diff --git a/pdb2pqr/__init__.py b/pdb2pqr/__init__.py
index f9c2c1a8..f9494733 100644
--- a/pdb2pqr/__init__.py
+++ b/pdb2pqr/__init__.py
@@ -10,6 +10,7 @@
 
 from ._version import __version__
 from .main import main as pdb2pqr_main
+from .main import run_pdb2pqr
 
 _LOGGER = logging.getLogger(__name__)
 logging.captureWarnings(capture=True)
diff --git a/pdb2pqr/main.py b/pdb2pqr/main.py
index a9a1a93a..a4736371 100644
--- a/pdb2pqr/main.py
+++ b/pdb2pqr/main.py
@@ -7,11 +7,15 @@
 .. codeauthor:: Nathan Baker (et al.)
 """
 
+from __future__ import annotations
+
 import argparse
 import logging
 import sys
 from collections import OrderedDict
+from collections.abc import Sequence
 from io import StringIO
+from os import PathLike
 from pathlib import Path
 
 import propka.input as pk_in
@@ -224,7 +228,7 @@ def build_main_parser():
             "calculation method."
         ),
     )
-    pars = propka.lib.build_parser(pars)
+    pars: argparse.ArgumentParser = propka.lib.build_parser(pars)
 
     # Override version flag set by PROPKA
     pars.add_argument(
@@ -755,7 +759,7 @@ def non_trivial(args, biomolecule, ligand, definition, is_cif):
     }
 
 
-def main_driver(args):
+def main_driver(args: argparse.Namespace):
     """Main driver for running program from the command line.
 
     Validate inputs, launch PDB2PQR, handle output.
@@ -763,7 +767,6 @@ def main_driver(args):
     :param args:  command-line arguments
     :type args:  argparse.Namespace
     """
-    io.setup_logger(args.output_pqr, args.log_level)
     _LOGGER.debug(f"Invoked with arguments: {args}")
     print_splash_screen(args)
     _LOGGER.info("Checking and transforming input arguments.")
@@ -836,10 +839,27 @@ def main():
     """Hook for command-line usage."""
     parser = build_main_parser()
     args = parser.parse_args()
+    io.setup_logger(args.output_pqr, args.log_level)
     if main_driver(args) == 1:
         sys.exit(1)
 
 
+def run_pdb2pqr(args: Sequence[str | PathLike]):
+    """Run PDB2PQR with a list of arguments.
+
+    Logger is not set up so that it can be called multiple times.
+
+    :param args:  list of command-line arguments
+    :type args:  list
+    :return:  results of PDB2PQR run
+    :rtype:  tuple
+    """
+    args_strlist = [str(arg) for arg in args]
+    parser = build_main_parser()
+    args_parsed = parser.parse_args(args_strlist)
+    return main_driver(args_parsed)
+
+
 def dx_to_cube():
     """Convert DX file format to Cube file format.
 
diff --git a/tests/common.py b/tests/common.py
index ebb1f558..8dc02f2a 100644
--- a/tests/common.py
+++ b/tests/common.py
@@ -203,7 +203,7 @@ def compare_pqr(pqr1_path, pqr2_path, compare_resnames=False):
                 _LOGGER.info(result)
 
