Create recurrent mutations track

[cmdcolin]

We really like the ability to create mutation tracks

If it could show, the recurrence across all the GDC, that would be great

If it could also show recurrence specifically across the samples in your query, that would also be good

In our call we looked at how the mutations tab had for example 560/10000 patients in the GDC portal all shared the BRAF mutation

I think another use case would show that after filtering on brain cancer patients, that for example 50/400 brain cancer patients have some mutation

[cmdcolin]

We could do this by coloring features that are more recurrent or just filtering for recurrent mutations

[agduncan94]

Looking at the GDC exploration portal network request (see SsmsTable request), there is a score attribute for a mutation that is equal to the number of occurrences of a mutation in a cohort.

This score field is currently being used by the plugin, such that it fetches mutations, sorted by the score (highest score first).

This request also shows how to count the filtered and total number of occurrences, along with the total number of cases in the query and total number of cases across the GDC. These can then be used to highlight by mutation recurrence across GDC or cohort, either as a raw score or percentage. We can also show these values within a feature detail so that users can understand the importance of a mutation.