diff --git a/hardware/opentrons_hardware/scripts/provision_hepauv.py b/hardware/opentrons_hardware/scripts/provision_hepauv.py
new file mode 100644
index 00000000000..673f8890f86
--- /dev/null
+++ b/hardware/opentrons_hardware/scripts/provision_hepauv.py
@@ -0,0 +1,211 @@
+#!/usr/bin/env python3
+"""Provisions hepauv EEPROMs.
+
+This can be used either on a production line or locally.
+
+A log of what has been flashed to the hepauv
+/var/log/provision_hepauv.log
+"""
+
+import re
+import asyncio
+import logging
+import logging.config
+import argparse
+import struct
+from typing import Any, Tuple, Dict, Optional
+
+from opentrons_hardware.instruments.serial_utils import ensure_serial_length
+from opentrons_hardware.drivers.can_bus import build, CanMessenger
+from opentrons_hardware.firmware_bindings.arbitration_id import ArbitrationId
+from opentrons_hardware.firmware_bindings.utils import UInt16Field
+from opentrons_hardware.firmware_bindings.messages.messages import MessageDefinition
+from opentrons_hardware.firmware_bindings.messages import (
+    message_definitions as md,
+    payloads,
+    fields,
+)
+from opentrons_hardware.firmware_bindings.constants import NodeId, MessageId
+from opentrons_hardware.scripts.can_args import add_can_args, build_settings
+
+
+log = logging.getLogger(__name__)
+
+
+INFO_REGEX_STRING = (
+    "^"  # start of string
+    "HUV"  # The characters HUV
+    r"(?P<model>\d{2})"  # "model" group contains exactly 2 digits
+    r"(?P<code>[\w\d]{0,12})"  # "code" group contains 0 to 12 inclusive alphanumeric characters
+    "$"  # end of string
+)
+
+SERIAL_RE = re.compile(INFO_REGEX_STRING)
+
+
+async def get_serial(prompt: str) -> Tuple[int, bytes]:
+    """Get a serial number that is correct and parseable."""
+    while True:
+        serial = input(prompt).strip()
+
+        # Match the string
+        matches = SERIAL_RE.match(serial.strip())
+        if matches:
+            model = int(matches.group("model"))
+            data = ensure_serial_length(matches.group("code").encode("ascii"))
+            if not serial or "y" not in input(
+                f"read serial '{serial}', write to hepauv? (y/n): "
+            ):
+                continue
+            log.info(f"parsed model {model} datecode {data!r} from {serial}")
+            return model, data
+        raise RuntimeError(f"Invalid serial number: {serial}")
+
+
+async def update_serial_and_confirm(
+    messenger: CanMessenger,
+    model: int,
+    data: bytes,
+    attempts: int = 3,
+) -> bool:
+    """Update and verify the update of serial data."""
+    hepauv_info: Optional[md.HepaUVInfoResponse] = None
+    event = asyncio.Event()
+
+    def _listener(message: MessageDefinition, _: ArbitrationId) -> None:
+        nonlocal hepauv_info
+        if isinstance(message, md.HepaUVInfoResponse):
+            hepauv_info = message
+            event.set()
+
+    def _filter(arb_id: ArbitrationId) -> bool:
+        return (NodeId(arb_id.parts.originating_node_id) == NodeId.hepa_uv) and (
+            MessageId(arb_id.parts.message_id) == MessageId.hepauv_info_response
+        )
+
+    messenger.add_listener(_listener, _filter)
+
+    serial_bytes = struct.pack(">H16s", model, ensure_serial_length(data))
+    set_message = md.SetSerialNumber(
+        payload=payloads.SerialNumberPayload(serial=fields.SerialField(serial_bytes))
+    )
+    for attempt in range(attempts):
+        log.debug(
+            f"beginning set and confirm attempt {attempt} with bytes {serial_bytes!r}"
+        )
+        await messenger.send(NodeId.hepa_uv, set_message)
+        log.debug(f"Sent set-serial: {set_message}")
+
+        # wait some time before confirming
+        await asyncio.sleep(1)
+
+        # confirm that we set the proper serial number
+        log.info("Confirming serial number")
+        await messenger.send(node_id=NodeId.hepa_uv, message=md.InstrumentInfoRequest())
+        try:
+            await asyncio.wait_for(event.wait(), 1.0)
+            if (
+                hepauv_info
+                and hepauv_info.payload.model == UInt16Field(model)
+                and hepauv_info.payload.serial == fields.SerialField(data)
+            ):
+                log.info(f"serial confirmed on attempt {attempt}")
+                messenger.remove_listener(_listener)
+                return True
+        except asyncio.TimeoutError:
+            log.warning("Instrument info request timed out")
+
+    messenger.remove_listener(_listener)
+    log.error(f"Could not get HepaInfoResponse after {attempts} retries.")
+    return False
+
+
+async def _main(args: argparse.Namespace) -> None:
+    """Script entrypoint."""
+    async with build.driver(build_settings(args)) as driver, CanMessenger(
+        driver
+    ) as messenger:
+        while True:
+            try:
+                model, data = await get_serial("Enter serial for hepauv: ")
+                success = await update_serial_and_confirm(messenger, model, data)
+            except KeyboardInterrupt:
+                log.warning("Keyboard Interrupt!")
+                break
+            except RuntimeError as e:
+                log.error(e)
+                continue
+
+            # print result
+            log.info(f"SUCCESS,{model},{data!r}") if success else log.error(
+                f"FAILURE,{model},{data!r}"
+            )
+
+            # breakout if we only want to program once
+            if args.once:
+                break
+
+
+def log_config(log_level: int) -> Dict[str, Any]:
+    """Configure logging."""
+    return {
+        "version": 1,
+        "disable_existing_loggers": False,
+        "formatters": {
+            "basic": {"format": "%(asctime)s %(name)s %(levelname)s %(message)s"}
+        },
+        "handlers": {
+            "stream_handler": {
+                "class": "logging.StreamHandler",
+                "formatter": "basic",
+                "level": log_level,
+            },
+            "file_handler": {
+                "class": "logging.handlers.RotatingFileHandler",
+                "formatter": "basic",
+                "filename": "/var/log/provision_hepauv.log",
+                "maxBytes": 5000000,
+                "level": log_level,
+                "backupCount": 3,
+            },
+        },
+        "loggers": {
+            "": {
+                "handlers": ["stream_handler"]
+                if log_level > logging.INFO
+                else ["stream_handler", "file_handler"],
+                "level": log_level,
+            },
+        },
+    }
+
+
+if __name__ == "__main__":
+    parser = argparse.ArgumentParser(description=__doc__)
+    parser.add_argument(
+        "-l",
+        "--log-level",
+        help=(
+            "Developer logging level. At DEBUG or below, logs are written "
+            "to console; at INFO or above, logs are only written to "
+            "provision_hepauv.log"
+        ),
+        type=str,
+        choices=["DEBUG", "INFO", "WARNING", "ERROR"],
+        default="INFO",
+    )
+    parser.add_argument(
+        "--once",
+        action="store_true",
+        help="Run just once and quit instead of staying in a loop",
+    )
+    add_can_args(parser)
+
+    args = parser.parse_args()
+    logging.config.dictConfig(log_config(getattr(logging, args.log_level)))
+    try:
+        asyncio.run(_main(args))
+    except Exception as e:
+        log.exception(f"Unexpected exception: {e}")
+    finally:
+        log.info("Exiting...")