network - VCS - ventricular conduction system - uberon - UBERON:0004146 - His-Purkinje system - - - - - - cjm - - - - - - - - - - - GO-def - - - - - - - - - - - GO - - - - - - - - - - - PMID:12626327 - PMID:21234997 - github:michaelerice - - - - - The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. - GO:0003164 - https://github.com/geneontology/go-ontology/issues/12451 - - - - - the intraventricular conduction system from the bundle of His to the distal Purkinje fibers, which carries the impulse to the ventricles. - http://medical-dictionary.thefreedictionary.com/His-Purkinje+system - - - - - HPS - + @@ -308537,15 +124955,17 @@ The modern definition of neurosecretion has evolved to include the release of an Vein of heart that drains the myocardium. + + + + EHDAA2:0004507 EMAPA:37137 FMA:12846 NCIT:C12878 NCIT:C12882 - SCTID:277726009 UMLS:C0226654 UMLS:C0226737 - Wikipedia:Coronary_circulation ZFA:0005814 galen:CoronaryVein cardiac vein @@ -308557,26 +124977,24 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0004148 cardiac vein - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb - FMA + FMA Vein of heart that drains the myocardium. - http://orcid.org/0000-0002-6601-2165 + EMAPA:37137 - MA:th + MA:th @@ -308606,19 +125024,19 @@ The modern definition of neurosecretion has evolved to include the release of an heart vein - OBOL:automatic + OBOL:automatic vein of heart - OBOL:automatic + OBOL:automatic coronary vein - Wikipedia:Coronary_circulation + @@ -308635,8 +125053,9 @@ The modern definition of neurosecretion has evolved to include the release of an A cardiac chamber surrounds an enclosed cavity within the heart. + FMA:7095 - SCTID:276456008 + OpenCyc:Mx4rmexpjPdAEduAAAAOpmP6tw chamber of heart heart chamber uberon @@ -308700,14 +125119,14 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium. + GO:0003342 - http://en.wiktionary.org/wiki/proepicardium @@ -308745,15 +125164,16 @@ The modern definition of neurosecretion has evolved to include the release of an In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart (of other tetrapods) is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes) Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG] The cranial part of the septum transversum gives rise to the central tendon of the diaphragm and is the origin of the myoblasts that invade the pleuroperitoneal folds resulting in the formation of the muscular diaphragm. The caudal part of the septum transversum is invaded by the hepatic diverticulum which divides within it to form the liver and thus gives rise to the ventral mesentery of the foregut. in EHDAA2 this is divided into mesenchymal portion and hepatic diverticulum + + + EHDAA2:0001829 EHDAA:736 EMAPA:16318 FMA:295593 NCIT:C34296 - SCTID:308819008 UMLS:C0231004 VHOG:0000019 - Wikipedia:Septum_transversum transverse septum uberon UBERON:0004161 @@ -308764,34 +125184,34 @@ The modern definition of neurosecretion has evolved to include the release of an A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]. + VHOG:0000019 - Wikipedia:Septum_transversum A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000019 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/transverse+septum + VHOG + + In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart (of other tetrapods) is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes) Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000019 - VHOG + VHOG + ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206 - http://bgee.unil.ch/ in EHDAA2 this is divided into mesenchymal portion and hepatic diverticulum - EHDAA2 + EHDAA2 @@ -308803,7 +125223,7 @@ The modern definition of neurosecretion has evolved to include the release of an transverse septum - https://orcid.org/0000-0002-6601-2165 + @@ -308845,8 +125265,8 @@ The modern definition of neurosecretion has evolved to include the release of an The external genitalia are the outer sex organs, such as the penis or vulva in mammals. + FMA:45643 - SCTID:362207005 external genitalia uberon external reproductive organ @@ -308892,11 +125312,11 @@ The modern definition of neurosecretion has evolved to include the release of an consider splitting out lymph organ, compare with lymph node the organs in which the formed elements of the blood and lymph are produced[http://encyclopedia2.thefreedictionary.com/Hematopoietic+Organs]. the FMA class 'lymphoid organ' is a general anatomical term + BTO:0004605 EMAPA:37665 FMA:7143 MA:0000747 - SCTID:361338006 haematological system organ haemopoietic system organ hematopoeitic organ @@ -308925,67 +125345,67 @@ The modern definition of neurosecretion has evolved to include the release of an the organs in which the formed elements of the blood and lymph are produced[http://encyclopedia2.thefreedictionary.com/Hematopoietic+Organs]. - http://encyclopedia2.thefreedictionary.com/Hematopoietic+Organs + the FMA class 'lymphoid organ' is a general anatomical term - FMA + FMA EMAPA:37665 - MA:th + MA:th haematological system organ - OBOL:automatic + OBOL:automatic haemopoietic system organ - OBOL:automatic + OBOL:automatic hematopoietic system organ - OBOL:automatic + OBOL:automatic organ of haematological system - OBOL:automatic + OBOL:automatic organ of haemopoietic system - OBOL:automatic + OBOL:automatic organ of hematopoietic system - OBOL:automatic + OBOL:automatic organ of organa haemopoietica - OBOL:automatic + OBOL:automatic organa haemopoietica organ - OBOL:automatic + OBOL:automatic @@ -309026,6 +125446,7 @@ The modern definition of neurosecretion has evolved to include the release of an The nonstriated, involuntary muscle tissue located in the wall of the aorta. + BTO:0001685 CALOHA:TS-0048 EFO:0002775 @@ -309046,7 +125467,7 @@ The modern definition of neurosecretion has evolved to include the release of an The nonstriated, involuntary muscle tissue located in the wall of the aorta. - MGI:csmith + MGI:csmith MP:0009865 @@ -309059,13 +125480,13 @@ The modern definition of neurosecretion has evolved to include the release of an aorta non-striated muscle - OBOL:automatic + OBOL:automatic aorta smooth muscle - OBOL:automatic + OBOL:automatic @@ -309164,19 +125585,19 @@ The modern definition of neurosecretion has evolved to include the release of an A nerve that is part of a back [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37268 - MA:th + MA:th nerve of back - OBOL:automatic + OBOL:automatic @@ -309238,7 +125659,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -309255,55 +125676,55 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition]. - OBOL:automatic + OBOL:automatic MA class may specifically mean muscle layer, but we treat as the sum of smooth muscle in both muscle layer and muscularis mucosa - MA + MA involuntary muscle of large intestine - OBOL:automatic + OBOL:automatic large intestine involuntary muscle - OBOL:automatic + OBOL:automatic large intestine non-striated muscle - OBOL:automatic + OBOL:automatic large intestine smooth muscle tissue - OBOL:automatic + OBOL:automatic non-striated muscle of large intestine - OBOL:automatic + OBOL:automatic smooth muscle of large intestine - OBOL:automatic + OBOL:automatic smooth muscle tissue of large intestine - OBOL:automatic + OBOL:automatic @@ -309349,6 +125770,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition]. MA class may specifically mean muscle layer, but we treat as the sum of smooth muscle in both muscle layer and muscularis mucosa + BTO:0000643 EMAPA:35441 EMAPA:35443 @@ -309392,13 +125814,13 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition]. - OBOL:automatic + OBOL:automatic MA class may specifically mean muscle layer, but we treat as the sum of smooth muscle in both muscle layer and muscularis mucosa - MA + MA @@ -309410,91 +125832,91 @@ The modern definition of neurosecretion has evolved to include the release of an bowel involuntary muscle - OBOL:automatic + OBOL:automatic bowel non-striated muscle - OBOL:automatic + OBOL:automatic bowel smooth muscle - OBOL:automatic + OBOL:automatic bowel smooth muscle tissue - OBOL:automatic + OBOL:automatic intestine involuntary muscle - OBOL:automatic + OBOL:automatic intestine non-striated muscle - OBOL:automatic + OBOL:automatic intestine smooth muscle tissue - OBOL:automatic + OBOL:automatic involuntary muscle of bowel - OBOL:automatic + OBOL:automatic involuntary muscle of intestine - OBOL:automatic + OBOL:automatic non-striated muscle of bowel - OBOL:automatic + OBOL:automatic non-striated muscle of intestine - OBOL:automatic + OBOL:automatic smooth muscle of bowel - OBOL:automatic + OBOL:automatic smooth muscle of intestine - OBOL:automatic + OBOL:automatic smooth muscle tissue of bowel - OBOL:automatic + OBOL:automatic smooth muscle tissue of intestine - OBOL:automatic + OBOL:automatic @@ -309568,97 +125990,97 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition]. - OBOL:automatic + OBOL:automatic involuntary muscle of stomach - OBOL:automatic + OBOL:automatic involuntary muscle of ventriculus - OBOL:automatic + OBOL:automatic non-striated muscle of stomach - OBOL:automatic + OBOL:automatic non-striated muscle of ventriculus - OBOL:automatic + OBOL:automatic smooth muscle of stomach - OBOL:automatic + OBOL:automatic smooth muscle of ventriculus - OBOL:automatic + OBOL:automatic smooth muscle tissue of stomach - OBOL:automatic + OBOL:automatic smooth muscle tissue of ventriculus - OBOL:automatic + OBOL:automatic stomach involuntary muscle - OBOL:automatic + OBOL:automatic stomach non-striated muscle - OBOL:automatic + OBOL:automatic stomach smooth muscle tissue - OBOL:automatic + OBOL:automatic ventriculus involuntary muscle - OBOL:automatic + OBOL:automatic ventriculus non-striated muscle - OBOL:automatic + OBOL:automatic ventriculus smooth muscle - OBOL:automatic + OBOL:automatic ventriculus smooth muscle tissue - OBOL:automatic + OBOL:automatic @@ -309718,7 +126140,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -309730,7 +126152,7 @@ The modern definition of neurosecretion has evolved to include the release of an smooth muscle of respiratory system - OBOL:automatic + OBOL:automatic @@ -309780,13 +126202,13 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic smooth muscle tissue of gastrointestinal system - OBOL:automatic + OBOL:automatic @@ -309846,151 +126268,151 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37394 - MA:th + MA:th anal part of perineum involuntary muscle - OBOL:automatic + OBOL:automatic anal part of perineum non-striated muscle - OBOL:automatic + OBOL:automatic anal part of perineum smooth muscle - OBOL:automatic + OBOL:automatic anal part of perineum smooth muscle tissue - OBOL:automatic + OBOL:automatic anal region involuntary muscle - OBOL:automatic + OBOL:automatic anal region non-striated muscle - OBOL:automatic + OBOL:automatic anal region smooth muscle tissue - OBOL:automatic + OBOL:automatic anal triangle involuntary muscle - OBOL:automatic + OBOL:automatic anal triangle non-striated muscle - OBOL:automatic + OBOL:automatic anal triangle smooth muscle - OBOL:automatic + OBOL:automatic anal triangle smooth muscle tissue - OBOL:automatic + OBOL:automatic involuntary muscle of anal part of perineum - OBOL:automatic + OBOL:automatic involuntary muscle of anal region - OBOL:automatic + OBOL:automatic involuntary muscle of anal triangle - OBOL:automatic + OBOL:automatic non-striated muscle of anal part of perineum - OBOL:automatic + OBOL:automatic non-striated muscle of anal region - OBOL:automatic + OBOL:automatic non-striated muscle of anal triangle - OBOL:automatic + OBOL:automatic smooth muscle of anal part of perineum - OBOL:automatic + OBOL:automatic smooth muscle of anal region - OBOL:automatic + OBOL:automatic smooth muscle of anal triangle - OBOL:automatic + OBOL:automatic smooth muscle tissue of anal part of perineum - OBOL:automatic + OBOL:automatic smooth muscle tissue of anal region - OBOL:automatic + OBOL:automatic smooth muscle tissue of anal triangle - OBOL:automatic + OBOL:automatic @@ -310035,49 +126457,49 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition]. - OBOL:automatic + OBOL:automatic involuntary muscle of lower respiratory tract - OBOL:automatic + OBOL:automatic lower respiratory tract involuntary muscle - OBOL:automatic + OBOL:automatic lower respiratory tract non-striated muscle - OBOL:automatic + OBOL:automatic lower respiratory tract smooth muscle tissue - OBOL:automatic + OBOL:automatic non-striated muscle of lower respiratory tract - OBOL:automatic + OBOL:automatic smooth muscle of lower respiratory tract - OBOL:automatic + OBOL:automatic smooth muscle tissue of lower respiratory tract - OBOL:automatic + OBOL:automatic @@ -310131,61 +126553,61 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA A portion of smooth muscle tissue that is part of a iris [Automatically generated definition]. - OBOL:automatic + OBOL:automatic involuntary muscle of iris - OBOL:automatic + OBOL:automatic iridial smooth muscle - http://orcid.org/0000-0002-6601-2165 + iris involuntary muscle - OBOL:automatic + OBOL:automatic iris non-striated muscle - OBOL:automatic + OBOL:automatic iris smooth muscle tissue - OBOL:automatic + OBOL:automatic non-striated muscle of iris - OBOL:automatic + OBOL:automatic smooth muscle of iris - OBOL:automatic + OBOL:automatic smooth muscle tissue of iris - OBOL:automatic + OBOL:automatic @@ -310224,7 +126646,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -310251,9 +126673,10 @@ The modern definition of neurosecretion has evolved to include the release of an Smooth muscle found within, and composing the majority of the wall of blood vessels. - Vascular smooth muscle contracts or relaxes to both change the volume of blood vessels and the local blood pressure, a mechanism that is responsible for the redistribution of the blood within the body to areas where it is needed (i.e. areas with temporarily enhanced oxygen consumption). Thus the main function of vascular smooth muscle tonus is to regulate the caliber of the blood vessels in the body. Excessive vasoconstriction leads to hypertension, while excessive vasodilation as in shock leads to hypotension. UBERON:0010508 + + BTO:0001431 CALOHA:TS-1107 EMAPA:35177 @@ -310262,7 +126685,6 @@ The modern definition of neurosecretion has evolved to include the release of an NCIT:C33853 TAO:0005321 UMLS:C1519956 - Wikipedia:Vascular_smooth_muscle ZFA:0005321 blood vessel involuntary muscle blood vessel non-striated muscle @@ -310275,7 +126697,6 @@ The modern definition of neurosecretion has evolved to include the release of an vascular smooth muscle tissue uberon UBERON:0004237 - blood vessel smooth muscle @@ -310283,7 +126704,7 @@ The modern definition of neurosecretion has evolved to include the release of an Smooth muscle found within, and composing the majority of the wall of blood vessels. - Wikipedia:Vascular_smooth_muscle + @@ -310295,43 +126716,43 @@ The modern definition of neurosecretion has evolved to include the release of an blood vessel involuntary muscle - OBOL:automatic + OBOL:automatic blood vessel non-striated muscle - OBOL:automatic + OBOL:automatic blood vessel smooth muscle tissue - OBOL:automatic + OBOL:automatic involuntary muscle of blood vessel - OBOL:automatic + OBOL:automatic non-striated muscle of blood vessel - OBOL:automatic + OBOL:automatic smooth muscle of blood vessel - OBOL:automatic + OBOL:automatic smooth muscle tissue of blood vessel - OBOL:automatic + OBOL:automatic @@ -310381,49 +126802,49 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition]. - OBOL:automatic + OBOL:automatic involuntary muscle of spleen - OBOL:automatic + OBOL:automatic non-striated muscle of spleen - OBOL:automatic + OBOL:automatic smooth muscle of spleen - OBOL:automatic + OBOL:automatic smooth muscle tissue of spleen - OBOL:automatic + OBOL:automatic spleen involuntary muscle - OBOL:automatic + OBOL:automatic spleen non-striated muscle - OBOL:automatic + OBOL:automatic spleen smooth muscle tissue - OBOL:automatic + OBOL:automatic @@ -310500,103 +126921,103 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition]. - OBOL:automatic + OBOL:automatic MA class may specifically mean muscle layer, but we treat as the sum of smooth muscle in both muscle layer and muscularis mucosa - MA + MA involuntary muscle of small bowel - OBOL:automatic + OBOL:automatic involuntary muscle of small intestine - OBOL:automatic + OBOL:automatic non-striated muscle of small bowel - OBOL:automatic + OBOL:automatic non-striated muscle of small intestine - OBOL:automatic + OBOL:automatic small bowel involuntary muscle - OBOL:automatic + OBOL:automatic small bowel non-striated muscle - OBOL:automatic + OBOL:automatic small bowel smooth muscle - OBOL:automatic + OBOL:automatic small bowel smooth muscle tissue - OBOL:automatic + OBOL:automatic small intestine involuntary muscle - OBOL:automatic + OBOL:automatic small intestine non-striated muscle - OBOL:automatic + OBOL:automatic small intestine smooth muscle tissue - OBOL:automatic + OBOL:automatic smooth muscle of small bowel - OBOL:automatic + OBOL:automatic smooth muscle of small intestine - OBOL:automatic + OBOL:automatic smooth muscle tissue of small bowel - OBOL:automatic + OBOL:automatic smooth muscle tissue of small intestine - OBOL:automatic + OBOL:automatic @@ -310624,6 +127045,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition]. + EMAPA:35373 MA:0001635 NCIT:C49483 @@ -310652,7 +127074,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -310664,85 +127086,85 @@ The modern definition of neurosecretion has evolved to include the release of an gall bladder involuntary muscle - OBOL:automatic + OBOL:automatic gall bladder non-striated muscle - OBOL:automatic + OBOL:automatic gall bladder smooth muscle - OBOL:automatic + OBOL:automatic gall bladder smooth muscle tissue - OBOL:automatic + OBOL:automatic gallbladder involuntary muscle - OBOL:automatic + OBOL:automatic gallbladder non-striated muscle - OBOL:automatic + OBOL:automatic involuntary muscle of gall bladder - OBOL:automatic + OBOL:automatic involuntary muscle of gallbladder - OBOL:automatic + OBOL:automatic non-striated muscle of gall bladder - OBOL:automatic + OBOL:automatic non-striated muscle of gallbladder - OBOL:automatic + OBOL:automatic smooth muscle of gall bladder - OBOL:automatic + OBOL:automatic smooth muscle of gallbladder - OBOL:automatic + OBOL:automatic smooth muscle tissue of gall bladder - OBOL:automatic + OBOL:automatic smooth muscle tissue of gallbladder - OBOL:automatic + OBOL:automatic @@ -310753,6 +127175,223 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition]. + + + BTO:0004401 + EMAPA:35195 + MA:0001840 + NCIT:C49213 + UMLS:C1707055 + bronchi involuntary muscle + bronchi non-striated muscle + bronchi smooth muscle + bronchi smooth muscle tissue + bronchial trunk involuntary muscle + bronchial trunk non-striated muscle + bronchial trunk smooth muscle + bronchial trunk smooth muscle tissue + bronchus involuntary muscle + bronchus non-striated muscle + bronchus smooth muscle tissue + involuntary muscle of bronchi + involuntary muscle of bronchial trunk + involuntary muscle of bronchus + non-striated muscle of bronchi + non-striated muscle of bronchial trunk + non-striated muscle of bronchus + smooth muscle of bronchi + smooth muscle of bronchial trunk + smooth muscle of bronchus + smooth muscle tissue of bronchi + smooth muscle tissue of bronchial trunk + smooth muscle tissue of bronchus + uberon + bronchial smooth muscle + UBERON:0004242 + + bronchus smooth muscle + + + + + A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C1707055 + ncithesaurus:Bronchus_Smooth_Muscle_Tissue + + + + + bronchi involuntary muscle + OBOL:automatic + + + + + bronchi non-striated muscle + OBOL:automatic + + + + + bronchi smooth muscle + OBOL:automatic + + + + + bronchi smooth muscle tissue + OBOL:automatic + + + + + bronchial trunk involuntary muscle + OBOL:automatic + + + + + bronchial trunk non-striated muscle + OBOL:automatic + + + + + bronchial trunk smooth muscle + OBOL:automatic + + + + + bronchial trunk smooth muscle tissue + OBOL:automatic + + + + + bronchus involuntary muscle + OBOL:automatic + + + + + bronchus non-striated muscle + OBOL:automatic + + + + + bronchus smooth muscle tissue + OBOL:automatic + + + + + involuntary muscle of bronchi + OBOL:automatic + + + + + involuntary muscle of bronchial trunk + OBOL:automatic + + + + + involuntary muscle of bronchus + OBOL:automatic + + + + + non-striated muscle of bronchi + OBOL:automatic + + + + + non-striated muscle of bronchial trunk + OBOL:automatic + + + + + non-striated muscle of bronchus + OBOL:automatic + + + + + smooth muscle of bronchi + OBOL:automatic + + + + + smooth muscle of bronchial trunk + OBOL:automatic + + + + + smooth muscle of bronchus + OBOL:automatic + + + + + smooth muscle tissue of bronchi + OBOL:automatic + + + + + smooth muscle tissue of bronchial trunk + OBOL:automatic + + + + + smooth muscle tissue of bronchus + OBOL:automatic + + + + + bronchial smooth muscle + EMAPA:35195 + + + + @@ -310792,55 +127431,55 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37708 - MA:th + MA:th involuntary muscle of outflow tract - OBOL:automatic + OBOL:automatic non-striated muscle of outflow tract - OBOL:automatic + OBOL:automatic outflow tract involuntary muscle - OBOL:automatic + OBOL:automatic outflow tract non-striated muscle - OBOL:automatic + OBOL:automatic outflow tract smooth muscle tissue - OBOL:automatic + OBOL:automatic smooth muscle of outflow tract - OBOL:automatic + OBOL:automatic smooth muscle tissue of outflow tract - OBOL:automatic + OBOL:automatic @@ -310884,13 +127523,13 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of the dorsal region of an animal. - http://orcid.org/0000-0002-6601-2165 + EMAPA:37248 - MA:th + MA:th @@ -310902,13 +127541,13 @@ The modern definition of neurosecretion has evolved to include the release of an bone of back - OBOL:automatic + OBOL:automatic dorsal region bone - http://orcid.org/0000-0002-6601-2165 + @@ -310960,13 +127599,13 @@ The modern definition of neurosecretion has evolved to include the release of an Any muscle organ that is part of a skin of body [Automatically generated definition]. - OBOL:automatic + OBOL:automatic in MA, the only skin muscle is arrector pili. The only integumental muscle is panniculus carnosus. In EMAPA, the arrector pili only - MA + MA @@ -310984,13 +127623,13 @@ The modern definition of neurosecretion has evolved to include the release of an muscle organ of skin - OBOL:automatic + OBOL:automatic skin muscle organ - OBOL:automatic + OBOL:automatic @@ -311028,19 +127667,19 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a back [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37243 - MA:th + MA:th blood vessel of back - OBOL:automatic + OBOL:automatic @@ -311089,71 +127728,71 @@ The modern definition of neurosecretion has evolved to include the release of an A myocardium that is part of a outflow tract [Automatically generated definition]. - OBOL:automatic + OBOL:automatic (...) (theme) is how the vertebrate cardiovascular system differs from that of the presumptive evolutionary chordate ancestor. (...) At best we can tell there are two essential new ingredients: (1) vertebrates all have a continuous endothelial lining to the heart and vessels and (2) vertebrates have developed a second chamber in the heart, one designed for generating high systemic blood pressure.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000603 - VHOG + VHOG + PMID:9187138 Fishman MC, Chien KR, Fashioning the vertebrate heart: earliest embryonic decisions. Development (1997) - http://bgee.unil.ch/ cardiac muscle of outflow tract - OBOL:automatic + OBOL:automatic heart muscle of outflow tract - OBOL:automatic + OBOL:automatic heart myocardium of outflow tract - OBOL:automatic + OBOL:automatic muscle of heart of outflow tract - OBOL:automatic + OBOL:automatic myocardium of outflow tract - OBOL:automatic + OBOL:automatic outflow tract cardiac muscle - OBOL:automatic + OBOL:automatic outflow tract heart muscle - OBOL:automatic + OBOL:automatic outflow tract heart myocardium - OBOL:automatic + OBOL:automatic outflow tract muscle of heart - OBOL:automatic + OBOL:automatic @@ -311191,19 +127830,19 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of connective tissue that is part of a back [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37256 - MA:th + MA:th mesenchyne of back - OBOL:automatic + OBOL:automatic @@ -311242,19 +127881,19 @@ The modern definition of neurosecretion has evolved to include the release of an A pericardium that is part of a outflow tract [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37707 - MA:th + MA:th pericardium of outflow tract - OBOL:automatic + OBOL:automatic @@ -311291,6 +127930,7 @@ The modern definition of neurosecretion has evolved to include the release of an AAO:0000156 EMAPA:35335 MA:0000271 + OpenCyc:Mx8Ngx4rwKSh9pwpEbGdrcN5Y29ycB4rvViTvpwpEbGdrcN5Y29ycB4rvYA8cJwpEbGdrcN5Y29ycA uberon UBERON:0004277 @@ -311305,13 +127945,13 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA A muscle that is part of the eye region. - OBOL:automatic + OBOL:automatic @@ -311335,9 +127975,10 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body. - Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.[VSAO] skeletal + + AEO:0000168 EHDAA2:0001843 EHDAA:5047 @@ -311348,9 +127989,8 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000032 MESH:D012863 MIAA:0000032 - SCTID:361378004 + OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA VSAO:0000026 - Wikipedia:Skeleton XAO:0004053 galen:Skeleton set of all bones @@ -311358,7 +127998,6 @@ The modern definition of neurosecretion has evolved to include the release of an uberon UBERON:0004288 - skeleton @@ -311374,9 +128013,9 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000026 - VSAO + VSAO GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 @@ -311386,6 +128025,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -311405,6 +128045,7 @@ The modern definition of neurosecretion has evolved to include the release of an Portion of somites that gives rise to dermis and muscles.[AAO] all but the sclerotome of a mesodermal somite; the primordium of skeletal muscle and, perhaps, of the dermis. Thus, representatives of the agnathan vertebrates, chondrichthyans, and sarcopterygians all have a layer of undifferentiated cells external to the embryonic myotome. In the amniotes, this external cell layer is the dermomyotome. The simplest interpretation of the similar position, morphology, and lack of myosin labeling is that a dermomyotome epithelium is a shared, ancestral vertebrate characteristic.[well established][VHOG] + AAO:0010572 AEO:0000214 EHDAA2:0003259 @@ -311425,13 +128066,13 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO - AEO + AEO @@ -311442,8 +128083,8 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 - ZFA + EHDAA2 + ZFA @@ -311455,41 +128096,41 @@ The modern definition of neurosecretion has evolved to include the release of an Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis. Within the dermomyotome there is also a medio-lateral difference. The central region makes dermis, the mesenchymal connective tissue of the back skin. The medial region (closest to neural tube) makes epaxial muscle, and the lateral region (furthest from neural tube) makes hypaxial muscle[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768]. - http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768 + Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001513 - TAO - ZFIN:curator + TAO + ZFIN:curator Portion of somites that gives rise to dermis and muscles.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010572 - AAO - AAO:EJS + AAO + AAO:EJS all but the sclerotome of a mesodermal somite; the primordium of skeletal muscle and, perhaps, of the dermis. - http://medical-dictionary.thefreedictionary.com/dermomyotome + Thus, representatives of the agnathan vertebrates, chondrichthyans, and sarcopterygians all have a layer of undifferentiated cells external to the embryonic myotome. In the amniotes, this external cell layer is the dermomyotome. The simplest interpretation of the similar position, morphology, and lack of myosin labeling is that a dermomyotome epithelium is a shared, ancestral vertebrate characteristic.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000676 - VHOG + VHOG + DOI:10.1111/j.1525-142X.2006.05079.x Devoto SH, Stoiber W, Hammond CL, Steinbacher P, Haslett JR, Barresi MJF, Patterson SE, Adiarte EG and Hughes SM, Generality of vertebrate developmental patterns: evidence for a dermomyotome in fish. Evolution and Development (2006) - http://bgee.unil.ch/ @@ -311508,7 +128149,7 @@ The modern definition of neurosecretion has evolved to include the release of an dermomyotomes VHOG:0000676 - + @@ -311548,7 +128189,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -311560,10 +128201,10 @@ The modern definition of neurosecretion has evolved to include the release of an The migrating myocardial precursors of the heart rudiment form a cone like structure between 19.5hpf and 22hpf, and eventually telescope out into the primitive heart tube at 24hpf. Stainier 2001.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000115 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -311605,9 +128246,9 @@ The modern definition of neurosecretion has evolved to include the release of an Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart. It is not a true skeleton, but it does provide structure and support for the heart, as well as isolating the atria from the ventricles. This allows the AV node and AV bundle to delay the wave of depolarisation such that the atria can contract and assist in ventricular filling before the ventricles themselves depolarise and contract (the AV bundle is the only part of the conduction system that passes from the atria to the ventricles in a normal heart). It also allows the valves (bicuspid, tricuspid, semilunar) to keep open by giving them structural support[WP] + EMAPA:36645 FMA:9496 - Wikipedia:Cardiac_skeleton cardiac fibrous skeleton fibrous skeleton of heart heart fibrous skeleton @@ -311620,14 +128261,14 @@ The modern definition of neurosecretion has evolved to include the release of an trigonum fibrosum sinistrum cordis UBERON:0004292 cardiac skeleton - http://upload.wikimedia.org/wikipedia/commons/5/50/Gray495.png + http://upload.wikimedia.org/wikipedia/commons/5/50/Gray495.png Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart. + GO:0003204 - Wikipedia:Cardiac_skeleton @@ -311651,35 +128292,35 @@ The modern definition of neurosecretion has evolved to include the release of an anulus fibrosus dexter cordis - Wikipedia:Cardiac_skeleton + anulus fibrosus sinister cordis - Wikipedia:Cardiac_skeleton + trigona fibrosa - Wikipedia:Cardiac_skeleton + trigonum fibrosum dextrum cordis - Wikipedia:Cardiac_skeleton + trigonum fibrosum sinistrum cordis - Wikipedia:Cardiac_skeleton + @@ -311719,19 +128360,19 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37573 - MA:th + MA:th smooth muscle tissue of blood vessel of respiratory system - OBOL:automatic + OBOL:automatic @@ -311780,7 +128421,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -311791,7 +128432,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -311802,7 +128443,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -311814,26 +128455,26 @@ The modern definition of neurosecretion has evolved to include the release of an The outer cellular layer of the mammalian blastocyst. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Vertebrates:_Comparative_Anatomy, p.750, see_Kardong_KV][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000979 - VHOG - http://bgee.unil.ch/ + VHOG + (...) the trophoblast develops rapidly so that contact may be made with the maternal uterine tissues when conditions are appropriate. We have here an excellent example of an embryonic adaptation, the development of a structure never present in either adult or embryo of 'lower' vertebrates.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000979 - VHOG + VHOG + ISBN:978-0721676685 Romer AS, Parsons TS, Vertebrate body (1977) p.105-106 - http://bgee.unil.ch/ BTO has this has part of the trophoblast - BTO + BTO @@ -311870,6 +128511,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -311914,12 +128556,13 @@ The modern definition of neurosecretion has evolved to include the release of an relationship loss: subclass proliferative region (TAO:0000098)[TAO] The AER of tetrapods regresses after specification of skeletal progenitors, the AER of teleosts form an elongating fin fold maintaining mesenchyme in plastic proliferating state; maintaining expression of A-P axis genes; interacting with D-V proteins. Genes: AER induced by Fgf10 in mesenchyme. AER secretes Fgf8, which stimulates mitosis in the mesenchyme causing Fgf10 production - positive feedback loop + + AAO:0010760 EMAPA:32744 NCIT:C34109 TAO:0002146 UMLS:C1516037 - Wikipedia:Apical_ectodermal_ridge XAO:0004121 ZFA:0001702 apical epidermal ridge @@ -311929,46 +128572,46 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0004356 apical ectodermal ridge - http://upload.wikimedia.org/wikipedia/commons/5/56/Limbbuddiagram.jpg + http://upload.wikimedia.org/wikipedia/commons/5/56/Limbbuddiagram.jpg Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. + MP:0001676 - Wikipedia:Apical_ectodermal_ridge Distal ectodermal thickening which forms along the anterior-posterior limb axis. Signaling from this region influences proximal-distal patterning of the limb. Structure is missing in some lineages (salamanders, Eleutherodactylus coqui) however morphologically their indistinct distal ectoderm may still be involved in signaling.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010760 - AAO - AAO:EJS + AAO + AAO:EJS Proliferative region that is part of the developing fin fold or fin.[TAO] - 2012-08-14 + 2012-08-14 TAO:0002146 - TAO - ZFIN:curator + TAO + ZFIN:curator relationship loss: subclass proliferative region (TAO:0000098)[TAO] - 2012-08-14 + 2012-08-14 TAO:0002146 - TAO + TAO The AER of tetrapods regresses after specification of skeletal progenitors, the AER of teleosts form an elongating fin fold - PMID:20574421 + @@ -311992,7 +128635,7 @@ The modern definition of neurosecretion has evolved to include the release of an crista ectodermalis apicalis - Wikipedia:Apical_ectodermal_ridge + @@ -312043,19 +128686,19 @@ The modern definition of neurosecretion has evolved to include the release of an An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. + ISBN:9780878932504 MP:0005650 - https://orcid.org/0000-0002-6601-2165 The tetrapod limb is derived from a posterior part of the fin endoskeleton of elasmobranchs and basal bony fish, the so-called metapterygium, a series of endoskeletal elements that is the first to form in the developing paired fins. (...) In addition, there is an independent endoskeletal element called the protopterygium that develops anterior to the metapterygium in many basal fishes (e.g., the bichir and sturgeon). Teleosts have lost the metapterygium whereas the sarcopterygians, on the other hand, have lost the protopterygium. Sarcopterygians thus develop all their endoskeletal structures from the metapterygium and consequently the tetrapod limb skeleton is derived from the metapterygium.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001258 - VHOG + VHOG + DOI:10.1002/jez.1100 Wagner GP, Chiu C, The tetrapod limb: A hypothesis on its origin. J Exp Zool (Mol Dev Evol) (2001) - http://bgee.unil.ch/ @@ -312081,6 +128724,9 @@ The modern definition of neurosecretion has evolved to include the release of an the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel's cartilage, trigeminal nerve, and maxillary artery A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG] 1 + + + AAO:0010364 CALOHA:TS-2089 EHDAA2:0000006 @@ -312089,11 +128735,9 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:293019 MFMO:0000095 NCIT:C34175 - SCTID:308767008 TAO:0001595 UMLS:C1517197 VHOG:0000296 - Wikipedia:First_pharyngeal_arch XAO:0000097 ZFA:0001612 1st pharyngeal arch @@ -312112,21 +128756,21 @@ The modern definition of neurosecretion has evolved to include the release of an pharyngeal arch 1 - http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png + http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries. - http://orcid.org/0000-0002-6601-2165 + The first of the series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010364 - AAO + AAO XAO:EJS @@ -312139,11 +128783,11 @@ The modern definition of neurosecretion has evolved to include the release of an A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000296 - VHOG + VHOG + DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) - http://bgee.unil.ch/ @@ -312191,7 +128835,7 @@ The modern definition of neurosecretion has evolved to include the release of an arcus pharyngeus primus - Wikipedia:First_pharyngeal_arch + @@ -312249,6 +128893,8 @@ The modern definition of neurosecretion has evolved to include the release of an Number varies - Lampreys have 8, hagfishes 15; only up to 6 appear in embryonic development in most gnathostome fishes and all tetrapods The third, fourth, and sixth arches, along with the seventh intersegmental arteries and the left dorsal aorta, are the primary contributors to the normal aortic arch and its major thoracic branches UBERON:0004342 + + AAO:0010414 EFO:0003695 EHDAA2:0000186 @@ -312259,7 +128905,6 @@ The modern definition of neurosecretion has evolved to include the release of an TAO:0005004 UMLS:C0003489 VHOG:0000122 - Wikipedia:Aortic_arches XAO:0000341 ZFA:0005004 PAA @@ -312282,13 +128927,13 @@ The modern definition of neurosecretion has evolved to include the release of an pharyngeal arch artery - http://upload.wikimedia.org/wikipedia/commons/8/84/Gray473.png + http://upload.wikimedia.org/wikipedia/commons/8/84/Gray473.png - ZFA + ZFA @@ -312299,7 +128944,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -312322,21 +128967,21 @@ The modern definition of neurosecretion has evolved to include the release of an Paired vessels arching from the ventral to the dorsal aorta through the pharyngeal arches. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000122 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/aortic+arches + VHOG + + When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000122 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 - http://bgee.unil.ch/ @@ -312349,7 +128994,7 @@ The modern definition of neurosecretion has evolved to include the release of an PAA MP:0002672 - + @@ -312362,14 +129007,14 @@ The modern definition of neurosecretion has evolved to include the release of an aortic arches ZFA:0005004 - + branchial aortic arches ZFIN:ZDB-PUB-080512-6 - + @@ -312394,7 +129039,7 @@ The modern definition of neurosecretion has evolved to include the release of an a. arcuum pharyngeorum - Wikipedia:Aortic_arches + @@ -312407,7 +129052,7 @@ The modern definition of neurosecretion has evolved to include the release of an arteriae arcuum pharyngeorum - Wikipedia:Aortic_arches + @@ -312416,13 +129061,13 @@ The modern definition of neurosecretion has evolved to include the release of an branchial aortic arches ZFA:0005004 ZFIN:ZDB-PUB-080512-6 - + pharyngeal arch arteries - + @@ -312433,49 +129078,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta. - derivative of the early postimplantation trophoblast, which probably gives rise to the spongiotrophoblast. - BTO:0001715 - EMAPA:16059 - epamniotic cone - placenta - ectoplacental cone - uberon - UBERON:0004364 - - ectoplacental cone - - - - - Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta. - MP:0001717 - PMID:19829370 - - - - - derivative of the early postimplantation trophoblast, which probably gives rise to the spongiotrophoblast. - PMID:19829370 - - - - @@ -312514,7 +129116,7 @@ The modern definition of neurosecretion has evolved to include the release of an Blood vessel that is connected to the yolk sac. - http://orcid.org/0000-0002-6601-2165 + @@ -312578,16 +129180,17 @@ The modern definition of neurosecretion has evolved to include the release of an Acellular anatomical structure composed of collagen, Descemet's membrane is secreted as a basement membrane of the corneal endothelium. Located between the stroma and the corneal endothelium, it is approximately 0.15 micrometer thick at 6 months post-fertilization.[ZFIN] + + + EMAPA:18804 FMA:58309 GAID:894 MA:0001246 MESH:D003886 NCIT:C32454 - SCTID:281076002 TAO:0002157 UMLS:C0011665 - Wikipedia:Descemet%27s_membrane ZFA:0001686 Descemet membrane Descemet's posterior elastic lamina @@ -312619,14 +129222,14 @@ The modern definition of neurosecretion has evolved to include the release of an - lexical + lexical A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP]. + MP:0004285 - https://github.com/obophenotype/uberon/issues/15 @@ -312635,8 +129238,8 @@ The modern definition of neurosecretion has evolved to include the release of an 2016-05-01 TAO:0002157 ZFIN + ZFIN:ZDB-PUB-061010-3 - https://orcid.org/0000-0001-9114-8737 @@ -312661,7 +129264,7 @@ The modern definition of neurosecretion has evolved to include the release of an lamina limitans posterior corneae FMA:58309 - FMA:TA + FMA:TA @@ -312726,13 +129329,14 @@ The modern definition of neurosecretion has evolved to include the release of an A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane. Acellular anatomical structure that is the zone of collagen fibers adjacent the basement membrane of the corneal epithelium.[TAO] Compared to terrestial animals, the cornea of zebrafish is relatively flat. It consists of nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals + + + FMA:58273 MA:0001240 NCIT:C32226 - SCTID:281075003 TAO:0002155 UMLS:C0229127 - Wikipedia:Bowman%27s_membrane ZFA:0001684 Bowman's anterior elastic lamina Bowman's layer @@ -312754,7 +129358,7 @@ The modern definition of neurosecretion has evolved to include the release of an - lexical + lexical @@ -312766,9 +129370,9 @@ The modern definition of neurosecretion has evolved to include the release of an Acellular anatomical structure that is the zone of collagen fibers adjacent the basement membrane of the corneal epithelium.[TAO] - 2012-08-14 + 2012-08-14 TAO:0002155 - TAO + TAO ZFIN:ZDB-PUB-061010-3 @@ -312824,14 +129428,14 @@ The modern definition of neurosecretion has evolved to include the release of an lamina limitans anterior corneae FMA:58273 - FMA:TA + FMA:TA Reichert's membrane - http://sourceforge.net/tracker/?func=detail&aid=2956371&group_id=76834&atid=974957 + @@ -312871,7 +129475,7 @@ The modern definition of neurosecretion has evolved to include the release of an Vascular network that is connected to the yolk sac. - Wikipedia:Vitelline_circulation + uberon omphalomesenteric system vitelline bloos vessel system @@ -312884,25 +129488,25 @@ The modern definition of neurosecretion has evolved to include the release of an Vascular network that is connected to the yolk sac. - http://orcid.org/0000-0002-6601-2165 + omphalomesenteric system - https://orcid.org/0000-0002-6601-2165 + vitelline bloos vessel system - https://orcid.org/0000-0002-6601-2165 + vitelline system - https://orcid.org/0000-0002-6601-2165 + @@ -312948,7 +129552,7 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of an appendage [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -313004,13 +129608,13 @@ The modern definition of neurosecretion has evolved to include the release of an it's not clear if the XAO class belongs here or below - XAO + XAO EMAPA:37722 - MA:th + MA:th @@ -313036,6 +129640,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -313050,6 +129655,7 @@ The modern definition of neurosecretion has evolved to include the release of an An embryo at the neurula stage. UBERON:0007013 + BILA:0000061 BTO:0001766 NCIT:C34229 @@ -313063,7 +129669,7 @@ The modern definition of neurosecretion has evolved to include the release of an An embryo at the neurula stage. - http://orcid.org/0000-0002-6601-2165 + @@ -313110,7 +129716,7 @@ The modern definition of neurosecretion has evolved to include the release of an Sum of all sensory systems in an organism. - http://orcid.org/0000-0002-6601-2165 + @@ -313184,7 +129790,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any collection of skeletal muscles that is part of a head [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -313209,7 +129815,7 @@ The modern definition of neurosecretion has evolved to include the release of an musculi capitis FMA:71287 - FMA:TA + FMA:TA @@ -313261,19 +129867,19 @@ The modern definition of neurosecretion has evolved to include the release of an Any collection of muscles that is part of a thorax [Automatically generated definition]. - OBOL:automatic + OBOL:automatic BTO and FMA do not mean precisely the same thing here. BTO thorax muscle is a pectoral muscle or diaphragm - BTO + BTO EMAPA:37260 - MA:th + MA:th @@ -313292,7 +129898,7 @@ The modern definition of neurosecretion has evolved to include the release of an musculi thoracis FMA:71293 - FMA:TA + FMA:TA @@ -313324,7 +129930,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -313352,7 +129958,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any collection of muscles that is part of a neck [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -313377,7 +129983,7 @@ The modern definition of neurosecretion has evolved to include the release of an musculi cervicis FMA:71290 - FMA:TA + FMA:TA @@ -313385,7 +129991,7 @@ The modern definition of neurosecretion has evolved to include the release of an musculi colli FMA:71290 - FMA:TA + FMA:TA @@ -313480,7 +130086,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any collection of muscles that is part of a back [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -313499,7 +130105,7 @@ The modern definition of neurosecretion has evolved to include the release of an musculi dorsi FMA:71291 - FMA:TA + FMA:TA @@ -313559,13 +130165,13 @@ The modern definition of neurosecretion has evolved to include the release of an Any collection of muscles that is part of a pelvic girdle [Automatically generated definition]. - OBOL:automatic + OBOL:automatic we merge two FMA classes here - FMA + FMA @@ -313656,13 +130262,13 @@ The modern definition of neurosecretion has evolved to include the release of an A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles. - https://orcid.org/0000-0002-6601-2165 + EMAPA:37857 - MA:th + MA:th @@ -313730,13 +130336,13 @@ The modern definition of neurosecretion has evolved to include the release of an Any collection of muscles that is part of a face. - OBOL:automatic + OBOL:automatic entire facial musculature - https://orcid.org/0000-0002-6601-2165 + @@ -313755,7 +130361,7 @@ The modern definition of neurosecretion has evolved to include the release of an musculi faciei FMA:71288 - FMA:TA + FMA:TA @@ -313812,7 +130418,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any collection of muscles that is part of a trunk [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -313877,7 +130483,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -313948,31 +130554,31 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition]. - OBOL:automatic + OBOL:automatic interatrial septum cardiac muscle tissue - http://orcid.org/0000-0002-6601-2165 + interatrial septum heart muscle - http://orcid.org/0000-0002-6601-2165 + interatrial septum muscle - http://orcid.org/0000-0002-6601-2165 + interatrial septum myocardium - http://orcid.org/0000-0002-6601-2165 + @@ -314012,31 +130618,31 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition]. - OBOL:automatic + OBOL:automatic cardiac septum cardiac muscle tissue - http://orcid.org/0000-0002-6601-2165 + cardiac septum heart muscle - http://orcid.org/0000-0002-6601-2165 + cardiac septum muscle - http://orcid.org/0000-0002-6601-2165 + cardiac septum myocardium - http://orcid.org/0000-0002-6601-2165 + @@ -314081,13 +130687,13 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -314124,7 +130730,91 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition]. - OBOL:automatic + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition]. + + FMA:261045 + FMA:261081 + smooth muscle tissue of lobular bronchiole + uberon + UBERON:0004515 + + smooth muscle tissue of bronchiole + + + + + A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition]. + OBOL:automatic + + + + + smooth muscle tissue of lobular bronchiole + FMA:261081 + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition]. + + FMA:261051 + uberon + UBERON:0004516 + + smooth muscle tissue of terminal bronchiole + + + + + A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition]. + OBOL:automatic @@ -314144,6 +130834,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + @@ -314161,7 +130857,7 @@ The modern definition of neurosecretion has evolved to include the release of an A muscle that is attached to a vertebra of the vertebral column. - https://orcid.org/0000-0002-6601-2165 + @@ -314186,6 +130882,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -314204,7 +130901,7 @@ The modern definition of neurosecretion has evolved to include the release of an A vasculature that is part of a muscle organ [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -314246,117 +130943,7 @@ The modern definition of neurosecretion has evolved to include the release of an A vasculature that is part of a musculoskeletal system [Automatically generated definition]. - OBOL:automatic - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A portion of trabecula carnea cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]. - FMA:84429 - uberon - UBERON:0004525 - cardiac muscle tissue of trabecula carnea of right ventricle - - - - - - - - - - - true - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships - - - - - A portion of trabecula carnea cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]. - OBOL:automatic - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A portion of trabecula carnea cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]. - FMA:84430 - uberon - UBERON:0004526 - cardiac muscle tissue of trabecula carnea of left ventricle - - - - - - - - - - - true - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships - - - - - A portion of trabecula carnea cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -314383,8 +130970,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -314405,8 +130992,9 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that has as its parts the heart and blood vessels. we treat cardiovascular as part of circulatory system, with the latter including other kinds of circulation, including lymph. - The vessels of the cardiovascular system are as varied as the diverse organs they supply. However, these variations are based on modifications of a fundamental plan of organization common to vertebrates.[well established][VHOG] + + AAO:0011001 BILA:0000016 BTO:0000088 @@ -314424,7 +131012,7 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D002319 MIAA:0000016 NCIT:C12686 - SCTID:278198007 + OpenCyc:Mx4rvVjzG5wpEbGdrcN5Y29ycA TAO:0000010 UMLS:C0007226 VHOG:0000302 @@ -314437,7 +131025,6 @@ The modern definition of neurosecretion has evolved to include the release of an Herz und Gefaesssystem UBERON:0004535 - @@ -314453,11 +131040,11 @@ The modern definition of neurosecretion has evolved to include the release of an The vessels of the cardiovascular system are as varied as the diverse organs they supply. However, these variations are based on modifications of a fundamental plan of organization common to vertebrates.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000302 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.451 - http://bgee.unil.ch/ @@ -314494,7 +131081,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -314521,14 +131108,12 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0004537 blood vasculature - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb A vascular network consisting of blood vessels. - https://orcid.org/0000-0002-6601-2165 + @@ -314563,11 +131148,11 @@ The modern definition of neurosecretion has evolved to include the release of an An eye that is part of a left side of organism [Automatically generated definition]. https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern + EMAPA:37362 FMA:12515 MA:0002949 NCIT:C119334 - SCTID:362503005 left eyeball left orbital part of face left orbital region @@ -314575,22 +131160,18 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0004548 left eye - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_L.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Eye_L.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-eye-l.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-eye-l.glb An eye that is part of a left side of organism [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37362 - MA:th + MA:th @@ -314637,11 +131218,11 @@ The modern definition of neurosecretion has evolved to include the release of an An eye that is part of a right side of organism [Automatically generated definition]. https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern + EMAPA:37363 FMA:12514 MA:0002950 NCIT:C119333 - SCTID:362502000 right eyeball right orbital part of face right orbital region @@ -314649,22 +131230,18 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0004549 right eye - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_R.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Eye_R.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-eye-r.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-eye-r.glb An eye that is part of a right side of organism [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37363 - MA:th + MA:th @@ -314698,8 +131275,8 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart. + FMA:45623 - Wikipedia:Systemic_circulation#Arteries systemic arterial circulatory system uberon UBERON:0004571 @@ -314716,8 +131293,8 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart. - Wikipedia:Systemic_circulation#Arteries - http://orcid.org/0000-0002-6601-2165 + + @@ -314731,7 +131308,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -314746,19 +131323,17 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the cardiovascular system consisting of all arteries. - The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + BTO:0004690 EHDAA2:0000143 EHDAA:396 EMAPA:16201 EMAPA:16371 MA:0002719 - SCTID:362030008 VHOG:0000273 uberon UBERON:0004572 - arterial system @@ -314766,7 +131341,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -314777,23 +131352,23 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 The part of the cardiovascular system consisting of all arteries. - https://orcid.org/0000-0002-6601-2165 + The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000273 - VHOG + VHOG + DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2005) - http://bgee.unil.ch/ @@ -314820,14 +131395,12 @@ The modern definition of neurosecretion has evolved to include the release of an An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart. - + EMAPA:37126 FMA:66464 - Wikipedia:Artery#Systemic_arteries systemic arterial subtree uberon UBERON:0004573 - systemic artery @@ -314835,14 +131408,14 @@ The modern definition of neurosecretion has evolved to include the release of an An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart. - Wikipedia:Artery#Systemic_arteries - http://orcid.org/0000-0002-6601-2165 + + EMAPA:37126 - MA:th + MA:th @@ -314867,8 +131440,8 @@ The modern definition of neurosecretion has evolved to include the release of an In human anatomy, the systemic venous system refers to veins that drain into the right atrium without passing through two vascular beds (i.e. they originate from a set of capillaries and do not pass through a second set of capillaries before reaching the right side of the heart). The term systemic venous system is often used to differentiate veins from veins that drain the pulmonary system (the pulmonary venous system) and veins that drain the digestive tract (the portal venous system). Large veins that are considered part of the systemic venous system are the: Superior vena cava; Inferior vena cava[WP] Subdivision of cardiovascular system which has as its parts the right side of heart, the superior vena cava and the inferior vena cava[FMA] The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + FMA:45626 - Wikipedia:Systemic_venous_system systemic venous circulatory system uberon UBERON:0004581 @@ -314878,14 +131451,14 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the venous system that drains the general body tissues[Kardong]. - ISBN:0073040584 - Wikipedia:Systemic_venous_system + + ISBN:0073040584 In human anatomy, the systemic venous system refers to veins that drain into the right atrium without passing through two vascular beds (i.e. they originate from a set of capillaries and do not pass through a second set of capillaries before reaching the right side of the heart). The term systemic venous system is often used to differentiate veins from veins that drain the pulmonary system (the pulmonary venous system) and veins that drain the digestive tract (the portal venous system). Large veins that are considered part of the systemic venous system are the: Superior vena cava; Inferior vena cava[WP] - Wikipedia:Systemic_venous_system + @@ -314898,11 +131471,11 @@ The modern definition of neurosecretion has evolved to include the release of an The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000277 - VHOG + VHOG + DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2005) - http://bgee.unil.ch/ @@ -314916,7 +131489,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -314925,44 +131498,43 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions. - The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + + BTO:0004692 EHDAA2:0002171 EHDAA:486 EMAPA:16240 MA:0002720 NCIT:C33858 - SCTID:362060003 UMLS:C1267406 VHOG:0000277 vein system uberon UBERON:0004582 - venous system - MA + MA The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions. - https://orcid.org/0000-0002-6601-2165 + The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000277 - VHOG + VHOG + DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2005) - http://bgee.unil.ch/ @@ -314979,10 +131551,11 @@ The modern definition of neurosecretion has evolved to include the release of an A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. FMA class is not a subtype of muscle + + FMA:75004 NCIT:C28381 UMLS:C1409894 - Wikipedia:Sphincter sphincter uberon circular muscle @@ -314993,13 +131566,13 @@ The modern definition of neurosecretion has evolved to include the release of an A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. - Wikipedia:Sphincter + FMA class is not a subtype of muscle - FMA + FMA @@ -315032,6 +131605,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart. + BTO:0000766 CALOHA:TS-2155 EMAPA:35176 @@ -315050,7 +131624,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart. - https://orcid.org/0000-0002-6601-2165 + @@ -315087,13 +131661,14 @@ The modern definition of neurosecretion has evolved to include the release of an The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein. should not be confused with the anatomic lobes of the liver (caudate lobe, quadrate lobe, left lobe, and right lobe), or any of the functional lobe classification systems.[WP] + + + EMAPA:35499 FMA:14471 MA:0002494 NCIT:C32732 - SCTID:362194004 UMLS:C0227518 - Wikipedia:Lobules_of_liver hepatic lobule lobuli hepatici lobulus hepaticus @@ -315109,7 +131684,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -315120,14 +131695,14 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA - MA + FMA + MA The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0008987 @@ -315146,7 +131721,7 @@ The modern definition of neurosecretion has evolved to include the release of an lobuli hepatici - + @@ -315159,14 +131734,14 @@ The modern definition of neurosecretion has evolved to include the release of an lobules of liver - Wikipedia:Lobules_of_liver - + + lobuli hepatis - Wikipedia:Lobules_of_liver + @@ -315214,7 +131789,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical wall that is part of an aorta, enclosing the luminal space. - http://orcid.org/0000-0002-6601-2165 + @@ -315265,10 +131840,10 @@ The modern definition of neurosecretion has evolved to include the release of an The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers. + EMAPA:35136 FMA:14283 MA:0002902 - SCTID:24996002 tunica adventitia of aorta uberon UBERON:0004664 @@ -315279,7 +131854,7 @@ The modern definition of neurosecretion has evolved to include the release of an The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0009871 @@ -315332,11 +131907,11 @@ The modern definition of neurosecretion has evolved to include the release of an membranous septum ventricle membranous septum ventricular membranous septum + EHDAA2:0004596 EMAPA:18246 FMA:7135 MA:0002939 - SCTID:278228007 VHOG:0000927 cardiac ventricular membranous septum membranous interventricular septum @@ -315360,7 +131935,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia @@ -315396,7 +131971,7 @@ The modern definition of neurosecretion has evolved to include the release of an cardiac ventricular membranous septum - http://orcid.org/0000-0002-6601-2165 + @@ -315433,7 +132008,7 @@ The modern definition of neurosecretion has evolved to include the release of an pars membranacea septi interventricularis FMA:7135 - FMA:TA + FMA:TA @@ -315500,8 +132075,8 @@ The modern definition of neurosecretion has evolved to include the release of an The muscular portion of the wall between the two lower chambers of the heart. - Wikipedia:Interventricular_septum#Portions - http://orcid.org/0000-0002-6601-2165 + + @@ -315519,7 +132094,7 @@ The modern definition of neurosecretion has evolved to include the release of an cardiac ventricular muscular septum - http://orcid.org/0000-0002-6601-2165 + @@ -315544,7 +132119,7 @@ The modern definition of neurosecretion has evolved to include the release of an pars muscularis septi interventricularis FMA:7134 - FMA:TA + FMA:TA @@ -315579,6 +132154,8 @@ The modern definition of neurosecretion has evolved to include the release of an The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane. + + BAMS:RA EMAPA:35721 FMA:84017 @@ -315588,7 +132165,6 @@ The modern definition of neurosecretion has evolved to include the release of an NLXANAT:20090205 TAO:0001429 UMLS:C0034671 - Wikipedia:Raphe_nuclei ZFA:0001429 neuronames:2495 nuclei raphes @@ -315604,7 +132180,7 @@ The modern definition of neurosecretion has evolved to include the release of an we treat NR obscurus, NR magnus etc as parts of the raphe nuclei. This is consistent with treatment in FMA, where the class is 'set of raphe nuclei' raphe nuclei - http://upload.wikimedia.org/wikipedia/commons/9/94/Gray694.png + http://upload.wikimedia.org/wikipedia/commons/9/94/Gray694.png @@ -315615,8 +132191,8 @@ The modern definition of neurosecretion has evolved to include the release of an - GO - Wikipedia + GO + Wikipedia @@ -315627,14 +132203,14 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane. + NLXANAT:20090205 - https://sourceforge.net/tracker/?func=detail&aid=3248146&group_id=36855&atid=440764 @@ -315647,7 +132223,7 @@ The modern definition of neurosecretion has evolved to include the release of an nuclei raphes FMA:84017 - FMA:TA + FMA:TA @@ -315655,6 +132231,11 @@ The modern definition of neurosecretion has evolved to include the release of an raphe nuclei FMA:84017 + + + + + raphe nuclei NLXANAT:20090205 @@ -315667,14 +132248,14 @@ The modern definition of neurosecretion has evolved to include the release of an nuclei raphes - Wikipedia:Raphe_nuclei + raphe cluster - Wikipedia:Raphe_nuclei + @@ -315715,11 +132296,11 @@ The modern definition of neurosecretion has evolved to include the release of an The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]. + + EMAPA:37496 FMA:10636 MA:0001939 - SCTID:244225009 - Wikipedia:Costocervical_trunk costocervical trunk trunk of costocervical artery uberon @@ -315727,19 +132308,19 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0004688 costo-cervical trunk - http://upload.wikimedia.org/wikipedia/commons/b/b3/Costocervical_trunk_with_branches.png + http://upload.wikimedia.org/wikipedia/commons/b/b3/Costocervical_trunk_with_branches.png The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]. - Wikipedia:Costocervical_trunk + EMAPA:37496 - MA:th + MA:th @@ -315757,7 +132338,7 @@ The modern definition of neurosecretion has evolved to include the release of an truncus costocervicalis - Wikipedia:Costocervical_trunk + @@ -315795,7 +132376,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -315838,7 +132419,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -315865,6 +132446,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of a vena cava [Automatically generated definition]. + EMAPA:37800 MA:0000713 NCIT:C49318 @@ -315877,13 +132459,13 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of a vena cava [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37800 - MA:th + MA:th @@ -315927,17 +132509,17 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of a outflow tract [Automatically generated definition]. - OBOL:automatic + OBOL:automatic It is assumed that during evolution, a circulatory system composed of the heart and endothelial tubular system first formed in vertebrates, medial smooth muscle then appeared for regulation of the system, and innervation of the muscle tissue took place. This sequence of development assumed for phylogenesis is actually realized in the ontogenetic processes.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001524 - VHOG + VHOG + DOI:10.1254/jjp.87.253 Shigei T, Tsuru H, Ishikawa N, Yoshioka K, Absence of endothelium in invertebrate blood vessels: significance of endothelium and sympathetic nerve/medial smooth muscle in the vertebrate vascular system. Japanese Journal of Pharmacology (2001) - http://bgee.unil.ch/ @@ -315964,6 +132546,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of an arterial system [Automatically generated definition]. + EMAPA:35145 MA:0000703 NCIT:C49329 @@ -315976,7 +132559,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of an arterial system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -316009,6 +132592,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of a venous system [Automatically generated definition]. + EMAPA:35907 MA:0000714 NCIT:C49320 @@ -316021,7 +132605,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of a venous system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -316071,7 +132655,7 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel endothelium that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -316079,6 +132663,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -316089,38 +132674,39 @@ The modern definition of neurosecretion has evolved to include the release of an A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches. TODO - check relationship to bulbus arteriosus A pear shaped chamber that functions as a capacitor, maintaining continuous blood flow into the gill arches. The bulbus arteriosus has three distinct layers. Hu et al. 2000.[TAO] + + + EHDAA2:0000197 EHDAA:438 EHDAA:768 EMAPA:16333 FMA:70300 NCIT:C34114 - SCTID:361525002 UMLS:C1284055 - Wikipedia:Bulbus_cordis primitive right ventricle endocardium uberon UBERON:0004706 bulbus cordis - http://upload.wikimedia.org/wikipedia/commons/c/c9/Gray466.png + http://upload.wikimedia.org/wikipedia/commons/c/c9/Gray466.png A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0010568 A pear shaped chamber that functions as a capacitor, maintaining continuous blood flow into the gill arches. The bulbus arteriosus has three distinct layers. Hu et al. 2000.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000173 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -316151,8 +132737,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -316227,7 +132813,7 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO @@ -316238,7 +132824,7 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO @@ -316249,50 +132835,50 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional An appendage that is part of an appendage girdle complex. - UBERON:cjm - https://github.com/geneontology/go-ontology/issues/9029 + + UBERON:cjm girdle-associated appendage - https://orcid.org/0000-0002-6601-2165 + limb or fin - https://orcid.org/0000-0002-6601-2165 + limb/fin - https://orcid.org/0000-0002-6601-2165 + pectoral or pelvic appendage - https://orcid.org/0000-0002-6601-2165 + pelvic/pectoral appendage - https://orcid.org/0000-0002-6601-2165 + jointed paired lateral appendage - https://orcid.org/0000-0002-6601-2165 + @@ -316366,13 +132952,13 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional - lexical + lexical @@ -316384,7 +132970,7 @@ The modern definition of neurosecretion has evolved to include the release of an hindlimb/pelvic fin - https://orcid.org/0000-0002-6601-2165 + @@ -316396,7 +132982,7 @@ The modern definition of neurosecretion has evolved to include the release of an pelvic limb/fin - https://orcid.org/0000-0002-6601-2165 + @@ -316472,13 +133058,13 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional - lexical + lexical @@ -316490,17 +133076,17 @@ The modern definition of neurosecretion has evolved to include the release of an While the skeletons of teleost pectoral fins and tetrapod forelimbs are homologous at the level of endoskeletal radials, teleosts and tetrapods do not share homologous skeletal elements at the level of 'individuated' pro-, meso-, and metapterygia. Among osteichthyans, only basal actinopterygians retain the full complement of elements present in non-osteichthyan gnathostomes.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001753 - VHOG + VHOG + DOI:10.1002/jmor.10264 Davis MC, Shubin NH, Force A, Pectoral fin and girdle development in the basal actinopterygians Polyodon spathula and Acipenser transmontanus. Journal of Morphology (2004) - http://bgee.unil.ch/ anterior limb/fin - https://orcid.org/0000-0002-6601-2165 + @@ -316518,19 +133104,19 @@ The modern definition of neurosecretion has evolved to include the release of an forelimb or pectoral fin - https://orcid.org/0000-0002-6601-2165 + forelimb/pectoral fin - https://orcid.org/0000-0002-6601-2165 + pectoral limb/fin - https://orcid.org/0000-0002-6601-2165 + @@ -316552,6 +133138,9 @@ The modern definition of neurosecretion has evolved to include the release of an The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava. + + + BTO:0001744 CALOHA:TS-0497 EMAPA:18638 @@ -316559,21 +133148,19 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002154 MESH:D007601 NCIT:C12738 - SCTID:244403000 UMLS:C0022427 - Wikipedia:Jugular_vein uberon jugular vena jugularis UBERON:0004711 jugular vein - http://upload.wikimedia.org/wikipedia/commons/f/f8/Gray558.png + http://upload.wikimedia.org/wikipedia/commons/f/f8/Gray558.png The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava. - Wikipedia:Jugular_vein + @@ -316594,6 +133181,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -316626,6 +133214,8 @@ The modern definition of neurosecretion has evolved to include the release of an The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]. EHDAA2 places this as a subtype of organism. This leads to the inference that a conceptus is an embryo (if an embryo is defined as an organism at embryo stage), which eliminates the embryonic + extra-embryonic = conceptus + + AEO:0000194 BTO:0003834 EHDAA2:0000001 @@ -316633,7 +133223,6 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:36040 NCIT:C34131 UMLS:C1516779 - Wikipedia:Conceptus embryo plus adnexa uberon UBERON:0004716 @@ -316643,8 +133232,8 @@ The modern definition of neurosecretion has evolved to include the release of an The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]. + BTO:0003834 - Wikipedia:Conceptus @@ -316659,6 +133248,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + @@ -316714,9 +133309,9 @@ The modern definition of neurosecretion has evolved to include the release of an A metameric segment of the central nervous system.[ZFA] 2009-06-18T09:00:04Z + NLX:147842 TAO:0001328 - Wikipedia:Neuromere ZFA:0001328 neural tube metameric segment neural tube segment @@ -316733,30 +133328,30 @@ The modern definition of neurosecretion has evolved to include the release of an A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres). - DOI:10.1016/j.tins.2013.06.004 - https://github.com/obophenotype/uberon/issues/318 + + A metameric segment of the central nervous system.