diff --git a/src/main/java/com/intel/gkl/compression/IntelDeflater.java b/src/main/java/com/intel/gkl/compression/IntelDeflater.java
index ed06a963..ec29e6f2 100644
--- a/src/main/java/com/intel/gkl/compression/IntelDeflater.java
+++ b/src/main/java/com/intel/gkl/compression/IntelDeflater.java
@@ -139,6 +139,7 @@ public void setInput(byte[] b, int off, int len) throws NullPointerException {
         if(len <= 0) {
             throw new NullPointerException("Input buffer length is zero.");
         }
+
         inputBuffer = b;
         inputBufferLength = len;
     }
diff --git a/src/main/java/com/intel/gkl/compression/IntelInflater.java b/src/main/java/com/intel/gkl/compression/IntelInflater.java
index d3c3b284..f19c3929 100644
--- a/src/main/java/com/intel/gkl/compression/IntelInflater.java
+++ b/src/main/java/com/intel/gkl/compression/IntelInflater.java
@@ -69,12 +69,13 @@ public synchronized boolean load(File tempDir) {
     private long lz_stream;
     private byte[] inputBuffer;
     private int inputBufferLength;
+    private int inputBufferOffset;
     private boolean finished;
     private boolean nowrap;
 
     private static native void initNative();
     private native void resetNative(boolean nowrap);
-    private native int inflateNative( byte[] b, int len);
+    private native int inflateNative( byte[] b, int off, int len);
     private native void endNative();
 
     /**
@@ -122,6 +123,7 @@ public void setInput(byte[] b, int off, int len) throws NullPointerException {
             throw new NullPointerException("Input buffer length is zero.");
         }
         inputBuffer = b;
+        inputBufferOffset = off;
         inputBufferLength = len;
     }
 
@@ -139,7 +141,7 @@ public void setInput(byte[] b, int off, int len) throws NullPointerException {
      */
     @Override
     public int inflate (byte[] b, int off, int len ) {
-        return inflateNative(b, len);
+        return inflateNative(b, off, len);
     }
 
     /**
@@ -150,7 +152,7 @@ public int inflate (byte[] b, int off, int len ) {
      */
     @Override
     public int inflate (byte[] b ) {
-        return inflateNative( b, 0);
+        return inflateNative( b, 0, 0);
     }
 
     /**
diff --git a/src/main/native/compression/IntelInflater.cc b/src/main/native/compression/IntelInflater.cc
index bbf005b1..fba9b168 100644
--- a/src/main/native/compression/IntelInflater.cc
+++ b/src/main/native/compression/IntelInflater.cc
@@ -51,6 +51,7 @@ static jfieldID FID_inf_lz_stream;
 static jfieldID FID_inf_inputBuffer;
 static jfieldID FID_inf_inputBufferLength;
 static jfieldID FID_inf_finished;
+static jfieldID FID_inf_inputBufferOffset;
 
 
 
@@ -63,6 +64,7 @@ JNIEXPORT void JNICALL Java_com_intel_gkl_compression_IntelInflater_initNative
   FID_inf_inputBuffer = env->GetFieldID(cls, "inputBuffer", "[B");
   FID_inf_inputBufferLength = env->GetFieldID(cls, "inputBufferLength", "I");
   FID_inf_finished = env->GetFieldID(cls, "finished", "Z");
+  FID_inf_inputBufferOffset = env->GetFieldID(cls, "inputBufferOffset", "I");
 
 }
 
@@ -82,8 +84,6 @@ JNIEXPORT void JNICALL Java_com_intel_gkl_compression_IntelInflater_resetNative
       env->SetLongField(obj, FID_inf_lz_stream, (jlong)lz_stream);
 
 
-
-      
       isal_inflate_init(lz_stream);
 
       lz_stream->avail_in = 0;
@@ -97,7 +97,7 @@ JNIEXPORT void JNICALL Java_com_intel_gkl_compression_IntelInflater_resetNative
 
 
 JNIEXPORT jint JNICALL Java_com_intel_gkl_compression_IntelInflater_inflateNative
-(JNIEnv * env, jobject obj, jbyteArray outputBuffer, jint outputBufferLength)
+(JNIEnv * env, jobject obj, jbyteArray outputBuffer, jint outputBufferOffset, jint outputBufferLength)
 {
 
 
@@ -106,13 +106,16 @@ JNIEXPORT jint JNICALL Java_com_intel_gkl_compression_IntelInflater_inflateNativ
 
     jbyteArray inputBuffer = (jbyteArray)env->GetObjectField(obj, FID_inf_inputBuffer);
       jint inputBufferLength = env->GetIntField(obj, FID_inf_inputBufferLength);
+      jint inputBufferOffset = env->GetIntField(obj, FID_inf_inputBufferOffset);
+
 
         jbyte* next_in = (jbyte*)env->GetPrimitiveArrayCritical(inputBuffer, 0);
         jbyte* next_out = (jbyte*)env->GetPrimitiveArrayCritical(outputBuffer, 0);
 
-        lz_stream->next_in = (Bytef *) next_in;
+
+        lz_stream->next_in = (Bytef *) (next_in + inputBufferOffset);
         lz_stream->avail_in = (uInt) inputBufferLength;
-        lz_stream->next_out = (Bytef *) next_out;
+        lz_stream->next_out = (Bytef *) (next_out + outputBufferOffset);
         lz_stream->avail_out = (uInt) outputBufferLength;
 
         int bytes_in = inputBufferLength;
diff --git a/src/main/native/compression/IntelInflater.h b/src/main/native/compression/IntelInflater.h
index cfa2c6ae..9aa2e677 100644
--- a/src/main/native/compression/IntelInflater.h
+++ b/src/main/native/compression/IntelInflater.h
@@ -29,7 +29,7 @@ JNIEXPORT void JNICALL Java_com_intel_gkl_compression_IntelInflater_resetNative
  * Signature: ([BI)I
  */
 JNIEXPORT jint JNICALL Java_com_intel_gkl_compression_IntelInflater_inflateNative
-  (JNIEnv *, jobject, jbyteArray, jint);
+  (JNIEnv *, jobject, jbyteArray, jint, jint);
 
 /*
  * Class:     com_intel_gkl_compression_IntelInflater