 
-def run_pdb2pqr(
+def run_pdb2pqr_for_tests(
     args,
     input_pdb,
     tmp_path,
diff --git a/tests/core_test.py b/tests/core_test.py
index a01f1cce..b3c4a8df 100644
--- a/tests/core_test.py
+++ b/tests/core_test.py
@@ -65,7 +65,7 @@ def test_short_pdb(input_pdb, tmp_path):
     """Non-regression tests on short list of PDB-format biomolecules."""
     args = "--log-level=INFO --ff=AMBER --drop-water --apbs-input=apbs.in"
     output_pqr = Path(input_pdb).stem + ".pqr"
-    common.run_pdb2pqr(
+    common.run_pdb2pqr_for_tests(
         args=args,
         input_pdb=input_pdb,
         output_pqr=output_pqr,
@@ -78,7 +78,7 @@ def test_basic_cif(input_pdb, tmp_path):
     """Non-regression tests on short list of CIF-format biomolecules."""
     args = "--log-level=INFO --ff=AMBER --drop-water --apbs-input=apbs.in"
     output_pqr = Path(input_pdb).stem + ".cif"
-    common.run_pdb2pqr(
+    common.run_pdb2pqr_for_tests(
         args=args,
         input_pdb=input_pdb,
         output_pqr=output_pqr,
@@ -92,7 +92,7 @@ def test_long_pdb(input_pdb, tmp_path):
     """Non-regression tests on short list of PDB-format biomolecules."""
     args = "--log-level=INFO --ff=AMBER --drop-water --apbs-input=apbs.in"
     output_pqr = Path(input_pdb).stem + ".pqr"
-    common.run_pdb2pqr(
+    common.run_pdb2pqr_for_tests(
         args=args,
         input_pdb=input_pdb,
         output_pqr=output_pqr,
@@ -106,7 +106,7 @@ def test_broken_backbone(input_pdb, tmp_path):
     """Test graceful failure of optimization with missing backbone atoms."""
     args = "--log-level=INFO --ff=AMBER --drop-water"
     output_pqr = Path(input_pdb).stem + ".pqr"
-    common.run_pdb2pqr(
+    common.run_pdb2pqr_for_tests(
         args=args,
         input_pdb=input_pdb,
         output_pqr=output_pqr,
@@ -122,7 +122,7 @@ def test_protonated_terminals(input_pdb, expected_pqr, tmp_path):
     """Tests for terminal residue protonation."""
     args = "--log-level=INFO --ff=AMBER --ffout AMBER"
     output_pqr = Path(input_pdb).stem + ".pqr"
-    common.run_pdb2pqr(
+    common.run_pdb2pqr_for_tests(
         args=args,
         input_pdb=common.DATA_DIR / input_pdb,
         output_pqr=output_pqr,
@@ -146,7 +146,7 @@ def test_cyclic_peptide(input_pdb, expected_pqr, tmp_path):
     """Tests for cyclic peptide protonation."""
     args = "--log-level=INFO --ff=AMBER --ffout AMBER"
     output_pqr = Path(input_pdb).stem + ".pqr"
-    common.run_pdb2pqr(
+    common.run_pdb2pqr_for_tests(
         args=args,
         input_pdb=common.DATA_DIR / input_pdb,
         output_pqr=output_pqr,
@@ -170,7 +170,7 @@ def test_ph_naming(naming_test, tmp_path):
         f"--drop-water --whitespace --with-ph={naming_test['pH']} "
         f"--titration-state-method=propka"
     )
-    common.run_pdb2pqr(
+    common.run_pdb2pqr_for_tests(
         args=args,
         input_pdb=common.DATA_DIR / input_pdb,
         output_pqr=output_pqr,
diff --git a/tests/ligand_test.py b/tests/ligand_test.py
index 0938f65f..22afffe1 100644
--- a/tests/ligand_test.py
+++ b/tests/ligand_test.py
@@ -188,7 +188,7 @@ def test_ligand_biomolecule(input_pdb, tmp_path):
     args = f"--log-level=INFO --ff=AMBER --drop-water --ligand={ligand}"
     output_pqr = Path(input_pdb).stem + ".pqr"
     _LOGGER.debug(f"Running test in {tmp_path}")
-    common.run_pdb2pqr(
+    common.run_pdb2pqr_for_tests(
         args=args,
         input_pdb=input_pdb,
         output_pqr=output_pqr,
diff --git a/tests/logging_test.py b/tests/logging_test.py
index 09e6437c..4cf54bd1 100644
--- a/tests/logging_test.py
+++ b/tests/logging_test.py
@@ -21,7 +21,7 @@ def test_log_output_in_pqr_location(
     args = "--log-level=INFO --ff=AMBER"
     input_path = common.DATA_DIR / input_file
     output_pqr = output_file
-    common.run_pdb2pqr(
+    common.run_pdb2pqr_for_tests(
         args=args,
         input_pdb=input_path,
         output_pqr=output_pqr,
diff --git a/tests/propka_test.py b/tests/propka_test.py
index 46c2c178..1a1949dc 100644
--- a/tests/propka_test.py
+++ b/tests/propka_test.py
@@ -16,7 +16,7 @@ def test_propka_apo(input_pdb, tmp_path):
         "--titration-state-method=propka"
     )
     output_pqr = Path(input_pdb).stem + ".pqr"
-    common.run_pdb2pqr(
+    common.run_pdb2pqr_for_tests(
         args=args,
         input_pdb=input_pdb,
         output_pqr=output_pqr,
diff --git a/tests/regression_test.py b/tests/regression_test.py
index 214bbf94..310cb1b4 100644
--- a/tests/regression_test.py
+++ b/tests/regression_test.py
@@ -29,7 +29,7 @@
 )
 def test_basic(args, input_pdb, output_pqr, expected_pqr, tmp_path):
     """Basic code to run 1AFS."""
-    common.run_pdb2pqr(
+    common.run_pdb2pqr_for_tests(
         args=args,
         input_pdb=input_pdb,
         output_pqr=output_pqr,
@@ -87,7 +87,7 @@ def test_basic(args, input_pdb, output_pqr, expected_pqr, tmp_path):
 )
 def test_forcefields(args, input_pdb, output_pqr, expected_pqr, tmp_path):
     """Basic code to run 1AFS with --whitespace for different forcefields."""
-    common.run_pdb2pqr(
+    common.run_pdb2pqr_for_tests(
         args=args,
         input_pdb=input_pdb,
         output_pqr=output_pqr,
@@ -153,7 +153,7 @@ def test_forcefields(args, input_pdb, output_pqr, expected_pqr, tmp_path):
 )
 def test_other_options(args, input_pdb, output_pqr, expected_pqr, tmp_path):
     """Basic code to run 1AFS with --whitespace."""
-    common.run_pdb2pqr(
+    common.run_pdb2pqr_for_tests(
         args=args,
         input_pdb=input_pdb,
         output_pqr=output_pqr,