diff --git a/pkgs/development/python-modules/h5py/default.nix b/pkgs/development/python-modules/h5py/default.nix
index 47873be56b622..cd60ecd9100a4 100644
--- a/pkgs/development/python-modules/h5py/default.nix
+++ b/pkgs/development/python-modules/h5py/default.nix
@@ -35,11 +35,13 @@ buildPythonPackage rec {
 
   pythonRelaxDeps = [ "mpi4py" ];
 
-  # avoid strict pinning of numpy, can't be replaced with pythonRelaxDepsHook,
-  # see: https://github.com/NixOS/nixpkgs/issues/327941
+  # avoid strict pinning of numpy and mpi4py, can't be replaced with
+  # pythonRelaxDepsHook, see: https://github.com/NixOS/nixpkgs/issues/327941
   postPatch = ''
     substituteInPlace pyproject.toml \
       --replace-fail "numpy >=2.0.0, <3" "numpy"
+    substituteInPlace setup.py \
+      --replace-fail "mpi4py ==3.1.6" "mpi4py"
   '';
 
   env = {
diff --git a/pkgs/development/python-modules/h5py/mpi4py-requirement.patch b/pkgs/development/python-modules/h5py/mpi4py-requirement.patch
deleted file mode 100644
index b32e804ebe5ff..0000000000000
--- a/pkgs/development/python-modules/h5py/mpi4py-requirement.patch
+++ /dev/null
@@ -1,13 +0,0 @@
-diff --git a/setup.py b/setup.py
-index b1463422..7f0c7b10 100755
---- a/setup.py
-+++ b/setup.py
-@@ -47,7 +47,7 @@ if setup_configure.mpi_enabled():
-     # incompatible with newer setuptools.
-     RUN_REQUIRES.append('mpi4py >=3.1.1')
-     SETUP_REQUIRES.append("mpi4py ==3.1.1; python_version<'3.11'")
--    SETUP_REQUIRES.append("mpi4py ==3.1.4; python_version>='3.11'")
-+    SETUP_REQUIRES.append("mpi4py >=3.1.4; python_version>='3.11'")
- 
- # Set the environment variable H5PY_SETUP_REQUIRES=0 if we need to skip
- # setup_requires for any reason.