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gtpo.owl
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@prefix : <http://www.guidetopharmacology.org/ns/gtpo/> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xml: <http://www.w3.org/XML/1998/namespace> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix gtpo: <http://www.guidetopharmacology.org/ns/gtpo/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix vann: <http://purl.org/vocab/vann/> .
@base <http://www.guidetopharmacology.org/ns/gtpo> .
<http://www.guidetopharmacology.org/ns/gtpo> rdf:type owl:Ontology ;
owl:versionInfo 0.2 ;
dct:creator "Alasdair J G Gray" ;
dct:license <http://creativecommons.org/licenses/by/4.0/> ;
dct:description "The Guide to Pharmacoloty Ontoloty (GTPO) is used to define entities, which appear in the Guide to Pharmacology RDF representation"^^xsd:string ;
dct:creator "Liam Bruce" ,
<http://orcid.org/0000-0002-5711-4872> ;
rdfs:seeAlso <http://www.guidetopharmacology.org/> ;
dct:title "The Guide to Pharmacology Ontology" ;
vann:preferredNamespacePrefix "gtpo" .
#################################################################
# Object Properties
#################################################################
### http://www.guidetopharmacology.org/ns/gtpo/InChIID
gtpo:InChIID rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Ligand ;
rdfs:range xsd:string .
### http://www.guidetopharmacology.org/ns/gtpo/InChIKEY
gtpo:InChIKEY rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Ligand ;
rdfs:range xsd:string .
### http://www.guidetopharmacology.org/ns/gtpo/approved
gtpo:approved rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Ligand ;
rdfs:range xsd:string .
### http://www.guidetopharmacology.org/ns/gtpo/canonicalSMILES
gtpo:canonicalSMILES rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Ligand ;
rdfs:range xsd:string .
### http://www.guidetopharmacology.org/ns/gtpo/chemicalClassName
gtpo:chemicalClassName rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:ChemicalClass ;
rdfs:range xsd:string .
### http://www.guidetopharmacology.org/ns/gtpo/comment
gtpo:comment rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Ligand ;
rdfs:range xsd:string .
### http://www.guidetopharmacology.org/ns/gtpo/hasAction
gtpo:hasAction rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Target ;
rdfs:range gtpo:Action ;
rdfs:comment "Action of an interaction" .
### http://www.guidetopharmacology.org/ns/gtpo/hasAffinity
gtpo:hasAffinity rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Interaction ;
rdfs:comment "Reference to blank node describing interaction affinity values and units" .
### http://www.guidetopharmacology.org/ns/gtpo/hasAnnotationStatus
gtpo:hasAnnotationStatus rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Target ;
rdfs:range gtpo:AnnotationStatus ;
rdfs:comment "Annotation status of a given target" .
### http://www.guidetopharmacology.org/ns/gtpo/hasChemicalClass
gtpo:hasChemicalClass rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Ligand ;
rdfs:range gtpo:ChemicalClass ;
rdfs:comment "Chemical class of a ligand" .
### http://www.guidetopharmacology.org/ns/gtpo/hasLigand
gtpo:hasLigand rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Interaction ;
rdfs:range gtpo:Ligand ;
rdfs:comment "ligand participant of an interaction" .
### http://www.guidetopharmacology.org/ns/gtpo/hasRef
gtpo:hasRef rdf:type owl:ObjectProperty ;
rdfs:domain [ rdf:type owl:Class ;
owl:unionOf ( gtpo:Ligand
gtpo:Target
)
] ;
rdfs:comment "Reference to Blank node pair, containing cross reference and taxonomy" .
### http://www.guidetopharmacology.org/ns/gtpo/hasReference
gtpo:hasReference rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Interaction ;
rdfs:comment "Reference to PubMed id of article describing interaction" .
### http://www.guidetopharmacology.org/ns/gtpo/hasSpecies
gtpo:hasSpecies rdf:type owl:ObjectProperty ;
rdfs:domain [ rdf:type owl:Class ;
owl:unionOf ( gtpo:Interaction
gtpo:Ligand
gtpo:Target
)
] ;
rdfs:comment "Cross reference to NCBI taxonomy" .
### http://www.guidetopharmacology.org/ns/gtpo/hasTarget
gtpo:hasTarget rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Interaction ;
rdfs:range gtpo:Target ;
rdfs:comment "target participant of an interaction" .