[ZFA] - 2012-08-14 + 2012-08-14 TAO:0001328 - TAO - ZFIN:curator + TAO + ZFIN:curator neural tube metameric segment - http://orcid.org/0000-0002-6601-2165 + neuromeres TAO:0001328 - + @@ -316776,6 +133371,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -316794,8 +133390,8 @@ The modern definition of neurosecretion has evolved to include the release of an Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres. + FBbt:00005140 - http://orcid.org/0000-0002-6601-2165 @@ -316822,6 +133418,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -316841,7 +133438,7 @@ The modern definition of neurosecretion has evolved to include the release of an An organ subunit that is part of a hindbrain [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -316873,6 +133470,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -316888,6 +133486,10 @@ The modern definition of neurosecretion has evolved to include the release of an Organism at the gastrula stage. We explicitly merge the NCITA terms here UBERON:0007012 + + + + BILA:0000060 BTO:0001403 FBbt:00005317 @@ -316899,8 +133501,6 @@ The modern definition of neurosecretion has evolved to include the release of an NCIT:C34058 UMLS:C0017199 UMLS:C1284022 - Wikipedia:Gastrula - Wikipedia:Trilaminar_blastocyst gastrula embryo uberon blastocystis trilaminaris @@ -316919,8 +133519,8 @@ The modern definition of neurosecretion has evolved to include the release of an Organism at the gastrula stage. - Wikipedia:Gastrula - Wikipedia:Trilaminar_blastocyst + + @@ -316950,49 +133550,49 @@ The modern definition of neurosecretion has evolved to include the release of an blastocystis trilaminaris - https://orcid.org/0000-0002-6601-2165 + tri-laminar disc - https://orcid.org/0000-0002-6601-2165 + tri-laminar disk - https://orcid.org/0000-0002-6601-2165 + trilaminar blastocyst - https://orcid.org/0000-0002-6601-2165 + trilaminar blastoderm - https://orcid.org/0000-0002-6601-2165 + trilaminar disc - https://orcid.org/0000-0002-6601-2165 + trilaminar disk - https://orcid.org/0000-0002-6601-2165 + trilaminar germ - https://orcid.org/0000-0002-6601-2165 + @@ -317000,6 +133600,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -317021,9 +133622,9 @@ The modern definition of neurosecretion has evolved to include the release of an A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]. A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO] + EMAPA:37744 MA:0003047 - SCTID:309311006 VSAO:0000015 XAO:0004038 ZFA:0005619 @@ -317036,7 +133637,7 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO @@ -317047,36 +133648,36 @@ The modern definition of neurosecretion has evolved to include the release of an - 2012-08-14 + 2012-08-14 VSAO:0000015 - VSAO + VSAO A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]. - GO_REF:0000034 - PSPUB:0000170 + + + GO_REF:0000034 + PSPUB:0000170 VSAO:0000015 - http://dx.plos.org/10.1371/journal.pone.0051070 - https://github.com/obophenotype/uberon/issues/134 A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000015 taken from version of VSAO used in TAO and used directly in Uberon - VSAO + VSAO GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 - PSPUB:0000170 + PSPUB:0000170 EMAPA:37744 - MA:th + MA:th @@ -317101,6 +133702,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -317123,14 +133725,14 @@ The modern definition of neurosecretion has evolved to include the release of an Dermis-derived entity that is made of skeletal tissue. - http://orcid.org/0000-0002-6601-2165 - https://github.com/obophenotype/uberon/issues/206 + + dermal element - VSAO:curator + VSAO:curator @@ -317159,15 +133761,16 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that is part of an anal canal [Automatically generated definition]. + + + EMAPA:27221 EMAPA:27233 EMAPA:27543 FMA:15720 FMA:15724 NCIT:C32068 - SCTID:245448005 UMLS:C0162322 - Wikipedia:Anal_gland gland of anal canal uberon anal gland @@ -317183,8 +133786,8 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that is part of an anal canal [Automatically generated definition]. - OBOL:automatic - Wikipedia:Anal_gland + + OBOL:automatic @@ -317196,13 +133799,13 @@ The modern definition of neurosecretion has evolved to include the release of an gland of anal canal - OBOL:automatic + OBOL:automatic anal sac - Wikipedia:Anal_gland + @@ -317212,6 +133815,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -317232,14 +133836,15 @@ The modern definition of neurosecretion has evolved to include the release of an The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP]. in contrast to chondrocranium, this structure is entirely cartiliginous. In Chondricthyes this is the same as the neurocranium. FMA:76621 is an undefined fetal structure, so we assume the correct placement is here. Note that this is distinct from MA:0000317 which is the uberon:neurocranium (the part of the cranium that encloses the brain) + + + AAO:0000094 AAO:0010153 EHDAA:6031 FMA:76621 NCIT:C34121 - SCTID:155540009 UMLS:C1516496 - Wikipedia:Chondrocranium XAO:0003059 cartilaginous chondocranium cartiligionous skeletal structure of skull @@ -317255,7 +133860,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -317272,13 +133877,13 @@ The modern definition of neurosecretion has evolved to include the release of an The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP]. - Wikipedia:Chondrocranium + in contrast to chondrocranium, this structure is entirely cartiliginous. In Chondricthyes this is the same as the neurocranium. FMA:76621 is an undefined fetal structure, so we assume the correct placement is here. Note that this is distinct from MA:0000317 which is the uberon:neurocranium (the part of the cranium that encloses the brain) - FMA + FMA @@ -317290,7 +133895,7 @@ The modern definition of neurosecretion has evolved to include the release of an chondocranium - Wikipedia:Chondrocranium + @@ -317336,8 +133941,8 @@ The modern definition of neurosecretion has evolved to include the release of an Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]. note the distinction between intramembranous bone and intramembranous bone tissue. Some bones may be a mixture of both tissue types. The MA class most likely refers to a tissue type (it is under bone tissue and connective tissue; there are no child classes) + MA:0002837 - Wikipedia:Intramembranous_ossification uberon UBERON:0004764 intramembranous bone tissue @@ -317346,14 +133951,14 @@ The modern definition of neurosecretion has evolved to include the release of an Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]. + GO:0001957 - Wikipedia:Intramembranous_ossification note the distinction between intramembranous bone and intramembranous bone tissue. Some bones may be a mixture of both tissue types. The MA class most likely refers to a tissue type (it is under bone tissue and connective tissue; there are no child classes) - MA + MA @@ -317392,30 +133997,30 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. - https://orcid.org/0000-0002-6601-2165 + Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000128 - VSAO - PSPUB:0000170 + VSAO + PSPUB:0000170 Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001890 - TAO + TAO TAO:VSAO_workshop @@ -317435,7 +134040,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -317444,12 +134049,10 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a cranium. here cranium = skull - mandible - - SCTID:181792001 + cranium bone uberon UBERON:0004766 - cranial bone @@ -317517,13 +134120,13 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/The-neural-crest + Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular. - https://orcid.org/0000-0002-6601-2165 + @@ -317574,10 +134177,10 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that consists of all the joints of the body. + EMAPA:35150 FMA:23878 MA:0003007 - SCTID:361827000 VSAO:0000181 joint system set of all joints of body @@ -317596,7 +134199,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -317666,31 +134269,31 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37578 - MA:th + MA:th apparatus respiratorius submucosa - OBOL:automatic + OBOL:automatic submucosa of apparatus respiratorius - OBOL:automatic + OBOL:automatic submucosa of respiratory system - OBOL:automatic + OBOL:automatic @@ -317751,62 +134354,62 @@ The modern definition of neurosecretion has evolved to include the release of an - true - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + true + A lamina propria that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37576 - MA:th + MA:th apparatus respiratorius lamina propria - OBOL:automatic + OBOL:automatic apparatus respiratorius lamina propria mucosa - OBOL:automatic + OBOL:automatic lamina propria mucosa of apparatus respiratorius - OBOL:automatic + OBOL:automatic lamina propria mucosa of respiratory system - OBOL:automatic + OBOL:automatic lamina propria of apparatus respiratorius - OBOL:automatic + OBOL:automatic lamina propria of respiratory system - OBOL:automatic + OBOL:automatic respiratory system lamina propria mucosa - OBOL:automatic + OBOL:automatic @@ -317826,6 +134429,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -317839,6 +134443,7 @@ The modern definition of neurosecretion has evolved to include the release of an A lamina propria that is part of a gastrointestinal system. + MA:0001899 NCIT:C49299 UMLS:C1708197 @@ -317855,14 +134460,14 @@ The modern definition of neurosecretion has evolved to include the release of an - true - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + true + A lamina propria that is part of a gastrointestinal system. - OBOL:automatic + OBOL:automatic @@ -317902,6 +134507,7 @@ The modern definition of neurosecretion has evolved to include the release of an A lamina propria that is part of a gallbladder [Automatically generated definition]. + EMAPA:35371 FMA:278594 MA:0001633 @@ -317928,14 +134534,14 @@ The modern definition of neurosecretion has evolved to include the release of an - true - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + true + A lamina propria that is part of a gallbladder [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -317947,37 +134553,37 @@ The modern definition of neurosecretion has evolved to include the release of an gall bladder lamina propria - OBOL:automatic + OBOL:automatic gall bladder lamina propria mucosa - OBOL:automatic + OBOL:automatic lamina propria mucosa of gall bladder - OBOL:automatic + OBOL:automatic lamina propria mucosa of gallbladder - OBOL:automatic + OBOL:automatic lamina propria of gall bladder - OBOL:automatic + OBOL:automatic lamina propria of gallbladder - OBOL:automatic + OBOL:automatic @@ -318027,55 +134633,55 @@ The modern definition of neurosecretion has evolved to include the release of an A serous membrane that is part of a digestive system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37592 - MA:th + MA:th digestive system serosa - OBOL:automatic + OBOL:automatic digestive system serous membrane - OBOL:automatic + OBOL:automatic gastrointestinal system serous membrane - OBOL:automatic + OBOL:automatic serosa of digestive system - OBOL:automatic + OBOL:automatic serosa of gastrointestinal system - OBOL:automatic + OBOL:automatic serous membrane of digestive system - OBOL:automatic + OBOL:automatic serous membrane of gastrointestinal system - OBOL:automatic + OBOL:automatic @@ -318103,10 +134709,10 @@ The modern definition of neurosecretion has evolved to include the release of an A serous membrane that is part of a gallbladder [Automatically generated definition]. + EMAPA:35372 FMA:14659 MA:0001634 - SCTID:362197006 gall bladder serosa gall bladder serous membrane gallbladder serous membrane @@ -318126,31 +134732,31 @@ The modern definition of neurosecretion has evolved to include the release of an A serous membrane that is part of a gallbladder [Automatically generated definition]. - OBOL:automatic + OBOL:automatic gall bladder serosa - OBOL:automatic + OBOL:automatic gallbladder serous membrane - OBOL:automatic + OBOL:automatic serosa of gall bladder - OBOL:automatic + OBOL:automatic serosa of gallbladder - OBOL:automatic + OBOL:automatic @@ -318162,13 +134768,13 @@ The modern definition of neurosecretion has evolved to include the release of an serous membrane of gall bladder - OBOL:automatic + OBOL:automatic serous membrane of gallbladder - OBOL:automatic + OBOL:automatic @@ -318181,7 +134787,7 @@ The modern definition of neurosecretion has evolved to include the release of an tunica serosa vesicae biliaris FMA:14659 - FMA:TA + FMA:TA @@ -318244,73 +134850,73 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical wall that is part of a cardiac ventricle [Automatically generated definition]. - OBOL:automatic + OBOL:automatic anatomical wall of cardiac ventricle - OBOL:automatic + OBOL:automatic anatomical wall of heart ventricle - OBOL:automatic + OBOL:automatic anatomical wall of lower chamber of heart - OBOL:automatic + OBOL:automatic anatomical wall of ventricle of heart - OBOL:automatic + OBOL:automatic cardiac ventricle anatomical wall - OBOL:automatic + OBOL:automatic cardiac ventricle wall - OBOL:automatic + OBOL:automatic heart ventricle anatomical wall - OBOL:automatic + OBOL:automatic lower chamber of heart anatomical wall - OBOL:automatic + OBOL:automatic lower chamber of heart wall - OBOL:automatic + OBOL:automatic ventricle of heart anatomical wall - OBOL:automatic + OBOL:automatic ventricle of heart wall - OBOL:automatic + OBOL:automatic @@ -318322,25 +134928,25 @@ The modern definition of neurosecretion has evolved to include the release of an wall of cardiac ventricle - OBOL:automatic + OBOL:automatic wall of heart ventricle - OBOL:automatic + OBOL:automatic wall of lower chamber of heart - OBOL:automatic + OBOL:automatic wall of ventricle of heart - OBOL:automatic + OBOL:automatic @@ -318405,80 +135011,80 @@ The modern definition of neurosecretion has evolved to include the release of an The mucous membrane lining the respiratory tract. MESH:A04.760 - MGI:cwg + MGI:cwg MP:0002277 EMAPA:37577 - MA:th + MA:th apparatus respiratorius mucosa - OBOL:automatic + OBOL:automatic apparatus respiratorius mucosa of organ - OBOL:automatic + OBOL:automatic apparatus respiratorius mucous membrane - OBOL:automatic + OBOL:automatic mucosa of apparatus respiratorius - OBOL:automatic + OBOL:automatic mucosa of organ of apparatus respiratorius - OBOL:automatic + OBOL:automatic mucosa of organ of respiratory system - OBOL:automatic + OBOL:automatic mucosa of respiratory system - OBOL:automatic + OBOL:automatic mucous membrane of apparatus respiratorius - OBOL:automatic + OBOL:automatic mucous membrane of respiratory system - OBOL:automatic + OBOL:automatic respiratory system mucosa of organ - OBOL:automatic + OBOL:automatic respiratory system mucous membrane - OBOL:automatic + OBOL:automatic @@ -318510,6 +135116,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -318547,11 +135154,11 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a gastrointestinal system. + BTO:0000546 BTO:0005568 EMAPA:36591 MA:0001521 - SCTID:410433007 digestive tract mucosa gut mucosa gut mucuous membrane @@ -318570,7 +135177,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:16417468 + @@ -318581,7 +135188,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:16417468 + @@ -318592,7 +135199,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:16417468 + @@ -318609,13 +135216,13 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a gastrointestinal system. - OBOL:automatic + OBOL:automatic digestive tract mucosa - https://orcid.org/0000-0002-6601-2165 + @@ -318627,13 +135234,13 @@ The modern definition of neurosecretion has evolved to include the release of an gut mucuous membrane - https://orcid.org/0000-0002-6601-2165 + mucosa of gut - https://orcid.org/0000-0002-6601-2165 + @@ -318690,31 +135297,31 @@ The modern definition of neurosecretion has evolved to include the release of an A mucous gland that is part of the skin. - http://orcid.org/0000-0002-6601-2165 + mucous gland of entire skin - OBOL:automatic + OBOL:automatic mucous gland of skin of body - OBOL:automatic + OBOL:automatic skin mucus gland - OBOL:automatic + OBOL:automatic skin of body mucous gland - OBOL:automatic + OBOL:automatic @@ -318733,6 +135340,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -318741,6 +135349,7 @@ The modern definition of neurosecretion has evolved to include the release of an A secretion that is part of a endocrine pancreas [Automatically generated definition]. + MA:0002517 NCIT:C33255 UMLS:C1518866 @@ -318756,7 +135365,7 @@ The modern definition of neurosecretion has evolved to include the release of an A secretion that is part of a endocrine pancreas [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -318768,7 +135377,7 @@ The modern definition of neurosecretion has evolved to include the release of an endocrine pancreas secretion - OBOL:automatic + OBOL:automatic @@ -318780,13 +135389,13 @@ The modern definition of neurosecretion has evolved to include the release of an pars endocrina pancreatis secretion - OBOL:automatic + OBOL:automatic secretion of pars endocrina pancreatis - OBOL:automatic + OBOL:automatic @@ -318805,6 +135414,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -318813,6 +135423,7 @@ The modern definition of neurosecretion has evolved to include the release of an A secretion that is part of a exocrine pancreas [Automatically generated definition]. + MA:0002518 NCIT:C33256 UMLS:C1518867 @@ -318828,7 +135439,7 @@ The modern definition of neurosecretion has evolved to include the release of an A secretion that is part of a exocrine pancreas [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -318840,7 +135451,7 @@ The modern definition of neurosecretion has evolved to include the release of an exocrine pancreas secretion - OBOL:automatic + OBOL:automatic @@ -318852,13 +135463,13 @@ The modern definition of neurosecretion has evolved to include the release of an pars exocrina pancreatis secretion - OBOL:automatic + OBOL:automatic secretion of pars exocrina pancreatis - OBOL:automatic + OBOL:automatic @@ -318878,6 +135489,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -318885,6 +135497,7 @@ The modern definition of neurosecretion has evolved to include the release of an A secretion that is part of a esophagus [Automatically generated definition]. + FMA:79662 MA:0002514 NCIT:C52555 @@ -318903,7 +135516,7 @@ The modern definition of neurosecretion has evolved to include the release of an A secretion that is part of a esophagus [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -318921,31 +135534,31 @@ The modern definition of neurosecretion has evolved to include the release of an gullet secretion - OBOL:automatic + OBOL:automatic oesophagus secretion - OBOL:automatic + OBOL:automatic secretion of esophagus - OBOL:automatic + OBOL:automatic secretion of gullet - OBOL:automatic + OBOL:automatic secretion of oesophagus - OBOL:automatic + OBOL:automatic @@ -318972,6 +135585,7 @@ The modern definition of neurosecretion has evolved to include the release of an A secretion that is part of a pancreas [Automatically generated definition]. + MA:0002516 NCIT:C13270 UMLS:C0030296 @@ -318985,7 +135599,7 @@ The modern definition of neurosecretion has evolved to include the release of an A secretion that is part of a pancreas [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -318997,13 +135611,13 @@ The modern definition of neurosecretion has evolved to include the release of an pancreatic secretion - OBOL:automatic + OBOL:automatic secretion of pancreas - OBOL:automatic + OBOL:automatic @@ -319042,13 +135656,13 @@ The modern definition of neurosecretion has evolved to include the release of an uberon UBERON:0004797 blood vessel layer - https://upload.wikimedia.org/wikipedia/commons/6/61/Blood_vessels.svg + https://upload.wikimedia.org/wikipedia/commons/6/61/Blood_vessels.svg Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia. - http://orcid.org/0000-0002-6601-2165 + @@ -319089,11 +135703,11 @@ The modern definition of neurosecretion has evolved to include the release of an The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi. + BTO:0000419 CALOHA:TS-0023 EMAPA:32827 MA:0001480 - SCTID:321764001 VHOG:0000981 epithelial tissue of respiratory tract epithelium of respiratory tract @@ -319109,27 +135723,27 @@ The modern definition of neurosecretion has evolved to include the release of an The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi. - ISBN:0-683-40008-8 - MGI:anna + ISBN:0-683-40008-8 + MGI:anna MP:0010942 epithelial tissue of respiratory tract - OBOL:automatic + OBOL:automatic epithelium of respiratory tract - OBOL:automatic + OBOL:automatic respiratory tract epithelial tissue - OBOL:automatic + OBOL:automatic @@ -319188,49 +135802,49 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic apparatus respiratorius epithelial tissue - OBOL:automatic + OBOL:automatic apparatus respiratorius epithelium - OBOL:automatic + OBOL:automatic epithelial tissue of apparatus respiratorius - OBOL:automatic + OBOL:automatic epithelial tissue of respiratory system - OBOL:automatic + OBOL:automatic epithelium of apparatus respiratorius - OBOL:automatic + OBOL:automatic epithelium of respiratory system - OBOL:automatic + OBOL:automatic respiratory system epithelial tissue - OBOL:automatic + OBOL:automatic @@ -319274,49 +135888,49 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a digestive system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic digestive system epithelial tissue - OBOL:automatic + OBOL:automatic digestive system epithelium - OBOL:automatic + OBOL:automatic epithelial tissue of digestive system - OBOL:automatic + OBOL:automatic epithelial tissue of gastrointestinal system - OBOL:automatic + OBOL:automatic epithelium of digestive system - OBOL:automatic + OBOL:automatic epithelium of gastrointestinal system - OBOL:automatic + OBOL:automatic gastrointestinal system epithelial tissue - OBOL:automatic + OBOL:automatic @@ -319356,31 +135970,31 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a lower respiratory tract [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37549 - MA:th + MA:th epithelial tissue of lower respiratory tract - OBOL:automatic + OBOL:automatic epithelium of lower respiratory tract - OBOL:automatic + OBOL:automatic lower respiratory tract epithelial tissue - OBOL:automatic + OBOL:automatic @@ -319416,6 +136030,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any epithelium that lines one of the bile ducts. The irregularly shaped proliferating bile ducts are lined by normal cuboidal epithelium. + BTO:0000417 MA:0001629 NCIT:C43616 @@ -319432,7 +136047,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any epithelium that lines one of the bile ducts. - http://orcid.org/0000-0002-6601-2165 + @@ -319450,19 +136065,19 @@ The modern definition of neurosecretion has evolved to include the release of an biliary duct epithelium - OBOL:automatic + OBOL:automatic epithelium of bile duct - OBOL:automatic + OBOL:automatic epithelium of biliary duct - OBOL:automatic + OBOL:automatic @@ -319489,6 +136104,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a extrahepatic bile duct [Automatically generated definition]. + EHDAA2:0000742 EHDAA:3051 MA:0002661 @@ -319505,7 +136121,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a extrahepatic bile duct [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -319517,19 +136133,19 @@ The modern definition of neurosecretion has evolved to include the release of an epithelial tissue of extrahepatic bile duct - OBOL:automatic + OBOL:automatic epithelium of extrahepatic bile duct - OBOL:automatic + OBOL:automatic extrahepatic bile duct epithelial tissue - OBOL:automatic + OBOL:automatic @@ -319556,6 +136172,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a intrahepatic bile duct [Automatically generated definition]. + EHDAA2:0000743 EHDAA:3053 MA:0002662 @@ -319572,7 +136189,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a intrahepatic bile duct [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -319584,19 +136201,19 @@ The modern definition of neurosecretion has evolved to include the release of an epithelial tissue of intrahepatic bile duct - OBOL:automatic + OBOL:automatic epithelium of intrahepatic bile duct - OBOL:automatic + OBOL:automatic intrahepatic bile duct epithelial tissue - OBOL:automatic + OBOL:automatic @@ -319638,43 +136255,43 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37583 - MA:th + MA:th respiratory system skeletal muscle tissue - OBOL:automatic + OBOL:automatic skeletal muscle of apparatus respiratorius - OBOL:automatic + OBOL:automatic skeletal muscle of respiratory system - OBOL:automatic + OBOL:automatic skeletal muscle tissue of apparatus respiratorius - OBOL:automatic + OBOL:automatic skeletal muscle tissue of respiratory system - OBOL:automatic + OBOL:automatic @@ -319720,19 +136337,19 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition]. - OBOL:automatic + OBOL:automatic esophagus skeletal muscle tissue - OBOL:automatic + OBOL:automatic skeletal muscle of esophagus - OBOL:automatic + OBOL:automatic @@ -319780,79 +136397,79 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37393 - MA:th + MA:th anal part of perineum skeletal muscle - OBOL:automatic + OBOL:automatic anal part of perineum skeletal muscle tissue - OBOL:automatic + OBOL:automatic anal region skeletal muscle tissue - OBOL:automatic + OBOL:automatic anal triangle skeletal muscle - OBOL:automatic + OBOL:automatic anal triangle skeletal muscle tissue - OBOL:automatic + OBOL:automatic skeletal muscle of anal part of perineum - OBOL:automatic + OBOL:automatic skeletal muscle of anal region - OBOL:automatic + OBOL:automatic skeletal muscle of anal triangle - OBOL:automatic + OBOL:automatic skeletal muscle tissue of anal part of perineum - OBOL:automatic + OBOL:automatic skeletal muscle tissue of anal region - OBOL:automatic + OBOL:automatic skeletal muscle tissue of anal triangle - OBOL:automatic + OBOL:automatic @@ -319893,31 +136510,31 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37642 - MA:th + MA:th lip skeletal muscle tissue - OBOL:automatic + OBOL:automatic skeletal muscle of lip - OBOL:automatic + OBOL:automatic skeletal muscle tissue of lip - OBOL:automatic + OBOL:automatic @@ -319955,13 +136572,13 @@ The modern definition of neurosecretion has evolved to include the release of an Smooth muscle tissue in all or part of a hepatic duct. - http://orcid.org/0000-0002-6601-2165 + EMAPA:37598 - MA:th + MA:th @@ -320035,8 +136652,8 @@ The modern definition of neurosecretion has evolved to include the release of an - true - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + true + @@ -320047,85 +136664,85 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + An endothelium of artery that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37566 - MA:th + MA:th apparatus respiratorius arterial endothelium - OBOL:automatic + OBOL:automatic apparatus respiratorius artery endothelium - OBOL:automatic + OBOL:automatic apparatus respiratorius endothelium of artery - OBOL:automatic + OBOL:automatic arterial endothelium of apparatus respiratorius - OBOL:automatic + OBOL:automatic arterial endothelium of respiratory system - OBOL:automatic + OBOL:automatic artery endothelium of apparatus respiratorius - OBOL:automatic + OBOL:automatic artery endothelium of respiratory system - OBOL:automatic + OBOL:automatic endothelium of artery of apparatus respiratorius - OBOL:automatic + OBOL:automatic endothelium of artery of respiratory system - OBOL:automatic + OBOL:automatic respiratory system artery endothelium - OBOL:automatic + OBOL:automatic respiratory system endothelium of artery - OBOL:automatic + OBOL:automatic @@ -320193,85 +136810,85 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + An endothelium of vein that is part of a respiratory system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37585 - MA:th + MA:th apparatus respiratorius endothelium of vein - OBOL:automatic + OBOL:automatic apparatus respiratorius vein endothelium - OBOL:automatic + OBOL:automatic apparatus respiratorius venous endothelium - OBOL:automatic + OBOL:automatic endothelium of vein of apparatus respiratorius - OBOL:automatic + OBOL:automatic endothelium of vein of respiratory system - OBOL:automatic + OBOL:automatic respiratory system endothelium of vein - OBOL:automatic + OBOL:automatic respiratory system vein endothelium - OBOL:automatic + OBOL:automatic vein endothelium of apparatus respiratorius - OBOL:automatic + OBOL:automatic vein endothelium of respiratory system - OBOL:automatic + OBOL:automatic venous endothelium of apparatus respiratorius - OBOL:automatic + OBOL:automatic venous endothelium of respiratory system - OBOL:automatic + OBOL:automatic @@ -320299,6 +136916,7 @@ The modern definition of neurosecretion has evolved to include the release of an The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall. + BTO:0000394 CALOHA:TS-0047 EFO:0002597 @@ -320324,7 +136942,7 @@ The modern definition of neurosecretion has evolved to include the release of an The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall. - MGI:csmith + MGI:csmith MP:0009864 @@ -320337,43 +136955,43 @@ The modern definition of neurosecretion has evolved to include the release of an adult aorta endothelium - OBOL:automatic + OBOL:automatic endothelium of adult aorta - OBOL:automatic + OBOL:automatic endothelium of aorta - OBOL:automatic + OBOL:automatic endothelium of trunk of aortic tree - OBOL:automatic + OBOL:automatic endothelium of trunk of systemic arterial tree - OBOL:automatic + OBOL:automatic trunk of aortic tree endothelium - OBOL:automatic + OBOL:automatic trunk of systemic arterial tree endothelium - OBOL:automatic + OBOL:automatic @@ -320408,6 +137026,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of the cardiovascular system. consider merging with 'endothelium' Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG] + BTO:0001853 EMAPA:35201 GAID:519 @@ -320430,17 +137049,17 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of the cardiovascular system. - https://orcid.org/0000-0002-6601-2165 + Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001217 - VHOG + VHOG + ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.207 - http://bgee.unil.ch/ @@ -320453,14 +137072,14 @@ The modern definition of neurosecretion has evolved to include the release of an endothelia ZFA:0001639 - + vascular endothelia XAO:0000356 - + @@ -320502,31 +137121,31 @@ The modern definition of neurosecretion has evolved to include the release of an A mesentery that is part of a digestive system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37068 - MA:th + MA:th digestive system mesentery - OBOL:automatic + OBOL:automatic mesentery of digestive system - OBOL:automatic + OBOL:automatic mesentery of gastrointestinal system - OBOL:automatic + OBOL:automatic @@ -320576,79 +137195,79 @@ The modern definition of neurosecretion has evolved to include the release of an A connective tissue that surrounds a skeletal muscle tissue. - OBOL:automatic + OBOL:automatic EMAPA:37743 - MA:th + MA:th connective tissue of skeletal muscle - OBOL:automatic + OBOL:automatic connective tissue of skeletal muscle tissue - OBOL:automatic + OBOL:automatic portion of connective tissue of skeletal muscle - OBOL:automatic + OBOL:automatic portion of connective tissue of skeletal muscle tissue - OBOL:automatic + OBOL:automatic skeletal muscle portion of connective tissue - OBOL:automatic + OBOL:automatic skeletal muscle textus connectivus - OBOL:automatic + OBOL:automatic skeletal muscle tissue connective tissue - OBOL:automatic + OBOL:automatic skeletal muscle tissue portion of connective tissue - OBOL:automatic + OBOL:automatic skeletal muscle tissue textus connectivus - OBOL:automatic + OBOL:automatic textus connectivus of skeletal muscle - OBOL:automatic + OBOL:automatic textus connectivus of skeletal muscle tissue - OBOL:automatic + OBOL:automatic @@ -320701,19 +137320,19 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid. - http://orcid.org/0000-0002-6601-2165 + eye-associated gland - http://orcid.org/0000-0002-6601-2165 + gland of eye - OBOL:automatic + OBOL:automatic @@ -320780,14 +137399,14 @@ The modern definition of neurosecretion has evolved to include the release of an A vasculature that is part of a retina [Automatically generated definition]. - OBOL:automatic + OBOL:automatic - PMID:21622558 - PMID:2772405 + + michaelerice @@ -320818,13 +137437,13 @@ The modern definition of neurosecretion has evolved to include the release of an retinal vasculature - OBOL:automatic + OBOL:automatic set of blood vessels of retina - OBOL:automatic + OBOL:automatic @@ -320837,7 +137456,7 @@ The modern definition of neurosecretion has evolved to include the release of an vasa sanguinea retinae FMA:76552 - FMA:TA + FMA:TA @@ -320857,6 +137476,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -320872,10 +137492,10 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye. note that the AAO and ZFA class is a cavity + + AAO:0000343 FMA:84961 - SCTID:280541000 - Wikipedia:Orbit_(anatomy) ZFA:0005558 uberon orbit @@ -320886,14 +137506,14 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye. - http://orcid.org/0000-0002-6601-2165 + note that the AAO and ZFA class is a cavity - AAO - https://github.com/obophenotype/uberon/issues/462 + AAO + https://github.com/obophenotype/uberon/issues/462 @@ -320907,6 +137527,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -320923,10 +137544,10 @@ The modern definition of neurosecretion has evolved to include the release of an Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]. We group the BILA class here. Considering adding more general class for metazoa grouping cardiogenic successors visceral mesoderm + AAO:0011102 BILA:0000044 FMA:295568 - Wikipedia:Lateral_plate_mesoderm#Division_into_layers XAO:0000276 inner layer of lateral plate mesoderm uberon @@ -320939,7 +137560,7 @@ The modern definition of neurosecretion has evolved to include the release of an Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]. - Wikipedia:Lateral_plate_mesoderm#Division_into_layers + @@ -320951,9 +137572,9 @@ The modern definition of neurosecretion has evolved to include the release of an visceral mesoderm + + BILA:0000044 - http://www.drugs.com/dict/visceral-mesoderm.html - http://www.stedmans.com/ @@ -320967,6 +137588,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -320988,6 +137610,8 @@ The modern definition of neurosecretion has evolved to include the release of an A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP]. TODO - check relationship to LPM + + EHDAA2:0001903 EHDAA:383 EMAPA:16181 @@ -320995,12 +137619,11 @@ The modern definition of neurosecretion has evolved to include the release of an NCIT:C34303 UMLS:C1519472 VHOG:0000558 - Wikipedia:Splanchnopleure uberon ventral splanchnic mesoderm UBERON:0004873 splanchnopleure - http://upload.wikimedia.org/wikipedia/commons/2/28/Gray16.png + http://upload.wikimedia.org/wikipedia/commons/2/28/Gray16.png @@ -321011,13 +137634,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP]. - Wikipedia:Splanchnopleure + @@ -321029,7 +137652,7 @@ The modern definition of neurosecretion has evolved to include the release of an ventral splanchnic mesoderm - Wikipedia:Intraembryonic_coelom + @@ -321037,6 +137660,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -321059,6 +137683,8 @@ The modern definition of neurosecretion has evolved to include the release of an A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP]. Gives rise to the paired appendages in jawed vertebrates. a persistent somatopleure through the redistribution and expansion of the lateral plate mesoderm is a synapomorphy for gnathostomes and a critical step in generating a novel developmental module with dramatic evolutionary potentia (Tulenko et al. 2012) http://burkelab.research.wesleyan.edu/current-projects/lamprey/ sources differ as to whether this is part-of or develops-from the LPM + + EHDAA2:0001847 EHDAA:381 EMAPA:16180 @@ -321066,11 +137692,10 @@ The modern definition of neurosecretion has evolved to include the release of an NCIT:C34301 UMLS:C1519423 VHOG:0000557 - Wikipedia:Somatopleure uberon UBERON:0004874 somatopleure - http://upload.wikimedia.org/wikipedia/commons/2/28/Gray16.png + http://upload.wikimedia.org/wikipedia/commons/2/28/Gray16.png @@ -321081,13 +137706,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP]. - Wikipedia:Somatopleure + @@ -321101,6 +137726,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -321141,7 +137767,7 @@ The modern definition of neurosecretion has evolved to include the release of an The central region of trunk mesoderm. This tissue forms the notochord. - https://orcid.org/0000-0002-6601-2165 + @@ -321159,7 +137785,7 @@ The modern definition of neurosecretion has evolved to include the release of an dorsal mesoderm - https://github.com/obophenotype/uberon/wiki/The-neural-crest + @@ -321226,7 +137852,7 @@ The modern definition of neurosecretion has evolved to include the release of an mesenchyme of lung - OBOL:automatic + OBOL:automatic @@ -321281,7 +137907,6 @@ The modern definition of neurosecretion has evolved to include the release of an A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila. - optic nerve BTO:0000966 EV:0100351 @@ -321291,7 +137916,6 @@ The modern definition of neurosecretion has evolved to include the release of an uberon UBERON:0004904 - for the vertebrate-specific structure, see UBERON:0000941 (cranial nerve II) neuron projection bundle connecting eye with brain @@ -321300,7 +137924,7 @@ The modern definition of neurosecretion has evolved to include the release of an A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila. - http://orcid.org/0000-0002-6601-2165 + @@ -321321,7 +137945,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts. + Anatomical cluster that connects two or more adjacent skeletal elements or hardened body parts. FBbt:00005811 joint uberon @@ -321332,8 +137956,8 @@ The modern definition of neurosecretion has evolved to include the release of an - Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts. - http://orcid.org/0000-0002-6601-2165 + Anatomical cluster that connects two or more adjacent skeletal elements or hardened body parts. + @@ -321412,11 +138036,12 @@ The modern definition of neurosecretion has evolved to include the release of an MA class was moved from here. See https://github.com/obophenotype/uberon/issues/509 WP: small intestine, large intestine, anus. Anal canal not part of LGIT according to FMA, but anus is considered part of LGIT according to WP. Duodenum overlaps both U/L gut + + + FMA:49179 NCIT:C33010 - SCTID:279973004 UMLS:C0226875 - Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract galen:LowerGastrointestinalTract lower GI tract lower gastrointestinal tract @@ -321429,19 +138054,19 @@ The modern definition of neurosecretion has evolved to include the release of an The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition]. - Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract + MA class was moved from here. See https://github.com/obophenotype/uberon/issues/509 - MA + MA WP: small intestine, large intestine, anus. Anal canal not part of LGIT according to FMA, but anus is considered part of LGIT according to WP. Duodenum overlaps both U/L - FMA + FMA @@ -321470,11 +138095,12 @@ The modern definition of neurosecretion has evolved to include the release of an The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum. WP: small intestine, large intestine, anus. Anal canal not part of LGIT according to FMA, but anus is considered part of LGIT according to WP. Duodenum overlaps both U/L. In Galen, entire GI tract excludes esophagus + + + FMA:49177 NCIT:C33837 - SCTID:181244000 UMLS:C0226874 - Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract galen:UpperGastrointestinalTract upper GI tract upper gastrointestinal tract @@ -321487,13 +138113,13 @@ The modern definition of neurosecretion has evolved to include the release of an The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum. - Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract + WP: small intestine, large intestine, anus. Anal canal not part of LGIT according to FMA, but anus is considered part of LGIT according to WP. Duodenum overlaps both U/L. In Galen, entire GI tract excludes esophagus - FMA + FMA @@ -321519,6 +138145,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -321528,6 +138155,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium surrounding a gonad. after reasoning this should subsume the more specific germinal epithelium classes. We include the fly structure here although it is not clear if the sheath is an epithelium or a multi-tissue structure that includes epithelium as parts + EHDAA:4032 EHDAA:5931 NCIT:C32676 @@ -321543,7 +138171,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium surrounding a gonad. - OBOL:automatic + OBOL:automatic @@ -321555,13 +138183,13 @@ The modern definition of neurosecretion has evolved to include the release of an gonad epithelium - OBOL:automatic + OBOL:automatic gonadal epithelium - OBOL:automatic + OBOL:automatic @@ -321607,19 +138235,19 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium surrounding an ovary. - OBOL:automatic + OBOL:automatic ovarian epithelium - OBOL:automatic + OBOL:automatic ovary epithelium - OBOL:automatic + OBOL:automatic @@ -321664,13 +138292,13 @@ The modern definition of neurosecretion has evolved to include the release of an hepatic diverticulum UBERON:0004912 biliary bud - http://upload.wikimedia.org/wikipedia/commons/4/4f/Gray1088.png + http://upload.wikimedia.org/wikipedia/commons/4/4f/Gray1088.png - EHDAA2 + EHDAA2 @@ -321681,7 +138309,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -321692,7 +138320,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EMAPA + EMAPA @@ -321748,15 +138376,16 @@ The modern definition of neurosecretion has evolved to include the release of an A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct. Ampulla formed by the union of the pancreatic duct and the common bile duct where they enter the intestine.[TAO] + + + CALOHA:TS-2348 FMA:15076 GAID:283 MESH:D014670 NCIT:C13011 - SCTID:362200007 TAO:0005167 UMLS:C0042425 - Wikipedia:Ampulla_of_Vater ZFA:0005167 galen:AmpullaOfVater Vater's ampulla @@ -321773,21 +138402,21 @@ The modern definition of neurosecretion has evolved to include the release of an hepatopancreatic ampulla - http://upload.wikimedia.org/wikipedia/commons/1/1e/Biliary_system_new.svg + http://upload.wikimedia.org/wikipedia/commons/1/1e/Biliary_system_new.svg A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct. - Wikipedia:Ampulla_of_Vater + Ampulla formed by the union of the pancreatic duct and the common bile duct where they enter the intestine.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005167 - TAO + TAO ZFIN:ZDB-PUB-070212-11 ZFIN:ZDB-PUB-080414-12 @@ -321802,7 +138431,7 @@ The modern definition of neurosecretion has evolved to include the release of an ampulla biliaropancreatica FMA:15076 - FMA:TA + FMA:TA @@ -321821,14 +138450,14 @@ The modern definition of neurosecretion has evolved to include the release of an ampulla Vaterii - Wikipedia:Ampulla_of_Vater + ampulla hepatopancreatica - Wikipedia:Ampulla_of_Vater + @@ -321843,6 +138472,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -321851,31 +138481,30 @@ The modern definition of neurosecretion has evolved to include the release of an One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct. + EMAPA:18662 FMA:15953 MA:0003107 NCIT:C119578 - SCTID:245389007 papilla duodenalis papilla of duodenum uberon papilla duodeni UBERON:0004914 duodenal papilla - http://upload.wikimedia.org/wikipedia/commons/4/43/Gray1057.png - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Small_Intestine.glb + http://upload.wikimedia.org/wikipedia/commons/4/43/Gray1057.png One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct. - http://medical-dictionary.thefreedictionary.com/duodenal+papilla + papilla duodeni - Wikipedia:Major_duodenal_papilla + @@ -321905,14 +138534,15 @@ The modern definition of neurosecretion has evolved to include the release of an Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP]. + + + EMAPA:18663 FMA:15077 GAID:285 MESH:D009803 NCIT:C13065 - SCTID:181271000 UMLS:C0028872 - Wikipedia:Sphincter_of_ampulla Oddi's sphincter hepatopancreatic ampullary sphincter musculus sphincter ampullae @@ -321923,13 +138553,13 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0004915 sphincter of hepatopancreatic ampulla - http://upload.wikimedia.org/wikipedia/commons/4/43/Gray1057.png + http://upload.wikimedia.org/wikipedia/commons/4/43/Gray1057.png Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP]. - Wikipedia:Sphincter_of_ampulla + @@ -321954,7 +138584,7 @@ The modern definition of neurosecretion has evolved to include the release of an musculus sphincter ampullae hepatopancreatica FMA:15077 - FMA:TA + FMA:TA @@ -322005,7 +138635,7 @@ The modern definition of neurosecretion has evolved to include the release of an A sphincter muscle that is part of a anal region. - OBOL:automatic + OBOL:automatic @@ -322024,6 +138654,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -322039,17 +138670,14 @@ The modern definition of neurosecretion has evolved to include the release of an A proximal-distal subdivision of the digestive tract. intended to denote both embryonic and adult structures. Note the FMA grouping here is not quite correct. - FBbt:00100315 FMA:71131 uberon alimentary system subdivision - gut section intestinal tract segment of intestinal tract subdivision of alimentary system UBERON:0004921 - subdivision of digestive tract @@ -322057,7 +138685,7 @@ The modern definition of neurosecretion has evolved to include the release of an A proximal-distal subdivision of the digestive tract. - http://orcid.org/0000-0002-6601-2165 + @@ -322065,12 +138693,6 @@ The modern definition of neurosecretion has evolved to include the release of an alimentary system subdivision FMA:71131 - - - - gut section - FBbt:00100315 - @@ -322107,7 +138729,7 @@ The modern definition of neurosecretion has evolved to include the release of an A part of a wall of an organ that forms a layer. - http://orcid.org/0000-0002-6601-2165 + @@ -322135,9 +138757,9 @@ The modern definition of neurosecretion has evolved to include the release of an The tissue underlying the tunica mucosa of the pharynx. + BTO:0002113 FMA:75144 - SCTID:19594009 pharyngeal submucosa pharynx submucosa tela submucosa pharyngea @@ -322165,14 +138787,14 @@ The modern definition of neurosecretion has evolved to include the release of an pharynx submucosa - OBOL:automatic + OBOL:automatic tela submucosa pharyngea FMA:75144 - FMA:TA + FMA:TA @@ -322230,13 +138852,13 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a cystic duct [Automatically generated definition]. - OBOL:automatic + OBOL:automatic cystic duct submucosa - OBOL:automatic + OBOL:automatic @@ -322279,13 +138901,13 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a sigmoid colon [Automatically generated definition]. - OBOL:automatic + OBOL:automatic sigmoid colon submucosa - OBOL:automatic + OBOL:automatic @@ -322328,49 +138950,49 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a body of stomach [Automatically generated definition]. - OBOL:automatic + OBOL:automatic body of stomach submucosa - OBOL:automatic + OBOL:automatic corpus gastricum (ventriculare) submucosa - OBOL:automatic + OBOL:automatic gastric body submucosa - OBOL:automatic + OBOL:automatic stomach body submucosa - OBOL:automatic + OBOL:automatic submucosa of corpus gastricum (ventriculare) - OBOL:automatic + OBOL:automatic submucosa of gastric body - OBOL:automatic + OBOL:automatic submucosa of stomach body - OBOL:automatic + OBOL:automatic @@ -322411,37 +139033,37 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a pyloric antrum [Automatically generated definition]. - OBOL:automatic + OBOL:automatic antrum of stomach submucosa - OBOL:automatic + OBOL:automatic pyloric antrum submucosa - OBOL:automatic + OBOL:automatic stomach pyloric antrum submucosa - OBOL:automatic + OBOL:automatic submucosa of antrum of stomach - OBOL:automatic + OBOL:automatic submucosa of stomach pyloric antrum - OBOL:automatic + OBOL:automatic @@ -322484,38 +139106,43 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a pylorus [Automatically generated definition]. - OBOL:automatic + OBOL:automatic pyloric part of stomach submucosa - OBOL:automatic + OBOL:automatic pylorus submucosa FMA:17462 - OBOL:automatic + + + + + pylorus submucosa + OBOL:automatic stomach pyloric region submucosa - OBOL:automatic + OBOL:automatic submucosa of pyloric part of stomach - OBOL:automatic + OBOL:automatic submucosa of stomach pyloric region - OBOL:automatic + OBOL:automatic @@ -322555,25 +139182,25 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a biliary tree [Automatically generated definition]. - OBOL:automatic + OBOL:automatic biliary tract submucosa - OBOL:automatic + OBOL:automatic biliary tree submucosa - OBOL:automatic + OBOL:automatic submucosa of biliary tract - OBOL:automatic + OBOL:automatic @@ -322613,13 +139240,13 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a common bile duct [Automatically generated definition]. - OBOL:automatic + OBOL:automatic common bile duct submucosa - OBOL:automatic + OBOL:automatic @@ -322631,13 +139258,13 @@ The modern definition of neurosecretion has evolved to include the release of an ductus choledochus (biliaris) submucosa - OBOL:automatic + OBOL:automatic submucosa of ductus choledochus (biliaris) - OBOL:automatic + OBOL:automatic @@ -322677,13 +139304,13 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a common hepatic duct [Automatically generated definition]. - OBOL:automatic + OBOL:automatic common hepatic duct submucosa - OBOL:automatic + OBOL:automatic @@ -322695,13 +139322,13 @@ The modern definition of neurosecretion has evolved to include the release of an hepatic duct submucosa - OBOL:automatic + OBOL:automatic submucosa of hepatic duct - OBOL:automatic + OBOL:automatic @@ -322739,13 +139366,13 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a right hepatic duct [Automatically generated definition]. - OBOL:automatic + OBOL:automatic right hepatic duct submucosa - OBOL:automatic + OBOL:automatic @@ -322789,13 +139416,13 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a left hepatic duct [Automatically generated definition]. - OBOL:automatic + OBOL:automatic left hepatic duct submucosa - OBOL:automatic + OBOL:automatic @@ -322806,6 +139433,63 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a bronchiole [Automatically generated definition]. + FMA:62775 + bronchiole submucosa + lobular bronchiole submucosa + submucosa of lobular bronchiole + uberon + UBERON:0004952 + submucosa of bronchiole + + + + + A submucosa that is part of a bronchiole [Automatically generated definition]. + OBOL:automatic + + + + + bronchiole submucosa + OBOL:automatic + + + + + lobular bronchiole submucosa + OBOL:automatic + + + + + submucosa of lobular bronchiole + OBOL:automatic + + + + @@ -322845,31 +139529,31 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a cystic duct [Automatically generated definition]. - OBOL:automatic + OBOL:automatic cystic duct mucosa - OBOL:automatic + OBOL:automatic cystic duct mucosa of organ - OBOL:automatic + OBOL:automatic cystic duct mucous membrane - OBOL:automatic + OBOL:automatic cystic duct organ mucosa - OBOL:automatic + OBOL:automatic @@ -322881,19 +139565,19 @@ The modern definition of neurosecretion has evolved to include the release of an mucosa of organ of cystic duct - OBOL:automatic + OBOL:automatic mucous membrane of cystic duct - OBOL:automatic + OBOL:automatic organ mucosa of cystic duct - OBOL:automatic + OBOL:automatic @@ -322936,49 +139620,49 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a sigmoid colon [Automatically generated definition]. - OBOL:automatic + OBOL:automatic mucosa of organ of sigmoid colon - OBOL:automatic + OBOL:automatic mucous membrane of sigmoid colon - OBOL:automatic + OBOL:automatic organ mucosa of sigmoid colon - OBOL:automatic + OBOL:automatic sigmoid colon mucosa - OBOL:automatic + OBOL:automatic sigmoid colon mucosa of organ - OBOL:automatic + OBOL:automatic sigmoid colon mucous membrane - OBOL:automatic + OBOL:automatic sigmoid colon organ mucosa - OBOL:automatic + OBOL:automatic @@ -323045,193 +139729,193 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a body of stomach [Automatically generated definition]. - OBOL:automatic + OBOL:automatic body of stomach mucosa - OBOL:automatic + OBOL:automatic body of stomach mucosa of organ - OBOL:automatic + OBOL:automatic body of stomach mucous membrane - OBOL:automatic + OBOL:automatic body of stomach organ mucosa - OBOL:automatic + OBOL:automatic corpus gastricum (ventriculare) mucosa - OBOL:automatic + OBOL:automatic corpus gastricum (ventriculare) mucosa of organ - OBOL:automatic + OBOL:automatic corpus gastricum (ventriculare) mucous membrane - OBOL:automatic + OBOL:automatic corpus gastricum (ventriculare) organ mucosa - OBOL:automatic + OBOL:automatic gastric body mucosa - OBOL:automatic + OBOL:automatic gastric body mucosa of organ - OBOL:automatic + OBOL:automatic gastric body mucous membrane - OBOL:automatic + OBOL:automatic gastric body organ mucosa - OBOL:automatic + OBOL:automatic mucosa of corpus gastricum (ventriculare) - OBOL:automatic + OBOL:automatic mucosa of gastric body - OBOL:automatic + OBOL:automatic mucosa of organ of body of stomach - OBOL:automatic + OBOL:automatic mucosa of organ of corpus gastricum (ventriculare) - OBOL:automatic + OBOL:automatic mucosa of organ of gastric body - OBOL:automatic + OBOL:automatic mucosa of organ of stomach body - OBOL:automatic + OBOL:automatic mucosa of stomach body - OBOL:automatic + OBOL:automatic mucous membrane of body of stomach - OBOL:automatic + OBOL:automatic mucous membrane of corpus gastricum (ventriculare) - OBOL:automatic + OBOL:automatic mucous membrane of gastric body - OBOL:automatic + OBOL:automatic mucous membrane of stomach body - OBOL:automatic + OBOL:automatic organ mucosa of body of stomach - OBOL:automatic + OBOL:automatic organ mucosa of corpus gastricum (ventriculare) - OBOL:automatic + OBOL:automatic organ mucosa of gastric body - OBOL:automatic + OBOL:automatic organ mucosa of stomach body - OBOL:automatic + OBOL:automatic stomach body mucosa - OBOL:automatic + OBOL:automatic stomach body mucosa of organ - OBOL:automatic + OBOL:automatic stomach body mucous membrane - OBOL:automatic + OBOL:automatic stomach body organ mucosa - OBOL:automatic + OBOL:automatic @@ -323304,13 +139988,13 @@ The modern definition of neurosecretion has evolved to include the release of an - BTO + BTO A mucosa that is part of a pyloric antrum [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -323322,139 +140006,139 @@ The modern definition of neurosecretion has evolved to include the release of an antrum of stomach mucosa - OBOL:automatic + OBOL:automatic antrum of stomach mucosa of organ - OBOL:automatic + OBOL:automatic antrum of stomach mucous membrane - OBOL:automatic + OBOL:automatic antrum of stomach organ mucosa - OBOL:automatic + OBOL:automatic mucosa of antrum of stomach - OBOL:automatic + OBOL:automatic mucosa of organ of antrum of stomach - OBOL:automatic + OBOL:automatic mucosa of organ of pyloric antrum - OBOL:automatic + OBOL:automatic mucosa of organ of stomach pyloric antrum - OBOL:automatic + OBOL:automatic mucosa of stomach pyloric antrum - OBOL:automatic + OBOL:automatic mucous membrane of antrum of stomach - OBOL:automatic + OBOL:automatic mucous membrane of pyloric antrum - OBOL:automatic + OBOL:automatic mucous membrane of stomach pyloric antrum - OBOL:automatic + OBOL:automatic organ mucosa of antrum of stomach - OBOL:automatic + OBOL:automatic organ mucosa of pyloric antrum - OBOL:automatic + OBOL:automatic organ mucosa of stomach pyloric antrum - OBOL:automatic + OBOL:automatic pyloric antrum mucosa - OBOL:automatic + OBOL:automatic pyloric antrum mucosa of organ - OBOL:automatic + OBOL:automatic pyloric antrum mucous membrane - OBOL:automatic + OBOL:automatic pyloric antrum organ mucosa - OBOL:automatic + OBOL:automatic stomach pyloric antrum mucosa - OBOL:automatic + OBOL:automatic stomach pyloric antrum mucosa of organ - OBOL:automatic + OBOL:automatic stomach pyloric antrum mucous membrane - OBOL:automatic + OBOL:automatic stomach pyloric antrum organ mucosa - OBOL:automatic + OBOL:automatic @@ -323522,145 +140206,145 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a pylorus [Automatically generated definition]. - OBOL:automatic + OBOL:automatic mucosa of organ of pyloric part of stomach - OBOL:automatic + OBOL:automatic mucosa of organ of pylorus - OBOL:automatic + OBOL:automatic mucosa of organ of stomach pyloric region - OBOL:automatic + OBOL:automatic mucosa of pyloric part of stomach - OBOL:automatic + OBOL:automatic mucosa of stomach pyloric region - OBOL:automatic + OBOL:automatic mucous membrane of pyloric part of stomach - OBOL:automatic + OBOL:automatic mucous membrane of pylorus - OBOL:automatic + OBOL:automatic mucous membrane of stomach pyloric region - OBOL:automatic + OBOL:automatic organ mucosa of pyloric part of stomach - OBOL:automatic + OBOL:automatic organ mucosa of pylorus - OBOL:automatic + OBOL:automatic organ mucosa of stomach pyloric region - OBOL:automatic + OBOL:automatic pyloric part of stomach mucosa - OBOL:automatic + OBOL:automatic pyloric part of stomach mucosa of organ - OBOL:automatic + OBOL:automatic pyloric part of stomach mucous membrane - OBOL:automatic + OBOL:automatic pyloric part of stomach organ mucosa - OBOL:automatic + OBOL:automatic pylorus mucosa - OBOL:automatic + OBOL:automatic pylorus mucosa of organ - OBOL:automatic + OBOL:automatic pylorus mucous membrane - OBOL:automatic + OBOL:automatic pylorus organ mucosa - OBOL:automatic + OBOL:automatic stomach pyloric region mucosa - OBOL:automatic + OBOL:automatic stomach pyloric region mucosa of organ - OBOL:automatic + OBOL:automatic stomach pyloric region mucous membrane - OBOL:automatic + OBOL:automatic stomach pyloric region organ mucosa - OBOL:automatic + OBOL:automatic @@ -323718,97 +140402,97 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a biliary tree [Automatically generated definition]. - OBOL:automatic + OBOL:automatic biliary tract mucosa - OBOL:automatic + OBOL:automatic biliary tract mucosa of organ - OBOL:automatic + OBOL:automatic biliary tract mucous membrane - OBOL:automatic + OBOL:automatic biliary tract organ mucosa - OBOL:automatic + OBOL:automatic biliary tree mucosa - OBOL:automatic + OBOL:automatic biliary tree mucosa of organ - OBOL:automatic + OBOL:automatic biliary tree mucous membrane - OBOL:automatic + OBOL:automatic biliary tree organ mucosa - OBOL:automatic + OBOL:automatic mucosa of biliary tract - OBOL:automatic + OBOL:automatic mucosa of organ of biliary tract - OBOL:automatic + OBOL:automatic mucosa of organ of biliary tree - OBOL:automatic + OBOL:automatic mucous membrane of biliary tract - OBOL:automatic + OBOL:automatic mucous membrane of biliary tree - OBOL:automatic + OBOL:automatic organ mucosa of biliary tract - OBOL:automatic + OBOL:automatic organ mucosa of biliary tree - OBOL:automatic + OBOL:automatic @@ -323860,31 +140544,31 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a common bile duct [Automatically generated definition]. - OBOL:automatic + OBOL:automatic common bile duct mucosa - OBOL:automatic + OBOL:automatic common bile duct mucosa of organ - OBOL:automatic + OBOL:automatic common bile duct mucous membrane - OBOL:automatic + OBOL:automatic common bile duct organ mucosa - OBOL:automatic + OBOL:automatic @@ -323896,67 +140580,67 @@ The modern definition of neurosecretion has evolved to include the release of an ductus choledochus (biliaris) mucosa - OBOL:automatic + OBOL:automatic ductus choledochus (biliaris) mucosa of organ - OBOL:automatic + OBOL:automatic ductus choledochus (biliaris) mucous membrane - OBOL:automatic + OBOL:automatic ductus choledochus (biliaris) organ mucosa - OBOL:automatic + OBOL:automatic mucosa of ductus choledochus (biliaris) - OBOL:automatic + OBOL:automatic mucosa of organ of common bile duct - OBOL:automatic + OBOL:automatic mucosa of organ of ductus choledochus (biliaris) - OBOL:automatic + OBOL:automatic mucous membrane of common bile duct - OBOL:automatic + OBOL:automatic mucous membrane of ductus choledochus (biliaris) - OBOL:automatic + OBOL:automatic organ mucosa of common bile duct - OBOL:automatic + OBOL:automatic organ mucosa of ductus choledochus (biliaris) - OBOL:automatic + OBOL:automatic @@ -324008,31 +140692,31 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a common hepatic duct [Automatically generated definition]. - OBOL:automatic + OBOL:automatic common hepatic duct mucosa - OBOL:automatic + OBOL:automatic common hepatic duct mucosa of organ - OBOL:automatic + OBOL:automatic common hepatic duct mucous membrane - OBOL:automatic + OBOL:automatic common hepatic duct organ mucosa - OBOL:automatic + OBOL:automatic @@ -324044,67 +140728,67 @@ The modern definition of neurosecretion has evolved to include the release of an hepatic duct mucosa - OBOL:automatic + OBOL:automatic hepatic duct mucosa of organ - OBOL:automatic + OBOL:automatic hepatic duct mucous membrane - OBOL:automatic + OBOL:automatic hepatic duct organ mucosa - OBOL:automatic + OBOL:automatic mucosa of hepatic duct - OBOL:automatic + OBOL:automatic mucosa of organ of common hepatic duct - OBOL:automatic + OBOL:automatic mucosa of organ of hepatic duct - OBOL:automatic + OBOL:automatic mucous membrane of common hepatic duct - OBOL:automatic + OBOL:automatic mucous membrane of hepatic duct - OBOL:automatic + OBOL:automatic organ mucosa of common hepatic duct - OBOL:automatic + OBOL:automatic organ mucosa of hepatic duct - OBOL:automatic + OBOL:automatic @@ -324148,49 +140832,49 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a right hepatic duct [Automatically generated definition]. - OBOL:automatic + OBOL:automatic mucosa of organ of right hepatic duct - OBOL:automatic + OBOL:automatic mucous membrane of right hepatic duct - OBOL:automatic + OBOL:automatic organ mucosa of right hepatic duct - OBOL:automatic + OBOL:automatic right hepatic duct mucosa - OBOL:automatic + OBOL:automatic right hepatic duct mucosa of organ - OBOL:automatic + OBOL:automatic right hepatic duct mucous membrane - OBOL:automatic + OBOL:automatic right hepatic duct organ mucosa - OBOL:automatic + OBOL:automatic @@ -324240,31 +140924,31 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a left hepatic duct [Automatically generated definition]. - OBOL:automatic + OBOL:automatic left hepatic duct mucosa - OBOL:automatic + OBOL:automatic left hepatic duct mucosa of organ - OBOL:automatic + OBOL:automatic left hepatic duct mucous membrane - OBOL:automatic + OBOL:automatic left hepatic duct organ mucosa - OBOL:automatic + OBOL:automatic @@ -324276,19 +140960,19 @@ The modern definition of neurosecretion has evolved to include the release of an mucosa of organ of left hepatic duct - OBOL:automatic + OBOL:automatic mucous membrane of left hepatic duct - OBOL:automatic + OBOL:automatic organ mucosa of left hepatic duct - OBOL:automatic + OBOL:automatic @@ -324307,6 +140991,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -324315,9 +141000,10 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a upper lip [Automatically generated definition]. + + FMA:59832 NCIT:C12224 - SCTID:362088009 UMLS:C0226933 mucosa of organ of upper lip mucous membrane of upper lip @@ -324335,7 +141021,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a upper lip [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -324347,49 +141033,49 @@ The modern definition of neurosecretion has evolved to include the release of an mucosa of organ of upper lip - OBOL:automatic + OBOL:automatic mucous membrane of upper lip - OBOL:automatic + OBOL:automatic organ mucosa of upper lip - OBOL:automatic + OBOL:automatic upper labial mucosa - UBERON:cjm + UBERON:cjm upper lip mucosa - OBOL:automatic + OBOL:automatic upper lip mucosa of organ - OBOL:automatic + OBOL:automatic upper lip mucous membrane - OBOL:automatic + OBOL:automatic upper lip organ mucosa - OBOL:automatic + OBOL:automatic @@ -324408,6 +141094,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -324416,9 +141103,10 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a lower lip [Automatically generated definition]. + + FMA:59833 NCIT:C12225 - SCTID:362089001 UMLS:C0226939 lower labial mucosa lower lip mucosa @@ -324436,7 +141124,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a lower lip [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -324448,49 +141136,49 @@ The modern definition of neurosecretion has evolved to include the release of an lower labial mucosa - UBERON:cjm + UBERON:cjm lower lip mucosa - OBOL:automatic + OBOL:automatic lower lip mucosa of organ - OBOL:automatic + OBOL:automatic lower lip mucous membrane - OBOL:automatic + OBOL:automatic lower lip organ mucosa - OBOL:automatic + OBOL:automatic mucosa of organ of lower lip - OBOL:automatic + OBOL:automatic mucous membrane of lower lip - OBOL:automatic + OBOL:automatic organ mucosa of lower lip - OBOL:automatic + OBOL:automatic @@ -324518,8 +141206,8 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a gallbladder [Automatically generated definition]. + FMA:14662 - SCTID:362196002 gall bladder mucosa gall bladder mucosa of organ gall bladder mucous membrane @@ -324545,97 +141233,97 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a gallbladder [Automatically generated definition]. - OBOL:automatic + OBOL:automatic gall bladder mucosa - OBOL:automatic + OBOL:automatic gall bladder mucosa of organ - OBOL:automatic + OBOL:automatic gall bladder mucous membrane - OBOL:automatic + OBOL:automatic gall bladder organ mucosa - OBOL:automatic + OBOL:automatic gallbladder mucosa - OBOL:automatic + OBOL:automatic gallbladder mucosa of organ - OBOL:automatic + OBOL:automatic gallbladder mucous membrane - OBOL:automatic + OBOL:automatic gallbladder organ mucosa - OBOL:automatic + OBOL:automatic mucosa of gall bladder - OBOL:automatic + OBOL:automatic mucosa of organ of gall bladder - OBOL:automatic + OBOL:automatic mucosa of organ of gallbladder - OBOL:automatic + OBOL:automatic mucous membrane of gall bladder - OBOL:automatic + OBOL:automatic mucous membrane of gallbladder - OBOL:automatic + OBOL:automatic organ mucosa of gall bladder - OBOL:automatic + OBOL:automatic organ mucosa of gallbladder - OBOL:automatic + OBOL:automatic @@ -324648,12 +141336,296 @@ The modern definition of neurosecretion has evolved to include the release of an tunica mucosa vesicae biliaris FMA:14662 - FMA:TA + FMA:TA + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a bronchiole [Automatically generated definition]. + + FMA:263230 + FMA:62774 + bronchiole mucosa + bronchiole mucosa of organ + bronchiole mucous membrane + bronchiole organ mucosa + lobular bronchiole mucosa + lobular bronchiole mucosa of organ + lobular bronchiole mucous membrane + lobular bronchiole organ mucosa + mucosa of lobular bronchiole + mucosa of organ of bronchiole + mucosa of organ of lobular bronchiole + mucous membrane of bronchiole + mucous membrane of lobular bronchiole + organ mucosa of bronchiole + organ mucosa of lobular bronchiole + uberon + UBERON:0005039 + mucosa of bronchiole + + + + + A mucosa that is part of a bronchiole [Automatically generated definition]. + OBOL:automatic + + + + + bronchiole mucosa + OBOL:automatic + + + + + bronchiole mucosa of organ + OBOL:automatic + + + + + bronchiole mucous membrane + OBOL:automatic + + + + + bronchiole organ mucosa + OBOL:automatic + + + + + lobular bronchiole mucosa + OBOL:automatic + + + + + lobular bronchiole mucosa of organ + OBOL:automatic + + + + + lobular bronchiole mucous membrane + OBOL:automatic + + + + + lobular bronchiole organ mucosa + OBOL:automatic + + + + + mucosa of lobular bronchiole + OBOL:automatic + + + + + mucosa of organ of bronchiole + OBOL:automatic + + + + + mucosa of organ of lobular bronchiole + OBOL:automatic + + + + + mucous membrane of bronchiole + OBOL:automatic + + + + + mucous membrane of lobular bronchiole + OBOL:automatic + + + + + organ mucosa of bronchiole + OBOL:automatic + + + + + organ mucosa of lobular bronchiole + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a terminal bronchiole [Automatically generated definition]. + FMA:263232 + bronchiolus terminalis mucosa + bronchiolus terminalis mucosa of organ + bronchiolus terminalis mucous membrane + bronchiolus terminalis organ mucosa + mucosa of bronchiolus terminalis + mucosa of organ of bronchiolus terminalis + mucosa of organ of terminal bronchiole + mucous membrane of bronchiolus terminalis + mucous membrane of terminal bronchiole + organ mucosa of bronchiolus terminalis + organ mucosa of terminal bronchiole + terminal bronchiole mucosa + terminal bronchiole mucosa of organ + terminal bronchiole mucous membrane + terminal bronchiole organ mucosa + uberon + UBERON:0005040 + mucosa of terminal bronchiole + + + + + A mucosa that is part of a terminal bronchiole [Automatically generated definition]. + OBOL:automatic + + + + + bronchiolus terminalis mucosa + OBOL:automatic + + + + + bronchiolus terminalis mucosa of organ + OBOL:automatic + + + + + bronchiolus terminalis mucous membrane + OBOL:automatic + + + + + bronchiolus terminalis organ mucosa + OBOL:automatic + + + + + mucosa of bronchiolus terminalis + OBOL:automatic + + + + + mucosa of organ of bronchiolus terminalis + OBOL:automatic + + + + + mucosa of organ of terminal bronchiole + OBOL:automatic + + + + + mucous membrane of bronchiolus terminalis + OBOL:automatic + + + + + mucous membrane of terminal bronchiole + OBOL:automatic + + + + + organ mucosa of bronchiolus terminalis + OBOL:automatic + + + + + organ mucosa of terminal bronchiole + OBOL:automatic + + + + + terminal bronchiole mucosa + OBOL:automatic + + + + + terminal bronchiole mucosa of organ + OBOL:automatic + + + + + terminal bronchiole mucous membrane + OBOL:automatic + + + + + terminal bronchiole organ mucosa + OBOL:automatic + + + + @@ -324679,10 +141651,10 @@ The modern definition of neurosecretion has evolved to include the release of an An external genitalia that is part of a female reproductive system [Automatically generated definition]. in eutherians, this is known as the vulva in and composed of the mons pubis, the labia majora and minora, the clitoris, the vestibule of the vagina and its glands, and the opening of the urethra and of the vagina [MP:0003126] + BTO:0003100 EMAPA:30984 FMA:45649 - SCTID:362234008 galen:FemaleExternalGenitalia external female genital organ external genitalia of female reproductive system @@ -324699,7 +141671,7 @@ The modern definition of neurosecretion has evolved to include the release of an An external genitalia that is part of a female reproductive system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -324711,7 +141683,7 @@ The modern definition of neurosecretion has evolved to include the release of an external genitalia of female reproductive system - OBOL:automatic + OBOL:automatic @@ -324761,7 +141733,7 @@ The modern definition of neurosecretion has evolved to include the release of an An organ that is part of a immune system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -324802,7 +141774,7 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that is part of a hemolymphoid system [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -324814,7 +141786,7 @@ The modern definition of neurosecretion has evolved to include the release of an hemopoietic or lymphoid gland - http://orcid.org/0000-0002-6601-2165 + @@ -324828,6 +141800,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -324837,13 +141810,14 @@ The modern definition of neurosecretion has evolved to include the release of an The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds. The neural groove is a shallow median groove between the neural folds of an embryo. The neural folds are two longitudinal ridges that are caused by a folding up of the ectoderm in front of the primitive streak of the developing embryo. The groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or canal, the ectodermal wall of which forms the rudiment of the nervous system. After the coalescence of the neural folds over the anterior end of the primitive streak, the blastopore no longer opens on the surface but into the closed canal of the neural tube, and thus a transitory communication, the neurenteric canal, is established between the neural tube and the primitive digestive tube. The coalescence of the neural folds occurs first in the region of the hind-brain, and from there extends forward and backward; toward the end of the third week the front opening (anterior neuropore) of the tube finally closes at the anterior end of the future brain, and forms a recess which is in contact, for a time, with the overlying ectoderm; the hinder part of the neural groove presents for a time a rhomboidal shape, and to this expanded portion the term sinus rhomboidalis has been applied. Before the neural groove is closed a ridge of ectodermal cells appears along the prominent margin of each neural fold; this is termed the neural crest or ganglion ridge, and from it the spinal and cranial nerve ganglia and the ganglia of the sympathetic nervous system are developed. By the upward growth of the mesoderm the neural tube is ultimately separated from the overlying ectoderm. The cephalic end of the neural groove exhibits several dilatations, which, when the tube is closed, assume the form of three vesicles; these constitute the three primary cerebral vesicles, and correspond respectively to the future fore-brain (prosencephalon), mid-brain (mesencephalon), and hind-brain (rhombencephalon). The walls of the vesicles are developed into the nervous tissue and neuroglia of the brain, and their cavities are modified to form its ventricles. The remainder of the tube forms the medulla spinalis or spinal cord; from its ectodermal wall the nervous and neuroglial elements of the medulla spinalis are developed while the cavity persists as the central canal[Wikipedia:Neural_groove]. + + + AAO:0011071 EMAPA:35594 FMA:295624 NCIT:C34224 - SCTID:361463007 UMLS:C0814992 - Wikipedia:Neural_groove XAO:0000248 neuronames:1363 uberon @@ -324854,15 +141828,15 @@ The modern definition of neurosecretion has evolved to include the release of an The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds. + + GO:0001842 - Wikipedia:Neural_groove - http://orcid.org/0000-0002-6601-2165 The neural groove is a shallow median groove between the neural folds of an embryo. The neural folds are two longitudinal ridges that are caused by a folding up of the ectoderm in front of the primitive streak of the developing embryo. The groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or canal, the ectodermal wall of which forms the rudiment of the nervous system. After the coalescence of the neural folds over the anterior end of the primitive streak, the blastopore no longer opens on the surface but into the closed canal of the neural tube, and thus a transitory communication, the neurenteric canal, is established between the neural tube and the primitive digestive tube. The coalescence of the neural folds occurs first in the region of the hind-brain, and from there extends forward and backward; toward the end of the third week the front opening (anterior neuropore) of the tube finally closes at the anterior end of the future brain, and forms a recess which is in contact, for a time, with the overlying ectoderm; the hinder part of the neural groove presents for a time a rhomboidal shape, and to this expanded portion the term sinus rhomboidalis has been applied. Before the neural groove is closed a ridge of ectodermal cells appears along the prominent margin of each neural fold; this is termed the neural crest or ganglion ridge, and from it the spinal and cranial nerve ganglia and the ganglia of the sympathetic nervous system are developed. By the upward growth of the mesoderm the neural tube is ultimately separated from the overlying ectoderm. The cephalic end of the neural groove exhibits several dilatations, which, when the tube is closed, assume the form of three vesicles; these constitute the three primary cerebral vesicles, and correspond respectively to the future fore-brain (prosencephalon), mid-brain (mesencephalon), and hind-brain (rhombencephalon). The walls of the vesicles are developed into the nervous tissue and neuroglia of the brain, and their cavities are modified to form its ventricles. The remainder of the tube forms the medulla spinalis or spinal cord; from its ectodermal wall the nervous and neuroglial elements of the medulla spinalis are developed while the cavity persists as the central canal[Wikipedia:Neural_groove]. - Wikipedia:Neural_groove + @@ -324895,12 +141869,13 @@ The modern definition of neurosecretion has evolved to include the release of an One of the two elevated edges of the neural groove[GO,MP]. In front of the primitive streak two longitudinal ridges, caused by a folding up of the ectoderm, make their appearance, one on either side of the middle line. These are named the neural folds; they commence some little distance behind the anterior end of the embryonic disk, where they are continuous with each other, and from there gradually extend backward, one on either side of the anterior end of the primitive streak. Also, after differentiation it turns into the neural tubes[Wikipedia:Neural_fold]. + + + EHDAA2:0001249 FMA:295618 NCIT:C34223 - SCTID:361461009 UMLS:C0814993 - Wikipedia:Neural_fold XAO:0004087 neuronames:1364 medullary fold @@ -324913,15 +141888,15 @@ The modern definition of neurosecretion has evolved to include the release of an One of the two elevated edges of the neural groove[GO,MP]. + GO:0001842 MP:0011256 - Wikipedia:Neural_fold In front of the primitive streak two longitudinal ridges, caused by a folding up of the ectoderm, make their appearance, one on either side of the middle line. These are named the neural folds; they commence some little distance behind the anterior end of the embryonic disk, where they are continuous with each other, and from there gradually extend backward, one on either side of the anterior end of the primitive streak. Also, after differentiation it turns into the neural tubes[Wikipedia:Neural_fold]. - Wikipedia:Neural_fold + @@ -324965,7 +141940,6 @@ The modern definition of neurosecretion has evolved to include the release of an - . uberon UBERON:0005064 left ventricular trabecular myocardium @@ -324979,13 +141953,7 @@ The modern definition of neurosecretion has evolved to include the release of an - GO - - - - - . - GO:0003225 + GO @@ -325017,7 +141985,6 @@ The modern definition of neurosecretion has evolved to include the release of an - . uberon UBERON:0005066 right ventricular trabecular myocardium @@ -325031,13 +141998,7 @@ The modern definition of neurosecretion has evolved to include the release of an - GO - - - - - . - GO:0003227 + GO @@ -325080,10 +142041,10 @@ The modern definition of neurosecretion has evolved to include the release of an An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000133 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -325142,7 +142103,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord. - OBOL:automatic + OBOL:automatic @@ -325189,6 +142150,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -325217,7 +142179,7 @@ The modern definition of neurosecretion has evolved to include the release of an in GO, covers optic, otic, olfactory, mammary, hair, tooth, sebaceous - and also insect structures GO - https://github.com/geneontology/go-ontology/issues/12223#issuecomment-215692347 + @@ -325232,6 +142194,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -325273,6 +142236,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -325301,17 +142265,17 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Three major adaptations, or 'novel cardiac components', that were not present in the ancestor chordate heart tube can be distinguished in the lower vertebrate heart: the atrium, ventricle, and possibly the muscular sinus venosus.