diff --git a/.github/workflows/python-tests.yaml b/.github/workflows/python-tests.yaml
index ea0230832677..33af87e3b9f4 100644
--- a/.github/workflows/python-tests.yaml
+++ b/.github/workflows/python-tests.yaml
@@ -16,6 +16,7 @@ on:
       - requirements-dev.txt
       - setup.cfg
       - Dockerfile
+      - scripts/entrypoint.sh
   push:
     branches:
       - main
@@ -28,7 +29,7 @@ on:
       - requirements-dev.txt
       - setup.cfg
       - Dockerfile
-
+      - scripts/entrypoint.sh
 permissions:
   contents: read
   actions: write
diff --git a/flows/docker_deploy.py b/flows/docker_deploy.py
new file mode 100644
index 000000000000..8abd345ff6f9
--- /dev/null
+++ b/flows/docker_deploy.py
@@ -0,0 +1,105 @@
+import asyncio
+import subprocess
+import sys
+from pathlib import Path
+from textwrap import dedent
+
+from prefect import flow, get_client
+from prefect.deployments import run_deployment
+from prefect.docker.docker_image import DockerImage
+
+
+async def read_flow_run(flow_run_id: str):
+    """Read a flow run's state using the Prefect client."""
+    async with get_client() as client:
+        return await client.read_flow_run(flow_run_id)
+
+
+@flow
+def flow_that_needs_pandas() -> str:
+    """A flow that needs pandas."""
+    import pandas
+
+    df = pandas.DataFrame({"a": [1, 2, 3]})
+
+    assert isinstance(df, pandas.DataFrame)
+
+    return "we're done"
+
+
+def main():
+    """
+    Deploy and run a flow in a Docker container with runtime package installation using uv.
+    Demonstrates using EXTRA_PIP_PACKAGES to install dependencies at runtime.
+    """
+    try:
+        subprocess.check_call(
+            ["prefect", "work-pool", "create", "test-docker-pool", "-t", "docker"],
+            stdout=sys.stdout,
+            stderr=sys.stderr,
+        )
+
+        dockerfile = Path("docker-deploy.Dockerfile")
+
+        dockerfile.write_text(
+            dedent(
+                """
+                FROM prefecthq/prefect:3-latest
+                COPY flows/docker_deploy.py /opt/prefect/flows/docker_deploy.py
+                """
+            )
+        )
+
+        flow_that_needs_pandas.deploy(
+            name="docker-demo-deployment",
+            work_pool_name="test-docker-pool",
+            job_variables={
+                "env": {"EXTRA_PIP_PACKAGES": "pandas"},
+                "image": "prefect-integration-test-docker-deploy",
+            },
+            image=DockerImage(
+                name="prefect-integration-test-docker-deploy",
+                dockerfile=str(dockerfile),
+            ),
+            build=True,
+            push=False,
+        )
+
+        dockerfile.unlink()
+
+        flow_run = run_deployment(
+            "flow-that-needs-pandas/docker-demo-deployment",
+            timeout=0,
+        )
+
+        # Execute the flow run
+        subprocess.check_call(
+            [
+                "prefect",
+                "worker",
+                "start",
+                "--pool",
+                "test-docker-pool",
+                "--run-once",
+                "--install-policy",
+                "if-not-present",
+            ],
+            stdout=sys.stdout,
+            stderr=sys.stderr,
+        )
+
+        # Check the flow run state
+        flow_run = asyncio.run(read_flow_run(flow_run.id))
+        assert flow_run.state.is_completed(), flow_run.state
+
+    finally:
+        # Cleanup
+        subprocess.check_call(
+            ["prefect", "--no-prompt", "work-pool", "delete", "test-docker-pool"],
+            stdout=sys.stdout,
+            stderr=sys.stderr,
+        )
+
+
+if __name__ == "__main__":
+    main()
diff --git a/scripts/entrypoint.sh b/scripts/entrypoint.sh
index 1846618dbce1..3c780321ef1d 100755
--- a/scripts/entrypoint.sh
+++ b/scripts/entrypoint.sh
@@ -8,8 +8,8 @@ if [ -f ~/.bashrc ]; then
 fi
 
 if [ ! -z "$EXTRA_PIP_PACKAGES" ]; then
-  echo "+pip install $EXTRA_PIP_PACKAGES"
-  pip install $EXTRA_PIP_PACKAGES
+  echo "+uv pip install $EXTRA_PIP_PACKAGES"
+  uv pip install --system $EXTRA_PIP_PACKAGES
 fi
 
 if [ -z "$*" ]; then