diff --git a/prereqs/Makefile b/prereqs/Makefile
index 304f1b007b..a3f0ef6d61 100644
--- a/prereqs/Makefile
+++ b/prereqs/Makefile
@@ -56,7 +56,7 @@ endif
 .NOTPARALLEL:
 
 # keep in alphabetical order, dependencies go below
-SUBDIRS	+= ambertools openmm pips PyQt Python
+SUBDIRS	+= ambertools pips PyQt Python
 
 
 # All needed subdirectories must be set by now.
diff --git a/prereqs/openmm/Makefile b/prereqs/openmm/Makefile
deleted file mode 100644
index 2d26534e0e..0000000000
--- a/prereqs/openmm/Makefile
+++ /dev/null
@@ -1,95 +0,0 @@
-PREREQ_MAKE = 1
-TOP	= ../..
-include $(TOP)/mk/config.make
-
-# Using OpenMM builds from https://anaconda.org/conda-forge/openmm/files
-VERSION = 8.0.0
-
-ifeq ($(OS),Darwin)
-PLATFORM = mac
-ifeq ($(MACOS_ARCH),arm64)
-DISTRIBUTION = openmm-8.0.0-mac-py311h68ae2cc_1_apple.tar.bz2
-else
-DISTRIBUTION = openmm-8.0.0-mac-py311hf4819f2_1_apple.tar.bz2
-endif
-# Tristan Croll provided these optional Mac Metal libraries used with OpenMM platform HIP
-MAC_METAL_PLUGIN = openmm-8.0.0-mac-metal.tar.bz2
-endif
-ifeq ($(OS),Linux)
-PLATFORM = linux
-# The Linux distribution comes from Tristan Croll
-# compiled Oct 31, 2022 with the same compiler as ChimeraX.
-# Using CUDA 11.2
-DISTRIBUTION = openmm-8.0.0-linux-py311_cuda112.tar.bz2
-endif
-ifeq ($(OS),Windows)
-PLATFORM = windows
-# Using CUDA 11.2
-DISTRIBUTION = openmm-8.0.0-win-py311h9957787_1.tar.bz2
-endif
-
-SOURCE = $(tmpdir)/OpenMM-$(VERSION)-$(PLATFORM)
-OPENMM_LIB_INSTALL = $(libdir)/openmm
-
-# Beware the Windows OpenMM has the Python code in a different location
-# than Mac and Linux, so one patch for OpenMM Python code won't find the
-# Python file on all 3 platforms.  Also the Windows Python has /r/n DOS
-# line endings and patches expecting /n line endings will fail.
-# Probably easiest to make a separate Windows patch.
-PATCHES	= $(wildcard OpenMM-$(OS)-*.patch)
-
-ifeq ($(OS),Windows)
-
-install: $(SOURCE)
-	cd $(SOURCE) ; \
-	  $(RSYNC) Lib/site-packages/openmm $(PYSITEDIR) ; \
-	  $(RSYNC) Library/lib/ --exclude site-packages $(OPENMM_LIB_INSTALL)
-
-else
-
-install: $(SOURCE)
-	cd $(SOURCE) ; \
-	  $(RSYNC) lib/python$(PYTHON_VERSION)/site-packages/openmm $(PYSITEDIR) ; \
-	  $(RSYNC) lib/ --exclude python$(PYTHON_VERSION) $(OPENMM_LIB_INSTALL)
-
-endif
-
-app-install: install
-	$(RSYNC) $(OPENMM_LIB_INSTALL)/* $(app_shlibdir)
-	$(RSYNC) $(PYSITEDIR)/openmm $(APP_PYSITEDIR)
-ifeq ($(OS),Windows)
-	cd $(app_shlibdir); mv OpenMM*.lib libs/
-endif
-
-$(SOURCE): $(DISTRIBUTION) $(MAC_METAL_PLUGIN)
-	-mkdir $(SOURCE)
-	tar xf $(DISTRIBUTION) -C $(SOURCE) --no-same-owner
-ifneq (,$(PATCHES))
-	for p in $(PATCHES); do \