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000489 - VHOG + VHOG + DOI:10.1152/physrev.00006.2003 Moorman AFM, Christoffels VM, Cardiac Chamber Formation: Development, Genes, and Evolution. Physiological Reviews (2003 - http://bgee.unil.ch/ @@ -325374,7 +142338,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any anatomical structure that is part of the reproductive system. - http://orcid.org/0000-0002-6601-2165 + @@ -325434,26 +142398,26 @@ The modern definition of neurosecretion has evolved to include the release of an The functional tissue of the central nervous system consisting of neurons and glial cells. + CL:tm - https://github.com/obophenotype/uberon/issues/8 CNS parenchyma - OBOL:automatic + OBOL:automatic central nervous system parenchyma - OBOL:automatic + OBOL:automatic parenchyma of CNS - OBOL:automatic + OBOL:automatic @@ -325461,7 +142425,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + + @@ -325482,6 +142447,12 @@ The modern definition of neurosecretion has evolved to include the release of an multi cell part structure + + + + + FMA + @@ -325493,7 +142464,7 @@ The modern definition of neurosecretion has evolved to include the release of an we go with the FMA classification rather than the CARO one. FMA def: 'Anatomical cluster which has as direct parts cell parts from two or more cells.' CARO - FMA + FMA @@ -325543,13 +142514,15 @@ The modern definition of neurosecretion has evolved to include the release of an A duct that carries bile from the liver to the small intestine.[TAO] The excretory duct of the liver or one of its branches in the lobes of the liver. [TFD][VHOG] The hepatic duct is the duct that leads from the liver to the bile duct[GO]. + + EHDAA2:0000741 EHDAA:3049 EMAPA:16843 FMA:71891 MA:0000357 NCIT:C32730 - SCTID:245399002 + OpenCyc:Mx4rvWo8WJwpEbGdrcN5Y29ycA UMLS:C0917710 VHOG:0000219 galen:HepaticDuct @@ -325563,26 +142536,26 @@ The modern definition of neurosecretion has evolved to include the release of an Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion). - http://orcid.org/0000-0002-6601-2165 + A duct that carries bile from the liver to the small intestine.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001100 - TAO - ZFIN:curator + TAO + ZFIN:curator The excretory duct of the liver or one of its branches in the lobes of the liver. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000219 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/hepatic+duct + VHOG + + @@ -325621,8 +142594,8 @@ The modern definition of neurosecretion has evolved to include the release of an An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland. + MA:0000522 - SCTID:272631008 abdomen organ uberon UBERON:0005172 @@ -325633,7 +142606,7 @@ The modern definition of neurosecretion has evolved to include the release of an An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland. - http://orcid.org/0000-0002-6601-2165 + @@ -325678,13 +142651,13 @@ The modern definition of neurosecretion has evolved to include the release of an An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region. - http://orcid.org/0000-0002-6601-2165 + EMAPA:37062 - MA:th + MA:th @@ -325730,13 +142703,13 @@ The modern definition of neurosecretion has evolved to include the release of an An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back. - http://orcid.org/0000-0002-6601-2165 + EMAPA:37274 - MA:th + MA:th @@ -325782,13 +142755,13 @@ The modern definition of neurosecretion has evolved to include the release of an An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions. - http://orcid.org/0000-0002-6601-2165 + EMAPA:37270 - MA:th + MA:th @@ -325841,13 +142814,13 @@ The modern definition of neurosecretion has evolved to include the release of an An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli. - http://orcid.org/0000-0002-6601-2165 + EMAPA:37273 - MA:th + MA:th @@ -325896,13 +142869,13 @@ The modern definition of neurosecretion has evolved to include the release of an An organ or element that is part of the pelvic region. Examples: reproductive organs (in some organisms), urinary bladder, bones of the pelvis. - http://orcid.org/0000-0002-6601-2165 + EMAPA:37275 - MA:th + MA:th @@ -325947,13 +142920,13 @@ The modern definition of neurosecretion has evolved to include the release of an An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions. - http://orcid.org/0000-0002-6601-2165 + EMAPA:37271 - MA:th + MA:th @@ -325987,10 +142960,11 @@ The modern definition of neurosecretion has evolved to include the release of an A vein that is part of a thorax [Automatically generated definition]. + + EMAPA:37197 MA:0002235 NCIT:C53142 - SCTID:281472008 UMLS:C0226629 uberon UBERON:0005194 @@ -326000,13 +142974,13 @@ The modern definition of neurosecretion has evolved to include the release of an A vein that is part of a thorax [Automatically generated definition]. - OBOL:automatic + OBOL:automatic EMAPA:37197 - MA:th + MA:th @@ -326017,6 +142991,85 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen. + + These glands secrete mucus, lysozyme, defensins, and other agents that help protect the lungs from particles and infectious agents. + + EMAPA:36574 + FMA:7473 + MA:0002937 + glandula trachealis + tracheal gland + uberon + tubular seromucous gland of trachea + UBERON:0005203 + + + + trachea gland + + + + + A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen. + + + + ISBN:1451113412 + MGI:Anna + + + + + glandula trachealis + FMA:7473 + + + + + tracheal gland + FMA:7473 + + + + + tubular seromucous gland of trachea + FMA:7473 + + + + @@ -326061,14 +143114,14 @@ The modern definition of neurosecretion has evolved to include the release of an - true - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + true + An external ectoderm that is part of a optic eminence [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -326108,7 +143161,7 @@ The modern definition of neurosecretion has evolved to include the release of an A parenchyma that is part of a right lobe of liver [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -326154,7 +143207,7 @@ The modern definition of neurosecretion has evolved to include the release of an A parenchyma that is part of a left lobe of liver [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -326207,7 +143260,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -326218,13 +143271,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 An ectoderm that is part of a medial nasal prominence [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -326263,7 +143316,7 @@ The modern definition of neurosecretion has evolved to include the release of an An ectoderm that is part of a optic eminence [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -326285,10 +143338,10 @@ The modern definition of neurosecretion has evolved to include the release of an The ventral half of the developing neural tube that is the metencephalon. [Chordate_evolution_and_the_origin_of_craniates:_An_old_brain_in_a_new_head._AnaT_Rec_(New_Anat)_(2000)_261(3):_111-125, See_Butler_AB][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000320 - VHOG - http://bgee.unil.ch/ + VHOG + @@ -326336,7 +143389,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endocardium that is part of a interventricular septum [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -326386,7 +143439,7 @@ The modern definition of neurosecretion has evolved to include the release of an A myocardium that is part of a bulbus cordis [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -326411,6 +143464,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -326431,7 +143485,7 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that is part of a stomodeum. - OBOL:automatic + OBOL:automatic @@ -326488,19 +143542,19 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical cavity that is part of a yolk sac [Automatically generated definition]. - OBOL:automatic + OBOL:automatic In mammals, the yolk sac cavity contains fluid rather than platelets - ISBN:0073040584 + ISBN:0073040584 in EHDAA2, there are separate primary and secondary yolk sac cavities - EHDAA2 + EHDAA2 @@ -326575,7 +143629,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -326588,10 +143642,10 @@ The modern definition of neurosecretion has evolved to include the release of an Mesoderm that will give rise, along with cranial neural crest cells, to connective tissue, bone and musculature in the head. (Source: BioGlossary, www.Biology-Text.com)[TAO] - 2012-08-14 + 2012-08-14 TAO:0000113 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -326603,7 +143657,7 @@ The modern definition of neurosecretion has evolved to include the release of an cranial mesenchyme - MGI:anna + MGI:anna @@ -326677,13 +143731,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that is part of a developing trunk. - OBOL:automatic + OBOL:automatic @@ -326721,6 +143775,7 @@ The modern definition of neurosecretion has evolved to include the release of an The posterior of the two brain vesicles formed by specialization of the rhombencephalon in the developing embryo, it comprises the medulla oblongata. [TFD][VHOG] The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG] the terms metencephalon and myelencephalon are only meaningful in mammals and birds - Neuroanatomy of the Zebrafish Brain. Note that its not clear if this refers to the developing medulla oblongata - MA (adult) has two distinct classes + BTO:0000758 CALOHA:TS-0607 CALOHA:TS-2365 @@ -326732,13 +143787,12 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000205 MESH:D054024 VHOG:0000456 - Wikipedia:Myelencephalon uberon myelencephalon (medulla oblongata) UBERON:0005290 myelencephalon - http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg + http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg @@ -326749,34 +143803,34 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]. + BTO:0000758 - Wikipedia:Myelencephalon The posterior of the two brain vesicles formed by specialization of the rhombencephalon in the developing embryo, it comprises the medulla oblongata. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000456 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/myelencephalon + VHOG + + The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000456 - VHOG + VHOG + ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500 - http://bgee.unil.ch/ @@ -326828,13 +143882,13 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of tissue that is part of an embryo. - OBOL:automatic + OBOL:automatic portion of embryonic tissue - OBOL:automatic + OBOL:automatic @@ -326854,6 +143908,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -326876,7 +143931,7 @@ The modern definition of neurosecretion has evolved to include the release of an Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo. - https://orcid.org/0000-0002-6601-2165 + @@ -326914,7 +143969,7 @@ The modern definition of neurosecretion has evolved to include the release of an The endothelial lining of the endocardium. - UBERON:cjm + UBERON:cjm @@ -326946,6 +144001,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -326989,6 +144045,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -327006,7 +144063,7 @@ The modern definition of neurosecretion has evolved to include the release of an A lamina propria that is part of a mucosa of oral region. - OBOL:automatic + OBOL:automatic @@ -327033,8 +144090,8 @@ The modern definition of neurosecretion has evolved to include the release of an A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP]. + FMA:13225 - Wikipedia:Ventricular_outflow_tract XAO:0004140 heart ventricle outflow tract outflow part of ventricle @@ -327047,7 +144104,7 @@ The modern definition of neurosecretion has evolved to include the release of an A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP]. - Wikipedia:Ventricular_outflow_tract + @@ -327059,7 +144116,7 @@ The modern definition of neurosecretion has evolved to include the release of an ventricular outflow tract - Wikipedia:Ventricular_outflow_tract + @@ -327099,7 +144156,7 @@ The modern definition of neurosecretion has evolved to include the release of an An outflow tract that is part of a aorta. - OBOL:automatic + OBOL:automatic @@ -327139,6 +144196,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -327169,7 +144227,7 @@ The modern definition of neurosecretion has evolved to include the release of an An array of photoreceptors and any supporting cells found in an eye. - https://orcid.org/0000-0002-6601-2165 + @@ -327202,7 +144260,7 @@ The modern definition of neurosecretion has evolved to include the release of an A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array. - http://orcid.org/0000-0002-6601-2165 + @@ -327214,6 +144272,10 @@ The modern definition of neurosecretion has evolved to include the release of an One of: the common carotid artery, or its branches, the external and internal carotid arteries. This is a generic grouping class that is the superclass of the trunks/branches of the common carotid artery. Note that AOs vary widely in how they divide up and generalize arteries Artery originating at the junction of the first two aortic arches and supplying the anterior brain. Kimmel et al, 1995.[TAO] + + + + AAO:0010217 BTO:0000168 CALOHA:TS-0116 @@ -327227,12 +144289,10 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000501 MESH:D002339 NCIT:C12687 - SCTID:362040006 - SCTID:69105007 + OpenCyc:Mx4rvg7rcJwpEbGdrcN5Y29ycA TAO:0000097 UMLS:C0007272 VHOG:0000266 - Wikipedia:Carotid_artery ZFA:0000097 galen:CarotidArtery carotid @@ -327251,23 +144311,23 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA One of: the common carotid artery, or its branches, the external and internal carotid arteries. - Wikipedia:Carotid_artery - https://sourceforge.net/tracker/?func=detail&aid=3486870&group_id=76834&atid=994764 + + Artery originating at the junction of the first two aortic arches and supplying the anterior brain. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000097 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -327342,7 +144402,7 @@ The modern definition of neurosecretion has evolved to include the release of an A sex gland that is part of a female reproductive system. - OBOL:automatic + OBOL:automatic @@ -327368,6 +144428,8 @@ The modern definition of neurosecretion has evolved to include the release of an The system that includes the esophagus, stomach, small and large intestine, anus, liver, biliary tract, and pancreas[ncithesaurus:Gastrointestinal_System]. All metazoans (with degenerate exceptions) have some sort of digestive cavity with a means of entrance to and exit from it.[well established][VHOG] that many anatomy ontologies consider this synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class. We have one entity that is part of both gastrointestinal and hepatobiliary systems: hepatopancreatic ampulla. + + BTO:0000058 CALOHA:TS-0407 EHDAA2:0000110 @@ -327379,7 +144441,6 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0000323 MESH:D041981 NCIT:C12378 - SCTID:373871007 UMLS:C0012240 VHOG:0000412 galen:GastrointestinalTract @@ -327400,7 +144461,7 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the digestive system that excludes the hepatobiliary system. - http://orcid.org/0000-0002-6601-2165 + @@ -327412,17 +144473,17 @@ The modern definition of neurosecretion has evolved to include the release of an All metazoans (with degenerate exceptions) have some sort of digestive cavity with a means of entrance to and exit from it.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000412 - VHOG + VHOG + ISBN:978-0721676685 Sherwood Romer A and Parsons T, Vertebrate body (1977) p.3 - http://bgee.unil.ch/ that many anatomy ontologies consider this synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class. We have one entity that is part of both gastrointestinal and hepatobiliary systems: hepatopancreatic ampulla. - MA + MA @@ -327458,7 +144519,7 @@ The modern definition of neurosecretion has evolved to include the release of an gastroenterological system - UBERON:cjm + UBERON:cjm @@ -327536,26 +144597,26 @@ The modern definition of neurosecretion has evolved to include the release of an A limb bud that develops into a forelimb or pectoral fin. - OBOL:automatic + OBOL:automatic Fin bud that develops into the pectoral fin.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000141 - TAO - ZFIN:curator + TAO + ZFIN:curator While the skeletons of teleost pectoral fins and tetrapod forelimbs are homologous at the level of endoskeletal radials, teleosts and tetrapods do not share homologous skeletal elements at the level of 'individuated' pro-, meso-, and metapterygia. Among osteichthyans, only basal actinopterygians retain the full complement of elements present in non-osteichthyan gnathostomes.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001754 - VHOG + VHOG + DOI:10.1002/jmor.10264 Davis MC, Shubin NH, Force A, Pectoral fin and girdle development in the basal actinopterygians Polyodon spathula and Acipenser transmontanus. Journal of Morphology (2004) - http://bgee.unil.ch/ @@ -327574,7 +144635,7 @@ The modern definition of neurosecretion has evolved to include the release of an pectoral fin buds TAO:0000141 - + @@ -327653,32 +144714,32 @@ The modern definition of neurosecretion has evolved to include the release of an A limb bud that develops into a hindlimb or pelvic fin. - OBOL:automatic + OBOL:automatic - PMID:15893975 + Fin bud that develops into the pelvic fin.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001384 - TAO - ZFIN:curator + TAO + ZFIN:curator Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001260 - VHOG + VHOG + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 - http://bgee.unil.ch/ @@ -327697,7 +144758,7 @@ The modern definition of neurosecretion has evolved to include the release of an pelvic fin buds ZFA:0001384 - + @@ -327764,42 +144825,42 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 An apical ectodermal ridge that is part of a pectoral appendage bud. - OBOL:automatic + OBOL:automatic An ectodermal thickening at the end of the forelimb bud in the developing embryo. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001064 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/apical+ectodermal+ridge + VHOG + + Apical ectodermal ridge that is part of the pectoral fin bud.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000085 - TAO - ZFIN:curator + TAO + ZFIN:curator Pectoral and pelvic fins are homologous to the tetrapod fore and hindlimb, respectively. (...) The zebrafish AER [apical ectodermal ridge] is an apical ectodermal thickening at the distal tip of the fin bud and consists of wedge-shaped cells of the basal stratum. The AER is observed only transiently, and from 36 hpf onwards the cells of this region form the apical fold (AF), which consists of a dorsal and a ventral layer of cylindrically-shaped ectodermal cells extending from the anterior to the posterior fin margin. Despite the change in shape, the AF still carries out the same functions as the AER. Indeed, although the AER receives its name from its characteristic shape, being composed of a pseudostratified ectoderm in the chicken and a polystratified ectoderm in the mouse, this independence of AER morphology from its function is also observed in tetrapods. The AF also expresses similar molecular markers to the tetrapod AER, suggesting that it fulfills similar functions in the fin as the AER does in tetrapod limbs.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001064 - VHOG - DOI:10.1111/j.1440-169X.2007.00942.x - http://bgee.unil.ch/ + VHOG + + @@ -327917,42 +144978,42 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 An apical ectodermal ridge that is part of a pelvic appendage bud. - OBOL:automatic + OBOL:automatic An ectodermal thickening at the end of the hindlimb bud in the developing embryo. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001066 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/apical+ectodermal+ridge + VHOG + + Apical ectodermal ridge that is part of the pelvic fin bud.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001385 - TAO + TAO ZIFIN:curator Pectoral and pelvic fins are homologous to the tetrapod fore and hindlimb, respectively. (...) The zebrafish AER [apical ectodermal ridge] is an apical ectodermal thickening at the distal tip of the fin bud and consists of wedge-shaped cells of the basal stratum. The AER is observed only transiently, and from 36 hpf onwards the cells of this region form the apical fold (AF), which consists of a dorsal and a ventral layer of cylindrically-shaped ectodermal cells extending from the anterior to the posterior fin margin. Despite the change in shape, the AF still carries out the same functions as the AER. Indeed, although the AER receives its name from its characteristic shape, being composed of a pseudostratified ectoderm in the chicken and a polystratified ectoderm in the mouse, this independence of AER morphology from its function is also observed in tetrapods. The AF also expresses similar molecular markers to the tetrapod AER, suggesting that it fulfills similar functions in the fin as the AER does in tetrapod limbs.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001066 - VHOG - DOI:10.1111/j.1440-169X.2007.00942.x - http://bgee.unil.ch/ + VHOG + + @@ -327997,9 +145058,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - AEO:0000125 CALOHA:TS-2122 EHDAA2:0003125 @@ -328011,7 +145069,6 @@ The modern definition of neurosecretion has evolved to include the release of an developmental structure developmental tissue UBERON:0005423 - developing anatomical structure @@ -328076,17 +145133,17 @@ The modern definition of neurosecretion has evolved to include the release of an Portion of tissue that is the inner layer of the optic cup and will become the neural retina. - ZFIN:curator + ZFIN:curator (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000490 - VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 - http://bgee.unil.ch/ + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 @@ -328105,7 +145162,7 @@ The modern definition of neurosecretion has evolved to include the release of an presumptive retinas ZFA:0001071 - + @@ -328143,10 +145200,10 @@ The modern definition of neurosecretion has evolved to include the release of an A vesicle formed from the lens pit of the embryo, developing into the crystalline lens. [TFD][VHOG] (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG] the lens of zebrafish (and other teleosts) forms from delamination of cells from the lens placode; thus, there is no formation of a hollow lens vesicle, in contrast to the situation in mammals and birds (Glass and Dahm, 2004) [PMID:16496288] The lens of the zebrafish forms by delamination of lens placodal cells and not through invagination. This results in a solid spherical mass as opposed to a hollow lens vesicle. Detachment of the solid lens vesicle of zebrafish at 24b26 hpf is accomplished in part by apoptosis, similar to mammals + EHDAA2:0000983 EHDAA:4737 EMAPA:17163 - SCTID:361510002 TAO:0002205 VHOG:0001163 ZFA:0001679 @@ -328165,34 +145222,34 @@ The modern definition of neurosecretion has evolved to include the release of an Portion of tissue that gives rise to the lens. - ZFIN:curator - https://sourceforge.net/tracker/?func=detail&atid=994726&aid=3514998&group_id=76834 + + ZFIN:curator A vesicle formed from the lens pit of the embryo, developing into the crystalline lens. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001163 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/lens+vesicle + VHOG + + (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001163 - VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 - http://bgee.unil.ch/ + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 the lens of zebrafish (and other teleosts) forms from delamination of cells from the lens placode; thus, there is no formation of a hollow lens vesicle, in contrast to the situation in mammals and birds (Glass and Dahm, 2004) [PMID:16496288] The lens of the zebrafish forms by delamination of lens placodal cells and not through invagination. This results in a solid spherical mass as opposed to a hollow lens vesicle. Detachment of the solid lens vesicle of zebrafish at 24b26 hpf is accomplished in part by apoptosis, similar to mammals - ZFA + ZFA @@ -328259,13 +145316,13 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA - Obol + Obol @@ -328276,7 +145333,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -328320,26 +145377,26 @@ The modern definition of neurosecretion has evolved to include the release of an Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA]. - ZFIN:curator + ZFIN:curator Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000818 - TAO - ZFIN:curator + TAO + ZFIN:curator We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001208 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 - http://bgee.unil.ch/ @@ -328352,7 +145409,7 @@ The modern definition of neurosecretion has evolved to include the release of an VNC XAO:0004191 - + @@ -328369,6 +145426,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -328389,12 +145447,12 @@ The modern definition of neurosecretion has evolved to include the release of an The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates. the merged ventral aortae of the embryo which supplies blood to the aortic arches[TMD][http://medical-dictionary.thefreedictionary.com/aortic+sac]. + EHDAA2:0004145 EHDAA:9826 EMAPA:36461 FMA:71008 RETIRED_EHDAA2:0000133 - SCTID:361527005 saccus aorticus uberon UBERON:0005432 @@ -328405,7 +145463,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -328416,7 +145474,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -328428,7 +145486,7 @@ The modern definition of neurosecretion has evolved to include the release of an the merged ventral aortae of the embryo which supplies blood to the aortic arches[TMD][http://medical-dictionary.thefreedictionary.com/aortic+sac]. - http://medical-dictionary.thefreedictionary.com/aortic+sac + @@ -328455,8 +145513,8 @@ The modern definition of neurosecretion has evolved to include the release of an + FMA:24219 - SCTID:123958008 cervical region neck subdivision region of neck @@ -328499,24 +145557,24 @@ The modern definition of neurosecretion has evolved to include the release of an - + - + In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine) and pancreas. It arises from the celiac artery and has the following branches:. + + EHDAA2:0000308 EHDAA:8570 EMAPA:37206 FMA:14771 MA:0003094 - SCTID:244263001 - Wikipedia:Common_hepatic_artery galen:CommonHepaticArtery uberon arteria hepatica communis @@ -328524,34 +145582,32 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0005436 common hepatic artery - http://upload.wikimedia.org/wikipedia/commons/6/65/Gray532.png - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb + http://upload.wikimedia.org/wikipedia/commons/6/65/Gray532.png In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine) and pancreas. It arises from the celiac artery and has the following branches:. - Wikipedia:Common_hepatic_artery + EMAPA:37206 - MA:th + MA:th arteria hepatica communis - Wikipedia:Common_hepatic_artery + common hepatic - Wikipedia:Common_hepatic_artery + @@ -328568,7 +145624,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -328584,7 +145640,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -328592,64 +145648,64 @@ The modern definition of neurosecretion has evolved to include the release of an A circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa.vity. [Wikipedia:Foramen_rotundum][VHOG] It is suggested that the mammalian lamina ascendens arose from an upgrowth of the root of the quadrate ramus of the epipterygoid in cynodonts, separating foramen rotundum from foramen ovale.[well established][VHOG] todo - check placement of AAO class + + AAO:0000194 EHDAA2:0000552 EHDAA:10629 EMAPA:18712 FMA:53154 - SCTID:369439002 VHOG:0001543 - Wikipedia:Foramen_rotundum uberon foramen rotundum of the skull foramen rotundum ossis sphenoidalis round foramen UBERON:0005446 foramen rotundum - http://upload.wikimedia.org/wikipedia/commons/3/35/Gray145.png + http://upload.wikimedia.org/wikipedia/commons/3/35/Gray145.png The foramen rotundum is a circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa. - Wikipedia:Foramen_rotundum + A circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa.vity. [Wikipedia:Foramen_rotundum][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001543 - VHOG - http://bgee.unil.ch/ + VHOG + It is suggested that the mammalian lamina ascendens arose from an upgrowth of the root of the quadrate ramus of the epipterygoid in cynodonts, separating foramen rotundum from foramen ovale.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001543 - VHOG + VHOG + PMID:1018003 Presley R, Steel FLD, On the homology of the alisphenoid. Journal of Anatomy (1976) - http://bgee.unil.ch/ todo - check placement of AAO class - AAO + AAO foramen rotundum of the skull - Wikipedia:Foramen_rotundum + foramen rotundum ossis sphenoidalis - Wikipedia:Foramen_rotundum + @@ -328685,11 +145741,11 @@ The modern definition of neurosecretion has evolved to include the release of an A vitelline vein that is in the left side of a multicellular organism. https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern + EHDAA2:0000971 EMAPA:16380 EMAPA:16698 FMA:70307 - SCTID:361446008 uberon UBERON:0005460 left vitelline vein @@ -328698,7 +145754,7 @@ The modern definition of neurosecretion has evolved to include the release of an A vitelline vein that is in the left side of a multicellular organism. - OBOL:automatic + OBOL:automatic @@ -328727,11 +145783,11 @@ The modern definition of neurosecretion has evolved to include the release of an A vitelline vein that is in the right side of a multicellular organism. https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern + EHDAA2:0001766 EMAPA:16381 EMAPA:16699 FMA:70306 - SCTID:361445007 uberon UBERON:0005472 right vitelline vein @@ -328740,7 +145796,7 @@ The modern definition of neurosecretion has evolved to include the release of an A vitelline vein that is in the right side of a multicellular organism. - OBOL:automatic + OBOL:automatic @@ -328748,6 +145804,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -328774,14 +145831,14 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD]. - http://medical-dictionary.thefreedictionary.com/Sulcus+limitans - http://www.ncbi.nlm.nih.gov/books/NBK10047 + + @@ -328824,15 +145881,16 @@ The modern definition of neurosecretion has evolved to include the release of an One of two veins that run upward at first in front, and subsequently on either side of the intestinal canal. They unite on the ventral aspect of the canal, and beyond this are connected to one another by two anastomotic branches, one on the dorsal, and the other on the ventral aspect of the duodenal portion of the intestine, which is thus encircled by two venous rings; into the middle or dorsal anastomosis the superior mesenteric vein opens. The portions of the veins above the upper ring become interrupted by the developing liver and broken up by it into a plexus of small capillary-like vessels termed sinusoids.[XAO] Within each vertebrate group, the veins compose a few main functional systems that arise embryologically from what seems to be a common developmental pattern. (...) Early in development, three major sets of paired veins are present: the vitelline veins from the yolk sac, the cardinal veins from the body of the embryo itself, and the lateral abdominal veins from the pelvic region. The paired vitelline veins are among the first vessels to appear in the embryo. They arise over the yolk and follow the yolk stalk into the body. They then turn anteriorly, continue along the gut, and enter the sinus venosus.[well established][VHOG] check zfa (no text def). Check vitelline/omphalomesenteric distinction in XAO + + + + EMAPA:36021 FMA:70305 NCIT:C34329 RETIRED_EHDAA2:0002209 - SCTID:2730004 - SCTID:308832003 UMLS:C0231091 VHOG:0000401 - Wikipedia:Vitelline_veins XAO:0000376 XAO:0004147 embryonic vitelline vein @@ -328846,13 +145904,13 @@ The modern definition of neurosecretion has evolved to include the release of an vitelline vein - http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray475.png + http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray475.png The paired veins that carry blood from the yolk sac back to the embryo. - MGI:csmith + MGI:csmith MP:0010666 @@ -328866,11 +145924,11 @@ The modern definition of neurosecretion has evolved to include the release of an Within each vertebrate group, the veins compose a few main functional systems that arise embryologically from what seems to be a common developmental pattern. (...) Early in development, three major sets of paired veins are present: the vitelline veins from the yolk sac, the cardinal veins from the body of the embryo itself, and the lateral abdominal veins from the pelvic region. The paired vitelline veins are among the first vessels to appear in the embryo. They arise over the yolk and follow the yolk stalk into the body. They then turn anteriorly, continue along the gut, and enter the sinus venosus.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000401 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.460 - http://bgee.unil.ch/ @@ -328900,7 +145958,7 @@ The modern definition of neurosecretion has evolved to include the release of an vena vitellina - Wikipedia:Vitelline_veins + @@ -328914,7 +145972,7 @@ The modern definition of neurosecretion has evolved to include the release of an vitelline veins XAO:0004147 - + @@ -328997,7 +146055,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -329008,17 +146066,17 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/The-neural-crest + In the early gastrula of vertebrates, factors from the organizer (e.g. noggin, chordin, and follistatin in Xenopus) antagonize the epidermalizing factor bone morphogenetic protein 4 (BMP4), thus dividing the epiblast into neuroectoderm. In Drosophila, decapentaplegic, the homologue of BMP4, interacts similarly with the protein short gastrulation, the homologue of chordin. Thus, a comparable molecular mechanism for distinguishing non-neural ectoderm from neural ectoderm was probably present in the common ancestor of all bilaterally symmetrical animals.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001372 - VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) - http://bgee.unil.ch/ + VHOG + + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) @@ -329030,19 +146088,19 @@ The modern definition of neurosecretion has evolved to include the release of an epidermal ectoderm - https://github.com/obophenotype/uberon/wiki/The-neural-crest + epithelial ectoderm - https://github.com/obophenotype/uberon/wiki/The-neural-crest + surface ectoderm - https://github.com/obophenotype/uberon/wiki/The-neural-crest + @@ -329077,15 +146135,14 @@ The modern definition of neurosecretion has evolved to include the release of an Multi-tissue structure that arises from the heart rudiment and will become the heart tube. - BTO:0006179 + + EHDAA2:0001512 EHDAA:424 EHDAA:436 EMAPA:16215 FMA:321916 - SCTID:361522004 TAO:0000149 - Wikipedia:Primitive_heart_tube ZFA:0000149 primitive heart tube early primitive heart tube @@ -329103,7 +146160,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -329111,12 +146168,6 @@ The modern definition of neurosecretion has evolved to include the release of an Multi-tissue structure that arises from the heart rudiment and will become the heart tube. ZFA:0000149 - - - - BTO:0006179 - https://orcid.org/0000-0003-4423-4370 - @@ -329165,7 +146216,7 @@ The modern definition of neurosecretion has evolved to include the release of an A neural tube lateral wall that is part of a rhombomere. - OBOL:automatic + OBOL:automatic @@ -329208,13 +146259,13 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA - EHDAA2 + EHDAA2 @@ -329225,7 +146276,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -329237,11 +146288,11 @@ The modern definition of neurosecretion has evolved to include the release of an We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000269 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 - http://bgee.unil.ch/ @@ -329250,6 +146301,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -329288,7 +146340,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Obol + Obol @@ -329299,7 +146351,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -329311,16 +146363,16 @@ The modern definition of neurosecretion has evolved to include the release of an Immature reproductive tissue that has not undergone final maturation into either testis or ovary.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001262 - TAO - ZFIN:curator + TAO + ZFIN:curator future gonad - http://orcid.org/0000-0002-6601-2165 + @@ -329332,7 +146384,7 @@ The modern definition of neurosecretion has evolved to include the release of an primitive gonad - http://orcid.org/0000-0002-6601-2165 + @@ -329344,7 +146396,7 @@ The modern definition of neurosecretion has evolved to include the release of an immature gonad - http://orcid.org/0000-0002-6601-2165 + @@ -329400,7 +146452,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -329411,31 +146463,31 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Somite located in the head region, caudal to the otic vesicle. - PMID:11830559 + They provide the epaxial and hypaxial muscles of the neck, the pharyngeal and laryngeal muscles that develop in the caudal branchial arches and the musculature of the tongue. Despite their localisation in the head, myogenic precursors from occipital somites essentially follow the trunk programmes (E. H. Walters and S. D., unpublished). during evolution, have been secondarily incorporated into the head (Gans and Northcutt, 1983) - PMID:11830559 + EHDAA2 has both 'head somite' and 'head somite group', with part_of and develops_from for latter - EHDAA2 + EHDAA2 occipital somite - PMID:11830559 + XAO:0000313 @@ -329451,6 +146503,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -329486,7 +146539,7 @@ The modern definition of neurosecretion has evolved to include the release of an - XAO + XAO @@ -329497,7 +146550,7 @@ The modern definition of neurosecretion has evolved to include the release of an - XAO + XAO @@ -329560,7 +146613,7 @@ The modern definition of neurosecretion has evolved to include the release of an A somite that is part of a trunk. - OBOL:automatic + OBOL:automatic @@ -329583,6 +146636,8 @@ The modern definition of neurosecretion has evolved to include the release of an The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum. The dorsal sheet of the primitive mesentery that encloses the stomach. The greater omentum develops from the dorsal mesogastrium. [TFD][VHOG] + + EHDAA2:0000416 EHDAA:3001 EMAPA:17025 @@ -329590,7 +146645,6 @@ The modern definition of neurosecretion has evolved to include the release of an NCIT:C34142 UMLS:C1512038 VHOG:0000352 - Wikipedia:Dorsal_mesentery uberon dorsal mesentery UBERON:0005602 @@ -329600,7 +146654,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -329611,7 +146665,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -329622,23 +146676,23 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum. - Wikipedia:Dorsal_mesentery + The dorsal sheet of the primitive mesentery that encloses the stomach. The greater omentum develops from the dorsal mesogastrium. [TFD][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000352 - VHOG - http://bgee.unil.ch/ - http://medical-dictionary.thefreedictionary.com/mesogastrium + VHOG + + @@ -329650,7 +146704,7 @@ The modern definition of neurosecretion has evolved to include the release of an dorsal mesentery - Wikipedia:Dorsal_mesentery + @@ -329689,7 +146743,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -329700,7 +146754,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -329730,11 +146784,11 @@ The modern definition of neurosecretion has evolved to include the release of an A study of embryos shows that in all vertebrates six arterial arches link the ventral aorta with a pair of lateral dorsal aortae on each side of the body. The latter unite posteriorly to form a single median dorsal aorta wich takes blood to the body.[well established][VHOG] Contributes to the arch of aorta in humans + EHDAA2:0000936 EHDAA:404 EMAPA:16205 MA:0000478 - SCTID:361403005 VHOG:0000484 uberon UBERON:0005613 @@ -329744,17 +146798,17 @@ The modern definition of neurosecretion has evolved to include the release of an A study of embryos shows that in all vertebrates six arterial arches link the ventral aorta with a pair of lateral dorsal aortae on each side of the body. The latter unite posteriorly to form a single median dorsal aorta wich takes blood to the body.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000484 - VHOG + VHOG + ISBN:978-0174480198 Roberts MBV, Biology: a functional approach (1986) p.572 - http://bgee.unil.ch/ Contributes to the arch of aorta in humans - http://emedicine.medscape.com/article/899609-overview + @@ -329805,6 +146859,8 @@ The modern definition of neurosecretion has evolved to include the release of an A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex. Cells of the subcapsular epithelium (or anterior lens cells) are mitotically active. In adult individuals they only cover the anterior 'hemisphere' of the lens. As they divide, cells gradually move towards the equator of the lens where they tranform into lens fibres. The apical part of the gradually elongating cell extends between the subcapsular epithelium and adjacent lens fibres towards the anterior pole of the lens. The basal part extends towards the posterior pole. The nucleus remains close to the equatorial plane of the lens - http://www.lab.anhb.uwa.edu.au/mb140/corepages/eye/eye.htm lens epithelium + + EHDAA2:0000984 EHDAA:9059 EMAPA:17304 @@ -329813,7 +146869,6 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0001302 NCIT:C33641 RETIRED_EHDAA2:0000976 - SCTID:362521008 UMLS:C1182652 VHOG:0001425 lens subcapsular epithelium @@ -329839,7 +146894,7 @@ The modern definition of neurosecretion has evolved to include the release of an A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex. - http://orcid.org/0000-0002-6601-2165 + @@ -329851,7 +146906,7 @@ The modern definition of neurosecretion has evolved to include the release of an lens subcapsular epithelium - http://www.lab.anhb.uwa.edu.au/mb140/corepages/eye/eye.htm + @@ -329903,6 +146958,9 @@ The modern definition of neurosecretion has evolved to include the release of an Arteries which arise from the abdominal aorta and distribute to most of the intestines. includes posterior and anterior mesenteric arteries, which branch from the dorsal aorta (see Kardong), and superior and inferior mesenteric arteries + + + BTO:0000779 EHDAA2:0001123 EHDAA:4343 @@ -329910,10 +146968,8 @@ The modern definition of neurosecretion has evolved to include the release of an MA:0002003 MESH:D008638 NCIT:C52975 - SCTID:281084003 UMLS:C0025465 VHOG:0001117 - Wikipedia:Mesenteric_artery XAO:0000370 uberon UBERON:0005616 @@ -329928,14 +146984,14 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia Arteries which arise from the abdominal aorta and distribute to most of the intestines. + MESH:A07.231.114.565 - Wikipedia:Mesenteric_artery @@ -329975,6 +147031,9 @@ The modern definition of neurosecretion has evolved to include the release of an A vein that returns blood from the intestines. In humans the inferior mesenteric vein empties into the splenic vein, the superior mesenteric vein joins the splenic vein to form the portal vein + + + BTO:0002781 EHDAA:4442 EMAPA:17348 @@ -329982,9 +147041,7 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D008642 NCIT:C53055 RETIRED_EHDAA2:0001125 - SCTID:304045008 UMLS:C0025473 - Wikipedia:Mesenteric_vein uberon intestinal vein UBERON:0005617 @@ -329994,8 +147051,8 @@ The modern definition of neurosecretion has evolved to include the release of an A vein that returns blood from the intestines. + MESH:A07.231.908.670.385 - Wikipedia:Mesenteric_vein @@ -330007,7 +147064,7 @@ The modern definition of neurosecretion has evolved to include the release of an intestinal vein - http://orcid.org/0000-0002-6601-2165 + @@ -330025,11 +147082,11 @@ The modern definition of neurosecretion has evolved to include the release of an A study of embryos shows that in all vertebrates six arterial arches link the ventral aorta with a pair of lateral dorsal aortae on each side of the body. The latter unite posteriorly to form a single median dorsal aorta wich takes blood to the body.[well established][VHOG] Normally regresses in humans + EHDAA2:0001720 EHDAA:406 EMAPA:16206 MA:0000479 - SCTID:361404004 VHOG:0000485 uberon UBERON:0005622 @@ -330039,17 +147096,17 @@ The modern definition of neurosecretion has evolved to include the release of an A study of embryos shows that in all vertebrates six arterial arches link the ventral aorta with a pair of lateral dorsal aortae on each side of the body. The latter unite posteriorly to form a single median dorsal aorta wich takes blood to the body.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000485 - VHOG + VHOG + ISBN:978-0174480198 Roberts MBV, Biology: a functional approach (1986) p.572 - http://bgee.unil.ch/ Normally regresses in humans - http://emedicine.medscape.com/article/899609-overview + @@ -330058,6 +147115,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -330073,10 +147131,10 @@ The modern definition of neurosecretion has evolved to include the release of an Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo. stuctures homologous to the four extraembryonic membranes appear in mammals [ISBN:0073040584 (Vertebrates, Kardong)] EHDAA2 is a mereological sum. + EHDAA2:0004714 FMA:305915 MESH:D005321 - SCTID:362840007 uberon UBERON:0005631 extraembryonic membrane @@ -330086,13 +147144,13 @@ The modern definition of neurosecretion has evolved to include the release of an Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo. - ISBN:0073040584 + ISBN:0073040584 EHDAA2 is a mereological sum. - EHDAA2 + EHDAA2 @@ -330130,7 +147188,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a pylorus. - OBOL:automatic + OBOL:automatic @@ -330166,7 +147224,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a anterior chamber of eyeball. - OBOL:automatic + OBOL:automatic @@ -330204,7 +147262,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a lens vesicle. - OBOL:automatic + OBOL:automatic @@ -330247,17 +147305,17 @@ The modern definition of neurosecretion has evolved to include the release of an An ectoderm that is part of a pharyngeal arch 4. - OBOL:automatic + OBOL:automatic In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001095 - VHOG + VHOG + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) - http://bgee.unil.ch/ @@ -330306,17 +147364,17 @@ The modern definition of neurosecretion has evolved to include the release of an An endoderm that is part of a pharyngeal arch 4. - OBOL:automatic + OBOL:automatic In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001092 - VHOG + VHOG + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) - http://bgee.unil.ch/ @@ -330351,11 +147409,11 @@ The modern definition of neurosecretion has evolved to include the release of an A mesothelium that is part of a peritoneal cavity. we believe that this corresponds to EMAPA:16139 based on synonyms and parenthood peritoneum + BTO:0003156 EHDAA2:0001447 EMAPA:16139 FMA:18147 - SCTID:34073007 mesothelium of peritoneal component mesothelium of peritoneum peritoneal mesothelium @@ -330368,13 +147426,13 @@ The modern definition of neurosecretion has evolved to include the release of an A mesothelium that is part of a peritoneal cavity. - OBOL:automatic + OBOL:automatic we believe that this corresponds to EMAPA:16139 based on synonyms and parenthood - EMAPA + EMAPA @@ -330400,6 +147458,11 @@ The modern definition of neurosecretion has evolved to include the release of an peritoneal mesothelium BTO:0003156 + + + + + peritoneal mesothelium EMAPA:16139 @@ -330444,7 +147507,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of a right lung. - OBOL:automatic + OBOL:automatic @@ -330482,7 +147545,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of a left lung. - OBOL:automatic + OBOL:automatic @@ -330509,11 +147572,11 @@ The modern definition of neurosecretion has evolved to include the release of an A dorsal mesentery that is part of a midgut. + EMAPA:16722 EMAPA:17040 EMAPA:18671 RETIRED_EHDAA2:0001187 - SCTID:361434009 uberon UBERON:0005685 midgut dorsal mesentery @@ -330522,7 +147585,7 @@ The modern definition of neurosecretion has evolved to include the release of an A dorsal mesentery that is part of a midgut. - OBOL:automatic + OBOL:automatic @@ -330542,6 +147605,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -330570,17 +147634,17 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical cavity that is part of a lens vesicle. - OBOL:automatic + OBOL:automatic (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000531 - VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 - http://bgee.unil.ch/ + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 @@ -330636,17 +147700,17 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a pharyngeal arch 4. - OBOL:automatic + OBOL:automatic In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001052 - VHOG + VHOG + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) - http://bgee.unil.ch/ @@ -330692,7 +147756,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a optic eminence. - OBOL:automatic + OBOL:automatic @@ -330735,7 +147799,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mesentery of duodenum that is part of a foregut. - OBOL:automatic + OBOL:automatic @@ -330779,7 +147843,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mesentery of duodenum that is part of a midgut. - OBOL:automatic + OBOL:automatic @@ -330800,6 +147864,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -330819,7 +147884,7 @@ The modern definition of neurosecretion has evolved to include the release of an A venous system that is part of a hindbrain. - OBOL:automatic + OBOL:automatic @@ -330830,36 +147895,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - BILA:0000139 - uberon - UBERON:0005726 - - chemosensory system - - - - @@ -330884,7 +147919,6 @@ The modern definition of neurosecretion has evolved to include the release of an - . EHDAA2:0000474 EMAPA:31862 EMAPA:31863 @@ -330900,7 +147934,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -330911,13 +147945,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 - - - - - . - http://www.ana.ed.ac.uk/database/humat/notes/extraemb/mesoder.htm + EHDAA2 @@ -330958,16 +147986,16 @@ The modern definition of neurosecretion has evolved to include the release of an A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme. - OBOL:automatic + OBOL:automatic Embryonic region that develops into the pectoral fin bud.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001453 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -331015,16 +148043,16 @@ The modern definition of neurosecretion has evolved to include the release of an A limb/fin field that has the potential to develop into a pelvic appendage bud mesenchyme. - OBOL:automatic + OBOL:automatic Embryonic region that develops into the pelvic fin bud.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001454 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -331099,7 +148127,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -331117,12 +148144,13 @@ The modern definition of neurosecretion has evolved to include the release of an The outermost layer of a blood vessel, composed mainly of fibrous tissue. TODO - note terminological problems. WP says tunica external layer of blood vessel. FMA says tunica externa = adventitia, and is FMA adventitia covers other kinds of vessels. Here we opt for a lengthier name that attempts to disambiguate. There is no precise FMA equivalent, as FMA has tunica externa of arteries, veins, genital ducts etc as siblings The outermost layer of a blood vessel, surrounding the tunica media. It is mainly composed of collagen. The collagen serves to anchor the blood vessel to nearby organs, giving it stability[Wikipedia:Tunica_externa_(vessels)]. + + + BTO:0002010 EMAPA:36299 NCIT:C33818 - SCTID:61066005 UMLS:C0225342 - Wikipedia:Tunica_externa_(vessels) adventitia externa tunica adventitia tunica adventitia of vessel @@ -331132,26 +148160,26 @@ The modern definition of neurosecretion has evolved to include the release of an tunica externa vasorum UBERON:0005734 tunica adventitia of blood vessel - https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg + https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg - cjm + cjm The outermost layer of a blood vessel, composed mainly of fibrous tissue. - ISBN:0073040584 - Wikipedia:Tunica_externa_(vessels) + + ISBN:0073040584 The outermost layer of a blood vessel, surrounding the tunica media. It is mainly composed of collagen. The collagen serves to anchor the blood vessel to nearby organs, giving it stability[Wikipedia:Tunica_externa_(vessels)]. - Wikipedia:Tunica_externa_(vessels) + @@ -331163,38 +148191,38 @@ The modern definition of neurosecretion has evolved to include the release of an adventitia externa - Wikipedia:Tunica_externa_(vessels) + tunica adventitia - Wikipedia:Tunica_externa_(vessels) + tunica adventitia of vessel - Wikipedia:Tunica_externa_(vessels) + external coat - Wikipedia:Tunica_externa_(vessels) + tunica adventitia vasorum - Wikipedia:Tunica_externa_(vessels) + tunica externa vasorum - Wikipedia:Tunica_externa_(vessels) + @@ -331229,10 +148257,10 @@ The modern definition of neurosecretion has evolved to include the release of an A tunica intima that is part of a artery. + EMAPA:36293 EV:0100028 FMA:14272 - SCTID:40022005 galen:IntimaOfArtery arterial intima tunica interna (intima)(arteriae) @@ -331244,7 +148272,7 @@ The modern definition of neurosecretion has evolved to include the release of an A tunica intima that is part of a artery. - OBOL:automatic + OBOL:automatic @@ -331279,11 +148307,11 @@ The modern definition of neurosecretion has evolved to include the release of an An outermost connective tissue covering of an organ, vessel, or other structure[WP]. + + BTO:0002010 FMA:45635 MESH:D063194 - SCTID:30180000 - Wikipedia:Adventitia tunica advetitia tunica externa uberon @@ -331291,19 +148319,19 @@ The modern definition of neurosecretion has evolved to include the release of an adventitia - http://upload.wikimedia.org/wikipedia/commons/e/e8/Illu_esophageal_layers.jpg + http://upload.wikimedia.org/wikipedia/commons/e/e8/Illu_esophageal_layers.jpg An outermost connective tissue covering of an organ, vessel, or other structure[WP]. - Wikipedia:Adventitia + tunica advetitia - Wikipedia:Adventitia + @@ -331346,19 +148374,19 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0005744 bone foramen - http://upload.wikimedia.org/wikipedia/commons/8/81/Gray193.png + http://upload.wikimedia.org/wikipedia/commons/8/81/Gray193.png Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves. - TAO:curator + TAO:curator in FMA and ZFA this is a conduit space, not a conduit. Note there may be some additional disambiguation required: foramen is used loosely in the sense of any opening (e.g. foramen primum). FMA appears to use cranial conduit (undefined) in the sense of any foramen of the skull (includes mental foramen, which is not in the cranium proper). - FMA + FMA @@ -331397,20 +148425,16 @@ The modern definition of neurosecretion has evolved to include the release of an An acellular anatomical structure that is the bounding layer of a anatomical structure. - - - FMA:63871 uberon UBERON:0005764 - acellular membrane An acellular anatomical structure that is the bounding layer of a anatomical structure. - OBOL:automatic + OBOL:automatic @@ -331418,7 +148442,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -331453,13 +148476,14 @@ The modern definition of neurosecretion has evolved to include the release of an An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina. this class represents a continuous sheet of basement membrane which can underlie multiple epithelial cells over large regions. In contrast, the GO class 'basal membrane' represents a portion of substance on the scale of a single cell. + + + AAO:0010596 FMA:63872 GAID:915 NCIT:C13191 - SCTID:68989006 UMLS:C0004799 - Wikipedia:Basement_membrane basement membrane of connective tissue membrana basalis uberon @@ -331471,20 +148495,20 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina. - Wikipedia:Basement_membrane - http://orcid.org/0000-0002-6601-2165 + + - http://palaeos.com/metazoa/porifera/homoscleromorpha.html + @@ -331502,7 +148526,7 @@ The modern definition of neurosecretion has evolved to include the release of an membrana basalis - Wikipedia:Basement_membrane + @@ -331526,9 +148550,10 @@ The modern definition of neurosecretion has evolved to include the release of an Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle. + + FMA:13087 NCIT:C34027 - SCTID:119203005 UMLS:C0506947 aortic section uberon @@ -331594,14 +148619,14 @@ The modern definition of neurosecretion has evolved to include the release of an The artery in vertebrate embryos that transports blood from the aortic arches to the trunk and limbs. In adult fish it is a major artery that carries oxygenated blood from the efferent branchial arteries to branches that supply the body organ. In adult tetrapods it arises from the systemic arch relationship loss: part_of axial vasculature (TAO:0001073)[TAO] When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG] + + AAO:0011029 BTO:0004673 EHDAA:402 EMAPA:18606 - SCTID:338637006 TAO:0000014 VHOG:0000264 - Wikipedia:Dorsal_aorta XAO:0000051 ZFA:0000014 DA @@ -331615,29 +148640,29 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0005805 dorsal aorta - http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray459.png + http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray459.png The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. + GO:0035907 - https://sourceforge.net/p/geneontology/ontology-requests/8525/ Each primitive aorta receives anteriorly a vein 'the vitelline vein' from the yolk-sac, and is prolonged backward on the lateral aspect of the notochord under the name of the dorsal aorta. The dorsal aortae give branches to the yolk-sac, and are continued backward through the body-stalk as the umbilical arteries to the villi of the chorion. The two dorsal aortae combine to become the descending aorta in later development[WP]. - Wikipedia:Dorsal_aorta + Principal unpaired, median artery of the trunk, leading from the paired roots (radices) of the dorsal aorta to the caudal artery. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000014 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -331649,19 +148674,19 @@ The modern definition of neurosecretion has evolved to include the release of an relationship loss: part_of axial vasculature (TAO:0001073)[TAO] - 2012-08-14 + 2012-08-14 TAO:0000014 - TAO + TAO When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000264 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 - http://bgee.unil.ch/ @@ -331680,7 +148705,7 @@ The modern definition of neurosecretion has evolved to include the release of an aortae dorsales - Wikipedia:Dorsal_aorta + @@ -331693,8 +148718,8 @@ The modern definition of neurosecretion has evolved to include the release of an dorsal aortae - Wikipedia:Dorsal_aorta - + + @@ -331706,8 +148731,8 @@ The modern definition of neurosecretion has evolved to include the release of an dorsal aortæ - Wikipedia:Dorsal_aorta - + + @@ -331723,12 +148748,13 @@ The modern definition of neurosecretion has evolved to include the release of an In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP]. + + + FMA:45628 MESH:D011168 NCIT:C33344 - SCTID:362063001 UMLS:C0226727 - Wikipedia:Portal_venous_system portal venous system uberon UBERON:0005806 @@ -331738,7 +148764,7 @@ The modern definition of neurosecretion has evolved to include the release of an In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP]. - Wikipedia:Portal_venous_system + @@ -331766,10 +148792,10 @@ The modern definition of neurosecretion has evolved to include the release of an This is currently used loosely to refer to cervical, lumbar, etc as well as the metamerically repeated segments, which may correspond more closely with the ZFA neuromere term + BIRNLEX:2665 FMA:62420 MA:0003080 - SCTID:278748001 axial part of spinal cord axial regional part of spinal cord segment of spinal cord @@ -331801,7 +148827,7 @@ The modern definition of neurosecretion has evolved to include the release of an spinal neuromeres TAO:0001332 - + @@ -331828,9 +148854,9 @@ The modern definition of neurosecretion has evolved to include the release of an A spinal cord segment that adjacent_to a caudal region. + FMA:256635 MA:0003084 - SCTID:278753006 neuronames:1656 coccygeal segment of spinal cord coccygeal segments of spinal cord [1-3] @@ -331846,7 +148872,7 @@ The modern definition of neurosecretion has evolved to include the release of an A spinal cord segment that adjacent_to a caudal region. - OBOL:automatic + OBOL:automatic @@ -331865,7 +148891,7 @@ The modern definition of neurosecretion has evolved to include the release of an pars coccygea medullae spinalis FMA:256635 - FMA:TA + FMA:TA @@ -331873,7 +148899,7 @@ The modern definition of neurosecretion has evolved to include the release of an segmenta coccygea medullae spinalis [1-3] FMA:256635 - FMA:TA + FMA:TA @@ -331910,13 +148936,13 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO - cjm + cjm @@ -331978,7 +149004,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -331989,7 +149015,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -332075,7 +149101,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -332120,7 +149146,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -332131,7 +149157,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -332144,7 +149170,7 @@ The modern definition of neurosecretion has evolved to include the release of an A closely packed aggregation of mesenchymal cells just prior to their differentiation into embryonic cartilage. - http://dictionary.reference.com/browse/precartilage + @@ -332152,6 +149178,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -332167,13 +149194,14 @@ The modern definition of neurosecretion has evolved to include the release of an The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip. check develops_from + + EHDAA2:0001061 EHDAA:5871 EMAPA:17355 FMA:293051 NCIT:C34204 UMLS:C1512982 - Wikipedia:Mandibular_prominence uberon mandibular process mandibular swelling @@ -332186,7 +149214,7 @@ The modern definition of neurosecretion has evolved to include the release of an The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0010939 @@ -332199,19 +149227,19 @@ The modern definition of neurosecretion has evolved to include the release of an mandibular process - Wikipedia:Mandibular_prominence + mandibular swelling - https://orcid.org/0000-0002-6601-2165 + prominentia mandibularis - Wikipedia:Mandibular_prominence + @@ -332220,6 +149248,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -332234,14 +149263,15 @@ The modern definition of neurosecretion has evolved to include the release of an The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw. + + + EHDAA2:0001070 EHDAA:5877 EMAPA:17359 FMA:293049 NCIT:C34206 - SCTID:346355001 UMLS:C1513037 - Wikipedia:Maxillary_prominence embryonic maxillary process maxillary process maxillary process of embryo @@ -332250,13 +149280,13 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0005868 maxillary prominence - http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png + http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw. - ISBN:0-683-40008-8 + ISBN:0-683-40008-8 MP:0010940 @@ -332275,7 +149305,7 @@ The modern definition of neurosecretion has evolved to include the release of an prominentia maxilaris - Wikipedia:Maxillary_prominence + @@ -332295,10 +149325,10 @@ The modern definition of neurosecretion has evolved to include the release of an TODO - check An anatomical cluster that is located in the posterior region of the neurocranium and forms the margin of the foramen margin and occipital condyles.[AAO] Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occiptal condyle.[TAO] + AAO:0010199 BTO:0004675 FMA:49187 - SCTID:362618001 TAO:0001414 XAO:0003173 ZFA:0001414 @@ -332322,18 +149352,18 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical cluster that is located in the posterior region of the neurocranium and forms the margin of the foramen margin and occipital condyles.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010199 - AAO - AAO:EJS + AAO + AAO:EJS Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occiptal condyle.