Before running HandyBrowser the first time, make sure you have Docker installed and running [Note: you don't need a Docker account, simply just the Docker service so we can install the dependencies for your Handshake node]:
Windows Docker Download - https://docs.docker.com/docker-for-windows/release-notes/
After installing Docker, run the Docker application first, then simply double click HandyBrowser.exe to begin the install. The setup will take just a few minutes, and it only needs to do this once, so please be patient.