### http://www.guidetopharmacology.org/ns/gtpo/hasTargetFamily
gtpo:hasTargetFamily rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Target ;
rdfs:range gtpo:TargetFamily ;
rdfs:comment "target family of a target" .
### http://www.guidetopharmacology.org/ns/gtpo/hasTargetFamilyClass
gtpo:hasTargetFamilyClass rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:TargetFamily ;
rdfs:range gtpo:TargetFamilyClass ;
rdfs:comment "Class of target family" .
### http://www.guidetopharmacology.org/ns/gtpo/hasType
gtpo:hasType rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Interaction ;
rdfs:range gtpo:Type ;
rdfs:comment "Action type of an interaction" .
### http://www.guidetopharmacology.org/ns/gtpo/hasUnit
gtpo:hasUnit rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Interaction ;
rdfs:comment "Cross reference to unit description from BAO ontology" .
### http://www.guidetopharmacology.org/ns/gtpo/isomericSMILES
gtpo:isomericSMILES rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Ligand ;
rdfs:range xsd:string .
### http://www.guidetopharmacology.org/ns/gtpo/iupacName
gtpo:iupacName rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Ligand ;
rdfs:range xsd:string .
### http://www.guidetopharmacology.org/ns/gtpo/ligandName
gtpo:ligandName rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Ligand ;
rdfs:range xsd:string .
### http://www.guidetopharmacology.org/ns/gtpo/nomenclature
gtpo:nomenclature rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Target ;
rdfs:range xsd:string .
### http://www.guidetopharmacology.org/ns/gtpo/synonym
gtpo:synonym rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:Ligand ;
rdfs:range xsd:string .
### http://www.guidetopharmacology.org/ns/gtpo/targetFamilyClassName
gtpo:targetFamilyClassName rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:TargetFamilyClass ;
rdfs:range xsd:string .
### http://www.guidetopharmacology.org/ns/gtpo/targetFamilyName
gtpo:targetFamilyName rdf:type owl:ObjectProperty ;
rdfs:domain gtpo:TargetFamily ;
rdfs:range xsd:string .
### http://www.guidetopharmacology.org/ns/gtpo/xref
gtpo:xref rdf:type owl:ObjectProperty ;
rdfs:domain [ rdf:type owl:Class ;
owl:unionOf ( gtpo:Ligand
gtpo:Target
)
] ;
rdfs:comment "Cross reference to external database" .
#################################################################
# Data properties
#################################################################
### http://www.guidetopharmacology.org/ns/gtpo/InChIID
gtpo:InChIID rdf:type owl:DatatypeProperty .
### http://www.guidetopharmacology.org/ns/gtpo/InChIKEY
gtpo:InChIKEY rdf:type owl:DatatypeProperty .
### http://www.guidetopharmacology.org/ns/gtpo/approved
gtpo:approved rdf:type owl:DatatypeProperty .
### http://www.guidetopharmacology.org/ns/gtpo/canonicalSMILES
gtpo:canonicalSMILES rdf:type owl:DatatypeProperty .
### http://www.guidetopharmacology.org/ns/gtpo/chemicalClassName
gtpo:chemicalClassName rdf:type owl:DatatypeProperty .
### http://www.guidetopharmacology.org/ns/gtpo/comment
gtpo:comment rdf:type owl:DatatypeProperty .
### http://www.guidetopharmacology.org/ns/gtpo/hasHighValue
gtpo:hasHighValue rdf:type owl:DatatypeProperty ;
rdfs:domain gtpo:Interaction ;
rdfs:range xsd:double ;
rdfs:label "has high value" ;
rdfs:comment "High value of an interaction affinity, also has low value" ;
rdfs:seeAlso gtpo:hasLowValue .
### http://www.guidetopharmacology.org/ns/gtpo/hasLowValue
gtpo:hasLowValue rdf:type owl:DatatypeProperty ;
rdfs:domain gtpo:Interaction ;
rdfs:range xsd:double ;
rdfs:comment "Low value of an interaction affinity, also has high value" ;
rdfs:label "has low value" ;
rdfs:seeAlso gtpo:hasHighValue .