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001414 - TAO + TAO TAO:MAH @@ -332366,8 +149396,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -332382,8 +149412,10 @@ The modern definition of neurosecretion has evolved to include the release of an Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA]. + + EMAPA:16060 FMA:9689 - SCTID:362890006 + MA:0000005 uberon UBERON:0005906 See notes for serous membrane @@ -332393,8 +149425,8 @@ The modern definition of neurosecretion has evolved to include the release of an Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA]. + FMA:9689 - https://github.com/obophenotype/uberon/issues/86 @@ -332441,6 +149473,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -332464,7 +149497,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -332478,6 +149511,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -332504,47 +149538,46 @@ The modern definition of neurosecretion has evolved to include the release of an Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]. - Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO] + + + AAO:0000963 EMAPA:17214 EMAPA:18043 MA:0000308 NCIT:C32172 - SCTID:361725000 UMLS:C0222645 VSAO:0000056 - Wikipedia:Axial_skeleton XAO:0004011 uberon skeleton axiale UBERON:0005944 - axial skeleton plus cranial skeleton http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton - http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg + http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]. + + + FMA:71221 VSAO:0000056 - Wikipedia:Axial_skeleton - https://github.com/obophenotype/uberon/issues/44 - https://github.com/obophenotype/uberon/wiki/The-axial-skeleton Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000056 - VSAO - PSPUB:0000170 + VSAO + PSPUB:0000170 @@ -332556,7 +149589,7 @@ The modern definition of neurosecretion has evolved to include the release of an skeleton axiale - Wikipedia:Axial_skeleton + @@ -332594,7 +149627,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -332605,7 +149638,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -332616,7 +149649,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -332636,7 +149669,7 @@ The modern definition of neurosecretion has evolved to include the release of an neurocranial trabeculae ZFA:0001321 - + @@ -332679,7 +149712,7 @@ The modern definition of neurosecretion has evolved to include the release of an An outflow tract that is part of a cardiac atrium. - OBOL:automatic + OBOL:automatic @@ -332725,10 +149758,11 @@ The modern definition of neurosecretion has evolved to include the release of an Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk. infundibulum + + EMAPA:37926 FMA:7216 NCIT:C61368 - SCTID:244379003 UMLS:C1881209 RVOT conus arteriosus (infundibulum) @@ -332754,7 +149788,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:17276708 + @@ -332766,13 +149800,13 @@ The modern definition of neurosecretion has evolved to include the release of an infundibulum - Wikipedia:Conus_arteriosus + EMAPA:37926 - MA:th + MA:th @@ -332785,7 +149819,7 @@ The modern definition of neurosecretion has evolved to include the release of an RVOT MP:0010428 - + @@ -332798,6 +149832,11 @@ The modern definition of neurosecretion has evolved to include the release of an infundibulum of right ventricle FMA:7216 + + + + + infundibulum of right ventricle MP:0010428 @@ -332873,10 +149912,10 @@ The modern definition of neurosecretion has evolved to include the release of an Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta. + + EMAPA:37925 FMA:9473 - SCTID:264070001 - Wikipedia:Aortic_vestibule LVOT Sibson vestibule aortic vestibule @@ -332900,14 +149939,14 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37925 - MA:th + MA:th LVOT MP:0010429 - + @@ -332920,6 +149959,11 @@ The modern definition of neurosecretion has evolved to include the release of an aortic vestibule FMA:9473 + + + + + aortic vestibule MP:0010429 @@ -332951,7 +149995,7 @@ The modern definition of neurosecretion has evolved to include the release of an vestibulum aortae FMA:9473 - FMA:TA + FMA:TA @@ -332991,7 +150035,7 @@ The modern definition of neurosecretion has evolved to include the release of an Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA]. FMA:9550 - FMA:FMA + FMA:FMA @@ -333041,7 +150085,7 @@ The modern definition of neurosecretion has evolved to include the release of an An outflow tract of atrium that is part of a left atrium. - OBOL:automatic + OBOL:automatic @@ -333058,71 +150102,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium. - EMAPA:37837 - FMA:9236 - SCTID:277693004 - Wikipedia:Crista_terminalis - crista terminalis atrii dextri - crista terminalis cordis - crista terminalis of right atrium - uberon - UBERON:0005979 - - crista terminalis - - - - - The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium. - MP:0010495 - - - - - EMAPA:37837 - MA:th - - - - - crista terminalis atrii dextri - FMA:9236 - FMA:TA - - - - - - crista terminalis cordis - FMA:9236 - - - - - crista terminalis of right atrium - FMA:9236 - - - - @@ -333197,8 +150176,8 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation. TODO - change relation from part_of + MESH:D003331 - Wikipedia:Coronary_circulation uberon UBERON:0005985 @@ -333269,7 +150248,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -333282,14 +150261,14 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37432 - MA:th + MA:th atrium myocardial trabeculae MP:0010581 - + @@ -333339,10 +150318,10 @@ The modern definition of neurosecretion has evolved to include the release of an The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve. + + EMAPA:37431 FMA:7136 - SCTID:280151006 - Wikipedia:Atrioventricular_septum membranous atrioventricular septum uberon UBERON:0005989 @@ -333358,8 +150337,8 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:15797462 - Wikipedia + + Wikipedia @@ -333371,7 +150350,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37431 - MA:th + MA:th @@ -333396,8 +150375,15 @@ The modern definition of neurosecretion has evolved to include the release of an - + + + + + + + + @@ -333406,27 +150392,27 @@ The modern definition of neurosecretion has evolved to include the release of an - + The paired arteries that carry blood to the yolk sac from the dorsal aorta. + EHDAA2:0002208 EMAPA:16207 - Wikipedia:Vitelline_arteries uberon UBERON:0006002 Development notes:; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult[MP:0010664] vitelline artery - http://upload.wikimedia.org/wikipedia/commons/5/55/Gray31.png + http://upload.wikimedia.org/wikipedia/commons/5/55/Gray31.png - + @@ -333436,8 +150422,8 @@ The modern definition of neurosecretion has evolved to include the release of an The paired arteries that carry blood to the yolk sac from the dorsal aorta. + MP:0010664 - Wikipedia:Vitelline_arteries @@ -333455,8 +150441,8 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers. add subclasses based on resolution of CARO tracker item. Also check: adnexal gland. Note that MP implicitly includes hypodermis. the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails[MP:0010678] + EMAPA:37883 - Wikipedia:Skin_appendage body hair or bristle uberon adnexae cutis @@ -333471,8 +150457,8 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers. - http://code.google.com/p/caro2/issues/detail?id=5 - http://orcid.org/0000-0002-6601-2165 + + @@ -333484,7 +150470,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37883 - MA:th + MA:th @@ -333496,20 +150482,20 @@ The modern definition of neurosecretion has evolved to include the release of an adnexae cutis - Wikipedia:Skin_appendage + skin adnexa - Wikipedia:Skin_appendage + skin appendage - Wikipedia:Skin_appendage + @@ -333584,13 +150570,13 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a post-anal tail. - OBOL:automatic + OBOL:automatic MA has distinct classes for 'tail bone', 'caudal vertebra' and 'coccygeal vertebra' but these may all be equivalent. This class may be obsoleted in future. - MA + MA @@ -333602,7 +150588,7 @@ The modern definition of neurosecretion has evolved to include the release of an tail vertebra - http://orcid.org/0000-0002-6601-2165 + @@ -333610,6 +150596,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -333645,25 +150632,25 @@ The modern definition of neurosecretion has evolved to include the release of an Subdivision of an organism along anterior-posterior axis that is the posteriormost region, extending past the anus (or cloaca, if present), consisting of a tail in some fully formed chordates (or a tail bud in embryos). In animals that have a sacral region, this is the region immediately posterior to this. - http://orcid.org/0000-0002-6601-2165 + We follow XAO is distinguishing the tail region from the tail; the tail bud is part of the tail region; the tail starts after the tail bud - XAO + XAO post-anal caudal region - http://orcid.org/0000-0002-6601-2165 + post-anal tail region - http://orcid.org/0000-0002-6601-2165 + @@ -333715,6 +150702,8 @@ The modern definition of neurosecretion has evolved to include the release of an That portion of the spine comprising the cervical vertebrae. The neck area of the spine. Anterior region of the vertebral column consisting of one to 19 or 20 vertebrae.[AAO] + + AAO:0000092 BTO:0004148 EHDAA2:0000238 @@ -333723,7 +150712,6 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:24138 MA:0003154 NCIT:C69313 - SCTID:260488005 UMLS:C0728985 axial skeleton cervical region cervical skeleton @@ -333746,21 +150734,21 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA That portion of the spine comprising the cervical vertebrae. The neck area of the spine. - http://medical-dictionary.thefreedictionary.com/ + Anterior region of the vertebral column consisting of one to 19 or 20 vertebrae.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000092 - AAO + AAO AAO:Duellman_and_Trueb_1994 @@ -333843,6 +150831,8 @@ The modern definition of neurosecretion has evolved to include the release of an That part of the spine comprising the thoracic vertebrae. Region of the vertebral column between the atlas and the sacrum consisting of seven to 285 vertebrae.[AAO] + + AAO:0000612 BTO:0004150 EHDAA:5063 @@ -333850,7 +150840,6 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:9140 MA:0003155 NCIT:C69315 - SCTID:243931006 UMLS:C0581269 axial skeleton thoracic region columna vertebralis thoracicus @@ -333871,21 +150860,21 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA That part of the spine comprising the thoracic vertebrae. - http://medical-dictionary.thefreedictionary.com/ + Region of the vertebral column between the atlas and the sacrum consisting of seven to 285 vertebrae.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000612 - AAO + AAO AAO:Duellman_and_Trueb_1994 @@ -333980,16 +150969,16 @@ The modern definition of neurosecretion has evolved to include the release of an Region of the vertebral column posterior to the caudal-sacral region, that may consists of two or three to more than 100 vertebrae. These vertebrae exhibit a gradual reduction in the sizes of their transverse processes and zygapophyses, but these structures are never entirely absent. All caudal vertebrae bear haemal arches.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000082 - AAO + AAO AAO:Duellman_and_Trueb_1994 in AAO, this is posterior to the caudal-sacral region - AAO + AAO @@ -334007,7 +150996,7 @@ The modern definition of neurosecretion has evolved to include the release of an caudal vertebrae series - http://purl.bioontology.org/ontology/provisional/a047a2d5-418f-4d9c-ad21-ee0b7c29c29d + @@ -334045,6 +151034,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -334085,19 +151075,19 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A collection of all skeletal elements in some subdivision of the vertebral column. - https://orcid.org/0000-0002-6601-2165 + subdivision of vertebral skeleton - https://orcid.org/0000-0002-6601-2165 + @@ -334154,12 +151144,12 @@ The modern definition of neurosecretion has evolved to include the release of an The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions. UBERON:0005999 + CALOHA:TS-2409 EHDAA2:0000136 EHDAA:2592 EMAPA:16827 VHOG:0000502 - Wikipedia:Aorticopulmonary_septum aortico-pulmonary septum aorticopulmonary septum septum aorticopulmonale @@ -334170,7 +151160,7 @@ The modern definition of neurosecretion has evolved to include the release of an aortico-pulmonary spiral septum - http://upload.wikimedia.org/wikipedia/commons/b/b9/Gray470.png + http://upload.wikimedia.org/wikipedia/commons/b/b9/Gray470.png @@ -334181,7 +151171,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EMAPA + EMAPA @@ -334192,46 +151182,46 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:6844926 - Wikipedia + + Wikipedia The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions. + MP:0010650 - Wikipedia:Aorticopulmonary_septum aortico-pulmonary septum - Wikipedia:Aorticopulmonary_septum + aorticopulmonary septum - Wikipedia:Aorticopulmonary_septum + septum aorticopulmonale - Wikipedia:Aorticopulmonary_septum + aortic septum - Wikipedia:Aorticopulmonary_septum + spiral septum - Wikipedia:Aorticopulmonary_septum + @@ -334239,6 +151229,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -334277,13 +151268,13 @@ The modern definition of neurosecretion has evolved to include the release of an The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx. + + EHDAA2:0000189 EHDAA:536 EMAPA:16259 FMA:313607 - SCTID:361412007 VHOG:0000380 - Wikipedia:Buccopharyngeal_membrane uberon oral membrane oral plate @@ -334293,7 +151284,7 @@ The modern definition of neurosecretion has evolved to include the release of an buccopharyngeal membrane - http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png + http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png @@ -334304,7 +151295,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -334328,7 +151319,7 @@ The modern definition of neurosecretion has evolved to include the release of an oropharyngeal membrane - Wikipedia:Buccopharyngeal_membrane + @@ -334343,6 +151334,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -334376,6 +151368,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -334419,7 +151412,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -334430,7 +151423,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AAO + AAO @@ -334441,7 +151434,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -334464,6 +151457,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -334498,17 +151492,17 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical junctions that overlaps the foregut and midgut. - OBOL:automatic + OBOL:automatic Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000291 - VHOG + VHOG + ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11 - http://bgee.unil.ch/ @@ -334528,6 +151522,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -334603,7 +151598,7 @@ The modern definition of neurosecretion has evolved to include the release of an The embryonic precursor of the brain and the set of mature brain structures that derive from it (CUMBO) - http://neurolex.org/wiki/Cumbo_terms + @@ -334688,7 +151683,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -334701,25 +151696,25 @@ The modern definition of neurosecretion has evolved to include the release of an mesenchyme cranial part - Wikipedia + Wikipedia A tendon that has the potential to develop into a central tendon. - OBOL:automatic + OBOL:automatic cranial derivative of septum transversum - http://orcid.org/0000-0002-6601-2165 + cranial part of septum transversum - http://orcid.org/0000-0002-6601-2165 + @@ -334778,7 +151773,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -334867,7 +151862,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EMAPA + EMAPA @@ -334878,7 +151873,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -334908,6 +151903,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -334941,7 +151937,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical junctions that overlaps the mouth and foregut. - OBOL:automatic + OBOL:automatic @@ -334968,6 +151964,7 @@ The modern definition of neurosecretion has evolved to include the release of an The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. TODO - check ordering; awaiting confirmation from JB The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG] + EHDAA2:0001278 EHDAA:264 EMAPA:16101 @@ -334983,7 +151980,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -334994,7 +151991,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -335006,10 +152003,10 @@ The modern definition of neurosecretion has evolved to include the release of an The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001212 - VHOG - http://bgee.unil.ch/ + VHOG + @@ -335023,6 +152020,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -335037,6 +152035,7 @@ The modern definition of neurosecretion has evolved to include the release of an A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot. + EHDAA2:0001279 EHDAA:224 EMAPA:16102 @@ -335061,13 +152060,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot. - http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/05embryonicperiod.htm + @@ -335107,10 +152106,10 @@ The modern definition of neurosecretion has evolved to include the release of an Either of two openings transmitting nerves and blood vessels to or from the orbit. + EHDAA2:0001328 EHDAA:10648 EMAPA:18717 - SCTID:280546005 uberon UBERON:0006271 @@ -335125,13 +152124,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EMAPA + EMAPA Either of two openings transmitting nerves and blood vessels to or from the orbit. - http://www.merriam-webster.com/medical/orbital%20fissure + @@ -335188,11 +152187,11 @@ The modern definition of neurosecretion has evolved to include the release of an Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity. Each of the canal that links the peritoneal cavity and the caudal part of a pleural cavity. [ISBN:0124020607][VHOG] + EHDAA2:0001481 EHDAA:4128 EMAPA:17704 EMAPA:17707 - SCTID:361413002 VHOG:0001505 uberon pleuroperitoneal channel @@ -335204,7 +152203,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -335215,7 +152214,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -335228,10 +152227,10 @@ The modern definition of neurosecretion has evolved to include the release of an Each of the canal that links the peritoneal cavity and the caudal part of a pleural cavity. [ISBN:0124020607][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001505 - VHOG - http://bgee.unil.ch/ + VHOG + @@ -335273,13 +152272,13 @@ The modern definition of neurosecretion has evolved to include the release of an Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle. UBERON:0010226 embryonic ventricle + + EHDAA2:0001531 EMAPA:16350 FMA:71006 NCIT:C34160 - SCTID:361524003 TAO:0002231 - Wikipedia:Embryonic_ventricle ZFA:0001719 early heart ventricle embryonic heart ventricle @@ -335303,7 +152302,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -335314,7 +152313,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EMAPA + EMAPA @@ -335395,7 +152394,7 @@ The modern definition of neurosecretion has evolved to include the release of an - XAO + XAO @@ -335417,7 +152416,7 @@ The modern definition of neurosecretion has evolved to include the release of an - XAO + XAO @@ -335430,7 +152429,7 @@ The modern definition of neurosecretion has evolved to include the release of an check difference between splenic and spleen in EMAPA; note that in EHDAA2 the class 'spleen' refers to the mesenchyme - EMAPA + EMAPA @@ -335442,7 +152441,7 @@ The modern definition of neurosecretion has evolved to include the release of an splenic mesenchyme - https://orcid.org/0000-0002-6601-2165 + @@ -335513,7 +152512,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -335563,12 +152562,13 @@ The modern definition of neurosecretion has evolved to include the release of an A segment of the eyeball that is filled with refractive media. + + BTO:0002085 EMAPA:37529 FMA:58071 MA:0002459 NCIT:C32301 - SCTID:280540004 UMLS:C0459556 eye chamber eyeball chamber @@ -335581,13 +152581,13 @@ The modern definition of neurosecretion has evolved to include the release of an A segment of the eyeball that is filled with refractive media. - http://orcid.org/0000-0002-6601-2165 + EMAPA:37529 - MA:th + MA:th @@ -335620,6 +152620,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -335637,7 +152638,7 @@ The modern definition of neurosecretion has evolved to include the release of an Body substance in a liquid or semi-solid state in the eyeball which serves to refract light. - http://orcid.org/0000-0002-6601-2165 + @@ -335665,12 +152666,12 @@ The modern definition of neurosecretion has evolved to include the release of an Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not. fluid + BIRNLEX:20 EMAPA:37441 FMA:280556 GAID:266 MESH:D001826 - Wikipedia:Body_fluid galen:BodyFluid body fluid uberon @@ -335682,14 +152683,14 @@ The modern definition of neurosecretion has evolved to include the release of an Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not. + MESH:A12.207 - Wikipedia:Body_fluid EMAPA:37441 - MA:th + MA:th @@ -335733,7 +152734,7 @@ The modern definition of neurosecretion has evolved to include the release of an A nucleus of brain that is part of a brainstem. - OBOL:automatic + OBOL:automatic @@ -335767,6 +152768,7 @@ The modern definition of neurosecretion has evolved to include the release of an An artery that connects two larger arteries. + EMAPA:18598 MA:0001938 NCIT:C52851 @@ -335791,67 +152793,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - A lobe of lung that is part of a right lung. - 4 in mice, divided into 3 in human by two interlobal fissures - EMAPA:35155 - MA:0001791 - NCIT:C48944 - SCTID:272654004 - UMLS:C1285106 - lobe of right lung - lobe of the right lung - uberon - UBERON:0006518 - right lung lobe - - - - - A lobe of lung that is part of a right lung. - OBOL:automatic - - - - - 4 in mice, divided into 3 in human by two interlobal fissures - ISBN:0123813611 - - - - - UMLS:C1285106 - ncithesaurus:Lobe_of_the_Right_Lung - - - - - lobe of the right lung - ncithesaurus:Lobe_of_the_Right_Lung - - - - @@ -335886,7 +152827,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of organism substance that secreted_by a zone of skin. - OBOL:automatic + OBOL:automatic @@ -335931,7 +152872,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of organism substance that is secreted by a female reproductive gland. - UBERON:cjm + UBERON:cjm @@ -335964,6 +152905,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of organism substance that secreted_by a respiratory system. + EMAPA:36550 MA:0002533 NCIT:C13722 @@ -335978,7 +152920,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of organism substance that secreted_by a respiratory system. - OBOL:automatic + OBOL:automatic @@ -336019,7 +152961,7 @@ The modern definition of neurosecretion has evolved to include the release of an A tube that is part of a excretory system. - OBOL:automatic + OBOL:automatic @@ -336036,9 +152978,9 @@ The modern definition of neurosecretion has evolved to include the release of an The pharynx is the part of the digestive system immediately posterior to the mouth[GO]. currently this is an extremely generic class, encompassing both protostomes and deuterostomes. - 2023-04-20 branchial pharyngeal + FBbt:00005380 MAT:0000049 MESH:D010614 MIAA:0000049 @@ -336091,7 +153033,7 @@ The modern definition of neurosecretion has evolved to include the release of an Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA]. FMA:85030 - FMA:FMA + FMA:FMA @@ -336126,10 +153068,10 @@ The modern definition of neurosecretion has evolved to include the release of an A myocardium that is part of a left ventricle of a heart. Myocardium of ventricle which is continuous with the tunica media of aorta. + EMAPA:17339 FMA:9558 MA:0002983 - SCTID:362021000 left ventricular myocardium myocardium of left ventricle uberon @@ -336141,7 +153083,7 @@ The modern definition of neurosecretion has evolved to include the release of an A myocardium that is part of a left ventricle of a heart. - http://orcid.org/0000-0002-6601-2165 + @@ -336194,10 +153136,10 @@ The modern definition of neurosecretion has evolved to include the release of an A myocardium that is part of a right ventricle of a heart. Myocardium of ventricle which is continuous with the tunica media of the pulmonary trunk. + EMAPA:17342 FMA:9535 MA:0002984 - SCTID:362020004 myocardium of right ventricle right ventricular myocardium uberon @@ -336210,7 +153152,7 @@ The modern definition of neurosecretion has evolved to include the release of an A myocardium that is part of a right ventricle of a heart. - http://orcid.org/0000-0002-6601-2165 + @@ -336233,94 +153175,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - A trabecula carnea that is part of a heart right ventricle. - FMA:7270 - SCTID:192373001 - trabeculae carneae (ventriculus dexter) - uberon - UBERON:0006570 - trabecula carnea of right ventricle - - - - - A trabecula carnea that is part of a heart right ventricle. - OBOL:automatic - - - - - trabeculae carneae (ventriculus dexter) - FMA:7270 - - - - - - - - - - - - - - - - - - - - - - - - - - A trabecula carnea that is part of a heart left ventricle. - FMA:7271 - SCTID:190344008 - trabeculae carneae (ventriculus sinister) - uberon - UBERON:0006571 - trabecula carnea of left ventricle - - - - - A trabecula carnea that is part of a heart left ventricle. - OBOL:automatic - - - - - trabeculae carneae (ventriculus sinister) - FMA:7271 - - - - @@ -336361,12 +153215,13 @@ The modern definition of neurosecretion has evolved to include the release of an The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:. FMA also has FMA:29321 but it's not clear how this differs + + + EMAPA:19159 FMA:75383 NCIT:C34245 - SCTID:245445008 UMLS:C0821671 - Wikipedia:Pectinate_line linea pectinata canalis analis pectinate line of anal canal uberon @@ -336377,19 +153232,19 @@ The modern definition of neurosecretion has evolved to include the release of an site of anal membrane UBERON:0006574 pectinate line - http://upload.wikimedia.org/wikipedia/commons/7/7b/Hemorrhoid.png + http://upload.wikimedia.org/wikipedia/commons/7/7b/Hemorrhoid.png The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:. - Wikipedia:Pectinate_line + FMA also has FMA:29321 but it's not clear how this differs - FMA + FMA @@ -336402,7 +153257,7 @@ The modern definition of neurosecretion has evolved to include the release of an linea pectinata canalis analis FMA:75383 - FMA:TA + FMA:TA @@ -336421,20 +153276,20 @@ The modern definition of neurosecretion has evolved to include the release of an dentate line - Wikipedia:Pectinate_line + linea anocutanea - Wikipedia:Pectinate_line + recto-anal junction - Wikipedia:Pectinate_line + @@ -336496,7 +153351,7 @@ The modern definition of neurosecretion has evolved to include the release of an Presumptive structure of the blastula that will develop into endoderm. - http://orcid.org/0000-0002-6601-2165 + @@ -336553,6 +153408,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -336647,7 +153503,7 @@ The modern definition of neurosecretion has evolved to include the release of an Presumptive structure of the blastula that will develop into ectoderm. - http://orcid.org/0000-0002-6601-2165 + @@ -336709,7 +153565,7 @@ The modern definition of neurosecretion has evolved to include the release of an Presumptive structure of the blastula that will develop into mesoderm. - http://orcid.org/0000-0002-6601-2165 + @@ -336743,10 +153599,11 @@ The modern definition of neurosecretion has evolved to include the release of an An outer layer of smooth muscle surrounding a hollow or tubular organ as the bladder, esophagus, large intestine, small intestine, stomach, ureter, uterus, and vagina that often consists of an inner layer of circular fibers serving to narrow the lumen of the organ and an outer layer of longitudinal fibers serving to shorten its length[BTO]. typically smooth muscle, but there may be exceptions - in the upper esophagus, part of the externa is skeletal muscle, rather than smooth muscle. + + + BTO:0004838 - SCTID:86915006 UMLS:C0225358 - Wikipedia:Muscular_layer muscular layer muscularis layer tunica muscularis @@ -336765,13 +153622,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis. - Wikipedia:Muscular_layer + @@ -336789,7 +153646,7 @@ The modern definition of neurosecretion has evolved to include the release of an muscular layer - OBOL:automatic + OBOL:automatic @@ -336808,7 +153665,7 @@ The modern definition of neurosecretion has evolved to include the release of an muscular coat - Wikipedia:Muscularis_externa + @@ -336820,13 +153677,13 @@ The modern definition of neurosecretion has evolved to include the release of an muscularis propria - Wikipedia:Muscularis_externa + transverse muscular fibers - Wikipedia:Muscularis_externa + @@ -336838,7 +153695,7 @@ The modern definition of neurosecretion has evolved to include the release of an tunica muscularis - Wikipedia:Muscularis_externa + @@ -336849,6 +153706,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + @@ -336875,13 +153738,14 @@ The modern definition of neurosecretion has evolved to include the release of an The three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers. In mammals, the diaphragm muscle divides the thoracoabdominal cavity into thorax and abdomen. In most mammals, the diaphragm is a flat sheet with muscle fibers radiating outward from a central tendon, and the diaphragm's apposition to the cranial surface of the liver gives it a dome-shape. Muscle fiber contraction reduces the curvature of the dome, thereby expanding the thoracic cavity and aspirating air into the lungs.[well established][VHOG] + + + EMAPA:17702 FMA:58279 NCIT:C34119 - SCTID:244943002 UMLS:C0230162 VHOG:0001399 - Wikipedia:Central_tendon_of_diaphragm central tendon centrum tendineum centrum tendineum diaphragmatis @@ -336899,7 +153763,7 @@ The modern definition of neurosecretion has evolved to include the release of an - VHOG + VHOG @@ -336910,24 +153774,24 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional The three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers. - MGI:csmith + MGI:csmith MP:0012061 In mammals, the diaphragm muscle divides the thoracoabdominal cavity into thorax and abdomen. In most mammals, the diaphragm is a flat sheet with muscle fibers radiating outward from a central tendon, and the diaphragm's apposition to the cranial surface of the liver gives it a dome-shape. Muscle fiber contraction reduces the curvature of the dome, thereby expanding the thoracic cavity and aspirating air into the lungs.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001399 - VHOG - DOI:10.1016/j.resp.2006.06.003 - http://bgee.unil.ch/ + VHOG + + @@ -336952,7 +153816,7 @@ The modern definition of neurosecretion has evolved to include the release of an centrum tendineum diaphragmatis FMA:58279 - FMA:TA + FMA:TA @@ -336996,7 +153860,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical boundary that adjacent_to a epithelium. - OBOL:automatic + OBOL:automatic @@ -337029,11 +153893,11 @@ The modern definition of neurosecretion has evolved to include the release of an A vein that is part of a vertebral column. + + EMAPA:18255 FMA:76735 MA:0002108 - SCTID:181376008 - Wikipedia:Spinal_veins vena spinalis uberon spinal branch @@ -337044,14 +153908,14 @@ The modern definition of neurosecretion has evolved to include the release of an A vein that is part of a vertebral column. - OBOL:automatic + OBOL:automatic vena spinalis FMA:76735 - FMA:TA + FMA:TA @@ -337070,17 +153934,18 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - + + + + + @@ -337096,28 +153961,30 @@ The modern definition of neurosecretion has evolved to include the release of an - - + + - - + + A conduit enclosed within the vertebral foramen of the vertebrae through which the spinal cord passes. TODO - check neural vs vertebral canal; embryonic vs adult? Canal formed by the vertebral centra ventrally, the pedicels laterally, and the neural arches dorsally that encloses and protects the spinal cord.[AAO] + + + + AAO:0000693 FMA:9680 GAID:242 NCIT:C33869 NCIT:C34221 - SCTID:361746009 UMLS:C0037922 UMLS:C1522467 - Wikipedia:Spinal_canal uberon c. vertebralis foramen vertebrale @@ -337128,23 +153995,23 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0006692 vertebral canal - http://upload.wikimedia.org/wikipedia/commons/3/30/Gray82.png + http://upload.wikimedia.org/wikipedia/commons/3/30/Gray82.png A conduit enclosed within the vertebral foramen of the vertebrae through which the spinal cord passes. - Wikipedia:Spinal_canal - http://orcid.org/0000-0002-6601-2165 + + Canal formed by the vertebral centra ventrally, the pedicels laterally, and the neural arches dorsally that encloses and protects the spinal cord.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000693 - AAO - AAO:LAP + AAO + AAO:LAP @@ -337162,7 +154029,7 @@ The modern definition of neurosecretion has evolved to include the release of an c. vertebralis - Wikipedia:Spinal_canal + @@ -337187,13 +154054,13 @@ The modern definition of neurosecretion has evolved to include the release of an spinal cavity - Wikipedia:Spinal_canal + vertebral canal - Wikipedia:Spinal_canal + @@ -337237,14 +154104,13 @@ The modern definition of neurosecretion has evolved to include the release of an The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm. - + + EFO:0001403 EMAPA:37835 FMA:58342 GAID:896 MESH:D016850 - SCTID:63716004 - Wikipedia:Corneal_limbus ZFA:0005570 cornea limbus corneal limbus @@ -337257,12 +154123,11 @@ The modern definition of neurosecretion has evolved to include the release of an limbus corneae UBERON:0006761 - This location has parts such as blood vessels etc. See PMC2868485, http://www.ncbi.nlm.nih.gov/pubmed/2695343 corneo-scleral junction - http://upload.wikimedia.org/wikipedia/commons/3/3d/Limbus.png + http://upload.wikimedia.org/wikipedia/commons/3/3d/Limbus.png @@ -337274,20 +154139,25 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37835 - MA:th + MA:th corneal limbus FMA:58342 + + + + + corneal limbus GAID:896 corneal-scleral limbus - PMID:17051547 + @@ -337299,7 +154169,7 @@ The modern definition of neurosecretion has evolved to include the release of an limbus corneae - Wikipedia:Corneal_limbus + @@ -337318,7 +154188,7 @@ The modern definition of neurosecretion has evolved to include the release of an limbus corneae - Wikipedia:Corneal_limbus + @@ -337347,6 +154217,8 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is composed primarily of secretory cells. consider splitting epithelium from epithelial tissue + + BTO:0002991 NCIT:C43370 NCIT:C45715 @@ -337360,7 +154232,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is composed primarily of secretory cells. - http://orcid.org/0000-0002-6601-2165 + @@ -337380,6 +154252,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -337403,9 +154276,9 @@ The modern definition of neurosecretion has evolved to include the release of an Also known as loose connective tissue. A pliable, mesh-like tissue with a fluid matrix that functions to cushion and protect body organs.[AAO] relationship loss: subclass connective tissue proper (AAO:0000099)[AAO] cushions body organs + AAO:0000027 FMA:63897 - SCTID:68477002 loose areolar connective tissue uberon areolar tissue @@ -337417,7 +154290,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -337428,7 +154301,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -337440,24 +154313,24 @@ The modern definition of neurosecretion has evolved to include the release of an Also known as loose connective tissue. A pliable, mesh-like tissue with a fluid matrix that functions to cushion and protect body organs.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000027 - AAO - AAO:LAP + AAO + AAO:LAP relationship loss: subclass connective tissue proper (AAO:0000099)[AAO] - 2012-06-20 + 2012-06-20 AAO:0000027 - AAO + AAO cushions body organs - AAO + AAO @@ -337474,38 +154347,60 @@ The modern definition of neurosecretion has evolved to include the release of an - + - + - + - - + + - + + - + - The supporting bundles of muscular fibers lining the walls of the atria[MP]. - Not present in any AO. Note that WP states that trabecular carnea are ventricular and 'They should not be confused with the pectinate muscles, which are present in the right and left atria only' + + + + + + + An anatomical space that surrounded_by a trachea. + + FMA:7469 + lumen of cartilaginous trachea + tracheal lumen uberon - UBERON:0006828 - trabecula carnea of atrium + UBERON:0006833 + lumen of trachea - + - The supporting bundles of muscular fibers lining the walls of the atria[MP]. - MP:0010581 + An anatomical space that surrounded_by a trachea. + OBOL:automatic + + + + + lumen of cartilaginous trachea + OBOL:automatic + + + + + tracheal lumen + FMA:7469 @@ -337546,6 +154441,7 @@ The modern definition of neurosecretion has evolved to include the release of an A subdivision of a the reproductive tract in a female organism that is the site of embryo development. uterus + FBbt:00004924 TADS:0000421 WBbt:0006760 uberon @@ -337557,7 +154453,7 @@ The modern definition of neurosecretion has evolved to include the release of an A subdivision of a the reproductive tract in a female organism that is the site of embryo development. - http://orcid.org/0000-0002-6601-2165 + @@ -337583,11 +154479,11 @@ The modern definition of neurosecretion has evolved to include the release of an Vein that is central to a lobule in the liver. central vein + + FMA:17544 NCIT:C32281 - SCTID:272023004 TAO:0005168 - Wikipedia:Central_veins_of_liver ZFA:0005168 terminal branch of hepatic vein terminal hepatic venule @@ -337634,7 +154530,18 @@ The modern definition of neurosecretion has evolved to include the release of an - + + + + + + + + + + + + @@ -337648,17 +154555,15 @@ The modern definition of neurosecretion has evolved to include the release of an groove UBERON:0006846 - Surface groove is modelled as immaterial - see https://github.com/obophenotype/uberon/issues/2667 for discussion surface groove - https://github.com/obophenotype/uberon/issues/2667 A furrow or an incomplete tube. + AEO:0000161 AEO:JB - https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/4 @@ -337700,7 +154605,7 @@ The modern definition of neurosecretion has evolved to include the release of an The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus. - http://orcid.org/0000-0002-6601-2165 + @@ -337745,7 +154650,7 @@ The modern definition of neurosecretion has evolved to include the release of an A vasculature that is part of a organ. - OBOL:automatic + OBOL:automatic @@ -337776,6 +154681,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -337802,13 +154708,13 @@ The modern definition of neurosecretion has evolved to include the release of an A vasculature that is part of a liver. - OBOL:automatic + OBOL:automatic the EHDAA2 term and the FMA term may not be exact equivalents - check - EHDAA2 + EHDAA2 @@ -337896,7 +154802,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -337907,7 +154813,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -337918,14 +154824,14 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 - XAO + EHDAA2 + XAO A head mesenchyme that develops_from a mesoderm. - OBOL:automatic + OBOL:automatic @@ -337970,6 +154876,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -337991,7 +154898,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a mandibular prominence. - OBOL:automatic + OBOL:automatic @@ -338003,7 +154910,7 @@ The modern definition of neurosecretion has evolved to include the release of an mesenchyme of mandibular prominence - https://orcid.org/0000-0002-6601-2165 + @@ -338023,6 +154930,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -338053,13 +154961,13 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical space that surrounded_by a digestive tract. - OBOL:automatic + OBOL:automatic digestive tract lumen - https://orcid.org/0000-0002-6601-2165 + @@ -338077,13 +154985,13 @@ The modern definition of neurosecretion has evolved to include the release of an lumen of alimentary tract - https://orcid.org/0000-0002-6601-2165 + lumen of digestive tract - https://orcid.org/0000-0002-6601-2165 + @@ -338128,15 +155036,15 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a lip. - OBOL:automatic + OBOL:automatic The thick, high squamous-stratified epithelium that covers the lips. It contains abundant melanocytes, many mucous cells and has well differentiated taste buds.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005334 - TAO + TAO ZFIN:ZDB-PUB-060921-12 @@ -338165,11 +155073,12 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium characterised by its most superficial layer consisting of squamous epithelial cells. FBbt:00007028 (squamous epithelium) A type of epithelium that is made up of flattened cells which are arranged with their long axes in the plane of the epithelium + + + BTO:0002072 NCIT:C12848 - SCTID:40118003 UMLS:C0221909 - Wikipedia:Squamous_epithelium uberon UBERON:0006914 squamous epithelium @@ -338178,7 +155087,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium characterised by its most superficial layer consisting of squamous epithelial cells. - Wikipedia:Squamous_epithelium + @@ -338218,10 +155127,11 @@ The modern definition of neurosecretion has evolved to include the release of an Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA]. + + FMA:45563 NCIT:C13180 UMLS:C0836131 - Wikipedia:Stratified_squamous_epithelium epithelium stratificatum squamosum uberon UBERON:0006915 @@ -338232,8 +155142,8 @@ The modern definition of neurosecretion has evolved to include the release of an Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA]. + FMA:45563 - Wikipedia:Stratified_squamous_epithelium @@ -338274,6 +155184,7 @@ The modern definition of neurosecretion has evolved to include the release of an A squamous epithelium that is part of a esophagus. MA introduces basal and squamous subtypes of esophagus epithelium; consider adding the FMA class 'epithelium of esophagus' here, because it is classified as squamous. BTO also has a singleton subclass + BTO:0003635 CALOHA:TS-1250 EMAPA:35324 @@ -338292,13 +155203,13 @@ The modern definition of neurosecretion has evolved to include the release of an A squamous epithelium that is part of a esophagus. - OBOL:automatic + OBOL:automatic MA introduces basal and squamous subtypes of esophagus epithelium; consider adding the FMA class 'epithelium of esophagus' here, because it is classified as squamous. BTO also has a singleton subclass - MA + MA @@ -338310,13 +155221,13 @@ The modern definition of neurosecretion has evolved to include the release of an esophageal squamous epithelium - OBOL:automatic + OBOL:automatic squamous epithelium of esophagus - OBOL:automatic + OBOL:automatic @@ -338361,7 +155272,7 @@ The modern definition of neurosecretion has evolved to include the release of an A squamous epithelium that is part of a stomach. - OBOL:automatic + OBOL:automatic @@ -338417,13 +155328,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands. - ISBN:0073040584 + ISBN:0073040584 @@ -338475,7 +155386,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any gland that is part of the digestive system. - UBERON:cjm + UBERON:cjm @@ -338509,6 +155420,7 @@ The modern definition of neurosecretion has evolved to include the release of an Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA]. + FMA:64800 NCIT:C13182 UMLS:C0225337 @@ -338594,7 +155506,7 @@ The modern definition of neurosecretion has evolved to include the release of an Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region. - http://orcid.org/0000-0002-6601-2165 + @@ -338605,65 +155517,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - - - - - - Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue. - note that the definition sourced from Dorlands say 'simple columnar', but FMA says atypical - CALOHA:TS-0682 - FMA:62410 - SCTID:309045006 - uberon - neuroepithelium - UBERON:0006934 - sensory epithelium - - - - - Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue. - BTO:0000314 - - - - - note that the definition sourced from Dorlands say 'simple columnar', but FMA says atypical - FMA - - - - - neuroepithelium - BTO:0000314 - - - - - @@ -338678,6 +155531,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -338694,14 +155548,15 @@ The modern definition of neurosecretion has evolved to include the release of an The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis. + + + CALOHA:TS-1246 EMAPA:28880 FMA:18626 MA:0002991 NCIT:C33638 - SCTID:259306002 UMLS:C0737271 - Wikipedia:Stroma_of_ovary interstitial tissue of ovary ovarian stroma ovary stroma @@ -338722,13 +155577,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis. - Wikipedia:Stroma_of_ovary + @@ -338758,7 +155613,7 @@ The modern definition of neurosecretion has evolved to include the release of an stroma of the ovary - Wikipedia:Stroma_of_ovary + @@ -338770,7 +155625,7 @@ The modern definition of neurosecretion has evolved to include the release of an stroma ovarii - Wikipedia:Stroma_of_ovary + @@ -338779,7 +155634,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -338868,13 +155723,13 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA A capillary that is part of the coronary system. - http://orcid.org/0000-0002-6601-2165 + @@ -338890,6 +155745,7 @@ The modern definition of neurosecretion has evolved to include the release of an A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n. + BILA:0000010 CARO:0001002 EHDAA2_RETIRED:0003192 @@ -338955,13 +155811,13 @@ The modern definition of neurosecretion has evolved to include the release of an The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]. consider FBbt:00005541 ! cardiogenic mesoderm review EHDAA2 placement + AAO:0011021 BILA:0000051 EFO:0000315 EHDAA2:0000214 EHDAA:385 FMA:293143 - SCTID:360387000 VHOG:0001641 XAO:0000235 cardiogenic splanchnopleure @@ -338979,9 +155835,9 @@ The modern definition of neurosecretion has evolved to include the release of an The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]. + + XAO:0000235 - http://www.drugs.com/dict/cardiogenic-mesoderm.html - https://github.com/obophenotype/insect_neuroanatomy_ontology/issues/7 @@ -338999,13 +155855,13 @@ The modern definition of neurosecretion has evolved to include the release of an cardiogenic mesoderm - http://www.drugs.com/dict/cardiogenic-mesoderm.html + cardiogenic region - http://orcid.org/0000-0002-6601-2165 + @@ -339057,7 +155913,7 @@ The modern definition of neurosecretion has evolved to include the release of an Organism at the cleavage stage. - OBOL:automatic + OBOL:automatic @@ -339102,9 +155958,10 @@ The modern definition of neurosecretion has evolved to include the release of an The endodermal cells generate only the lining of the digestive tube and its glands; mesodermal mesenchyme cells will surround this tube to provide the muscles for peristalsis + + BILA:0000084 NCIT:C34268 - SCTID:360394002 UMLS:C1514442 future digestive tract future digestive tube @@ -339183,7 +156040,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -339194,7 +156051,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -339234,9 +156091,9 @@ The modern definition of neurosecretion has evolved to include the release of an A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis + SPD:0000130 TADS:0000147 - http://www.sciencemag.org/content/313/5795/1922/F1.large.jpg dorsal tube heart uberon @@ -339267,7 +156124,7 @@ The modern definition of neurosecretion has evolved to include the release of an dorsal tube - Wikipedia:Heart + @@ -339299,6 +156156,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -339322,7 +156180,7 @@ The modern definition of neurosecretion has evolved to include the release of an Ganglion which is located in the trunk. - ZFIN:curator + ZFIN:curator @@ -339335,7 +156193,7 @@ The modern definition of neurosecretion has evolved to include the release of an trunk ganglia ZFA:0001573 - + @@ -339365,16 +156223,16 @@ The modern definition of neurosecretion has evolved to include the release of an An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. - ZFIN:ZDB-PUB-961014-576 + ZFIN:ZDB-PUB-961014-576 An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000131 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -339388,6 +156246,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -339422,7 +156281,7 @@ The modern definition of neurosecretion has evolved to include the release of an An embryonic structure that will either develop into a post-anal tail or recede into a vestigial remnant of the tail. - http://orcid.org/0000-0002-6601-2165 + @@ -339460,6 +156319,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -339484,7 +156344,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical cavity that surrounded_by a midgut. - OBOL:automatic + OBOL:automatic @@ -339510,6 +156370,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -339534,7 +156395,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical cavity that surrounded_by a hindgut. - OBOL:automatic + OBOL:automatic @@ -339560,6 +156421,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -339584,7 +156446,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical cavity that surrounded_by a anal canal. - OBOL:automatic + OBOL:automatic @@ -339610,6 +156472,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -339623,9 +156486,9 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical cavity that surrounded_by a colon. + EMAPA:18945 FMA:18374 - SCTID:362156004 colon lumen uberon colonic lumen @@ -339636,7 +156499,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical cavity that surrounded_by a colon. - OBOL:automatic + OBOL:automatic @@ -339676,10 +156539,10 @@ The modern definition of neurosecretion has evolved to include the release of an A lamina propria that is part of a colonic mucosa. + EMAPA:27395 FMA:15657 MA:0003196 - SCTID:113284008 colonic lamina propria lamina propria mucosae of colon lamina propria of colonic mucosa @@ -339693,7 +156556,7 @@ The modern definition of neurosecretion has evolved to include the release of an A lamina propria that is part of a colonic mucosa. - OBOL:automatic + OBOL:automatic @@ -339744,10 +156607,10 @@ The modern definition of neurosecretion has evolved to include the release of an A mesothelium that is part of a serous pericardium. + BTO:0003157 EMAPA:16133 FMA:18149 - SCTID:67300002 mesothelium of pericardium pericardial mesothelium serous pericardium mesothelium @@ -339759,7 +156622,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mesothelium that is part of a serous pericardium. - OBOL:automatic + OBOL:automatic @@ -339796,7 +156659,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -339824,19 +156686,21 @@ The modern definition of neurosecretion has evolved to include the release of an The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis. + + CALOHA:TS-0085 FMA:21426 - Wikipedia:Bone_marrow#Stroma bone marrow stroma uberon UBERON:0007195 + stroma of bone marrow The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis. - Wikipedia:Bone_marrow#Stroma + @@ -339847,6 +156711,85 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells. + + UBERON:0004102 + + + FMA:7393 + NCIT:C117875 + arbor tracheobronchialis + uberon + tracheobronchial system + UBERON:0007196 + + + + tracheobronchial tree + + + + + + + + + + + Wikipedia + + + + + The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells. + + + + + + arbor tracheobronchialis + FMA:7393 + FMA:TA + + + + + + tracheobronchial system + HP:0005607 + + + + @@ -339860,7 +156803,7 @@ The modern definition of neurosecretion has evolved to include the release of an The vasculature consisting of brachiocephalic arteries and veins. - http://orcid.org/0000-0002-6601-2165 + @@ -339908,13 +156851,13 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA Mesenchyme that develops_from a cranial neural crest. - OBOL:automatic + OBOL:automatic @@ -339963,7 +156906,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that develops_from a trunk neural crest. - OBOL:automatic + OBOL:automatic @@ -339977,6 +156920,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -340012,17 +156956,17 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000510 - VHOG + VHOG + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) - http://bgee.unil.ch/ @@ -340048,6 +156992,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -340080,17 +157025,17 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000511 - VHOG + VHOG + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) - http://bgee.unil.ch/ @@ -340123,11 +157068,12 @@ The modern definition of neurosecretion has evolved to include the release of an A tunica media that is part of a artery. + + EMAPA:36294 EV:0100029 FMA:14273 NCIT:C49321 - SCTID:84300001 UMLS:C1710627 arterial media tunica media (arteriae) @@ -340139,7 +157085,7 @@ The modern definition of neurosecretion has evolved to include the release of an A tunica media that is part of a artery. - OBOL:automatic + OBOL:automatic @@ -340196,10 +157142,10 @@ The modern definition of neurosecretion has evolved to include the release of an A tunica adventitia that is part of a artery. + EMAPA:36295 EV:0100030 FMA:14274 - SCTID:113261001 arterial adventitia tunica externa (adventitia)(arteriae) uberon @@ -340215,13 +157161,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A tunica adventitia that is part of a artery. - OBOL:automatic + OBOL:automatic @@ -340260,10 +157206,10 @@ The modern definition of neurosecretion has evolved to include the release of an A tunica adventitia that is part of a vein. + EMAPA:36310 EV:0100034 FMA:14355 - SCTID:13202006 tunica externa (adventitia)(venae) venous adventitia uberon @@ -340274,7 +157220,7 @@ The modern definition of neurosecretion has evolved to include the release of an A tunica adventitia that is part of a vein. - OBOL:automatic + OBOL:automatic @@ -340314,10 +157260,10 @@ The modern definition of neurosecretion has evolved to include the release of an A tunica intima that is part of a vein. + EMAPA:36308 EV:0100032 FMA:14353 - SCTID:2436009 tunica interna (intima)(venae) venous intima uberon @@ -340328,7 +157274,7 @@ The modern definition of neurosecretion has evolved to include the release of an A tunica intima that is part of a vein. - OBOL:automatic + OBOL:automatic @@ -340367,10 +157313,10 @@ The modern definition of neurosecretion has evolved to include the release of an A tunica media that is part of a vein. + EMAPA:36309 EV:0100033 FMA:14354 - SCTID:42049001 tunica media (venae) venous media uberon @@ -340381,7 +157327,7 @@ The modern definition of neurosecretion has evolved to include the release of an A tunica media that is part of a vein. - OBOL:automatic + OBOL:automatic @@ -340433,7 +157379,7 @@ The modern definition of neurosecretion has evolved to include the release of an Gray matter of the central nervous system which is a collection of clustered nuclei. - http://orcid.org/0000-0002-6601-2165 + @@ -340462,8 +157408,8 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei. this class exists largely for consistency with the FMA. It is defined trivially with respect to the SOC. The class may be removed in future. + FMA:72246 - SCTID:369024009 superior olivary complex nucleus uberon UBERON:0007247 @@ -340475,7 +157421,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei. - http://orcid.org/0000-0002-6601-2165 + @@ -340486,6 +157432,61 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A pre-cartilage condensation that is part of a trachea. + EHDAA2:0002070 + EHDAA:7082 + uberon + UBERON:0007267 + trachea pre-cartilage rings + + + + + + + + + + + EHDAA2 + + + + + A pre-cartilage condensation that is part of a trachea. + OBOL:automatic + + + + @@ -340524,7 +157525,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any collection of muscles that is part of a pectoral appendage. - OBOL:automatic + OBOL:automatic @@ -340578,15 +157579,15 @@ The modern definition of neurosecretion has evolved to include the release of an Any collection of muscles that is part of a pelvic appendage. - OBOL:automatic + OBOL:automatic Musculature that is part of the pelvic fin.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000258 - TAO + TAO TAO:curator @@ -340633,7 +157634,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any collection of muscles that is part of an appendage. - OBOL:automatic + OBOL:automatic @@ -340695,21 +157696,21 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle. VSAO:0005000 - VSAO:NI + VSAO:NI cheiropterygium VSAO:0005000 - VSAO:NI + VSAO:NI @@ -340761,13 +157762,13 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO The collection of all skeletal elements in a pelvic appendage region. - https://orcid.org/0000-0002-6601-2165 + @@ -340814,13 +157815,13 @@ The modern definition of neurosecretion has evolved to include the release of an The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure. TODO - unify naming conventions The embryonic rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. Rhombomeres Rh7-Rh4 form the myelencephalon that will give the medulla oblongata. Rhombomeres Rh3-Rh1 form the metencephalon that will form the pons and the cerebellum[NPX:PDR]. + BAMS:HB CALOHA:TS-2118 EFO:0003440 EHDAA2:0001630 FMA:295640 TAO:0000569 - Wikipedia:Rhombencephalon ZFA:0000569 presumptive rhombencephalon uberon @@ -340851,13 +157852,13 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure. - Wikipedia:Rhombencephalon + @@ -340881,7 +157882,7 @@ The modern definition of neurosecretion has evolved to include the release of an future hindbrain - https://orcid.org/0000-0002-6601-2165 + @@ -340935,7 +157936,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -340991,16 +157992,16 @@ The modern definition of neurosecretion has evolved to include the release of an A presumptive structure that has the potential to develop into a endocardium. - OBOL:automatic + OBOL:automatic Portion of tissue that is part of the heart tube and will become the endocardium.[TAO] - 2012-08-14 + 2012-08-14 TAO:0002233 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -341053,7 +158054,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -341065,7 +158066,7 @@ The modern definition of neurosecretion has evolved to include the release of an presumptive MHB - https://orcid.org/0000-0002-6601-2165 + @@ -341129,14 +158130,14 @@ The modern definition of neurosecretion has evolved to include the release of an A presumptive structure that has the potential to develop into a presomitic mesoderm. - OBOL:automatic + OBOL:automatic presumptive segmental plates ZFA:0000053 - + @@ -341191,16 +158192,16 @@ The modern definition of neurosecretion has evolved to include the release of an A presumptive structure that has the potential to develop into a neural plate. - OBOL:automatic + OBOL:automatic Region of the gastrula which gives rise to the neural plate.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000063 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -341278,20 +158279,20 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/issues/1277 + The part of the blastula that has the potential to develop into a paraxial mesoderm. - UBERON:cjm - https://github.com/obophenotype/uberon/issues/1277 + + UBERON:cjm future paraxial mesenchyme - UBERON:cjm + UBERON:cjm @@ -341329,7 +158330,7 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a pectoral appendage. - OBOL:automatic + OBOL:automatic @@ -341381,7 +158382,7 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a limb/fin. - OBOL:automatic + OBOL:automatic @@ -341413,6 +158414,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -341432,7 +158434,7 @@ The modern definition of neurosecretion has evolved to include the release of an A vasculature that is part of a pectoral appendage. - OBOL:automatic + OBOL:automatic @@ -341458,6 +158460,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -341477,7 +158480,7 @@ The modern definition of neurosecretion has evolved to include the release of an A vasculature that is part of a chordate pharynx. - OBOL:automatic + OBOL:automatic @@ -341521,7 +158524,7 @@ The modern definition of neurosecretion has evolved to include the release of an A vasculature that is part of a limb/fin. - OBOL:automatic + OBOL:automatic @@ -341536,7 +158539,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -341576,13 +158578,13 @@ The modern definition of neurosecretion has evolved to include the release of an A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans. - ISBN:0123813611 + ISBN:0123813611 EMAPA:37710 - MA:th + MA:th @@ -341667,15 +158669,15 @@ The modern definition of neurosecretion has evolved to include the release of an Duct connecting the pancreas with the intestine. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] These data show that ducts within the zebrafish pancreas originally arise in situ from isolated progenitor cells rather than arising from reiterative branching of the pancreatic epithelium. This process of pancreatic duct formation in zebrafish may be analogous to the mechanism of duct formation in the mammalian mammary and salivary glands. (...) A related mechanism of duct formation has also been proposed to occur within the mammalian pancreatic epithelium.[uncertain][VHOG] in EHDAA2, the dorsal and ventral ducts are classified as epithelial sacs - review after overhaul of duct/epithelia terms + + EHDAA:9194 EMAPA:32952 FMA:10419 MA:0000124 MESH:D010183 - SCTID:181278006 TAO:0001372 VHOG:0000254 - Wikipedia:Pancreatic_duct ZFA:0001372 duct of pancreas pancreas duct @@ -341686,13 +158688,13 @@ The modern definition of neurosecretion has evolved to include the release of an pancreatic duct - http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1100.png + http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1100.png - ZFA + ZFA @@ -341703,62 +158705,62 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA A duct that collects and carries secretions of the exocrine pancreas to the intestine. + + + + + GOC:cvs GOC:ymb - Wikipedia:Pancreatic_duct - https://github.com/obophenotype/uberon/issues/1250 - https://orcid.org/0000-0002-2244-7917 - https://orcid.org/0000-0002-6601-2165 - https://orcid.org/0000-0002-9900-7880 Duct connecting the pancreas with the intestine. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000254 - VHOG - http://bgee.unil.ch/ + VHOG + These data show that ducts within the zebrafish pancreas originally arise in situ from isolated progenitor cells rather than arising from reiterative branching of the pancreatic epithelium. This process of pancreatic duct formation in zebrafish may be analogous to the mechanism of duct formation in the mammalian mammary and salivary glands. (...) A related mechanism of duct formation has also been proposed to occur within the mammalian pancreatic epithelium.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000254 - VHOG + VHOG + DOI:10.1016/j.ydbio.2005.04.035 Yee NS, Lorent K, Pack M, Exocrine pancreas development in zebrafish. Developmental Biology (2005) - http://bgee.unil.ch/ in EHDAA2, the dorsal and ventral ducts are classified as epithelial sacs - review after overhaul of duct/epithelia terms - EHDAA2 + EHDAA2 duct of pancreas - OBOL:accepted + OBOL:accepted pancreas duct - OBOL:accepted + OBOL:accepted ductus pancreaticus - Wikipedia:Pancreatic_duct + @@ -341782,8 +158784,8 @@ The modern definition of neurosecretion has evolved to include the release of an A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones. check subclasses to verify if they refer to a multi-tissue structure or a subdivision of the skeleton + CALOHA:TS-2212 - Wikipedia:Palate roof of buccal cavity roof of oral cavity uberon @@ -341798,7 +158800,7 @@ The modern definition of neurosecretion has evolved to include the release of an A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones. - https://orcid.org/0000-0002-6601-2165 + @@ -341849,13 +158851,13 @@ The modern definition of neurosecretion has evolved to include the release of an The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]. this grouping class exists primarily to align with GO - see GO:0008544. + BSA:0000073 BTO:0000313 FBbt:00004993 HAO:0000298 TADS:0000109 WBbt:0005733 - Wikipedia:Epidermis_(zoology) epidermis epidermis (sensu Metazoa) outer epidermal layer @@ -341876,7 +158878,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia:Epidermis_(zoology) + @@ -341944,24 +158946,24 @@ The modern definition of neurosecretion has evolved to include the release of an Outermost layer of cells surrounding the embryo. - http://orcid.org/0000-0002-6601-2165 + Outermost monolayer of cells surrounding the embryo that become very flattened in the blastula and give rise to the periderm. Sometimes used synonymously with periderm. Kimmel et al, 1995.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000086 - TAO - ZFIN:curator + TAO + ZFIN:curator relationship loss: develops_from superficial blastomere (TAO:0001484)[TAO] - 2012-08-14 + 2012-08-14 TAO:0000086 - TAO + TAO @@ -341973,7 +158975,7 @@ The modern definition of neurosecretion has evolved to include the release of an enveloping layer - ZFIN:ZDB-PUB-961014-576 + ZFIN:ZDB-PUB-961014-576 @@ -342018,16 +159020,16 @@ The modern definition of neurosecretion has evolved to include the release of an A cartilage tissue that is part of a paired limb or fin. - http://orcid.org/0000-0002-6601-2165 + Cartilage which is part of one of the paired fins.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001543 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -342079,16 +159081,16 @@ The modern definition of neurosecretion has evolved to include the release of an A cartilage tissue that is part of a pectoral appendage. - OBOL:automatic + OBOL:automatic Cartilage which is part of the pectoral fin.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000257 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -342146,16 +159148,16 @@ The modern definition of neurosecretion has evolved to include the release of an A cartilage tissue that is part of a pelvic appendage. - OBOL:automatic + OBOL:automatic Cartilage which is part of the pelvic fin.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001459 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -342202,13 +159204,13 @@ The modern definition of neurosecretion has evolved to include the release of an A nucleus of brain that spans a midbrain tegmentum. - OBOL:automatic + OBOL:automatic tegmental nuclei - + @@ -342344,7 +159346,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -342371,7 +159373,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -342398,7 +159400,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -342437,9 +159439,9 @@ The modern definition of neurosecretion has evolved to include the release of an A ring of smooth muscle cells whose contraction closes the opening of the ring. + AEO:0000143 EHDAA2:0003143 - SCTID:362915001 uberon UBERON:0007521 smooth muscle sphincter @@ -342499,6 +159501,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -342517,7 +159520,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -342528,7 +159531,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -342611,7 +159614,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -342652,7 +159655,7 @@ The modern definition of neurosecretion has evolved to include the release of an Epithelium bearing vibratile cilia on the free surface. - http://medical-dictionary.thefreedictionary.com/ciliated+epithelium + @@ -342706,14 +159709,14 @@ The modern definition of neurosecretion has evolved to include the release of an - BTO + BTO A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]. + BTO:0001338 - http://www.britannica.com/EBchecked/topic/578563/synovial-tissue @@ -342725,7 +159728,7 @@ The modern definition of neurosecretion has evolved to include the release of an stratum synoviale - FMA:TA + FMA:TA @@ -342790,7 +159793,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical cavity that surrounded_by a synovial joint. - OBOL:automatic + OBOL:automatic @@ -342893,8 +159896,8 @@ The modern definition of neurosecretion has evolved to include the release of an A neural nucleus that is part of a medulla oblongata. + FMA:258772 - SCTID:304943004 uberon UBERON:0007635 nucleus of medulla oblongata @@ -342903,7 +159906,7 @@ The modern definition of neurosecretion has evolved to include the release of an A neural nucleus that is part of a medulla oblongata. - OBOL:automatic + OBOL:automatic @@ -342932,6 +159935,8 @@ The modern definition of neurosecretion has evolved to include the release of an The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP]. in MA and FMA this is part of the pons / pontime tegmentum. We weaken this to overlaps to avoid inconsistency. In NIF this is a composite structure spanning multiple regions, which is more appropriate. + + BIRNLEX:4096 BM:V CALOHA:TS-2077 @@ -342939,20 +159944,19 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:71248 HBA:9203 UMLS:C0040999 - Wikipedia:Trigeminal_nerve_nuclei neuronames:2021 trigeminal nuclei uberon nuclei trigemini UBERON:0007641 trigeminal nuclear complex - http://upload.wikimedia.org/wikipedia/commons/3/30/Gray696.png + http://upload.wikimedia.org/wikipedia/commons/3/30/Gray696.png - FMA + FMA @@ -342963,19 +159967,19 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP]. - Wikipedia:Trigeminal_nerve_nuclei + in MA and FMA this is part of the pons / pontime tegmentum. We weaken this to overlaps to avoid inconsistency. In NIF this is a composite structure spanning multiple regions, which is more appropriate. - MA + MA @@ -342993,7 +159997,7 @@ The modern definition of neurosecretion has evolved to include the release of an nuclei trigemini - Wikipedia:Trigeminal_nerve_nuclei + @@ -343011,16 +160015,12 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical structure that connects two structures. - - - junction + FMA:5898 - SCTID:91833003 anatomical junction uberon UBERON:0007651 - anatomical junction @@ -343028,13 +160028,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA An anatomical structure that connects two structures. - http://code.google.com/p/caro2/issues/detail?id=15 + @@ -343063,7 +160063,7 @@ The modern definition of neurosecretion has evolved to include the release of an A sphincter that is part of an esophagus. check for specific subtypes across species. Note mammals have upper and lower, but lower is really part of cardia and thus is not classified under here - SCTID:277765007 + uberon UBERON:0007652 esophageal sphincter @@ -343072,7 +160072,7 @@ The modern definition of neurosecretion has evolved to include the release of an A sphincter that is part of an esophagus. - http://orcid.org/0000-0002-6601-2165 + @@ -343090,11 +160090,11 @@ The modern definition of neurosecretion has evolved to include the release of an Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue. field + AEO:0000170 EFO:0001649 EHDAA2:0003170 FBbt:00005426 - Wikipedia:Anlage_(biology) developmental field uberon future organ @@ -343113,15 +160113,15 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO FBbt Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue. + FBbt:00005426 - http://flybase.org/reports/FBrf0178740.html @@ -343150,7 +160150,6 @@ The modern definition of neurosecretion has evolved to include the release of an - . EFO:0003626 EHDAA2:0001457 EHDAA:962 @@ -343172,7 +160171,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -343183,7 +160182,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -343194,13 +160193,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 - - - - - . - http://dev.biologists.org/content/128/22/4573.full + EHDAA2 @@ -343273,14 +160266,14 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a reproductive organ. - OBOL:automatic - https://github.com/obophenotype/uberon/issues/1158 + + OBOL:automatic - Wikipedia + Wikipedia @@ -343319,7 +160312,7 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that is part of a epidermis. - OBOL:automatic + OBOL:automatic @@ -343352,6 +160345,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -343399,7 +160393,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces. - http://medical-dictionary.thefreedictionary.com/transudate + @@ -343428,7 +160422,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any fluid produced by a serous gland. serous fluid - Wikipedia:Serous_fluid + serosal fluid serous gland fluid uberon @@ -343439,13 +160433,13 @@ The modern definition of neurosecretion has evolved to include the release of an Any fluid produced by a serous gland. - UBERON:cjm + UBERON:cjm serosal fluid - Wikipedia:Serous_fluid + @@ -343462,9 +160456,9 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that consists of all blood and lymph vessels. consider merging with vasculature - The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System]. in both MA and BTO, the arterial system and venous sytem are subtypes of the vascular system + BTO:0001085 CALOHA:TS-2053 EHDAA2:0004520 @@ -343474,7 +160468,6 @@ The modern definition of neurosecretion has evolved to include the release of an UMLS:C0489903 uberon UBERON:0007798 - vascular system @@ -343487,13 +160480,13 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA Anatomical system that consists of all blood and lymph vessels. - http://orcid.org/0000-0002-6601-2165 + @@ -343505,7 +160498,7 @@ The modern definition of neurosecretion has evolved to include the release of an in both MA and BTO, the arterial system and venous sytem are subtypes of the vascular system - MA + MA @@ -343556,10 +160549,10 @@ The modern definition of neurosecretion has evolved to include the release of an Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots. + + CALOHA:paula - MGI:csmith - http://orcid.org/0000-0002-6601-2165 - https://github.com/obophenotype/uberon/issues/259 + MGI:csmith @@ -343586,6 +160579,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -343611,12 +160605,13 @@ The modern definition of neurosecretion has evolved to include the release of an The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae. + + CALOHA:TS-2356 EV:0100009 FMA:280881 MA:0000006 NCIT:C12418 - SCTID:361355005 UMLS:C0460004 WikipediaCategory:Head_and_neck galen:HeadAndNeck @@ -343634,13 +160629,13 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae. - https://orcid.org/0000-0002-6601-2165 + @@ -343652,19 +160647,19 @@ The modern definition of neurosecretion has evolved to include the release of an cephalic area - https://github.com/obophenotype/uberon/issues/379 + cephalic part of animal - Wikipedia:Head + cephalic region - https://github.com/obophenotype/uberon/issues/379 + @@ -343689,6 +160684,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -343741,6 +160737,7 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical structure that is the terminal, flexible posterior appendage of the organism.[AAO] Organism subdivision which is the part of the body posterior to the vent which includes the anal and caudal fins.[TAO] present at some time in chordate life history (eg in Urochordates, present only in free-swimming larvae). Function: propellor locomotion (in some species) + AAO:0010338 EMAPA:16748 MA:0000008 @@ -343769,31 +160766,31 @@ The modern definition of neurosecretion has evolved to include the release of an possible exception in hemichordates - cjm + cjm A tail that extends from the posterior tip of the organism to the anus, contains muscle and skeleton. - https://orcid.org/0000-0002-6601-2165 + Anatomical structure that is the terminal, flexible posterior appendage of the organism.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010338 - AAO - AAO:EJS + AAO + AAO:EJS Organism subdivision which is the part of the body posterior to the vent which includes the anal and caudal fins.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001117 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -343805,7 +160802,7 @@ The modern definition of neurosecretion has evolved to include the release of an post-anal fin tail - http://purl.oboibrary.org/obo/uberon/tracker/185 + @@ -343871,23 +160868,23 @@ The modern definition of neurosecretion has evolved to include the release of an An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). - UBERONREF:0000003 - https://orcid.org/0000-0002-6601-2165 + + UBERONREF:0000003 An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). There are only two instances of appendage girdle regions per organism.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000303 - VSAO - https://orcid.org/0000-0002-6601-2165 + VSAO + EMAPA:37854 - MA:th + MA:th @@ -343962,7 +160959,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -343973,13 +160970,13 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA Mesentery that is located in the peritoneum. - UBERON:cjm + UBERON:cjm @@ -344029,7 +161026,7 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a appendage girdle region. - OBOL:automatic + OBOL:automatic @@ -344069,13 +161066,11 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a pectoral girdle region. - EMAPA:35669 MA:0000292 bone of pectoral girdle uberon UBERON:0007829 - pectoral girdle bone @@ -344083,13 +161078,13 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA A bone that is part of a pectoral girdle region. - OBOL:automatic + OBOL:automatic @@ -344128,18 +161123,17 @@ The modern definition of neurosecretion has evolved to include the release of an A bone element or fused bone that is part of pelvic girdle. check sacrum, coccyx (MA does NOT include these) - typically the ilium, ischium and pubis. These can alternately be considered individual bones, or zones of a single fused bone + + EMAPA:18028 MA:0000293 NCIT:C33287 - SCTID:426214007 UMLS:C0030786 bone of pelvic girdle pelvic girdle bone uberon UBERON:0007830 - pelvic girdle bone/zone @@ -344148,13 +161142,13 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA A bone element or fused bone that is part of pelvic girdle. - https://orcid.org/0000-0002-6601-2165 + @@ -344220,6 +161214,8 @@ The modern definition of neurosecretion has evolved to include the release of an Skeletal structure immediately behind the head attached to the vertebral column by muscles and supporting the forelimbs.