-		(cd $(SOURCE) && patch -f -p0) < $$p ; \
-	done
-endif
-ifeq ($(OS),Windows)
-	cd $(SOURCE)/Lib ; \
-	  chmod a+x site-packages/openmm/*.pyd ; \
-	  chmod a+x site-packages/openmm/app/internal/*.pyd
-	cd $(SOURCE)/Library/lib ; \
-	  chmod a+x *dll *.lib plugins/*.dll plugins/*.lib
-endif
-ifeq ($(OS),Darwin)
-	tar xf $(MAC_METAL_PLUGIN) -C $(SOURCE)/lib/plugins
-endif
-
-$(DISTRIBUTION):
-	$(FETCH_PREREQ) $(PREREQS_ARCHIVE)/openmm/$(DISTRIBUTION)
-
-ifeq ($(OS),Darwin)
-$(MAC_METAL_PLUGIN):
-	$(FETCH_PREREQ) $(PREREQS_ARCHIVE)/openmm/$(MAC_METAL_PLUGIN)
-endif
-
-upload_new_version:
-	$(RSYNC) $(DISTRIBUTION) $(MAC_METAL_PLUGIN) $(PREREQS_UPLOAD)/openmm
-
-clean:
-	rm -rf $(SOURCE) $(DISTRIBUTION)
diff --git a/prereqs/openmm/OpenMM-Windows-plugins.patch b/prereqs/openmm/OpenMM-Windows-plugins.patch
deleted file mode 100644
index b34981bca5..0000000000
--- a/prereqs/openmm/OpenMM-Windows-plugins.patch
+++ /dev/null
@@ -1,24 +0,0 @@
-*** Lib/site-packages/openmm/__init__.py~	Wed May 10 16:58:02 2017
---- Lib/site-packages/openmm/__init__.py	Fri May 12 16:54:05 2017
-***************
-*** 24,30 ****
-  if os.getenv('OPENMM_PLUGIN_DIR') is None and os.path.isdir(version.openmm_library_path):
-      pluginLoadedLibNames = Platform.loadPluginsFromDirectory(os.path.join(version.openmm_library_path, 'plugins'))
-  else:
-!     pluginLoadedLibNames = Platform.loadPluginsFromDirectory(Platform.getDefaultPluginsDirectory())
-  
-  if sys.platform == 'win32':
-      os.environ['PATH'] = _path
---- 24,35 ----
-  if os.getenv('OPENMM_PLUGIN_DIR') is None and os.path.isdir(version.openmm_library_path):
-      pluginLoadedLibNames = Platform.loadPluginsFromDirectory(os.path.join(version.openmm_library_path, 'plugins'))
-  else:
-!      # Assume that openmm is installed in LIB/site-packages
-!      # and plugins are in LIB/plugins.  We are in
-!      # site-packages/openmm
-!      import os.path
-!      pluginDir = os.path.join(os.path.dirname(__file__), "..", "..", "..", "plugins")
-!      pluginLoadedLibNames = Platform.loadPluginsFromDirectory(pluginDir)
-  
-  if sys.platform == 'win32':
-      os.environ['PATH'] = _path
diff --git a/prereqs/openmm/README.txt b/prereqs/openmm/README.txt
deleted file mode 100644
index 46a41c20d1..0000000000
--- a/prereqs/openmm/README.txt
+++ /dev/null
@@ -1,41 +0,0 @@
-Build notes for OpenMM
-----------------------
-
-The 7.6 builds came from https://anaconda.org/conda-forge/openmm/files
-The linux build comes from Tristan Croll using the compiler used by ChimeraX.
-
-On Linux, we need OpenMM built with the same C++ compiler as the rest
-of ChimeraX so that ISOLDE can link to both ChimeraX and OpenMM libraries.
