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Add support for ME models #664

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stelmo opened this issue Sep 2, 2022 · 4 comments
Closed

Add support for ME models #664

stelmo opened this issue Sep 2, 2022 · 4 comments
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@stelmo
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stelmo commented Sep 2, 2022

Currently COBREXA only supports M (metabolic) models. Increasingly people are building ME (metabolic and expression) models. These are much more complicated since they include ribosomes etc., and are no longer LPs, but are much more expressive and capture substantially more physiology than basic M models. We should make a model type that can handle them. Also, StandardModel should be extended to be able to cope with whatever extra info is required to build them (#655 is step 1 in this direction). See here for the only other attempt at this:

https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006302

@stelmo stelmo added feature New feature/functionality ❌ breaking Merging requires a major version bump labels Sep 2, 2022
@stelmo stelmo added this to the Wishlist milestone Sep 2, 2022
@exaexa
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exaexa commented Sep 2, 2022

can we make a list of the stuff that this will break?

Currently I'm only aware about the extended GRRs (where you need stoichiometry for each gene building piece).

@exaexa exaexa removed the ❌ breaking Merging requires a major version bump label Sep 28, 2022
@stelmo
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stelmo commented Oct 25, 2022

Probably want to go with RBA models instead

@stelmo
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stelmo commented Jan 9, 2023

#717 is a start along with this process. However, full RBA might have to wait until later since I doubt it will be done within the next 2 months (the window for 2.0)

@exaexa
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exaexa commented May 14, 2024

Made trivial in cobrexa 2, closing

@exaexa exaexa closed this as completed May 14, 2024
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