[AAO] The pectoral girdle is clearly of dual origin, composed of dermal as well as endochondral bones. The endochondral component, the scapulocoracoid, evolved by fusion or enlargment of several basal fin elements. (...) The dermal component of the shoulder girdle evolved from dermal bones of the body's surface. (...) Like endochondral bones, these dermal bones were passed along to tetrapods (...).[well established][VHOG] Note that the VSAO and many ontologies use the label 'pectoral girdle' to denote the skeletal region specifically. + + AAO:0000422 AAO:0000754 EFO:0000946 @@ -344232,7 +161228,6 @@ The modern definition of neurosecretion has evolved to include the release of an UMLS:C0427245 VHOG:0001156 VSAO:0000156 - Wikipedia:Pectoral_girdle XAO:0003063 ZFA:0000407 skeletal parts of pectoral girdle @@ -344245,7 +161240,7 @@ The modern definition of neurosecretion has evolved to include the release of an pectoral girdle skeleton - http://upload.wikimedia.org/wikipedia/commons/2/22/Pectoral_girdle_front_diagram.svg + http://upload.wikimedia.org/wikipedia/commons/2/22/Pectoral_girdle_front_diagram.svg @@ -344256,56 +161251,56 @@ The modern definition of neurosecretion has evolved to include the release of an - XAO + XAO A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons. - Wikipedia:Pectoral_girdle + Anatomical cluster of paired dermal and endochondral bones that attaches to the dorso-posterior part of the cranium, and support the radials and pectoral fin. It consists of two components: the primary pectoral girdle consisting of the endochondral coracoid, scapula and mesocoracoid bones, and the secondary pectoral girdle consisting of the dermal posttemporal, supracleithrum, cleithrum and poscleithrum(thra) bones.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000407 - TAO - TAO:wd + TAO + TAO:wd Girdle skeleton consisting of a set of bones linking the axial series to the forelimb/fin skeleton and offering anchoring areas for forelimb/fin and caudal musculature.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000156 - VSAO - https://orcid.org/0000-0002-6601-2165 + VSAO + Skeletal structure immediately behind the head attached to the vertebral column by muscles and supporting the forelimbs.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000422 - AAO - AAO:LAP + AAO + AAO:LAP The pectoral girdle is clearly of dual origin, composed of dermal as well as endochondral bones. The endochondral component, the scapulocoracoid, evolved by fusion or enlargment of several basal fin elements. (...) The dermal component of the shoulder girdle evolved from dermal bones of the body's surface. (...) Like endochondral bones, these dermal bones were passed along to tetrapods (...).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001156 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.336 and Figure 9.18 - http://bgee.unil.ch/ Note that the VSAO and many ontologies use the label 'pectoral girdle' to denote the skeletal region specifically. - VSAO + VSAO @@ -344317,19 +161312,19 @@ The modern definition of neurosecretion has evolved to include the release of an skeletal parts of pectoral girdle - https://orcid.org/0000-0002-6601-2165 + skeleton of pectoral girdle - https://orcid.org/0000-0002-6601-2165 + cingulum pectorale - Wikipedia:Pectoral_girdle + @@ -344399,6 +161394,8 @@ The modern definition of neurosecretion has evolved to include the release of an Girdle skeleton consisting of a set of bones linking the axial series to the hindlimb/fin skeleton and offering anchoring areas for hindlimb/fin and caudal musculature.[VSAO] The pelvic girdle is never joined by contributions of dermal bone. From its first appearance in placoderms, the pelvic girdle is exclusively endoskeletal. It arose from pterygiophores, perhaps several times, in support of the fin.[well established][VHOG] Note that the VSAO and many ontologies use the label 'pelvic girdle' to denote the skeletal region specifically. We place the EHDAA2 class here, note that this includes the pre-cartilage condensation as parts + + AAO:0000426 AAO:0000768 EFO:0000947 @@ -344412,11 +161409,9 @@ The modern definition of neurosecretion has evolved to include the release of an TAO:0000565 VHOG:0000305 VSAO:0000155 - Wikipedia:Pelvis XAO:0003064 ZFA:0000565 galen:PelvicGirdle - http://people.eku.edu/ritchisong/pectoralgirdles.gif pelvic girdle skeleton skeletal parts of pelvic girdle skeleton of pelvic girdle @@ -344426,7 +161421,7 @@ The modern definition of neurosecretion has evolved to include the release of an pelvic girdle skeleton - http://upload.wikimedia.org/wikipedia/commons/f/fe/Gray242.png + http://upload.wikimedia.org/wikipedia/commons/f/fe/Gray242.png @@ -344437,57 +161432,57 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:21455939 + Skeletal subdivision consisting of a set of bones linking the axial series to the hindlimb zeugopodium and offering anchoring areas for hindlimb and caudal musculature. + VSAO:0000155 - Wikipedia:Pelvis Anatomical cluster by which the hind limbs are supported and attached to the vertebral column.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000426 - AAO - AAO:LAP + AAO + AAO:LAP Anatomical cluster that consists of the paired basipterygia which support the pelvic fin.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000565 - TAO - TAO:wd + TAO + TAO:wd Girdle skeleton consisting of a set of bones linking the axial series to the hindlimb/fin skeleton and offering anchoring areas for hindlimb/fin and caudal musculature.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000155 - VSAO - https://orcid.org/0000-0002-6601-2165 + VSAO + The pelvic girdle is never joined by contributions of dermal bone. From its first appearance in placoderms, the pelvic girdle is exclusively endoskeletal. It arose from pterygiophores, perhaps several times, in support of the fin.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000305 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.333 - http://bgee.unil.ch/ Note that the VSAO and many ontologies use the label 'pelvic girdle' to denote the skeletal region specifically. We place the EHDAA2 class here, note that this includes the pre-cartilage condensation as parts - VSAO + VSAO @@ -344499,13 +161494,13 @@ The modern definition of neurosecretion has evolved to include the release of an skeletal parts of pelvic girdle - https://orcid.org/0000-0002-6601-2165 + skeleton of pelvic girdle - https://orcid.org/0000-0002-6601-2165 + @@ -344545,42 +161540,42 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO Bone element that arises as a result of intramembranous ossification. - GO_REF:0000034 + + + GO_REF:0000034 VSAO:0000023 - http://dx.plos.org/10.1371/journal.pone.0051070 - https://github.com/obophenotype/uberon/issues/267 Bone element that arises as a result of intramembranous ossification.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000023 - VSAO + VSAO GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 - PSPUB:0000170 + PSPUB:0000170 Intramembranous bone that forms deep in the organism.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001645 - TAO - TAO:wd + TAO + TAO:wd membrane bones ZFA:0001636 - + @@ -344599,6 +161594,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -344641,7 +161637,7 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO @@ -344652,7 +161648,7 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO @@ -344663,16 +161659,16 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO Skeletal element that is composed of cartilage tissue and may be permanent or transient. - GO_REF:0000034 - PSPUB:0000170 + + GO_REF:0000034 + PSPUB:0000170 VSAO:0000000 - http://dx.plos.org/10.1371/journal.pone.0051070 @@ -344690,7 +161686,7 @@ The modern definition of neurosecretion has evolved to include the release of an cartilaginous element - https://orcid.org/0000-0002-6601-2165 + @@ -344710,7 +161706,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -344742,7 +161738,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -344788,12 +161784,13 @@ The modern definition of neurosecretion has evolved to include the release of an Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts). Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts).[VSAO] Regular connective tissue, the intercellular matrix of which consists predominantly of collagen fiber bundles arranged in parallel arrays.[FMA] + + + FMA:64781 NCIT:C33453 - SCTID:22560007 UMLS:C0225333 VSAO:0000050 - Wikipedia:Dense_regular_connective_tissue XAO:0004030 dense fibrous connective tissue dense regular collagenous connective tissue @@ -344808,32 +161805,32 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA - ncithesaurus + ncithesaurus Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts). - GO_REF:0000034 - PSPUB:0000170 + + GO_REF:0000034 + PSPUB:0000170 VSAO:0000050 - http://dx.plos.org/10.1371/journal.pone.0051070 Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts).[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000050 - VSAO + VSAO GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 - PSPUB:0000170 + PSPUB:0000170 @@ -344841,7 +161838,7 @@ The modern definition of neurosecretion has evolved to include the release of an Regular connective tissue, the intercellular matrix of which consists predominantly of collagen fiber bundles arranged in parallel arrays.[FMA] 2012-08-29 FMA:64781 - FMA + FMA @@ -344910,7 +161907,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -344921,19 +161918,19 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA A bone that is part of a craniocervical region. - OBOL:automatic + OBOL:automatic EMAPA:37245 - MA:th + MA:th @@ -344949,11 +161946,12 @@ The modern definition of neurosecretion has evolved to include the release of an The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid. + + + FMA:7477 NCIT:C32881 - SCTID:421560006 UMLS:C0502414 - Wikipedia:Irregular_bone os irregulare uberon os irregulare @@ -344964,13 +161962,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid. - Wikipedia:Irregular_bone + @@ -344982,7 +161980,7 @@ The modern definition of neurosecretion has evolved to include the release of an os irregulare - Wikipedia:Irregular_bone + @@ -345033,19 +162031,19 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA A skeletal joint that is part of a appendage girdle region. - OBOL:automatic + OBOL:automatic girdle joint - OBOL:automatic + OBOL:automatic @@ -345064,6 +162062,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -345088,7 +162087,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical surface that is part of a cartilage element. - OBOL:automatic + OBOL:automatic @@ -345123,9 +162122,9 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD]. subclasses of this should be checked for taxonomic consistency Skeletal pneumaticity is the presence of air spaces within bones. Skeletal pneumaticity exists only in synapsids and archosaurs. It is generally produced during development by excavation of bone by pneumatic diverticula (air sacs) from an air-filled space such as the lungs or nasal cavity. Pneumatization is highly variable between individuals, and bones not normally pneumatized can become pneumatized in pathological development. Pneumatization occurs in the skulls of mammals, crocodilians and birds among extant groups, as well as extinct archosaurs including the dinosaurs and pterosaurs. Pneumatic spaces include the paranasal sinuses and some of the mastoid cells[WP]. [Wikipedia:Skeletal_pneumaticity] + + FMA:7478 - SCTID:333008005 - Wikipedia:Skeletal_pneumaticity galen:PneumaticBone os pneumaticum pneumatic bone @@ -345138,7 +162137,7 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD]. - http://www.medilexicon.com/medicaldictionary.php?t=11303 + @@ -345197,13 +162196,13 @@ The modern definition of neurosecretion has evolved to include the release of an Any muscle organ that is part of a pectoral girdle region. - OBOL:automatic + OBOL:automatic EMAPA has both non-skeletal and skeletal types, with the non-skeletal also including a chest muscle, so we place the skeletal class here as the most accurate - EMAPA + EMAPA @@ -345238,6 +162237,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -345264,29 +162264,29 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the ventral body cavity that is within the pelvis. + + EMAPA:37235 FMA:9738 MA:0003089 - SCTID:281903009 - Wikipedia:Pelvic_cavity space of pelvic compartment uberon cavitas pelvis UBERON:0008203 pelvic cavity - http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg + http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg The part of the ventral body cavity that is within the pelvis. - UBERON:cjm + UBERON:cjm EMAPA:37235 - MA:th + MA:th @@ -345298,7 +162298,7 @@ The modern definition of neurosecretion has evolved to include the release of an cavitas pelvis - Wikipedia:Pelvic_cavity + @@ -345342,7 +162342,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -345353,7 +162353,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -345366,13 +162366,13 @@ The modern definition of neurosecretion has evolved to include the release of an in MA this is restricted to skeletal muscles - MA + MA EMAPA:37259 - MA:th + MA:th @@ -345405,6 +162405,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + @@ -345412,10 +162418,10 @@ The modern definition of neurosecretion has evolved to include the release of an Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax. + EMAPA:37234 FMA:24217 MA:0000028 - SCTID:362666008 dorsum of thorax posterior part of thorax thoracic back @@ -345435,8 +162441,18 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA - MA + FMA + + + + + + + + + + + MA @@ -345447,7 +162463,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -345459,7 +162475,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37234 - MA:th + MA:th @@ -345523,9 +162539,9 @@ The modern definition of neurosecretion has evolved to include the release of an A muscle of back that is part of a dorsal thoracic segment of trunk. + EMAPA:37261 MA:0000508 - SCTID:305071003 uberon UBERON:0008243 upper back muscle @@ -345534,7 +162550,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -345545,19 +162561,19 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA A muscle of back that is part of a dorsal thoracic segment of trunk. - OBOL:automatic + OBOL:automatic EMAPA:37261 - MA:th + MA:th @@ -345595,7 +162611,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelium that is part of a heart [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -345638,7 +162654,7 @@ The modern definition of neurosecretion has evolved to include the release of an - BTO + BTO @@ -345680,7 +162696,7 @@ The modern definition of neurosecretion has evolved to include the release of an An intestinal villus in the duodenum. - OBOL:automatic + OBOL:automatic @@ -345714,11 +162730,11 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a duodenum. + CALOHA:TS-2087 EMAPA:19078 FMA:17231 MA:0003208 - SCTID:66036002 epithelium of duodenum uberon UBERON:0008346 @@ -345734,13 +162750,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA An epithelium that is part of a duodenum. - OBOL:automatic + OBOL:automatic @@ -345751,6 +162767,50 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + Epithelium pertaining to the trachea and bronchi. + BTO:0002925 + CALOHA:TS-1063 + uberon + bronchotracheal epithelium + UBERON:0008397 + tracheobronchial epithelium + + + + + Epithelium pertaining to the trachea and bronchi. + Dorlands_Medical_Dictionary:MerckMedicus + + + + + bronchotracheal epithelium + BTO:0002925 + + + + @@ -345774,8 +162834,8 @@ The modern definition of neurosecretion has evolved to include the release of an A vertebral foramen that is part of a cervical vertebra. + FMA:13480 - SCTID:280833008 uberon UBERON:0008429 cervical vertebral foramen @@ -345784,7 +162844,7 @@ The modern definition of neurosecretion has evolved to include the release of an A vertebral foramen that is part of a cervical vertebra. - OBOL:automatic + OBOL:automatic @@ -345812,8 +162872,8 @@ The modern definition of neurosecretion has evolved to include the release of an A vertebral foramen that is part of a thoracic vertebra. + FMA:9143 - SCTID:280834002 uberon UBERON:0008432 thoracic vertebral foramen @@ -345822,7 +162882,7 @@ The modern definition of neurosecretion has evolved to include the release of an A vertebral foramen that is part of a thoracic vertebra. - OBOL:automatic + OBOL:automatic @@ -345841,6 +162901,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -345855,6 +162916,7 @@ The modern definition of neurosecretion has evolved to include the release of an An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers. + EHDAA2:0000444 EHDAA:42 EHDAA:75 @@ -345878,7 +162940,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia @@ -345904,7 +162966,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + + @@ -345925,6 +162988,7 @@ The modern definition of neurosecretion has evolved to include the release of an A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]. Currently defined in a vertebrate specific manner. The arch system has origins in basal deuterostomes, consider generalizing + EHDAA2:0000187 FMA:293041 NCIT:C34248 @@ -345945,7 +163009,7 @@ The modern definition of neurosecretion has evolved to include the release of an A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]. GO:0060037 - GOC:dph + GOC:dph @@ -346002,7 +163066,7 @@ The modern definition of neurosecretion has evolved to include the release of an A head that is part of a embryo. - OBOL:automatic + OBOL:automatic @@ -346053,7 +163117,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -346064,7 +163128,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -346075,14 +163139,14 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional A brain that develops_from a neural tube. - OBOL:automatic - https://github.com/obophenotype/uberon/issues/338 + + OBOL:automatic @@ -346122,12 +163186,13 @@ The modern definition of neurosecretion has evolved to include the release of an An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts. in mice, the hepatic diverticulum forms by E9 and expands into an obvious liver bud by E10 The caudal part of the septum transversum is invaded by the hepatic diverticulum which divides within it to form the liver and thus gives rise to the ventral mesentery of the foregut. + + AAO:0011057 EHDAA2:0000740 EHDAA:1530 NCIT:C34187 UMLS:C1512407 - Wikipedia:Hepatic_diverticulum XAO:0000101 liver diverticulum uberon @@ -346135,13 +163200,13 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0008835 hepatic diverticulum - http://upload.wikimedia.org/wikipedia/commons/4/4f/Gray1088.png + http://upload.wikimedia.org/wikipedia/commons/4/4f/Gray1088.png - EHDAA2 + EHDAA2 @@ -346153,7 +163218,7 @@ The modern definition of neurosecretion has evolved to include the release of an caudal part - EHDAA2 + EHDAA2 @@ -346164,7 +163229,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -346175,14 +163240,14 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts. - MP:MP - http://www.stembook.org/node/512 + + MP:MP @@ -346200,7 +163265,7 @@ The modern definition of neurosecretion has evolved to include the release of an diverticulum hepaticum - Wikipedia:Hepatic_diverticulum + @@ -346234,7 +163299,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -346245,7 +163310,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -346256,65 +163321,7 @@ The modern definition of neurosecretion has evolved to include the release of an - http://www.stembook.org/node/512 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity[MP]. a developmental cavity that exists in some mammals and is derived by division of the proamniotic space; it is further removed from the embryo than the amniotic cavity in some mammals. - EMAPA:16080 - epamniotic cavity - uberon - epamniotic cavity - UBERON:0008851 - - ectoplacental cavity - - - - - Closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity[MP]. a developmental cavity that exists in some mammals and is derived by division of the proamniotic space; it is further removed from the embryo than the amniotic cavity in some mammals. - MP:0011207 - http://www.medilexicon.com/medicaldictionary.php?s=epamniotic+cavity - - - - - epamniotic cavity - http://www.medilexicon.com/medicaldictionary.php?s=epamniotic+cavity - - - - - epamniotic cavity - MP:0011207 + @@ -346368,8 +163375,8 @@ The modern definition of neurosecretion has evolved to include the release of an The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines. the muscularis externa in the stomach differs from that of other GI organs in that it has three layers of smooth muscle instead of two + FMA:14909 - SCTID:362132003 gastric muscularis muscle layer of stomach muscularis externa of stomach @@ -346389,7 +163396,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -346412,7 +163419,7 @@ The modern definition of neurosecretion has evolved to include the release of an the muscularis externa in the stomach differs from that of other GI organs in that it has three layers of smooth muscle instead of two - WP + WP @@ -346470,23 +163477,23 @@ The modern definition of neurosecretion has evolved to include the release of an The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter. + + EMAPA:37944 FMA:14580 - SCTID:245417002 - Wikipedia:Pyloric_canal canalis pyloricus uberon canalis pyloricus UBERON:0008858 pyloric canal - https://upload.wikimedia.org/wikipedia/commons/3/33/Illu_stomach.jpg + https://upload.wikimedia.org/wikipedia/commons/3/33/Illu_stomach.jpg - FMA + FMA @@ -346497,32 +163504,32 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter. + MP:0010791 - Wikipedia:Pyloric_canal EMAPA:37944 - MA:th + MA:th canalis pyloricus - Wikipedia:Pyloric_canal + canalis pyloricus - Wikipedia:Pyloric_canal + @@ -346576,12 +163583,13 @@ The modern definition of neurosecretion has evolved to include the release of an The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP]. check relationship to pylorus vs antrum + + + EMAPA:27211 FMA:14922 NCIT:C33431 - SCTID:70710007 UMLS:C0227239 - Wikipedia:Pyloric_gland glandula pylorica pyloric antrum gland pyloric gland @@ -346590,13 +163598,13 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0008861 pyloric gastric gland - http://upload.wikimedia.org/wikipedia/commons/b/bf/Gray1054.png + http://upload.wikimedia.org/wikipedia/commons/b/bf/Gray1054.png - MP + MP @@ -346607,7 +163615,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ISBN:0073040584 + ISBN:0073040584 @@ -346618,14 +163626,14 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia:Tubular_gland + The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP]. + MP:0010797 - Wikipedia:Pyloric_gland @@ -346643,7 +163651,7 @@ The modern definition of neurosecretion has evolved to include the release of an pyloric antrum gland - OBOL:automatic + OBOL:automatic @@ -346671,6 +163679,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + @@ -346730,7 +163744,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any skeletal muscle organ in the hypodermis / superficial fascia. - ISBN:0123813611 + ISBN:0123813611 MP:0011157 @@ -346757,8 +163771,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -346780,8 +163794,8 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins. Subdivision of cardiovascular system which has as its parts the pulmonary arterial and venous tree organs.[FMA] + FMA:45621 - Wikipedia:Pulmonary_circulation pulmonary circulatory system pulmonary system uberon @@ -346793,7 +163807,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Obol + Obol @@ -346804,20 +163818,20 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins. - ISBN:0073040584 - Wikipedia:Pulmonary_circulation + + ISBN:0073040584 Subdivision of cardiovascular system which has as its parts the pulmonary arterial and venous tree organs.[FMA] - FMA + FMA FMA:45621 @@ -346830,7 +163844,7 @@ The modern definition of neurosecretion has evolved to include the release of an pulmonary system - ISBN:0073040584 + ISBN:0073040584 @@ -346838,6 +163852,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -346853,18 +163868,17 @@ The modern definition of neurosecretion has evolved to include the release of an Subdivision of endoskeleton derived from pharyngeal arches. - Anatomical cluster that is part of the cranium and consists of the jaws, hyoid and branchial arches.[TAO] Anatomical cluster that is part of the cranium and consists of the jaws, hyoid, and branchial arches.[AAO] The part of the skull derived from the embryonic pharyngeal arches. [Biology_Online][VHOG] The skull of ancestral tetrapods has the three basic components that we have been considering: (1) chondrocranium, (2) splanchnocranium, and (3) dermatocranium (reference 1); Each part of the skull arises from a separate phylogenetic source. The most ancient part is the splanchnocranium (visceral cranium), which first arose to support pharyngeal slits in protochordates (reference 2).[well established][VHOG] VSAO labels this term 'pharyngeal arch' (2012-06-01) - however, it clearly means pharyngeal arch skeleton. many sources define this as the part of the endoskeletal that is from pharyngeal arches - this would make it part-disjoint from dermatocranium. However, there are many bones in AOs that have part-paths to both + AAO:0010157 TAO:0001216 VHOG:0000315 VSAO:0000149 - Wikipedia:Facial_skeleton XAO:0003176 ZFA:0001216 pharyngeal endoskeleton @@ -346879,9 +163893,8 @@ The modern definition of neurosecretion has evolved to include the release of an visceral skeletal system visceral skeleton UBERON:0008895 - splanchnocranium - http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg + http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg @@ -346892,7 +163905,7 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/issues/83 + @@ -346904,53 +163917,53 @@ The modern definition of neurosecretion has evolved to include the release of an redundant + Grays - PMID:11237469 Subdivision of endoskeleton derived from pharyngeal arches. - ISBN:0073040584 - Wikipedia:Facial_skeleton - https://orcid.org/0000-0002-6601-2165 + + + ISBN:0073040584 Anatomical cluster that is part of the cranium and consists of the jaws, hyoid and branchial arches.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001216 - TAO - ZFIN:curator + TAO + ZFIN:curator Anatomical cluster that is part of the cranium and consists of the jaws, hyoid, and branchial arches.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010157 - AAO - AAO:EJS + AAO + AAO:EJS The part of the skull derived from the embryonic pharyngeal arches. [Biology_Online][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000315 - VHOG - http://bgee.unil.ch/ + VHOG + The skull of ancestral tetrapods has the three basic components that we have been considering: (1) chondrocranium, (2) splanchnocranium, and (3) dermatocranium (reference 1); Each part of the skull arises from a separate phylogenetic source. The most ancient part is the splanchnocranium (visceral cranium), which first arose to support pharyngeal slits in protochordates (reference 2).[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000315 - VHOG + VHOG + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.242, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.235 - http://bgee.unil.ch/ @@ -346962,14 +163975,14 @@ The modern definition of neurosecretion has evolved to include the release of an pharyngeal endoskeleton - http://orcid.org/0000-0002-6601-2165 + viscerocranium + VHOG:0000315 - Wikipedia:Viscerocranium ZFA:0001216 @@ -346996,13 +164009,13 @@ The modern definition of neurosecretion has evolved to include the release of an visceral cranium - http://orcid.org/0000-0002-6601-2165 + visceral skeletal system - http://orcid.org/0000-0002-6601-2165 + @@ -347038,10 +164051,10 @@ The modern definition of neurosecretion has evolved to include the release of an Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO]. Intramembranous bone that forms superficially in the organism.[TAO] other AOs are not yet in sync with this classification + AAO:0010769 TAO:0001590 VSAO:0000130 - Wikipedia:Dermal_bone XAO:0004015 ZFA:0001590 uberon @@ -347059,7 +164072,7 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO @@ -347070,32 +164083,32 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO]. - GO_REF:0000034 + + + GO_REF:0000034 VSAO:0000130 - http://dx.plos.org/10.1371/journal.pone.0051070 - https://github.com/obophenotype/uberon/issues/267 Intramembranous bone that forms superficially in the organism.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001590 - TAO - TAO:wd + TAO + TAO:wd dermal bones ZFA:0001590 - + @@ -347139,31 +164152,31 @@ The modern definition of neurosecretion has evolved to include the release of an not in VSAO - ZFA + ZFA Bone element that is adjacent to the notochord. - GO_REF:0000034 + + GO_REF:0000034 VSAO:0000307 - http://dx.plos.org/10.1371/journal.pone.0051070 Replacement bone that forms within the connective tissue surrounding the notochord.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001639 - TAO - TAO:wd + TAO + TAO:wd perichordal bones ZFA:0001629 - + @@ -347197,10 +164210,10 @@ The modern definition of neurosecretion has evolved to include the release of an A parenchyma that is part of a lung. + EMAPA:35522 FMA:27360 MA:0003168 - SCTID:201712001 respiratory portion of lung uberon parenchyma of lung @@ -347212,7 +164225,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -347223,13 +164236,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A parenchyma that is part of a lung. - OBOL:automatic + OBOL:automatic @@ -347256,6 +164269,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -347268,6 +164282,7 @@ The modern definition of neurosecretion has evolved to include the release of an + EHDAA2:0004069 NCIT:C34283 UMLS:C1514898 @@ -347279,7 +164294,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Obol + Obol @@ -347290,60 +164305,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - A lobe of lung that is part of a left lung. - 1 in mice, divided into 2 in human by a single interlobar fissure, the oblqiue fissure - EHDAA:2981 - NCIT:C48945 - SCTID:272655003 - UMLS:C1285107 - lobe of left lung - lobe of the left lung - uberon - UBERON:0008951 - left lung lobe - - - - - A lobe of lung that is part of a left lung. - OBOL:automatic - - - - - 1 in mice, divided into 2 in human by a single interlobar fissure, the oblqiue fissure - ISBN:0123813611 - - - - - UMLS:C1285107 - ncithesaurus:Lobe_of_the_Left_Lung - - - - @@ -347386,12 +164347,13 @@ The modern definition of neurosecretion has evolved to include the release of an One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed. + + + BTO:0003634 FMA:9404 NCIT:C32536 - SCTID:322749003 UMLS:C0227178 - Wikipedia:Esophageal_glands esophageal gland glandulae oesophageae mucous gland of submucosa of esophagus @@ -347399,14 +164361,14 @@ The modern definition of neurosecretion has evolved to include the release of an submocosal esophageal gland UBERON:0008989 submucosal esophageal gland - http://upload.wikimedia.org/wikipedia/commons/e/e8/Illu_esophageal_layers.jpg + http://upload.wikimedia.org/wikipedia/commons/e/e8/Illu_esophageal_layers.jpg One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed. + BTO:0003634 - Wikipedia:Esophageal_glands @@ -347424,7 +164386,7 @@ The modern definition of neurosecretion has evolved to include the release of an glandulae oesophageae - Wikipedia:Esophageal_glands + @@ -347448,12 +164410,12 @@ The modern definition of neurosecretion has evolved to include the release of an System pertaining to blood vessels in the brain. UBERON:0005284 + BTO:0003840 EFO:0003491 EMAPA:35186 FMA:242007 FMA:61935 - SCTID:362029003 TAO:0000099 ZFA:0000099 brain vasculature @@ -347508,9 +164470,9 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a dorsal thoracic segment of trunk. + EMAPA:37280 MA:0000510 - SCTID:304890003 uberon UBERON:0009015 upper back skin @@ -347519,19 +164481,19 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA A zone of skin that is part of a dorsal thoracic segment of trunk. - OBOL:automatic + OBOL:automatic EMAPA:37280 - MA:th + MA:th @@ -347559,10 +164521,11 @@ The modern definition of neurosecretion has evolved to include the release of an Vein that drains left lung and returns blood to the heart. A vein that returns oxygenated blood from the left lung to the left atrium of the heart[ncithesaurus:Left_Pulmonary_Vein]. + + EMAPA:37165 MA:0002207 NCIT:C48946 - SCTID:304057004 UMLS:C0226670 uberon UBERON:0009030 @@ -347572,7 +164535,7 @@ The modern definition of neurosecretion has evolved to include the release of an Vein that drains left lung and returns blood to the heart. - http://orcid.org/0000-0002-6601-2165 + @@ -347584,7 +164547,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37165 - MA:th + MA:th @@ -347618,10 +164581,11 @@ The modern definition of neurosecretion has evolved to include the release of an Vein that drains right lung and returns blood to the heart. A vein that returns oxygenated blood from the right lung to the left atrium of the heart[ncithesaurus:Right_Pulmonary_Vein]. + + EMAPA:37379 MA:0002208 NCIT:C48947 - SCTID:304056008 UMLS:C0226669 uberon UBERON:0009032 @@ -347631,7 +164595,7 @@ The modern definition of neurosecretion has evolved to include the release of an Vein that drains right lung and returns blood to the heart. - http://orcid.org/0000-0002-6601-2165 + @@ -347643,7 +164607,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37379 - MA:th + MA:th @@ -347665,6 +164629,7 @@ The modern definition of neurosecretion has evolved to include the release of an A gonad prior to differentiating into a definitive testis or ovary. + EHDAA2:0000716 NCIT:C34192 UMLS:C1512703 @@ -347679,7 +164644,7 @@ The modern definition of neurosecretion has evolved to include the release of an A gonad prior to differentiating into a definitive testis or ovary. - http://www.medterms.com/script/main/art.asp?articlekey=8981 + @@ -347713,7 +164678,6 @@ The modern definition of neurosecretion has evolved to include the release of an Cranial ganglion which develops from an epibranchial placode. - BTO:0006250 TAO:0001555 ZFA:0001555 epibranchial ganglia @@ -347726,7 +164690,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -347743,21 +164707,15 @@ The modern definition of neurosecretion has evolved to include the release of an Cranial ganglion which develops from an epibranchial placode. - PMID:20133851 - ZFIN:curator - - - - - BTO:0006250 - https://orcid.org/0000-0003-4423-4370 + + ZFIN:curator epibranchial ganglia ZFA:0001555 - + @@ -347780,6 +164738,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -347800,10 +164759,10 @@ The modern definition of neurosecretion has evolved to include the release of an Endocardium that is part of the right atrium. + EHDAA2:0000274 FMA:7281 NCIT:C102339 - SCTID:3194006 VHOG:0001228 endocardium of right atrium right atrial endocardium @@ -347816,7 +164775,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -347827,7 +164786,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -347838,13 +164797,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Endocardium that is part of the right atrium. - http://orcid.org/0000-0002-6601-2165 + @@ -347888,13 +164847,14 @@ The modern definition of neurosecretion has evolved to include the release of an A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities. In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart [of other tetrapods] is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG] UBERON:0009146 + + + EHDAA2:0001483 EMAPA:17709 NCIT:C34256 - SCTID:361429005 UMLS:C1283968 VHOG:0000757 - Wikipedia:Pleuroperitoneal pleuroperitoneal fold pleuroperitoneal membranes uberon @@ -347905,30 +164865,30 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 - EHDAA2 + EHDAA2 A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities. - Wikipedia:Pleuroperitoneal - http://medical-dictionary.thefreedictionary.com/pleuroperitoneal+membrane + + In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart [of other tetrapods] is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000757 - VHOG + VHOG + ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206 - http://bgee.unil.ch/ @@ -347947,7 +164907,7 @@ The modern definition of neurosecretion has evolved to include the release of an pleuroperitoneal membranes EHDAA2:0001483 - + @@ -347980,8 +164940,8 @@ The modern definition of neurosecretion has evolved to include the release of an A vein that is part of a craniocervical region. + EHDAA2:0004542 - SCTID:32945007 craniocervical vein head and neck veins vein of head and neck @@ -347998,13 +164958,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 A vein that is part of a craniocervical region. - OBOL:automatic + OBOL:automatic @@ -348018,7 +164978,9 @@ The modern definition of neurosecretion has evolved to include the release of an + + @@ -348056,13 +165018,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Sum total of mesenchyme in the embryo. - https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/7 + @@ -348070,6 +165032,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -348093,7 +165056,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -348158,13 +165121,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 - EHDAA2 + EHDAA2 @@ -348175,7 +165138,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -348186,13 +165149,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 A sphenoid endochondral element that is composed primarily of a pre-cartilage condensation. - OBOL:automatic + OBOL:automatic @@ -348245,7 +165208,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -348256,13 +165219,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 A sphenoid endochondral element that is composed primarily of cartilage tissue. - OBOL:automatic + OBOL:automatic @@ -348293,7 +165256,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -348338,7 +165301,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -348349,7 +165312,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -348360,13 +165323,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that is part of a medial nasal prominence. - OBOL:automatic + OBOL:automatic @@ -348376,11 +165339,11 @@ The modern definition of neurosecretion has evolved to include the release of an medial or lateral; in EHDAA2 also frontonasal or intermaxillary + EHDAA2:0000581 EHDAA:4776 EMAPA:16680 FMA:293971 - SCTID:308881001 uberon nasal placode UBERON:0009292 @@ -348390,7 +165353,7 @@ The modern definition of neurosecretion has evolved to include the release of an medial or lateral; in EHDAA2 also frontonasal or intermaxillary - EHDAA2 + EHDAA2 @@ -348428,7 +165391,7 @@ The modern definition of neurosecretion has evolved to include the release of an An ectoderm that is part of a buccopharyngeal membrane. - OBOL:automatic + OBOL:automatic @@ -348466,7 +165429,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endoderm that is part of a buccopharyngeal membrane. - OBOL:automatic + OBOL:automatic @@ -348485,6 +165448,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -348504,7 +165468,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a foregut-midgut junction. - OBOL:automatic + OBOL:automatic @@ -348545,17 +165509,17 @@ The modern definition of neurosecretion has evolved to include the release of an A mesentery that is part of a foregut-midgut junction. - OBOL:automatic + OBOL:automatic Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000430 - VHOG + VHOG + ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11 - http://bgee.unil.ch/ @@ -348582,6 +165546,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -348615,7 +165580,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -348626,13 +165591,13 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm A portion of mesenchymal tissue associated with an individual pharyngeal arch. - https://orcid.org/0000-0002-6601-2165 + @@ -348650,7 +165615,7 @@ The modern definition of neurosecretion has evolved to include the release of an pharyngeal arch mesenchyme - https://orcid.org/0000-0002-6601-2165 + @@ -348707,7 +165672,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -348718,13 +165683,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 An epithelium that is part of a foregut-midgut junction. - OBOL:automatic + OBOL:automatic @@ -348803,6 +165768,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -348823,7 +165789,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a developing hindgut. - OBOL:automatic + OBOL:automatic @@ -348834,6 +165800,65 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a developing trachea. + EHDAA2:0002067 + EMAPA:16854 + trachea associated mesenchyme + uberon + UBERON:0009505 + + mesenchyme of trachea + + + + + + EHDAA2 + + + + + Mesenchyme that is part of a developing trachea. + OBOL:automatic + + + + + trachea associated mesenchyme + EHDAA2:0002067 + + + + @@ -348878,7 +165903,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endoderm that is part of a anal region. - OBOL:automatic + OBOL:automatic @@ -348899,6 +165924,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -348920,7 +165946,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a maxillary prominence. - OBOL:automatic + OBOL:automatic @@ -348932,7 +165958,7 @@ The modern definition of neurosecretion has evolved to include the release of an mesenchyme of maxillary prominence - https://orcid.org/0000-0002-6601-2165 + @@ -348978,7 +166004,7 @@ The modern definition of neurosecretion has evolved to include the release of an A hepatic sinusoid that is part of a left lobe of liver. - OBOL:automatic + OBOL:automatic @@ -349030,7 +166056,7 @@ The modern definition of neurosecretion has evolved to include the release of an A hepatic sinusoid that is part of a right lobe of liver. - OBOL:automatic + OBOL:automatic @@ -349074,7 +166100,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endoderm that is part of a foregut-midgut junction. - OBOL:automatic + OBOL:automatic @@ -349122,13 +166148,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A submucosa that is part of a intestine. - OBOL:automatic + OBOL:automatic @@ -349172,10 +166198,10 @@ The modern definition of neurosecretion has evolved to include the release of an Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions. Region of the vertebral column between the atlas and the sacrum consisting of seven to 285 vertebrae.[AAO] + AAO:0000612 FMA:72066 NCIT:C92597 - SCTID:281699004 thoracolumbar column thoracolumbar region of vertebral column thoracolumbar vertebrae set @@ -349202,9 +166228,9 @@ The modern definition of neurosecretion has evolved to include the release of an Region of the vertebral column between the atlas and the sacrum consisting of seven to 285 vertebrae.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000612 - AAO + AAO AAO:Duellman_and_Trueb_1994 @@ -349244,8 +166270,8 @@ The modern definition of neurosecretion has evolved to include the release of an + FMA:25054 - SCTID:22943007 region of trunk trunk subdivision uberon @@ -349302,7 +166328,7 @@ The modern definition of neurosecretion has evolved to include the release of an A sulcus limitans of neural tube that is part of a future spinal cord. - OBOL:automatic + OBOL:automatic @@ -349328,6 +166354,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -349356,13 +166383,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 A sulcus limitans of neural tube that is part of a future medulla oblongata. - OBOL:automatic + OBOL:automatic @@ -349382,6 +166409,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -349399,7 +166427,7 @@ The modern definition of neurosecretion has evolved to include the release of an A sulcus limitans of neural tube that is part of a future metencephalon. - OBOL:automatic + OBOL:automatic @@ -349419,6 +166447,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -349435,7 +166464,7 @@ The modern definition of neurosecretion has evolved to include the release of an A sulcus limitans of neural tube that is part of a future myelencephalon. - OBOL:automatic + OBOL:automatic @@ -349566,19 +166595,19 @@ The modern definition of neurosecretion has evolved to include the release of an - EMAPA + EMAPA Mesenchyme that is part of a 1st arch mandibular component. - OBOL:automatic + OBOL:automatic mesenchymal region of mandibular component of first pharyngeal arch - https://orcid.org/0000-0002-6601-2165 + @@ -349623,7 +166652,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a developing left lung. - OBOL:automatic + OBOL:automatic @@ -349667,7 +166696,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a developing right lung. - OBOL:automatic + OBOL:automatic @@ -349726,7 +166755,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -349737,13 +166766,13 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA A neural plate that develops_from a presumptive midbrain. - OBOL:automatic + OBOL:automatic @@ -349763,6 +166792,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -349796,7 +166826,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -349807,13 +166837,13 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA A neural plate that develops_from a presumptive hindbrain. - OBOL:automatic + OBOL:automatic @@ -349858,7 +166888,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -349870,13 +166900,13 @@ The modern definition of neurosecretion has evolved to include the release of an https://github.com/obophenotype/uberon/issues/438 - Bgee:AN + Bgee:AN MHB neural plate - https://orcid.org/0000-0002-6601-2165 + @@ -349928,12 +166958,12 @@ The modern definition of neurosecretion has evolved to include the release of an A presumptive structure that has the potential to develop into a midbrain. TODO - unify naming conventions + BAMS:MES EFO:0003432 EHDAA2:0000615 EMAPA:16140 TAO:0000148 - Wikipedia:Mesencephalon ZFA:0000148 presumptive mesencephalon uberon @@ -349953,7 +166983,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -349964,13 +166994,13 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA A presumptive structure that has the potential to develop into a midbrain. - OBOL:automatic + OBOL:automatic @@ -349982,13 +167012,13 @@ The modern definition of neurosecretion has evolved to include the release of an early midbrain - https://orcid.org/0000-0002-6601-2165 + future midbrain - https://orcid.org/0000-0002-6601-2165 + @@ -350002,6 +167032,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -350040,44 +167071,44 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles. - PMID:21610022 + cephalic paraxial mesenchyme - https://orcid.org/0000-0002-6601-2165 + cephalic paraxial mesoderm - https://orcid.org/0000-0002-6601-2165 + cranial paraxial mesenchyme - https://orcid.org/0000-0002-6601-2165 + cranial paraxial mesoderm - https://orcid.org/0000-0002-6601-2165 + head paraxial mesenchyme + EHDAA2:0000736 - https://github.com/obophenotype/uberon/issues/30 @@ -350085,6 +167116,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -350114,7 +167146,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -350126,7 +167158,7 @@ The modern definition of neurosecretion has evolved to include the release of an trunk paraxial mesenchyme - https://github.com/obophenotype/uberon/issues/30 + @@ -350164,7 +167196,200 @@ The modern definition of neurosecretion has evolved to include the release of an A somite that is part of a tail. - OBOL:automatic + OBOL:automatic + + + + + + + + + EMAPA:35878 + MA:0001859 + uberon + UBERON:0009644 + trachea non-cartilage connective tissue + + + + + + MA + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A basement membrane that is part of a bronchus. + MA classifies as type of connective tissue: https://github.com/obophenotype/mouse-anatomy-ontology/issues/108 + + EMAPA:37809 + MA:0001832 + NCIT:C49208 + UMLS:C1707051 + bronchial basement membrane + uberon + UBERON:0009652 + bronchus basement membrane + + + + + + + + + + + true + + + + + + A basement membrane that is part of a bronchus. + OBOL:automatic + + + + + MA classifies as type of connective tissue: https://github.com/obophenotype/mouse-anatomy-ontology/issues/108 + MA + + + + + EMAPA:37809 + MA:th + + + + + UMLS:C1707051 + ncithesaurus:Bronchus_Basement_Membrane + + + + + bronchial basement membrane + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A basement membrane that is part of a trachea. + + EMAPA:37552 + MA:0001854 + NCIT:C49302 + UMLS:C1710455 + uberon + UBERON:0009653 + trachea basement membrane + + + + + + + + + + + true + + + + + + + + + + + + MA-modified + + + + + A basement membrane that is part of a trachea. + OBOL:automatic + + + + + EMAPA:37552 + MA:th + + + + + UMLS:C1710455 + ncithesaurus:Trachea_Basement_Membrane @@ -350197,6 +167422,7 @@ The modern definition of neurosecretion has evolved to include the release of an labial artery + EMAPA:37092 MA:0001987 NCIT:C52947 @@ -350215,7 +167441,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37092 - MA:th + MA:th @@ -350248,7 +167474,7 @@ The modern definition of neurosecretion has evolved to include the release of an Nucleus located in the midbrain. - SCTID:279285003 + TAO:0002209 ZFA:0001665 uberon @@ -350259,7 +167485,7 @@ The modern definition of neurosecretion has evolved to include the release of an Nucleus located in the midbrain. - ZFIN:curator + ZFIN:curator @@ -350296,7 +167522,7 @@ The modern definition of neurosecretion has evolved to include the release of an Nucleus located within the hindbrain. - ZFIN:curator + ZFIN:curator @@ -350330,19 +167556,19 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 peritoneal cavity mesentary - http://orcid.org/0000-0002-6601-2165 + peritoneal mesentary - http://orcid.org/0000-0002-6601-2165 + @@ -350390,7 +167616,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical space that surrounded_by a embryonic cloaca. - OBOL:automatic + OBOL:automatic @@ -350410,6 +167636,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -350435,10 +167662,10 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical space that surrounded_by a rectum. + EHDAA2:0004587 EMAPA:18388 FMA:14598 - SCTID:259740004 lumen of rectum uberon UBERON:0009670 @@ -350453,7 +167680,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -350464,13 +167691,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 An anatomical space that surrounded_by a rectum. - OBOL:automatic + OBOL:automatic @@ -350518,7 +167745,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -350529,7 +167756,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -350540,7 +167767,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -350551,7 +167778,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -350593,7 +167820,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -350604,7 +167831,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -350615,7 +167842,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -350626,7 +167853,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -350646,6 +167873,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -350666,11 +167894,11 @@ The modern definition of neurosecretion has evolved to include the release of an Any endocardium that is part of the right ventricle of the heart. Endocardium of ventricle which is continuous tricuspid valve, pulmonary valve and with the tunica intima of the pulmonary trunk. + EHDAA2:0002188 EMAPA:17341 FMA:9536 NCIT:C102343 - SCTID:8911002 VHOG:0001235 right ventricle endocardium right ventricular endocardium @@ -350689,7 +167917,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -350700,13 +167928,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Any endocardium that is part of the right ventricle of the heart. - http://orcid.org/0000-0002-6601-2165 + @@ -350770,10 +167998,10 @@ The modern definition of neurosecretion has evolved to include the release of an Any endocardium that is part of the left ventricle of the heart. Endocardium of ventricle which is continuous with mitral valve, aortic valve, atrioventricular septum and the tunica intima of the aorta. + EHDAA2:0002182 EMAPA:17338 FMA:9559 - SCTID:191004004 VHOG:0001233 left ventricle endocardium left ventricular endocardium @@ -350792,13 +168020,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Any endocardium that is part of the left ventricle of the heart. - http://orcid.org/0000-0002-6601-2165 + @@ -350848,6 +168076,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -350872,7 +168101,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical cavity that surrounded_by a stomodeum. - OBOL:automatic + OBOL:automatic @@ -350918,7 +168147,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -350929,7 +168158,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -351042,6 +168271,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -351050,7 +168280,7 @@ The modern definition of neurosecretion has evolved to include the release of an A ganglion that is part of a abdominal segment of trunk. - SCTID:280508003 + uberon UBERON:0009758 abdominal ganglion @@ -351059,7 +168289,7 @@ The modern definition of neurosecretion has evolved to include the release of an A ganglion that is part of a abdominal segment of trunk. - OBOL:automatic + OBOL:automatic @@ -351111,9 +168341,9 @@ The modern definition of neurosecretion has evolved to include the release of an A serous sac that has the pleura and the pleural cavity as parts. despite its name the class EHDAA2:0004737 is not a true cavity, it corresponds to what we call the sac + EHDAA2:0004737 FMA:9690 - SCTID:361996004 uberon UBERON:0009778 @@ -351128,7 +168358,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -351139,19 +168369,19 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA-abduced-lr + FMA-abduced-lr A serous sac that has the pleura and the pleural cavity as parts. - https://github.com/obophenotype/uberon/issues/86 + despite its name the class EHDAA2:0004737 is not a true cavity, it corresponds to what we call the sac - EHDAA2 + EHDAA2 @@ -351200,19 +168430,19 @@ The modern definition of neurosecretion has evolved to include the release of an The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form. acinar acinus + FMA:55588 - Wikipedia:Acinus uberon acini UBERON:0009842 glandular acinus - http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png + http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form. - Wikipedia:Acinus + @@ -351224,8 +168454,8 @@ The modern definition of neurosecretion has evolved to include the release of an acini - Wikipedia:Acinus - + + @@ -351277,7 +168507,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -351288,7 +168518,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -351299,13 +168529,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 An epithelium that is part of a embryonic cloaca. - OBOL:automatic + OBOL:automatic @@ -351347,7 +168577,7 @@ The modern definition of neurosecretion has evolved to include the release of an A multicellular organism that existence_starts_and_ends_during a nematode larval stage. - OBOL:automatic + OBOL:automatic @@ -351386,7 +168616,7 @@ The modern definition of neurosecretion has evolved to include the release of an Branch or outpocketing of the digestive tract. - https://orcid.org/0000-0002-6601-2165 + @@ -351453,25 +168683,25 @@ The modern definition of neurosecretion has evolved to include the release of an A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland. We follow Kardong in defining stomach regions by gland, but we also include 'body of stomach'. In future we may want to have different partitions of the stomach UBERON:0009034 + + EMAPA:35821 FMA:14558 MA:0002561 - SCTID:245415005 - Wikipedia:Stomach#Sections gastric zone region of stomach section of stomach uberon UBERON:0009870 zone of stomach - http://upload.wikimedia.org/wikipedia/commons/2/29/Regions_of_stomach.svg + http://upload.wikimedia.org/wikipedia/commons/2/29/Regions_of_stomach.svg A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland. - ISBN:0073040584 - Wikipedia:Stomach#Sections + + ISBN:0073040584 @@ -351507,7 +168737,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -351518,7 +168748,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -351593,7 +168823,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:17276708 + @@ -351604,7 +168834,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:17276708 + @@ -351618,26 +168848,26 @@ The modern definition of neurosecretion has evolved to include the release of an extra-cardiac population of mesodermal progenitors that gives rise to the right ventricle and outflow tract[PMID:17276708]. - PMID:17276708 + In general, the two studies in chick concluded that the contribution of the SHF was to the outflow tract, whereas the mouse work suggested that the second lineage contributed more broadly to the heart, including the outflow tract and much or all of the right ventricle [11-14]. These different conclusions may represent differences in the experimental approaches used or may represent bona fide differences in the contribution of the second lineage to the hearts of birds compared to mammals [11]. Alternatively, the secondary/anterior heart fields described in the chick may represent a subset of a broader field that makes a more substantial contribution to the heart, as the mouse studies suggested - PMID:17276708 + anterior heart field - PMID:17276708 + anterior/second heart field Geisha:syn - NCBITaxon:8782 + NCBITaxon:8782 @@ -351688,7 +168918,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a developing face. - OBOL:automatic + OBOL:automatic @@ -351698,6 +168928,7 @@ The modern definition of neurosecretion has evolved to include the release of an todo - provide definition. Clearly distinguish between lobules, lobes and acinar parts of glands (see for example lobule of mammary gland) + FMA:45737 NCIT:C12990 UMLS:C0921005 @@ -351711,7 +168942,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -351724,7 +168955,7 @@ The modern definition of neurosecretion has evolved to include the release of an lobulus FMA:45737 - FMA:TA + FMA:TA @@ -351735,9 +168966,9 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of an organ, such as the liver, lung, breast, or brain. + FMA:45728 NCIT:C13393 - UMLS:C0796494 lobus uberon UBERON:0009912 @@ -351748,7 +168979,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -351761,7 +168992,7 @@ The modern definition of neurosecretion has evolved to include the release of an lobus FMA:45728 - FMA:TA + FMA:TA @@ -351788,7 +169019,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -351799,7 +169030,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -351841,7 +169072,7 @@ The modern definition of neurosecretion has evolved to include the release of an A multicellular organism that existence_starts_with a post-embryonic stage. - OBOL:automatic + OBOL:automatic @@ -351853,13 +169084,13 @@ The modern definition of neurosecretion has evolved to include the release of an post-hatching organism - https://orcid.org/0000-0002-6601-2165 + post-natal organism - https://orcid.org/0000-0002-6601-2165 + @@ -351921,9 +169152,9 @@ The modern definition of neurosecretion has evolved to include the release of an Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia. Includes: trigeminal, otic, lateral line and epibranchial placodes. While some sensory placodes (otic and olfactory) may have homologues in basal chordates (Wada et al., 1998), the so-called neurogenenic placodes (trigeminal, otic, lateral line and epibranchial placodes) appear to have emerged at a later time (Shimeld and Holland, 2000) + EFO:0003460 TAO:0001309 - Wikipedia:Neurogenic_placodes XAO:0004620 ZFA:0001309 neurogenic placodes @@ -351937,14 +169168,14 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia. - PMID:11523831 - http://orcid.org/0000-0002-6601-2165 + + @@ -351957,13 +169188,13 @@ The modern definition of neurosecretion has evolved to include the release of an neurogenic placodes ZFA:0001309 - + placodae neurogenicae - Wikipedia:Neurogenic_placodes + @@ -352024,7 +169255,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a pancreatic duct. - OBOL:automatic + OBOL:automatic @@ -352069,15 +169300,11 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical structure that has more than one cell as a part. - - - CARO:0010000 FBbt:00100313 multicellular structure uberon UBERON:0010000 - multicellular anatomical structure @@ -352102,58 +169329,44 @@ The modern definition of neurosecretion has evolved to include the release of an - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF]. - May be obsoleted. - FMA:256381 - NLXANAT:20090509 + + + + + A small cluster of cells of various types which form a discrete structure, largely delimited by a morphological boundary and whose components work together to make the whole structure capable of a specific function. + CARO:0010001 + FBbt:00007229 uberon - set of nuclei of neuraxis - UBERON:0010009 - - aggregate regional part of brain + UBERON:0010001 + + Examples include arthropod sensilla. + cell cluster organ - - - A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF]. - NLXANAT:20090509 + + + + CARO - - - set of nuclei of neuraxis - FMA:256381 + + + + CARO + + + + + + FBbt + + + + + A small cluster of cells of various types which form a discrete structure, largely delimited by a morphological boundary and whose components work together to make the whole structure capable of a specific function. + CARO:0010001 @@ -352194,7 +169407,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a pharyngeal arch 6. - OBOL:automatic + OBOL:automatic @@ -352202,6 +169415,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -352230,7 +169444,7 @@ The modern definition of neurosecretion has evolved to include the release of an An organ of the digestive tract that is capable of retaining and storing food. - https://orcid.org/0000-0002-6601-2165 + @@ -352267,7 +169481,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a pharyngeal arch 1. - OBOL:automatic + OBOL:automatic @@ -352313,7 +169527,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a 1st arch maxillary component. - OBOL:automatic + OBOL:automatic @@ -352329,6 +169543,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -352356,7 +169571,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -352367,7 +169582,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -352378,14 +169593,14 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells. + XAO:0004524 - https://orcid.org/0000-0002-6601-2165 @@ -352397,7 +169612,7 @@ The modern definition of neurosecretion has evolved to include the release of an entire branchial arch associated mesenchyme - https://orcid.org/0000-0002-6601-2165 + @@ -352452,13 +169667,13 @@ The modern definition of neurosecretion has evolved to include the release of an Gland of the epithelium lining the oral cavity. The most common are the salivary glands. - ISBN:0073040584 + ISBN:0073040584 Note that Kardong classifies lacrimal glands here. EHDAA2 includes pituitary primordium, as this develops from oral mucosa - EHDAA2 + EHDAA2 @@ -352470,9 +169685,10 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium consisting of cuboidal epithelial cells. TODO - coordinate with CL, add cuboidal cell in NCIT this is glandular + + NCIT:C32415 UMLS:C0682577 - Wikipedia:Cuboidal_epithelium uberon UBERON:0010077 cuboidal epithelium @@ -352481,7 +169697,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium consisting of cuboidal epithelial cells. - Wikipedia:Cuboidal_epithelium + @@ -352538,7 +169754,7 @@ The modern definition of neurosecretion has evolved to include the release of an An extrahepatic bile duct that has the potential to develop into a common hepatic duct. - OBOL:automatic + OBOL:automatic @@ -352557,6 +169773,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -352598,7 +169815,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -352609,7 +169826,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -352620,13 +169837,13 @@ The modern definition of neurosecretion has evolved to include the release of an - XAO + XAO Mesenchyme that has the potential to develop into a dermis. - OBOL:automatic + OBOL:automatic @@ -352685,7 +169902,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -352696,7 +169913,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:23586979 + @@ -352707,13 +169924,13 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:23586979 + A structure that will develop into a diaphragm. - http://orcid.org/0000-0002-6601-2165 + @@ -352755,7 +169972,7 @@ The modern definition of neurosecretion has evolved to include the release of an A developing anatomical structure that has the potential to develop into a metencephalon. - OBOL:automatic + OBOL:automatic @@ -352797,7 +170014,7 @@ The modern definition of neurosecretion has evolved to include the release of an A developing anatomical structure that has the potential to develop into a myelencephalon. - OBOL:automatic + OBOL:automatic @@ -352833,7 +170050,7 @@ The modern definition of neurosecretion has evolved to include the release of an A gray matter that has the potential to develop into a superior salivatory nucleus. - OBOL:automatic + OBOL:automatic @@ -352855,7 +170072,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers. - http://orcid.org/0000-0002-6601-2165 + @@ -352872,20 +170089,48 @@ The modern definition of neurosecretion has evolved to include the release of an - + - - - An epithelial sheet is a flat surface consisting of closely packed epithelial cells. + + + + + + + + + + + + + + + + + + + + + + + + + + + Any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli. + MA:0000720 + neuroendocrine system gland uberon - UBERON:0010136 - epithelial sheet + UBERON:0010133 + + neuroendocrine gland - + - An epithelial sheet is a flat surface consisting of closely packed epithelial cells. - GO:0002011 + Any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli. + ISBN:0-683-40008-8 + MP:0000631 @@ -352922,7 +170167,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mucous secretion that is produced by glands in the epidermis. - http://orcid.org/0000-0002-6601-2165 + @@ -352948,6 +170193,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -352961,8 +170207,8 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical cavity that surrounded_by a blood vessel. + FMA:312610 - SCTID:91747007 blood vessel lumen uberon UBERON:0010161 @@ -352972,7 +170218,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical cavity that surrounded_by a blood vessel. - OBOL:automatic + OBOL:automatic @@ -352991,6 +170237,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -353024,19 +170271,19 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA The distal end of the tail. - http://orcid.org/0000-0002-6601-2165 + EMAPA:37760 - MA:th + MA:th @@ -353087,13 +170334,13 @@ The modern definition of neurosecretion has evolved to include the release of an A trabecula that is part of a liver. GO:0060344 - OBOL:automatic + OBOL:automatic liver trabeculae - + @@ -353115,7 +170362,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -353129,8 +170376,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -353163,7 +170410,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -353174,7 +170421,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -353222,7 +170469,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia @@ -353255,7 +170502,7 @@ The modern definition of neurosecretion has evolved to include the release of an One of the laterally paired arteries that supply the gonads. - Wikipedia:Gonadal_artery + gonadal artery uberon UBERON:0010192 @@ -353270,14 +170517,14 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia One of the laterally paired arteries that supply the gonads. - ISBN:0073040584 - Wikipedia:Gonadal_artery + + ISBN:0073040584 @@ -353311,16 +170558,16 @@ The modern definition of neurosecretion has evolved to include the release of an A portal system that begins in capillaries in the wall of the digestive tract and and runs as the hepatic portal vein to the liver. - ISBN:0073040584 + ISBN:0073040584 Part of the circulatory system which includes the ventral abdominal vein, pelvic veins, and portal vein and collects blood from the pelvic region, liver, gall bladder and stomach.[AAO] - 2012-06-20 + 2012-06-20 AAO:0010225 - AAO - AAO:BJB + AAO + AAO:BJB @@ -353372,6 +170619,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -353394,13 +170642,13 @@ The modern definition of neurosecretion has evolved to include the release of an A vasculature that is part of a post-anal tail. - OBOL:automatic + OBOL:automatic isa blood vessel in XAO - XAO + XAO @@ -353453,7 +170701,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -353502,11 +170750,11 @@ The modern definition of neurosecretion has evolved to include the release of an The core globe-shaped component of the camera-type eye. See notes for camera-type eye + + FMA:12513 MIAA:0000283 - SCTID:244486005 VHOG:0001616 - Wikipedia:Globe_(human_eye) bulbus oculi eye globe eyeball @@ -353526,13 +170774,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The core globe-shaped component of the camera-type eye. - UBERON:cjm + UBERON:cjm @@ -353562,48 +170810,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged. - merocrine - BTO:0002324 - MA:0003041 - Wikipedia:Merocrine - uberon - UBERON:0010243 - - merocrine gland - - - - - An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged. - MGI:anna - MP:0013544 - Wikipedia:Merocrine - - - - @@ -353669,7 +170875,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -353680,13 +170886,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme. - OBOL:automatic + OBOL:automatic @@ -353740,7 +170946,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -353751,7 +170957,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -353762,13 +170968,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme. - OBOL:automatic + OBOL:automatic @@ -353837,7 +171043,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -353848,7 +171054,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -353859,7 +171065,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -353876,17 +171082,17 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme. - OBOL:automatic + OBOL:automatic In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000580 - VHOG + VHOG + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) - http://bgee.unil.ch/ @@ -353962,7 +171168,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -353973,7 +171179,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -353984,7 +171190,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -354001,7 +171207,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme. - OBOL:automatic + OBOL:automatic @@ -354048,13 +171254,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that develops_from a rhombencephalon neural crest. - OBOL:automatic + OBOL:automatic @@ -354123,7 +171329,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme. - OBOL:automatic + OBOL:automatic @@ -354149,6 +171355,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -354167,7 +171374,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any anatomical space that is part of a vertebral column. - OBOL:automatic + OBOL:automatic @@ -354211,7 +171418,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -354222,7 +171429,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -354233,7 +171440,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -354280,7 +171487,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -354291,7 +171498,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -354313,8 +171520,7 @@ The modern definition of neurosecretion has evolved to include the release of an - . - Wikipedia:Sclera#Histology + uberon UBERON:0010291 layer of sclera @@ -354328,13 +171534,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm - - - - - . - Wikipedia:Sclera#Histology + cjm @@ -354371,13 +171571,13 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia An endothelium that is part of a sclera. - OBOL:automatic + OBOL:automatic @@ -354406,9 +171606,10 @@ The modern definition of neurosecretion has evolved to include the release of an A stroma that is part of a sclera. subsantia propria + + FMA:58365 NCIT:C33652 - SCTID:368851004 UMLS:C1704397 scleral stroma stroma of sclera @@ -354422,13 +171623,13 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia A stroma that is part of a sclera. - OBOL:automatic + OBOL:automatic @@ -354459,7 +171660,7 @@ The modern definition of neurosecretion has evolved to include the release of an substantia propria sclerae FMA:58365 - FMA:TA + FMA:TA @@ -354479,6 +171680,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -354502,8 +171704,8 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme surrounding the developing optic cup which develops into the sclera. - PMID:16496288 - https://orcid.org/0000-0002-6601-2165 + + @@ -354540,7 +171742,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a extraembryonic structure. - OBOL:automatic + OBOL:automatic @@ -354550,8 +171752,8 @@ The modern definition of neurosecretion has evolved to include the release of an Stratified squamous epithelium is a stratified squamous epithelium, the cells of which synthesizes but does not accumulate keratin. Examples: epithelium of vagina, epithelium of wall of esophagus. + FMA:45569 - Wikipedia:Stratified_squamous_epithelium#Nonkeratinized epithelium stratificatum squamosum noncornificatum nonkeratinizing stratified squamous epithelium stratified squamous non-keratinized epithelium @@ -354564,14 +171766,14 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Stratified squamous epithelium is a stratified squamous epithelium, the cells of which synthesizes but does not accumulate keratin. Examples: epithelium of vagina, epithelium of wall of esophagus. + FMA:45569 - Wikipedia:Stratified_squamous_epithelium#Nonkeratinized @@ -354589,13 +171791,13 @@ The modern definition of neurosecretion has evolved to include the release of an stratified squamous non-keratinized epithelium - http://orcid.org/0000-0002-6601-2165 + stratified squamous nonkeratinizing epithelium - http://orcid.org/0000-0002-6601-2165 + @@ -354614,6 +171816,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -354645,7 +171848,7 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional @@ -354657,10 +171860,10 @@ The modern definition of neurosecretion has evolved to include the release of an Multi-tissue structure that consists of the structures that develop into the retina and lens.