diff --git a/app/src/organisms/Devices/ProtocolRun/ProtocolRunHeader.tsx b/app/src/organisms/Devices/ProtocolRun/ProtocolRunHeader.tsx
index 5c527bd053b..556d95f382d 100644
--- a/app/src/organisms/Devices/ProtocolRun/ProtocolRunHeader.tsx
+++ b/app/src/organisms/Devices/ProtocolRun/ProtocolRunHeader.tsx
@@ -46,6 +46,7 @@ import {
 } from '@opentrons/components'
 
 import { getRobotUpdateDisplayInfo } from '../../../redux/robot-update'
+import { getRobotSettings } from '../../../redux/robot-settings'
 import { ProtocolAnalysisErrorBanner } from './ProtocolAnalysisErrorBanner'
 import { ProtocolAnalysisErrorModal } from './ProtocolAnalysisErrorModal'
 import { Banner } from '../../../atoms/Banner'
@@ -83,6 +84,7 @@ import {
   useIsRobotViewable,
   useTrackProtocolRunEvent,
   useRobotAnalyticsData,
+  useIsOT3,
 } from '../hooks'
 import { formatTimestamp } from '../utils'
 import { RunTimer } from './RunTimer'
@@ -140,12 +142,25 @@ export function ProtocolRunHeader({
     runRecord?.data.errors?.[0] != null
       ? getHighestPriorityError(runRecord?.data?.errors)
       : null
+
+  const robotSettings = useSelector((state: State) =>
+    getRobotSettings(state, robotName)
+  )
+  const doorSafetySetting = robotSettings.find(
+    setting => setting.id === 'enableDoorSafetySwitch'
+  )
+  const isOT3 = useIsOT3(robotName)
   const { data: doorStatus } = useDoorQuery({
     refetchInterval: EQUIPMENT_POLL_MS,
   })
-  const isDoorOpen =
-    doorStatus?.data.status === 'open' &&
-    doorStatus?.data.doorRequiredClosedForProtocol
+  let isDoorOpen = false
+  if (isOT3) {
+    isDoorOpen = doorStatus?.data.status === 'open'
+  } else if (!isOT3 && Boolean(doorSafetySetting?.value)) {
+    isDoorOpen = doorStatus?.data.status === 'open'
+  } else {
+    isDoorOpen = false
+  }
 
   React.useEffect(() => {
     if (protocolData != null && !isRobotViewable) {
diff --git a/app/src/organisms/Devices/ProtocolRun/__tests__/ProtocolRunHeader.test.tsx b/app/src/organisms/Devices/ProtocolRun/__tests__/ProtocolRunHeader.test.tsx
index 31fa9c930ad..0e52d62c811 100644
--- a/app/src/organisms/Devices/ProtocolRun/__tests__/ProtocolRunHeader.test.tsx
+++ b/app/src/organisms/Devices/ProtocolRun/__tests__/ProtocolRunHeader.test.tsx
@@ -58,6 +58,7 @@ import {
 } from '../../../../redux/analytics'
 import { getRobotUpdateDisplayInfo } from '../../../../redux/robot-update'
 import { getIsHeaterShakerAttached } from '../../../../redux/config'
+import { getRobotSettings } from '../../../../redux/robot-settings'
 
 import {
   useProtocolDetailsForRun,
@@ -111,6 +112,7 @@ jest.mock('../../../../redux/analytics')
 jest.mock('../../../../redux/config')
 jest.mock('../RunFailedModal')
 jest.mock('../../../../redux/robot-update/selectors')
+jest.mock('../../../../redux/robot-settings/selectors')
 
 const mockGetIsHeaterShakerAttached = getIsHeaterShakerAttached as jest.MockedFunction<
   typeof getIsHeaterShakerAttached
@@ -192,6 +194,9 @@ const mockUseIsOT3 = useIsOT3 as jest.MockedFunction<typeof useIsOT3>
 const mockUseDoorQuery = useDoorQuery as jest.MockedFunction<
   typeof useDoorQuery
 >
+const mockGetRobotSettings = getRobotSettings as jest.MockedFunction<
+  typeof getRobotSettings
+>
 
 const ROBOT_NAME = 'otie'
 const RUN_ID = '95e67900-bc9f-4fbf-92c6-cc4d7226a51b'
@@ -199,6 +204,13 @@ const CREATED_AT = '03/03/2022 19:08:49'
 const STARTED_AT = '2022-03-03T19:09:40.620530+00:00'
 const COMPLETED_AT = '2022-03-03T19:39:53.620530+00:00'
 const PROTOCOL_NAME = 'A Protocol for Otie'
+const mockSettings = {
+  id: 'enableDoorSafetySwitch',
+  title: 'Enable Door Safety Switch',
+  description: '',
+  value: true,
+  restart_required: false,
+}
 
 const simpleV6Protocol = (_uncastedSimpleV6Protocol as unknown) as CompletedProtocolAnalysis
 
@@ -351,10 +363,11 @@ describe('ProtocolRunHeader', () => {
     when(mockUseRunCalibrationStatus)
       .calledWith(ROBOT_NAME, RUN_ID)
       .mockReturnValue({ complete: true })
-    mockUseIsOT3.mockReturnValue(true)
+    when(mockUseIsOT3).calledWith(ROBOT_NAME).mockReturnValue(true)
     mockRunFailedModal.mockReturnValue(<div>mock RunFailedModal</div>)
     mockUseEstopQuery.mockReturnValue({ data: mockEstopStatus } as any)
     mockUseDoorQuery.mockReturnValue({ data: mockDoorStatus } as any)
+    mockGetRobotSettings.mockReturnValue([mockSettings])
   })
 
   afterEach(() => {
@@ -849,7 +862,17 @@ describe('ProtocolRunHeader', () => {
     getByLabelText('ot-spinner')
   })
 
-  it('renders banner when the robot door is open', () => {
+  it('renders door close banner when the robot door is open', () => {
+    const mockOpenDoorStatus = {
+      data: { status: 'open', doorRequiredClosedForProtocol: true },
+    }
+    mockUseDoorQuery.mockReturnValue({ data: mockOpenDoorStatus } as any)
+    const [{ getByText }] = render()
+    getByText('Close the robot door before starting the run.')
+  })
+
+  it('should render door close banner when door is open and enabled safety door switch is on - OT-2', () => {
+    when(mockUseIsOT3).calledWith(ROBOT_NAME).mockReturnValue(false)
     const mockOpenDoorStatus = {
       data: { status: 'open', doorRequiredClosedForProtocol: true },
     }
@@ -857,4 +880,18 @@ describe('ProtocolRunHeader', () => {
     const [{ getByText }] = render()
     getByText('Close the robot door before starting the run.')
   })
+
+  it('should not render door close banner when door is open and enabled safety door switch is off - OT-2', () => {
+    when(mockUseIsOT3).calledWith(ROBOT_NAME).mockReturnValue(false)
+    const mockOffSettings = { ...mockSettings, value: false }
+    mockGetRobotSettings.mockReturnValue([mockOffSettings])
+    const mockOpenDoorStatus = {
+      data: { status: 'open', doorRequiredClosedForProtocol: true },
+    }
+    mockUseDoorQuery.mockReturnValue({ data: mockOpenDoorStatus } as any)
+    const [{ queryByText }] = render()
+    expect(
+      queryByText('Close the robot door before starting the run.')
+    ).not.toBeInTheDocument()
+  })
 })