MTAG meta-analysis may result in low heritability

[liangcheng-hrbmu]

My dear,
I would like to know whether using MTAG for meta-analysis will result in too low heritability (Observed h2) of traits calculated by LDSC or LDAK.

[paturley]

We didn't test this formally in the MTAG paper, so a don't have a very rigorous answer for you. I remember seeing a MTAG on IQ (Hill et al maybe?) where they looked a little into this, but I don't recall the exact reference.

…

On Thu, Nov 30, 2023, 8:54 PM liang cheng ***@***.***> wrote: My dear, I would like to know whether using MTAG for meta-analysis will result in too low heritability (Observed h2) of traits calculated by LDSC or LDAK. — Reply to this email directly, view it on GitHub <#195>, or unsubscribe <https://github.com/notifications/unsubscribe-auth/AFBUB5NWEYC2HOMJAGOYVQLYHE2EDAVCNFSM6AAAAABACDVDDCVHI2DSMVQWIX3LMV43ASLTON2WKOZSGAYTSOBYG43DMMY> . You are receiving this because you are subscribed to this thread.Message ID: ***@***.***>