[TAO] - 2012-08-14 + 2012-08-14 TAO:0002201 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -354698,7 +171901,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical structure that develops from the neural crest. - https://orcid.org/0000-0002-6601-2165 + @@ -354718,6 +171921,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -354735,7 +171939,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical structure that has some part that develops from the neural crest. - https://orcid.org/0000-0002-6601-2165 + @@ -354744,6 +171948,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -354760,8 +171965,8 @@ The modern definition of neurosecretion has evolved to include the release of an - GO - ZFA + GO + ZFA @@ -354817,13 +172022,13 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:16496288 + A skeletal element that is part of a orbital region. - OBOL:automatic + OBOL:automatic @@ -354867,28 +172072,28 @@ The modern definition of neurosecretion has evolved to include the release of an Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. - GO_REF:0000034 - PSPUB:0000170 + + GO_REF:0000034 + PSPUB:0000170 VSAO:0000049 - http://dx.plos.org/10.1371/journal.pone.0051070 Bony structure that encases the central nervous system and the primary sense organs of sight, olfaction, hearing, and equilibrium.[AAO] - 2012-06-20 + 2012-06-20 AAO:0000109 - AAO - AAO:LAP + AAO + AAO:LAP Skeletal system which is part of the skull, including the splanchnocranium, chondrocranium, and dermatocranium.[TAO] - 2012-08-14 + 2012-08-14 TAO:0000737 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -354941,13 +172146,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2-abduced + EHDAA2-abduced Mesenchyme that is part of a limb/fin bud. - OBOL:automatic + OBOL:automatic @@ -354995,13 +172200,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2-abduced + EHDAA2-abduced Mesenchyme that is part of a extraembryonic membrane. - OBOL:automatic + OBOL:automatic @@ -355055,7 +172260,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355066,7 +172271,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355077,13 +172282,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that develops_from a neural crest and is part of a maxillary process mesenchyme. - OBOL:automatic + OBOL:automatic @@ -355137,7 +172342,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355148,7 +172353,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355159,13 +172364,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a maxillary process mesenchyme. - OBOL:automatic + OBOL:automatic @@ -355219,7 +172424,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355230,7 +172435,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355241,13 +172446,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme. - OBOL:automatic + OBOL:automatic @@ -355301,7 +172506,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355312,7 +172517,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355323,13 +172528,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme. - OBOL:automatic + OBOL:automatic @@ -355377,7 +172582,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355388,7 +172593,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355399,13 +172604,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme. - OBOL:automatic + OBOL:automatic @@ -355453,7 +172658,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355464,7 +172669,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355475,13 +172680,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme. - OBOL:automatic + OBOL:automatic @@ -355531,7 +172736,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355542,13 +172747,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EMAPA + EMAPA Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme. - OBOL:automatic + OBOL:automatic @@ -355608,7 +172813,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355619,7 +172824,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355630,13 +172835,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme. - OBOL:automatic + OBOL:automatic @@ -355694,7 +172899,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355705,7 +172910,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -355716,13 +172921,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme. - OBOL:automatic + OBOL:automatic @@ -355772,7 +172977,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme. - OBOL:automatic + OBOL:automatic @@ -355823,7 +173028,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme. - OBOL:automatic + OBOL:automatic @@ -355846,8 +173051,8 @@ The modern definition of neurosecretion has evolved to include the release of an Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues. An endoskeleton is an internal support structure of an animal, composed of mineralized tissue. Endoskeleton develops within the skin or in the deeper body tissues. The vertebrate is basically an endoskeleton made up of two types of tissues (bone and cartilage). During early embryonic development the endoskeleton is composed of notochord and cartilage. The notochord in most vertebrates is replaced by vertebral column and cartilage is replaced by bone in most adults. In three phyla and one subclass of animals, endoskeletons of various complexity are found: Chordata, Echinodermata, Porifera, and Coleoidea. An endoskeleton may function purely for support (as in the case of sponges), but often serves as an attachment site for muscle and a mechanism for transmitting muscular forces. A true endoskeleton is derived from mesodermal tissue. Such a skeleton is present in echinoderms and chordates. The poriferan 'skeleton' consists of microscopic calcareous or siliceous spicules or a spongin network. The Coleoidae do not have a true endoskeleton in the evolutionary sense; here, a mollusk exoskeleton evolved into several sorts of internal structure, the 'cuttlebone' of cuttlefish being the best-known version. Yet they do have cartilaginous tissue in their body, even if it is not mineralized, especially in the head, where it forms a primitive cranium. The endoskeleton gives shape,support and protection to the body and provides a mean of locomotion.[Wikipedia:Endoskeleton]t + VSAO:0000037 - Wikipedia:Endoskeleton XAO:0004026 replacement skeleton uberon @@ -355858,28 +173063,28 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues. - GO_REF:0000034 - PSPUB:0000170 + + GO_REF:0000034 + PSPUB:0000170 VSAO:0000037 - http://dx.plos.org/10.1371/journal.pone.0051070 An endoskeleton is an internal support structure of an animal, composed of mineralized tissue. Endoskeleton develops within the skin or in the deeper body tissues. The vertebrate is basically an endoskeleton made up of two types of tissues (bone and cartilage). During early embryonic development the endoskeleton is composed of notochord and cartilage. The notochord in most vertebrates is replaced by vertebral column and cartilage is replaced by bone in most adults. In three phyla and one subclass of animals, endoskeletons of various complexity are found: Chordata, Echinodermata, Porifera, and Coleoidea. An endoskeleton may function purely for support (as in the case of sponges), but often serves as an attachment site for muscle and a mechanism for transmitting muscular forces. A true endoskeleton is derived from mesodermal tissue. Such a skeleton is present in echinoderms and chordates. The poriferan 'skeleton' consists of microscopic calcareous or siliceous spicules or a spongin network. The Coleoidae do not have a true endoskeleton in the evolutionary sense; here, a mollusk exoskeleton evolved into several sorts of internal structure, the 'cuttlebone' of cuttlefish being the best-known version. Yet they do have cartilaginous tissue in their body, even if it is not mineralized, especially in the head, where it forms a primitive cranium. The endoskeleton gives shape,support and protection to the body and provides a mean of locomotion.[Wikipedia:Endoskeleton]t - Wikipedia:Endoskeleton + replacement skeleton - VSAO:curator + VSAO:curator @@ -355902,16 +173107,16 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification. - GO_REF:0000034 - PSPUB:0000170 + + GO_REF:0000034 + PSPUB:0000170 VSAO:0000139 - http://dx.plos.org/10.1371/journal.pone.0051070 @@ -355948,41 +173153,41 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements. - GO_REF:0000034 - PSPUB:0000170 + + GO_REF:0000034 + PSPUB:0000170 VSAO:0000035 - http://dx.plos.org/10.1371/journal.pone.0051070 exoskeleton - VSAO:curator + VSAO:curator dermal skeletal system - VSAO:curator + VSAO:curator dermoskeleton - VSAO:curator + VSAO:curator desmoskeleton - VSAO:curator + VSAO:curator @@ -356011,8 +173216,8 @@ The modern definition of neurosecretion has evolved to include the release of an - - + + The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa. @@ -356034,7 +173239,7 @@ The modern definition of neurosecretion has evolved to include the release of an lobulus pulmonis FMA:75739 - FMA:TA + FMA:TA @@ -356129,7 +173334,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -356186,7 +173391,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -356248,7 +173453,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -356259,13 +173464,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that develops_from a somatopleure. - OBOL:automatic + OBOL:automatic @@ -356319,7 +173524,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -356330,13 +173535,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 Mesenchyme that develops_from a splanchnopleure. - OBOL:automatic + OBOL:automatic @@ -356355,12 +173560,12 @@ The modern definition of neurosecretion has evolved to include the release of an - + - + @@ -356371,7 +173576,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -356384,10 +173589,11 @@ The modern definition of neurosecretion has evolved to include the release of an One of the branches of the splenic artery[MP]. When the splenic artery passes into the trabecula of the spleen and branches, they become known as the trabecular arteries. When these arteries then reach the white pulp, and become covered with Periarteriolar lymphoid sheaths, the name changes again to central arteries (or central arterioles). Branches of the central arteries are given to the red pulp, and these are called penicillar arteries).[Wikipedia] + + MA:0000759 NCIT:C49775 UMLS:C1710159 - Wikipedia:Trabecular_arteries uberon trabecular artery UBERON:0010399 @@ -356400,25 +173606,25 @@ The modern definition of neurosecretion has evolved to include the release of an - + - MP + MP One of the branches of the splenic artery[MP]. + MP:0002354 - Wikipedia:Trabecular_arteries When the splenic artery passes into the trabecula of the spleen and branches, they become known as the trabecular arteries. When these arteries then reach the white pulp, and become covered with Periarteriolar lymphoid sheaths, the name changes again to central arteries (or central arterioles). Branches of the central arteries are given to the red pulp, and these are called penicillar arteries).[Wikipedia] Wikipedia - Wikipedia:Trabecular_arteries + @@ -356471,10 +173677,11 @@ The modern definition of neurosecretion has evolved to include the release of an One of the veins that feed the splenic vein. The trabecular veins are the largest veins inside the spleen. It drains the blood collected in the sinuses of the pulp.[Wikipedia] + + MA:0000760 NCIT:C49779 UMLS:C1710160 - Wikipedia:Trabecular_veins uberon trabecular vein UBERON:0010400 @@ -356486,15 +173693,15 @@ The modern definition of neurosecretion has evolved to include the release of an One of the veins that feed the splenic vein. + MP:0002228 - Wikipedia:Trabecular_veins The trabecular veins are the largest veins inside the spleen. It drains the blood collected in the sinuses of the pulp.[Wikipedia] Wikipedia - Wikipedia:Trabecular_veins + @@ -356506,7 +173713,7 @@ The modern definition of neurosecretion has evolved to include the release of an trabecular vein - Wikipedia:Trabecular_veins + @@ -356566,9 +173773,9 @@ The modern definition of neurosecretion has evolved to include the release of an The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens. + + FMA:76551 - SCTID:280860001 - Wikipedia:Ciliary_processes ciliary processes ciliary processes set processus ciliares @@ -356578,21 +173785,13 @@ The modern definition of neurosecretion has evolved to include the release of an processus ciliares UBERON:0010427 ciliary processes - http://upload.wikimedia.org/wikipedia/commons/b/b2/Gray875.png - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_L.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_R.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Eye_L.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Eye_R.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-eye-l.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-eye-r.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-eye-l.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-eye-r.glb + http://upload.wikimedia.org/wikipedia/commons/b/b2/Gray875.png The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens. - Wikipedia:Ciliary_processes + @@ -356610,7 +173809,7 @@ The modern definition of neurosecretion has evolved to include the release of an processus ciliares - FMA:TA + FMA:TA @@ -356623,13 +173822,13 @@ The modern definition of neurosecretion has evolved to include the release of an ciliary process - Wikipedia:Ciliary_processes + processus ciliares - Wikipedia:Ciliary_processes + @@ -356648,11 +173847,12 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow. In an adult mammal, most red blood cells are formed in flat bones Flat bones are those bones which are found where the principal requirement is either extensive protection or the provision of broad surfaces for muscular attachment + + + FMA:7476 NCIT:C32616 - SCTID:332907008 UMLS:C0222649 - Wikipedia:Flat_bone galen:FlatBone uberon os planum @@ -356664,13 +173864,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow. - Wikipedia:Flat_bone + @@ -356682,7 +173882,7 @@ The modern definition of neurosecretion has evolved to include the release of an os planum - Wikipedia:Flat_bone + @@ -356695,12 +173895,14 @@ The modern definition of neurosecretion has evolved to include the release of an A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels. Pseudostratified epithelia function in secretion or absorption. If a specimen looks stratified but has cilia, then it is a pseudostratified ciliated epithelium, since stratified epithelia do not have cilia. glandular in NCIT; we consider the two NCIT terms synonymous + + + FMA:45572 NCIT:C33419 NCIT:C49316 UMLS:C0836138 UMLS:C1514590 - Wikipedia:Pseudostratified_columnar_epithelium uberon UBERON:0010498 pseudostratified columnar epithelium @@ -356709,14 +173911,14 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels. - Wikipedia:Pseudostratified_columnar_epithelium - http://medical-dictionary.thefreedictionary.com/pseudostratified+epithelium + + @@ -356762,6 +173964,7 @@ The modern definition of neurosecretion has evolved to include the release of an Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile. + FMA:13146 NCIT:C13181 UMLS:C0506992 @@ -356823,7 +174026,7 @@ The modern definition of neurosecretion has evolved to include the release of an An organ that is capable of detecting electrical stimulus. - http://orcid.org/0000-0002-6601-2165 + @@ -356850,7 +174053,7 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO @@ -356861,16 +174064,16 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm Skeletal element that forms as a replacement or substitution of another element or tissue. - GO_REF:0000034 - PSPUB:0000170 + + GO_REF:0000034 + PSPUB:0000170 VSAO:0000135 - http://dx.plos.org/10.1371/journal.pone.0051070 @@ -356903,22 +174106,22 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses. + MESH:A07.231.432 ZFA:0005251 - http://orcid.org/0000-0002-6601-2165 microcirculatory vessels TAO:0005251 - + @@ -356955,7 +174158,7 @@ The modern definition of neurosecretion has evolved to include the release of an An organ cavity that surrounded_by a bone. - OBOL:automatic + OBOL:automatic @@ -356986,7 +174189,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -357044,50 +174247,50 @@ The modern definition of neurosecretion has evolved to include the release of an An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). - https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton - https://orcid.org/0000-0002-6601-2165 + + Anatomical group that consists of the soft and skeletal tissues of the appendicular region of the body and the appendage proper.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000214 - VSAO + VSAO GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 It is still called a complex when one of the two parts is missing (?) There are fossil fishes with only an outgrowth (no record of a girdle), including thelodonts (which have a suprabranchial fin) as well as some anaspids which have a distinctive 'paired fin' (with differing published assertions on whether it's homologous to a pec fin or pelvic fin or both or neither). There are many fishes and other vertebrates with only a girdle and no outgrowth.[VSAO] - 2012-09-06 + 2012-09-06 VSAO:0000214 - VSAO - Curator + VSAO + Curator note that the FMA uses the term 'limb' to refer to the entire appendage complex (free limb plus girdle region) - FMA + FMA EMAPA:37858 - MA:th + MA:th appendage complex - https://orcid.org/0000-0002-6601-2165 + appendage-girdle complex - https://orcid.org/0000-0002-6601-2165 + @@ -357099,7 +174302,7 @@ The modern definition of neurosecretion has evolved to include the release of an girdle plus limb or fin - https://orcid.org/0000-0002-6601-2165 + @@ -357141,9 +174344,9 @@ The modern definition of neurosecretion has evolved to include the release of an Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle. Appendage girdle complex that when present, encompasses the pectoral appendage and half of the pectoral girdle.[VSAO] note that the FMA uses the terms 'upper limb' and 'lower limb' to refer to the entire appendage complex (free limb plus girdle region) + EMAPA:37860 FMA:7183 - SCTID:110716002 VSAO:0000213 pectoral appendage/girdle complex pectoral girdle plus anterior limb or fin @@ -357166,22 +174369,22 @@ The modern definition of neurosecretion has evolved to include the release of an Appendage girdle complex that when present, encompasses the pectoral appendage and half of the pectoral girdle.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000213 - VSAO + VSAO VSAO:MAH note that the FMA uses the terms 'upper limb' and 'lower limb' to refer to the entire appendage complex (free limb plus girdle region) - FMA + FMA EMAPA:37860 - MA:th + MA:th @@ -357193,13 +174396,13 @@ The modern definition of neurosecretion has evolved to include the release of an pectoral girdle plus anterior limb or fin - https://orcid.org/0000-0002-6601-2165 + pectoral girdle plus pectoral limb or fin - https://orcid.org/0000-0002-6601-2165 + @@ -357212,14 +174415,14 @@ The modern definition of neurosecretion has evolved to include the release of an upper limb and pectoral girdle - https://orcid.org/0000-0002-6601-2165 + upper limb and shoulder - https://orcid.org/0000-0002-6601-2165 + @@ -357238,6 +174441,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -357255,9 +174459,9 @@ The modern definition of neurosecretion has evolved to include the release of an Appendage girdle complex that when present, encompasses the pelvic appendage and the pelvic girdle.[VSAO] note that the FMA uses the terms 'upper limb' and 'lower limb' to refer to the entire appendage complex (free limb plus girdle region). Note the MA class 'hindlimb' may also belong here + EMAPA:37863 FMA:7184 - SCTID:416631005 VSAO:0000215 pelvic appendage/girdle complex pelvic girdle plus pelvic limb or fin @@ -357280,22 +174484,22 @@ The modern definition of neurosecretion has evolved to include the release of an Appendage girdle complex that when present, encompasses the pelvic appendage and the pelvic girdle.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000215 - VSAO + VSAO VSAO:MAH note that the FMA uses the terms 'upper limb' and 'lower limb' to refer to the entire appendage complex (free limb plus girdle region). Note the MA class 'hindlimb' may also belong here - FMA + FMA EMAPA:37863 - MA:th + MA:th @@ -357307,13 +174511,13 @@ The modern definition of neurosecretion has evolved to include the release of an pelvic girdle plus pelvic limb or fin - https://orcid.org/0000-0002-6601-2165 + pelvic girdle plus posterior limb or fin - https://orcid.org/0000-0002-6601-2165 + @@ -357326,14 +174530,14 @@ The modern definition of neurosecretion has evolved to include the release of an lower limb and pelvic girdle - https://orcid.org/0000-0002-6601-2165 + lower limb and pelvis - https://orcid.org/0000-0002-6601-2165 + @@ -357398,32 +174602,32 @@ The modern definition of neurosecretion has evolved to include the release of an The subdivision of the skeleton of either the pectoral or pelvic girdle. - https://orcid.org/0000-0002-6601-2165 + Skeletal subdivision that is part of the appendage girdle region.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000302 - VSAO + VSAO GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: part_of subdivision of skeleton (UBERON:0010912)[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000302 - VSAO + VSAO relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: proximally_connected_to subdivision of skeleton (UBERON:0010912)[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000302 - VSAO + VSAO @@ -357486,15 +174690,15 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle). + UBERONREF:0000003 - https://orcid.org/0000-0002-6601-2165 bone of extended limb/fin region + UBERONREF:0000003 - https://orcid.org/0000-0002-6601-2165 @@ -357551,35 +174755,35 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin. - UBERONREF:0000003 - https://orcid.org/0000-0002-6601-2165 + + UBERONREF:0000003 note that the MA class includes girdle parts so it belongs here; - MA + MA wing bone - UBERONREF:0000003 + UBERONREF:0000003 bone of forelimb or pectoral fin or pectoral girdle - UBERONREF:0000003 - https://orcid.org/0000-0002-6601-2165 + + UBERONREF:0000003 forelimb bone MA:0000612 - UBERONREF:0000003 + UBERONREF:0000003 @@ -357626,27 +174830,27 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA A bone that is part of a pelvic complex. Examples: pubis, ischium, fot phalanx, any tarsal bone, any bone of the pelvic fin or girdle. - UBERONREF:0000003 - https://orcid.org/0000-0002-6601-2165 + + UBERONREF:0000003 the MA class called 'hindlimb bone' belongs here, as it includes bones in the pelvic girdle - MA + MA hindlimb bone MA:0000660 - UBERONREF:0000003 + UBERONREF:0000003 @@ -357704,22 +174908,22 @@ The modern definition of neurosecretion has evolved to include the release of an - prolog + prolog Muscles of the pelvic girdle, hindlimb or pelvic fin. - https://orcid.org/0000-0002-6601-2165 + Muscles of the pelvic girdle, thigh, leg (crus), and foot (pes).[AAO] - 2012-06-20 + 2012-06-20 AAO:0000218 - AAO - AAO:EJS + AAO + AAO:EJS @@ -357731,13 +174935,13 @@ The modern definition of neurosecretion has evolved to include the release of an pelvic girdle or hind limb muscle - https://orcid.org/0000-0002-6601-2165 + pelvic girdle or posterior limb muscle - https://orcid.org/0000-0002-6601-2165 + @@ -357808,22 +175012,22 @@ The modern definition of neurosecretion has evolved to include the release of an - prolog + prolog A muscle of a pectoral girdle, pectoral fin or anterior limb. - https://orcid.org/0000-0002-6601-2165 + Muscles of the pectoral girdle, arm, forearm, and hand (brachium, antebrachium, manus respectively).[AAO] - 2012-06-20 + 2012-06-20 AAO:0010687 - AAO - AAO:EJS + AAO + AAO:EJS @@ -357835,7 +175039,7 @@ The modern definition of neurosecretion has evolved to include the release of an muscle of pectoral girdle and wing - NCBITaxon:8782 + NCBITaxon:8782 @@ -357873,8 +175077,8 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO] + FMA:23879 - SCTID:129140006 VSAO:0000042 skeletal subdivision uberon @@ -357887,7 +175091,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -357909,23 +175113,23 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. + UBERONREF:0000003 - https://orcid.org/0000-0002-6601-2165 Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000042 incorrect - VSAO + VSAO VSAO:curator @@ -357946,7 +175150,14 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + @@ -357973,8 +175184,19 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO - https://github.com/obophenotype/uberon/issues/82 + + VSAO + + + + + + + + + + + VSAO @@ -357985,50 +175207,50 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm Skeletal element that forms around the notochord and is part of the vertebral column. - GO_REF:0000034 + + + GO_REF:0000034 VSAO:0000184 - http://dx.plos.org/10.1371/journal.pone.0051070 - https://github.com/obophenotype/uberon/issues/294 In contrast to lampreys and jawed vertebrates, hagfishes were thought to lack vertebrae. Now, long overlooked vertebral rudiments have been analysed in hagfish, suggesting that vertebrae existed in the last common ancestor of all vertebrates.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001143 - VHOG + VHOG + DOI:10.1016/j.cub.2011.07.014 Janvier P, Comparative anatomy: all vertebrates do have vertebrae. Current Biology (2011) - http://bgee.unil.ch/ vertebra skeletal element - https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern + vertebra element - https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern + vertebra endochondral element - https://github.com/obophenotype/uberon/issues/82 + vertebral endochondral element - https://github.com/obophenotype/uberon/issues/82 + @@ -358061,6 +175283,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any muscle organ that is part of either the head or the neck. + NCIT:C32716 UMLS:C0448281 muscle of head or neck @@ -358078,13 +175301,13 @@ The modern definition of neurosecretion has evolved to include the release of an - prolog + prolog Any muscle organ that is part of either the head or the neck. - http://orcid.org/0000-0002-6601-2165 + @@ -358110,6 +175333,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -358123,7 +175347,6 @@ The modern definition of neurosecretion has evolved to include the release of an A cartilage element that is part of a splanchnocranium. - BTO:0006051 EFO:0003689 TAO:0001460 ZFA:0001460 @@ -358138,7 +175361,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -358149,26 +175372,20 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA A cartilage element that is part of a splanchnocranium. - OBOL:automatic - - - - - BTO:0006051 - https://orcid.org/0000-0003-4423-4370 + OBOL:automatic pharyngeal arch cartilages ZFA:0001460 - + @@ -358227,7 +175444,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -358238,24 +175455,24 @@ The modern definition of neurosecretion has evolved to include the release of an - VHOG + VHOG The dorsal portion of the first pharyngeal arch, comprising the upper jaw[ZFIN,VHOG]. + VHOG:0000511 - https://github.com/obophenotype/uberon/issues/153 Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0000511 - VHOG + VHOG + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) - http://bgee.unil.ch/ @@ -358339,7 +175556,7 @@ The modern definition of neurosecretion has evolved to include the release of an A skeleton of pelvic girdle that is part of a right pelvic girdle region. - OBOL:automatic + OBOL:automatic @@ -358375,7 +175592,7 @@ The modern definition of neurosecretion has evolved to include the release of an A skeleton of pelvic girdle that is part of a left pelvic girdle region. - OBOL:automatic + OBOL:automatic @@ -358419,7 +175636,7 @@ The modern definition of neurosecretion has evolved to include the release of an A pelvic girdle region that is in the right side of a multicellular organism. - OBOL:automatic + OBOL:automatic @@ -358470,7 +175687,7 @@ The modern definition of neurosecretion has evolved to include the release of an A pelvic girdle region that is in the left side of a multicellular organism. - OBOL:automatic + OBOL:automatic @@ -358530,10 +175747,10 @@ The modern definition of neurosecretion has evolved to include the release of an The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. - GO_REF:0000034 + + + GO_REF:0000034 VSAO:0000184 - http://dx.plos.org/10.1371/journal.pone.0051070 - http://orcid.org/0000-0002-6601-2165 @@ -358546,7 +175763,7 @@ The modern definition of neurosecretion has evolved to include the release of an This class is a superclass of individual vertebral cartilage condensations. Note that EHDAA2 represents these as condensation groups - EHDAA2 + EHDAA2 @@ -358607,16 +175824,16 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2-abduced + EHDAA2-abduced The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. - GO_REF:0000034 + + + GO_REF:0000034 VSAO:0000184 - http://dx.plos.org/10.1371/journal.pone.0051070 - http://orcid.org/0000-0002-6601-2165 @@ -358656,6 +175873,7 @@ The modern definition of neurosecretion has evolved to include the release of an A synovial joint that is part of a pelvic girdle region. + FMA:35173 NCIT:C32890 UMLS:C0827002 @@ -358669,7 +175887,7 @@ The modern definition of neurosecretion has evolved to include the release of an A synovial joint that is part of a pelvic girdle region. - OBOL:automatic + OBOL:automatic @@ -358716,8 +175934,8 @@ The modern definition of neurosecretion has evolved to include the release of an A synovial joint that is part of a pectoral girdle region. in FMA, these are part of the bony pectoral girdle + FMA:35243 - SCTID:303080001 joint of shoulder girdle pectoral girdle joint uberon @@ -358728,13 +175946,13 @@ The modern definition of neurosecretion has evolved to include the release of an A synovial joint that is part of a pectoral girdle region. - OBOL:automatic + OBOL:automatic in FMA, these are part of the bony pectoral girdle - FMA + FMA @@ -358760,7 +175978,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -358781,12 +175999,19 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + @@ -358804,13 +176029,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Subdivision of the skeletal system which consists of the axial skeleton plus associated joints. - https://orcid.org/0000-0002-6601-2165 + @@ -358819,6 +176044,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -358839,7 +176065,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -358850,20 +176076,20 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints. - https://github.com/obophenotype/uberon/issues/44 - https://orcid.org/0000-0002-6601-2165 + + axial skeletal system - https://github.com/obophenotype/uberon/wiki/The-axial-skeleton + @@ -358896,9 +176122,9 @@ The modern definition of neurosecretion has evolved to include the release of an Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue. + BTO:0003751 EMAPA:37970 - Wikipedia:Submucosal_glands uberon UBERON:0011148 submucosal gland @@ -358918,14 +176144,14 @@ The modern definition of neurosecretion has evolved to include the release of an Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue. + BTO:0003751 - Wikipedia:Submucosal_glands EMAPA:37970 - MA:th + MA:th @@ -358948,12 +176174,12 @@ The modern definition of neurosecretion has evolved to include the release of an Subdivision of skull that consists of the facial bones. + EHDAA2:0002206 EHDAA:8361 EMAPA:18022 FMA:53673 MA:0000318 - Wikipedia:Facial_skeleton facial skeleton uberon facial bone @@ -358963,13 +176189,13 @@ The modern definition of neurosecretion has evolved to include the release of an UBERON:0011156 facial skeleton - http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg + http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg - FMA + FMA @@ -358980,7 +176206,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -358991,16 +176217,16 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:11523816 + Subdivision of skull that consists of the facial bones. + + + MP:0005274 - Wikipedia:Facial_skeleton - http://www.bartleby.com/107/37.html - https://orcid.org/0000-0002-6601-2165 @@ -359018,14 +176244,14 @@ The modern definition of neurosecretion has evolved to include the release of an ossa facialia - Wikipedia:Facial_skeleton + ossa faciei - Wikipedia:Facial_skeleton + @@ -359061,13 +176287,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The skull can be divided into two: the neurocranium and the facial skeleton. - http://orcid.org/0000-0002-6601-2165 + @@ -359103,7 +176329,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -359122,7 +176348,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -359131,9 +176356,9 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a neurocranium [Automatically generated definition]. + EMAPA:35238 MA:0001478 - SCTID:120229002 chondrocranium bone uberon UBERON:0011164 @@ -359143,7 +176368,7 @@ The modern definition of neurosecretion has evolved to include the release of an A bone that is part of a neurocranium [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -359204,14 +176429,14 @@ The modern definition of neurosecretion has evolved to include the release of an Synovial joint that articulates bones of upper and lower jaw. - http://evolution.berkeley.edu/evolibrary/article/evograms_05 - https://orcid.org/0000-0002-6601-2165 + + Some synapsids retained two pairs of jaw joints - quadrate-articular and tempero-mandibular, but this unusual paired condition did not last long - http://evolution.berkeley.edu + @@ -359239,6 +176464,7 @@ The modern definition of neurosecretion has evolved to include the release of an A sphincter muscle that is part of the gastrointestinal system. + NCIT:C32669 UMLS:C1517464 uberon @@ -359249,7 +176475,7 @@ The modern definition of neurosecretion has evolved to include the release of an A sphincter muscle that is part of the gastrointestinal system. - OBOL:automatic + OBOL:automatic @@ -359295,6 +176521,7 @@ The modern definition of neurosecretion has evolved to include the release of an A lamina propria that is part of a large intestine. + FMA:15654 NCIT:C49298 UMLS:C1708644 @@ -359315,7 +176542,7 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships + @@ -359326,13 +176553,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A lamina propria that is part of a large intestine. - OBOL:automatic + OBOL:automatic @@ -359383,6 +176610,7 @@ The modern definition of neurosecretion has evolved to include the release of an A muscle layer that is part of a large intestine. + FMA:14971 NCIT:C32927 UMLS:C0734205 @@ -359403,13 +176631,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A muscle layer that is part of a large intestine. - OBOL:automatic + OBOL:automatic @@ -359439,7 +176667,7 @@ The modern definition of neurosecretion has evolved to include the release of an tunica muscularis intestini crassi - FMA:TA + FMA:TA @@ -359473,9 +176701,10 @@ The modern definition of neurosecretion has evolved to include the release of an A muscle layer that is part of a small intestine. + + FMA:14932 NCIT:C33569 - SCTID:362145004 UMLS:C0227269 muscular coat of small intestine muscular layer of small intestine @@ -359496,13 +176725,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A muscle layer that is part of a small intestine. - OBOL:automatic + OBOL:automatic @@ -359544,7 +176773,7 @@ The modern definition of neurosecretion has evolved to include the release of an tunica muscularis intestini tenuis - FMA:TA + FMA:TA @@ -359564,7 +176793,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -359585,7 +176814,7 @@ The modern definition of neurosecretion has evolved to include the release of an A multi cell part structure that is part of a central nervous system. - OBOL:automatic + OBOL:automatic @@ -359613,15 +176842,11 @@ The modern definition of neurosecretion has evolved to include the release of an A subdivision of an anatomical system. - - - + FBbt:00007330 FMA:67509 - SCTID:91690000 uberon UBERON:0011216 - organ system subdivision @@ -359631,11 +176856,17 @@ The modern definition of neurosecretion has evolved to include the release of an FBbt + + + + + FBbt + A subdivision of an anatomical system. - http://orcid.org/0000-0002-6601-2165 + @@ -359683,16 +176914,16 @@ The modern definition of neurosecretion has evolved to include the release of an - EMAPA + EMAPA Muscles within the eye (bulbus oculi).[AAO] - 2012-06-20 + 2012-06-20 AAO:0010038 - AAO - AAO:EJS + AAO + AAO:EJS @@ -359732,9 +176963,9 @@ The modern definition of neurosecretion has evolved to include the release of an Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa. synovium + BTO:0001823 FMA:40878 - Wikipedia:Synovial_sheath uberon UBERON:0011233 Alternate def: A synovial sheath is a layer of a tendon sheath containing tendons in the hand and foot. They lie internal to the fibrous tendon sheaths. An example is the common synovial sheath for the flexor tendons. [Wikipedia:Synovial_sheath] @@ -359744,8 +176975,8 @@ The modern definition of neurosecretion has evolved to include the release of an Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa. + FMA:45087 - Wikipedia:Synovial_sheath @@ -359774,7 +177005,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -359805,6 +177035,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -359829,8 +177060,8 @@ The modern definition of neurosecretion has evolved to include the release of an The most anterior region of the braincase. Provides structural support for peripheral olfactory organ. + UBERONREF:0000007 - http://palaeos.com/vertebrates/bones/braincase/ethmoid.html @@ -359865,16 +177096,16 @@ The modern definition of neurosecretion has evolved to include the release of an Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints. - https://orcid.org/0000-0002-6601-2165 + Skeletal system which consists of the appendicular skeleton plus associated joints.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000306 - VSAO - https://orcid.org/0000-0002-6601-2165 + VSAO + @@ -359891,10 +177122,10 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the trunk that is in the dorsum[cjm]. In humans, the subdivision of trunk which is demarcated from the trunk proper by the external surface of the posterolateral part of the rib cage, the anterior surface of the thoracic vertebral column and the posterior axillary lines, the external surface of the posterior abdominal wall; together with the trunk proper, it constitutes the trunk[FMA] + EMAPA:35162 FMA:25056 MA:0000020 - Wikipedia:Human_back back of trunk dorsal part of trunk dorsum of trunk @@ -359907,7 +177138,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -359918,14 +177149,14 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The part of the trunk that is in the dorsum[cjm]. + UBERONREF:0000006 - Wikipedia:Human_back @@ -359977,7 +177208,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -359988,7 +177219,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -359999,7 +177230,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -360047,16 +177278,16 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vasculature that is part of a head. - OBOL:automatic + OBOL:automatic Blood vessel part of cranial vasculature.[TAO] - 2012-08-14 + 2012-08-14 TAO:0005297 - TAO - ZFIN:curator + TAO + ZFIN:curator @@ -360069,7 +177300,7 @@ The modern definition of neurosecretion has evolved to include the release of an cranial blood vessels TAO:0005297 - + @@ -360084,8 +177315,8 @@ The modern definition of neurosecretion has evolved to include the release of an + FMA:54364 - SCTID:432899004 cavity of digestive tract cavity of gastrointestinal tract gastrointestinal tract lumen @@ -360124,6 +177355,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -360143,9 +177375,9 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical cavity that is part of a esophagus. + EMAPA:18380 FMA:9398 - SCTID:322648002 cavity of eosophagus cavity of esophagus eosophageal cavity @@ -360168,13 +177400,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA An anatomical cavity that is part of a esophagus. - OBOL:automatic + OBOL:automatic @@ -360269,15 +177501,15 @@ The modern definition of neurosecretion has evolved to include the release of an The collection of all skeletal elements in an individual limb or fin. - https://orcid.org/0000-0002-6601-2165 + Skeletal subdivision that is part of the paired limb/fin.[VSAO] - 2012-08-14 + 2012-08-14 VSAO:0000301 - VSAO + VSAO GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 @@ -360305,16 +177537,16 @@ The modern definition of neurosecretion has evolved to include the release of an - VSAO + VSAO Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995). - GO_REF:0000034 - PSPUB:0000170 + + GO_REF:0000034 + PSPUB:0000170 VSAO:0000006 - http://dx.plos.org/10.1371/journal.pone.0051070 @@ -360324,6 +177556,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -360352,7 +177585,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -360363,7 +177596,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -360447,7 +177680,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EMAPA + EMAPA FMA-abduced ZFA-abduced @@ -360455,7 +177688,7 @@ The modern definition of neurosecretion has evolved to include the release of an A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions. - http://orcid.org/0000-0002-6601-2165 + @@ -360487,7 +177720,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -360498,7 +177731,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -360509,7 +177742,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia:Mandibular_prominence + @@ -360559,7 +177792,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any bone that is part of the upper jaw skeleton. This includes (when present): the maxilla, the quadrate (in some species). - https://orcid.org/0000-0002-6601-2165 + @@ -360613,7 +177846,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -360624,13 +177857,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 An epithelium that develops_from a ectoderm and is part of a oral epithelium. - OBOL:automatic + OBOL:automatic @@ -360669,7 +177902,7 @@ The modern definition of neurosecretion has evolved to include the release of an mandibular muscles TAO:0000236 - + @@ -360698,7 +177931,7 @@ The modern definition of neurosecretion has evolved to include the release of an A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column. - https://orcid.org/0000-0002-6601-2165 + @@ -360739,7 +177972,7 @@ The modern definition of neurosecretion has evolved to include the release of an - true + true @@ -360751,7 +177984,7 @@ The modern definition of neurosecretion has evolved to include the release of an presacral vertebra - http://orcid.org/0000-0002-6601-2165 + @@ -360792,7 +178025,7 @@ The modern definition of neurosecretion has evolved to include the release of an A cardiovascular system that is part of a conceptus. - OBOL:automatic + OBOL:automatic @@ -360812,6 +178045,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -360834,7 +178068,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical space that is part of a bone of lower jaw. - OBOL:automatic + OBOL:automatic @@ -360854,6 +178088,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -360876,7 +178111,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical space that is part of a bone of upper jaw. - OBOL:automatic + OBOL:automatic @@ -360914,7 +178149,7 @@ The modern definition of neurosecretion has evolved to include the release of an A neural nucleus that is part of the spinal cord. - http://orcid.org/0000-0002-6601-2165 + @@ -360958,7 +178193,7 @@ The modern definition of neurosecretion has evolved to include the release of an A nerve that is part of a head. - OBOL:automatic + OBOL:automatic @@ -360976,14 +178211,14 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm Ectodermal placode that does not develop into a component of the nervous system. - PMID:11523831 - http://orcid.org/0000-0002-6601-2165 + + @@ -361048,19 +178283,19 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart. - http://orcid.org/0000-0002-6601-2165 + AV region - PMID:21234997 + AV segment - PMID:21234997 + @@ -361079,7 +178314,7 @@ The modern definition of neurosecretion has evolved to include the release of an atrioventricular segment - PMID:21234997 + @@ -361098,7 +178333,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -361143,10 +178378,11 @@ The modern definition of neurosecretion has evolved to include the release of an Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium. Tissue characterized by a thick, random arrangement of collagen and elastin fibers with very few cells. The majority of the cells are fibroblasts, but mast cells and macrophages may also be seen. It is found in the dermis, periosteum, perichondrium, capsules of organs and sheaths of nerves and muscles[NCIT] + + FMA:20109 NCIT:C32882 UMLS:C0738366 - Wikipedia:Dense_irregular_connective_tissue irregular dense connective tissue typus irregularis (textus connectivus collagenosus compactus) uberon @@ -361157,14 +178393,14 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium. + FMA:20109 - Wikipedia:Dense_irregular_connective_tissue @@ -361203,7 +178439,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -361215,10 +178450,11 @@ The modern definition of neurosecretion has evolved to include the release of an Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets. our OWL definition states that this is differentiated from other connective tissue types by virtue of the fact that the collage fiber component predominates, as opposed to cells and fluid. Connective tissue in which the fibrous component predominates. The cells, ground substance, and tissue fluid represent a minor component[NCIT] + + AAO:0000121 NCIT:C32450 UMLS:C1511770 - Wikipedia:Dense_connective_tissue uberon UBERON:0011823 dense connective tissue @@ -361227,7 +178463,7 @@ The modern definition of neurosecretion has evolved to include the release of an Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets. - Wikipedia:Dense_connective_tissue + @@ -361250,8 +178486,8 @@ The modern definition of neurosecretion has evolved to include the release of an + FMA:75634 - SCTID:363130003 uberon UBERON:0011824 fibrous connective tissue @@ -361260,7 +178496,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -361270,10 +178506,11 @@ The modern definition of neurosecretion has evolved to include the release of an Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue. + + FMA:19783 NCIT:C33007 UMLS:C1253917 - Wikipedia:Loose_connective_tissue textus connectivus collagenosus laxus textus connectivus laxus uberon @@ -361284,7 +178521,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -361303,7 +178540,7 @@ The modern definition of neurosecretion has evolved to include the release of an textus connectivus collagenosus laxus FMA:19783 - FMA:TA + FMA:TA @@ -361311,7 +178548,7 @@ The modern definition of neurosecretion has evolved to include the release of an textus connectivus laxus FMA:19783 - FMA:TA + FMA:TA @@ -361348,7 +178585,7 @@ The modern definition of neurosecretion has evolved to include the release of an An acinus that is part of a exocrine gland. - OBOL:automatic + OBOL:automatic @@ -361356,7 +178593,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -361384,13 +178620,13 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA the FMA class specifically refers to ureter - FMA + FMA @@ -361658,19 +178894,19 @@ The modern definition of neurosecretion has evolved to include the release of an upper part - Wikipedia:Muscular_layer + A muscle layer that is part of a wall of esophagus. - OBOL:automatic + OBOL:automatic In the upper esophagus, part of the externa is skeletal muscle, rather than smooth muscle - WP + WP @@ -361695,7 +178931,7 @@ The modern definition of neurosecretion has evolved to include the release of an tela muscularis (oesophagus) FMA:62998 - FMA:TA + FMA:TA @@ -361708,7 +178944,7 @@ The modern definition of neurosecretion has evolved to include the release of an tunica muscularis oesophageae - FMA:TA + FMA:TA @@ -361762,8 +178998,8 @@ The modern definition of neurosecretion has evolved to include the release of an Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris. + EMAPA:37417 - SCTID:280656002 Haller tunica vascula anterior part of uveal tract anterior uveal tract @@ -361782,7 +179018,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -361793,13 +179029,13 @@ The modern definition of neurosecretion has evolved to include the release of an - MP + MP - lexical + lexical @@ -361811,7 +179047,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37417 - MA:th + MA:th @@ -361859,10 +179095,11 @@ The modern definition of neurosecretion has evolved to include the release of an Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous. The Epimysium also protects muscles from friction against other muscles and bones + + FMA:9726 NCIT:C32527 UMLS:C0504096 - Wikipedia:Epimysium fascia of muscle organ uberon epimysia @@ -361873,7 +179110,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -361884,13 +179121,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous. - Wikipedia:Epimysium + @@ -361908,8 +179145,8 @@ The modern definition of neurosecretion has evolved to include the release of an epimysia - Wikipedia:Epimysium - + + @@ -361961,7 +179198,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -361998,7 +179235,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -362008,10 +179244,11 @@ The modern definition of neurosecretion has evolved to include the release of an A region of the stomach that is lined with glandular epithelium. as currently defined, this would include the cardiac antrum; however, the intent may be to exclude the cardiac glands and in mice for this to be part of the region distal to the margo plicatus + + EMAPA:17623 MA:0001613 NCIT:C77661 - SCTID:27633001 UMLS:C0227197 uberon glandular stomach @@ -362023,7 +179260,7 @@ The modern definition of neurosecretion has evolved to include the release of an A region of the stomach that is lined with glandular epithelium. - http://orcid.org/0000-0002-6601-2165 + @@ -362057,10 +179294,10 @@ The modern definition of neurosecretion has evolved to include the release of an A hepatic vein that is part of a left lobe of liver. + EMAPA:37164 FMA:14339 MA:0003032 - SCTID:55188000 uberon UBERON:0011955 @@ -362070,13 +179307,13 @@ The modern definition of neurosecretion has evolved to include the release of an A hepatic vein that is part of a left lobe of liver. - OBOL:automatic + OBOL:automatic EMAPA:37164 - MA:th + MA:th @@ -362104,10 +179341,10 @@ The modern definition of neurosecretion has evolved to include the release of an A hepatic vein that is part of a right lobe of liver. + EMAPA:37377 FMA:14338 MA:0003034 - SCTID:18135006 uberon UBERON:0011956 @@ -362117,13 +179354,13 @@ The modern definition of neurosecretion has evolved to include the release of an A hepatic vein that is part of a right lobe of liver. - OBOL:automatic + OBOL:automatic EMAPA:37377 - MA:th + MA:th @@ -362164,8 +179401,8 @@ The modern definition of neurosecretion has evolved to include the release of an EHDAA2 distingsuishes between the lumen, the lining, and the 'coelomic cavity', which despire it's name, is not a space - it is the aggregate of space plus lining. coelomic + EHDAA2:0004731 - Wikipedia:Coelom enterocoelom haemocoelom schizocoelom @@ -362179,21 +179416,21 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 The aggregate of the coelemic cavity lumen plus the membranes that line the lumen. - UBERON:cjm - Wikipedia:Body_cavity - Wikipedia:Coelom + + + UBERON:cjm - Wikipedia:Acoelomorpha + @@ -362224,6 +179461,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -362249,17 +179487,17 @@ The modern definition of neurosecretion has evolved to include the release of an The cavity within a myotome. - http://medical-dictionary.thefreedictionary.com/myocoele + The central cavity within the mesoderm is the paired primary or embryonic coelom. Parts of the embryonic coelom often become enclosed in the mesoderm, forming a myocoel within the epimere, a nephrocoel within the mesomere, and simple coelom (body cavity) within the lateral plate mesoderm.[well established][VHOG] - 2012-09-17 + 2012-09-17 VHOG:0001283 - VHOG + VHOG + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.166 and Figure 5.6 - http://bgee.unil.ch/ @@ -362294,6 +179532,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any bone that is part of a palate. this is distinct (but not disjoint) from palatine bone + EMAPA:37930 NCIT:C33248 UMLS:C1518857 @@ -362307,13 +179546,13 @@ The modern definition of neurosecretion has evolved to include the release of an Any bone that is part of a palate. - https://orcid.org/0000-0002-6601-2165 + EMAPA:37930 - MA:th + MA:th @@ -362350,13 +179589,13 @@ The modern definition of neurosecretion has evolved to include the release of an dermatocranium, palatal series - ISBN:0073040584 + ISBN:0073040584 palatal series - ISBN:0073040584 + ISBN:0073040584 @@ -362381,13 +179620,13 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA - ZFA + ZFA @@ -362399,23 +179638,108 @@ The modern definition of neurosecretion has evolved to include the release of an Bone that forms as a replacement of another structural tissue.[TAO] - 2012-08-14 + 2012-08-14 TAO:0001637 - TAO - TAO:wd + TAO + TAO:wd This class was introduced to be consistent with the ZFA hierarchy. The corresponding TAO term was obsoleted, and never introduced into VSAO. Note that VSAO does have replacement element. - ZFA + ZFA replacement bones ZFA:0001628 - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical cavity that is part of a bronchus. + + FMA:62646 + bronchial lumen + lumen of bronchus + uberon + UBERON:0012082 + bronchial lumen + + + + + + + + + + + + + + + + FMA + + + + + + + + + + + FMA + + + + + An anatomical cavity that is part of a bronchus. + OBOL:automatic + + + + + bronchial lumen + FMA:62646 + + + + + lumen of bronchus + FMA:62646 @@ -362423,8 +179747,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -362467,7 +179791,7 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical system that consists of the integumental system plus all mucosae and submucosae. - https://github.com/obophenotype/uberon/issues/53 + @@ -362493,6 +179817,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -362506,6 +179831,7 @@ The modern definition of neurosecretion has evolved to include the release of an A primordium that has the potential to develop into a stomach. + EFO:0002580 NCIT:C34305 UMLS:C1514976 @@ -362519,7 +179845,7 @@ The modern definition of neurosecretion has evolved to include the release of an A primordium that has the potential to develop into a stomach. - OBOL:automatic + OBOL:automatic @@ -362558,6 +179884,7 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a craniocervical region. + EMAPA:37276 MA:0000574 NCIT:C12294 @@ -362570,13 +179897,13 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a craniocervical region. - OBOL:automatic + OBOL:automatic EMAPA:37276 - MA:th + MA:th @@ -362615,6 +179942,7 @@ The modern definition of neurosecretion has evolved to include the release of an The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins. + EMAPA:37180 MA:0002194 NCIT:C53062 @@ -362633,7 +179961,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37180 - MA:th + MA:th @@ -362672,7 +180000,7 @@ The modern definition of neurosecretion has evolved to include the release of an An artery that originates from the abdominal aorta. - SCTID:281470000 + abdominal artery artery of abdomen uberon @@ -362684,8 +180012,8 @@ The modern definition of neurosecretion has evolved to include the release of an An artery that originates from the abdominal aorta. - Wikipedia:Abdominal_aorta#Branches - https://orcid.org/0000-0002-6601-2165 + + @@ -362701,7 +180029,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified]. - Wikipedia:Columnar_epithelium + uberon UBERON:0012274 columnar epithelium @@ -362710,7 +180038,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified]. - Wikipedia:Columnar_epithelium + @@ -362749,7 +180077,7 @@ The modern definition of neurosecretion has evolved to include the release of an Epithelium that derives from the mesoderm. [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -362777,8 +180105,8 @@ The modern definition of neurosecretion has evolved to include the release of an One of five swellings formed during the development of the face. + FMA:293103 - SCTID:89066004 uberon embryonic facial process facial primordium @@ -362790,7 +180118,7 @@ The modern definition of neurosecretion has evolved to include the release of an One of five swellings formed during the development of the face. - http://www.indiana.edu/~anat550/hnanim/face/face.html + @@ -362818,6 +180146,7 @@ The modern definition of neurosecretion has evolved to include the release of an An artery of the neck. + EMAPA:37075 NCIT:C52850 UMLS:C1707349 @@ -362829,13 +180158,13 @@ The modern definition of neurosecretion has evolved to include the release of an An artery of the neck. - https://orcid.org/0000-0002-6601-2165 + EMAPA:37075 - MA:th + MA:th @@ -362867,6 +180196,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + @@ -362875,15 +180210,15 @@ The modern definition of neurosecretion has evolved to include the release of an - + The deep cervical artery (Profunda cervicalis) is an artery of the neck. + + FMA:10659 - SCTID:244223002 - Wikipedia:Deep_cervical_artery uberon profunda cervicalis UBERON:0012321 @@ -362895,23 +180230,23 @@ The modern definition of neurosecretion has evolved to include the release of an - + - FMA + FMA The deep cervical artery (Profunda cervicalis) is an artery of the neck. - Wikipedia:Deep_cervical_artery + profunda cervicalis - Wikipedia:Deep_cervical_artery + @@ -362923,10 +180258,10 @@ The modern definition of neurosecretion has evolved to include the release of an The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery. Unclear if MA class belongs here or in parent + + FMA:10664 MA:0001936 - SCTID:244224008 - Wikipedia:Transverse_cervical_artery uberon cervical artery cervical transverse artery @@ -362943,56 +180278,61 @@ The modern definition of neurosecretion has evolved to include the release of an The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery. - Wikipedia:Transverse_cervical_artery + Unclear if MA class belongs here or in parent - MA + MA + + + + + cervical artery + cervical artery MA:0001936 - Wikipedia:Transverse_cervical_artery cervical transverse artery - Wikipedia:Transverse_cervical_artery + descending branch of the transverse cervical - Wikipedia:Transverse_cervical_artery + transversalis artery colli - Wikipedia:Transverse_cervical_artery + transversalis colli artery - Wikipedia:Transverse_cervical_artery + transverse cervical - Wikipedia:Transverse_cervical_artery + transverse cervical vessels - Wikipedia:Transverse_cervical_artery + @@ -363027,9 +180367,9 @@ The modern definition of neurosecretion has evolved to include the release of an A bone element that is part of a jaw region. Do not manually classify under here - bones are automatically classified + EMAPA:35453 MA:0003130 - SCTID:369003004 jaw bone uberon UBERON:0012360 @@ -363039,7 +180379,7 @@ The modern definition of neurosecretion has evolved to include the release of an A bone element that is part of a jaw region. - OBOL:automatic + OBOL:automatic @@ -363074,7 +180414,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -363124,13 +180464,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A muscle layer that is part of an intestine. - OBOL:automatic + OBOL:automatic @@ -363165,6 +180505,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -363186,11 +180527,12 @@ The modern definition of neurosecretion has evolved to include the release of an A layer of tissue between the muscularis and serosa. + + + FMA:45636 NCIT:C94494 - SCTID:2255006 UMLS:C0225334 - Wikipedia:Subserosa uberon UBERON:0012375 @@ -363201,7 +180543,7 @@ The modern definition of neurosecretion has evolved to include the release of an A layer of tissue between the muscularis and serosa. - Wikipedia:Subserosa + @@ -363246,7 +180588,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37567 - MA:th + MA:th @@ -363285,13 +180627,13 @@ The modern definition of neurosecretion has evolved to include the release of an A smooth muscle tissue that is part of a respiratory system venous blood vessel. - OBOL:automatic + OBOL:automatic EMAPA:37586 - MA:th + MA:th @@ -363310,11 +180652,12 @@ The modern definition of neurosecretion has evolved to include the release of an a wide variety of physiological and cellular functions including absorption, secretion, cellular adhesion, and mechanotransduction increases the surface area of a cell lining whilst minimizing increase in volume FMA class represents an individual microvillus. + + FMA:67296 MESH:D008871 NCIT:C33112 UMLS:C0026049 - Wikipedia:Microvillus uberon microvilli microvillus @@ -363325,14 +180668,14 @@ The modern definition of neurosecretion has evolved to include the release of an A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified]. + GO:0005902 - Wikipedia:Microvillus FMA class represents an individual microvillus. - FMA + FMA @@ -363358,6 +180701,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -363378,14 +180722,14 @@ The modern definition of neurosecretion has evolved to include the release of an A microvillus layer that is striated and found in the intestine. - http://medical-dictionary.thefreedictionary.com/striated+border - http://orcid.org/0000-0002-6601-2165 + + FMA class represents an individual microvillus - FMA + FMA @@ -363426,6 +180770,7 @@ The modern definition of neurosecretion has evolved to include the release of an Blood-forming tissue, consisting of reticular fibers and cells. Bone marrow in humans, kidney interstitium in Danio, within a stroma of reticuloendothelial tissue + CALOHA:TS-2142 FMA:14073 NCIT:C13051 @@ -363443,7 +180788,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -363460,7 +180805,7 @@ The modern definition of neurosecretion has evolved to include the release of an Blood-forming tissue, consisting of reticular fibers and cells. - http://encyclopedia2.thefreedictionary.com/hematopoietic+tissue + @@ -363496,7 +180841,7 @@ The modern definition of neurosecretion has evolved to include the release of an bone marrow tissue - NCBITaxon:9606 + NCBITaxon:9606 @@ -363504,7 +180849,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -363529,9 +180873,9 @@ The modern definition of neurosecretion has evolved to include the release of an The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth. tunica fibrosa + + FMA:58102 - SCTID:361318005 - Wikipedia:Fibrous_tunic_of_eyeball fibrous layer of eyeball uberon corneosclera @@ -363543,19 +180887,19 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth. - Wikipedia:Fibrous_tunic_of_eyeball + - DOI:10.1177/0192623311409597 + @@ -363567,13 +180911,13 @@ The modern definition of neurosecretion has evolved to include the release of an corneosclera - Wikipedia:Fibrous_tunic_of_eyeball + fibrous tunic - Wikipedia:Fibrous_tunic_of_eyeball + @@ -363593,6 +180937,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -363630,13 +180975,13 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm An anatomical space that is enclosed by a cloaca. - OBOL:automatic + OBOL:automatic @@ -363674,6 +181019,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -363692,7 +181038,7 @@ The modern definition of neurosecretion has evolved to include the release of an The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives. - http://orcid.org/0000-0002-6601-2165 + @@ -363712,6 +181058,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -363734,7 +181081,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical space that is enclosed by a terminal part of digestive tract. - OBOL:automatic + OBOL:automatic @@ -363754,6 +181101,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -363773,7 +181121,7 @@ The modern definition of neurosecretion has evolved to include the release of an extraembryonic cavities EHDAA2:0000472 - + @@ -363845,7 +181193,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -363905,13 +181253,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle. - https://orcid.org/0000-0002-6601-2165 + @@ -363923,13 +181271,13 @@ The modern definition of neurosecretion has evolved to include the release of an ossa membri superioris - FMA:TA + FMA:TA pectoral complex skeleton - https://orcid.org/0000-0002-6601-2165 + @@ -363941,7 +181289,7 @@ The modern definition of neurosecretion has evolved to include the release of an skeleton of anterior limb/fin and girdle - https://orcid.org/0000-0002-6601-2165 + @@ -364007,13 +181355,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The collection of all skeletal elements in a pelvic complex - i.e. the combination of free limb or fin plus pelvic girdle. - https://orcid.org/0000-0002-6601-2165 + @@ -364031,13 +181379,13 @@ The modern definition of neurosecretion has evolved to include the release of an ossa membri inferioris - FMA:TA + FMA:TA pelvic complex skeleton - https://orcid.org/0000-0002-6601-2165 + @@ -364049,7 +181397,7 @@ The modern definition of neurosecretion has evolved to include the release of an skeleton of posterior limb/fin and girdle - https://orcid.org/0000-0002-6601-2165 + @@ -364079,10 +181427,10 @@ The modern definition of neurosecretion has evolved to include the release of an The posterior region of the neck, including the suboccipital region. nuchal nape + + BTO:0000957 FMA:24189 - SCTID:182326009 - SCTID:304036007 back of neck nape of neck neck back @@ -364102,7 +181450,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -364113,7 +181461,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -364124,7 +181472,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -364135,7 +181483,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -364195,7 +181543,7 @@ The modern definition of neurosecretion has evolved to include the release of an regio cervicalis posterior - FMA:TA + FMA:TA @@ -364230,7 +181578,7 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that is part of a cloaca. - OBOL:automatic + OBOL:automatic @@ -364250,6 +181598,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -364275,7 +181624,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a cloaca [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -364322,7 +181671,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a cloaca. - http://orcid.org/0000-0002-6601-2165 + @@ -364371,7 +181720,7 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosa that is part of a cloaca [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -364411,7 +181760,7 @@ The modern definition of neurosecretion has evolved to include the release of an A serous membrane that is part of a cloaca [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -364430,6 +181779,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -364446,7 +181796,7 @@ The modern definition of neurosecretion has evolved to include the release of an cloacal villi - + @@ -364483,7 +181833,7 @@ The modern definition of neurosecretion has evolved to include the release of an A muscular coat that is part of a cloaca. - OBOL:automatic + OBOL:automatic @@ -364510,8 +181860,8 @@ The modern definition of neurosecretion has evolved to include the release of an A muscular coat that is part of a duodenum. + FMA:14944 - SCTID:362147007 duodenal muscularis propria muscularis externa of duodenum uberon @@ -364524,7 +181874,7 @@ The modern definition of neurosecretion has evolved to include the release of an A muscular coat that is part of a duodenum. - OBOL:automatic + OBOL:automatic @@ -364542,13 +181892,13 @@ The modern definition of neurosecretion has evolved to include the release of an muscularis propria of duodenum - https://orcid.org/0000-0002-6601-2165 + smooth muscle of duodenum - https://orcid.org/0000-0002-6601-2165 + @@ -364576,10 +181926,10 @@ The modern definition of neurosecretion has evolved to include the release of an A muscular coat that is part of a colon. + EMAPA:27383 FMA:14986 MA:0003198 - SCTID:362158003 colonic muscularis propria muscular coat of colon muscular layer of colon @@ -364595,7 +181945,7 @@ The modern definition of neurosecretion has evolved to include the release of an A muscular coat that is part of a colon. - OBOL:automatic + OBOL:automatic @@ -364625,7 +181975,7 @@ The modern definition of neurosecretion has evolved to include the release of an tunica muscularis coli - FMA:TA + FMA:TA @@ -364659,8 +182009,8 @@ The modern definition of neurosecretion has evolved to include the release of an A muscular coat that is part of a anal canal. + FMA:15708 - SCTID:362171000 anal canal muscularis propria anal muscularis propria muscular coat of anal canal @@ -364675,7 +182025,7 @@ The modern definition of neurosecretion has evolved to include the release of an A muscular coat that is part of a anal canal. - OBOL:automatic + OBOL:automatic @@ -364706,6 +182056,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -364714,8 +182065,8 @@ The modern definition of neurosecretion has evolved to include the release of an An adventitia that is part of a esophagus. + FMA:63006 - SCTID:85950006 adventitia of oesophagus adventitious layer of esophagus esophageal adventitia @@ -364730,7 +182081,7 @@ The modern definition of neurosecretion has evolved to include the release of an An adventitia that is part of a esophagus. - OBOL:automatic + OBOL:automatic @@ -364766,7 +182117,7 @@ The modern definition of neurosecretion has evolved to include the release of an tunica adventitia oesophageae - FMA:TA + FMA:TA @@ -364789,6 +182140,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -364809,8 +182161,8 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical junction that connects a stomach and connects a duodenum. + FMA:17046 - SCTID:264014000 uberon UBERON:0012650 gastroduodenal junction @@ -364819,7 +182171,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical junction that connects a stomach and connects a duodenum. - OBOL:automatic + OBOL:automatic @@ -364862,7 +182214,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a gastroduodenal junction. - OBOL:automatic + OBOL:automatic @@ -364898,7 +182250,7 @@ The modern definition of neurosecretion has evolved to include the release of an A vein that is part of a abdomen. TODO mirror representation of abdominal aorta this class groups all veins that are in the abdomen. The term 'abdominal vein' may have specific meanings in different contexts. The lateral abdominal veins are present in fishes but usually merged or absent in tetrapods; in amphibians, the L&R abdominal veins merge into the ventral abdominal vein - SCTID:281473003 + abdominal vein uberon UBERON:0013126 @@ -364909,47 +182261,7 @@ The modern definition of neurosecretion has evolved to include the release of an A vein that is part of a abdomen. - OBOL:automatic - - - - - - - - - - - - - - - - - - - - - The part of the venous system that drains the lungs[Kardong]. - Pulmonary circulation is the half portion of the cardiovascular system which carries oxygen-depleted blood away from the heart, to the lungs, and returns oxygenated (oxygen-rich) blood back to the heart. The term pulmonary circulation is readily paired and contrasted with the systemic circulation. A separate system known as the bronchial circulation supplies blood to the tissue of the larger airways of the lung. - Wikipedia:Pulmonary_venous_system - pulmonary venous circulatory system - uberon - UBERON:0013127 - pulmonary venous system - - - - - The part of the venous system that drains the lungs[Kardong]. - ISBN:0073040584 - Wikipedia:Pulmonary_venous_system - - - - - Pulmonary circulation is the half portion of the cardiovascular system which carries oxygen-depleted blood away from the heart, to the lungs, and returns oxygenated (oxygen-rich) blood back to the heart. The term pulmonary circulation is readily paired and contrasted with the systemic circulation. A separate system known as the bronchial circulation supplies blood to the tissue of the larger airways of the lung. - Wikipedia:Pulmonary_circulation + OBOL:automatic @@ -364988,7 +182300,7 @@ The modern definition of neurosecretion has evolved to include the release of an A vein that drains a lip. - SCTID:367664002 + labial vein of face lip vein vena labialis @@ -365006,19 +182318,19 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A vein that drains a lip. - OBOL:automatic + OBOL:automatic lip vein - OBOL:automatic + OBOL:automatic @@ -365051,9 +182363,10 @@ The modern definition of neurosecretion has evolved to include the release of an Any vein within the general circulation that transports blood back to the right atrium of the heart. + + FMA:66644 NCIT:C33719 - SCTID:244389004 UMLS:C0447117 systemic venous tree organ part uberon @@ -365114,7 +182427,7 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that is part of a foregut-midgut junction. - OBOL:automatic + OBOL:automatic @@ -365163,8 +182476,8 @@ The modern definition of neurosecretion has evolved to include the release of an The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells. - http://orcid.org/0000-0002-6601-2165 - http://www.siumed.edu/~dking2/intro/glands.htm + + @@ -365197,13 +182510,14 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical cavity that is the lumen of the skull and contains the brain. + + + EMAPA:37497 FMA:9644 MA:0003061 NCIT:C77638 - SCTID:264452006 UMLS:C0230041 - Wikipedia:Cranial_cavity neuronames:2806 cavitas cranii uberon @@ -365211,7 +182525,7 @@ The modern definition of neurosecretion has evolved to include the release of an intracranial space UBERON:0013411 cranial cavity - http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg + http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg @@ -365222,19 +182536,19 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia Anatomical cavity that is the lumen of the skull and contains the brain. - UBERON:cjm + UBERON:cjm EMAPA:37497 - MA:th + MA:th @@ -365247,20 +182561,20 @@ The modern definition of neurosecretion has evolved to include the release of an cavitas cranii FMA:9644 - FMA:TA + FMA:TA intracranial cavity - Wikipedia:Cranial_cavity + intracranial space - Wikipedia:Cranial_cavity + @@ -365300,7 +182614,7 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel endothelium that is part of a lung [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -365334,6 +182648,7 @@ The modern definition of neurosecretion has evolved to include the release of an A sphincter muscle that is part of a cloaca. + NCIT:C34129 UMLS:C1516658 sphincter cloacae @@ -365346,7 +182661,7 @@ The modern definition of neurosecretion has evolved to include the release of an A sphincter muscle that is part of a cloaca. - OBOL:automatic + OBOL:automatic @@ -365358,7 +182673,7 @@ The modern definition of neurosecretion has evolved to include the release of an sphincter cloacae - + @@ -365419,13 +182734,13 @@ The modern definition of neurosecretion has evolved to include the release of an A caudal vertebra endochondral element that is composed primarily of cartilage tissue. - OBOL:automatic + OBOL:automatic coccygeal vertebra cartilage element - http://orcid.org/0000-0002-6601-2165 + @@ -365483,13 +182798,13 @@ The modern definition of neurosecretion has evolved to include the release of an A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation. - OBOL:automatic + OBOL:automatic coccygeal vertebra pre-cartilage condensation - http://orcid.org/0000-0002-6601-2165 + @@ -365547,7 +182862,7 @@ The modern definition of neurosecretion has evolved to include the release of an A cervical vertebra endochondral element that is composed primarily of cartilage tissue. - OBOL:automatic + OBOL:automatic @@ -365589,7 +182904,7 @@ The modern definition of neurosecretion has evolved to include the release of an A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation. - OBOL:automatic + OBOL:automatic @@ -365646,7 +182961,7 @@ The modern definition of neurosecretion has evolved to include the release of an A thoracic vertebra endochondral element that is composed primarily of cartilage tissue. - OBOL:automatic + OBOL:automatic @@ -365694,7 +183009,7 @@ The modern definition of neurosecretion has evolved to include the release of an A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation. - OBOL:automatic + OBOL:automatic @@ -365731,7 +183046,7 @@ The modern definition of neurosecretion has evolved to include the release of an The space that surrounds an organism. - https://orcid.org/0000-0002-6601-2165 + @@ -365786,6 +183101,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -365823,13 +183139,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA The anatomical space that is enclosed by a stomach. - http://orcid.org/0000-0002-6601-2165 + @@ -365897,13 +183213,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA An epithelium that is part of a intestinal villus. - OBOL:automatic + OBOL:automatic @@ -365936,9 +183252,9 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical space that is an opening in a bone of the skull. + + FMA:53165 - SCTID:276742007 - Wikipedia:Foramina_of_the_skull foramen of skull cranial conduit cranial foramen @@ -365951,14 +183267,14 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical space that is an opening in a bone of the skull. - TAO:curator - http://orcid.org/0000-0002-6601-2165 + + TAO:curator foramen of skull - Wikipedia:Foramina_of_the_skull + @@ -365970,8 +183286,8 @@ The modern definition of neurosecretion has evolved to include the release of an foramina of the skull - Wikipedia:Foramina_of_the_skull - + + @@ -366000,28 +183316,24 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]. - - - FMA:9338 foramen space uberon UBERON:0013686 - anatomical conduit space - FMA + FMA An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]. + FMA:9338 - http://orcid.org/0000-0002-6601-2165 @@ -366274,7 +183586,7 @@ The modern definition of neurosecretion has evolved to include the release of an A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages. - https://orcid.org/0000-0002-6601-2165 + @@ -366290,7 +183602,6 @@ The modern definition of neurosecretion has evolved to include the release of an The region of the organism associated with the visceral organs. - Cardinal body part, which consists of a maximal set of diverse subclasses of organ and organ part spatially associated with the vertebral column and ribcage. Examples: There is only one body proper[FMA:231424]. AEO:0000103 BTO:0001489 @@ -366300,7 +183611,6 @@ The modern definition of neurosecretion has evolved to include the release of an body whole body UBERON:0013702 - body proper @@ -366308,7 +183618,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -366360,6 +183670,7 @@ The modern definition of neurosecretion has evolved to include the release of an A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily. + FMA:293127 NCIT:C34230 UMLS:C1518428 @@ -366372,7 +183683,7 @@ The modern definition of neurosecretion has evolved to include the release of an A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily. - http://medical-dictionary.thefreedictionary.com/notochordal+canal + @@ -366401,6 +183712,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -366426,8 +183738,8 @@ The modern definition of neurosecretion has evolved to include the release of an Fluid contained within the notochordal canal. - http://animaldiversity.org/accounts/Latimeria_chalumnae/ - http://orcid.org/0000-0002-6601-2165 + + @@ -366454,7 +183766,7 @@ The modern definition of neurosecretion has evolved to include the release of an An organ component layer that is part of a integumental system. - SCTID:314820002 + layer of skin skin layer uberon @@ -366466,7 +183778,7 @@ The modern definition of neurosecretion has evolved to include the release of an An organ component layer that is part of a integumental system. - OBOL:automatic + OBOL:automatic @@ -366493,7 +183805,6 @@ The modern definition of neurosecretion has evolved to include the release of an A blood that is part of a artery. - BTO:0006188 FMA:83066 arterial blood blood in artery @@ -366507,13 +183818,7 @@ The modern definition of neurosecretion has evolved to include the release of an A blood that is part of a artery. - OBOL:automatic - - - - - BTO:0006188 - https://orcid.org/0000-0003-4423-4370 + OBOL:automatic @@ -366558,7 +183863,6 @@ The modern definition of neurosecretion has evolved to include the release of an A blood that is part of a vein. - BTO:0006187 FMA:83067 blood in vein portion of venous blood @@ -366571,13 +183875,7 @@ The modern definition of neurosecretion has evolved to include the release of an A blood that is part of a vein. - OBOL:automatic - - - - - BTO:0006187 - https://orcid.org/0000-0003-4423-4370 + OBOL:automatic @@ -366635,7 +183933,7 @@ The modern definition of neurosecretion has evolved to include the release of an A blood that is part of a capillary. - OBOL:automatic + OBOL:automatic @@ -366668,8 +183966,8 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements. + EMAPA:37843 - SCTID:272627002 digestive organ digestive system organ uberon @@ -366682,13 +183980,13 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements. - http://orcid.org/0000-0002-6601-2165 + EMAPA:37843 - MA:th + MA:th @@ -366699,9 +183997,9 @@ The modern definition of neurosecretion has evolved to include the release of an Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart. great vessel + + EMAPA:36460 - SCTID:304066000 - Wikipedia:Great_vessels great vessel of thorax uberon UBERON:0013768 @@ -366713,7 +184011,7 @@ The modern definition of neurosecretion has evolved to include the release of an Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart. - Wikipedia:Great_vessels + @@ -366754,8 +184052,8 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that develops_from the neural crest[Automatically generated definition]. - OBOL:automatic - https://github.com/obophenotype/uberon/issues/248 + + OBOL:automatic @@ -366805,7 +184103,7 @@ The modern definition of neurosecretion has evolved to include the release of an Muscle that is part of the respiratory system. - http://orcid.org/0000-0002-6601-2165 + @@ -366849,7 +184147,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical space that is enclosed by a sinusoid. - OBOL:automatic + OBOL:automatic @@ -366898,7 +184196,7 @@ The modern definition of neurosecretion has evolved to include the release of an A sinusoidal space that is part of a hepatic sinusoid. - OBOL:automatic + OBOL:automatic @@ -366909,90 +184207,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - A part of the body present only in a specific gender. - AEO:0000174 - WBbt:0005752 - gender-specific - gender-specific anatomical structure - sex-specific - uberon - UBERON:0014402 - sex-specific anatomical structure - - - - - A part of the body present only in a specific gender. - AEO:0000174 - AEO:JB - - - - - gender-specific anatomical structure - AEO:0000174 - - - - - - - - - - - - - - - - - - - - - - - - - - A part of the body present only in females. - AEO:0000176 - uberon - UBERON:0014404 - female anatomical structure - - - - - A part of the body present only in females. - AEO:0000176 - AEO:JB - - - - @@ -367061,10 +184275,10 @@ The modern definition of neurosecretion has evolved to include the release of an Subcutaneous adipose tissue that is located in the peritoneal cavity. + + CALOHA:paula - MGI:csmith - http://orcid.org/0000-0002-6601-2165 - https://github.com/obophenotype/uberon/issues/259 + MGI:csmith @@ -367153,10 +184367,10 @@ The modern definition of neurosecretion has evolved to include the release of an Subcutaneous adipose tissue that is located in the abdominal region. + + CALOHA:paula - MGI:csmith - http://orcid.org/0000-0002-6601-2165 - https://github.com/obophenotype/uberon/issues/259 + MGI:csmith @@ -367164,6 +184378,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -367178,16 +184393,14 @@ The modern definition of neurosecretion has evolved to include the release of an Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum. - + EHDAA2:0002013 FMA:77169 - Wikipedia:Thoracic_skeleton skeleton of thorax thoracic part of axial skeleton thoracic skeleton uberon UBERON:0014477 - thoracic skeleton @@ -367195,8 +184408,8 @@ The modern definition of neurosecretion has evolved to include the release of an Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum. - Wikipedia:Rib_cage - https://orcid.org/0000-0002-6601-2165 + + @@ -367207,74 +184420,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - A ventral horn of spinal cord that is part of a thoracic spinal cord. - - BIRNLEX:1410 - SCTID:367876000 - UMLS:C0228632 - UMLS:C1288552 - thoracic spinal cord ventral horn - uberon - thoracic spinal cord anterior horn - UBERON:0014610 - - thoracic spinal cord ventral horn - - - - - A ventral horn of spinal cord that is part of a thoracic spinal cord. - OBOL:automatic - - - - - UMLS:C0228632 - BIRNLEX:1410 - - - - - UMLS:C1288552 - BIRNLEX:1410 - - - - - thoracic spinal cord ventral horn - BIRNLEX:1410 - - - - - - thoracic spinal cord anterior horn - BIRNLEX:1410 - - - - @@ -367297,21 +184442,20 @@ The modern definition of neurosecretion has evolved to include the release of an A gray matter of spinal cord that is part of a cervical spinal cord. - + + BIRNLEX:1521 - SCTID:362438009 UMLS:C0228610 cervical spinal cord gray matter uberon UBERON:0014613 - cervical spinal cord gray matter A gray matter of spinal cord that is part of a cervical spinal cord. - OBOL:automatic + OBOL:automatic @@ -367329,74 +184473,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - A ventral horn of spinal cord that is part of a cervical spinal cord. - - BIRNLEX:1680 - SCTID:174363005 - UMLS:C0228615 - UMLS:C1278740 - cervical spinal cord ventral horn - uberon - cervical spinal cord anterior horn - UBERON:0014621 - - cervical spinal cord ventral horn - - - - - A ventral horn of spinal cord that is part of a cervical spinal cord. - OBOL:automatic - - - - - UMLS:C0228615 - BIRNLEX:1680 - - - - - UMLS:C1278740 - BIRNLEX:1680 - - - - - cervical spinal cord ventral horn - BIRNLEX:1680 - - - - - - cervical spinal cord anterior horn - BIRNLEX:1680 - - - - @@ -367419,21 +184495,20 @@ The modern definition of neurosecretion has evolved to include the release of an A gray matter of spinal cord that is part of a thoracic spinal cord. - + + BIRNLEX:980 - SCTID:362441000 UMLS:C0228627 thoracic spinal cord gray matter uberon UBERON:0014636 - thoracic spinal cord gray matter A gray matter of spinal cord that is part of a thoracic spinal cord. - OBOL:automatic + OBOL:automatic @@ -367491,7 +184566,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -367502,13 +184577,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 An epithelium that is part of a frontonasal prominence. - OBOL:automatic + OBOL:automatic @@ -367556,7 +184631,7 @@ The modern definition of neurosecretion has evolved to include the release of an A unilaminar epithelium that develops_from a ectoderm and is part of a anal region. - OBOL:automatic + OBOL:automatic @@ -367576,6 +184651,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -367611,13 +184687,13 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 An anatomical space that is enclosed by a pleuroperitoneal canal. - OBOL:automatic + OBOL:automatic @@ -367667,9 +184743,9 @@ The modern definition of neurosecretion has evolved to include the release of an A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory. + + NCIT:C32828 - UMLS:C1512857 - Wikipedia:Interlobular_ducts uberon UBERON:0014716 @@ -367723,8 +184799,8 @@ The modern definition of neurosecretion has evolved to include the release of an The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells. - http://orcid.org/0000-0002-6601-2165 - http://www.siumed.edu/~dking2/intro/glands.htm + + @@ -367752,7 +184828,7 @@ The modern definition of neurosecretion has evolved to include the release of an A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular. - SCTID:205214009 + uberon intralobular ductule UBERON:0014719 @@ -367763,7 +184839,7 @@ The modern definition of neurosecretion has evolved to include the release of an A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular. - http://www.siumed.edu/~dking2/intro/glands.htm + @@ -367809,7 +184885,7 @@ The modern definition of neurosecretion has evolved to include the release of an A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory. - http://www.siumed.edu/~dking2/intro/glands.htm + @@ -367818,6 +184894,13 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + @@ -367843,11 +184926,11 @@ The modern definition of neurosecretion has evolved to include the release of an The domain of the diaphragm that is located dorsally and attaches to the vertebrae and surrounds the esophagus and aorta. + + EHDAA2:0000597 EMAPA:17703 - SCTID:244668003 VHOG:0001546 - Wikipedia:Crus_of_diaphragm crural diaphragm uberon crura of the diaphragm @@ -367867,7 +184950,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:23586979 + @@ -367878,43 +184961,43 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:23586979 + The domain of the diaphragm that is located dorsally and attaches to the vertebrae and surrounds the esophagus and aorta. - PMID:23586979 + crural diaphragm - PMID:23586979 + crura of the diaphragm - Wikipedia:Crus_of_diaphragm + crus of the diaphragm - Wikipedia:Crus_of_diaphragm + diaphragm crura - + diaphragmatic crura - Wikipedia:Crus_of_diaphragm + @@ -367943,8 +185026,8 @@ The modern definition of neurosecretion has evolved to include the release of an A crus of diaphragm that is in_the_right_side_of a diaphragm. https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern + FMA:58286 - SCTID:362690009 crus dextrum (Diaphragma) crus dextrum diaphragmatis external sphincter of esophagus @@ -367958,14 +185041,14 @@ The modern definition of neurosecretion has evolved to include the release of an A crus of diaphragm that is in_the_right_side_of a diaphragm. - OBOL:automatic + OBOL:automatic crus dextrum (Diaphragma) FMA:58286 - FMA:TA + FMA:TA @@ -367973,7 +185056,7 @@ The modern definition of neurosecretion has evolved to include the release of an crus dextrum diaphragmatis FMA:58286 - FMA:TA + FMA:TA @@ -368021,8 +185104,8 @@ The modern definition of neurosecretion has evolved to include the release of an A crus of diaphragm that is in_the_left_side_of a diaphragm. https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern + FMA:58287 - SCTID:244937004 crus sinistrum (Diaphragma) crus sinistrum diaphragmatis left crus of diaphragm @@ -368035,14 +185118,14 @@ The modern definition of neurosecretion has evolved to include the release of an A crus of diaphragm that is in_the_left_side_of a diaphragm. - OBOL:automatic + OBOL:automatic crus sinistrum (Diaphragma) FMA:58287 - FMA:TA + FMA:TA @@ -368050,7 +185133,7 @@ The modern definition of neurosecretion has evolved to include the release of an crus sinistrum diaphragmatis FMA:58287 - FMA:TA + FMA:TA @@ -368107,7 +185190,7 @@ The modern definition of neurosecretion has evolved to include the release of an A neuromere that is part of the presumptive midbrain. - http://orcid.org/0000-0002-6601-2165 + @@ -368153,14 +185236,14 @@ The modern definition of neurosecretion has evolved to include the release of an A neuromere that is part of the presumptive spinal cord. - http://orcid.org/0000-0002-6601-2165 + spinal neuromeres TAO:0001332 - + @@ -368202,7 +185285,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any muscle organ that is part of a cloaca. - OBOL:automatic + OBOL:automatic @@ -368243,13 +185326,13 @@ The modern definition of neurosecretion has evolved to include the release of an Any collection of muscles that is part of a pelvic complex. The pelvic complex comprises the pelvic girdle and the associated limb or fin. - OBOL:automatic + OBOL:automatic EMAPA:37864 - MA:th + MA:th @@ -368267,7 +185350,7 @@ The modern definition of neurosecretion has evolved to include the release of an musculi membri inferioris - FMA:TA + FMA:TA @@ -368310,13 +185393,13 @@ The modern definition of neurosecretion has evolved to include the release of an Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin. - OBOL:automatic + OBOL:automatic EMAPA:37861 - MA:th + MA:th @@ -368334,7 +185417,7 @@ The modern definition of neurosecretion has evolved to include the release of an musculi membri superioris - FMA:TA + FMA:TA @@ -368392,13 +185475,13 @@ The modern definition of neurosecretion has evolved to include the release of an - prolog + prolog Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin). - OBOL:automatic + OBOL:automatic @@ -368444,13 +185527,13 @@ The modern definition of neurosecretion has evolved to include the release of an - prolog + prolog Any muscle organ that is part of a pelvic appendage (hindlimb or pelvic fin). - OBOL:automatic + OBOL:automatic @@ -368462,10 +185545,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - @@ -368478,34 +185557,20 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + - - - - - - - - - - - - - - - - - - @@ -368524,6 +185589,12 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles). skeletal muscle AAO:0011099 @@ -368541,19 +185612,20 @@ The modern definition of neurosecretion has evolved to include the release of an MAT:0000302 MESH:D018482 MIAA:0000302 + OpenCyc:Mx4rv2kf-5wpEbGdrcN5Y29ycA TAO:0005277 VHOG:0000319 XAO:0000174 ZFA:0005277 uberon UBERON:0014892 - skeletal muscle organ, vertebrate + skeletal muscle organ A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles). - GOC:dos + GOC:dos @@ -368573,6 +185645,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -368634,7 +185707,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA @@ -368645,13 +185718,13 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA + ZFA One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites. - MGI:anna + MGI:anna @@ -368663,7 +185736,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37389 - MA:th + MA:th @@ -368676,7 +185749,7 @@ The modern definition of neurosecretion has evolved to include the release of an intersegmental vessels ZFA:0001285 - + @@ -368689,7 +185762,7 @@ The modern definition of neurosecretion has evolved to include the release of an intersomitic vessels ZFA:0001285 - + @@ -368742,19 +185815,19 @@ The modern definition of neurosecretion has evolved to include the release of an A vertebral endochondral element in the cervical region of the vertebral column. - http://orcid.org/0000-0002-6601-2165 + cervical vertebra skeletal element - https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern + cervical vertebra element - https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern + @@ -368802,19 +185875,19 @@ The modern definition of neurosecretion has evolved to include the release of an A vertebral endochondral element in the thoracic region of the vertebral column. - http://orcid.org/0000-0002-6601-2165 + thoracic vertebra skeletal element - https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern + thoracic vertebra element - https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern + @@ -368850,19 +185923,19 @@ The modern definition of neurosecretion has evolved to include the release of an A sphenoid bone or its cartilage or pre-cartilage precursor. - https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern + sphenoid bone skeletal element - https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern + sphenoid element - https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern + @@ -368890,7 +185963,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -368901,7 +185974,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -368974,8 +186047,8 @@ The modern definition of neurosecretion has evolved to include the release of an Visceral intrapericardial fat contiguous with the myocardial surface. + FMA:9871 - SCTID:42267001 epicardial adipose tissue pericardial adipose tissue uberon @@ -368986,7 +186059,7 @@ The modern definition of neurosecretion has evolved to include the release of an Visceral intrapericardial fat contiguous with the myocardial surface. - DOI:10.5935/abc.20130138 + @@ -369043,8 +186116,8 @@ The modern definition of neurosecretion has evolved to include the release of an A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands. - http://orcid.org/0000-0002-6601-2165 - https://github.com/obophenotype/uberon/issues/614 + + @@ -369099,29 +186172,29 @@ The modern definition of neurosecretion has evolved to include the release of an An eye consisting of multiple light-sensing organs. - PMID:21062451 - http://orcid.org/0000-0002-6601-2165 + + present on tentacular crown - PMID:21062451 + present on mantle edge in arcacean Bivalvia - PMID:21062451 + The eyes (optic cushions) on the oral surface of Asteroida (Echinodermata), close to the base of the terminal tentacles, are also composed of a number of simple ocelli - as many as 80-200 in certain species - PMID:21062451 + @@ -369144,6 +186217,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -369176,7 +186250,7 @@ The modern definition of neurosecretion has evolved to include the release of an A region of somite adjacent to presomitic mesoderm. - http://orcid.org/0000-0002-6601-2165 + @@ -369208,6 +186282,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -369244,65 +186319,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - An anatomical group whose component structures share a common function. - AEO:0000093 - FBbt:00007278 - uberon - UBERON:0015203 - non-connected functional system - - - - - An anatomical group whose component structures share a common function. - AEO:0000093 - AEO:JB - FBC:DOS - FBbt:00007278 - - - - - - - - - - - - - - - - - - - - - - - - - - A non-connected functional system that is composed primarily of a gland. - EHDAA2:0002223 - uberon - UBERON:0015204 - glandular system - - - - - A non-connected functional system that is composed primarily of a gland. - OBOL:automatic - - - - @@ -369348,7 +186364,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any structure that is placed on one side of the left-right axis of a bilaterian. - http://orcid.org/0000-0002-6601-2165 + @@ -369385,7 +186401,7 @@ The modern definition of neurosecretion has evolved to include the release of an A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile. - http://orcid.org/0000-0002-6601-2165 + @@ -369423,13 +186439,13 @@ The modern definition of neurosecretion has evolved to include the release of an A pancreatic lobule that is in_the_left_side_of a exocrine pancreas. - OBOL:automatic + OBOL:automatic EMAPA:37711 - MA:th + MA:th @@ -369467,13 +186483,13 @@ The modern definition of neurosecretion has evolved to include the release of an A pancreatic lobule that is in_the_right_side_of a exocrine pancreas. - OBOL:automatic + OBOL:automatic EMAPA:37712 - MA:th + MA:th @@ -369521,19 +186537,19 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA A basement membrane of epithelium that is part of a respiratory system. - OBOL:automatic + OBOL:automatic EMAPA:37570 - MA:th + MA:th @@ -369548,26 +186564,24 @@ The modern definition of neurosecretion has evolved to include the release of an - EMAPA:37597 MA:0002449 heart/pericardium uberon UBERON:0015410 - heart plus pericardium - MA + MA EMAPA:37597 - MA:th + MA:th @@ -369582,19 +186596,26 @@ The modern definition of neurosecretion has evolved to include the release of an + - + + + + + + + The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery. + + EMAPA:37217 FMA:14772 MA:0003095 - SCTID:244262006 - Wikipedia:Hepatic_artery_proper hepatic artery proper uberon proper hepatic @@ -369606,30 +186627,30 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA - + - FMA + FMA The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery. - Wikipedia:Hepatic_artery_proper + EMAPA:37217 - MA:th + MA:th @@ -369641,7 +186662,7 @@ The modern definition of neurosecretion has evolved to include the release of an proper hepatic - Wikipedia:Hepatic_artery_proper + @@ -369696,19 +186717,19 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A hepatic artery that is part of a left lobe of liver. - OBOL:automatic + OBOL:automatic EMAPA:37096 - MA:th + MA:th @@ -369727,7 +186748,7 @@ The modern definition of neurosecretion has evolved to include the release of an ramus sinister (arteria hepatica propria) FMA:14779 - FMA:TA + FMA:TA @@ -369783,26 +186804,26 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A hepatic artery that is part of a right lobe of liver. - OBOL:automatic + OBOL:automatic EMAPA:37376 - MA:th + MA:th ramus dexter (arteria hepatica propria) FMA:14778 - FMA:TA + FMA:TA @@ -369863,13 +186884,13 @@ The modern definition of neurosecretion has evolved to include the release of an Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla. - http://medical-dictionary.thefreedictionary.com/choledochoduodenal+junction + EMAPA:37478 - MA:th + MA:th @@ -369917,7 +186938,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a anal canal. - OBOL:automatic + OBOL:automatic @@ -369948,7 +186969,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -369992,7 +187013,7 @@ The modern definition of neurosecretion has evolved to include the release of an A smooth muscle tissue that is part of a hypodermis. - OBOL:automatic + OBOL:automatic @@ -370005,7 +187026,7 @@ The modern definition of neurosecretion has evolved to include the release of an stratum musculosum panniculi adiposi telae subcutaneae FMA:77862 - FMA:TA + FMA:TA @@ -370045,7 +187066,7 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel that is part of a liver. - OBOL:automatic + OBOL:automatic @@ -370089,7 +187110,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a camera-type eye. - OBOL:automatic + OBOL:automatic @@ -370126,7 +187147,7 @@ The modern definition of neurosecretion has evolved to include the release of an An epithelium that is part of a foregut. - OBOL:automatic + OBOL:automatic @@ -370186,13 +187207,13 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA A lamina propria that is part of a duodenum. - OBOL:automatic + OBOL:automatic @@ -370238,12 +187259,10 @@ The modern definition of neurosecretion has evolved to include the release of an A capillary that is part of a lung. - FMA:14121 capillary of lung uberon UBERON:0016405 - pulmonary capillary @@ -370251,7 +187270,7 @@ The modern definition of neurosecretion has evolved to include the release of an A capillary that is part of a lung. - OBOL:automatic + OBOL:automatic @@ -370274,13 +187293,14 @@ The modern definition of neurosecretion has evolved to include the release of an - + + @@ -370289,7 +187309,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -370366,7 +187386,7 @@ The modern definition of neurosecretion has evolved to include the release of an A stroma that is part of a liver. - OBOL:automatic + OBOL:automatic @@ -370412,13 +187432,15 @@ The modern definition of neurosecretion has evolved to include the release of an Is the sensory system for the sense of hearing. Auditory system is general anatomical term in FMA + + EMAPA:36002 FMA:7192 MA:0002443 NCIT:C12889 NLXANAT:090817 + OpenCyc:Mx4rvViwtJwpEbGdrcN5Y29ycA UMLS:C0587901 - Wikipedia:Auditory_system neuronames:2888 uberon UBERON:0016490 @@ -370434,7 +187456,7 @@ The modern definition of neurosecretion has evolved to include the release of an Auditory system is general anatomical term in FMA - FMA + FMA @@ -370485,7 +187507,7 @@ The modern definition of neurosecretion has evolved to include the release of an Luminal space of the right ventricle of the heart. - http://orcid.org/0000-0002-6601-2165 + @@ -370497,7 +187519,7 @@ The modern definition of neurosecretion has evolved to include the release of an right ventricular cavity - FMA:FMA + FMA:FMA @@ -370517,6 +187539,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -370536,19 +187559,19 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical space that is part of a duodenum. - OBOL:automatic + OBOL:automatic doudenal lumen - FMA:FMA + FMA:FMA duodenal lumen - FMA:FMA + FMA:FMA @@ -370593,13 +187616,13 @@ The modern definition of neurosecretion has evolved to include the release of an Luminal space of the left atrium of the heart. - http://orcid.org/0000-0002-6601-2165 + left atrial cavity - FMA:FMA + FMA:FMA @@ -370649,13 +187672,13 @@ The modern definition of neurosecretion has evolved to include the release of an Luminal space of the left ventricle of the heart. - http://orcid.org/0000-0002-6601-2165 + left ventricular cavity - FMA:FMA + FMA:FMA @@ -370699,13 +187722,13 @@ The modern definition of neurosecretion has evolved to include the release of an Luminal space of the right atrium of the heart. - http://orcid.org/0000-0002-6601-2165 + right atrial cavity - FMA:FMA + FMA:FMA @@ -370755,8 +187778,8 @@ The modern definition of neurosecretion has evolved to include the release of an The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches. - PMID:23020903 - http://orcid.org/0000-0002-6601-2165 + + @@ -370797,7 +187820,7 @@ The modern definition of neurosecretion has evolved to include the release of an A layer of of the central nervous system that is part of gray matter. - http://orcid.org/0000-0002-6601-2165 + @@ -370808,23 +187831,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - uberon - UBERON:0016550 - spinal cord column - - - - @@ -370847,8 +187853,8 @@ The modern definition of neurosecretion has evolved to include the release of an Mucus produced in the respiratory tract. + NCIT:C93171 - UMLS:C0225378 uberon UBERON:0016552 phlegm @@ -370857,7 +187863,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mucus produced in the respiratory tract. - http://orcid.org/0000-0002-6601-2165 + @@ -370892,8 +187898,8 @@ The modern definition of neurosecretion has evolved to include the release of an Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm). - Wikipedia:Nasal_mucus#Respiratory_system - http://orcid.org/0000-0002-6601-2165 + + @@ -370941,9 +187947,9 @@ The modern definition of neurosecretion has evolved to include the release of an + + FMA:68861 - Wikipedia:Rexed_laminae - http://neurolex.org/wiki/Category:Rexed_spinal_cord_parcellation_scheme_region rexed lamina uberon UBERON:0016570 @@ -370997,19 +188003,19 @@ The modern definition of neurosecretion has evolved to include the release of an The dorsal region of the optic cup that gives rise to the dorsal part of the retina. - http://orcid.org/0000-0002-6601-2165 + dorsal optic cup - http://orcid.org/0000-0002-6601-2165 + dorsal region of optic cup - http://orcid.org/0000-0002-6601-2165 + @@ -371059,7 +188065,7 @@ The modern definition of neurosecretion has evolved to include the release of an Primordium that develops into the central nervous system. - http://orcid.org/0000-0002-6601-2165 + @@ -371109,7 +188115,7 @@ The modern definition of neurosecretion has evolved to include the release of an Primordium that develops into the nervous system. - http://orcid.org/0000-0002-6601-2165 + @@ -371153,7 +188159,7 @@ The modern definition of neurosecretion has evolved to include the release of an Epithelium lining the distalmost portion of the digestive tract. - http://orcid.org/0000-0002-6601-2165 + @@ -371196,7 +188202,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any muscle tissue of the distalmost portion of the digestive tract. - http://orcid.org/0000-0002-6601-2165 + @@ -371205,6 +188211,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -371237,7 +188244,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -371248,7 +188255,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -371280,7 +188287,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -371366,7 +188373,7 @@ The modern definition of neurosecretion has evolved to include the release of an A viscus that is part of a abdomen. - OBOL:automatic + OBOL:automatic @@ -371425,7 +188432,7 @@ The modern definition of neurosecretion has evolved to include the release of an A muscle layer that is part of the rectum. - http://orcid.org/0000-0002-6601-2165 + @@ -371455,7 +188462,7 @@ The modern definition of neurosecretion has evolved to include the release of an tunica muscularis recti - FMA:TA + FMA:TA @@ -371495,7 +188502,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any portion of smooth muscle tissue that is part of the rectum. - http://orcid.org/0000-0002-6601-2165 + @@ -371574,7 +188581,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx). - http://orcid.org/0000-0002-6601-2165 + @@ -371594,6 +188601,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -371601,8 +188609,8 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a lower lip. + FMA:24767 - SCTID:281630002 lower lip skin uberon UBERON:0018150 @@ -371612,7 +188620,7 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a lower lip. - OBOL:automatic + OBOL:automatic @@ -371638,6 +188646,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -371646,8 +188655,8 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a upper lip. + FMA:24765 - SCTID:281629007 upper lip skin uberon UBERON:0018151 @@ -371657,7 +188666,7 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of a upper lip. - OBOL:automatic + OBOL:automatic @@ -371702,7 +188711,7 @@ The modern definition of neurosecretion has evolved to include the release of an A stroma that is part of a pancreas. - OBOL:automatic + OBOL:automatic @@ -371760,6 +188769,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -371790,7 +188800,7 @@ The modern definition of neurosecretion has evolved to include the release of an - MA + MA @@ -371810,6 +188820,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -371825,7 +188836,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any portion of submucosa that lines the digestive tract. - http://orcid.org/0000-0002-6601-2165 + @@ -371844,6 +188855,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -371853,9 +188865,9 @@ The modern definition of neurosecretion has evolved to include the release of an Any organ component layer that consists of muscle tissue. NCITA class may refer to smooth muscle only + FMA:45634 NCIT:C75444 - UMLS:C0225358 uberon UBERON:0018260 layer of muscle tissue @@ -371864,7 +188876,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any organ component layer that consists of muscle tissue. - http://orcid.org/0000-0002-6601-2165 + @@ -371916,7 +188928,7 @@ The modern definition of neurosecretion has evolved to include the release of an A muscular coat that is part of a digestive tract. - OBOL:automatic + OBOL:automatic @@ -371945,7 +188957,7 @@ The modern definition of neurosecretion has evolved to include the release of an An bone foramen in the ethmoid bone. There are usually two Foramina ethmoidalia present on each side in the dog. Sometimes one is situated rostral to the other, but often it is dorsal. They are not homologous with the Foramen ethmoidale anterius and Foramen ethmoidale posterius of man. Therefore they are not listed separately.[NOMINA ANATOMICA VETERINARIA (2005)] - Wikipedia:Ethmoidal_foramina + ethmoidal foramen foramina ethmoidalia uberon @@ -371959,7 +188971,7 @@ The modern definition of neurosecretion has evolved to include the release of an An bone foramen in the ethmoid bone. - http://orcid.org/0000-0002-6601-2165 + @@ -371971,13 +188983,13 @@ The modern definition of neurosecretion has evolved to include the release of an ethmoid foramina - + ethmoidal foramina - + @@ -371997,6 +189009,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -372026,7 +189039,7 @@ The modern definition of neurosecretion has evolved to include the release of an The anatomical space within the intestine. - http://orcid.org/0000-0002-6601-2165 + @@ -372064,6 +189077,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -372095,7 +189109,7 @@ The modern definition of neurosecretion has evolved to include the release of an muscles innervated by the trigeminal nerve MFMO:0000072 - + @@ -372139,19 +189153,19 @@ The modern definition of neurosecretion has evolved to include the release of an ventricular cardiac muscle tissue - http://orcid.org/0000-0002-6601-2165 + ventricular heart muscle - http://orcid.org/0000-0002-6601-2165 + ventricular muscle - http://orcid.org/0000-0002-6601-2165 + @@ -372170,6 +189184,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -372428,9 +189443,9 @@ The modern definition of neurosecretion has evolved to include the release of an + BTO:0004638 FMA:13119 - SCTID:88410004 bronchial gland bronchial mucous gland peribronchial gland @@ -372490,7 +189505,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any region of epithelium that is part of a skin region. - http://orcid.org/0000-0002-6601-2165 + @@ -372526,7 +189541,7 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the eye that consists of both the retina and the optic choroid. - SCTID:110701000 + chorioretina choroid and retina retinachoroid @@ -372540,8 +189555,8 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the eye that consists of both the retina and the optic choroid. + UBERON:drseb - http://orcid.org/0000-0002-6601-2165 @@ -372680,20 +189695,20 @@ The modern definition of neurosecretion has evolved to include the release of an An exocrine gland that is part of a integumental system. - GOC:dos - http://orcid.org/0000-0002-6601-2165 + + GOC:dos integumental exocrine gland - http://orcid.org/0000-0002-6601-2165 + integumental system exocrine gland - http://orcid.org/0000-0002-6601-2165 + @@ -372712,6 +189727,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -372762,8 +189778,8 @@ The modern definition of neurosecretion has evolved to include the release of an + NCIT:C33596 - SCTID:282511007 uberon UBERON:0022292 splenic arteriole @@ -372806,7 +189822,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of organism substance that is secreted by a reproductive gland. - UBERON:cjm + UBERON:cjm @@ -372829,6 +189845,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -372916,7 +189933,7 @@ The modern definition of neurosecretion has evolved to include the release of an Serous membrane layer that is adjacent to and lines an organ. - http://orcid.org/0000-0002-6601-2165 + @@ -372972,7 +189989,7 @@ The modern definition of neurosecretion has evolved to include the release of an Serous membrane layer that lines to a body cavity. - http://orcid.org/0000-0002-6601-2165 + @@ -373018,7 +190035,7 @@ The modern definition of neurosecretion has evolved to include the release of an A specific region of the foregut into the area in which the lung will develop. - SCTID:34922002 + lung field uberon UBERON:0022361 @@ -373028,7 +190045,7 @@ The modern definition of neurosecretion has evolved to include the release of an A specific region of the foregut into the area in which the lung will develop. - GOC:dph + GOC:dph GOC:mtg_lung @@ -373038,6 +190055,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -373073,7 +190091,7 @@ The modern definition of neurosecretion has evolved to include the release of an embryonic neuroepithelium - http://orcid.org/0000-0002-6601-2165 + @@ -373098,7 +190116,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -373129,7 +190147,7 @@ The modern definition of neurosecretion has evolved to include the release of an - AEO + AEO @@ -373181,7 +190199,7 @@ The modern definition of neurosecretion has evolved to include the release of an MZH DHBA:12694 - + @@ -373229,7 +190247,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -373244,7 +190262,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -373276,46 +190293,44 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain. - uberon cranial nerve fiber bundle cranial nerve fiber tract cranial nerve or tract neuron projection bundle from brain UBERON:0034713 - cranial neuron projection bundle Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain. - ISBN:0471888893 - http://orcid.org/0000-0002-6601-2165 + + ISBN:0471888893 cranial nerve fiber bundle - http://orcid.org/0000-0002-6601-2165 + cranial nerve fiber tract - http://orcid.org/0000-0002-6601-2165 + cranial nerve or tract - http://orcid.org/0000-0002-6601-2165 + neuron projection bundle from brain - http://orcid.org/0000-0002-6601-2165 + @@ -373349,11 +190364,11 @@ The modern definition of neurosecretion has evolved to include the release of an The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa. + + EMAPA:37957 FMA:5866 MESH:D017776 - SCTID:276145003 - Wikipedia:Autonomic_nerve nervus visceralis visceral nerve uberon @@ -373364,13 +190379,13 @@ The modern definition of neurosecretion has evolved to include the release of an The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa. - Wikipedia:Autonomic_nerve + EMAPA:37957 - MA:th + MA:th @@ -373421,8 +190436,8 @@ The modern definition of neurosecretion has evolved to include the release of an + EMAPA:37958 - SCTID:181098007 uberon UBERON:0034729 @@ -373432,7 +190447,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37958 - MA:th + MA:th @@ -373451,7 +190466,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -373489,7 +190504,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any substance in the body or expelled from the body that is in a gaseous state. - http://orcid.org/0000-0002-6601-2165 + @@ -373543,7 +190558,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any portion of gas located in a part of the respiratory system that is composed primarily of air. - http://orcid.org/0000-0002-6601-2165 + @@ -373572,6 +190587,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -373595,7 +190611,7 @@ The modern definition of neurosecretion has evolved to include the release of an The area of axial mesoderm that develops into the prechordal plate. - MGI:anna + MGI:anna @@ -373623,8 +190639,8 @@ The modern definition of neurosecretion has evolved to include the release of an Endocardium that is part of the left atrium. Endocardium of atrium which is continuous with the tunica intima of the trunk of pulmonary vein. + FMA:7286 - SCTID:190064008 VHOG:0001226 endocardium of left atrium left atrial endocardium @@ -373637,7 +190653,7 @@ The modern definition of neurosecretion has evolved to include the release of an Endocardium that is part of the left atrium. - http://orcid.org/0000-0002-6601-2165 + @@ -373706,14 +190722,10 @@ The modern definition of neurosecretion has evolved to include the release of an An multicellular anatomical structure that has subparts of multiple organs as a part. - - - CARO:0020001 uberon anatomical cluster UBERON:0034921 - multi organ part structure @@ -373748,14 +190760,10 @@ The modern definition of neurosecretion has evolved to include the release of an A cluster of cells, largely surrounded by a morphological boundary. - - - CARO:0020002 FMA:62807 uberon UBERON:0034922 - cell cluster @@ -373773,55 +190781,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - 2 - - - - Material anatomical entity consisting of multiple anatomical structures that are not connected to each other. - - - - CARO:0020000 - FBbt:00007276 - uberon - UBERON:0034923 - - disconnected anatomical group - - - - - - CARO - - - - - Material anatomical entity consisting of multiple anatomical structures that are not connected to each other. - CARO:0020000 - - - - @@ -373834,19 +190793,15 @@ The modern definition of neurosecretion has evolved to include the release of an A collection of anatomical structures that are alike in terms of their morphology or developmental origin. resolve if this should be a subclass of disconnected anatomical group. Some collections (e.g. the skeleton or skull) are arguably connected - - - uberon UBERON:0034925 - anatomical collection A collection of anatomical structures that are alike in terms of their morphology or developmental origin. - http://orcid.org/0000-0002-6601-2165 + @@ -373854,7 +190809,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -373895,7 +190850,7 @@ The modern definition of neurosecretion has evolved to include the release of an A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures. - http://orcid.org/0000-0002-6601-2165 + @@ -373934,15 +190889,15 @@ The modern definition of neurosecretion has evolved to include the release of an The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts. + BTO:0001513 MGI:cs - http://orcid.org/0000-0002-6601-2165 biliary system epithelium - http://orcid.org/0000-0002-6601-2165 + @@ -373954,7 +190909,7 @@ The modern definition of neurosecretion has evolved to include the release of an biliary tract epithelium - http://orcid.org/0000-0002-6601-2165 + @@ -373989,7 +190944,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any organ component layer that consists of smooth muscle tissue. - http://orcid.org/0000-0002-6601-2165 + @@ -374059,7 +191014,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any gaseous product of an excretory process. - http://orcid.org/0000-0002-6601-2165 + @@ -374099,7 +191054,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any excreted gas that is produced by the digestive tract. - http://orcid.org/0000-0002-6601-2165 + @@ -374111,7 +191066,7 @@ The modern definition of neurosecretion has evolved to include the release of an flatus - Wikipedia:Flatulence + @@ -374149,7 +191104,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any portion of gas located in a part of the respiratory system. - http://orcid.org/0000-0002-6601-2165 + @@ -374181,8 +191136,8 @@ The modern definition of neurosecretion has evolved to include the release of an + NCIT:C25787 - UMLS:C1512086 uberon duct epithelium ductal epithelium @@ -374206,7 +191161,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + + @@ -374224,7 +191180,7 @@ The modern definition of neurosecretion has evolved to include the release of an Mesenchyme that is part of a developing jaw [Automatically generated definition]. - OBOL:automatic + OBOL:automatic @@ -374286,7 +191242,7 @@ The modern definition of neurosecretion has evolved to include the release of an - SCTID:277967008 + hemorrhoidal artery uberon UBERON:0035039 @@ -374336,7 +191292,7 @@ The modern definition of neurosecretion has evolved to include the release of an A post-anal tail that attaches outside the tail. - http://orcid.org/0000-0002-6601-2165 + @@ -374374,13 +191330,13 @@ The modern definition of neurosecretion has evolved to include the release of an Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included. - https://github.com/EnvironmentOntology/envo/issues/110 + digestive tract contents - + @@ -374407,10 +191363,10 @@ The modern definition of neurosecretion has evolved to include the release of an Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface. + + FMA:61695 NCIT:C29667 - SCTID:261060002 - UMLS:C0489451 surface of body uberon UBERON:0035159 @@ -374439,29 +191395,30 @@ The modern definition of neurosecretion has evolved to include the release of an - + - + + - + - + + + FMA:70505 NCIT:C32552 - SCTID:244216003 - UMLS:C0447038 external carotid arterial subdivision subdivision of external carotid artery uberon @@ -374525,10 +191482,10 @@ The modern definition of neurosecretion has evolved to include the release of an Any of several arteries that arise from the aorta and supply blood to the esophagus. + + FMA:4149 NCIT:C32535 - SCTID:56548006 - UMLS:C0226294 aortic esophageal artery oesophageal artery uberon @@ -374540,7 +191497,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -374551,7 +191508,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -374601,8 +191558,8 @@ The modern definition of neurosecretion has evolved to include the release of an + FMA:51797 - SCTID:149683007 ciliary vein uberon UBERON:0035546 @@ -374644,11 +191601,10 @@ The modern definition of neurosecretion has evolved to include the release of an - SCTID:77852007 + uberon UBERON:0035548 colic artery - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb @@ -374699,7 +191655,7 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin. - http://orcid.org/0000-0002-6601-2165 + @@ -374732,11 +191688,11 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers. + + + FMA:76719 NCIT:C33666 - SCTID:341382008 - UMLS:C0226513 - Wikipedia:Superficial_vein uberon superfical vein superficial veins @@ -374754,19 +191710,19 @@ The modern definition of neurosecretion has evolved to include the release of an superfical vein - Wikipedia:Superficial_vein + superficial veins - Wikipedia:Superficial_vein + superficial vessels - Wikipedia:Superficial_vein + @@ -374802,7 +191758,7 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin. - http://orcid.org/0000-0002-6601-2165 + @@ -374829,11 +191785,11 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery. + + + FMA:76718 NCIT:C32444 - SCTID:341484008 - UMLS:C0226514 - Wikipedia:Deep_vein uberon deep veins deep vessels @@ -374850,13 +191806,13 @@ The modern definition of neurosecretion has evolved to include the release of an deep veins - Wikipedia:Deep_vein + deep vessels - Wikipedia:Deep_vein + @@ -374884,8 +191840,8 @@ The modern definition of neurosecretion has evolved to include the release of an Any chamber of the left side of the heart. + FMA:7166 - SCTID:362008007 uberon UBERON:0035553 left cardiac chamber @@ -374894,7 +191850,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any chamber of the left side of the heart. - http://orcid.org/0000-0002-6601-2165 + @@ -374922,8 +191878,8 @@ The modern definition of neurosecretion has evolved to include the release of an Any chamber of the right side of the heart. + FMA:7165 - SCTID:362007002 uberon UBERON:0035554 right cardiac chamber @@ -374932,7 +191888,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any chamber of the right side of the heart. - http://orcid.org/0000-0002-6601-2165 + @@ -374940,7 +191896,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -374948,11 +191904,11 @@ The modern definition of neurosecretion has evolved to include the release of an The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. + + + FMA:76554 NCIT:C32574 - SCTID:120612006 - UMLS:C0229243 - Wikipedia:Accessory_visual_structures adnexa oculi uberon accessory parts of orbital region @@ -374971,24 +191927,29 @@ The modern definition of neurosecretion has evolved to include the release of an The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. + + HPO:pr - UBERON:cjm - http://medical-dictionary.thefreedictionary.com/ocular+adnexa - https://github.com/obophenotype/uberon/issues/1132 + UBERON:cjm adnexa oculi - http://medical-dictionary.thefreedictionary.com/ocular+adnexa + + + + + accessory visual structures + + accessory visual structures FMA:76554 - Wikipedia:Accessory_visual_structures @@ -375000,14 +191961,14 @@ The modern definition of neurosecretion has evolved to include the release of an appendage of eye - http://medical-dictionary.thefreedictionary.com/ocular+adnexa + appendages of the eye - http://medical-dictionary.thefreedictionary.com/ocular+adnexa - + + @@ -375019,7 +191980,7 @@ The modern definition of neurosecretion has evolved to include the release of an structurae oculi accessoriae - Wikipedia:Accessory_visual_structures + @@ -375039,6 +192000,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -375076,7 +192038,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -375099,9 +192061,43 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + FMA:223208 + NCIT:C12930 + uberon + UBERON:0035767 + + intrapulmonary bronchus + + + + + @@ -375180,7 +192176,7 @@ The modern definition of neurosecretion has evolved to include the release of an A muscle layer that is part of the sigmoid colon. - https://github.com/obophenotype/uberon/issues/1162 + @@ -375218,8 +192214,8 @@ The modern definition of neurosecretion has evolved to include the release of an + FMA:12241 - SCTID:304404008 uberon UBERON:0035809 serous cavity @@ -375249,7 +192245,7 @@ The modern definition of neurosecretion has evolved to include the release of an The sum of epicardial and paracardial fat deposits. - SCTID:42267001 + ZFA:0005765 uberon UBERON:0035814 @@ -375259,7 +192255,7 @@ The modern definition of neurosecretion has evolved to include the release of an The sum of epicardial and paracardial fat deposits. - DOI:10.5935/abc.20130138 + @@ -375305,13 +192301,13 @@ The modern definition of neurosecretion has evolved to include the release of an Fat deposits in the mediastinum outside the parietal pericardium . - DOI:10.5935/abc.20130138 + intrathoracic fat - DOI:10.5935/abc.20130138 + @@ -375346,7 +192342,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any fat deposit surrounding a visceral organ. - UBERON:cjm + UBERON:cjm @@ -375370,6 +192366,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -375389,8 +192386,8 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity. + FMA:12267 - Wikipedia:Abdominopelvic_cavity cavitas abdominis et pelvis uberon UBERON:0035819 @@ -375400,13 +192397,13 @@ The modern definition of neurosecretion has evolved to include the release of an The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity. - UBERON:cjm + UBERON:cjm cavitas abdominis et pelvis - FMA:TA + FMA:TA @@ -375438,6 +192435,7 @@ The modern definition of neurosecretion has evolved to include the release of an A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity. EMAPA:16137 FMA:9908 + MA:0000054 uberon peritoneal component UBERON:0035820 @@ -375447,7 +192445,7 @@ The modern definition of neurosecretion has evolved to include the release of an A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity. - https://github.com/obophenotype/uberon/issues/86 + @@ -375462,7 +192460,14 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + @@ -375482,8 +192487,8 @@ The modern definition of neurosecretion has evolved to include the release of an The domain of the diaphragm that is a thin domed sheet of muscle composed of a radial array of myofibers extending laterally from the ribs and medially to a central tendon. + FMA:58277 - SCTID:368048007 costal part of diaphragm pars costalis diaphragmatis uberon @@ -375499,7 +192504,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:23586979 + @@ -375510,13 +192515,13 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:23586979 + The domain of the diaphragm that is a thin domed sheet of muscle composed of a radial array of myofibers extending laterally from the ribs and medially to a central tendon. - PMID:23586979 + @@ -375528,7 +192533,7 @@ The modern definition of neurosecretion has evolved to include the release of an pars costalis diaphragmatis - FMA:TA + FMA:TA @@ -375575,7 +192580,7 @@ The modern definition of neurosecretion has evolved to include the release of an EMAPA:37987 - MA:th + MA:th @@ -375637,7 +192642,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -375685,7 +192690,7 @@ The modern definition of neurosecretion has evolved to include the release of an - EHDAA2 + EHDAA2 @@ -375724,8 +192729,8 @@ The modern definition of neurosecretion has evolved to include the release of an An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles. - http://www.nature.com/nature/journal/v520/n7548/full/nature14435.html#bx1 - https://orcid.org/0000-0003-3308-6245 + + @@ -375798,8 +192803,8 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical junction that is between the sigmoid colon and rectum. + NCIT:C54188 - SCTID:245429006 uberon rectosigmoid region UBERON:0036214 @@ -375809,9 +192814,9 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical junction that is between the sigmoid colon and rectum. + + NCIT:C54188 - https://github.com/obophenotype/uberon/issues/1319 - https://www.cdc.gov/cancer/npcr/pdf/abstracting/colon.pdf @@ -375839,21 +192844,18 @@ The modern definition of neurosecretion has evolved to include the release of an Material anatomical entity that forms the outermost boundary of an anatomical structure. - - - AAO:0010270 + AEO:0000154 ZFA:0005594 uberon UBERON:0036215 - anatomical surface region Material anatomical entity that forms the outermost boundary of an anatomical structure. - https://github.com/obophenotype/uberon/issues/1324 + @@ -375890,8 +192892,8 @@ The modern definition of neurosecretion has evolved to include the release of an A bodily fluid that is located in the coelom. - PMID:10874572 - https://github.com/obophenotype/uberon/issues/1326 + + @@ -375926,7 +192928,7 @@ The modern definition of neurosecretion has evolved to include the release of an Any gland that is part os the respiratory system. - UBERON:cjm + UBERON:cjm @@ -375983,7 +192985,7 @@ The modern definition of neurosecretion has evolved to include the release of an A notochord that has persisted beyond the embryonic stage. - UBERON:cjm + UBERON:cjm @@ -376098,9 +193100,9 @@ The modern definition of neurosecretion has evolved to include the release of an The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit. + + FMA:52972 - SCTID:280243001 - Wikipedia:Zygomaticotemporal_nerve ramus zygomaticotemporalis (Nervus zygomaticus) ramus zygomaticotemporalis nervus zygomatici zygomaticotemporal branch of zygomatic nerve @@ -376114,7 +193116,7 @@ The modern definition of neurosecretion has evolved to include the release of an The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit. - Wikipedia:Zygomaticotemporal_nerve + @@ -376126,7 +193128,7 @@ The modern definition of neurosecretion has evolved to include the release of an ramus zygomaticotemporalis nervus zygomatici - FMA:TA + FMA:TA @@ -376139,13 +193141,13 @@ The modern definition of neurosecretion has evolved to include the release of an zygomaticotemporal - Wikipedia:Zygomaticotemporal_nerve + zygomaticotemporal branch - Wikipedia:Zygomaticotemporal_nerve + @@ -376177,7 +193179,7 @@ The modern definition of neurosecretion has evolved to include the release of an - SCTID:13152008 + uberon UBERON:0036268 pelvic vein @@ -376217,7 +193219,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376228,7 +193230,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376277,7 +193279,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376288,7 +193290,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376346,7 +193348,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376477,13 +193479,13 @@ The modern definition of neurosecretion has evolved to include the release of an A mucosa that is part of a lip region [Automatically generated definition]. - OBOL:automatic + OBOL:automatic labial mucosa - UBERON:cjm + UBERON:cjm @@ -376502,6 +193504,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -376510,8 +193513,8 @@ The modern definition of neurosecretion has evolved to include the release of an + FMA:225251 - SCTID:297287005 uberon UBERON:0036301 vasculature of spleen @@ -376520,7 +193523,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376558,6 +193561,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -376606,7 +193610,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376617,7 +193621,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376659,7 +193663,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376670,7 +193674,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376712,7 +193716,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376723,7 +193727,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376777,7 +193781,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376788,7 +193792,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376799,7 +193803,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376825,23 +193829,26 @@ The modern definition of neurosecretion has evolved to include the release of an + + FMA:18211 pulmonary arterial wall uberon UBERON:0036422 + wall of pulmonary artery - FMA + FMA @@ -376852,7 +193859,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376894,7 +193901,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376905,7 +193912,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376942,7 +193949,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376953,7 +193960,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -376997,7 +194004,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -377008,7 +194015,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -377034,6 +194041,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -377050,7 +194058,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -377061,7 +194069,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -377123,7 +194131,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -377134,7 +194142,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -377145,7 +194153,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -377156,7 +194164,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -377207,8 +194215,6 @@ The modern definition of neurosecretion has evolved to include the release of an uberon UBERON:0039222 cystic artery - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb - https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb @@ -377219,15 +194225,15 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA - Wikipedia + FMA + Wikipedia An artery that supplies oxygenated blood to the cystic duct. - http://orcid.org/0000-0002-6601-2165 - https://en.wikipedia.org/wiki/Cystic_artery + + @@ -377285,7 +194291,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -377304,11 +194310,11 @@ The modern definition of neurosecretion has evolved to include the release of an - + - + @@ -377319,7 +194325,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -377368,7 +194374,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -377379,7 +194385,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -377421,7 +194427,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -377458,10 +194464,11 @@ The modern definition of neurosecretion has evolved to include the release of an 2012-02-05T05:23:01Z + + EMAPA:36657 FMA:24758 NCIT:C33561 - SCTID:361703006 UMLS:C0222084 face skin uberon @@ -377475,8 +194482,8 @@ The modern definition of neurosecretion has evolved to include the release of an A zone of skin that is part of the face. + UBERON:EJS - https://github.com/obophenotype/uberon/issues/34 @@ -377527,7 +194534,7 @@ The modern definition of neurosecretion has evolved to include the release of an A parenchyma that is part of a spleen. - OBOL:automatic + OBOL:automatic @@ -377570,7 +194577,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical junction between two parts of the digestive tract. - https://orcid.org/0000-0002-7073-9172 + @@ -377589,7 +194596,7 @@ The modern definition of neurosecretion has evolved to include the release of an This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon - http://purl.obolibrary.org/obo/tao.owl + @@ -377626,13 +194633,13 @@ The modern definition of neurosecretion has evolved to include the release of an Cartilage which is part of the axial skeleton. - ZFIN:curator + ZFIN:curator This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon - http://purl.obolibrary.org/obo/tao.owl + @@ -377646,11 +194653,12 @@ The modern definition of neurosecretion has evolved to include the release of an the ZFA class from which this was derived is not explicitly classified as a capillary - need to verify for taxon histology differences Blood vessel endothelium that has pores that allow passage small molecules and proteins[ZFA]. fenestrated blood vessel endothelium + + FMA:63196 NCIT:C32595 TAO:0005260 UMLS:C1179615 - Wikipedia:Capillary#Types ZFA:0005260 fenestrated capillary vessel uberon @@ -377661,20 +194669,20 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA - ZFA + ZFA Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse. - Wikipedia:Capillary#Types - Wikipedia:Fenestra_(histology) + + @@ -377712,13 +194720,13 @@ The modern definition of neurosecretion has evolved to include the release of an Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes. - ZFIN:curator + ZFIN:curator This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon - http://purl.obolibrary.org/obo/tao.owl + @@ -377761,7 +194769,7 @@ The modern definition of neurosecretion has evolved to include the release of an This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon - http://purl.obolibrary.org/obo/aao.owl + @@ -377803,7 +194811,7 @@ The modern definition of neurosecretion has evolved to include the release of an This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon - http://purl.obolibrary.org/obo/aao.owl + @@ -377845,7 +194853,7 @@ The modern definition of neurosecretion has evolved to include the release of an This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon - http://purl.obolibrary.org/obo/aao.owl + @@ -377864,6 +194872,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -377887,7 +194896,7 @@ The modern definition of neurosecretion has evolved to include the release of an This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon - http://purl.obolibrary.org/obo/aao.owl + @@ -377940,7 +194949,7 @@ The modern definition of neurosecretion has evolved to include the release of an This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon - http://purl.obolibrary.org/obo/aao.owl + @@ -377976,7 +194985,7 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical surface that is part of a bone. - PHENOSCAPE + PHENOSCAPE @@ -378249,7 +195258,7 @@ The modern definition of neurosecretion has evolved to include the release of an Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. - https://microbiomedb.org/ + @@ -378286,80 +195295,7 @@ The modern definition of neurosecretion has evolved to include the release of an Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. - https://microbiomedb.org/ - - - - - - - - - - - - - - - - - - - - - - A collection of Purkinje fibers that receives signals from the right and left bundle branches and innervates the ventricular cardiac muscle. The Purkinje fiber network creates synchronized contractions of the heart ventricles. - - Purkinje fibre network - uberon - UBERON:8000009 - Purkinje fiber network - - - - - - https://github.com/obophenotype/uberon/issues/1785 - https://orcid.org/0000-0001-5208-3432 - https://orcid.org/0000-0002-9791-0064 - - - - - - - - - - - https://github.com/obophenotype/uberon/issues/1785 - https://orcid.org/0000-0001-5208-3432 - https://orcid.org/0000-0002-9791-0064 - - - - - - - - - - - https://github.com/obophenotype/uberon/issues/1785 - https://orcid.org/0000-0001-5208-3432 - https://orcid.org/0000-0002-9791-0064 - - - - - A collection of Purkinje fibers that receives signals from the right and left bundle branches and innervates the ventricular cardiac muscle. The Purkinje fiber network creates synchronized contractions of the heart ventricles. - PMID:26786210 - - - - - Purkinje fibre network - PMID:26786210 + @@ -378398,8 +195334,8 @@ The modern definition of neurosecretion has evolved to include the release of an Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact. - https://medical-dictionary.thefreedictionary.com/serosa+of+liver - https://orcid.org/0000-0002-0449-2730 + + @@ -378412,7 +195348,7 @@ The modern definition of neurosecretion has evolved to include the release of an tunica serosa hepatis LATIN - https://medical-dictionary.thefreedictionary.com/serosa+of+liver + @@ -378454,9 +195390,9 @@ The modern definition of neurosecretion has evolved to include the release of an Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson. + + FMA:15812 - https://medical-dictionary.thefreedictionary.com/subserosa+of+liver - https://orcid.org/0000-0002-0449-2730 @@ -378468,7 +195404,7 @@ The modern definition of neurosecretion has evolved to include the release of an tela subserosa hepatis - https://medical-dictionary.thefreedictionary.com/subserosa+of+liver + @@ -378506,7 +195442,7 @@ The modern definition of neurosecretion has evolved to include the release of an Venule of villus of small intestine. - https://orcid.org/0000-0003-4183-8865 + @@ -378546,7 +195482,7 @@ The modern definition of neurosecretion has evolved to include the release of an Arteriole of villus of small intestine. - http://orcid.org/0000-0003-4183-8865 + @@ -378583,7 +195519,7 @@ The modern definition of neurosecretion has evolved to include the release of an A venule that is located in the anorectum. - http://orcid.org/0000-0003-3440-1876 + @@ -378620,7 +195556,7 @@ The modern definition of neurosecretion has evolved to include the release of an An arteriole that is located in the anorectum. - http://orcid.org/0000-0003-3440-1876 + @@ -378656,8 +195592,8 @@ The modern definition of neurosecretion has evolved to include the release of an An arteriole located in the colon. - http://orcid.org/0000-0003-3440-1876 - http://orcid.org/0000-0003-4183-8865 + + @@ -378680,6 +195616,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -378704,7 +195641,50 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical junction between two parts of the intestine. - https://orcid.org/0000-0002-7073-9172 + + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosal gland located in a bronchus. + + + airway submucosal gland + bronchial submucosal gland + submucosal bronchial gland + submucosal bronchus gland + uberon + UBERON:8410043 + + bronchus submucosal gland + + + + + A submucosal gland located in a bronchus. + + @@ -378740,8 +195720,8 @@ The modern definition of neurosecretion has evolved to include the release of an A venule located in the colon. - https://orcid.org/0000-0003-3440-1876 - https://orcid.org/0000-0003-4183-8865 + + @@ -378807,11 +195787,11 @@ The modern definition of neurosecretion has evolved to include the release of an A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus. - DOI:10.1007/978-3-319-26938-2_8 - DOI:10.1148/rg.2015150037 - PMID:29742860 - http://orcid.org/0000-0002-6826-8770 - http://orcid.org/0000-0003-3440-1876 + + + + + @@ -378848,7 +195828,7 @@ The modern definition of neurosecretion has evolved to include the release of an A capillary that is part of the anorectum. - http://orcid.org/0000-0003-3440-1876 + @@ -378885,7 +195865,7 @@ The modern definition of neurosecretion has evolved to include the release of an A capillary that is part of the colon. - http://orcid.org/0000-0003-3440-1876 + @@ -378925,7 +195905,7 @@ The modern definition of neurosecretion has evolved to include the release of an A capillary that is part of a small intestine. - http://orcid.org/0000-0003-3440-1876 + @@ -378954,7 +195934,7 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosal gland found in a respiratory tract. - + 2022-03-24T14:21:59Z EFO:0010666 respiratory tract submucosal gland @@ -378967,8 +195947,8 @@ The modern definition of neurosecretion has evolved to include the release of an A submucosal gland found in a respiratory tract. - http://orcid.org/0000-0003-3440-1876 - http://orcid.org/0000-0003-4183-8865 + + @@ -378992,8 +195972,8 @@ The modern definition of neurosecretion has evolved to include the release of an Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins. - Wikipedia:Microcirculation - http://orcid.org/0000-0002-7073-9172 + + @@ -379044,13 +196024,10 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical system that eliminates waste products that arise as a result of metabolic activity. - http://orcid.org/0000-0002-6095-8718 2022-05-25T18:21:29Z - BTO:0006338 uberon UBERON:8450002 - excretory system @@ -379059,12 +196036,6 @@ The modern definition of neurosecretion has evolved to include the release of an An anatomical system that eliminates waste products that arise as a result of metabolic activity. GO:0007588 - - - - BTO:0006338 - https://orcid.org/0000-0003-4423-4370 - @@ -379091,7 +196062,7 @@ The modern definition of neurosecretion has evolved to include the release of an A capillary that is part of the brain. - + 2022-06-24T09:28:31Z uberon UBERON:8480001 @@ -379101,7 +196072,7 @@ The modern definition of neurosecretion has evolved to include the release of an A capillary that is part of the brain. - https://orcid.org/0000-0002-0819-0473 + @@ -379128,7 +196099,7 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of the thoracic aorta. - + 2022-06-24T09:30:54Z uberon UBERON:8480002 @@ -379138,592 +196109,61 @@ The modern definition of neurosecretion has evolved to include the release of an A portion of smooth muscle tissue that is part of the thoracic aorta. - https://orcid.org/0000-0002-0819-0473 - - - - - - - - - - - - - - - - - - - - - - - - - - A zone of skin that is above the clavicle zone in the pectoral girdle region. - - 2022-08-29T14:17:12Z - uberon - UBERON:8480025 - skin of clavicle region - - - - - A zone of skin that is above the clavicle zone in the pectoral girdle region. - https://orcid.org/0000-0002-0819-0473 - - - - - - - - - - - - - - - - - - - - - - - - - - - A zone of skin that is above the iliac crest in the pelvic girdle bone/zone. - - 2022-08-29T14:19:16Z - skin of posterior iliac crest region - uberon - UBERON:8480026 - skin of iliac crest region - - - - - A zone of skin that is above the iliac crest in the pelvic girdle bone/zone. - https://orcid.org/0000-0002-0819-0473 - - - - - - - - - - - - - - - - - - - - - - - - - - - A zone of skin that is part of the external genitalia. - - 2022-08-30T06:55:06Z - uberon - UBERON:8480029 - skin of external genitalia - - - - - A zone of skin that is part of the external genitalia. - https://orcid.org/0000-0002-0819-0473 - - - - - - - - - - - - - - - - - - - - - - - - - - - A zone of skin part of some gonad. - - 2023-08-29T10:24:24Z - uberon - UBERON:8480074 - skin of gonad - - - - - A zone of skin part of some gonad. - https://orcid.org/0000-0002-0819-0473 - - - - - - - - - - - - - - - A muscle tissue that is associated with soft internal organs (viscera). - - 2023-02-16T10:17:46Z - visceral muscle - uberon - UBERON:8600004 - It is quite common to refer to visceral muscles as smooth muscles, by analogy with vertebrates; however, most visceral muscles in arthropods are actually striated. - visceral muscle tissue - - - - - A muscle tissue that is associated with soft internal organs (viscera). - BTO:0002780 - CLAO:0001295 - - - - - visceral muscle - BTO:0002780 - - - - - It is quite common to refer to visceral muscles as smooth muscles, by analogy with vertebrates; however, most visceral muscles in arthropods are actually striated. - FBbt:00005070 - https://en.wikipedia.org/wiki/Smooth_muscle - PMID:8720463 - - - - - - - - - - A striated muscle tissue that is associated with soft internal organs (viscera). - - 2023-02-16T10:34:43Z - striated visceral muscle tissue - uberon - UBERON:8600006 - visceral striated muscle tissue - - - - - A striated muscle tissue that is associated with soft internal organs (viscera). - PMID:8720463 - https://pressbooks.pub/rbtallitsch/chapter/chapter-6-muscle-tissue/ - - - - - - - - - - - - - - - - - - - - - - - - - - A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium. - - - 2023-05-02T08:57:27Z - uberon - UBERON:8600012 - - submucosal gland acinus - - - - - A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium. - PMID:17394068 - PMID:17707699 - PMID:25648514 - PMID:30864819 + - + - - - - - - - - - + + - - + + - A discrete anatomical unit of the lung that is composed of a segmental bronchus and the lung tissue supplied by that bronchus. A bronchopulmonary segment exhibits a pyramidal shape, with its apex pointing towards the center of the lung and its base toward the pleural surface. - - - - 2023-07-20T12:43:29Z - lung segment - uberon - UBERON:8600017 - - A bronchopulmonary segment is surrounded by connective tissue septa, which are continuous with the pleural surface and prevent air collateralization between segments somewhat. In humans, the right lung has ten bronchopulmonary segments and eight or nine bronchopulmonary segments in the left lung. - bronchopulmonary segment + A protein coding gene SHH in human. + gene + HGNC:10848 + Category=external. + SHH (human) - + - A discrete anatomical unit of the lung that is composed of a segmental bronchus and the lung tissue supplied by that bronchus. A bronchopulmonary segment exhibits a pyramidal shape, with its apex pointing towards the center of the lung and its base toward the pleural surface. - FMA:7312 - PMID:18271171 - PMID:33620799 - doi:10.1016/j.mpaic.2008.09.022 - - - - - lung segment - PMID:33620799 - - - - - A bronchopulmonary segment is surrounded by connective tissue septa, which are continuous with the pleural surface and prevent air collateralization between segments somewhat. In humans, the right lung has ten bronchopulmonary segments and eight or nine bronchopulmonary segments in the left lung. - PMID:18271171 - doi:10.1016/j.mpaic.2008.09.022 + A protein coding gene SHH in human. + PRO:DNx - + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + - - + + - A venule that is part of a lung and drains oxygenated blood from pulmonary capillaries. A pulmonary venule merges into a pulmonary vein branch that runs in the pulmonary interlobular septa. - - 2023-10-24T11:26:27Z - uberon - UBERON:8600024 - pulmonary venule + A protein coding gene FGF8 in human. + gene + HGNC:3686 + Category=external. + FGF8 (human) - + - A venule that is part of a lung and drains oxygenated blood from pulmonary capillaries. A pulmonary venule merges into a pulmonary vein branch that runs in the pulmonary interlobular septa. - PMID:22283705 - PMID:30247823 + A protein coding gene FGF8 in human. + PRO:DNx - - - - - - - - - example to be eventually removed - example to be eventually removed - - - - - - - - failed exploratory term - The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job - Person:Alan Ruttenberg - failed exploratory term - - - - - - - - metadata complete - Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete. - metadata complete - - - - - - - - organizational term - Term created to ease viewing/sort terms for development purpose, and will not be included in a release - organizational term - - - - - - - - ready for release - Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release." - ready for release - - - - - - - - metadata incomplete - Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors. - metadata incomplete - - - - - - - - uncurated - Nothing done yet beyond assigning a unique class ID and proposing a preferred term. - uncurated - - - - - - - - pending final vetting - All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor. - pending final vetting - - - - - - - - placeholder removed - placeholder removed - - - - - - - - terms merged - An editor note should explain what were the merged terms and the reason for the merge. - terms merged - - - - - - - - term imported - This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use. - term imported - - - - - - - - term split - This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created. - term split - - - - - - - - universal - Hard to give a definition for. Intuitively a "natural kind" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents. - Alan Ruttenberg - A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf - universal - - - - - - - - defined class - A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal - "definitions", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal. - Alan Ruttenberg - defined class - - - - - - - - named class expression - A named class expression is a logical expression that is given a name. The name can be used in place of the expression. - named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions - Alan Ruttenberg - named class expression - - - - - - - - to be replaced with external ontology term - Terms with this status should eventually replaced with a term from another ontology. - Alan Ruttenberg - group:OBI - to be replaced with external ontology term - - - - - - - - requires discussion - A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues. - Alan Ruttenberg - group:OBI - requires discussion - - - - - - - - The term was added to the ontology on the assumption it was in scope, but it turned out later that it was not. - This obsolesence reason should be used conservatively. Typical valid examples are: un-necessary grouping classes in disease ontologies, a phenotype term added on the assumption it was a disease. - - https://github.com/information-artifact-ontology/ontology-metadata/issues/77 - https://orcid.org/0000-0001-5208-3432 - out of scope - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 2 - - - - - - - - - - - - - - - - - - - - - 1 - - - - - - - - - - - - - - - - - - - - - 2 - - - - - - - - - - - - - - - - - - - - - 2 - - - - - - @@ -380124,93 +196436,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - @@ -380236,7 +196461,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:16417468 + @@ -380313,21 +196538,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - @@ -380368,7 +196578,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -380395,7 +196605,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -380602,7 +196812,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA-abduced-lr + FMA-abduced-lr @@ -380629,7 +196839,7 @@ The modern definition of neurosecretion has evolved to include the release of an - definitional + definitional @@ -380656,7 +196866,7 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/The-neural-crest + @@ -380785,7 +196995,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia:Vitelline_vein + @@ -380842,7 +197052,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -380884,7 +197094,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia:Vitelline_vein + @@ -380912,7 +197122,7 @@ The modern definition of neurosecretion has evolved to include the release of an may be present in other parts in other species - FMA + FMA @@ -381027,7 +197237,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381054,7 +197264,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia:Vitelline_vein + @@ -381081,7 +197291,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Wikipedia + Wikipedia @@ -381108,7 +197318,7 @@ The modern definition of neurosecretion has evolved to include the release of an - PMID:22179203 + @@ -381135,7 +197345,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381162,7 +197372,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381189,7 +197399,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381216,7 +197426,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381243,7 +197453,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381270,7 +197480,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381297,7 +197507,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381324,7 +197534,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381351,7 +197561,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381378,7 +197588,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381405,7 +197615,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381492,7 +197702,7 @@ The modern definition of neurosecretion has evolved to include the release of an - https://github.com/obophenotype/uberon/wiki/The-neural-crest + @@ -381519,7 +197729,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381546,7 +197756,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381573,7 +197783,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381590,7 +197800,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381617,7 +197827,7 @@ The modern definition of neurosecretion has evolved to include the release of an - cjm + cjm @@ -381649,61 +197859,7 @@ The modern definition of neurosecretion has evolved to include the release of an - ZFA - - - - - - - - - - - - - - - - - - - - - - - - - - - PMID:16417468 - - - - - - - - - - - - - - - - - - - - - - - - - - - PMID:16417468 + ZFA @@ -381730,8 +197886,8 @@ The modern definition of neurosecretion has evolved to include the release of an - AAO - https://github.com/geneontology/go-ontology/issues/16143 + + AAO @@ -381748,21 +197904,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - @@ -381944,7 +198085,7 @@ The modern definition of neurosecretion has evolved to include the release of an - FMA + FMA @@ -381994,36 +198135,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - @@ -382525,15 +198636,15 @@ The modern definition of neurosecretion has evolved to include the release of an - - - + + + @@ -382546,25 +198657,16 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - + - + - + @@ -382672,9 +198774,10 @@ The modern definition of neurosecretion has evolved to include the release of an - - - + + + + @@ -382682,10 +198785,9 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - + + + @@ -382715,9 +198817,10 @@ The modern definition of neurosecretion has evolved to include the release of an - - - + + + + @@ -382725,10 +198828,9 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - + + + @@ -382758,9 +198860,10 @@ The modern definition of neurosecretion has evolved to include the release of an - - - + + + + @@ -382768,10 +198871,9 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - + + + @@ -383061,9 +199163,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - - - + + + @@ -383072,9 +199174,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - - - + + + @@ -383106,9 +199208,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - - - + + + @@ -383117,9 +199219,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - - - + + + @@ -383151,9 +199253,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - - - + + + @@ -383162,9 +199264,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - - - + + + @@ -383187,6 +199289,51 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase + + This rule is dubious: added as a quick fix for expected inference in GO-CAM. The problem is most acute for transmembrane proteins, such as receptors or cell adhesion molecules, which have some subfunctions inside the cell (e.g. kinase activity) and some subfunctions outside (e.g. ligand binding). Correct annotation of where these functions occurs leads to incorrect inference about the location of the whole protein. This should probably be weakened to "... -> overlaps" + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + If a molecular function (X) has a regulatory subfunction, then any gene product which is an input to that subfunction has an activity that directly_regulates X. Note: this is intended for cases where the regaultory subfunction is protein binding, so it could be tightened with an additional clause to specify this. inferring direct reg edge from input to regulatory subfunction @@ -383371,9 +199518,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - - - + + + @@ -383382,9 +199529,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - - - + + + @@ -383416,9 +199563,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + - + @@ -383427,9 +199574,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + - + @@ -383461,9 +199608,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + - + @@ -383472,9 +199619,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + - + @@ -383506,9 +199653,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + - + @@ -383517,9 +199664,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + - + @@ -383551,9 +199698,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + - + @@ -383562,9 +199709,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + - + @@ -383596,7 +199743,7 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + @@ -383607,7 +199754,7 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + @@ -383624,7 +199771,7 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + @@ -383634,7 +199781,7 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + @@ -383652,7 +199799,7 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + @@ -383663,7 +199810,7 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + @@ -383680,7 +199827,7 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + @@ -383690,101 +199837,13 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - @@ -383795,7 +199854,7 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + @@ -383806,7 +199865,7 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + @@ -383839,9 +199898,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - - - + + + @@ -383850,9 +199909,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - - - + + + @@ -383866,9 +199925,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - - - + + + @@ -383883,7 +199942,7 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + @@ -383894,7 +199953,7 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + @@ -383910,7 +199969,7 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - + @@ -383928,8 +199987,8 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - - + + @@ -383938,9 +199997,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - - - + + + @@ -383954,9 +200013,9 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase - - - + + + diff --git a/src/ontology/imports/uo_import.owl b/src/ontology/imports/uo_import.owl index 76f300b..35bff89 100644 --- a/src/ontology/imports/uo_import.owl +++ b/src/ontology/imports/uo_import.owl @@ -6,10 +6,10 @@ xmlns:xml="http://www.w3.org/XML/1998/namespace" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" - xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> + xmlns:oboInOwl="oboInOwl:"> - - 2023-12-18 + + 2022-10-20 @@ -25,15 +25,15 @@ - + - + - + - + @@ -98,9 +98,9 @@ - time derived unit "A unit which is a standard measure of the dimension in which events occur in sequence." [Wikipedia:Wikipedia] time unit + time derived unit @@ -119,9 +119,9 @@ - temperature derived unit "A unit which is a standard measure of the average kinetic energy of the particles in a sample of matter." [Wikipedia:Wikipedia] temperature unit + temperature derived unit @@ -149,12 +149,13 @@ + - m - metre "A length unit which is equal to the length of the path traveled by light in vacuum during a time interval of 1/299 792 458 of a second." [BIPM:BIPM, NIST:NIST] meter + m + metre @@ -173,17 +174,11 @@ + - - - - - - - - kg "A mass unit which is equal to the mass of the International Prototype Kilogram kept by the BIPM at Svres, France." [BIPM:BIPM, NIST:NIST] kilogram + kg @@ -191,11 +186,12 @@ + - s "A time unit which is equal to the duration of 9 192 631 770 periods of the radiation corresponding to the transition between the two hyperfine levels of the ground state of the caesium 133 atom." [BIPM:BIPM, NIST:NIST] second + s @@ -203,11 +199,12 @@ + - A "An electric current unit which is equal to the constant current which, if maintained in two straight parallel conductors of infinite length, of negligible circular cross-section, and placed 1 m apart in vacuum, would produce between these conductors a force equal to 2 x 10^[-7] newton per meter of length." [BIPM:BIPM, NIST:NIST] ampere + A @@ -215,11 +212,12 @@ + - K "A thermodynamic temperature unit which is equal to the fraction 1/273.16 of the thermodynamic temperature of the triple point of water." [BIPM:BIPM, NIST:NIST] kelvin + K @@ -227,11 +225,12 @@ + - mol "A substance unit which is equal to the amount of substance of a molecular system which contains as many elementary entities as there are atoms in 0.012 kilogram of carbon 12." [BIPM:BIPM, NIST:NIST] mole + mol @@ -239,11 +238,12 @@ + - cd "A luminous intensity unit which equal to the luminous intensity, in a given direction, of a source that emits monochromatic radiation of frequency 540 x 1012 hertz and that has a radiant intensity in that direction of 1/683 watt per steradian." [BIPM:BIPM, NIST:NIST] candela + cd @@ -262,17 +262,11 @@ - - - - - - - - centimetre - cm + "A length unit which is equal to one hundredth of a meter or 10^[-2] m." [NIST:NIST] centimeter + centimetre + cm @@ -291,17 +285,11 @@ - - - - - - - - millimetre - mm + "A length unit which is equal to one thousandth of a meter or 10^[-3] m." [NIST:NIST] millimeter + micrometre + mm @@ -320,18 +308,12 @@ - - - - - - - + + "A length unit which is equal to one millionth of a meter or 10^[-6] m." [NIST:NIST] + micrometer micrometre micron um - "A length unit which is equal to one millionth of a meter or 10^[-6] m." [NIST:NIST] - micrometer @@ -350,17 +332,11 @@ - - - - - - - - nanometre - nm + "A length unit which is equal to one thousandth of one millionth of a meter or 10^[-9] m." [NIST:NIST] nanometer + nanometre + nm @@ -368,10 +344,11 @@ + - Å "A length unit which is equal to 10 [-10] m." [NIST:NIST] angstrom + Å @@ -390,17 +367,11 @@ - - - - - - - - picometre - pm + "A length unit which is equal to 10^[-12] m." [NIST:NIST] picometer + picometre + pm @@ -408,10 +379,11 @@ + - g "A mass unit which is equal to one thousandth of a kilogram or 10^[-3] kg." [NIST:NIST] gram + g @@ -430,16 +402,10 @@ - - - - - - - - mg + "A mass unit which is equal to one thousandth of a gram or 10^[-3] g." [UOC:GVG] milligram + mg @@ -458,16 +424,10 @@ - - - - - - - - ug + "A mass unit which is equal to one millionth of a gram or 10^[-6] g." [UOC:GVG] microgram + ug @@ -486,16 +446,10 @@ - - - - - - - - ng + "A mass unit which is equal to one thousandth of one millionth of a gram or 10^[-9] g." [UOC:GVG] nanogram + ng @@ -514,16 +468,10 @@ - - - - - - - - pg + "A mass unit which is equal to 10^[-12] g." [UOC:GVG] picogram + pg @@ -542,16 +490,10 @@ - - - - - - - - fg + "A mass unit which is equal to 10^[-15] g." [NIST:NIST] femtogram + fg @@ -559,10 +501,11 @@ + - C "A temperature unit which is equal to one kelvin degree. However, they have their zeros at different points. The centigrade scale has its zero at 273.15 K." [NIST:NIST] degree Celsius + C @@ -581,16 +524,10 @@ - - - - - - - - ms + "A time unit which is equal to one thousandth of a second or 10^[-3] s." [NIST:NIST] millisecond + ms @@ -609,16 +546,10 @@ - - - - - - - - us + "A time unit which is equal to one millionth of a second or 10^[-6] s." [NIST:NIST] microsecond + us @@ -637,16 +568,10 @@ - - - - - - - - ps + "A time unit which is equal to 10^[-12] s." [NIST:NIST] picosecond + ps @@ -654,10 +579,11 @@ + - min "A time unit which is equal to 60 seconds." [Wikipedia:Wikipedia] minute + min @@ -665,10 +591,11 @@ + - h "A time unit which is equal to 3600 seconds or 60 minutes." [Wikipedia:Wikipedia] hour + h @@ -676,6 +603,7 @@ + "A time unit which is equal to 24 hours." [Wikipedia:Wikipedia] day @@ -686,6 +614,7 @@ + "A time unit which is equal to 7 days." [Wikipedia:Wikipedia] week @@ -696,6 +625,7 @@ + "A time unit which is approximately equal to the length of time of one of cycle of the moon's phases which in science is taken to be equal to 30 days." [Wikipedia:Wikipedia] month @@ -706,6 +636,7 @@ + "A time unit which is equal to 12 months which in science is taken to be equal to 365.25 days." [Wikipedia:Wikipedia] year @@ -727,16 +658,10 @@ - - - - - - - - mA + "An electric current unit current which is equal to one thousandth of an ampere or 10^[-3] A." [UOC:GVG] milliampere + mA @@ -755,16 +680,10 @@ - - - - - - - - uA + "An electric current unit current which is equal to one millionth of an ampere or 10^[-6] A." [UOC:GVG] microampere + uA @@ -783,16 +702,10 @@ - - - - - - - - umol + "A substance unit equal to a millionth of a mol or 10^[-6] mol." [NIST:NIST] micromole + umol @@ -811,16 +724,10 @@ - - - - - - - - mmol + "A substance unit equal to a thousandth of a mol or 10^[-3] mol." [NIST:NIST] millimole + mmol @@ -839,16 +746,10 @@ - - - - - - - - nmol + "A substance unit equal to one thousandth of one millionth of a mole or 10^[-9] mol." [NIST:NIST] nanomole + nmol @@ -867,16 +768,10 @@ - - - - - - - - pmol + "A substance unit equal to 10^[-12] mol." [NIST:NIST] picomole + pmol @@ -895,16 +790,10 @@ - - - - - - - - fmol + "A substance unit equal to 10^[-15] mol." [NIST:NIST] femtomole + fmol @@ -923,16 +812,10 @@ - - - - - - - - amol + "A substance unit equal to 10^[-18] mol." [NIST:NIST] attomole + amol @@ -1009,9 +892,9 @@ - mass per unit volume "A density unit which is a standard measure of the mass of a substance in a given volume." [UOC:GVG] mass density unit + mass per unit volume @@ -1030,9 +913,9 @@ - mass per unit area unit "A density unit which is a standard measure of the mass exerting an influence on a given area." [Wikipedia:Wikipedia] area density unit + mass per unit area unit @@ -1110,10 +993,11 @@ + - M "A unit of concentration which expresses a concentration of 1 mole of solute per liter of solution (mol/L)." [UOC:GVG] molar + M @@ -1132,16 +1016,10 @@ - - - - - - - - mM + "A unit of molarity which is equal to one thousandth of a molar or 10^[-3] M." [UOC:GVG] millimolar + mM @@ -1160,16 +1038,10 @@ - - - - - - - - uM + "A unit of molarity which is equal to one millionth of a molar or 10^[-6] M." [UOC:GVG] micromolar + uM @@ -1188,16 +1060,10 @@ - - - - - - - - nM + "A unit of molarity which is equal to one thousandth of one millionth of a molar or 10^[-9] M." [UOC:GVG] nanomolar + nM @@ -1216,16 +1082,10 @@ - - - - - - - - pM + "A unit of molarity which is equal to 10^[-12] M." [UOC:GVG] picomolar + pM @@ -1243,10 +1103,11 @@ + - m "A unit of concentration which expresses a concentration of a solution of 1 mole per kilogram of solvent (mol/kg)." [UOC:GVG] molal + m @@ -1265,16 +1126,10 @@ - - - - - - - - mm + "A molality unit which is equal to one thousandth of a molal or 10^[-3] m." [UOC:GVG] millimolal + mm @@ -1293,16 +1148,10 @@ - - - - - - - - um + "A molality unit which is equal to one millionth of a molal or 10^[-6] m." [UOC:GVG] micromolal + um @@ -1321,16 +1170,10 @@ - - - - - - - - nm + "A molality unit which is equal to one thousandth of one millionth of a molal or 10^[-9] m." [UOC:GVG] nanomolal + nm @@ -1349,16 +1192,10 @@ - - - - - - - - pm + "A molality unit which is equal to 10^[-12] m." [UOC:GVG] picomolal + pm @@ -1377,16 +1214,10 @@ - - - - - - - - fM + "A unit of molarity which is equal to 10^[-15] M." [UOC:GVG] femtomolar + fM @@ -1404,10 +1235,11 @@ + - N "A unit of concentration which is one gram equivalent of a solute per liter of solution. A gram equivalent weight or equivalent is a measure of the reactive capacity of a given molecule." [Wikipedia:Wikipedia] normal + N @@ -1415,11 +1247,13 @@ + + - (x) - chi "A concentration unit which denotes the number of moles of solute as a proportion of the total number of moles in a solution." [Wikipedia:Wikipedia] mole fraction + (x) + chi @@ -1427,11 +1261,12 @@ + - m/s^[2] - metre per second per second "An acceleration unit which is equal to the acceleration an object changing its velocity by 1meter/s over a time period that equals one second." [NIST:NIST] meter per second per second + m/s^[2] + metre per second per second @@ -1439,11 +1274,12 @@ + - alpha - rad/s^[2] "An angular unit acceleration which is equal to the angular acceleration of an object changing its angular velocity by 1rad/s over a time period that equals one second." [NIST:NIST] radian per second per second + alpha + rad/s^[2] @@ -1451,10 +1287,11 @@ + - rad/s "An angular unit velocity which is equal to about 9.54930 rpm (revolutions per minute)." [NIST:NIST] radian per second + rad/s @@ -1462,11 +1299,12 @@ + - m^[2] - square metre "An area unit which is equal to an area enclosed by a square with sides each 1 meter long." [NIST:NIST] square meter + m^[2] + square metre @@ -1474,11 +1312,12 @@ + - cm^[2] - square centimetre "An area unit which is equal to one ten thousandth of a square meter or 10^[-4] m^[2]." [NIST:NIST] square centimeter + cm^[2] + square centimetre @@ -1486,11 +1325,12 @@ + - mm^[2] - square millimetre "An area unit which is equal to one millionth of a square meter or 10^[-6] m^[2]." [NIST:NIST] square millimeter + mm^[2] + square millimetre @@ -1499,10 +1339,10 @@ - kg/m^[3] - kilogram per cubic metre "A mass unit density which is equal to mass of an object in kilograms divided by the volume in cubic meters." [UOC:GVG] kilogram per cubic meter + kg/m^[3] + kilogram per cubic metre @@ -1510,11 +1350,12 @@ + - g/cm^[3] - gram per cubic centimetre "A mass unit density which is equal to mass of an object in grams divided by the volume in cubic centimeters." [UOC:GVG] gram per cubic centimeter + g/cm^[3] + gram per cubic centimetre @@ -1522,11 +1363,12 @@ + - candela per square metre - cd/m^[2] "A luminance unit which is equal to a luminous intensity of one candela radiating from a surface whose area is one square meter." [NIST:NIST] candela per square meter + candela per square metre + cd/m^[2] @@ -1545,17 +1387,12 @@ - - - - - - - - kg/m^[2] - kilogram per square metre + "An area density unit which is equal to the mass of an object in kilograms divided by the surface area in meters squared." [NIST:NIST] kilogram per square meter + Body Mass Index (BMI) + kg/m^[2] + kilogram per square metre @@ -1574,16 +1411,10 @@ - - - - - - - - kg/mol + "A molar mass unit which is equal to one kilogram of mass of one mole of chemical element or chemical compound." [NIST:NIST] kilogram per mole + kg/mol @@ -1591,10 +1422,11 @@ + - g/mol "A molar mass unit which is equal to one gram of mass of one mole of chemical element or chemical compound." [NIST:NIST] gram per mole + g/mol @@ -1602,11 +1434,12 @@ + - cubic metre per mole - m^[3]/mol "A molar volume unit which is equal to 1 cubic meter occupied by one mole of a substance in the form of a solid, liquid, or gas." [NIST:NIST] cubic meter per mole + cubic metre per mole + m^[3]/mol @@ -1614,11 +1447,12 @@ + - cm^[3]/mol - cubic centimetre per mole "A molar volume unit which is equal to 1 cubic centimeter occupied by one mole of a substance in the form of a solid, liquid, or gas." [NIST:NIST] cubic centimeter per mole + cm^[3]/mol + cubic centimetre per mole @@ -1627,10 +1461,10 @@ - kg.m/s - kilogram metre per second "A momentum unit which is equal to the momentum of a one kilogram mass object with a speed of one meter per second." [NIST:NIST] kilogram meter per second + kg.m/s + kilogram metre per second @@ -1638,11 +1472,12 @@ + - 1/s - one turn per second "A rotational frequency unit which is equal to the number complete turn in a period of time that equals to 1 second." [NIST:NIST] turns per second + 1/s + one turn per second @@ -1650,11 +1485,12 @@ + - cubic metre per kilogram - m^[3]/kg "A specific volume unit which is equal to one cubic meter volume occupied by one kilogram of a particular substance." [NIST:NIST] cubic meter per kilogram + cubic metre per kilogram + m^[3]/kg @@ -1662,11 +1498,12 @@ + - m/s - metre per second "A speed/velocity unit which is equal to the speed of an object traveling 1 meter distance in one second." [NIST:NIST] meter per second + m/s + metre per second @@ -1684,11 +1521,12 @@ + - cubic metre - m^[3] "A volume unit which is equal to the volume of a cube with edges one meter in length. One cubic meter equals to 1000 liters." [NIST:NIST] cubic meter + cubic metre + m^[3] @@ -1696,12 +1534,13 @@ + + "A volume unit which is equal to one millionth of a cubic meter or 10^[-9] m^[3], or to 1 ml." [NIST:NIST] + cubic centimeter cc cm^3 cubic centimetre - "A volume unit which is equal to one millionth of a cubic meter or 10^[-9] m^[3], or to 1 ml." [NIST:NIST] - cubic centimeter @@ -1720,17 +1559,11 @@ - - - - - - - - millilitre - ml + "A volume unit which is equal to one thousandth of a liter or 10^[-3] L, or to 1 cubic centimeter." [NIST:NIST] milliliter + millilitre + ml @@ -1738,12 +1571,13 @@ + + "A volume unit which is equal to one thousandth of a cubic meter or 10^[-3] m^[3], or to 1 decimeter." [NIST:NIST] + liter L l litre - "A volume unit which is equal to one thousandth of a cubic meter or 10^[-3] m^[3], or to 1 decimeter." [NIST:NIST] - liter @@ -1751,11 +1585,12 @@ + - cubic decimetre - dm^[3] "A volume unit which is equal to one thousand of a cubic meter or 10^[-3] m^[3], or to 1 L." [NIST:NIST] cubic decimeter + cubic decimetre + dm^[3] @@ -1774,17 +1609,11 @@ - - - - - - - - microlitre - ul + "A volume unit which is equal to one millionth of a liter or 10^[-6] L." [NIST:NIST] microliter + microlitre + ul @@ -1803,17 +1632,11 @@ - - - - - - - - nanolitre - nl + "A volume unit which is equal to one thousandth of one millionth of a liter or 10^[-9] L." [NIST:NIST] nanoliter + nanolitre + nl @@ -1832,17 +1655,11 @@ - - - - - - - - picolitre - pl + "A volume unit which is equal to 10^[-12] L." [NIST:NIST] picoliter + picolitre + pl @@ -1861,17 +1678,11 @@ - - - - - - - - femtolitre - fl + "A volume unit which is equal to 10^[-15] L." [NIST:NIST] femtoliter + femtolitre + fl @@ -1889,11 +1700,12 @@ + - Hz - s^1 "A frequency unit which is equal to 1 complete cycle of a recurring phenomenon in 1 second." [NIST:NIST] hertz + Hz + s^1 @@ -1911,10 +1723,11 @@ + - N "A force unit which is equal to the force required to cause an acceleration of 1m/s2 of a mass of 1 Kg in the direction of the force." [NIST:NIST] newton + N @@ -1932,10 +1745,11 @@ + - Pa "A pressure unit which is equal to the pressure or stress on a surface caused by a force of 1 newton spread over a surface of 1 m^[2]." [NIST:NIST] pascal + Pa @@ -1953,10 +1767,11 @@ + - J "An energy unit which is equal to the energy required when a force of 1 newton moves an object 1 meter in the direction of the force." [NIST:NIST] joule + J @@ -1974,10 +1789,11 @@ + - W "A power unit which is equal to the power used when work is done at the rate of 1 joule per second." [NIST:NIST] watt + W @@ -1995,10 +1811,11 @@ + - lx "An illuminance unit which is equal to the illuminance produced by 1 lumen evenly spread over an area 1 m^[2]." [NIST:NIST] lux + lx @@ -2016,10 +1833,11 @@ + - lm "A luminous flux unit which is equal to the luminous flux emitted into 1 steradian by a point source of 1 candela." [NIST:NIST] lumen + lm @@ -2037,10 +1855,11 @@ + - kat "A catalytic unit activity which is equal to the activity of a catalyst in moles per second, such as the amount of an enzyme needed to transform one mole of substrate per second." [NIST:NIST] katal + kat @@ -2068,10 +1887,11 @@ + - rad "A plane angle unit which is equal to the angle subtended at the center of a circle by an arc equal in length to the radius of the circle, approximately 57 degrees 17 minutes and 44.6 seconds." [NIST:NIST] radian + rad @@ -2089,10 +1909,11 @@ + - sr "A solid angle unit which is equal to the solid angle subtended at the center of a sphere by an area on the surface of the sphere that is equal to the radius squared." [NIST:NIST] steradian + sr @@ -2150,10 +1971,11 @@ + - Bq "An activity (of a radionuclide) unit which is equal to the activity of a quantity of radioactive material in which one nucleus decays per second or there is one atom disintegration per second (dps)." [NIST:NIST] becquerel + Bq @@ -2161,10 +1983,11 @@ + - Ci "An activity (of a radionuclide) unit which is equal to the activity of a quantity of radioactive material in which there are 3.7 x 10^[10] atom disintegration per second (dps)." [ORCBS:ORCBS] curie + Ci @@ -2172,10 +1995,11 @@ + - Gy "An absorbed dose unit which is equal to the absorption of one joule of radiation energy by one kilogram of matter." [NIST:NIST] gray + Gy @@ -2183,6 +2007,7 @@ + "An absorbed dose unit which is equal to 0.01 gray (Gy)." [Wikipedia:Wikipedia] rad @@ -2193,10 +2018,11 @@ + - R "An exposure unit which is equal to the amount of radiation required to liberate positive and negative charges of one electrostatic unit of charge in 1 cm^[3] of air at standard temperature and pressure (STP). This corresponds to the generation of approximately 2.0810^[9] ion pairs." [Wikipedia:Wikipedia] roentgen + R @@ -2204,10 +2030,11 @@ + - Sv "A dose equivalent unit which is equal to the absorption of one joule of radiation energy by one kilogram of matter." [NIST:NIST] sievert + Sv @@ -2226,16 +2053,10 @@ - - - - - - - - mSv + "A dose equivalent unit which is equal to one thousandth of a sievert or 10^[-3] Sv." [NIST:NIST] millisievert + mSv @@ -2254,16 +2075,10 @@ - - - - - - - - uSv + "A dose equivalent unit which is equal to one millionth of a sievert or 10^[-6] Sv." [NIST:NIST] microsievert + uSv @@ -2271,10 +2086,11 @@ + - rem "A dose equivalent unit which when multiplied by hundred is equal to one sievert or 1 Sv. 1 Sv is equal to 100 rem." [Wikipedia:Wikipedia] Roentgen equivalent man + rem @@ -2293,16 +2109,10 @@ - - - - - - - - uGy + "An absorbed dose unit which is equal to one millionth of a gray or 10^[-6] Gy." [NIST:NIST] microgray + uGy @@ -2321,16 +2131,10 @@ - - - - - - - - mGy + "An absorbed dose unit which is equal to one thousandth of a gray or 10^[-3] Gy." [NIST:NIST] milligray + mGy @@ -2349,16 +2153,10 @@ - - - - - - - - nGy + "An absorbed dose unit which is equal to one thousandth of a millionth of a gray or 10^[-9] Gy." [NIST:NIST] nanogray + nGy @@ -2377,16 +2175,10 @@ - - - - - - - - nSv + "A dose equivalent unit which is equal to one thousandth of a millionth of a sievert or 10^[-9] Sv." [NIST:NIST] nanosievert + nSv @@ -2405,16 +2197,10 @@ - - - - - - - - mCi + "An activity (of a radionuclide) unit which is equal to one thousandth of a curie or 10^[-3] Ci." [ORCBS:ORCBS] millicurie + mCi @@ -2433,16 +2219,10 @@ - - - - - - - - uCi + "An activity (of a radionuclide) unit which is equal to one millionth of a curie or 10^[-6] Ci." [ORCBS:ORCBS] microcurie + uCi @@ -2450,10 +2230,11 @@ + - dpm "An activity (of a radionuclide) unit which is equal to the activity of a quantity of radioactive material in which one nucleus decays per minute or there is one atom disintegration per minute." [ORCBS:ORCBS] disintegrations per minute + dpm @@ -2461,10 +2242,11 @@ + - cpm "An activity (of a radionuclide) unit which is equal to the number of light emissions produced by ionizing radiation in one minute." [ORCBS:ORCBS] counts per minute + cpm @@ -2483,16 +2265,10 @@ - - - - - - - - ns + "A time unit which is equal to one thousandth of one millionth of a second or 10^[-9] s." [NIST:NIST] nanosecond + ns @@ -2500,6 +2276,7 @@ + "A time unit which is equal to 100 years." [Wikipedia:Wikipedia] century @@ -2510,6 +2287,7 @@ + "A time unit which represents the period over which the activity or concentration of a specified chemical or element falls to half its original activity or concentration." [MGED:MGED] half life @@ -2520,10 +2298,11 @@ + - ft-c "An illuminance unit which is equal to the illuminance produced by 1 lumen evenly spread over an area 1 foot^[2]. One footcandle is equal to 10.76 lux." [Wikipedia:Wikipedia] foot candle + ft-c @@ -2541,11 +2320,12 @@ + - W/m^[2] - watt per square metre "An irradiance unit which is equal to 1 watt of radiant power incident per one square meter surface area." [NIST:NIST] watt per square meter + W/m^[2] + watt per square metre @@ -2553,12 +2333,13 @@ + + "An irradiance unit which is equal to one einstein per square meter per second. One einstein is one mole of photons, regardless of their frequency. Therefore, the number of photons in an einstein is Avogadro's number." [Wikipedia:Wikipedia] + einstein per square meter per second einstein per square metre per second einstein/sm^[2] mole per second and square meter mol/sm^2 - "An irradiance unit which is equal to one einstein per square meter per second. One einstein is one mole of photons, regardless of their frequency. Therefore, the number of photons in an einstein is Avogadro's number." [Wikipedia:Wikipedia] - einstein per square meter per second @@ -2576,11 +2357,12 @@ + - W/sr m^[2] - watt per steradian per square metre "A radiance unit which is equal to one watt of radiant power incident per steradian solid angle per one square meter projected area of the source, as viewed from the given direction." [NIST:NIST] watt per steradian per square meter + W/sr m^[2] + watt per steradian per square metre @@ -2609,18 +2391,12 @@ - - - - - - - + + "An irradiance unit which is equal to one microeinstein per square meter per second or 10^[-6] microeinstein/sm^[2]." [Wikipedia:Wikipedia] + microeinstein per square meter per second microeinstein per square metre per second micromole per second and square meter mmol/sm^2 umicroeinstein/sm^[2] - "An irradiance unit which is equal to one microeinstein per square meter per second or 10^[-6] microeinstein/sm^[2]." [Wikipedia:Wikipedia] - microeinstein per square meter per second @@ -2638,10 +2414,11 @@ + - W/sr "A radiant intensity unit which is equal to one kilogram meter squared per second cubed per steradian." [NIST:NIST] watt per steradian + W/sr @@ -2649,11 +2426,13 @@ + + - w/w - weight-weight percentage "A dimensionless concentration unit which denotes the mass of a substance in a mixture as a percentage of the mass of the entire mixture." [Wikipedia:Wikipedia] mass percentage + w/w + weight-weight percentage @@ -2661,11 +2440,13 @@ + + - (w/v) - weight-volume percentage "A dimensionless concentration unit which denotes the mass of the substance in a mixture as a percentage of the volume of the entire mixture." [UOC:GVG] mass volume percentage + (w/v) + weight-volume percentage @@ -2673,10 +2454,12 @@ + + - % (v/v) "A dimensionless concentration unit which denotes the volume of the solute in mL per 100 mL of the resulting solution." [UOC:GVG] volume percentage + % (v/v) @@ -2694,11 +2477,12 @@ + - 10^[-2] - pph "A dimensionless concentration notation which denotes the amount of a given substance in a total amount of 100 regardless of the units of measure as long as they are the same." [UOC:GVG] parts per hundred + 10^[-2] + pph @@ -2706,11 +2490,12 @@ + - 10^[-3] - ppth "A dimensionless concentration notation which denotes the amount of a given substance in a total amount of 1000 regardless of the units of measure as long as they are the same." [UOC:GVG] parts per thousand + 10^[-3] + ppth @@ -2718,11 +2503,12 @@ + - 10^[-6] - ppm "A dimensionless concentration notation which denotes the amount of a given substance in a total amount of 1,000,000 regardless of the units of measure used as long as they are the same or 1 part in 10^[6]." [UOC:GVG] parts per million + 10^[-6] + ppm @@ -2730,11 +2516,12 @@ + - 10^[-9] - ppb "A dimensionless concentration notation which denotes the amount of a given substance in a total amount of 1,000,000,000 regardless of the units of measure as long as they are the same or 1 part in 10^[9]." [UOC:GVG] parts per billion + 10^[-9] + ppb @@ -2742,11 +2529,12 @@ + - 10^[-12] - ppt "A dimensionless concentration notation which denotes the amount of a given substance in a total amount of 1,000,000,000 regardless of the units of measure used as long as they are the same or 1 part in 10^[12]." [UOC:GVG] parts per trillion + 10^[-12] + ppt @@ -2754,11 +2542,12 @@ + - 10^[-15] - ppq "A dimensionless concentration notation which denotes the amount of a given substance in a total amount of 1,000,000,000,000 regardless of the units of measure used as long as they are the same or 1 part in 10^[15]." [UOC:GVG] parts per quadrillion + 10^[-15] + ppq @@ -2766,11 +2555,12 @@ + - g/ml - gram per millilitre "A mass unit density which is equal to mass of an object in grams divided by the volume in milliliter." [UOC:GVG] gram per milliliter + g/ml + gram per millilitre @@ -2789,17 +2579,11 @@ - - - - - - - - kg/L - kilogram per litre + "A mass unit density which is equal to mass of an object in kilograms divided by the volume in liters." [UOC:GVG] kilogram per liter + kg/L + kilogram per litre @@ -2807,12 +2591,13 @@ + - g/L - gram per litre "A mass unit density which is equal to mass of an object in grams divided by the volume in liters." [UOC:GVG] gram per liter - + g/L + gram per litre + @@ -2830,17 +2615,11 @@ - - - - - - - - mg/ml - milligram per millilitre + "A mass unit density which is equal to mass of an object in milligrams divided by the volume in milliliters." [UOC:GVG] milligram per milliliter + mg/ml + milligram per millilitre @@ -2858,11 +2637,12 @@ + - U/ml - unit per millilitre "A unit per milliliter unit which is equal to one unit of an agreed arbitrary amount per one milliliter." [Webmd:Webmd] unit per milliliter + U/ml + unit per millilitre @@ -2870,11 +2650,12 @@ + - U/l - unit per litre "A unit per milliliter unit which is equal to one unit of an agreed arbitrary amount per one liter." [UOC:GVG] unit per liter + U/l + unit per litre @@ -2882,6 +2663,7 @@ + "A concentration unit which is a standard measure of the mass of a substance in a given volume (density)." [Wikipedia:Wikipedia] mass per unit volume @@ -2892,10 +2674,11 @@ + - U "A catalytic unit activity which is equal to the amount of the enzyme that catalyzes the conversion of 1 micro mole of substrate per minute." [Wikipedia:Wikipedia] enzyme unit + U @@ -2924,10 +2707,10 @@ - kg/m - kilogram per metre "An area density unit which is equal to the mass of an object in kilograms divided by one meter." [NIST:NIST] kilogram per meter + kg/m + kilogram per metre @@ -2935,6 +2718,7 @@ + "A plane angle unit which is equal to 1/360 of a full rotation or 1.7453310^[-2] rad." [Wikipedia:Wikipedia] degree @@ -2956,9 +2740,9 @@ - % "A dimensionless ratio unit which denotes numbers as fractions of 100." [Wikipedia:Wikipedia] percent + % @@ -2966,6 +2750,7 @@ + "A dimensionless unit which denoted an irrational real number, approximately equal to 3.14159 which is the ratio of a circle's circumference to its diameter in Euclidean geometry." [Wikipedia:Wikipedia] pi @@ -2977,9 +2762,9 @@ - count "A dimensionless unit which denotes a simple count of things." [MGED:MGED] count unit + count @@ -2989,7 +2774,7 @@ "A dimensionless unit which denotes an amount or magnitude of one quantity relative to another." [Wikipedia:Wikipedia] - ratio unit + ratio @@ -3007,6 +2792,7 @@ + "A dimensionless count unit which denotes the number of molecules." [MGED:MGED] molecule count @@ -3017,6 +2803,7 @@ + "A dimensionless percent unit which denotes the homogeneity of a biomaterial." [MGED:MGED] purity percentage @@ -3027,6 +2814,7 @@ + "A dimensionless percent unit which denotes the density of an attached or monolayer culture (e.g., cell culture)." [MGED:MGED] confluence percentage @@ -3037,10 +2825,11 @@ + - F "A temperature unit which is equal to 5/9ths of a kelvin. Negative 40 degrees Fahrenheit is equal to negative 40 degrees Celsius." [Wikipedia:Wikipedia] degree Fahrenheit + F @@ -3048,6 +2837,8 @@ + + "A dimensionless concentration notation which denotes the acidity of a solution in terms of activity of hydrogen ions (H+)." [Wikipedia:Wikipedia] pH @@ -3058,11 +2849,12 @@ + - l/kg - litre per kilogram "A specific volume unit which is equal to one liter volume occupied by one kilogram of a particular substance." [NIST:NIST] liter per kilogram + l/kg + litre per kilogram @@ -3081,17 +2873,11 @@ - - - - - - - - millilitre per kilogram - ml/kg + "A specific volume unit which is equal to a thousandth of a liter per kilogram or 10^[-3] l/kg." [NIST:NIST] milliliter per kilogram + millilitre per kilogram + ml/kg @@ -3110,17 +2896,11 @@ - - - - - - - - microlitre per kilogram - ul/kg + "A specific volume unit which is equal to one millionth of a liter per kilogram or 10^[-6] l/kg." [NIST:NIST] microliter per kilogram + microlitre per kilogram + ul/kg @@ -3138,11 +2918,12 @@ + - cells per millilitre - cells per ml "A unit of cell concentration which is equal to one cell in a volume of 1 milliliter." [Bioedonline:Bioedonline] cells per milliliter + cells per millilitre + cells per ml @@ -3160,11 +2941,12 @@ + - kat/m^[3] - katal per cubic metre "A catalytic (activity) concentration unit which is equal to 1 katal activity of a catalyst in a given volume of one cubic meter." [NIST:NIST] katal per cubic meter + kat/m^[3] + katal per cubic metre @@ -3172,11 +2954,12 @@ + - kat/l - katal per litre "A catalytic (activity) concentration unit which is equal to 1 katal activity of a catalyst in a given volume of one thousandth of a cubic meter." [NIST:NIST] katal per liter + kat/l + katal per litre @@ -3195,10 +2978,10 @@ - millilitre per cubic metre - ml/m^[3] "A volume per unit volume unit which is equal to one millionth of a liter of solute in one cubic meter of solution." [NIST:NIST] milliliter per cubic meter + millilitre per cubic metre + ml/m^[3] @@ -3207,10 +2990,10 @@ - millilitre per litre - ml/l "A volume per unit volume unit which is equal to one millionth of a liter of solute in one liter of solution." [NIST:NIST] milliliter per liter + millilitre per litre + ml/l @@ -3218,11 +3001,12 @@ + - g/dl - gram per decilitre "A mass density unit which is equal to mass of an object in grams divided by the volume in deciliters." [UOC:GVG] gram per deciliter + g/dl + gram per decilitre @@ -3241,17 +3025,11 @@ - - - - - - - - decilitre - dl + "A volume unit which is equal to one tenth of a liter or 10^[-1] L." [NIST:NIST] deciliter + decilitre + dl @@ -3259,10 +3037,11 @@ + - cfu "A dimensionless count unit which a measure of viable bacterial numbers." [Wikipedia:Wikipedia] colony forming unit + cfu @@ -3270,10 +3049,11 @@ + - pfu - "A dimensionless count unit which a measure of plaque forming units in a given volume." [Wikipedia:Wikipedia] + "A dimensionless count unit which a measure of plague forming units in a given volume." [Wikipedia:Wikipedia] plaque forming unit + pfu @@ -3291,11 +3071,12 @@ + - cfu/ml - colony forming unit per millilitre "A colony forming unit which a measure of viable bacterial numbers in one milliliter." [Wikipedia:Wikipedia] colony forming unit per milliliter + cfu/ml + colony forming unit per millilitre @@ -3304,7 +3085,7 @@ - "A concentration unit which a measure of plaque forming units in a given volume." [UOC:GVG] + "A concentration unit which a measure of plague forming units in a given volume." [UOC:GVG] plaque forming unit per volume @@ -3313,11 +3094,12 @@ + + "A concentration unit which a measure of plague forming units in one milliliter." [UOC:GVG] + plaque forming unit per milliliter pfu/ml plaque forming unit per millilitre - "A concentration unit which a measure of plaque forming units in one milliliter." [UOC:GVG] - plaque forming unit per milliliter @@ -3325,10 +3107,11 @@ + - dps "An activity (of a radionuclide) unit which is equal to the activity of a quantity of radioactive material in which one nucleus decays per second or there is one atom disintegration per second." [ORCBS:ORCBS] disintegrations per second + dps @@ -3346,10 +3129,11 @@ + - V "An electric potential difference unit which is equal to the work per unit charge. One volt is the potential difference required to move one coulomb of charge between two points in a circuit while using one joule of energy." [Wikipedia:Wikipedia] volt + V @@ -3367,10 +3151,11 @@ + - C "An electrical charge unit which is equal to the amount of charge transferred by a current of 1 ampere in 1 second." [WordNet:WordNet] coulomb + C @@ -3378,13 +3163,14 @@ + + "An independently to the base SI units defined mass unit which is equal to one twelfth of the mass of an unbound atom of the carbon-12 nuclide, at rest and in its ground state." [Wikipedia:Wikipedia] + dalton Da amu u unified atomic mass unit - "An independently to the base SI units defined mass unit which is equal to one twelfth of the mass of an unbound atom of the carbon-12 nuclide, at rest and in its ground state." [Wikipedia:Wikipedia] - dalton @@ -3403,16 +3189,10 @@ - - - - - - - - kDa + "A mass unit which is equal to one thousand daltons." [Wikipedia:Wikipedia] kilodalton + kDa @@ -3420,10 +3200,11 @@ + - Wh "An energy unit which is equal to the amount of electrical energy equivalent to a one-watt load drawing power for one hour." [Wikipedia:Wikipedia] watt-hour + Wh @@ -3442,13 +3223,7 @@ - - - - - - - + "An energy unit which is equal to 1,000 watt-hours." [Wikipedia:Wikipedia] kilowatt-hour @@ -3468,12 +3243,13 @@ + + "A magnetic flux unit which is equal to the amount of flux that when linked with a single turn of wire for an interval of one second will induce an electromotive force of one volt." [ScienceLobby:ScienceLobby] + weber V s Wb volt-second - "A magnetic flux unit which is equal to the amount of flux that when linked with a single turn of wire for an interval of one second will induce an electromotive force of one volt." [ScienceLobby:ScienceLobby] - weber @@ -3482,9 +3258,9 @@ - B "A unit which is a standard measure of the strength of a magnetic field." [allnet:allnet] magnetic flux density unit + B @@ -3492,11 +3268,12 @@ + - T - Wb/m2 "A magnetic flux density unit which is equal to one weber per square meter." [WordNet:WordNet] tesla + T + Wb/m2 @@ -3504,10 +3281,11 @@ + - Vh "A magnetic flux unit which is equal to 3600 Wb." [UOC:GVG] volt-hour + Vh @@ -3526,16 +3304,10 @@ - - - - - - - - kVh + "A magnetic flux unit which is equal to one thousand volt-hours." [UOC:GVG] kilovolt-hour + kVh @@ -3553,6 +3325,7 @@ + "An information unit which refers to a digit in the binary numeral system, which consists of base 2 digits (ie there are only 2 possible values: 0 or 1)." [Wikipedia:Wikipedia] bit @@ -3563,10 +3336,11 @@ + - B "An information unit which is equal to 8 bits." [Wikipedia:Wikipedia] byte + B @@ -3585,16 +3359,10 @@ - - - - - - - - kB + "An information unit which is equal to 1000 bytes." [Wikipedia:Wikipedia] kilobyte + kB @@ -3613,16 +3381,10 @@ - - - - - - - - MB + "An information unit which is equal to 1000 kB." [Wikipedia:Wikipedia] megabyte + MB @@ -3640,6 +3402,7 @@ + "An image resolution unit which is a standard measure of the amount of spatial detail in an image." [Wikipedia:Wikipedia] chroma sampling unit @@ -3650,6 +3413,7 @@ + "An image resolution unit which is a standard measure of the amount of contrast available in a pixel." [Wikipedia:Wikipedia] dynamic range unit @@ -3670,10 +3434,11 @@ + - dpi "A spatial resolution unit which is a standard measure of the printing resolution, in particular the number of individual dots of ink a printer or toner can produce within a linear one-inch space." [Wikipedia:Wikipedia] dots per inch + dpi @@ -3682,9 +3447,9 @@ - micrometer pixel "A spatial resolution unit which is equal to a pixel size of one micrometer." [Wikipedia:Wikipedia] micron pixel + micrometer pixel @@ -3692,11 +3457,12 @@ + - pixel density - ppi "A spatial resolution unit which is a standard measure of the resolution of a computer display, related to the size of the display in inches and the total number of pixels in the horizontal and vertical directions." [Wikipedia:Wikipedia] pixels per inch + pixel density + ppi @@ -3704,10 +3470,11 @@ + - pixels per millimetre "A spatial resolution unit which is a standard measure of the number of pixels in one millimeter length or width of a digital image divided by the physical length or width of a printed image." [Wikipedia:Wikipedia] pixels per millimeter + pixels per millimetre @@ -3715,11 +3482,12 @@ + - basepair - bp "A count unit which contains one nucleotide." [UO:GVG] base pair + basepair + bp @@ -3727,10 +3495,11 @@ + - KiB "An information unit which is equal to 1024 B." [NIST:NIST] kibibyte + KiB @@ -3738,10 +3507,11 @@ + - MiB "An information unit which is equal to 1024 KiB." [NIST:NIST] mebibyte + MiB @@ -3760,16 +3530,10 @@ - - - - - - - - mV + "An electric potential difference unit which is equal to one thousandth of a volt or 10^[-3] V." [UOC:GVG] millivolt + mV @@ -3788,16 +3552,10 @@ - - - - - - - - kV + "An electric potential difference unit which is equal to one thousand volts or 10^[3] V." [UOC:GVG] kilovolt + kV @@ -3816,16 +3574,10 @@ - - - - - - - - uV + "An electric potential difference unit which is equal to one millionth of a volt or 10^[-6] V." [UOC:GVG] microvolt + uV @@ -3844,16 +3596,10 @@ - - - - - - - - nV + "An electric potential difference unit which is equal to one billionth of a volt or 10^[-12] V." [UOC:GVG] nanovolt + nV @@ -3872,16 +3618,10 @@ - - - - - - - - pV + "An electric potential difference unit which is equal to one trillionth of a volt or 10^[-12] V." [UOC:GVG] picovolt + pV @@ -3900,16 +3640,10 @@ - - - - - - - - MV + "An electric potential difference unit which is equal to one million volts or 10^[6] V." [UOC:GVG] megavolt + MV @@ -3927,11 +3661,12 @@ + - N/m - newton per metre "A surface tension unit which is equal to one newton per meter." [NIST:NIST] newton per meter + N/m + newton per metre @@ -3939,10 +3674,11 @@ + - dyn/cm "A surface tension unit which is equal to one dyne per centimeter." [Wikipedia:Wikipedia] dyne per cm + dyn/cm @@ -3960,10 +3696,11 @@ + - Pa s "A viscosity unit which is equal to one pascale per second." [NIST:NIST] pascal second + Pa s @@ -3971,11 +3708,12 @@ + - P - dyne s/cm^2 "A viscosity unit which is equal to one dyne second per square centimeter." [Wikipedia:Wikipedia] poise + P + dyne s/cm^2 @@ -3984,9 +3722,9 @@ - dB "A ratio unit which is an indicator of sound power per unit area." [techtarget:techtarget] decibel + dB @@ -3994,6 +3732,7 @@ + "A unit which is a standard measure of the estimate of the stochastic effect that a non-uniform radiation dose has on a human." [Wikipedia:Wikipedia] effective dose unit @@ -4034,12 +3773,13 @@ + + "An electrical conduction unit which is equal to A/V." [NIST:NIST] + siemens A V^-1 mho S - "An electrical conduction unit which is equal to A/V." [NIST:NIST] - siemens @@ -4047,11 +3787,12 @@ + - W/m K - watt per metre kelvin "An heat conduction unit which is equal to one watt divided by meter kelvin." [NIST:NIST] watt per meter kelvin + W/m K + watt per metre kelvin @@ -4059,11 +3800,12 @@ + - eV - electron volt "A non-SI unit of energy (eV) defined as the energy acquired by a single unbound electron when it passes through an electrostatic potential difference of one volt. An electronvolt is equal to 1.602 176 53(14) x 10^-19 J." [Wikipedia:Wikipedia] electronvolt + eV + electron volt @@ -4072,9 +3814,9 @@ - E-field strength "The electric field strength is a unit which is a measure of the potential difference between two points some distance apart." [Wikipedia:http\://en.wikipedia.org/wiki/Electric_field] electric field strength unit + E-field strength @@ -4082,11 +3824,12 @@ + - V/m - volt per metre "The volt per meter is a unit of electric field strength equal to the a potential difference of 1 volt existing between two points that are 1 meter apart." [Wikipedia:http\://en.wikipedia.org/wiki/Electric_field] volt per meter + V/m + volt per metre @@ -4094,10 +3837,11 @@ + - AU "A dimensionless logarithmic unit assigned to a measure of absorbance of light through a partially absorbing substance, defined as -log10(I/I_0) where I = transmitted light and I_0 = incident light." [Wikipedia:http\://en.wikipedia.org/wiki/Absorbance] absorbance unit + AU @@ -4116,10 +3860,10 @@ - microlitres per minute - uL/min "A volumetric flow rate unit which is equal to one microliter volume through a given surface in one minute." [UOC:GVG] microliters per minute + microlitres per minute + uL/min @@ -4128,10 +3872,10 @@ - millimeters of mercury - mmHg "A unit of pressure equal to the amount of fluid pressure one millimeter deep in mercury at zero degrees centigrade on Earth." [url:en.wiktionary.org/wiki/mmHg] millimetres of mercury + millimeters of mercury + mmHg @@ -4150,17 +3894,11 @@ - - - - - - - - mg/L - milligram per litre + "A mass unit density which is equal to mass of an object in milligrams divided by the volume in liters." [UOC:GVG] milligram per liter + mg/L + milligram per litre @@ -4179,19 +3917,11 @@ - - - - - - - - mcg/mL - microgram per millilitre - ug/ml - µg/mL + "A mass unit density which is equal to mass of an object in micrograms divided by the volume in millliters." [UOC:GVG] microgram per milliliter + microgram per millilitre + ug/ml @@ -4210,17 +3940,11 @@ - - - - - - - - nanogram per millilitre - ng/ml + "A mass unit density which is equal to mass of an object in nanograms divided by the volume in milliliters." [UOC:GVG] nanogram per milliliter + nanogram per millilitre + ng/ml @@ -4229,10 +3953,10 @@ - mU/ml - milliunits per millilitre "A unit per milliliter unit which is equal to one thousandth of a unit of an agreed arbitrary amount per one milliliter." [UOC:GVG] milliunits per milliliter + mU/ml + milliunits per millilitre @@ -4250,10 +3974,11 @@ + - nM^-1 s^-1 "A rate unit which is equal to one over one nanomolar second." [UOC:GVG] count per nanomolar second + nM^-1 s^-1 @@ -4261,10 +3986,11 @@ + - M^-1 s^-1 "A rate unit which is equal to one over one molar second." [UOC:GVG] count per molar second + M^-1 s^-1 @@ -4282,11 +4008,12 @@ + - 1/nM - nM^-1 "A rate unit which is equal to one over one nanomolar." [UO:GVG] count per nanomolar + 1/nM + nM^-1 @@ -4294,11 +4021,12 @@ + - 1/M - M^-1 "A rate unit which is equal to one over one molar." [UO:GVG] count per molar + 1/M + M^-1 @@ -4307,10 +4035,10 @@ - 10^[9] - G "A prefix in the metric system denoting a factor of ten to the power of 9." [UO:GVG] giga + 10^[9] + G @@ -4319,10 +4047,10 @@ - 10^[6] - M "A prefix in the metric system denoting a factor of million." [UO:GVG] mega + 10^[6] + M @@ -4331,10 +4059,10 @@ - 10^[3] - k "A prefix in the metric system denoting a factor of one thousand." [UO:GVG] kilo + 10^[3] + k @@ -4343,10 +4071,10 @@ - 10^[-1] - d "A prefix in the metric system denoting a factor of one tenth." [UO:GVG] deci + 10^[-1] + d @@ -4355,10 +4083,10 @@ - 10^[-3] - m "A prefix in the metric system denoting a factor of one thousand." [UO:GVG] milli + 10^[-3] + m @@ -4367,10 +4095,10 @@ - 10^[-2] - c "A prefix in the metric system denoting a factor of one hundred." [UO:GVG] centi + 10^[-2] + c @@ -4379,9 +4107,9 @@ - 10^[-6] "A prefix in the metric system denoting a factor of 10 to the power of -6." [UO:GVG] micro + 10^[-6] @@ -4390,10 +4118,10 @@ - 10^[-9] - n "A prefix in the metric system denoting a factor of 10 to the power of -9." [UO:GVG] nano + 10^[-9] + n @@ -4412,17 +4140,11 @@ - - - - - - - - microgram per litre - ug/L + "A mass unit density which is equal to mass of an object in micrograms divided by the volume in liters." [UOC:GVG] microgram per liter + microgram per litre + ug/L @@ -4431,10 +4153,10 @@ - 10^[-12] - n "A prefix in the metric system denoting a factor of 10 to the power of -12." [GVG:UO] pico + 10^[-12] + n @@ -4443,10 +4165,10 @@ - 10^[-15] - f "A prefix in the metric system denoting a factor of 10 to the power of -15." [UO:GVG] femto + 10^[-15] + f @@ -4455,10 +4177,10 @@ - a - 10^[-18] "A prefix in the metric system denoting a factor of 10 to the power of -18." [UO:GVG] atto + a + 10^[-18] @@ -4498,13 +4220,6 @@ - - - - - - - "A dose unit which is equal to 1 milligram of a toxic or pharmaceutical substance per square meter of surface area of the recipient subject." [UO:PC] milligram per square meter @@ -4514,6 +4229,7 @@ + "A concentration unit which is a standard measure of the amount of a toxic or pharmaceutical substance administered over time to a recipient subject, expressed in terms of the size of the subject." [UO:PC] dosage unit @@ -4524,6 +4240,7 @@ + "A derived unit which is a measure of relative light intensity, as typically measured by a luminometer, spectrophotometer, or fluorimeter in biological research applications." [UO:PC] relative light unit @@ -4555,10 +4272,9 @@ - mH - megahertz "A frequency unit which is equal to one million hertz or 10^[6] V." [UOC:GVG] megaHertz + mH @@ -4567,9 +4283,9 @@ - cM "A unit used to express distances on a genetic map. In genetic mapping, distances between markers are determined by measuring the rate of meoitic recombination between them, which increases proportionately with the distance separating them. A cM is defined as the length of an interval in which there is a 1% probability of recombination. On the average, 1 cM is roughly equivalent to 1 megabase (Mb) of DNA, although this can vary widely due to hot and cold spots of recombination." [NCBI:http\://www.ncbi.nlm.nih.gov/SCIENCE96/Glossary.html] centiMorgan + cM @@ -4578,9 +4294,9 @@ - cR "A unit of genetic map distance defined corresponding to an interval in which there is a 1% probability of X-irradiation induced breakage. To be completely specified, the unit must be qualified by the radiation in dosage in rads (e.g. cR8000), because this determines the actual breakage probability." [NCBI:http\://www.ncbi.nlm.nih.gov/SCIENCE96/Glossary.html] centiRay + cR @@ -4599,16 +4315,10 @@ - - - - - - - Mb - megabasepair "A unit equal to one million base pairs" [UOC:GVG] mega base pair + Mb + megabasepair @@ -4627,16 +4337,10 @@ - - - - - - - Gb - gigabasepair "A unit equal to one billion base pairs." [UOC:GVG] giga base pair + Gb + gigabasepair @@ -4644,10 +4348,11 @@ + - square micrometre "An area unit which is equal to an area enclosed by a square with sides each 1 micrometer long." [NIST:NIST] square micrometer + square micrometre @@ -4666,16 +4371,10 @@ - - - - - - - - mS + "An electrical conduction unit which is equal to one thousandth of a siemen or 10^[-3] siemens." [NIST:NIST] millisiemens + mS @@ -4704,9 +4403,9 @@ - mm/day "A speed/velocity unit which is equal to the speed of an object traveling 1 millimeter distance in one day." [UOB:LKSR] millimeters per day + mm/day @@ -4715,10 +4414,10 @@ - kilometre per hour - km/h "A speed/velocity unit which is equal to the speed of an object traveling 1 kilometer distance in one hour." [NIST:NIST] kilometer per hour + kilometre per hour + km/h @@ -4727,12 +4426,12 @@ + "A mass unit which is equal to 1/12 the mass of 12C" [Wikipedia:Wikipedia] + milli mDa milli unified atomic mass unit millidalton mmu - "A mass unit which is equal to 1/12 the mass of 12C" [Wikipedia:Wikipedia] - milli @@ -4740,10 +4439,11 @@ + - HA "An area unit which is equal to an area of 10,000 square meters. Equivalent to 2.471 acres." [Wikipedia:Wikipedia] hectare + HA @@ -4751,11 +4451,12 @@ + - in "A length unit which is equal to 0.0254 metres." [Wikipedia:Wikpiedia] inch + in @@ -4763,12 +4464,13 @@ + - mil - th "A length unit which is equal to 0.0254 millimetres." [Wikipedia:Wikpiedia] thou + mil + th @@ -4776,11 +4478,12 @@ + - ft "A length unit which is equal to 0.3048 metres, or 12 inches." [Wikipedia:Wikpiedia] foot + ft @@ -4788,11 +4491,12 @@ + - yd "A length unit which is equal to 0.9144 metres, or 3 feet." [Wikipedia:Wikpiedia] yard + yd @@ -4800,11 +4504,12 @@ + - ch "A length unit which is equal to 20.1168 metres, 66 feet, or 22 yards." [Wikipedia:Wikpiedia] chain + ch @@ -4812,11 +4517,12 @@ + - fur "A length unit which is equal to 20,116.8 metres, 660 feet, or 10 chains." [Wikipedia:Wikpiedia] furlong + fur @@ -4824,11 +4530,12 @@ + - mi "A length unit which is equal to 1,609.344 metres, or 8 furlongs." [Wikipedia:Wikpiedia] mile + mi @@ -4836,11 +4543,12 @@ + - lea "A length unit which is equal to 3 miles, or 4,828.032 metres" [Wikipedia:Wikpiedia] league + lea @@ -4848,6 +4556,7 @@ + "A maritime length unit is one used primarily at sea." [Wikipedia:Wikpiedia] maritime length unit @@ -4859,9 +4568,9 @@ - ftm "A maritime length unit which is equal to 6.08 feet, or 1.853184 metres" [Wikipedia:Wikpiedia] fathom + ftm @@ -4889,6 +4598,7 @@ + "An area unit which is equal to an area of 25.292,852,64 square meters, or 1 square rod." [Wikipedia:Wikipedia] perch @@ -4899,6 +4609,7 @@ + "An area unit which is equivalent to 1 furlong x 1 rod. This is equal to an area of 1,011.714,1056 square meters, or 40 square rods." [Wikipedia:Wikipedia] rood @@ -4909,6 +4620,7 @@ + "An area unit which is equivalent to 1 furlong x 1 chain. This is equal to an area of 4,046.856,4224 square meters, or 43,500 square feet." [Wikipedia:Wikipedia] acre @@ -4919,10 +4631,11 @@ + - fl oz "An imperial volume unit which is equivalent to 28.413,0625 millilitres." [Wikipedia:Wikipedia] fluid ounce + fl oz @@ -4930,10 +4643,11 @@ + - gi "An imperial volume unit which is equivalent to 142.065,3125 millilitres." [Wikipedia:Wikipedia] gill + gi @@ -4941,10 +4655,11 @@ + - pt "An imperial volume unit which is equivalent to 568.261,25 millilitres." [Wikipedia:Wikipedia] pint + pt @@ -4952,10 +4667,11 @@ + - qt "An imperial volume unit which is equivalent to 1,136.5225 millilitres, or two pints." [Wikipedia:Wikipedia] quart + qt @@ -4963,10 +4679,11 @@ + - gal "An imperial volume unit which is equivalent to 4,546.09 millilitres, or 8 pints." [Wikipedia:Wikipedia] gallon + gal @@ -4974,10 +4691,11 @@ + - gr "An imperial mass unit which is equivalent to 64.798,91 milligrams." [Wikipedia:Wikipedia] grain + gr @@ -4985,10 +4703,11 @@ + - dr "An imperial mass unit which is equivalent to 1.771,845,195,3125 grams, or 1/256 of 1 pound." [Wikipedia:Wikipedia] drachm + dr @@ -4996,10 +4715,11 @@ + - oz "An imperial mass unit which is equivalent to 28.349,523,125 grams, or 1/16 of 1 pound." [Wikipedia:Wikipedia] ounce + oz @@ -5007,10 +4727,11 @@ + - lb "An imperial mass unit which is equivalent to 453.592,37 grams." [Wikipedia:Wikipedia] pound + lb @@ -5018,10 +4739,11 @@ + - st "An imperial mass unit which is equivalent to 6,350.293,18 grams, or 14 pounds." [Wikipedia:Wikipedia] stone + st @@ -5029,11 +4751,12 @@ + - qr - qtr "An imperial mass unit which is equivalent to 12.700,586,36 kilograms, or 28 pounds." [Wikipedia:Wikipedia] quarter + qr + qtr @@ -5041,10 +4764,11 @@ + - cwt "An imperial mass unit which is equivalent to 50.802,345,44 kilograms, 112 pounds, or 8 stone." [Wikipedia:Wikipedia] hundredweight + cwt @@ -5052,10 +4776,11 @@ + - t "An imperial mass unit which is equivalent to 1,016.046,9088 kilograms, or 2,240 pounds." [Wikipedia:Wikipedia] ton + t @@ -5063,6 +4788,7 @@ + "An imperial gravitational unit which is equivalent to a mass that accelerates by 1ft/s² when a force of one pound (lbf) is exerted on it." [Wikipedia:Wikipedia] slug @@ -5073,11 +4799,12 @@ + - metric teaspoon - tsp "A metric teaspoon is a unit of measurement of volume widely used in cooking recipes and pharmaceutic prescriptions. It equals a 5mL volume." [Wikipedia:https://en.wikipedia.org/wiki/Teaspoon] teaspoon + metric teaspoon + tsp @@ -5096,15 +4823,10 @@ - - - - - - - - "DEPRECATED: Duplicate of http://purl.obolibrary.org/obo/UO_0000039. A substance unit which is equal to one millionth of a mole." [UOB:LTS] + + "A substance unit which is equal to one millionth of a mole." [UOB:LTS] micromole + mmol @@ -5112,11 +4834,12 @@ + - g/m^[2] - gram per square metre "An area density unit which is equal to the mass of an object in grams divided by the surface area in meters squared." [NIST:NIST] gram per square meter + g/m^[2] + gram per square metre @@ -5125,10 +4848,10 @@ - nanogram per microlitre - ng/ul "A mass unit density which is equal to mass of an object in nanograms divided by the volume in microliters." [UOB:LTS] nanogram per microliter + nanogram per microlitre + ng/ul @@ -5136,15 +4859,16 @@ + + "A unit of energy widely used in nutrition, equivalent to the amount of heat needed to cause one kilogram of water to rise in temperature by one degree Celsius." [Wikipedia:Wikipedia] + large calorie big calorie cal calorie food calorie kcal kilocalorie - "A unit of energy widely used in nutrition, equivalent to the amount of heat needed to cause one kilogram of water to rise in temperature by one degree Celsius." [Wikipedia:Wikipedia] - large calorie @@ -5153,9 +4877,9 @@ - micrograms per bottle "A unit of mass concentration defined as the number of micrograms of a substance per 250 ml Wheaton bottle." [UOB:LTS] micrograms per wheaton bottle + micrograms per bottle @@ -5174,16 +4898,10 @@ - - - - - - - - pA + "An electric current unit current which is equal to one trillionth of an ampere or 10^[-12] A." [UOB:LTS] picoampere + pA @@ -5202,16 +4920,10 @@ - - - - - - - - cGy + "An absorbed dose unit which is equal to 0.01 gray (Gy)" [NIST:NIST] centigray + cGy @@ -5230,16 +4942,10 @@ - - - - - - - - GeV + "A unit of energy that is equal to one thousand million electronvolts." [] gigaelectronvolt + GeV @@ -5248,9 +4954,9 @@ - GeV/nucleon "Derived unit which is equal to the total kinetic energy of an atomic nucleus in GeV divided by the number of nucleons in the nucleus" [] gigaelectronvolt per nucleon + GeV/nucleon @@ -5259,9 +4965,9 @@ - MeV/nucleon "Derived unit which is equal to the total kinetic energy of an atomic nucleus in MeV divided by the number of nucleons in the nucleus" [] megaelectronvolt per nucleon + MeV/nucleon @@ -5270,9 +4976,9 @@ - keV/micron "A derived unit equal to the energy deposited by ionizing radiation per micron of path length in matter" [] kiloelectronvolt per micron + keV/micron @@ -5280,10 +4986,11 @@ + - Gy/min "A derived absorbed dose unit which is equal to one gray absorbed per minute." [NIST:NIST] gray per minute + Gy/min @@ -5302,16 +5009,10 @@ - - - - - - - - cGy/min + "A derived absorbed dose unit which is equal to one centigray absorbed per minute." [NIST:NIST] centigray per minute + cGy/min @@ -5330,16 +5031,10 @@ - - - - - - - - mGy/day + "A derived absorbed dose unit which is equal to one milligray absorbed per minute." [NIST:NIST] milligray per minute + mGy/min @@ -5348,9 +5043,9 @@ - mGy/min "A derived absorbed dose unit which is equal to one milligray absorbed per day." [NIST:NIST] milligray per day + mGy/min @@ -5359,9 +5054,9 @@ - mGy/h "A derived absorbed dose unit which is equal to one milligray absorbed per hour." [NIST:NIST] milligray per hour + mGy/h @@ -5370,96 +5065,9 @@ - mGy/s "A derived absorbed dose unit which is equal to one milligray absorbed per second." [NIST:NIST] milligray per second - - - - - - - - - - - - - - - - - - - - - - - - - - kilometre - km - "A length unit which is equal to one thousand meters." [UOB:LKSR] - kilometer - - - - - - - - - - - - - - - - - - - - - - - - - - mg/dl - milligram per decilitre - "A mass unit density which is equal to mass of an object in milligrams divided by the volume in deciliters." [UOB:LKSR] - milligram per deciliter - - - - - - - - - - - - - - - - - - - - - - - - - - microgram per decilitre - ug/dl - "A mass unit density which is equal to mass of an object in micrograms divided by the volume in deciliters." [UOB:LKSR] - microgram per deciliter + mGy/s diff --git a/src/templates/RBO_classes.owl b/src/templates/RBO_classes.owl index d598e1e..a79044b 100644 --- a/src/templates/RBO_classes.owl +++ b/src/templates/RBO_classes.owl @@ -160,12 +160,6 @@ - - - - - - @@ -3349,7 +3343,7 @@ - + Nuclear decay in which an alpha particle is emitted. https://goldbook.iupac.org/terms/view/A00005 http://purl.obolibrary.org/obo/REX_0000017 @@ -3362,7 +3356,7 @@ - + Radioactive decay in which a beta particle is emitted or in which orbital electron capture occurs. http://goldbook.iupac.org/B00572.html http://purl.obolibrary.org/obo/REX_0000007