SUMMARY.md

Table of contents

• Using Systems Biology to Understand Immunosenescence

Background

• Introduction
• 1.1. Aging in Society and in the Individual
• 1.2. Aging and its Molecular Mechanisms
• 1.3.The Remodeling of the Immune System: Immunosenescence
• 1.4. Changes in the Immune System Related to Immunosenescence
• 1.5 Chronic Inflammation During Aging: Inflammaging
• 1.6 The Immune Risk Phenotype (IRP)
• 1.6. Systems Biology

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• Objectives

Methods

• Overall Methodology
• 3.1 Survey of Studies
• 3.2. Reannotation of Probes in Microarrays
• 3.3. Data acquisition and pre-processing
• 3.4. Creation of age-representative samples: AgeCollapsed
• 3.5. Detection of Highly Age-Related Transcripts: AgingGenes
• 3.6. Lifetime Co-Expressed Transcript Analysis: AgingNet
• 3.7. Detection of Change Points in Age-Related Modules

Results

• 4.1. Survey and Data Acquisition
• 4.2. Reannotation of Platforms
• 4.3. AgeCollapsed Pre-Processing and Creation
• 4.4. Assessment of the Agreement of the Relationships of Transcripts with Age between the Sexes
• 4.5. AgingGenes and AgingNet Reviews
• 4.6 Aging Co-Expression Network: AgingNet

Discussion

• Main Regards
• AgingGenes
• Análise de Co-Expressão: AgingNet

Conclusions

• Final Regards

Citations

• References

Appendix

• Supplementary Files