-At this time, that is CentOS 7 with devtoolset-9.  And it is
-devtoolset-9 so OpenMM can use newer C++ constructs.  See ticket #3756.
-In the openmm_build3.zip file with a build script and a singularity
-definition file that is used to create the .tar.gz file.  And that
-.tar.gz is placed on the chimerax web site for downloading.
-
-Old Build notes for OpenMM
---------------------------
-
-On Mac, Linux and Windows using the OpenMM builds from
-https://anaconda.org/omnia/openmm/files -- Version: 7.3.0 Label: main.
-
-The files are renamed from PLATFORM/openmm-VERSION-PYVER.tar.bz2 to
-	openemm-VERSION-PLATFORM-PYVER.tar.bz where PLATFORM changes
-	{ win-64: windows, osx-64: mac, linux-64: linux }
-
-Even Older Build notes for OpenMM
----------------------------------
-
-Formerly used the OpenMM 7.0.1 binary installers on Mac and Linux that
-include precompiled C++ libraries.  The SWIG Python wrapper is compiled by
-the install.sh script on our machine.  The C++ ABI used by our compiler
-must match the ABI used in the OpenMM C++ libraries.  Specifically on
-Linux the OpenMM libraries use a G++ version 4.9(?) compiler and G++
-5.x uses a different ABI.
-
-On Windows the OpenMM 7.0.1 binary installers only support Python 3.3 and
-3.4 and use Visual Studio 10 while we use Visual Studio Community 2015
-(not sure if these have compatible ABIs).  So instead we use the OpenMM
-conda install on Windows for Python 3.5 and copy the resulting binaries
-to a tar file to use in our builds.  These will need to be updated when
-we update to Python 3.6.
-
diff --git a/prereqs/openmm/openmm_linux_compile/README.txt b/prereqs/openmm/openmm_linux_compile/README.txt
deleted file mode 100644
index f89bb297c3..0000000000
--- a/prereqs/openmm/openmm_linux_compile/README.txt
+++ /dev/null
@@ -1,6 +0,0 @@
-These scripts provided by Tristan Croll to compile OpenMM using a CentOS 7 Docker Singularity image
-using a C++ compiler compatible with the ChimeraX distribution compiler.  This allows ISOLDE
-to link to both OpenMM and ChimeraX atomic_lib using the same C++ compiler.
-
-These scripts were provided in ChimeraX ticket #3756 and the compiled build was provided
-in ticket #4661.
diff --git a/prereqs/openmm/openmm_linux_compile/build.sh b/prereqs/openmm/openmm_linux_compile/build.sh
deleted file mode 100755
index 6fa6c78219..0000000000
--- a/prereqs/openmm/openmm_linux_compile/build.sh
+++ /dev/null
@@ -1,91 +0,0 @@
-#!/bin/bash
-set -e
-
-cd /tmp
-git clone https://github.com/openmm/openmm.git
-cd openmm
-git checkout 7.5_branch
-cd ..
-
-
-# CFLAGS
-export MINIMAL_CFLAGS="-g -O3"
-export CFLAGS="$MINIMAL_CFLAGS"
-export CXXFLAGS="$MINIMAL_CFLAGS"
-export LDFLAGS="$LDPATHFLAGS"
-
-INSTALL=`pwd`/install
-if [ -e $INSTALL ]; then
-    rm -rf $INSTALL
-fi
-
-CMAKE_FLAGS="-DCMAKE_INSTALL_PREFIX=$INSTALL"
-
-# Don't build tests
-CMAKE_FLAGS+=" -DBUILD_TESTING=OFF"
-
-# Ensure we build a release
-CMAKE_FLAGS+=" -DCMAKE_BUILD_TYPE=Release"
-
-# setting the rpath so that libOpenMMPME.so finds the right libfftw3
-#CMAKE_FLAGS+=" -DCMAKE_INSTALL_RPATH=.."
