diff --git a/.github/workflows/build-test-package.yml b/.github/workflows/build-test-package.yml
index b9c352d..25de1e7 100644
--- a/.github/workflows/build-test-package.yml
+++ b/.github/workflows/build-test-package.yml
@@ -2,32 +2,33 @@ name: Build, test, package
 
 on: [push,pull_request]
 
+env:
+  itk-git-tag: "801370c025c7d296783481779a41c6d559c992c5"
+  itk-wheel-tag: "v5.3rc04"
+
 jobs:
   build-test-cxx:
     runs-on: ${{ matrix.os }}
     strategy:
       max-parallel: 3
       matrix:
-        os: [ubuntu-18.04, windows-2019, macos-10.15]
+        os: [ubuntu-20.04, windows-2019, macos-10.15]
         include:
-          - os: ubuntu-18.04
+          - os: ubuntu-20.04
             c-compiler: "gcc"
             cxx-compiler: "g++"
-            itk-git-tag: "a89145bccda6a36f42cfdd45d3a6b27234ff54fe"
             cmake-build-type: "MinSizeRel"
           - os: windows-2019
             c-compiler: "cl.exe"
             cxx-compiler: "cl.exe"
-            itk-git-tag: "a89145bccda6a36f42cfdd45d3a6b27234ff54fe"
             cmake-build-type: "Release"
           - os: macos-10.15
             c-compiler: "clang"
             cxx-compiler: "clang++"
-            itk-git-tag: "a89145bccda6a36f42cfdd45d3a6b27234ff54fe"
             cmake-build-type: "MinSizeRel"
 
     steps:
-    - uses: actions/checkout@v1
+    - uses: actions/checkout@v2
 
     - name: Set up Python 3.8
       uses: actions/setup-python@v2
@@ -47,7 +48,7 @@ jobs:
         cd ..
         git clone https://github.com/InsightSoftwareConsortium/ITK.git
         cd ITK
-        git checkout ${{ matrix.itk-git-tag }}
+        git checkout ${{ env.itk-git-tag }}
 
     - name: Build ITK
       if: matrix.os != 'windows-2019'
@@ -134,9 +135,7 @@ jobs:
     strategy:
       max-parallel: 2
       matrix:
-        python-version: [36, 37, 38, 39]
-        include:
-          - itk-python-git-tag: "v5.2.1.post1"
+        python-version: [37, 38, 39, 310]
 
     steps:
     - uses: actions/checkout@v2
@@ -157,7 +156,7 @@ jobs:
 
     - name: 'Build 🐍 Python 📦 package'
       run: |
-        export ITK_PACKAGE_VERSION=${{ matrix.itk-python-git-tag }}
+        export ITK_PACKAGE_VERSION=${{ env.itk-wheel-tag }}
         ./dockcross-manylinux-download-cache-and-build-module-wheels.sh cp${{ matrix.python-version }}
 
     - name: Publish Python package as GitHub Artifact
@@ -170,9 +169,6 @@ jobs:
     runs-on: macos-10.15
     strategy:
       max-parallel: 2
-      matrix:
-        include:
-          - itk-python-git-tag: "v5.2.1.post1"
 
     steps:
     - uses: actions/checkout@v2
@@ -191,7 +187,7 @@ jobs:
 
     - name: 'Build 🐍 Python 📦 package'
       run: |
-        export ITK_PACKAGE_VERSION=${{ matrix.itk-python-git-tag }}
+        export ITK_PACKAGE_VERSION=${{ env.itk-wheel-tag }}
         export MACOSX_DEPLOYMENT_TARGET=10.9
         ./macpython-download-cache-and-build-module-wheels.sh
 
@@ -206,9 +202,7 @@ jobs:
     strategy:
       max-parallel: 2
       matrix:
-        python-version-minor: [6, 7, 8, 9]
-        include:
-          - itk-python-git-tag: "v5.2.1.post1"
+        python-version-minor: [7, 8, 9, 10]
 
     steps:
     - name: Get specific version of CMake, Ninja
@@ -228,8 +222,8 @@ jobs:
       shell: bash
       run: |
         mv im ../../
-        cd ../../
-        curl -L "https://github.com/InsightSoftwareConsortium/ITKPythonBuilds/releases/download/${{ matrix.itk-python-git-tag }}/ITKPythonBuilds-windows.zip" -o "ITKPythonBuilds-windows.zip"
+        cd ../../im
+        curl -L "https://github.com/InsightSoftwareConsortium/ITKPythonBuilds/releases/download/${{ env.itk-wheel-tag }}/ITKPythonBuilds-windows.zip" -o "ITKPythonBuilds-windows.zip"
         7z x ITKPythonBuilds-windows.zip -o/c/P -aoa -r
         curl -L "https://data.kitware.com/api/v1/file/5c0ad59d8d777f2179dd3e9c/download" -o "doxygen-1.8.11.windows.bin.zip"
         7z x doxygen-1.8.11.windows.bin.zip -o/c/P/doxygen -aoa -r
@@ -241,7 +235,7 @@ jobs:
       run: |
         cd ../../im
         call "C:\Program Files (x86)\Microsoft Visual Studio\2019\Enterprise\VC\Auxiliary\Build\vcvars64.bat"
-        set PATH="C:\P\grep;%PATH%"
+        set PATH=C:\P\grep;%PATH%
         set CC=cl.exe
         set CXX=cl.exe
         C:\Python3${{ matrix.python-version-minor }}-x64\python.exe C:\P\IPP\scripts\windows_build_module_wheels.py --py-envs "3${{ matrix.python-version-minor }}-x64" --no-cleanup
@@ -257,7 +251,7 @@ jobs:
       - build-linux-python-packages
       - build-macos-python-packages
       - build-windows-python-packages
-    runs-on: ubuntu-18.04
+    runs-on: ubuntu-20.04
 
     steps:
     - name: Download Python Packages
diff --git a/setup.py b/setup.py
index 344be6b..63777ff 100644
--- a/setup.py
+++ b/setup.py
@@ -53,6 +53,6 @@
     keywords='ITK Strain Tensor Displacement Field',
     url=r'https://github.com/InsightSoftwareConsortium/ITKStrain',
     install_requires=[
-        r'itk>=5.2.1.post1'
+        r'itk>=5.3rc4'
     ]
     )