### http://www.guidetopharmacology.org/ns/gtpo/hasMedianValue
gtpo:hasMedianValue rdf:type owl:DatatypeProperty ;
rdfs:label "has median value" ;
rdfs:domain gtpo:Interaction ;
rdfs:range xsd:double ;
rdfs:comment "Median value of an interaction affinity" .
### http://www.guidetopharmacology.org/ns/gtpo/isomericSMILES
gtpo:isomericSMILES rdf:type owl:DatatypeProperty .
### http://www.guidetopharmacology.org/ns/gtpo/iupacName
gtpo:iupacName rdf:type owl:DatatypeProperty .
### http://www.guidetopharmacology.org/ns/gtpo/ligandName
gtpo:ligandName rdf:type owl:DatatypeProperty .
### http://www.guidetopharmacology.org/ns/gtpo/nomenclature
gtpo:nomenclature rdf:type owl:DatatypeProperty .
### http://www.guidetopharmacology.org/ns/gtpo/synonym
gtpo:synonym rdf:type owl:DatatypeProperty .
### http://www.guidetopharmacology.org/ns/gtpo/targetFamilyClassName
gtpo:targetFamilyClassName rdf:type owl:DatatypeProperty .
### http://www.guidetopharmacology.org/ns/gtpo/targetFamilyName
gtpo:targetFamilyName rdf:type owl:DatatypeProperty .
#################################################################
# Classes
#################################################################
### http://www.guidetopharmacology.org/ns/gtpo/Action
gtpo:Action rdf:type owl:Class ;
rdfs:comment "Class describing different interaction actions, defined by Guide to Pharmacology" .
### http://www.guidetopharmacology.org/ns/gtpo/Activation
gtpo:Activation rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/Activator
gtpo:Activator rdf:type owl:Class ;
rdfs:subClassOf gtpo:Type .
### http://www.guidetopharmacology.org/ns/gtpo/Agonist
gtpo:Agonist rdf:type owl:Class ;
rdfs:subClassOf gtpo:Type .
### http://www.guidetopharmacology.org/ns/gtpo/AgonistAction
gtpo:AgonistAction rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/AllostericModulator
gtpo:AllostericModulator rdf:type owl:Class ;
rdfs:subClassOf gtpo:Type .
### http://www.guidetopharmacology.org/ns/gtpo/AnnotatedAwaitingReview
gtpo:AnnotatedAwaitingReview rdf:type owl:Class ;
rdfs:subClassOf gtpo:AnnotationStatus .
### http://www.guidetopharmacology.org/ns/gtpo/AnnotatedExpertReviewed
gtpo:AnnotatedExpertReviewed rdf:type owl:Class ;
rdfs:subClassOf gtpo:AnnotationStatus .
### http://www.guidetopharmacology.org/ns/gtpo/AnnotationStatus
gtpo:AnnotationStatus rdf:type owl:Class ;
rdfs:comment "Class describing annotation status of targets, defined by Guide to Pharmacology" .
### http://www.guidetopharmacology.org/ns/gtpo/Antagonist
gtpo:Antagonist rdf:type owl:Class ;
rdfs:subClassOf gtpo:Type .
### http://www.guidetopharmacology.org/ns/gtpo/AntagonistAction
gtpo:AntagonistAction rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/Antibody
gtpo:Antibody rdf:type owl:Class ;
rdfs:subClassOf gtpo:Type .
### http://www.guidetopharmacology.org/ns/gtpo/BiasedAgonist
gtpo:BiasedAgonist rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/Binding
gtpo:Binding rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/Biphasic
gtpo:Biphasic rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/ChannelBlocker
gtpo:ChannelBlocker rdf:type owl:Class ;
rdfs:subClassOf gtpo:Type .
### http://www.guidetopharmacology.org/ns/gtpo/ChemicalClass
gtpo:ChemicalClass rdf:type owl:Class ;
rdfs:comment "Class describing families for different chemicals, defined by Guide to Pharmacology" .
### http://www.guidetopharmacology.org/ns/gtpo/Competitive
gtpo:Competitive rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/FeedbackInhibition
gtpo:FeedbackInhibition rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/FullAgonist
gtpo:FullAgonist rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/GatingInhibitor
gtpo:GatingInhibitor rdf:type owl:Class ;
rdfs:subClassOf gtpo:Type .
### http://www.guidetopharmacology.org/ns/gtpo/Inhibition
gtpo:Inhibition rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/Inhibitor
gtpo:Inhibitor rdf:type owl:Class ;
rdfs:subClassOf gtpo:Type .