-# Use NVIDIA CUDA 
-CMAKE_FLAGS+=" -DCUDA_CUDART_LIBRARY=/usr/local/cuda/lib64/libcudart.so"
-CMAKE_FLAGS+=" -DCUDA_NVCC_EXECUTABLE=/usr/local/cuda/bin/nvcc"
-CMAKE_FLAGS+=" -DCUDA_SDK_ROOT_DIR=/usr/local/cuda/"
-CMAKE_FLAGS+=" -DCUDA_TOOLKIT_INCLUDE=/usr/local/cuda/include"
-CMAKE_FLAGS+=" -DCUDA_TOOLKIT_ROOT_DIR=/usr/local/cuda/"
-# So that FindCuda correctly finds libcuda.os
-CMAKE_FLAGS+=" -DCMAKE_LIBRARY_PATH=/usr/local/cuda/compat/"
-echo "CMAKE_FLAGS = $CMAKE_FLAGS"
-# Use AMD APP SDK 3.0
-#CMAKE_FLAGS+=" -DOPENCL_INCLUDE_DIR=/opt/AMDAPPSDK-3.0/include/"
-CMAKE_FLAGS+=" -DOPENCL_LIBRARY=/usr/local/cuda/lib64/libOpenCL.so"
-# Generate API docs
-CMAKE_FLAGS+=" -DOPENMM_GENERATE_API_DOCS=ON"
-# Set location for FFTW3
-CMAKE_FLAGS+=" -DFFTW_INCLUDES=/usr/include"
-CMAKE_FLAGS+=" -DFFTW_LIBRARY=/usr/lib64/libfftw3f.so"
-CMAKE_FLAGS+=" -DFFTW_THREADS_LIBRARY=/usr/lib64/libfftw3f_threads.so"
-# Necessary to find GL headers
-# CMAKE_FLAGS+=" -DCMAKE_CXX_FLAGS_RELEASE=-I/usr/include/nvidia/"
-
-if [ -e build ]; then
-  rm -rf build
-fi
-mkdir build
-cd build
-cmake3 ../openmm $CMAKE_FLAGS
-make -j12 all install
-
-export CFLAGS="$MINIMAL_CFLAGS"
-
-export CXXFLAGS="$MINIMAL_CFLAGS"
-export LDFLAGS="$LDPATHFLAGS"
-
-make -j20 PythonInstall
-
-make install
-
-export OPENMM_INCLUDE_PATH=$INSTALL/include
-export OPENMM_LIB_PATH=$INSTALL/lib
-PYTHON_VER=$(python3 -c 'import sys; print("%s.%s" % sys.version_info[0:2])')
-(cd python && python3 setup.py install --install-lib $INSTALL/lib/python${PYTHON_VER}/site-packages)
-find $INSTALL/lib -name \*.so -exec chrpath -d {} \;
-
-cd ..
-
-(cd install/lib && for so in plugins/*.so; do ln -s $so .; done && strip *.so)
-
-OPENMM_VER=$(python3 -c 'vtxt = open("build/python/simtk/openmm/version.py").read(); exec(vtxt); print(short_version)')
-PYTHON_VER_NODOT=$(python3 -c 'import sys; print("%s%s" % sys.version_info[0:2])')
-CUDA_VER=$(nvcc --version | awk '$4 == "release" {print $5}' | sed 's/[,.]//g')
-TAR_FILE=openmm-${OPENMM_VER}-linux-py${PYTHON_VER_NODOT}_cuda${CUDA_VER}_1.tar.bz2
-tar -jcf ${TAR_FILE} -C install .
