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GeneMANIA finds other genes that are related to a set of input genes, using a very large set of functional association data. Association data include protein and genetic interactions, pathways, co-expression, co-localization and protein domain similarity. You can use GeneMANIA to find new members of a pathway or complex, find additional genes you may have missed in your screen or find new genes with a specific function, such as protein kinases. Your question is defined by the set of genes you input.
If members of your gene list make up a protein complex, GeneMANIA will return more potential members of the protein complex. If you enter a gene list, GeneMANIA will return connections between your genes, within the selected datasets. Learn more…
GeneMANIA is also accessible via a Cytoscape app, designed for power users.
GeneMANIA is actively developed at the University of Toronto, in the Donnelly Centre for Cellular and Biomolecular Research, in the labs of Gary Bader and Quaid Morris. GeneMANIA development was originally funded by Genome Canada, through the Ontario Genomics Institute (2007-OGI-TD-05) and is now funded by the Ontario Ministry of Research and Innovation. GeneMANIA is also supported by the National Resource for Network Biology (P41 GM103504).