diff --git a/Misc/NEWS.d/next/Core and Builtins/2023-10-12-06-32-25.gh-issue-110752.FYfI0h.rst b/Misc/NEWS.d/next/Core and Builtins/2023-10-12-06-32-25.gh-issue-110752.FYfI0h.rst
new file mode 100644
index 000000000000000..fa1a59ec927bb8e
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2023-10-12-06-32-25.gh-issue-110752.FYfI0h.rst	
@@ -0,0 +1 @@
+Reset ``ceval.eval_breaker`` in :func:`interpreter_clear`
diff --git a/Python/pystate.c b/Python/pystate.c
index 2086bd619df9125..92cf741f4ca4ed2 100644
--- a/Python/pystate.c
+++ b/Python/pystate.c
@@ -890,6 +890,10 @@ interpreter_clear(PyInterpreterState *interp, PyThreadState *tstate)
 
     Py_CLEAR(interp->audit_hooks);
 
+    // At this time, all the threads should be cleared so we don't need
+    // atomic operations for eval_breaker
+    interp->ceval.eval_breaker = 0;
+
     for (int i = 0; i < _PY_MONITORING_UNGROUPED_EVENTS; i++) {
         interp->monitors.tools[i] = 0;
     }