-
-cp ${TAR_FILE} /host
-cd /tmp
-rm -fr openmm
-rm -fr build
-rm -fr $INSTALL
-
diff --git a/prereqs/openmm/openmm_linux_compile/centos-7-devtoolset-9-cuda.def b/prereqs/openmm/openmm_linux_compile/centos-7-devtoolset-9-cuda.def
deleted file mode 100644
index e1c2a53136..0000000000
--- a/prereqs/openmm/openmm_linux_compile/centos-7-devtoolset-9-cuda.def
+++ /dev/null
@@ -1,73 +0,0 @@
-Bootstrap: docker
-From: nvidia/cuda:11.2.1-devel-centos7
-
-%setup
-  # Runs on host. The path to the image is $SINGULARITY_ROOTFS
-
-%post
-  # Post setup, runs inside the image
-
-  #Host directory mount point
-  mkdir /host
-
-  #Add CUDA paths
-  echo "\n #Cuda paths \n" >> /environment
-  echo 'export CPATH="/usr/local/cuda/include:$CPATH"' >> /environment
-  echo 'export PATH="/usr/local/cuda/bin:$PATH"' >> /environment
-  echo 'export LD_LIBRARY_PATH="/usr/local/cuda/lib64:$LD_LIBRARY_PATH"' >> /environment
-  echo 'export CUDA_HOME="/usr/local/cuda"' >> /environment
-
-  # for Python source install - for some reason /usr/local/lib isn't on the library path by default
-  echo 'export LD_LIBRARY_PATH="/usr/local/lib:$LD_LIBRARY_PATH"' >> /environment
-  export LD_LIBRARY_PATH="/usr/local/lib:$LD_LIBRARY_PATH"
-  # install dependencies
-  
-  yum install -y centos-release-scl epel-release
-  yum groupinstall -y "Development Tools"
-  # OpenMM requires swig3 and cmake3. Remove the old versions installed by the group install
-  yum remove -y swig cmake
-  yum install -y \
-    devtoolset-9 \
-    swig3 \
-    cmake3 \
-    wget \
-    bzip2 bzip2-devel\
-    chrpath \
-    git \
-    doxygen \
-    fftw-devel
-#    rh-python39 rh-python39-python-devel rh-python39-python-pip \
-#    rh-python39-python-numpy rh-python39-python-Cython rh-python39-python-wheel \
-# Python 3.9 not yet available as rh package. Need to build from source
-
-#  scl enable rh-python39 "pip install sphinx sphinxcontrib-bibtex sphinxcontrib-lunrsearch sphinxcontrib-autodoc_doxygen lxml cmake"  
-  
-  yum -y install gcc openssl-devel libffi-devel
-
-  wget https://github.com/python/cpython/archive/refs/tags/v3.9.6.tar.gz
-  tar xvf v3.9.6.tar.gz
-  cd cpython-3.9.6
-  ./configure --enable-shared --with-ensurepip=install
-  make -j20
-  make install
-
-  cd ..
-  
-  pip3 install lxml numpy Cython
-    
-
-    
-  
-
-%runscript
-  #Executes when the "singularity run" command is used
-  #Useful when you want the container to run as an executable
-
- 
-  scl enable devtoolset-9 /host/build.sh
-
-
-%test
-  #Test script to verify that the image is built and running correctly
-
-
diff --git a/prereqs/openmm/openmm_linux_compile/run.sh b/prereqs/openmm/openmm_linux_compile/run.sh
deleted file mode 100755
index 0a98cda74e..0000000000
--- a/prereqs/openmm/openmm_linux_compile/run.sh
+++ /dev/null
@@ -1,2 +0,0 @@
-#!/bin/bash
-singularity run --fakeroot --bind .:/host centos-7-devtoolset-9-py39-cuda-openmm.sif
diff --git a/prereqs/pips/app_requirements.txt b/prereqs/pips/app_requirements.txt
index 49653b86fb..c4194aac42 100644
--- a/prereqs/pips/app_requirements.txt
+++ b/prereqs/pips/app_requirements.txt
@@ -33,6 +33,7 @@ netCDF4==1.6.5
 networkx==3.3
 numpy==1.26.4
 openvr==1.26.701
+openmm==8.2.0
 packaging==23.2
 # as per Tristan's request in ticket #3055
 ParmEd==4.2.2