### http://www.guidetopharmacology.org/ns/gtpo/Interaction
gtpo:Interaction rdf:type owl:Class ;
rdfs:comment "Class describing the interactions between chemicals and proteins stored in the Guide to Pharmacology data" .
### http://www.guidetopharmacology.org/ns/gtpo/InverseAgonist
gtpo:InverseAgonist rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/IrreversibleAgonist
gtpo:IrreversibleAgonist rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/IrreversibleInhibition
gtpo:IrreversibleInhibition rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/Ligand
gtpo:Ligand rdf:type owl:Class ;
rdfs:comment "Class describing the chemicals stored in the Guide to Pharmacology data" .
### http://www.guidetopharmacology.org/ns/gtpo/Mixed
gtpo:Mixed rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/Negative
gtpo:Negative rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/Neutral
gtpo:Neutral rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/NoAction
gtpo:NoAction rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/NonCompetitive
gtpo:NonCompetitive rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/None
gtpo:None rdf:type owl:Class ;
rdfs:subClassOf gtpo:Type .
### http://www.guidetopharmacology.org/ns/gtpo/PartialAgonist
gtpo:PartialAgonist rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/PoreBlocker
gtpo:PoreBlocker rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/Positive
gtpo:Positive rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/Potentiation
gtpo:Potentiation rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/SlowsInactivation
gtpo:SlowsInactivation rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/SubunitSpecific
gtpo:SubunitSpecific rdf:type owl:Class ;
rdfs:subClassOf gtpo:Type .
### http://www.guidetopharmacology.org/ns/gtpo/Target
gtpo:Target rdf:type owl:Class ;
rdfs:comment "Class describing the different proteins stored in the Guide to Pharmacology data" .
### http://www.guidetopharmacology.org/ns/gtpo/TargetFamily
gtpo:TargetFamily rdf:type owl:Class ;
rdfs:comment "Class describing families of proteins stored in the Guide to Pharmacology data" .
### http://www.guidetopharmacology.org/ns/gtpo/TargetFamilyClass
gtpo:TargetFamilyClass rdf:type owl:Class ;
rdfs:comment "Class describing class of protein families stored in the Guide to Pharmacology data" .
### http://www.guidetopharmacology.org/ns/gtpo/Type
gtpo:Type rdf:type owl:Class ;
rdfs:comment "Class describing different interaction action types, defined by Guide to Pharmacology" .
### http://www.guidetopharmacology.org/ns/gtpo/UnderDevelopment
gtpo:UnderDevelopment rdf:type owl:Class ;
rdfs:subClassOf gtpo:AnnotationStatus .
### http://www.guidetopharmacology.org/ns/gtpo/Unknown
gtpo:Unknown rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.guidetopharmacology.org/ns/gtpo/VoltageDependentInbibition
gtpo:VoltageDependentInbibition rdf:type owl:Class ;
rdfs:subClassOf gtpo:Action .
### http://www.w3.org/2001/XMLSchema#string
xsd:string rdf:type owl:Class .
#################################################################
# Annotations
#################################################################
gtpo:InChIID rdfs:comment "InChI identifier for a ligand" .
gtpo:InChIKEY rdfs:comment "InChI key defining a ligand" .
gtpo:approved rdfs:comment "approval status of a ligand" .
gtpo:canonicalSMILES rdfs:comment "canonical SMILES, describing a ligand" .
gtpo:chemicalClassName rdfs:comment "name of a given chemical class" .
gtpo:comment rdfs:comment "Guide to Pharmacology comments on a ligand" .
gtpo:isomericSMILES rdfs:comment "isomeric SMILES, describing a ligand" .
gtpo:iupacName rdfs:comment "name of a ligand, defined by the IUPAC" .
gtpo:ligandName rdfs:comment "the name of a chemical ligand" .
gtpo:nomenclature rdfs:comment "nomenclature, the name of a target" .
gtpo:synonym rdfs:comment "synonym of a ligand" .
gtpo:targetFamilyClassName rdfs:comment "name for target family class" .
gtpo:targetFamilyName rdfs:comment "name for target family" .
### Generated by the OWL API (version 4.2.8.20170104-2310) https://github.com/owlcs/owlapi